CN112703206A - 靶向肿瘤的重组双功能融合蛋白及其应用 - Google Patents

靶向肿瘤的重组双功能融合蛋白及其应用 Download PDF

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CN112703206A
CN112703206A CN202080002411.8A CN202080002411A CN112703206A CN 112703206 A CN112703206 A CN 112703206A CN 202080002411 A CN202080002411 A CN 202080002411A CN 112703206 A CN112703206 A CN 112703206A
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tumor
antibody
tgf
fusion protein
recombinant
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CN112703206B (zh
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余科
任志强
刘亮
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Bailisikang Biomedical Hangzhou Co ltd
Fudan University
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Abstract

一种靶向肿瘤的重组双功能融合蛋白及其应用，具体提供了一种重组双功能融合蛋白，其包含特异性结合靶分子CD73或TF蛋白的第一结合结构域和特异性结合靶分子TGFβ蛋白的第二结合结构域；以及所述抗体融合蛋白的制备方法及其应用。CD73/TF‑TGFβR融合蛋白通过高特异性地阻抑肿瘤微环境中的CD73‑TGFβ或TF‑TGFβ表达水平，改善肿瘤免疫细胞环境，增强肿瘤治疗的效果。该融合蛋白具有很高的靶向亲和力及显著的抗肿瘤活性。

Description

PCT国内申请，说明书已公开。

Claims (24)

  1. PCT国内申请，权利要求书已公开。
CN202080002411.8A 2019-09-05 2020-09-04 靶向肿瘤的重组双功能融合蛋白及其应用 Active CN112703206B (zh)

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PCT/CN2020/113357 WO2021043229A1 (zh) 2019-09-05 2020-09-04 靶向肿瘤的重组双功能融合蛋白及其应用

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CN113450877A (zh) * 2021-06-28 2021-09-28 深圳裕泰抗原科技有限公司 一种基于多重免疫组化技术的生物标志物分析方法及其应用

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CN113773401B (zh) * 2021-09-15 2023-06-20 宜明昂科生物医药技术（上海）股份有限公司 靶向cd47和pd-l1的重组融合蛋白及其制备和用途
WO2023201267A1 (en) 2022-04-13 2023-10-19 Gilead Sciences, Inc. Combination therapy for treating trop-2 expressing cancers
KR20240000394A (ko) * 2022-06-22 2024-01-02 (주)지아이이노베이션 항-cd73 항체 및 il-2를 포함하는 융합단백질 및 이의 용도

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CN113450877A (zh) * 2021-06-28 2021-09-28 深圳裕泰抗原科技有限公司 一种基于多重免疫组化技术的生物标志物分析方法及其应用
CN113450877B (zh) * 2021-06-28 2022-04-08 深圳裕泰抗原科技有限公司 一种基于多重免疫组化技术的生物标志物分析方法及其应用

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