CN112691172A - 预防非洲猪瘟的一种新型添加剂发酵中药 - Google Patents

预防非洲猪瘟的一种新型添加剂发酵中药 Download PDF

Info

Publication number
CN112691172A
CN112691172A CN201911009984.9A CN201911009984A CN112691172A CN 112691172 A CN112691172 A CN 112691172A CN 201911009984 A CN201911009984 A CN 201911009984A CN 112691172 A CN112691172 A CN 112691172A
Authority
CN
China
Prior art keywords
traditional chinese
chinese medicine
fermented
fermented traditional
swine fever
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201911009984.9A
Other languages
English (en)
Inventor
李大伟
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201911009984.9A priority Critical patent/CN112691172A/zh
Publication of CN112691172A publication Critical patent/CN112691172A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
    • A23K10/12—Animal feeding-stuffs obtained by microbiological or biochemical processes by fermentation of natural products, e.g. of vegetable material, animal waste material or biomass
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
    • A61K36/12—Filicopsida or Pteridopsida
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/19—Acanthaceae (Acanthus family)
    • A61K36/195—Strobilanthes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282—Artemisia, e.g. wormwood or sagebrush
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
    • A61K36/296—Epimedium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A61K36/315—Isatis, e.g. Dyer's woad
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/344—Codonopsis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/51—Gentianaceae (Gentian family)
    • A61K36/515—Gentiana
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718—Coptis (goldthread)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734—Crataegus (hawthorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8998—Hordeum (barley)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00—Lactic or propionic acid bacteria
    • A23V2400/11—Lactobacillus
    • A23V2400/113—Acidophilus
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00—Lactic or propionic acid bacteria
    • A23V2400/11—Lactobacillus
    • A23V2400/169—Plantarum
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00—Lactic or propionic acid bacteria
    • A23V2400/51—Bifidobacterium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
    • Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
    • Y02P60/87—Re-use of by-products of food processing for fodder production

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • Polymers & Plastics (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Animal Husbandry (AREA)
  • Food Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physiology (AREA)
  • Organic Chemistry (AREA)
  • Birds (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Sustainable Development (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

本发明提供了预防非洲猪瘟的一种新型添加剂发酵中药，该添加剂发酵中药由中药化裁辅以八种活菌配置而成，其中中药的具体成分如下：黄芪120g，当归30g，甘草15g，川芎25g，党参60g，白术30g，板蓝根60g。本发明通过在黄芪、当归、甘草等混合发酵的中药材中添加蟾酥抗菌肽芽孢杆菌、双歧杆菌等八种活菌，使得该发酵中药产生了补气、活血化瘀、止痛、改善微循环、清泄肝胆实火、排毒解毒、补中益气、补肾填精、提升特异性和非特异性免疫力、调理胃肠、补充营养、消食健胃、提高饲料转化率、改善环境、降低动物呼吸道发病率的功效，同时八种活菌增效中药效用达30倍左右，使得中药的药效得到充分的发挥，确保了该发酵中药对非洲猪瘟的防治效果。

Description

预防非洲猪瘟的一种新型添加剂发酵中药
技术领域
本发明属于预防非洲猪瘟的中药技术领域，尤其是涉及预防非洲猪瘟的一种新型添加剂发酵中药。
背景技术
非洲猪瘟是一种急性、发热传染性很高的滤过性病毒所引起的猪病，其特征是发病过程短，但死亡率高达100％，病猪临床表现为发热，皮肤发绀，***，肾，胃肠粘膜明显出血。
在生猪养殖的过程中，养殖户会不可避免的遇到非洲猪瘟的问题，为了能够避免非洲猪瘟对生猪的影响，确保养殖户的收益，本发明提出了预防非洲猪瘟的一种新型添加剂发酵中药，克服了传统的发酵中药药效低、中药药效得不到充分发挥、对非洲猪瘟的防治效果差的弊端。
发明内容
有鉴于此，本发明旨在提出预防非洲猪瘟的一种新型添加剂发酵中药，能够有效增强机体免疫力，提高机体的消化吸收效率，预防非洲猪瘟的发生。
为达到上述目的，本发明的技术方案是这样实现的：
预防非洲猪瘟的一种新型添加剂发酵中药，该添加剂发酵中药由中药化裁辅以八种活菌配置而成，其中中药的具体成分如下：黄芪120g，当归30g，甘草15g，川芎25g，党参60g，白术30g，板蓝根60g，淫羊藿30g，龙胆45g，黄连35g，何首乌25g，白头翁45g，陈皮25g，麦芽120g，神曲60克g，山楂60g，艾叶30g，绵马贯众20。
进一步的，所述的八种活菌分别为枯草芽孢杆菌、蟾酥抗菌肽芽孢杆菌、植物乳酸菌、嗜酸乳杆菌、双歧杆菌、丁酸梭菌、地衣芽孢杆菌、酵母菌，活菌蟾酥抗菌肽芽孢杆菌的添加，能有效抑制癌细胞及肿瘤的生长，对多重耐药菌和肿瘤细胞有较强的灭活作用，而不会破坏动物机体的正常细胞，是一类具有巨大发展潜力的新型抗菌肽，也是目前抗病原微生物开发的一个热点，双歧杆菌的添加也解决了本品的抗菌抗病毒的效果，而枯草芽孢杆菌、地衣芽孢杆菌、嗜酸乳杆菌、丁酸梭菌等的参与，可促进包括B细胞、T细胞、M细胞、吞噬细胞、体液免疫、细胞免疫、产溶菌酶细胞在内的免疫细胞的活性，产生多种消化酶，促进对蛋白质、脂类、碳水化合物、维生素、无机盐和黏液代谢等营养的消化、吸收和代谢，并能使胃肠菌群产生迁移传动复合物，刺激肠蠕动，而且还能代谢产酸，酸化肠道环境，活化酶***和抑制偏碱性有害微生物的生长。动物的微生态***就是通过上述多种作用，最终产生抑制有害菌群，增强免疫功能，防治疾病，提高饲料营养素的消化吸收和转化效率，促进动物产品的形成和品质改善。
进一步的，所述的八种活菌的含量均大于等于2.0X107Cfu/g，通过上述八种活菌的共同作用，使得该发酵中药产生了补气、活血化瘀、止痛、改善微循环、清泄肝胆实火、排毒解毒、补中益气、补肾填精、提升特异性和非特异性免疫力、调理胃肠、补充营养、消食健胃、提高饲料转化率、改善环境、降低动物呼吸道发病率的功效，同时八种活菌增效中药效用达30倍左右，使得中药的药效得到充分的发挥，确保了该发酵中药对非洲猪瘟的防治效果。
所述的添加剂发酵中药的制备方法，包括如下步骤：
(1)取上述重量份的黄芪、当归、甘草、川芎、党参等中药材，进行混合粉碎，并进行熬制浓缩处理，以制得浓缩液备用；
(2)将上述八种活菌以及步骤(1)所制得的浓缩液混到一起，进行发酵；
(3)发酵一段时间后，只需将发酵好的物料进行密封装袋，即可投入使用。
进一步的，所述的步骤(2)中的发酵温度为42℃，所述步骤(2)中的发酵时间为20ds。
进一步的，该发酵中药的实用方法如下：母猪在非洲猪瘟瘟期间按4％添加一月即可抵抗该病的影响，由于母猪体内毒素承载量大，所以周期30天左右，只要用到时用够量即可，保育猪、中大猪可按4％～6％添加三周以上也是可以的。
相对于现有技术，本发明所述的添加剂发酵中药具有以下优势：
本发明通过在黄芪、当归、甘草等混合发酵的中药材中添加蟾酥抗菌肽芽孢杆菌、双歧杆菌等八种活菌，使得该发酵中药产生了补气、活血化瘀、止痛、改善微循环、清泄肝胆实火、排毒解毒、补中益气、补肾填精、提升特异性和非特异性免疫力、调理胃肠、补充营养、消食健胃、提高饲料转化率、改善环境、降低动物呼吸道发病率的功效，同时八种活菌增效中药效用达30倍左右，使得中药的药效得到充分的发挥，确保了该发酵中药对非洲猪瘟的防治效果。
具体实施方式
发酵中药是将天然药物(中药)提取液以优选的肠道益生菌菌群中一种或几种、一株或几株益生菌作为菌种，利用微生态学、仿生学的方法，通过生物嫁接的方式，在体外模拟机体的肠道环境和中药成分在机体内的消化分解过程，对提取的中药有效成分进行生物学转化，将中药的大分子物质，经过微生物转化成为能够被机体肠道直接吸收的小分子成分，使中药成为快速吸收、定量疗效的新型药物。
基于上述作用机理，本发明提供了预防非洲猪瘟的一种新型添加剂发酵中药，该添加剂发酵中药由中药化裁辅以八种活菌配置而成，其中中药的具体成分如下：黄芪120g，当归30g，甘草15g，川芎25g，党参60g，白术30g，板蓝根60g，淫羊藿30g，龙胆45g，黄连35g，何首乌25g，白头翁45g，陈皮25g，麦芽120g，神曲60克g，山楂60g，艾叶30g，绵马贯众20。
优选的，所述的八种活菌分别为枯草芽孢杆菌、蟾酥抗菌肽芽孢杆菌、植物乳酸菌、嗜酸乳杆菌、双歧杆菌、丁酸梭菌、地衣芽孢杆菌、酵母菌，活菌蟾酥抗菌肽芽孢杆菌的添加，能有效抑制癌细胞及肿瘤的生长，对多重耐药菌和肿瘤细胞有较强的灭活作用，而不会破坏动物机体的正常细胞，是一类具有巨大发展潜力的新型抗菌肽，也是目前抗病原微生物开发的一个热点，双歧杆菌的添加也解决了本品的抗菌抗病毒的效果，而枯草芽孢杆菌、地衣芽孢杆菌、嗜酸乳杆菌、丁酸梭菌等的参与，可促进包括B细胞、T细胞、M细胞、吞噬细胞、体液免疫、细胞免疫、产溶菌酶细胞在内的免疫细胞的活性，产生多种消化酶，促进对蛋白质、脂类、碳水化合物、维生素、无机盐和黏液代谢等营养的消化、吸收和代谢，并能使胃肠菌群产生迁移传动复合物，刺激肠蠕动，而且还能代谢产酸，酸化肠道环境，活化酶***和抑制偏碱性有害微生物的生长。动物的微生态***就是通过上述多种作用，最终产生抑制有害菌群，增强免疫功能，防治疾病，提高饲料营养素的消化吸收和转化效率，促进动物产品的形成和品质改善。
优选的，所述的八种活菌的含量均大于等于2.0X107Cfu/g，通过上述八种活菌的共同作用，使得该发酵中药产生了补气、活血化瘀、止痛、改善微循环、清泄肝胆实火、排毒解毒、补中益气、补肾填精、提升特异性和非特异性免疫力、调理胃肠、补充营养、消食健胃、提高饲料转化率、改善环境、降低动物呼吸道发病率的功效，同时八种活菌增效中药效用达30倍左右，使得中药的药效得到充分的发挥，确保了该发酵中药对非洲猪瘟的防治效果。
所述的添加剂发酵中药的制备方法，包括如下步骤：
(1)取上述重量份的黄芪、当归、甘草、川芎、党参等中药材，进行混合粉碎，并进行熬制浓缩处理，以制得浓缩液备用；
(2)将上述八种活菌以及步骤(1)所制得的浓缩液混到一起，进行发酵；
(3)发酵一段时间后，只需将发酵好的物料进行密封装袋，即可投入使用。
优选的，所述的步骤(2)中的发酵温度为42℃，所述步骤(2)中的发酵时间为20ds。
优选的，该发酵中药的实用方法如下：母猪在非洲猪瘟瘟期间按4％添加一月即可抵抗该病的影响，由于母猪体内毒素承载量大，所以周期30天左右，只要用到时用够量即可，保育猪、中大猪可按4％～6％添加三周以上也是可以的。
以上所述仅为本发明的较佳实施例而已，并不用以限制本发明，凡在本发明的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本发明的保护范围之内。

Claims (6)

1.预防非洲猪瘟的一种新型添加剂发酵中药，其特征在于：该添加剂发酵中药由中药化裁辅以八种活菌配置而成，其中中药的具体成分如下：黄芪120g，当归30g，甘草15g，川芎25g，党参60g，白术30g，板蓝根60g，淫羊藿30g，龙胆45g，黄连35g，何首乌25g，白头翁45g，陈皮25g，麦芽120g，神曲60克g，山楂60g，艾叶30g，绵马贯众20g。
2.根据权利要求1所述的添加剂发酵中药，其特征在于：所述的八种活菌分别为枯草芽孢杆菌、蟾酥抗菌肽芽孢杆菌、植物乳酸菌、嗜酸乳杆菌、双歧杆菌、丁酸梭菌、地衣芽孢杆菌、酵母菌。
3.根据权利要求1-2所述的添加剂发酵中药，其特征在于：所述的八种活菌的含量均大于等于2.0X107Cfu/g。
4.权利要求1-3中任一项所述的添加剂发酵中药的制备方法，其特征在于：包括如下步骤：
(1)取上述重量份的黄芪、当归、甘草、川芎、党参等中药材，进行混合粉碎，并进行熬制浓缩处理，以制得浓缩液备用；
(2)将上述八种活菌以及步骤(1)所制得的浓缩液混到一起，进行发酵；
(3)发酵一段时间后，只需将发酵好的物料进行密封装袋，即可投入使用。
5.根据权利要求4所述的添加剂发酵中药的制备方法，其特征在于：所述的步骤(2)中的发酵温度为42℃，所述步骤(2)中的发酵时间为20ds。
6.根据权利要求1-5所述的添加剂发酵中药，其特征在于：该发酵中药的使用方法如下：母猪在非洲猪瘟瘟期间按4％添加一月即可抵抗该病的影响，由于母猪体内毒素承载量大，所以周期30天左右，只要用到时用够量即可，保育猪、中大猪可按4％～6％添加三周以上也是可以的。
CN201911009984.9A 2019-10-23 2019-10-23 预防非洲猪瘟的一种新型添加剂发酵中药 Pending CN112691172A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201911009984.9A CN112691172A (zh) 2019-10-23 2019-10-23 预防非洲猪瘟的一种新型添加剂发酵中药

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201911009984.9A CN112691172A (zh) 2019-10-23 2019-10-23 预防非洲猪瘟的一种新型添加剂发酵中药

Publications (1)

Publication Number Publication Date
CN112691172A true CN112691172A (zh) 2021-04-23

Family

ID=75504864

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201911009984.9A Pending CN112691172A (zh) 2019-10-23 2019-10-23 预防非洲猪瘟的一种新型添加剂发酵中药

Country Status (1)

Country Link
CN (1) CN112691172A (zh)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113854401A (zh) * 2021-10-13 2021-12-31 山东大益生物科技集团有限公司 一种发酵中药饲料添加剂及其制备方法
CN114404505A (zh) * 2022-02-25 2022-04-29 广东温氏大华农生物科技有限公司 一种以南药为主的防控非洲猪瘟中药制剂及制备方法
CN114766590A (zh) * 2022-05-14 2022-07-22 宿州市美联阳光饲料有限责任公司 一种中草药型抗病毒饲料
WO2023060671A1 (zh) * 2021-10-11 2023-04-20 海南今珠农业发展有限公司 一种中药多糖饲料添加剂及其应用

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023060671A1 (zh) * 2021-10-11 2023-04-20 海南今珠农业发展有限公司 一种中药多糖饲料添加剂及其应用
CN113854401A (zh) * 2021-10-13 2021-12-31 山东大益生物科技集团有限公司 一种发酵中药饲料添加剂及其制备方法
CN114404505A (zh) * 2022-02-25 2022-04-29 广东温氏大华农生物科技有限公司 一种以南药为主的防控非洲猪瘟中药制剂及制备方法
CN114404505B (zh) * 2022-02-25 2023-01-17 广东温氏大华农生物科技有限公司 一种以南药为主的防控非洲猪瘟中药制剂及制备方法
CN114766590A (zh) * 2022-05-14 2022-07-22 宿州市美联阳光饲料有限责任公司 一种中草药型抗病毒饲料

Similar Documents

Publication Publication Date Title
CN106798862B (zh) 一种用于提高雏鸡免疫力的中药微生态制剂、制备方法及其用法
CN112691172A (zh) 预防非洲猪瘟的一种新型添加剂发酵中药
CN102366023A (zh) 一种含中药活性益生菌的奶牛饲料添加剂的制造方法
CN112494577B (zh) 一种用于治疗仔猪腹泻的中药微生态制剂及其制备方法
CN106420847B (zh) 辅助保护胃黏膜和/或缓解胃胀的组合物及其微生态制剂
CN102366024A (zh) 一种含中药活性益生菌的猪饲料添加剂的制造方法
CN103947906B (zh) 一种猪用微生态制剂及其制备方法
CN102836422A (zh) 防病促长灵
WO2002012446A1 (fr) Culture et fermentation de bacteries intestinales benefiques pour la transformation et la modification de medicaments naturels
CN109350655B (zh) 一种提高猪生长和繁殖性能的发酵中药及其制备方法
CN102920946A (zh) 一种防治猪传染病的中草药活性发酵液的制备方法
CN102367415A (zh) 猪饲料用中药益生菌液体培养基、培养方法及饲料添加剂
CN110946907A (zh) 雏禽用的中药组合物、液态发酵的中药制剂及其制备方法
CN108552429A (zh) 一种用于减少仔猪断奶生长障碍的饲料添加剂
CN102367416B (zh) 牛饲料用中药益生菌固体培养基、培养方法及饲料添加剂
CN104082528B (zh) 一种饲料添加剂及其制备方法
CN101244184A (zh) 一种消化道调节剂及其制备方法和用途
CN103550401A (zh) 一种复合微生态制剂泡腾片的制备方法
CN103495136A (zh) 一种治疗畜禽胃肠道寄生虫病的发酵中草药及其制备方法
CN108782963A (zh) 一种可抗菌提高免疫力的微生态制剂及其制备方法
CN102367420B (zh) 牛饲料用中药益生菌液体培养基、培养方法及饲料添加剂
CN112471350A (zh) 改善蛋鸡生产性能和降低破蛋率的饲料添加剂及制备方法
CN110193030A (zh) 一种犬用微生态制剂及其制备方法
CN108113001B (zh) 一种缓解胃溃疡的益生菌冻干粉
CN102367419A (zh) 禽饲料用中药益生菌液体培养基、培养方法及饲料添加剂

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20210423

RJ01 Rejection of invention patent application after publication