CN112691150A - 一种组合物及其制备方法和应用 - Google Patents
一种组合物及其制备方法和应用 Download PDFInfo
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Abstract
本发明属于医药或食品领域,具体涉及一种组合物,包含0.2~280重量份的枳椇子,0.2~300重量份的番茄;0.1~150重量份藤茶;还涉及该组合物的制备方法及应用。本发明组合物具有抗氧化的功能,并且,本发明组合物对酒精性肝损伤有改善治疗作用,对饮酒引起的不适症状有良好改善效果。
Description
技术领域
本发明属于医药或食品领域,具体涉及一种组合物,还涉及该组合物的制备方法及其在医药或食品中的应用。
背景技术
自由基(Freeradicals)也称为“游离基”,是含有不成对电子的原子团。由于原子形成分子时,化学键中电子必须成对出现,因此自由基夺取其他物质的单个电子,使自身形成稳定的物质,这种现象被称为“氧化”。
自由基具有强氧化性,如体内自由基数量过多会引起脂质过氧化,对生物膜和其他组织造成损伤,破坏细胞结构,使组织细胞失去正常功能,甚至破坏DNA,进而引发多种慢性疾病及加速衰老。正常情况下,人体内存在一定的抗氧化剂,它们能清除过多的自由基,使体内自由基的生成和清除处于动态平衡。如果自由基产生过多和清除自由基能力下降,体内就会有多余的自由基(特别是氧自由基Oxygen-free radical),会损伤细胞成分,但还没有出现疾病的症状,如果不加以调整,继续发展下去就会导致疾病和衰老的发生,这时需要从体外补充抗氧化剂,帮助达到体内自由基的平衡,从而预防疾病的发生。
研究发现,25岁左右时,人体内的抗氧化剂最丰富,以后逐渐减少,过了40岁,减少速度加快,如不及时从体外补充抗氧化剂,人体就容易产生疾病,甚至加快衰老。此外,当人体处于疾病状态,或存在紧张、忧愁、激烈运动、吸烟、过度饮酒等因素,或受到紫外线照射、放射线照射、环境污染等因素的作用时,也会引起自由基产生过量,若此时体内的抗氧化剂不足,无法清除过多的自由基,就会导致人体健康受损。大量研究表明,炎症、肿瘤、衰老、血液病,以及心、肝、肺、皮肤疾病的发生机制与体内过多的自由基、自由基浓度及抗氧化作用的失衡有关。
近年,随着生活水平的提高,人们饮食习惯、生活习惯的改变,慢性病的发生率越来越高。在影响人类的健康长寿的因素中,85%来自自由基的侵害,研究证实:有超过100种疾病与自由基产生过量或人体自身清除自由基能力下降有关,酒精性肝损伤是其中之一。
酒精(乙醇)性肝损伤是由于长期大量饮酒导致的肝脏损伤疾病。初期通常表现为脂肪肝,进而可发展成酒精性肝炎、肝纤维化和肝硬化。严重酗酒时可诱发广泛肝细胞坏死,甚至肝功能衰竭。
很多临床研究表明:乙醇导致的肝脂肪变性与自由基增多有关。乙醇代谢使肝细胞氧化还原反应增高,此反应中自由基产生亦增多,抑制了脂肪酸氧化,致使肝细胞脂肪蓄积。乙醛可促进乙醇诱导自由基生成增加,同时,乙醛可增加肝脏脂质过氧化物含量,降低肝脏谷胱甘肽水平。饮酒过度可激活产生氧自由基和乙醛物质的***,对肝脏造成损伤。
酒中的乙醇进入体内后通过胃肠道吸收,仅有2%-10%由呼吸道、尿液和汗腺以原形排出,其余90%在肝脏内氧化代谢,很少在肝外代谢;经肝脏代谢的乙醇约80%通过乙醇脱氢酶转化为乙醛,约20%通过微粒体乙醇氧化酶转化为乙醛,乙醛再经过乙醛脱氢酶(ALDH)转化为乙酸,乙酸以乙酰CoA的形式进入三羧酸循环,氧化成二氧化碳和水。
乙醛是一种高活性物质,与酒精性肝损伤的发展密切相关。肝细胞线粒体内的乙醛可被ALDH氧化为乙酸,当ALDH活性降低时,未被氧化的乙醛进入血内,通过黄嘌呤氧化酶转变为超氧化物,导致脂质过氧化,破坏细胞膜脂质,促进肝损伤。另外,乙醛可作用于线粒体、微管及质膜等,引起肝细胞退变。同时有研究发现ALDH活性的减弱与肝损伤的程度是平行发展的,乙醛可使肝细胞内线粒体受损,从而使肝细胞对脂肪酸分解功能低下,此时机体可动员皮下脂肪组织的脂肪酸向肝内转移,久而久之形成脂肪肝。
乙醛还可与各种蛋白质相结合形成一种络合物,即乙醛复合体,这些络合物作为一个新的抗原刺激物,导致肝细胞再度受损。该络合物是乙醇诱导氧化应激反应的结果。乙醇滥用可激活产生氧自由基和乙醛物质的***,在这个过程中产生的乙醛和脂质过氧化物能与蛋白质结合形成稳定的络合物,络合物的形成导致蛋白质功能的紊乱、刺激纤维生成及诱导免疫应答。在乙醇滥用患者肝损伤早期,组织病理学发现肝小叶中心的蛋白质络合物是酒精性肝疾病发病机制的主要因素。另外,乙醛的氧化代谢还可促使活性氧的产生,氧自由基增多,进而造成肝细胞损伤及坏死。
有害饮酒已被世界卫生组织(WHO)列入全球过早死亡和致残的第五大主要危险因素,酒精性肝损伤疾病也是我国常见的肝脏疾病之一,严重危害人民健康。
对于“自由基”引起的“氧化”,以及乙醇代谢引发自由基、乙醛增多导致的肝损伤疾病,除了医疗药物干预、改变习惯外,另一个重要的方法是体外补充抗氧化剂,对抗氧化剂的研究是技科研技术研究热点之一。
抗氧化剂的种类很多,如维生素E、维生素C、辅酶Q10、多酚、番茄红素、虾青素、类胡萝卜素等。目前的很多研究报道多为单一物质的研究报道,相互间有协同作用的研究不多见。
枳椇子为鼠李科(Rhamnaceae)枳椇属枳椇(HoveniaacerbaLindl.)的果实或种子,俗称拐枣、金钩子、鸡爪梨、树蜜、万寿果等,是我国***首批公布的新资源食品,我国绝大多数省区均有分布。枳椇子在我国历史久远,《诗经》、《礼记》、《庄子》中均记载。不仅食用亦可入药,中医认为枳椇子具有清热利尿,解酒毒之功效,主治醉酒、烦热、口渴、呕吐、二便不利等症。枳椇子药用始载于《唐本草》,李时珍称它为金果树,并收载入《本草纲目》等多种中医药典籍。
研究发现,枳椇子中含有丰富的碳水化合物、粗蛋白、粗脂肪和粗纤维,必需氨基酸占氨基酸总量的35%,含有K、Ca、Mg、Na、Fe、Mn、Cu、Zn等多种矿物质;脂肪中亚麻酸占约40%;黄酮类占约2.8%。新鲜的枳椇子也可榨汁、可做果酱、可干燥、可经提取做成提取物。枳椇提子取物的标志性成分为黄酮类化合物或二氢杨梅素,含量有多种规格;也有以多糖为标志成分的。现代医学认为,枳椇子具有利尿、解酒护肝、抗肿瘤等作用,提取物效果更优。
番茄(LycopersiconesculentumMill),俗称西红柿,是管状花目、茄科、番茄属草本植物番茄成熟的果实,是生活中常见的果菜之一。番茄含有丰富的维生素、矿物质、糖类、有机酸和果胶等,特别是类胡萝卜素含量高。番茄营养丰富,可以生食、煮食、加工成番茄酱、番茄汁或干燥磨粉或做成提取物食用。
番茄红素是番茄中类胡萝卜素的重要成分之一,番茄鲜果含水80-95%,番茄红素含量较低,据报道不同品种和成熟度差异较大,一般约0.3mg/100g至4.2mg/100g不等。通常黄色番茄番茄红素含量最低,粉色次之,红色较高;樱桃番茄高于普通番茄;番茄汁/酱含量可达9.3-29mg/100g,番茄皮中含量最高可达80-90mg/100g,通过有机溶剂提取或超临界二氧化碳萃取或再经纯后制取不同番茄红素含量的番茄提取物。
番茄红素在体内主要储藏于肝脏,很多研究表明番茄红素具有多种生理功能。李京,惠伯棣等在《番茄红素一被关注的功能因子》(食品科学,2005年08期)一文中报道:番茄红素具有抗氧化,抗癌、预防种瘤,免疫调节,抗疲劳等功能。番茄红素不仅可用作食品天然色素,而且也已越来越多地应用于功能食品、药品和化妆品中。
藤茶又叫莓茶、龙须茶等,学名为显齿蛇葡萄叶,是葡萄科蛇葡萄属显齿蛇葡萄(Ampelopsisgrossedentata)的叶子,国家卫生卫计委2013年第16号公告公布的新食品原料。藤茶嫩叶可直接加水榨汁,可干燥后冲泡,也可用水或乙醇或其他溶剂提取,或再经纯化做成不同规格含量的提取物。藤茶嫩叶经过杀青、揉捻、烘干而成的类似茶叶的产品称为藤茶。藤茶具有一定的药用价值,《中华本草》记载:藤茶,性凉;味苦,微涩;有清热利湿;平肝降压;活血通络等功效。刘慧颖等(《显齿蛇葡萄的化学成分及药理作用研究进展》,安徽农业科学,2016,44(27))报道:藤茶具有抗氧化、抑菌抗病毒、抗炎镇痛、抗癌、降血脂、降血糖,保肝、增强免疫等多方面的作用。
现代研究发现,藤茶中含有黄酮类化合物、酚类、氨基酸及微量元素、多糖、甾体及萜类化合物,挥发油等成分,黄酮类化合物的含量较高,约为45%,二氢杨梅素含量为2.5-40%。二氢杨梅素通常作为藤茶提取物的标志成分,二氢杨梅素又叫蛇葡萄素、白蔹素,化学名为(2R,3R)-3,5,7-三羟基-2-(3,4,5-三羟基苯基)苯并二氢吡喃-4-酮,分子式为C15H12O8,具有抗氧化、抗肿瘤、抗炎、解酒保肝、抗病原微生物及调血脂、降高血压、抑制血栓形成、降血糖等多方面的药理作用。
发明内容
本发明提供了一种组合物,本发明组合物具有抗氧化的功能,组合物原料间有协同作用,能增强整体抗氧化效果。并且,本发明组合物对酒精性肝损伤有改善/治疗作用,对饮酒引起的不适症状有良好改善效果。在此基础上,本发明还提供了一种药物和一种保健食品或健康食品。
本发明第一方面涉及一种组合物,包含:
枳椇子0.2~280重量份(例如0.2重量份、0.3重量份、0.6重量份、1重量份、2重量份、3重量份、8重量份、10重量份、15重量份、20重量份、30重量份、50重量份、60重量份、80重量份、100重量份、130重量份、140重量份、150重量份、155重量份、160重量份、166重量份、170重量份、175重量份、180重量份、186重量份、190重量份、200重量份、220重量份、240重量份、250重量、270重量、280重量份)
番茄0.2~300重量份(例如0.2重量份、0.4重量份、0.6重量份、0.8重量份、1重量份、3重量份、6重量份、8重量份、10重量份、13重量份、15重量份、20重量份、30重量份、50重量份、60重量份、80重量份、100重量份、120重量份、150重量份、155重量份、160重量份、163重量份、168重量份、170重量份、180重量份、186重量份、190重量份、200重量份、220重量份、240重量份、260重量份、280重量份、300重量份)
藤茶0.1~150重量份(例如0.1重量份、0.2重量份、0.5重量份、0.8重量份、1重量份、2重量份、3重量份、5重量份、6重量份、8重量份、10重量份、13重量份、18重量份、20重量份、30重量份、40重量份、60重量份、70重量份、75重量份、80重量份、85重量份、88重量份、90重量份、93重量份、95重量份、97重量份、98重量份、99重量份、100重量份、120重量份、140重量份、150重量份)。
本发明第一方面的一个实施方式中,所述组合物包含:
枳椇子0.3~250重量份;
番茄0.25~250重量份;
藤茶0.15~120重量份。
本发明第一方面的一个实施方式中,所述枳椇子以枳椇子鲜果、枳椇子果汁(原汁和/或浓缩汁)、枳椇子果酱、枳椇子果汁粉、枳椇子粉、枳椇子提取物中的至少一种形式提供,优选的所述枳椇子包含枳椇子果汁、枳椇子粉、枳椇子提取物中的至少一种;其中枳椇子提取物为用水或乙醇或其他溶剂或组合溶剂提取或再经纯化。
本发明第一方面的一个实施方式中,所述茄包含番茄鲜果、番茄果汁(原汁和/或浓缩汁)、番茄果酱、番茄果汁粉、番茄粉、番茄提取物中的至少一种;优选的所述番茄包含番茄果汁、番茄粉、番茄提取物中的至少一种;其中番茄提取物是指以番茄红素为标志成分的番茄提取物,以油树脂、粉末/晶体/颗粒的形式提供;优选地,提取物中番茄红素的含量为1%-99.9%,更优选为1%、2%、5%、8%、10%、20%、40%、50%、70%、90%、95%、98%、99%。
本发明第一方面的一个实施方式中,所述藤茶包含鲜藤茶以及由其嫩叶加工而成的藤茶汁(原汁和/或浓缩汁)、藤茶汁粉、藤茶、藤茶粉、藤茶提取物中的至少一种;优选的所述藤茶包含藤茶汁、藤茶粉、藤茶提取物中的至少一种。其中藤茶提取物是包含以二氢杨梅素或黄酮类化合物为主要成分的藤茶提取物;优选地,提取物中二氢杨梅素的含量为10%-99.9%,更优选为10%、15%、20%、25%、30%、40%、50%、60%、75%、90%、95%、98%、99%。
本发明第一方面的一个实施方式中,所述组合物还包含选自维生素C和/或其盐和/或其衍生物,果葡糖(糖粉或/和糖浆,下同),葡萄糖,果糖,维生素B6,维生素E中的至少一种;
本发明第一方面的一个实施方式中,所述组合物还包含维生素C和/或其盐和/或其衍生物、果葡糖和/或和葡萄糖/或果糖。
本发明第一方面的一个实施方式中,所述组合物还包含维生素B6。
本发明第一方面的一个实施方式中,所述组合物还包含维生素C衍生物、维生素E。
本发明第一方面的一个实施方式中,包括如下1)至4)中的一项或多项:
1)所述维生素C和/或其盐为0.005~15重量份,优选为0.01~10重量份,例如0.01重量份、0.013重量份、0.02重量份、0.027重量份、0.03重量份、0.033重量份、0.04重量份、0.046重量份、0.05重量份、0.055重量份、0.06重量份、0.066重量份、0.07重量份、0.08重量份、0.083重量份、0.09重量份、0.1重量份、0.11重量份、0.12重量份、0.13重量份、0.14重量份、0.15重量份、0.155重量份、0.16重量份、0.1.8重量份、0.2重量份、0.2.4重量份、0.3重量份、0.3.6重量份、0.38重量份、0.4重量份、0.42重量份、0.5重量份、0.7重量份、1重量份、1.5重量份、2重量份、2.2重量份、2.6重量份、3重量份、3.6重量份、4重量份、4.5重量份、5重量份、6重量份、7重量份、8重量份、9重量份、10重量份;
2)所述果葡糖和/或果糖和/或葡萄糖为1~600重量份,优选为4~400重量份,例如4重量份、7重量份、10重量份、15重量份、23重量份、30重量份、40重量份、50重量份、60重量份、70重量份、80重量份、100重量份、130重量份、140重量份、160重量份、170重量份、180重量份、200重量份、210重量份、230重量份、240重量份、250重量份、270重量份、280重量份、300重量份、320重量份、370重量份、400重量份;
3)所述维生素B6为0.0004~0.3重量份,优选为0.0005~0.2重量份,例如0.0005重量份、0.0006重量份、0.0008重量份、0.001重量份、0.0015重量份、0.002重量份、0.003重量份、0.004重量份、0.005重量份、0.0066重量份、0.008重量份、0.009重量份、份0.01重量份、0.014重量份、0.018重量份、0.02重量份、0.023重量份、0.026重量份、0.03重量份、0.035重量份、0.04重量份、0.047重量份、0.05重量份、0.056重量份、0.06重量份、0.066重量份、0.07重量份、0.076重量份、0.080重量份、0.085重量份、0.09重量份、0.1重量份、0.11重量份、0.12重量份、0.13重量份、0.14重量份、0.15重量份、0.155重量份、0.17重量份、0.18重量份、0.2重量份;
4)所述维生素E为0.001~5重量份,优选为0.003~3重量份,例如0.003重量份、0.004重量份、0.005重量份、0.006重量份、0.008重量份、0.01重量份、0.012重量份、0.016重量份、0.02重量份、0.026重量份、0.03重量份、0.035重量份、0.04重量份、0.046重量份、0.05重量份、0.053重量份、0.06重量份、0.065重量份、0.07重量份、0.076重量份、0.08重量份、0.086重量份、0.09重量份、0.1重量份、0.11重量份、0.12重量份、0.13重量份、0.15重量份、0.156重量份、0.17重量份、0.18重量份、0.2重量份、0.25重量份、0.3重量份、0.33重量份、0.38重量份、0.4重量份、0.46重量份、0.5重量份、0.7重量份、0.8重量份、1重量份、1.2重量份、1.5重量份、1.66重量份、1.9重量份、2重量份、2.2重量份、2.5重量份、2.8重量份、3重量份;
本发明中,所述的维生素C指抗坏血酸或异抗坏血酸中的至少一种。
本发明中,所述的维生素C盐为食品上可接受的维生素C盐或药学上可接受的维生素C盐。包括但不限于维生素C的钠盐、钾盐、钙盐、镁盐、锌盐等等。
本发明中,维生素C衍生物,为食品上可接受的维生素C衍生物或药学上可接受的维生素C衍生物。包括但不限于维生素C磷酸酯、维生素C磷酸盐(如维生素C磷酸酯镁)、维生素C棕榈酸酯、维生素C棕榈酸盐、维生素C琥珀酸酸酯、维生素C琥珀酸酸盐等等。
本发明第一方面的一个实施方式中,所述维生素E选自天然d型α生育酚、天然d型β生育酚、天然d型γ生育酚、天然d型δ生育酚、天然d型α醋酸生育酚、天然d型β醋酸生育酚、天然d型γ醋酸生育酚、天然d型δ醋酸生育酚、天然d型α琥珀酸生育酚、天然d型β琥珀酸生育酚、天然d型γ琥珀酸生育酚、天然d型δ琥珀酸生育酚、混合生育酚、合成dl型α生育酚、合成dl型β生育酚、合成dl型γ生育酚、合成dl型δ生育酚、合成dl型α醋酸生育酚、合成dl型β醋酸生育酚、合成dl型γ醋酸生育酚、合成dl型δ醋酸生育酚、合成dl型α琥珀酸生育酚、合成dl型β琥珀酸生育酚、合成dl型γ琥珀酸生育酚以及合成dl型δ琥珀酸生育酚中的至少一种。
本发明第一方面的一个实施方式中,组合物还包含辅料;优选地,所述辅料选自稀释剂、稳定剂、抗氧化剂、防腐剂、螯合剂、粘合剂、助流剂、矫味剂、着色剂、润湿剂、抗结剂、填充剂、润滑剂、包衣剂(或被膜剂)、崩解剂和载体中的至少一种。
本发明中,所述辅料为食品上可接受的辅料或药学上可接受的辅料。
本发明第二方面涉及一种药物或食品,其包含本发明第一方面中任一所述的组合物。
本发明第二方面的一个实施方式中,所述食品为食品或保健食品。
本发明第二方面的一个实施方式中,所述药物或食品的剂型为饮料、糖果、果冻、片剂、胶囊剂、固体饮料、丸剂。
本发明第三方面涉及制备本发明第一方面中任一所述组合物的方法,其为如下的方法1、方法2;其中,
方法1包括如下步骤:
(1)将枳椇子、番茄分别经榨汁、均质、过滤、离心、加热、溶解中的至少一种工艺处理后,与藤茶,选自维生素C和/或其盐和/或其衍生物、果葡糖、葡萄糖、果糖、维生素B6、维生素E中的至少一种以及选自稀释剂、螯合剂、稳定剂、抗氧化剂中的至少一种进行溶解混合或分步溶解混合,经溶解、离心、过滤、加热、均质中的至少一种工艺处理,得混合物;
(2)将步骤(1)得到的混合物,与选自稀释剂、螯合剂、稳定剂、抗氧化剂、防腐剂、螯合剂、矫味剂、着色剂中的至少一种混合溶解或分步混合溶解,经离心、过滤、均质、冷藏、沉淀、灭菌中的至少一种工艺处理,得混合物;
优选地,方法1中,枳椇子包含枳椇子鲜果、枳椇子果汁、枳椇子提取物中的至少一种;番茄包含番茄鲜果、番茄果汁、番茄提取物中的至少一种;藤茶包含藤茶汁、藤茶汁粉、藤茶提取物中的至少一种。还包括选自维生素C、维生素C盐、果葡糖、葡萄糖、果糖、维生素B6中的至少一种共同混合。
方法2包括如下步骤:
将枳椇子、番茄、藤茶,与选自稀释剂、稳定剂、抗氧化剂、防腐剂、粘合剂、助流剂、矫味剂、着色剂、润湿剂、抗结剂、填充剂、润滑剂、包衣剂(或被膜剂)、崩解剂和载体中的至少一种混合或分步混合。
优选地,方法2中,还包括加入选自维生素C和/或其盐和/或其衍生物,果葡糖,葡萄糖,果糖,维生素B6,维生素E中的至少一种共同混合。
本发明第四方面涉及本发明第一方面中任一所述的组合物在制备抗氧化和/或辅助抗氧化的药物中的用途或者在制备酒精性肝损伤和/或辅助治疗酒精性肝损伤药物中的用途。
本发明第五方面涉及本发明第一方面中任一所述的组合物在制备抗氧化的食品中的用途或者在制预防和/或改善由饮酒等引起的头晕、嗜睡、呕吐等不适症状的食品中的用途或者在制备预防和/或改善酒精性肝损伤的食品中的用途;
优选地,所述食品为保健食品。
如下文献的全文并入本发明:
NY/T 957番茄粉
NY/T 956番茄酱
GB 28316食品安全国家标准食品添加剂番茄红
GB1886.78食品安全国家标准食品添加剂番茄红素(合成)
T/CCCMHPIE 1.28植物提取物番茄红素
GB 14753食品安全国家标准食品添加剂维生素B6(盐酸吡哆醇)
GB14754食品安全国家标准食品添加剂维生素C(抗坏血酸)
GB 1886.44食品安全国家标准食品添加剂抗坏血酸钠
GB 1886.28食品安全国家标准食品添加剂D-异抗坏血酸钠
GB 1886.230食品安全国家标准食品添加剂抗坏血酸棕榈酸酯
GB 1903.24食品安全国家标准食品营养强化剂维生素C磷酸酯镁
YY 0036食品添加剂维生素C磷酸酯镁
GB1886.233食品安全国家标准食品添加剂维生素E
GB/T 26762结晶果糖、固体果葡糖
GB/T 20882果葡糖浆
GB/T 20880食用葡萄糖
GB/T 20885葡萄糖浆
GB/T 317白砂糖
T/CNFIA 110红糖
GB 25531食品安全国家标准食品添加剂三氯蔗糖
GB 1886.182食品安全国家标准食品添加剂异麦芽酮糖
QB/T 4486异麦芽酮糖醇
GB 1886.172食品安全国家标准食品添加剂迷迭香提取物
QB/T 2817食品添加剂迷迭香提取物
GB 30615食品安全国家标准食品添加剂竹叶抗氧化物
SB/T 10198浓缩果汁通用技术条件
GB 1886.87食品安全国家标准食品添加剂蜂蜡
GB/T 24314蜂蜡
SB/T 10190蜂蜡
GB 1886.235食品安全国家标准食品添加剂柠檬酸
GB 1886.25-食品安全国家标准食品添加剂柠檬酸钠
GB/T 38573预糊化淀粉
GB 31637食品安全国家标准食用淀粉
GB 15203食品安全国家标准淀粉糖
GB/T 20884麦芽糊精
GB 1886.91食品安全国家标准食品添加剂硬脂酸镁
GB 25576食品安全国家标准食品添加剂二氧化硅
GB 25533食品安全国家标准食品添加剂果胶
GB 1886.181食品安全国家标准食品添加剂红曲红
GB 1886.19食品安全国家标准食品添加剂红曲米
GB 2716食品安全国家标准植物油
GB 25557食品安全国家标准食品添加剂焦磷酸钠
GB 30616食品安全国家标准食品用香精
卫生卫计委关于批准壳寡糖等6种新食品原料的公告(2014年第6号)
***关于指定D-甘露糖醇等58个食品添加剂产品标准的公告(2011年第8号)
本发明取得的有益效果:
本发明组合物具有抗氧化的功能,组合物原料间有协同作用,能增强整体抗氧化效果。并且,本发明组合物对酒精性肝损伤有改善治疗作用,对饮酒引起的不适症状有良好改善效果。
具体实施方式
以下的实施例、对比例及测试例中使用的材料和试剂如下:
枳椇子果汁:购买自宁夏凯源生物技术有限公司;
枳椇子果汁粉:由枳椇子果汁经干燥自制;
枳椇子粉:购买自安徽馨之源生物科技有限公司;
枳椇子提取物:购买自西安天丰生物科技股份有限公司;
藤茶汁:由腾茶鲜叶经打浆过滤自制;
藤茶汁粉(含二氢杨梅素15%):由腾茶汁经干燥自制;
藤茶粉(含二氢杨梅素25%):购买自湖南甜蔓生物科技有限公司;
藤茶提取物(含二氢杨梅素75%):购买自湖南甜蔓生物科技有限公司;
藤茶提取物(含二氢杨梅素98%):购买自湖南甜蔓生物科技有限公司;
番茄果汁:购买自漳浦县达川食品工业有限公司;
番茄粉:购买自江西雅班那工业有限公司;
番茄提取物(含番茄红素2%,粉):购买自晨光生物科技集团股份有限公司公司;
番茄提取物(含番茄红素10%,粉):购买自晨光生物科技集团股份有限公司公司;
番茄提取物(含番茄红素20%,油树脂):购买自新疆科宇科技公司;
番茄提取物(含番茄红素95%,晶体):购买自乐康瑞德食品添加剂(常州)有限公司;
维生素C(抗环血酸):购买自郑州福润德生物工程有限公司;
维生素C钙(抗环血钙):购买自郑州福润德生物工程有限公司;
维生素C钠(抗环血酸钠):购买自郑州福润德生物工程有限公司;
维生素C钾(抗环血酸钾):购买自郑州福润德生物工程有限公司;
维生素C棕榈酸酯:购买自郑州福润德生物工程有限公司;
维生素C磷酸酯镁:购买自郑州福润德生物工程有限公司;
维生素E:购买自帝斯曼集团;
维生素B6:购买自郑州福润德生物工程有限公司;
果葡糖浆:购买自江苏先卓食品科技股份有限公司;
固体果葡糖:购买自西王药业有限公司;
果糖:购买自山东通升食品配料有限公司;
葡萄糖:购买自山东通升食品配料有限公司;
蔗糖:购买自山东通升食品配料有限公司;
三氯蔗糖:购买自盐城捷康三氯蔗糖制造有限公司
异麦芽酮糖:购买自山东福田药业有限公司;
异麦芽酮糖醇:购买自山东福田药业有限公司;
迷迭香提取物:购买自广州合诚实业有限公司;
竹叶抗氧化物:购买自浙江圣氏生物科技有限公司;
杨梅汁:购买自漳浦县达川食品工业有限公司;
百香果汁:购买自漳浦县达川食品工业有限公司;
蜂蜡:购买自山东东光县隆祥蜂蜡制品有限公司;
小烛树蜡:购买自广州佳琪生物科技有限公司;
柠檬酸:购买自潍坊英轩实业有限公司;
柠檬酸钠:购买自潍坊英轩实业有限公司;
果冻粉:购买自江苏鑫和源生物科技有限公司;
预糊化淀粉:购买自德州高峰淀粉有限公司;
淀粉:购买自罗盖特(中国)精细化工有限公司;
麦芽糊精:购买自罗盖特(中国)精细化工有限公司;
硬脂酸镁:购买自安徽山河药用辅料股份有限公司;
二氧化硅:购买自安徽山河药用辅料股份有限公司;
包衣粉(被膜剂):购买自温州小伦包衣技术有限公司;
果胶:购买自山东安德利集团有限公司;
食用着色剂::购买自上海染料研究所有限公司;
红曲米:购买自杭州天曲生物技术有限公司;
精炼植物油:购买自益海嘉里集团;
水飞蓟籽油:购买自西安瑞尔丽生物工程有限公司;
焦磷酸钠:购买自湖北兴发化工集团股份有限公司;
水果香精:购买自杭州百瑞香精香料有限公司;
清凉剂香精:购买自杭州百瑞香精香料有限公司。
实施例1
将2.5Kg枳椇子果汁、1.2Kg藤茶汁、800g番茄果汁、250g百香果汁,和适量纯化水混匀离心后,清液中加入4Kg果葡糖浆,并加热至70-85℃水,混合均匀,过滤备用。将75g果胶、100g异麦芽酮糖、45g柠檬酸、5g柠檬酸钠,和适量70-85℃纯化水混合,经均质溶解后,与上述过滤后的溶液混合,搅拌均匀;加入100g维生素C钠(抗坏血酸钠)、2g维生素B6、4g竹叶抗氧化物,搅拌溶解,定容至25L,最后加入15g水果香精、4g清凉剂香精,搅拌均匀后经灌装,灭菌,得到饮料产品1。
实施例2
将15Kg枳椇子果汁、25Kg番茄果汁、10Kg杨梅汁、5Kg百香果汁,和适量纯化水混匀离心,在清液中加入400g果葡糖浆、17Kg果糖、50g三氯蔗糖、400g藤茶提取物(98%)、250g焦磷酸钠,并加热至70-85℃水,混合均匀,过滤备用。将1.5Kg果胶、700g柠檬酸、100g柠檬酸钠、12.6Kg葡萄糖,和适量70-85℃纯化水混合,经均质溶解后,与上述过滤后的溶液混合,搅拌均匀,然后加入250g维生素C(抗坏血酸)、30g竹叶抗氧化物;0.8g维生素B6;搅拌溶解,定容至50L,最后加250g水果香精、100g清凉剂香精,搅拌均匀后经灌装,灭菌,得到饮料产品2。
实施例3
将8.5Kg枳椇子粉、9Kg藤茶提取物(98%)、15Kg番茄提取物(10%,粉)、9.4Kg预糊化淀粉、32Kg固体果葡糖、5Kg维生素C、0.6Kg红曲米、80g柠檬酸钠、20g柠檬酸,置于混合机中混合均匀,将混匀后的混合物经制粒后与400g硬脂酸镁总混,总混颗粒经填充胶囊得到硬胶囊1,或将总混颗粒压片并用1.2Kg包衣粉(被膜剂)包衣,得到片剂1。
实施例4
将0.75Kg枳椇子提取物、8.5Kg藤茶提取物(98%)、625g番茄提取物(2%)、500g维生素B6、4.925Kg淀粉、2Kg维生素C磷酸酯镁、80g柠檬酸钠、20g柠檬酸、100g二氧化硅置于混合机中混合均匀,将混匀后的混合物经制粒后经填充胶囊得到硬胶囊2,或将混匀后的混合物添加必要辅料经制丸工艺做成丸剂1。
实施例5
将5Kg枳椇子果汁粉、5Kg藤茶汁粉(15%)、3Kg番茄粉、21Kg固体果葡糖、2.5Kg果胶、130g三氯蔗糖、125g维生素C钙(抗坏血酸钙)、1Kg异麦芽酮糖醇、10.535Kg麦芽糊精、1Kg柠檬酸、500g二氧化硅、210g水果香精,置于混合机中混合均匀,将混匀后的混合物包装得到粉状固体饮料1;也可将混合物进行制粒后包装得到颗粒状固体饮料2.
实施例6
将2.4Kg蜂蜡与10kg精炼植物油置于配料罐中加热至65±5℃,搅拌溶解,加入38.05Kg精炼植物油,搅拌均匀,保温40±5℃,加入5.4Kg枳椇子提取物、450g藤茶提取物(50%)、5Kg维生素C棕榈酸酯、2.7Kg维生素E、6Kg番茄提取物(20%,油树脂),搅匀后经胶体磨分散并搅拌均匀,得到内容物料液。将内容物料液置于软胶囊压丸机上,用配好的软胶囊壳胶液,进行压丸,经定型、干燥、拣丸等工艺得到软胶囊1。
实施例7
将2Kg小烛树蜡与12kg水飞蓟籽油置于配料罐中加热至65±5℃,搅拌溶解,加入35.28Kg水飞蓟籽油、2Kg番茄提取物(95%,晶体磨粉)、12g维生素E、400g维生素B6、16g维生素C棕榈酸酯、300g迷迭香提取物,搅拌均匀,保温35±5℃,加入1.5Kg枳椇子提取物、6.5Kg藤茶提取物(75%)、搅匀后经100目筛并搅拌均匀,得到内容物料液。将内容物料液置于软胶囊压丸机上,用配好的软胶囊壳胶液,进行压丸,经定型、干燥、拣丸等工艺得到软胶囊2。
实施例8
将12Kg果葡糖浆、25Kg纯化水、7Kg蔗糖置于熬糖罐中,煮沸熬煮搅拌。用5Kg冷纯化水与2Kg果冻粉混合,加入熬糖罐中继续熬煮搅拌,过滤后转入配料罐,75-90℃保温并搅拌。将0.5Kg藤茶粉(25%)、6Kg枳椇子果汁、3Kg番茄果汁、3Kg水混匀后加入配料罐,搅拌乳化均匀。将14g维生素C钾(抗环血酸钾)、0.4g维生素B6、100g柠檬酸,15g柠檬酸钠、8g食用着色剂用3Kg水溶解后,加入配料罐混匀,加入40g水果香精搅拌混匀过滤后包装,灭菌、冷却得到果冻1。
对比例1(空白对照)
实施例3中的枳椇子粉、藤茶提取物、番茄提取物、固体果葡糖、维生素C均用相同重量的预糊化淀粉替换,其余和实施例3中片剂制法相同,得到片剂2。
对比例2(枳椇子对照)
实施例3中的藤茶提取物、番茄提取物、固体果葡糖、维生素C均用相同重量的预糊化淀粉替换,其余和实施例3中片剂制法相同,得到片剂3。
对比例3(枳椇子+藤茶提取物对照)
实施例3中的番茄提取物、固体果葡糖、维生素C均用相同重量的预糊化淀粉替换,其余和实施例3中片剂制法相同,得到片剂4。
对比例4(枳椇子+番茄提取物对照)
实施例3中的藤茶提取物、固体果葡糖、维生素C均用相同重量的预糊化淀粉替换,其余和实施例3中片剂制法相同,得到片剂5。
测试例1:小鼠抗氧化功能试验研究
1.试验药物:
对比例1中的片剂2组合物(空白组,代号A1);
对比例2中的片剂3组合物(枳椇子组,代号B);
对比例3中的片剂4组合物(枳椇子+藤茶提取物组,代号C);
对比例4中的片剂5组合物(枳椇子+番茄提取物组,代号D)。
实施例3中的片剂1组合物(产品组,代号E1);
2.试验方法:
选用11月龄的老龄小鼠,试验前取尾血,测丙二醛MDA值,按MDA水平随机分为:A1组(空白组,片剂2组合物)、B组(枳椇子组,片剂3组合物)、C组(枳椇子+藤茶提取物组,片剂4组合物)、D组(枳椇子+番茄提取物组,片剂5组合物)、E1组(产品组,片剂1组合物),每组8只。
各组灌胃给样品,每天一次,连续30天。试验结束时称量体重后,处死实验小鼠,取肝组织,液氮冷冻,-40℃保存。测定超氧化物歧化酶(SOD)、还原性谷胱甘肽(GSH)、丙二醛(MDA)、和蛋白羰基含量值。
3.试验结果:
小鼠抗氧化功能试验各项结果如下,
由表2数据可知,各组小鼠试验初期、试验中期、及试验终期的体重没有变化,说明产品对小鼠体重没什么影响。
注:aP<0.05vs A1组(空白组),bP<0.05vs B组(枳椇子组),cP<0.05vs C组(枳椇子+藤茶提取物组),dP<0.05vsD组(枳椇子+番茄提取物组)
由表3数据可知,B组(枳椇子组,对比例2,片剂3)对A1组(空白组,对比例1,片剂2)在肝组织SOD活力、蛋白质羰基含量指标,差异性显著;C组(枳椇子+藤茶提取物组,对比例3,片剂4)对B组(枳椇子组)在肝组织MDA、SOD活力指标差异性显著;D(枳椇子+番茄提取物组,对比例4,片剂5)对C组(枳椇子+藤茶提取物组)在肝组织SOD活力和蛋白质羰基含量指标差异性显著,E1组(产品组,实施例3,片剂1)对D(枳椇子+番茄提取物组)在肝组织SOD活力和GSH含量指标差异性显著。说明产品既有抗氧化效果,且组合物之间具有协同作用,能增强整体抗氧化效果。
测试例2:抗氧化功能人体试验研究
1.试验药物:
对比例1中的片剂2组合物(空白组,代号A2组);
实施例3中的片剂1组合物(产品组,代号E2组);
维生素E软胶囊(阳性对照组,代号F组;青岛双鲸药业股份有限公司,国药准字H37023085)
2.试验方法:
选择年龄18~65岁,身体健康状况良好,无明显脑、心、肝、肺、肾、血液疾患,无长期服药史,志愿受试保证配合的人群。排除(1)妊娠或哺乳期妇女,对番茄红素过敏者;(2)合并有心、肝、肾和造血***等严重疾病患者;(3)短期内服用与受试功能有关的物品,影响对结果的判断者;(4)不符合纳入标准,未按规定服食受试样品,无法判定功效或资料不全影响功效或安全性判断者。
试验采用双盲随机分组、组间和自身两种对照设计。试验共入选70例受试者,受试者按丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)水平随机分为3组,其中A2组23例,F组23例,E2组24例。
试食期间保持平日的生活和饮食***变化等。
3.试验结果:
人体抗氧化功能试验各项结果如下(过程中A2组和E2组各脱除1例):
注:*P<0.05vs试食前,aP<0.05vs A2组,bP<0.05vs F组。
由表4可以看出:E2组(产品组,实施例3,片剂1)在试食试验过程中MDA水平的下降幅度,相对A2组(空白组,对比例1,片剂2)和F组(阳性对照组,维生素E软胶囊,国药准字H37023085)均有显著性差异。
注:*P<0.05vs试食前,aP<0.05vs A2组,bP<0.05vs F组。
由表5数据可知:E2组(产品组,实施例3,片剂1)在试食试验后SOD水平以及试验前后SOD上升幅度,相对A2组(空白组,对比例1,片剂2)和F组(阳性对照组,维生素E软胶囊,国药准字H37023085)均有显著性差异。
注:*P<0.05vs试食前,aP<0.05vs A2组,bP<0.05vs F组。
由表6:E2组(产品组,实施例3,片剂1)在试食试验前后GSH-Px升高幅度,相对A2组(空白组,对比例1,片剂2)和F组(阳性对照组,维生素E软胶囊,国药准字H37023085)均有显著性差异。
以上各组数据表明,产品(E2组,实施例3,片剂1)在人体内具有抗氧化的功能,且效果优于F组(阳性对照组,维生素E软胶囊,国药准字H37023085)。
测试例3:小鼠酒精性肝损伤试验研究
1.试验药物:
纯净水(空白组,代号K组);
实施例3中的片剂1组合物(产品组,代号E3组);
海王金樽片(阳性对照组,代号Y组,深圳市海王健康科技发展有限公司;卫食健字(2002)第0396号)
2.试验方法:
1)选用健康成年的小鼠,18只,分成3组每组6只,空腹分别灌胃0.12ml/10g·bw、0.15ml/10g·bw、0.18ml/10g·bw的52°红星二锅头白酒,根据动物步态和活动情况、醉酒时间、翻正反射情况等,确定小鼠醉酒量0.15ml/10g·bw。
2)选用健康成年的小鼠,40只,每组10只,分成4组,分别为:K组(空白组,灌服纯净水)、M组(模型组,醉酒后灌服纯净水)、E3组(产品组,醉酒后灌服实施例3的片剂1)、Y组(阳性对照组,醉酒后灌食海王金樽片)。
记录实验过程中醉酒时间。试验结束时,处死实验小鼠,取肝组织,液氮冷冻,-40℃保存。测定血清中谷草转氨酶(AST)、谷丙转氨酶(ALT)活力水平,以及肝组织丙二醛(MDA)、还原性谷胱甘肽(GSH)、和甘油三酯(TG)水平。
3.试验结果:
小鼠酒精性肝损伤试验结果如下:
注:*P<0.05vs M组。
通过表7结果可知,不管是小鼠的酒精耐受时间还是酒醉的维持时间,产品组(E3组)和阳性对照组(Y组)均和模型组(M组)有显著差异,具有良好的解酒/缓解酒后症状的作用,且产品组(E3组)优于阳性对照组(Y组),但无差异显著性。
注:*P<0.05vs K组,aP<0.05vs M组,bP<0.01vs M组。
由表8可知,产品组(E3组)、阳性对照组(Y组)对比模型组(M组),在降低谷草转氨酶(AST)和谷丙转氨酶(ALT),保护肝细胞损伤方面有良好的效果,且产品组(E3组)优于阳性对照组(Y组),AST无差异显著性,ALT差异明显。
注:*P<0.05vs K组,aP<0.05vs M组。
由表9可知,产品组(E3组)、阳性对照组(Y组)对比模型组(M组),在肝组织丙二醛(MDA)、还原性谷胱甘肽(GSH)和甘油三酯(TG)指标均有显著差异,说明在保护肝脏、对抗脂肪肝方面有良好的作用。产品组(E3组)和阳性对照组(Y组)间无明显差异。
以上各组数据表明,产品组(E3组,实施例3,片剂1)具有保护酒精性肝损伤的作用,对小鼠醉酒的症状有缓解效果,且效果整体优于阳性对照组。
测试例4:醉酒症状人体试食试验研究
1.试验药物:
实施例3中的片剂1组合物(产品组,代号E4组);
海王金樽片(阳性对照组,代号Y’组,深圳市海王健康科技发展有限公司;卫食健字(2002)第0396号)
2.试验方法:
选择浙江某市男性自愿者39名,年龄在35~40岁之间,进行体检证实无任何器质性疾病和酒精过敏症状。
试验过程:
1)醉酒量测试试验(试验编号1))
所有受试人员试验前未服用任何产品,在指定时间进食泸州老窖(52°白酒)和准备的食物,至酒醉,观察受试者动作,言语等,记录醉酒嗜睡时间,以及酒醒后感受,醉酒症状完全消失时间等,且在醉酒2h测定静脉血液中乙醇浓度。
2)醒酒试验(试验编号2))
上述酒量测试试验进行一周后,在同一地点、时间进行醒酒试验,确认健康状况良好,排除感冒生病等受试者。
将受试者随机分成2组,分别为:①产品组(E4组)20人:醉酒前30min先温水吞服实施例3的片剂1,醉酒后如口渴只喝纯净水,不进食其他任何食物或饮品;②阳性对照组(Y’组)19人:醉酒前30min先温水吞服海王金樽片,醉酒后如口渴只喝纯净水,不进食其他任何食物或饮品。在与上次同样指定时间,饮用各自上次记录醉酒量的相同白酒,进食相同品种相同量的食物,观察受试者动作,言语等,记录醉酒嗜睡时间,以及酒醒后感受,醉酒症状完全消失时间等,且在醉酒2h测定静脉血液中乙醇浓度。
3.试验结果:
小鼠酒精性肝损伤试验结果如下:
注:*P<0.05vs试验1)。
通过表9结果可知,产品组(E4组)和阳性对照组(Y’组)可一定程度的降低酒后2h静脉血液中乙醇的浓度,但效果不明显;两组均可以缩短醉酒的嗜睡时间和酒后症状的完全恢复时间;产品组(E4组)对醉酒睡醒后的头晕症状也有明显改善,说明产品对缓解酒后症状有良好的效果。
显然,上述实施例仅仅是为清楚地说明所作的举例,而并非对实施方式的限定。对于所属领域的普通技术人员来说,在上述说明的基础上还可以做出其它不同形式的变化或变动。这里无需也无法对所有的实施方式予以穷举。而由此所引伸出的显而易见的变化或变动仍处于本发明创造的保护范围之中。
Claims (10)
1.一种组合物,包含:枳椇子0.2~280重量份;番茄0.2~300重量份;藤茶0.1~150重量份。
2.根据权利要求1所述的组合物,其包含:枳椇子0.3~250重量份;番茄0.25~250重量份;藤茶0.15~120重量份。
3.根据权利要求1或2所述的组合物,其还包含选自维生素C和/或其盐和/或其衍生物,果葡糖(糖粉或/和糖浆),葡萄糖,果糖,维生素B6,维生素E中的至少一种;优选地,所述组合物还包含维生素C。
4.根据权利要求3所述的组合物,其特征在于如下1)至4)中的一项或多项:
1)所述维生素C和/或其盐和/或其衍生物为0.005~15重量份;更优选地,所述维生素C和/或其盐和/或其衍生物为0.01~10重量份;
2)所述果葡糖和/或果糖和/或葡萄糖为1~600重量份,优选为4~400重量份;
3)所述维生素B6为0.0004~0.3重量份,优选为0.0005~0.2重量份;
4)所述维生素E为0.001~5重量份,优选为0.003~3重量份。
5.根据权利要求1至4中任一项所述的组合物,其还包含辅料;优选地,所述辅料选自稀释剂、稳定剂、抗氧化剂、防腐剂、螯合剂、粘合剂、助流剂、矫味剂、着色剂、润湿剂、抗结剂、填充剂、润滑剂、包衣剂(或被膜剂)、崩解剂和载体中的至少一种。
6.一种药物或食品,包含权利要求1至5任一项所述的组合物;优选地,所述食品为食品;优选地,所述药物或食品的剂型为饮料、糖果、果冻、片剂、胶囊剂、固体饮料。
7.根据权利要求1或2所述的组合物;其特征在于:
1)所述枳椇子包含枳椇子鲜果以及由其加工而成的枳椇子果汁(原汁和/或浓缩汁)、枳椇子果酱、枳椇子果汁粉、枳椇子粉、枳椇子提取物中的至少一种;
优选的所述枳椇子包含枳椇子果汁、枳椇子粉、枳椇子提取物中的至少一种;
2)所述番茄包含番茄鲜果以及由其加工而成的番茄果汁(原汁和/或浓缩汁)、番茄果酱、番茄粉、番茄提取物中的至少一种;
优选的所述番茄包含番茄果汁、番茄粉、番茄提取物中的至少一种;
3)所述藤茶包含鲜藤茶以及由其嫩叶加工而成的藤茶汁(原汁和/或浓缩汁)、藤茶汁粉、藤茶、藤茶粉、藤茶提取物中的至少一种;
优选的所述藤茶包含藤茶汁、藤茶粉、藤茶提取物中的至少一种。
8.制备权利要求1至5任一项所述组合物的方法为如下的方法1、方法2;其中,
方法1包括如下步骤:
(1)将枳椇子、番茄分别经榨汁、均质、过滤、离心、加热、溶解中的至少一种工艺处理后,与藤茶,选自维生素C和/或其盐和/或其衍生物、果葡糖、葡萄糖、果糖、维生素B6、维生素E中的至少一种以及选自稀释剂、螯合剂、稳定剂、抗氧化剂中的至少一种进行溶解混合,经溶解、离心、过滤、加热、均质中的至少一种工艺处理,得混合物;
(2)将步骤(1)得到的混合物,与选自稀释剂、螯合剂、稳定剂、抗氧化剂、防腐剂、螯合剂、矫味剂、着色剂中的至少一种混合溶解或分步混合溶解,经离心、过滤、均质、冷藏、沉淀、灭菌中的至少一种工艺处理,得混合物;
优选地,方法1中,枳椇子包含枳椇子鲜果、枳椇子果汁、枳椇子提取物中的至少一种;番茄包含番茄鲜果、番茄果汁、番茄提取物中的至少一种;藤茶包含藤茶汁、藤茶提取物中的至少一种。还包括选自维生素C、维生素C盐、果葡糖、葡萄糖、果糖、维生素B6中的至少一种共同混合。
方法2包括如下步骤:
将枳椇子、番茄、藤茶,与选自稀释剂、稳定剂、抗氧化剂、防腐剂、粘合剂、助流剂、矫味剂、着色剂、润湿剂、抗结剂、填充剂、润滑剂、包衣剂(或被膜剂)、崩解剂和载体中的至少一种混合或分步混合。
优选地,方法2中,还包括加入选自维生素C和/或其盐和/或其衍生物,果葡糖,葡萄糖,果糖,维生素B6、维生素E中的至少一种共同混合。
9.权利要求1至5任一所述组合物在制备抗氧化和/或辅助抗氧化的药物中的用途或者在制备酒精性肝损伤和/或辅助治疗酒精性肝损伤药物中的用途。
10.权利要求1至6中任一所述组合物在制备抗氧化的食品中的用途或者在制预防和/或改善由饮酒等引起的头晕、嗜睡、呕吐等不适症状的食品中的用途或者在制备预防和/或改善酒精性肝损伤的食品中的用途;
优选地,所述食品为保健食品。
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