CN112587708A - Collagen peptide wound dressing and preparation method thereof - Google Patents
Collagen peptide wound dressing and preparation method thereof Download PDFInfo
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- CN112587708A CN112587708A CN202110004281.8A CN202110004281A CN112587708A CN 112587708 A CN112587708 A CN 112587708A CN 202110004281 A CN202110004281 A CN 202110004281A CN 112587708 A CN112587708 A CN 112587708A
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
- A61L15/325—Collagen
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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Abstract
The invention discloses a collagen peptide wound dressing and a preparation method thereof, wherein the collagen peptide wound dressing comprises, by weight, 25% -35% of collagen, 10% -15% of lactoferrin, 8% -12% of bone glue, 8% -14% of polyvinylpyrrolidone, 8% -12% of oat glue, 5% -8% of anthocyanin, 3% -5% of medlar, 3% -5% of pseudo-ginseng, 4% -6% of Japanese thistle herb, 2% -4% of honey, 1% -2% of vitamin and 3% -5% of corn starch. The collagen peptide wound dressing is mainly prepared from collagen and lactoferrin, and has the advantages of simple process and low preparation cost; the polyvinylpyrrolidone, the pseudo-ginseng and the Japanese thistle can achieve the effects of detoxifying, stopping bleeding, improving the dissolved concentration, preventing peritoneal adhesion, promoting blood sedimentation and the like, various vitamins are added to ensure nutrition and absorption, and a small amount of honey enables the anti-corrosion performance to be good, so that bacterial infection can be organized.
Description
Technical Field
The invention relates to the technical field of collagen peptide, in particular to a collagen peptide wound dressing and a preparation method thereof.
Background
The dermis layer of the skin contains abundant collagen, which is a transparent gelatinous substance consisting of 3 strands of spiral fibers and is the main structural protein in connective tissues, and the collagen and the elastin are orderly arranged and are mutually connected to form a net-shaped structure, so that the dermis layer supports the plumpness of the skin like a steel bar framework of a building. The elasticity of collagen maintains the elasticity and self-recovery property of skin. The collagen also adsorbs a large amount of water molecules, prevents water evaporation, and keeps the skin moist and glossy. Collagen accounts for 70-80% of the dry weight of the skin, is an important structural component of the skin, and is an indispensable nutrient and protective agent. Hydroxyproline in collagen is a key substance of skin connective tissue, and fibrous collagen forms a net structure to provide support for the tension and elasticity of the skin. Collagen in the dermis is also a nutrient supply station for the epidermis and skin appendages, and maintains the environmental stability in the skin and the supply of moisture and nutrients to skin tissues. Thus, collagen is not isolated from skin for growth, repair, and nutrition. Collagen also plays an important role in delaying aging.
The traditional collagen peptide wound dressing can only temporarily protect a wound and prevent wound infection, but does not have the functions of hemostasis, healing and the like, and the traditional processing technology is complex. Therefore, a new technical solution needs to be provided.
Disclosure of Invention
The invention aims to provide a collagen peptide wound dressing and a preparation method thereof, which solve the problems that the traditional collagen peptide wound dressing in the prior art can only temporarily protect a wound and prevent wound infection, but does not have the functions of hemostasis, healing and the like, and the traditional processing technology is complex.
In order to achieve the purpose, the invention provides the following technical scheme: a collagen peptide wound dressing and a preparation method thereof comprise the following raw materials, by weight, 25% -35% of collagen, 10% -15% of lactoferrin, 8% -12% of bone glue, 8% -14% of polyvinylpyrrolidone, 8% -12% of oat glue, 5% -8% of anthocyanin, 3% -5% of wolfberry, 3% -5% of pseudo-ginseng, 4% -6% of Japanese thistle herb, 2% -4% of honey, 1% -2% of vitamin and 3% -5% of corn starch.
The collagen protein powder comprises, by weight, 30% of collagen, 12% of lactoferrin, 10% of bone glue, 11% of polyvinylpyrrolidone, 10% of oat glue, 6% of anthocyanin, 4% of medlar, 4% of pseudo-ginseng, 5% of Japanese thistle herb, 3% of honey, 1% of vitamin and 4% of corn starch.
In a preferred embodiment of the present invention, the collagen is an extract of animal bones such as fish skin, fish scales, and yak bones.
As a preferred embodiment of the present invention, the vitamin is a combination of vitamin a, vitamin B, vitamin D and vitamin E.
As a preferred embodiment of the present invention, the honey is all-flower honey, longan honey, rape flower honey, loquat honey, orange honey, lychee honey, sophora flower honey, chastetree honey, jujube flower honey, etc. Wherein the common northern part is one or more of Chinese date honey, sophora flower honey, wattle honey and all-flower honey.
As a preferred embodiment of the present invention, the preparation method comprises the steps of:
step 1: selecting fish scales or fish skins or other animal bones as raw materials, adding purified water, steaming to obtain a treated material, cooling the treated material to 55-57 ℃, adding lipase, stirring for enzymolysis for 20-40 min, then adding chymotrypsin and ficin, stirring for enzymolysis for 3-4 h, and inactivating enzymes after enzymolysis is finished to obtain an enzymolysis liquid; separating, purifying and drying the enzymolysis liquid to obtain collagen peptide;
step 2: decocting the medlar, the pseudo-ginseng and the Japanese thistle in water respectively for 1-2 h, sieving the obtained liquid medicine to remove impurities, and obtaining pure liquid medicine in a distillation mode;
step 3, adding lactoferrin into the collagen peptide obtained in the step 1, putting the collagen peptide into a mixer, stirring and mixing, heating in the mixing process, fully mixing, adding bone glue, polyvinylpyrrolidone, oat glue, anthocyanin, honey, vitamins and corn starch, and fully stirring to form paste sticky matter;
and 4, step 4: adding the liquid medicine and vitamins obtained in the step 2 into the paste-like sticky matter obtained in the step 3, fully mixing, putting into an emulsifying machine for emulsifying at a certain temperature, and homogenizing the emulsified slurry by a high-pressure homogenizer to obtain an emulsified liquid;
and 5: and (4) introducing the emulsion obtained in the step (4) into a mould after ultrasonic defoaming, standing for 24-48 h at normal temperature, and finally freeze-drying to obtain the collagen peptide wound dressing.
In a preferred embodiment of the present invention, the temperature is raised during the mixing in step 3, and the temperature is raised by: 75-85 ℃.
As a preferred embodiment of the present invention, the emulsification temperature in step 4 is: 70-80 ℃.
Compared with the prior art, the invention has the following beneficial effects:
the collagen peptide wound dressing is mainly prepared from collagen and lactoferrin, and has the advantages of simple process and low preparation cost; the polyvinylpyrrolidone, the pseudo-ginseng and the Japanese thistle can achieve the effects of detoxifying, stopping bleeding, improving the dissolution concentration, preventing peritoneal adhesions, promoting blood sedimentation and the like. The oat gum has the main components of beta-glucan, has the effects of reducing blood fat and serum cholesterol, has important effects of preventing and treating cardiovascular and cerebrovascular diseases and diabetes, has super-strong oxidation resistance which is 50 times of vitamin E and 20 times of vitamin C, can delay aging and prevent arteriosclerosis, is added with various vitamins to ensure nutrition and absorption, has good corrosion resistance due to the addition of a small amount of honey, and can organize bacterial infection.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
The invention provides a collagen peptide wound dressing and a preparation method thereof, wherein the collagen peptide wound dressing comprises the following raw materials, by weight, 35% of collagen, 15% of lactoferrin, 12% of bone glue, 14% of polyvinylpyrrolidone, 12% of oat glue, 8% of anthocyanin, 5% of wolfberry, 5% of pseudo-ginseng, 6% of Japanese thistle herb, 4% of honey, 2% of vitamin and 5% of corn starch.
In a further improvement, the collagen is an extract of animal bones such as fish skin or fish scales, depleted beef bones and the like.
In a further improvement, the vitamin is a combination of vitamin a, vitamin B, vitamin D and vitamin E.
In a further improvement, the honey is all-flower honey, longan honey, rape flower honey, loquat honey, orange honey, lychee honey, sophora flower honey, chastetree fruit honey, jujube flower honey and the like.
Wherein the common northern part is one or more of Chinese date honey, sophora flower honey, wattle honey and all-flower honey.
The preparation method comprises the following steps:
step 1: selecting fish scales or fish skins as raw materials, adding purified water, cooking to obtain a processed material, cooling the processed material to 57 ℃, adding lipase, stirring and performing enzymolysis for 40min, then adding chymotrypsin and ficin, stirring and performing enzymolysis for 4h, and inactivating enzymes after the enzymolysis is finished to obtain an enzymolysis liquid; separating, purifying and drying the enzymolysis liquid to obtain collagen peptide;
step 2: decocting fructus Lycii, Notoginseng radix and herba seu radix Cirsii Japonici in water for 2 hr, sieving the obtained medicinal liquid to remove impurities, and distilling to obtain pure medicinal liquid;
step 3, adding lactoferrin into the collagen peptide obtained in the step 1, putting the collagen peptide into a mixer, stirring and mixing, heating in the mixing process, fully mixing, adding bone glue, polyvinylpyrrolidone, oat glue, anthocyanin, honey, vitamins and corn starch, and fully stirring to form paste sticky matter;
and 4, step 4: adding the liquid medicine and vitamins obtained in the step 2 into the paste-like sticky matter obtained in the step 3, fully mixing, putting into an emulsifying machine for emulsifying at a certain temperature, and homogenizing the emulsified slurry by a high-pressure homogenizer to obtain an emulsified liquid;
and 5: and (4) introducing the emulsified liquid obtained in the step (4) into a mould after ultrasonic defoaming, standing for 48 hours at normal temperature, and finally freeze-drying to prepare the collagen peptide wound dressing.
In a further improvement, the temperature is raised in the mixing process in the step 3, and the temperature of the temperature rise is as follows: 85 ℃.
In a further improvement, the emulsification temperature in the step 4 is as follows: 80 ℃.
Compared with the prior art, the invention has the following beneficial effects:
the collagen peptide wound dressing is mainly prepared from collagen and lactoferrin, and has the advantages of simple process and low preparation cost; the polyvinylpyrrolidone, the pseudo-ginseng and the Japanese thistle can achieve the effects of detoxifying, stopping bleeding, improving the dissolution concentration, preventing peritoneal adhesions, promoting blood sedimentation and the like. The oat gum has the main components of beta-glucan, has the effects of reducing blood fat and serum cholesterol, has important effects of preventing and treating cardiovascular and cerebrovascular diseases and diabetes, has super-strong oxidation resistance which is 50 times of vitamin E and 20 times of vitamin C, can delay aging and prevent arteriosclerosis, is added with various vitamins to ensure nutrition and absorption, has good corrosion resistance due to the addition of a small amount of honey, and can organize bacterial infection.
Example 2
The invention provides a collagen peptide wound dressing and a preparation method thereof, wherein the collagen peptide wound dressing comprises the following raw materials, by weight, 30% of collagen, 12% of lactoferrin, 10% of bone glue, 11% of polyvinylpyrrolidone, 10% of oat glue, 6% of anthocyanin, 4% of wolfberry, 4% of pseudo-ginseng, 5% of Japanese thistle herb, 3% of honey, 1% of vitamin and 4% of corn starch.
In a further improvement, the collagen is an extract of animal bones such as fish skin or fish scales, yak bones and the like.
In a further improvement, the vitamin is a combination of vitamin A, vitamin B, vitamin D and vitamin E.
In a further improvement, the honey is all-flower honey, longan honey, rape flower honey, loquat honey, orange honey, lychee honey, sophora flower honey, chastetree fruit honey, jujube flower honey and the like.
Wherein the common northern part is one or more of Chinese date honey, sophora flower honey, wattle honey and all-flower honey.
The preparation method comprises the following steps:
step 1: selecting animal bones as raw materials, adding purified water, steaming to obtain a treated material, cooling the treated material to 56 ℃, adding lipase, stirring for enzymolysis for 30min, then adding chymotrypsin and ficin, stirring for enzymolysis for 3.5h, and inactivating enzyme after the enzymolysis is finished to obtain an enzymolysis liquid; separating, purifying and drying the enzymolysis liquid to obtain collagen peptide;
step 2: decocting fructus Lycii, Notoginseng radix and herba seu radix Cirsii Japonici in water for 1.5 hr to obtain medicinal liquid, sieving to remove impurities, and distilling to obtain pure medicinal liquid;
step 3, adding lactoferrin into the collagen peptide obtained in the step 1, putting the collagen peptide into a mixer, stirring and mixing, heating in the mixing process, fully mixing, adding bone glue, polyvinylpyrrolidone, oat glue, anthocyanin, honey, vitamins and corn starch, and fully stirring to form paste sticky matter;
and 4, step 4: adding the liquid medicine and vitamins obtained in the step 2 into the paste-like sticky matter obtained in the step 3, fully mixing, putting into an emulsifying machine for emulsifying at a certain temperature, and homogenizing the emulsified slurry by a high-pressure homogenizer to obtain an emulsified liquid;
and 5: and (4) introducing the emulsified liquid obtained in the step (4) into a mould after ultrasonic defoaming, standing for 36 hours at the normal temperature, and finally freeze-drying to prepare the collagen peptide wound dressing.
In a further improvement, the temperature is raised in the mixing process in the step 3, and the temperature of the temperature rise is as follows: 80 ℃.
In a further improvement, the emulsification temperature in step 4 is as follows: at 75 ℃.
Compared with the prior art, the invention has the following beneficial effects:
the collagen peptide wound dressing is mainly prepared from collagen and lactoferrin, and has the advantages of simple process and low preparation cost; the polyvinylpyrrolidone, the pseudo-ginseng and the Japanese thistle can achieve the effects of detoxifying, stopping bleeding, improving the dissolution concentration, preventing peritoneal adhesions, promoting blood sedimentation and the like. The oat gum has the main components of beta-glucan, has the effects of reducing blood fat and serum cholesterol, has important effects of preventing and treating cardiovascular and cerebrovascular diseases and diabetes, has super-strong oxidation resistance which is 50 times of vitamin E and 20 times of vitamin C, can delay aging and prevent arteriosclerosis, is added with various vitamins to ensure nutrition and absorption, has good corrosion resistance due to the addition of a small amount of honey, and can organize bacterial infection.
Example 3
The invention provides a collagen peptide wound dressing and a preparation method thereof, wherein the collagen peptide wound dressing comprises the following raw materials, by weight, 35% of collagen, 10% of lactoferrin, 8% of bone glue, 8% of polyvinylpyrrolidone, 8% of oat glue, 5% of anthocyanin, 3% of medlar, 3% of pseudo-ginseng, 4% of Cirsium setosum, 2% of honey, 1% of vitamin and 3% of corn starch.
In a further improvement, the collagen is an extract of animal bones such as fish skin or fish scales, yak bones and the like.
In a further improvement, the vitamin is a combination of vitamin A, vitamin B, vitamin D and vitamin E.
In a further improvement, the honey is all-flower honey, longan honey, rape flower honey, loquat honey, orange honey, lychee honey, sophora flower honey, chastetree fruit honey, jujube flower honey and the like. Wherein the common northern part is one or more of Chinese date honey, sophora flower honey, wattle honey and all-flower honey.
The preparation method comprises the following steps:
step 1: selecting yak bones as a raw material, adding purified water, cooking to obtain a treated material, cooling the treated material to 55 ℃, adding lipase, stirring for enzymolysis for 20min, then adding chymotrypsin and ficin, stirring for enzymolysis for 3h, and inactivating enzyme after the enzymolysis is finished to obtain an enzymolysis liquid; separating, purifying and drying the enzymolysis liquid to obtain collagen peptide;
step 2: decocting fructus Lycii, Notoginseng radix and herba seu radix Cirsii Japonici in water for 1 hr to obtain medicinal liquid, sieving to remove impurities, and distilling to obtain pure medicinal liquid;
step 3, adding lactoferrin into the collagen peptide obtained in the step 1, putting the collagen peptide into a mixer, stirring and mixing, heating in the mixing process, fully mixing, adding bone glue, polyvinylpyrrolidone, oat glue, anthocyanin, honey, vitamins and corn starch, and fully stirring to form paste sticky matter;
and 4, step 4: adding the liquid medicine and vitamins obtained in the step 2 into the paste-like sticky matter obtained in the step 3, fully mixing, putting into an emulsifying machine for emulsifying at a certain temperature, and homogenizing the emulsified slurry by a high-pressure homogenizer to obtain an emulsified liquid;
and 5: and (4) introducing the emulsified liquid obtained in the step (4) into a mould after ultrasonic defoaming, standing for 24 hours at normal temperature, and finally freeze-drying to prepare the collagen peptide wound dressing.
In a further improvement, the temperature is raised in the mixing process in the step 3, and the temperature of the temperature rise is as follows: at 75 ℃.
In a further improvement, the emulsification temperature in step 4 is as follows: at 70 ℃.
Compared with the prior art, the invention has the following beneficial effects:
the collagen peptide wound dressing is mainly prepared from collagen and lactoferrin, and has the advantages of simple process and low preparation cost; the polyvinylpyrrolidone, the pseudo-ginseng and the Japanese thistle can achieve the effects of detoxifying, stopping bleeding, improving the dissolution concentration, preventing peritoneal adhesions, promoting blood sedimentation and the like. The oat gum has the main components of beta-glucan, has the effects of reducing blood fat and serum cholesterol, has important effects of preventing and treating cardiovascular and cerebrovascular diseases and diabetes, has super-strong oxidation resistance which is 50 times of vitamin E and 20 times of vitamin C, can delay aging and prevent arteriosclerosis, is added with various vitamins to ensure nutrition and absorption, has good corrosion resistance due to the addition of a small amount of honey, and can organize bacterial infection.
Comparative example 4
A collagen peptide wound dressing and a preparation method thereof comprise the following raw materials, by weight, 25% -35% of collagen, 10% -15% of lactoferrin, 8% -12% of bone glue, 8% -12% of oat glue, 5% -8% of anthocyanin and 3% -5% of medlar.
The improved food comprises 50% of collagen, 20% of lactoferrin, 10% of bone glue, 10% of oat glue, 6% of anthocyanin, 4% of medlar and the like according to the weight percentage.
The preparation method comprises the following steps:
step 1: selecting poultry bones as raw materials, adding purified water, cooking to obtain a treated material, cooling the treated material to 55-57 ℃, adding lipase, stirring and performing enzymolysis for 20-40 min, then adding chymotrypsin and ficin, stirring and performing enzymolysis for 3-4 h, and inactivating enzymes after the enzymolysis is finished to obtain an enzymolysis liquid; separating, purifying and drying the enzymolysis liquid to obtain collagen peptide;
step 2, adding lactoferrin into the collagen peptide obtained in the step 1, putting the collagen peptide into a mixer, stirring and mixing, heating in the mixing process, fully mixing, adding bone glue, oat glue and anthocyanin, and fully stirring to form paste sticky matter;
and step 3: putting the paste-like sticky substance obtained in the step 2 into an emulsifying machine for emulsifying at a certain temperature, and homogenizing the emulsified slurry by a high-pressure homogenizer to obtain an emulsified liquid;
and 4, step 4: and (3) introducing the emulsion obtained in the step (3) into a mould after ultrasonic defoaming, standing for 24-48 h at normal temperature, and finally freeze-drying to obtain the collagen peptide wound dressing.
The use effect is as follows: the collagen peptide wound dressing is mainly prepared from collagen and lactoferrin, and has simple process and low preparation cost; the main component of the oat gum is beta-glucan which has the functions of reducing blood fat and serum cholesterol and has important effects of preventing and treating cardiovascular and cerebrovascular diseases and diabetes, and the procyanidine has super-strong oxidation resistance which is 50 times of vitamin E and 20 times of vitamin C, and can delay aging and prevent arteriosclerosis.
And (3) testing the nutrient components: the results of the recovery test using the collagen peptide dressings prepared in examples 1, 2, 3 and comparative example 4 are shown in table 1:
| sample (I) | Relative recovery area (%) | Recovery time (sky) |
| Example 1 | 94 | 3 |
| Example 2 | 92 | 4 |
| Example 3 | 96 | 5 |
| Comparative example 4 | 72 | 8 |
TABLE 1
As can be seen from table 1, the collagen peptide wound dressings provided in examples 1, 2 and 3 of the present invention have a higher recovery effect than that of comparative example 4, and the recovery time is greatly shortened as compared to comparative example 4.
And (3) detecting the preparation amount of the collagen peptide: 1kg of different raw materials were used to prepare collagen peptides, and the weight components of the collagen peptides prepared in examples 1, 2 and 3 and the collagen peptide prepared in comparative example 4 were measured; the results are shown in Table 2:
TABLE 2
It can be seen from table 2 that the collagen peptides obtained in examples 1, 2 and 3 were relatively high in content, and the collagen peptides obtained in comparative example 4 were relatively low in content.
Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that changes may be made in the embodiments and/or equivalents thereof without departing from the spirit and scope of the invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (8)
1. A collagen peptide wound dressing, characterized in that: the collagen protein milk powder comprises, by weight, 25-35% of collagen, 10-15% of lactoferrin, 8-12% of bone glue, 8-14% of polyvinylpyrrolidone, 8-12% of oat glue, 5-8% of anthocyanin, 3-5% of medlar, 3-5% of pseudo-ginseng, 4-6% of Japanese thistle herb, 2-4% of honey, 1-2% of vitamin and 3-5% of corn starch.
2. The collagen peptide wound dressing of claim 1, wherein: the collagen protein-containing sea cucumber nutritional oral liquid comprises, by weight, 30% of collagen, 12% of lactoferrin, 10% of bone glue, 11% of polyvinylpyrrolidone, 10% of oat glue, 6% of anthocyanin, 4% of medlar, 4% of pseudo-ginseng, 5% of Japanese thistle herb, 3% of honey, 1% of vitamin and 4% of corn starch.
3. The collagen peptide wound dressing of claim 2, wherein: the collagen is extract of animal bone such as fish skin or fish scale, bone of yak, etc.
4. The collagen peptide wound dressing of claim 2, wherein: the vitamins are a composition of vitamin A, vitamin B, vitamin D and vitamin E.
5. The collagen peptide wound dressing of claim 2, wherein: the honey is selected from honey of various flowers, longan honey, rape flower honey, loquat honey, orange honey, lychee honey, sophora flower honey, chastetree honey, date honey, etc.; wherein the common northern part is one or more of Chinese date honey, sophora flower honey, wattle honey and all-flower honey.
6. The method of preparing a collagen peptide wound dressing according to claim 1, wherein: the preparation method comprises the following steps:
step 1: selecting fish scales or fish skins or other animal bones as raw materials, adding purified water, steaming to obtain a treated material, cooling the treated material to 55-57 ℃, adding lipase, stirring for enzymolysis for 20-40 min, then adding chymotrypsin and ficin, stirring for enzymolysis for 3-4 h, and inactivating enzymes after enzymolysis is finished to obtain an enzymolysis liquid; separating, purifying and drying the enzymolysis liquid to obtain collagen peptide;
step 2: decocting the medlar, the pseudo-ginseng and the Japanese thistle in water respectively for 1-2 h, sieving the obtained liquid medicine to remove impurities, and obtaining pure liquid medicine in a distillation mode;
step 3, adding lactoferrin into the collagen peptide obtained in the step 1, putting the collagen peptide into a mixer, stirring and mixing, heating in the mixing process, fully mixing, adding bone glue, polyvinylpyrrolidone, oat glue, anthocyanin, honey, vitamins and corn starch, and fully stirring to form paste sticky matter;
and 4, step 4: adding the liquid medicine and vitamins obtained in the step 2 into the paste-like sticky matter obtained in the step 3, fully mixing, putting into an emulsifying machine for emulsifying at a certain temperature, and homogenizing the emulsified slurry by a high-pressure homogenizer to obtain an emulsified liquid;
and 5: and (4) introducing the emulsion obtained in the step (4) into a mould after ultrasonic defoaming, standing for 24-48 h at normal temperature, and finally freeze-drying to obtain the collagen peptide wound dressing.
7. The method of preparing a collagen peptide wound dressing according to claim 6, wherein: and (3) heating in the mixing process in the step (3), wherein the heating temperature is as follows: 75-85 ℃.
8. The method of preparing a collagen peptide wound dressing according to claim 6, wherein: the emulsification temperature in the step 4 is as follows: 70-80 ℃.
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| CN116421775A (en) * | 2023-04-21 | 2023-07-14 | 青岛优瑞达生物科技有限公司 | Lactoferrin gel dressing, preparation method and application |
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| CN105661538A (en) * | 2016-01-09 | 2016-06-15 | 深圳爱易瑞科技有限公司 | Collagen peptide powder and preparation method thereof |
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