CN115381733A - Anti-aging composition for promoting collagen effect and application thereof - Google Patents
Anti-aging composition for promoting collagen effect and application thereof Download PDFInfo
- Publication number
- CN115381733A CN115381733A CN202211169162.9A CN202211169162A CN115381733A CN 115381733 A CN115381733 A CN 115381733A CN 202211169162 A CN202211169162 A CN 202211169162A CN 115381733 A CN115381733 A CN 115381733A
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- CN
- China
- Prior art keywords
- collagen
- parts
- zinc
- chitosan
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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Classifications
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Abstract
The invention discloses an anti-aging composition for promoting collagen effect and application thereof. The composition comprises collagen, chitosan and zinc, wherein the chitosan is low-molecular-weight chitosan, the chitosan and the zinc can promote the absorption and synthesis of the collagen, and the chitosan and the zinc are added into the composition consisting of the collagen, so that the composition not only can keep respective efficacy and functions, but also can play a role in synergy, and can promote the absorption and synthesis efficiency of the collagen to improve the skin moisturizing function, increase the skin elasticity of a human body and reduce the skin wrinkle depth, and has the function of resisting aging. And by adjusting the dosage proportion of the collagen, the chitosan and the zinc, the synergistic interaction can be realized.
Description
Technical Field
The invention relates to the technical field of food, cosmetics and medicines, in particular to an anti-aging composition for promoting collagen function and application thereof.
Background
Skin is the largest organ of the human body and suffers from aging as well as other organs of the human body. Skin aging is classified into exogenous and endogenous causes. Environmental pollution, bad living habits such as alcoholism and smoking and ultraviolet irradiation in sunlight are exogenous factors, and endogenous factors of skin aging are mainly caused by that the normal physiological circulation balance of the skin is broken due to the fact that the cell activity of a human body is reduced, the cell metabolism is slowed down, the repairing capability is poor and the immunity is reduced along with the increase of the age of the human body, collagen in the skin is continuously reduced, moisturizing factors are continuously lost, skin pigments are increased, and the capacities of resisting oxidation and removing free radicals of the skin are reduced. The aging factors of the skin can lead the skin to lose softness, elasticity and luster, and lead the skin to have a series of aging phenomena such as wrinkles and the like.
Collagen is a biological macromolecule, is a main component in the connective tissue of animals, is also a functional protein with the largest content and the widest distribution in mammals, accounts for 25 to 30 percent of the total amount of protein, and has good biocompatibility, biodegradability and bioactivity, so the collagen is widely applied to the fields of food, medicine, tissue engineering, cosmetics and the like. For example, collagen is extracted from animal skin, the skin contains proteoglycan such as hyaluronic acid and chondroitin sulfate besides collagen, and the proteoglycan contains a large amount of polar groups, is a moisturizing factor and has the effect of preventing tyrosine in the skin from being converted into melanin, so the collagen has the effects of purely natural moisturizing, whitening, crease resistance, freckle removal and the like, and can be widely applied to beauty products. The chemical composition and structure of collagen make it the basis of beauty. The collagen is similar to the structure of human skin collagen, is water insoluble fibrous glycoprotein, contains abundant amino acids and hydrophilic groups in molecules, has certain surface activity and good compatibility, and has good moisturizing effect because the molecules contain abundant hydroxyl groups. At a relative humidity of 70%, it can still retain 45% of its own weight of moisture. The test proves that: a pure solution of 0.01% collagen forms a very good water-retaining layer, supplying all the water needed by the skin. Locking water, storing water, repairing fractured and aged elastic fiber nets, reforming skin tissue structures and unfolding wrinkles; in addition, the skin care product can also clear free radicals in vivo, resist oxidation and slow down skin aging: smooth fine lines and eliminate red blood streak. After entering the dermis, the collagen can rapidly fill collapsed tissues, tighten the skin, enhance the elasticity, smooth fine wrinkles, keep the body young, prevent aging and greatly help beauty and health.
Chitosan is a primary derivative of chitin. The chemical structure of the fiber is a macromolecular alkaline polysaccharide polymer with cations, and the polysaccharide polymer is the only edible fiber with positive charges and cations in the nature; has the physical and chemical properties of stable physical properties, good solubility, hydrophilic hygroscopicity, biodegradability, biocompatibility, film-forming property, cohesiveness, air permeability and the like. Particularly, because of the pure natural activity and no toxic or side effect of the chitosan, the chitosan has good affinity to human bodies, can promote the organisms to synthesize and secrete a large amount of immunoglobulin antibodies, and can regulate and improve the immunity of the human bodies; adsorbate endotoxins, harmful pigments, and radiatins; chelating harmful heavy metal ions in vivo, such as lead, mercury and cadmium, and discharging out of the body along with metabolites; regulating pH value of human body, enhancing quality and quantity of immunocompetent cells, and activating normal somatic cells; promoting secretion of male and female hormone; inhibiting the formation of lipid peroxide and delaying aging; inhibiting cancer cell metastasis; strengthening liver function, regulating blood fat, blood sugar and blood pressure, so that it can be extensively used in health-care food and medicine additive. The sixth life element which is put together with five nutrient elements of protein, fat, sugar, vitamin and mineral substance necessary for human life is reputed by medical experts in Europe, america, china, japan, russia and other countries.
Zinc is one of essential trace elements for human body, plays an extremely important role in the growth and development process of human body, is usually praised as 'flowers of life' and 'sources of intelligence', is used for supplementing zinc, namely supplementing the essential trace elements for human body, and plays an extremely important role in growth and development, immunity, vitamins and the like of human body. Zinc is present in a number of enzyme systems, such as carbonic anhydrase, respiratory enzyme, lactate dehydrogenase, superoxide dismutase, alkaline phosphatase, DNA and RNA polymerase, and the like, and is an essential substance for the synthesis of nucleic acids, proteins, carbohydrates and vitamin A utilization. Has effects in promoting growth and development, and improving taste. Zinc is an essential component for regulating DNA replication and nucleic acid metabolism, is closely related to protein synthesis, participates in growth hormone synthesis, and has important promotion effect on organism growth and development.
The three substances are commonly applied in a few examples, and most of the applications only use the respective properties of the three substances, and do not show the synergistic effect of the collagen, the chitosan and the zinc to enhance the absorption and synthesis efficiency of the collagen to improve the skin moisturizing function, increase the skin elasticity of a human body and relieve the anti-aging effect of the skin wrinkle depth in the fields of food, cosmetics or medicines.
Disclosure of Invention
In order to solve the problems, the invention provides an anti-aging composition for promoting collagen effects, which takes chitosan and zinc as promoters, enhances the absorption and synthesis efficiency of collagen to improve the skin moisturizing function, increases the skin elasticity of a human body and relieves the skin wrinkle depth, and can also play a synergistic effect and an interaction role by adjusting the dosage proportion of the collagen, the chitosan and the zinc.
The specific technical scheme of the invention is as follows:
1. a composition comprising collagen, chitosan, and zinc.
2. The composition of claim 1, wherein the collagen is selected from the group consisting of: type I collagen, type II collagen, type III collagen, type V collagen, type XI collagen, oligopeptide, recombinant humanized collagen, preferably type I collagen.
3. Composition according to claim 1, wherein the collagen has a molecular weight of 200 to 10000Da, preferably 300 to 5000Da, more preferably 800 to 3000Da.
4. The composition according to claim 1, wherein the chitosan is a low molecular weight chitosan having a molecular weight of 200-20000 Da, preferably 300-5000 Da, more preferably 800-3200 Da.
5. The composition of claim 1, wherein the zinc is selected from the group consisting of: zinc sulfate, zinc gluconate, zinc glycinate, zinc oxide, zinc lactate, zinc citrate, zinc chloride, zinc acetate and zinc carbonate, preferably zinc citrate.
6. The composition according to any one of claims 1 to 5, wherein the collagen is present in an amount of 1000 to 100000 parts, preferably 10000 to 100000 parts, and more preferably 50000 to 100000 parts; 10-10000 parts of chitosan, preferably 500-10000 parts of chitosan, and further preferably 2500-10000 parts of chitosan; the amount of the zinc is 0.1 to 100 parts, preferably 1 to 100 parts, and more preferably 5 to 100 parts.
7. An article of manufacture which is a food, cosmetic or pharmaceutical product, preferably a food product which is a health food.
8. The composition according to any one of claims 1 to 7, wherein the composition is contained in an amount of 30% by mass or more in the product.
9. The product of claim 7, further comprising an adjuvant, wherein the adjuvant is a food, cosmetic or pharmaceutical acceptable adjuvant.
10. The composition according to any one of claims 1 to 9 has application in the field of food, cosmetics or pharmaceuticals, preferably the food is a health food.
ADVANTAGEOUS EFFECTS OF INVENTION
The composition provided by the invention comprises collagen, chitosan and zinc, wherein the collagen, the chitosan and the zinc can interact, the chitosan and the zinc can promote the absorption and synthesis of the collagen, and the chitosan and the zinc are added into the composition consisting of the collagen, so that the composition not only can keep respective efficacy and function, but also can play a role in synergy, and can promote the absorption and synthesis efficiency of the collagen to improve the skin moisturizing function, increase the skin elasticity and relieve the skin wrinkle depth, and is applied to anti-aging in the fields of food, cosmetics or medicine.
Detailed Description
The present invention will be described in detail below. While specific embodiments of the invention have been shown, it should be understood that the invention may be embodied in various forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the invention to those skilled in the art. It should be noted that certain terms are used throughout the description and claims to refer to particular components. As one skilled in the art will appreciate, various names may be used to refer to a component. This specification and claims do not intend to distinguish between components that differ in name but not function. In the following description and in the claims, the terms "include" and "comprise" are used in an open-ended fashion, and thus should be interpreted to mean "include, but not limited to. The description is made for the purpose of illustrating the general principles of the specification and is not to be taken in a limiting sense.
The present invention provides a composition comprising collagen, chitosan and zinc.
In a preferred embodiment of the present invention, wherein the collagen is selected from the group consisting of: collagen type I, collagen type II, collagen type III, collagen type V, collagen type XI, oligopeptide, recombinant humanized collagen, preferably collagen type I.
The type I collagen consists of three peptide chains, two alpha (I) chains and one alpha (II) chain. Has the strongest effect on the body functions.
The type II collagen is a naturally occurring protein, and is present in hyaline cartilage and articular cartilage of the human body.
The type III collagen is the main collagen in human skin, fascia and tendon, is homotrimer, or is protein composed of three identical peptide chains (monomers).
The peptide chain of the type V collagen consists of 2 α 1 chains and 1 α 2 chains or 3 α 1 chains, in 3 assembly forms. The type V collagen is distributed around cells and type I collagen, and may act as a bridge between the basement membrane and connective tissue.
The type XI collagen is heterotrimer, and its composition is α 1 (XI) α 2 (XI) α 3 (XI), and type VI collagen is a minor component of cartilage, plays an important role in the formation of cartilage collagen fiber and the composition of cartilage matrix, and often coexists with type II collagen.
The oligopeptide refers to collagen obtained by hydrolysis or enzymolysis, has a molecular weight generally below 1000 daltons, and is also called small peptide, oligopeptide or small molecule active peptide.
The recombinant humanized collagen is based on the original gene sequence of human skin type III collagen, the parts with strong water solubility and high biological activity are optimized and selected to carry out codon optimization and splicing recombination, so that a brand new recombinant humanized type III collagen sequence is obtained, the large-scale production can be realized by utilizing a biological fermentation technology, and experiments prove that the collagen has large expression quantity, good water solubility and high biological activity, and the performance of the collagen is superior to that of human natural collagen.
In a preferred embodiment of the present invention, wherein, the collagen is 1000 to 100000 parts by weight, preferably 10000 to 100000 parts by weight, and more preferably 50000 to 100000 parts by weight; the chitosan is 10 to 10000 parts, preferably 500 to 10000 parts, and further preferably 2500 to 10000 parts; the amount of zinc is 0.1 to 100 parts, preferably 1 to 100 parts, and more preferably 5 to 100 parts. For example, the collagen may be 1000 parts, 1500 parts, 2000 parts, 2500 parts, 3000 parts, 3500 parts, 4000 parts, 4500 parts, 5000 parts, 5500 parts, 6000 parts, 6500 parts, 7000 parts, 7500 parts, 8000 parts, 8500 parts, 9000 parts, 9500 parts, 10000 parts, 15000 parts, 20000 parts, 25000 parts, 30000 parts, 35000 parts, 40000 parts, 45000 parts, 50000 parts, 55000 parts, 60000 parts, 65000 parts, 70000 parts, 75000 parts, 80000 parts, 85000 parts, 90000 parts, 95000 parts, etc., in parts by weight, or any range between any of these parts; the chitosan may be 10 parts, 50 parts, 100 parts, 150 parts, 200 parts, 250 parts, 300 parts, 350 parts, 400 parts, 450 parts, 500 parts, 550 parts, 600 parts, 650 parts, 700 parts, 750 parts, 800 parts, 850 parts, 900 parts, 950 parts, 1000 parts, 2000 parts, 3000 parts, 4000 parts, 5000 parts, 6000 parts, 7000 parts, 8000 parts, 9000 parts, 10000 parts, etc., or any range between any of these parts; the zinc can be 0.1 parts, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 15 parts, 20 parts, 25 parts, 30 parts, 35 parts, 40 parts, 45 parts, 50 parts, 55 parts, 60 parts, 65 parts, 70 parts, 75 parts, 80 parts, 85 parts, 90 parts, 95 parts, etc., or any range between any of these parts.
When 1000 to 100000 parts of collagen, preferably 10000 to 100000 parts, and more preferably 50000 to 100000 parts is used for the composition; adding 10-10000 parts of chitosan, preferably 500-10000 parts, and more preferably 2500-10000 parts; the zinc is added in an amount of 0.1 to 100 parts, preferably 1 to 100 parts, and more preferably 5 to 100 parts.
In a preferred embodiment of the present invention, wherein the collagen has a molecular weight of 200 to 10000Da, preferably 300 to 5000Da, and more preferably 800 to 3000Da. For example, the collagen molecular weight may be 200Da, 300Da, 400Da, 500Da, 600Da, 700Da, 800Da, 1000Da, 1500Da, 2000Da, 2500Da, 3000Da, 3500Da, 4000Da, 4500Da, 5000Da, 6000Da, 7000Da, 8000Da, 9000Da, 10000Da, and the like.
In a preferred embodiment of the present invention, the molecular weight of the chitosan is 200-20000 Da, preferably 300-5000 Da, more preferably 800-3200 Da. For example, the chitosan molecular weight may be 200Da, 300Da, 400Da, 500Da, 600Da, 700Da, 800Da, 1000Da, 1500Da, 2000Da, 2500Da, 3000Da, 3500Da, 4000Da, 4500Da, 5000Da, 6000Da, 7000Da, 8000Da, 9000Da, 10000Da, 15000Da, 20000Da, and the like.
The molecular weight of the collagen and chitosan refers to a weight average molecular weight.
The invention provides a product, which comprises the composition, wherein the composition contains more than 30% of the composition in percentage by mass in the product.
In a preferred embodiment of the present invention, the product is a food, a cosmetic or a pharmaceutical product.
In a preferred embodiment of the present invention, the product further comprises an auxiliary material, and the auxiliary material is a food, cosmetic or pharmaceutical acceptable auxiliary material. The auxiliary material is not limited in any way, and may be determined as needed, for example, the auxiliary material may be fruit powder, mineral, vitamin, phospholipid, hyaluronic acid or salt thereof, sweetener, vegetable edible oil, edible colorant, stabilizer, thickener, emulsifier, preservative, etc.
The invention provides an anti-aging application of the composition in the fields of food, cosmetics or medicines.
The composition of the invention: the chitosan and the zinc are added into the composition consisting of the collagen, so that the synergistic interaction effect can be realized while the respective effects are maintained, the absorption and synthesis efficiency of the collagen can be promoted to improve the skin moisturizing function, the skin elasticity of a human body is improved, and the anti-aging effect of the skin wrinkle depth is reduced in the fields of food, cosmetics or medicines.
Examples
The following examples are intended to illustrate the invention but are not intended to limit the scope of the invention. The practice is not to be taken in a manner consistent with the techniques or conditions described in the literature or the product specification, unless otherwise indicated. The reagents or instruments used are not indicated by manufacturers, and are conventional products available from regular distributors, wherein collagen, chitosan, and zinc are provided by natural products, ltd, shanxi french.
Example 1
The embodiment 1 is an anti-aging composition for promoting collagen function, which comprises the following components in parts by weight: 10000 parts of collagen, 500 parts of chitosan and 1 part of zinc.
The composition for promoting collagen effect can be made into tablet, capsule, granule, powder, pill, beverage, oral liquid, etc. by conventional method in the art.
Example 2
The embodiment 2 is an anti-aging composition for promoting collagen function, which comprises the following components in parts by weight: 50000 parts of collagen, 3000 parts of chitosan and 8 parts of zinc.
The composition for promoting collagen effect can be made into tablet, capsule, granule, powder, pill, beverage, oral liquid, etc. by conventional method in the art.
Example 3
This example 3 is a commercial collagen powder of the same type.
The preparation of the compositions described in examples 1-2 specifically comprises: weighing the raw materials according to the proportion, mixing the raw materials, stirring the mixture for 30 to 60 minutes at the speed of 5 to 7r/min, sieving the mixture by a sieve of 30 to 100 meshes, filling the mixture, and entering a qualified product area of a storehouse after the finished product is inspected to be qualified.
Test example 1
When the anti-aging composition for promoting collagen effect prepared in examples 1-2 is taken with the same type of product available in the market, example 3 (collagen powder), the skin moisture retention rate effect is tested by a skin tester.
Selecting 9 volunteer women, wherein the average age is 50 years old and the skin is similar; every 3 people take the same collagen powder 5 g each time, and take the collagen powder in the morning and at night every day for three months continuously.
The skin hydration moisture retention test is shown in the following table:
as can be seen from the above table, after three months of administration, the anti-aging composition for promoting collagen function described in examples 1-2 has an obvious moisturizing function, and the effect is superior to that of similar products on the market.
Test example 2
When the anti-aging composition for promoting collagen effect prepared in examples 1-2 is taken together with the similar product in the market, i.e., collagen powder, the skin elasticity increasing rate effect is tested by a skin elasticity tester.
Selecting 9 volunteer women, wherein the average age is 50 years old and the skin is similar; every 3 persons take the same collagen powder 5 g each time, once every morning and evening, and continuously for three months.
The skin elasticity increase rate was measured as shown in the following table:
as can be seen from the above table, after three months of administration, the collagen-promoting anti-aging composition described in examples 1-2 has an obvious effect of increasing skin elasticity, and the effect is superior to that of the similar products on the market.
Test example 3
When the anti-aging composition for promoting collagen effect prepared in examples 1-2 is taken with the similar product in the market, namely collagen powder in example 3, the effect of the wrinkle depth rate is tested by a skin wrinkle tester and compared.
Selecting 9 volunteer women, wherein the average age is 50 years old and the skin is similar; every 3 persons take the same collagen powder 5 g each time, once every morning and evening, and continuously for three months.
Skin wrinkle depth rate measurements are shown in the following table:
as can be seen from the above table, after three months of administration, the collagen-promoting anti-aging composition described in examples 1-2 has an obvious skin wrinkle depth reduction effect, and the effect is superior to that of the similar products on the market.
In conclusion, the composition disclosed by the invention takes chitosan and zinc as the promoters, can keep respective effects and play a role in synergy, can promote the absorption and synthesis efficiency of collagen to improve the skin moisturizing function, increase the skin elasticity of a human body and relieve the skin wrinkle depth, and has the anti-aging effect.
Although the invention has been described in detail hereinabove by way of general illustration and by way of specific embodiments and tests, it will be apparent to those skilled in the art that modifications and improvements can be made thereto. Therefore, it is intended that all such modifications and improvements be made without departing from the spirit of the invention.
Claims (10)
1. A composition comprising collagen, chitosan, and zinc.
2. The composition of claim 1, wherein the collagen is selected from the group consisting of: type I collagen, type II collagen, type III collagen, type V collagen, type XI collagen, oligopeptide, recombinant humanized collagen, preferably type I collagen.
3. Composition according to claim 1, wherein the collagen has a molecular weight of 200 to 10000Da, preferably 300 to 5000Da, more preferably 800 to 3000Da.
4. The composition according to claim 1, wherein the chitosan is a low molecular weight chitosan having a molecular weight of 200-20000 Da, preferably 300-5000 Da, more preferably 800-3200 Da.
5. The composition of claim 1, wherein the zinc is selected from the group consisting of: zinc sulfate, zinc gluconate, zinc glycinate, zinc oxide, zinc lactate, zinc citrate, zinc chloride, zinc acetate and zinc carbonate, preferably zinc citrate.
6. The composition according to any one of claims 1 to 5, wherein the collagen is present in an amount of 1000 to 100000 parts, preferably 10000 to 100000 parts, and more preferably 50000 to 100000 parts; the chitosan accounts for 10 to 10000 parts, preferably 500 to 10000 parts, and further preferably 2500 to 10000 parts; the amount of zinc is 0.1 to 100 parts, preferably 1 to 100 parts, and more preferably 5 to 100 parts.
7. An article of manufacture which is a food, cosmetic or pharmaceutical product, preferably a food product which is a health food.
8. The composition according to any one of claims 1 to 7, wherein the composition is contained in an amount of 30% by mass or more in the product.
9. The product of claim 7, further comprising an adjuvant, wherein the adjuvant is a food, cosmetic, or pharmaceutical acceptable adjuvant.
10. The composition according to any one of claims 1 to 9 has application in the field of food, cosmetics or pharmaceuticals, preferably the food is a health food.
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