CN112471351A - Composition for preventing livestock and poultry diarrhea and preparation method thereof - Google Patents
Composition for preventing livestock and poultry diarrhea and preparation method thereof Download PDFInfo
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- CN112471351A CN112471351A CN202011272054.5A CN202011272054A CN112471351A CN 112471351 A CN112471351 A CN 112471351A CN 202011272054 A CN202011272054 A CN 202011272054A CN 112471351 A CN112471351 A CN 112471351A
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- 206010012735 Diarrhoea Diseases 0.000 title claims abstract description 70
- 244000144972 livestock Species 0.000 title claims abstract description 55
- 244000144977 poultry Species 0.000 title claims abstract description 51
- 239000000203 mixture Substances 0.000 title claims abstract description 40
- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- 239000000284 extract Substances 0.000 claims abstract description 87
- 241000219000 Populus Species 0.000 claims abstract description 37
- 229910052500 inorganic mineral Inorganic materials 0.000 claims abstract description 28
- 150000002500 ions Chemical class 0.000 claims abstract description 28
- 239000011707 mineral Substances 0.000 claims abstract description 28
- 244000063299 Bacillus subtilis Species 0.000 claims abstract description 27
- 235000014469 Bacillus subtilis Nutrition 0.000 claims abstract description 27
- PUKLDDOGISCFCP-JSQCKWNTSA-N 21-Deoxycortisone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)C)(O)[C@@]1(C)CC2=O PUKLDDOGISCFCP-JSQCKWNTSA-N 0.000 claims abstract description 24
- FCYKAQOGGFGCMD-UHFFFAOYSA-N Fulvic acid Natural products O1C2=CC(O)=C(O)C(C(O)=O)=C2C(=O)C2=C1CC(C)(O)OC2 FCYKAQOGGFGCMD-UHFFFAOYSA-N 0.000 claims abstract description 24
- 229940095100 fulvic acid Drugs 0.000 claims abstract description 24
- 239000002509 fulvic acid Substances 0.000 claims abstract description 24
- 239000008213 purified water Substances 0.000 claims abstract description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 23
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims abstract description 19
- 235000019206 astragalus extract Nutrition 0.000 claims abstract description 14
- 235000010755 mineral Nutrition 0.000 claims description 27
- 238000001914 filtration Methods 0.000 claims description 25
- 239000009636 Huang Qi Substances 0.000 claims description 18
- 244000197580 Poria cocos Species 0.000 claims description 18
- 235000008599 Poria cocos Nutrition 0.000 claims description 18
- 238000002791 soaking Methods 0.000 claims description 15
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 10
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 10
- 239000012535 impurity Substances 0.000 claims description 10
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 7
- 241000045403 Astragalus propinquus Species 0.000 claims description 5
- 229910000503 Na-aluminosilicate Inorganic materials 0.000 claims description 5
- 241000218998 Salicaceae Species 0.000 claims description 5
- 235000006533 astragalus Nutrition 0.000 claims description 5
- 229910021538 borax Inorganic materials 0.000 claims description 5
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 5
- UQGFMSUEHSUPRD-UHFFFAOYSA-N disodium;3,7-dioxido-2,4,6,8,9-pentaoxa-1,3,5,7-tetraborabicyclo[3.3.1]nonane Chemical compound [Na+].[Na+].O1B([O-])OB2OB([O-])OB1O2 UQGFMSUEHSUPRD-UHFFFAOYSA-N 0.000 claims description 5
- 229910000027 potassium carbonate Inorganic materials 0.000 claims description 5
- 239000000429 sodium aluminium silicate Substances 0.000 claims description 5
- 235000012217 sodium aluminium silicate Nutrition 0.000 claims description 5
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 claims description 5
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 5
- 239000011780 sodium chloride Substances 0.000 claims description 5
- 239000011684 sodium molybdate Substances 0.000 claims description 5
- 235000015393 sodium molybdate Nutrition 0.000 claims description 5
- TVXXNOYZHKPKGW-UHFFFAOYSA-N sodium molybdate (anhydrous) Chemical compound [Na+].[Na+].[O-][Mo]([O-])(=O)=O TVXXNOYZHKPKGW-UHFFFAOYSA-N 0.000 claims description 5
- 235000010339 sodium tetraborate Nutrition 0.000 claims description 5
- 239000004328 sodium tetraborate Substances 0.000 claims description 5
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 claims description 5
- 235000019345 sodium thiosulphate Nutrition 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 4
- 241000282461 Canis lupus Species 0.000 claims 4
- 230000036039 immunity Effects 0.000 abstract description 14
- 230000000968 intestinal effect Effects 0.000 abstract description 6
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract description 4
- 229910021529 ammonia Inorganic materials 0.000 abstract description 2
- 239000003674 animal food additive Substances 0.000 abstract description 2
- 235000013594 poultry meat Nutrition 0.000 description 37
- 230000000694 effects Effects 0.000 description 16
- 238000012360 testing method Methods 0.000 description 14
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- 230000006870 function Effects 0.000 description 4
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- 206010062016 Immunosuppression Diseases 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 3
- 208000004880 Polyuria Diseases 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 235000013330 chicken meat Nutrition 0.000 description 3
- CYDMQBQPVICBEU-XRNKAMNCSA-N chlortetracycline Chemical group C1=CC(Cl)=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-XRNKAMNCSA-N 0.000 description 3
- 230000029087 digestion Effects 0.000 description 3
- 230000035619 diuresis Effects 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 230000002496 gastric effect Effects 0.000 description 3
- 230000001506 immunosuppresive effect Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- 210000003205 muscle Anatomy 0.000 description 3
- 230000035772 mutation Effects 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 230000028327 secretion Effects 0.000 description 3
- 210000005070 sphincter Anatomy 0.000 description 3
- 210000000952 spleen Anatomy 0.000 description 3
- 206010059866 Drug resistance Diseases 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 238000009395 breeding Methods 0.000 description 2
- 230000001488 breeding effect Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 241000411851 herbal medicine Species 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
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- 230000004048 modification Effects 0.000 description 2
- 238000005457 optimization Methods 0.000 description 2
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- 230000002265 prevention Effects 0.000 description 2
- 230000000529 probiotic effect Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000004099 Chlortetracycline Substances 0.000 description 1
- 208000035240 Disease Resistance Diseases 0.000 description 1
- 208000005577 Gastroenteritis Diseases 0.000 description 1
- 241000282414 Homo sapiens Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000037273 Pathologic Processes Diseases 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000002180 anti-stress Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- CYDMQBQPVICBEU-UHFFFAOYSA-N chlorotetracycline Natural products C1=CC(Cl)=C2C(O)(C)C3CC4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-UHFFFAOYSA-N 0.000 description 1
- 229960004475 chlortetracycline Drugs 0.000 description 1
- 235000019365 chlortetracycline Nutrition 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000002550 fecal effect Effects 0.000 description 1
- 230000007661 gastrointestinal function Effects 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000010871 livestock manure Substances 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
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- 230000009054 pathological process Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- GOLXNESZZPUPJE-UHFFFAOYSA-N spiromesifen Chemical compound CC1=CC(C)=CC(C)=C1C(C(O1)=O)=C(OC(=O)CC(C)(C)C)C11CCCC1 GOLXNESZZPUPJE-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
- A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
- A23K10/18—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/22—Compounds of alkali metals
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/26—Compounds containing phosphorus
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/28—Silicates, e.g. perlites, zeolites or bentonites
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/30—Oligoelements
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A—HUMAN NECESSITIES
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- A61K33/42—Phosphorus; Compounds thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/742—Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/76—Salicaceae (Willow family), e.g. poplar
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Polymers & Plastics (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Inorganic Chemistry (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Mycology (AREA)
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- Botany (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
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- Organic Chemistry (AREA)
- Physiology (AREA)
- Birds (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Fodder In General (AREA)
- Feed For Specific Animals (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention relates to a composition for preventing livestock and poultry diarrhea and a preparation method thereof, wherein the composition is prepared from the following components in parts by mass: 1-15 parts of poria extract, 1-15 parts of astragalus extract, 1-15 parts of poplar flower extract, 1-15 parts of fulvic acid, 1-8 parts of mineral ions, 0.01-0.08 part of bacillus subtilis and 70-160 parts of purified water. The feed additive can obviously enhance the immunity of livestock and poultry, improve the intestinal micro-ecological environment, improve the diarrhea condition of the livestock and poultry, improve the excrement and reduce the ammonia concentration in the livestock and poultry house.
Description
Technical Field
The invention relates to the field of feed and feed additives, in particular to a composition for preventing livestock and poultry diarrhea and a preparation method thereof.
Background
In the modern high-density and large-scale livestock and poultry breeding process, diarrhea is a common frequently-occurring disease of various livestock and poultry, the morbidity and the mortality are high, the growth performance of the livestock and poultry is seriously influenced, and if the prevention and the treatment are not timely, huge economic loss can be caused to a farm.
The diarrhea is an independent disease and a symptom in the pathological process of various diseases, gastroenteritis and diarrhea syndrome of livestock and poultry is a global problem, the development of the breeding industry is troubled for a long time, the disease is wide in prevalence and is developed all year round, even if the livestock and poultry survive to death, the growth of the livestock and poultry is slow, the feed reward is reduced, and the great economic loss is caused.
At present, antibiotic medicines are mainly adopted for clinically preventing and treating livestock and poultry diarrhea, although the curative effect is exact, the serious drug resistance can be generated, the immunity and the disease resistance of animals are gradually reduced, organism residues are caused, and potential food safety hazards are left for human beings. With the improvement of living standard and the enhancement of self-protection consciousness of people, more and more attention is paid to the safety of food, and more countries in the world have started to forbid or limit the use of antibiotics and chemosynthetic drugs as compositions so as to solve the problem of antibiotic residue in food from the source.
Chinese herbal medicine which is a traditional resource in China contains various bioactive substances, and can resist bacteria, diminish inflammation, enhance the immune function of an organism, improve the anti-stress and anti-disease capability of animals and improve the production performance of the animals. The Chinese herbal medicine has the characteristics of difficult generation of bacterial drug resistance, low toxicity, no residue or low residue and the like, has double effects of medicine and nutritional agents, and has unique advantages in preventing and treating diarrhea diseases of livestock and poultry.
Disclosure of Invention
The composition can obviously enhance the immunity of livestock and poultry, improve the intestinal micro-ecological environment, improve the diarrhea condition of the livestock and poultry, improve the excrement and reduce the ammonia concentration in a livestock house.
In order to achieve the purpose, the invention provides the following technical scheme: the composition for preventing livestock and poultry diarrhea is prepared from the following components in parts by mass: 1-15 parts of poria extract, 1-15 parts of astragalus extract, 1-15 parts of poplar flower extract, 1-15 parts of fulvic acid, 1-8 parts of mineral ions, 0.01-0.08 part of bacillus subtilis and 70-160 parts of purified water.
The further optimized scheme is that the composition for preventing livestock and poultry diarrhea is prepared from the following components in parts by mass: 4-10 parts of poria extract, 5-10 parts of astragalus extract, 5-10 parts of poplar flower extract, 5-10 parts of fulvic acid, 3-6 parts of mineral ions, 0.03-0.06 part of bacillus subtilis and 77-130 parts of purified water.
The further optimized scheme is that the composition for preventing livestock and poultry diarrhea is prepared from the following components in parts by mass: 5 parts of poria cocos extract, 5 parts of astragalus membranaceus extract, 5 parts of poplar flower extract, 5 parts of fulvic acid, 3 parts of mineral ions, 0.05 part of bacillus subtilis and 77 parts of purified water.
The further optimized proposal is that the tuckahoe extract is prepared by soaking, decocting, filtering and concentrating tuckahoe; the radix astragali extract is prepared by soaking dried root of radix astragali, decocting, filtering, and concentrating; the poplar flower extract is prepared by soaking flower of Populus plant of Salicaceae, decocting, filtering, and concentrating.
The further optimization scheme is that the mineral ions are prepared from the following components in parts by mass: 40 parts of disodium hydrogen phosphate, 10 parts of potassium carbonate, 6 parts of sodium carbonate, 4 parts of sodium chloride, 2 parts of sodium tetraborate, 2 parts of sodium molybdate, 20 parts of sodium aluminosilicate and 5 parts of sodium thiosulfate.
A preparation method of a composition for preventing livestock and poultry diarrhea comprises the following steps: 1-15 parts of poria extract, 1-15 parts of astragalus extract, 1-15 parts of poplar flower extract, 1-15 parts of fulvic acid, 1-8 parts of mineral ions, 0.01-0.08 part of bacillus subtilis and 70-160 parts of purified water are uniformly mixed, and then the mixture is aerated and fermented at constant temperature of 30-37 ℃ for 3-4 days, the pH value is reduced to 4, and impurities are removed by filtering.
The preparation method of the composition for preventing livestock and poultry diarrhea further comprises the following steps: uniformly mixing 5 parts of poria cocos extract, 5 parts of astragalus extract, 5 parts of poplar flower extract, 5 parts of fulvic acid, 3 parts of mineral ions, 0.05 part of bacillus subtilis and 77 parts of purified water, then ventilating and fermenting at constant temperature of 30-37 ℃ for 3-4 days, reducing the pH to 4, and filtering to remove impurities.
The further optimized proposal is that the tuckahoe extract is prepared by soaking, decocting, filtering and concentrating tuckahoe; the radix astragali extract is prepared by soaking dried root of radix astragali, decocting, filtering, and concentrating; the poplar flower extract is prepared by soaking flower of Populus plant of Salicaceae, decocting, filtering, and concentrating.
The further optimization scheme is that the mineral ions are prepared from the following components in parts by mass: 40 parts of disodium hydrogen phosphate, 10 parts of potassium carbonate, 6 parts of sodium carbonate, 4 parts of sodium chloride, 2 parts of sodium tetraborate, 2 parts of sodium molybdate, 20 parts of sodium aluminosilicate and 5 parts of sodium thiosulfate.
Preferably, the bacillus subtilis is preserved in the China center for type culture Collection, and the strain number: B99906-AN1, the preservation number is CCTCC NO: m2020583.
The composition for preventing livestock and poultry diarrhea has the following advantages: the invention adopts the tuckahoe extract, the astragalus extract and the poplar flower extract to promote the immunity of the livestock and improve the digestive system function of the livestock and poultry. Fulvic acid can be used for improving immunity and regulating gastrointestinal function. The bacillus subtilis is fermented, so that the effective components of the components are fully released, the bacillus subtilis is convenient for livestock and poultry to absorb, and the microbial supplementation can improve the intestinal microbial flora of the livestock and poultry, so that additive effects are presented among the components, and the diarrhea of the livestock and poultry is effectively prevented.
Detailed Description
The specific embodiment is as follows:
the composition for preventing livestock and poultry diarrhea is prepared from the following components in parts by mass: 1-15 parts of poria extract, 1-15 parts of astragalus extract, 1-15 parts of poplar flower extract, 1-15 parts of fulvic acid, 1-8 parts of mineral ions, 0.01-0.08 part of bacillus subtilis and 70-160 parts of purified water.
A preparation method of a composition for preventing livestock and poultry diarrhea comprises the following steps: 1-15 parts of poria extract, 1-15 parts of astragalus extract, 1-15 parts of poplar flower extract, 1-15 parts of fulvic acid, 1-8 parts of mineral ions, 0.01-0.08 part of bacillus subtilis and 70-160 parts of purified water are uniformly mixed, and then the mixture is aerated and fermented at constant temperature of 30-37 ℃ for 3-4 days, the pH value is reduced to 4, and impurities are removed by filtering.
The poria cocos extract is prepared by soaking, decocting, filtering and concentrating poria cocos; the radix astragali extract is prepared by soaking dried root of radix astragali, decocting, filtering, and concentrating; the poplar flower extract is prepared by soaking flower of Populus plant of Salicaceae, decocting, filtering, and concentrating.
The mineral ions are prepared from the following components in parts by mass: 40 parts of disodium hydrogen phosphate, 10 parts of potassium carbonate, 6 parts of sodium carbonate, 4 parts of sodium chloride, 2 parts of sodium tetraborate, 2 parts of sodium molybdate, 20 parts of sodium aluminosilicate and 5 parts of sodium thiosulfate.
The bacillus subtilis is preserved in China center for type culture Collection, and has the strain number: B99906-AN1, the preservation number is CCTCC NO: m2020583.
The specific implementation mode is as follows:
example 1
The composition for preventing livestock and poultry diarrhea is prepared from the following components in parts by mass:
4 parts of poria cocos extract, 6 parts of astragalus membranaceus extract, 7 parts of poplar flower extract, 6 parts of fulvic acid, 3 parts of mineral ions, 0.05 part of bacillus subtilis and 74 parts of purified water.
A preparation method of a composition for preventing livestock and poultry diarrhea comprises the following steps: mixing Poria extract 4 parts, radix astragali extract 6 parts, poplar flower extract 7 parts, fulvic acid 6 parts, mineral ions 3 parts, Bacillus subtilis 0.05 parts, and purified water 74 parts, fermenting at 30-37 deg.C under constant temperature and ventilation for 3-4 days, reducing pH to 4, and filtering to remove impurities.
Poria extract has effects in improving immunity, promoting diuresis, invigorating spleen, resisting bacteria, lowering blood sugar, and resisting tumor. The radix astragali extract has effects of enhancing immunity, enhancing energy, relieving fatigue, resisting mutation, and protecting liver. The poplar flower extract can improve the resistance of organisms, resist immunosuppression, regulate the immune function of the organisms, effectively relieve various stress reactions of livestock and poultry during the disease attack period, promote digestion, improve the tension of gastrointestinal muscles and sphincters of animals, inhibit secretion function and show the effects of astringing and stopping diarrhea. The extract is matched with probiotics, so that the immunity of animals can be obviously enhanced, the intestinal flora of the animals can be improved, and the diarrhea incidence rate can be greatly reduced.
Example 2
The composition for preventing livestock and poultry diarrhea is prepared from the following components in parts by mass:
5 parts of poria cocos extract, 5 parts of astragalus membranaceus extract, 5 parts of poplar flower extract, 5 parts of fulvic acid, 3 parts of mineral ions, 0.05 part of bacillus subtilis and 77 parts of purified water.
A preparation method of a composition for preventing livestock and poultry diarrhea comprises the following steps: mixing Poria extract 5 parts, radix astragali extract 5 parts, poplar flower extract 5 parts, fulvic acid 5 parts, mineral ions 3 parts, Bacillus subtilis 0.05 parts, and purified water 77 parts, fermenting at 30-37 deg.C under constant temperature and ventilation for 3-4 days, reducing pH to 4, and filtering to remove impurities.
Poria extract has effects in improving immunity, promoting diuresis, invigorating spleen, resisting bacteria, lowering blood sugar, and resisting tumor. The radix astragali extract has effects of enhancing immunity, enhancing energy, relieving fatigue, resisting mutation, and protecting liver. The poplar flower extract can improve the resistance of organisms, resist immunosuppression, regulate the immune function of the organisms, effectively relieve various stress reactions of livestock and poultry during the disease attack period, promote digestion, improve the tension of gastrointestinal muscles and sphincters of animals, inhibit secretion function and show the effects of astringing and stopping diarrhea. The extract is matched with probiotics, so that the immunity of animals can be obviously enhanced, the intestinal flora of the animals can be improved, and the diarrhea incidence rate can be greatly reduced.
Example 3
The composition for preventing livestock and poultry diarrhea is prepared from the following components in parts by mass:
10 parts of poria extract, 10 parts of astragalus extract, 10 parts of poplar flower extract, 8 parts of fulvic acid, 5 parts of mineral ions, 0.05 part of bacillus subtilis and 97 parts of purified water.
A preparation method of a composition for preventing livestock and poultry diarrhea comprises the following steps: mixing Poria extract 10 parts, radix astragali extract 10 parts, poplar flower extract 10 parts, fulvic acid 8 parts, mineral ions 5 parts, Bacillus subtilis 0.05 parts, and purified water 97 parts, fermenting at 30-37 deg.C under constant temperature and ventilation for 3-4 days, reducing pH to 4, and filtering to remove impurities.
Poria extract has effects in improving immunity, promoting diuresis, invigorating spleen, resisting bacteria, lowering blood sugar, and resisting tumor. The radix astragali extract has effects of enhancing immunity, enhancing energy, relieving fatigue, resisting mutation, and protecting liver. The poplar flower extract can improve the resistance of organisms, resist immunosuppression, regulate the immune function of the organisms, effectively relieve various stress reactions of livestock and poultry during the disease attack period, promote digestion, improve the tension of gastrointestinal muscles and sphincters of animals, inhibit secretion function and show the effects of astringing and stopping diarrhea. The extract is matched with probiotics, so that the immunity of animals can be obviously enhanced, the intestinal flora of the animals can be improved, and the diarrhea incidence rate can be greatly reduced.
Example 4
The composition for preventing livestock and poultry diarrhea is prepared from the following components in parts by mass:
1 part of poria extract, 1 part of astragalus extract, 1 part of poplar flower extract, 1 part of fulvic acid, 1 part of mineral ions, 0.01 part of bacillus subtilis and 70 parts of purified water.
A preparation method of a composition for preventing livestock and poultry diarrhea comprises the following steps: mixing Poria extract 1 part, radix astragali extract 1 part, poplar flower extract 1 part, fulvic acid 1 part, mineral ions 1 part, Bacillus subtilis 0.01 part, and purified water 70 parts, fermenting at 30-37 deg.C under constant temperature and ventilation for 3-4 days, reducing pH to 4, and filtering to remove impurities.
Example 5
The composition for preventing livestock and poultry diarrhea is prepared from the following components in parts by mass:
15 parts of poria cocos extract, 15 parts of astragalus membranaceus extract, 15 parts of poplar flower extract, 15 parts of fulvic acid, 8 parts of mineral ions, 0.08 part of bacillus subtilis and 160 parts of purified water.
A preparation method of a composition for preventing livestock and poultry diarrhea comprises the following steps: mixing Poria extract 15 parts, radix astragali extract 15 parts, poplar flower extract 15 parts, fulvic acid 15 parts, mineral ions 8 parts, Bacillus subtilis 0.08 parts, and purified water 160 parts, fermenting at 30-37 deg.C under constant temperature and ventilation for 3-4 days, reducing pH to 4, and filtering to remove impurities.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like made within the spirit and principle of the present invention should be included in the scope of the present invention.
Test example 1
(1) 90 weaned external three-element piglets of 28 days old are selected and randomly divided into 3 treatment groups, each treatment group has 5 repetitions, each repetition has 6 piglets, and the test period is 7 days. The grouping situation is as follows
TABLE 1 design of the experiments
(2) Measurement index
The diarrhea condition of piglets is mainly observed the diarrhea rate and diarrhea index of piglets of different treatment groups at 1 week after weaning, the feces of piglets are respectively observed at 9:00 and 17:00 every day in the experimental period, and the specific evaluation method is as follows
Grading the piglet feces: (0) the feces are in the form of strips or granules. (II) 1 minute, the manure is soft, and the shaping can be realized. ③ 2, thick, not shaped, and the liquid dung is not separated. Fourthly, 3, separating liquid, unformed and liquid dung. When the fecal score is 2 or more than 2, the piglets are considered to have diarrhea, and the diarrhea rate and the diarrhea index of the piglets are calculated for 0-7 d.
The diarrhea index is the sum of diarrhea scores of piglets in each treatment group within 0-7 d/(test days multiplied by the number of piglets in each group);
the diarrhea rate (%) is 0-7 d, and the number of diarrhea heads of each treated group of piglets/(test days multiplied by the number of heads of each group of piglets) is calculated.
(3) The test results are as follows
TABLE 2 results of the Effect of different treatments on the diarrhea status of weaned piglets
As can be seen from Table 2, compared with the control group, the use of the antibiotics and the invention can significantly reduce the diarrhea rate of weaned piglets and lower the diarrhea index, and the effect of the invention is slightly better than that of the antibiotics group.
Therefore, the composition can effectively reduce the diarrhea rate of weaned piglets and reduce the occurrence of diarrhea.
Test example 2
288 AA broilers of 0 day old were selected and randomly divided into 4 treatment groups, each treatment was repeated 6 times, each treatment was repeated 12 times, and the test period was 42 days. The grouping situation is as follows
TABLE 3 test design
(2) Measurement index
The health of the test chickens was observed daily at regular intervals and the number of diarrhea chickens and the number of dead chicks were recorded, the criterion for diarrhea being the visible adhesion of dry or dilute wet faeces in the cloacal orifice. And respectively calculating the diarrhea rate and the death and culling rate of the test chickens of each treatment group by taking the repetition as a statistical unit.
(3) The test results are as follows
TABLE 4 Effect of different treatments on diarrhea in weaned piglets
Note: data in the same row with different letters indicates significant difference (P < 0.05), and with no label or same letter indicates insignificant difference (P > 0.05).
As can be seen from Table 4, diarrhea of broilers of each treatment group mainly appeared at 0-3 weeks of age; the diarrhea rate of 0-3 weeks old and the whole course (0-6 weeks) is the lowest by taking the aureomycin group as the lowest, and the comparison group is more than the probiotic group and more than the test group and more than the aureomycin group (P is less than 0.05); the diarrhea rate is highest in a control group at 3-6 weeks of age, wherein the control group is more than a chlortetracycline probiotic group and more than a test group (P is less than 0.05). In the test process, the death and culling rate of the broilers in each group is very low, only sporadic cases occur, and the difference between treatment groups is not obvious (P is more than 0.05).
Therefore, the composition can effectively reduce the occurrence of diarrhea of the broiler chicken, and the effect is only second to the whole-course addition of antibiotics.
In conclusion, the components of the composition have good synergistic effect, can obviously reduce the occurrence of livestock diarrhea, and has good prevention and treatment effect on the livestock diarrhea.
The above description is only a preferred embodiment of the present invention, and the protection scope of the present invention is not limited to the above embodiments, and all technical solutions belonging to the idea of the present invention belong to the protection scope of the present invention. It should be noted that modifications and embellishments within the scope of the invention may occur to those skilled in the art without departing from the principle of the invention, and are considered to be within the scope of the invention.
Claims (9)
1. The composition for preventing livestock and poultry diarrhea is characterized by being prepared from the following components in parts by mass:
1-15 parts of poria extract, 1-15 parts of astragalus extract, 1-15 parts of poplar flower extract, 1-15 parts of fulvic acid, 1-8 parts of mineral ions, 0.01-0.08 part of bacillus subtilis and 70-160 parts of purified water.
2. The composition for preventing livestock and poultry diarrhea according to claim 1 is characterized by being prepared from the following components in parts by mass:
4-10 parts of poria extract, 5-10 parts of astragalus extract, 5-10 parts of poplar flower extract, 5-10 parts of fulvic acid, 3-6 parts of mineral ions, 0.03-0.06 part of bacillus subtilis and 77-130 parts of purified water.
3. The composition for preventing livestock and poultry diarrhea according to claim 1 is characterized by being prepared from the following components in parts by mass:
5 parts of poria cocos extract, 5 parts of astragalus membranaceus extract, 5 parts of poplar flower extract, 5 parts of fulvic acid, 3 parts of mineral ions, 0.05 part of bacillus subtilis and 77 parts of purified water.
4. The composition for preventing diarrhea in livestock and poultry according to claim 1, wherein said Poria cocos wolf extract is an extract obtained by soaking Poria cocos wolf, decocting, filtering, and concentrating; the radix astragali extract is prepared by soaking dried root of radix astragali, decocting, filtering, and concentrating; the poplar flower extract is prepared by soaking flower of Populus plant of Salicaceae, decocting, filtering, and concentrating.
5. The composition for preventing livestock and poultry diarrhea according to claim 1, wherein the mineral ions are prepared from the following components in parts by mass: 40 parts of disodium hydrogen phosphate, 10 parts of potassium carbonate, 6 parts of sodium carbonate, 4 parts of sodium chloride, 2 parts of sodium tetraborate, 2 parts of sodium molybdate, 20 parts of sodium aluminosilicate and 5 parts of sodium thiosulfate.
6. The method for preparing the composition for preventing diarrhea in livestock and poultry according to claim 1, comprising the steps of: 1-15 parts of poria extract, 1-15 parts of astragalus extract, 1-15 parts of poplar flower extract, 1-15 parts of fulvic acid, 1-8 parts of mineral ions, 0.01-0.08 part of bacillus subtilis and 70-160 parts of purified water are uniformly mixed, and then the mixture is aerated and fermented at constant temperature of 30-37 ℃ for 3-4 days, the pH value is reduced to 4, and impurities are removed by filtering.
7. The preparation method of the composition for preventing diarrhea in livestock and poultry according to claim 6, comprising the steps of: uniformly mixing 5 parts of poria cocos extract, 5 parts of astragalus extract, 5 parts of poplar flower extract, 5 parts of fulvic acid, 3 parts of mineral ions, 0.05 part of bacillus subtilis and 77 parts of purified water, then ventilating and fermenting at constant temperature of 30-37 ℃ for 3-4 days, reducing the pH to 4, and filtering to remove impurities.
8. The method for preparing a composition for preventing diarrhea in livestock and poultry according to claim 6, wherein the Poria cocos wolf extract is an extract obtained by soaking Poria cocos wolf, decocting, filtering, and concentrating; the radix astragali extract is prepared by soaking dried root of radix astragali, decocting, filtering, and concentrating; the poplar flower extract is prepared by soaking flower of Populus plant of Salicaceae, decocting, filtering, and concentrating.
9. The preparation method of the composition for preventing livestock and poultry diarrhea according to claim 6 is characterized in that the mineral ions are prepared from the following components in parts by mass: 40 parts of disodium hydrogen phosphate, 10 parts of potassium carbonate, 6 parts of sodium carbonate, 4 parts of sodium chloride, 2 parts of sodium tetraborate, 2 parts of sodium molybdate, 20 parts of sodium aluminosilicate and 5 parts of sodium thiosulfate.
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| CN115837049A (en) * | 2022-11-14 | 2023-03-24 | 江苏南京农大动物药业有限公司 | Compound poplar flower oral liquid for preventing and treating livestock and poultry diarrhea and preparation method thereof |
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