CN112438945A - Washing-free disinfection gel and preparation method thereof - Google Patents
Washing-free disinfection gel and preparation method thereof Download PDFInfo
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- CN112438945A CN112438945A CN202011379406.7A CN202011379406A CN112438945A CN 112438945 A CN112438945 A CN 112438945A CN 202011379406 A CN202011379406 A CN 202011379406A CN 112438945 A CN112438945 A CN 112438945A
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- hpmc
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- washing
- ethanol
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- 238000004659 sterilization and disinfection Methods 0.000 title claims abstract description 44
- 238000002360 preparation method Methods 0.000 title abstract description 15
- 238000001879 gelation Methods 0.000 title description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 69
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims abstract description 42
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims abstract description 41
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 30
- 238000003756 stirring Methods 0.000 claims description 21
- -1 hydroxypropoxyl Chemical group 0.000 claims description 18
- 239000008213 purified water Substances 0.000 claims description 10
- 238000002834 transmittance Methods 0.000 claims description 9
- 239000007864 aqueous solution Substances 0.000 claims description 4
- GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical group [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 claims description 4
- 239000000686 essence Substances 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 244000021317 Annona cherimola Species 0.000 claims description 2
- 235000005979 Citrus limon Nutrition 0.000 claims description 2
- 244000131522 Citrus pyriformis Species 0.000 claims description 2
- 240000002319 Citrus sinensis Species 0.000 claims description 2
- 235000005976 Citrus sinensis Nutrition 0.000 claims description 2
- 235000010254 Jasminum officinale Nutrition 0.000 claims description 2
- 240000005385 Jasminum sambac Species 0.000 claims description 2
- 244000178870 Lavandula angustifolia Species 0.000 claims description 2
- 235000010663 Lavandula angustifolia Nutrition 0.000 claims description 2
- 235000011430 Malus pumila Nutrition 0.000 claims description 2
- 235000015103 Malus silvestris Nutrition 0.000 claims description 2
- 235000006679 Mentha X verticillata Nutrition 0.000 claims description 2
- 235000002899 Mentha suaveolens Nutrition 0.000 claims description 2
- 235000001636 Mentha x rotundifolia Nutrition 0.000 claims description 2
- 239000001102 lavandula vera Substances 0.000 claims description 2
- 235000018219 lavender Nutrition 0.000 claims description 2
- 230000002421 anti-septic effect Effects 0.000 claims 7
- 239000002131 composite material Substances 0.000 claims 2
- 239000000645 desinfectant Substances 0.000 abstract description 9
- 238000001035 drying Methods 0.000 abstract description 7
- 239000000499 gel Substances 0.000 description 44
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 35
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 35
- 235000019441 ethanol Nutrition 0.000 description 21
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 7
- 229920002125 Sokalan® Polymers 0.000 description 7
- 229960001631 carbomer Drugs 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 239000000243 solution Substances 0.000 description 6
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 4
- 238000004140 cleaning Methods 0.000 description 3
- 230000000249 desinfective effect Effects 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 241000700605 Viruses Species 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 238000009775 high-speed stirring Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 230000036620 skin dryness Effects 0.000 description 2
- 239000000344 soap Substances 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention belongs to the field of disinfectants, and particularly relates to a washing-free disinfection gel and a preparation method thereof. The invention aims to solve the technical problem of providing a no-clean disinfection gel which comprises the following components in percentage by mass: 70-75% of ethanol, 0.5-1% of HPMC and the balance of water. The washing-free disinfection gel has the advantages of moderate viscosity, easy uniform smearing, high drying speed and less residues; meanwhile, the situations of dry and rough skin and the like of the common alcohol disinfectant after use can not occur.
Description
Technical Field
The invention belongs to the field of disinfectants, and particularly relates to a washing-free disinfection gel and a preparation method thereof.
Background
Various microorganisms exist in the nature, some microorganisms threaten the health of human bodies, and the microorganisms are easily spread along with the contact of people, so that the cleaning and disinfection are common protective measures, wherein the hand washing is the most basic cleaning and disinfection mode. While the household generally uses soap, perfumed soap and hand sanitizer to wash hands, the wash-free disinfecting gel can be used under special conditions, such as rapid disinfection of hands in crowded places like stations and hospitals, or cleaning and disinfection of hands under outdoor water shortage conditions.
At present, alcohol is commonly used as a disinfectant, or the alcohol and other disinfectants are used together, and ethanol is most widely used. Ethanol has a dehydrating effect and can coagulate proteins, resulting in the death of pathogenic bacteria. The ethanol has a remarkable effect of inhibiting the activity of gram-negative bacteria, gram-positive bacteria, envelope viruses and various fungi in vitro, can kill bacterial propagules, and has a strong effect of killing most lipophilic viruses.
At present, the disposable disinfection gel taking ethanol as a disinfectant has various types, but carbomer is generally used as a thickening agent, and the imported carbomer is mainly used. The imported carbomer is high in price, and a carbomer substitute product is always searched domestically.
Disclosure of Invention
Aiming at the defects in the prior art, HPMC (hydroxypropyl methyl cellulose) is used for replacing carbomer as a thickening agent of the alcohol type no-clean disinfection gel to prepare the no-clean disinfection gel. The washing-free disinfection gel obtained by the invention has the advantages of moderate viscosity, easy uniform smearing, high drying speed and less residues; meanwhile, the HPMC has better water retention effect, so that the no-clean disinfection gel provided by the invention can not cause the situations of dry and rough skin and the like after the common alcohol disinfectant is used.
The washing-free disinfection gel comprises the following components in percentage by mass: 70-75% of ethanol, 0.5-1% of HPMC and the balance of water.
Further, the HPMC meets the following requirements of the no-clean disinfection gel: the content of methoxyl is 28-30%, the content of hydroxypropoxyl is 7-12%, the light transmittance of 2% aqueous solution is more than 90%, and the viscosity (20 ℃, 2%, NDJ, the same below) is 40000 mpa.s-150000 mpa.s. The other indexes meet the index requirements of HPMC as medicinal auxiliary material in China pharmacopoeia 2020 edition.
Further, the no-clean disinfection gel comprises the following components in percentage by mass: 75% of ethanol, 0.75% of HPMC and the balance of water; wherein the HPMC meets the following requirements: 29 percent of methoxyl group content, 10 percent of hydroxypropoxyl group content, more than 90 percent of light transmittance of 2 percent of water solution and 75000mpa.s of viscosity.
Further, in the washing-free disinfecting gel, the ethanol is absolute ethanol.
Further, in the washing-free disinfecting gel, the water is purified water.
Furthermore, the components of the no-clean disinfection gel also comprise essence. The essence is one or more of lemon, jasmine, lavender, mint, sweet orange and apple.
Furthermore, 0.1-1% of essence is added in the no-clean disinfection gel.
The invention also provides a preparation method of the washing-free disinfection gel. The preparation method comprises the following steps: adding HPMC into ethanol, stirring, adding water or essence and water, and stirring.
The washing-free disinfection gel has wide raw material source and low price, and the HPMC is easy to dissolve in ethanol and aqueous solution at normal temperature, and the preparation process is simple. The washing-free disinfection gel obtained by the invention has the advantages of moderate viscosity, easy uniform smearing, high drying speed and less residues; meanwhile, the HPMC has better water retention effect, so that the no-clean disinfection gel provided by the invention can not cause the situations of dry and rough skin and the like after the common alcohol disinfectant is used.
Detailed Description
The washing-free disinfection gel comprises the following components in percentage by mass: 70-75% of ethanol, 0.5-1% of HPMC and the balance of water.
Preferably, the no-clean disinfection gel comprises the following components in percentage by mass: 75% of ethanol, 0.75% of HPMC and the balance of water; wherein the HPMC meets the following requirements: 29 percent of methoxyl group content, 10 percent of hydroxypropoxyl group content, more than 90 percent of light transmittance of 2 percent of water solution and 75000mpa.s of viscosity.
Furthermore, the components of the no-clean disinfection gel also comprise essence. 0.1-1% of essence is added.
The invention also provides a preparation method of the washing-free disinfection gel, which comprises the following steps:
1. weighing absolute ethyl alcohol, HPMC, purified water, or absolute ethyl alcohol, HPMC, purified water, and essence according to formula ratio;
2. adding absolute ethyl alcohol into a batching tank, and starting stirring at a stirring speed of 60-80 r/min;
3. adding HPMC into a mixing tank, and continuously stirring for 5-10 min;
4. slowly adding purified water into the material preparation tank, continuously stirring, and continuously stirring for 20-30 min after the water is added to obtain a finished product; or slowly adding purified water into the mixing tank, adding essence, continuously stirring, and continuously stirring for 20-30 min after the water is added to obtain a finished product.
Test examples
Table 1 shows the disinfectant gels prepared by dissolving a common grade of HPMC product in a 75% ethanol solution.
TABLE 1 Disinfection gel test data for common HPMC designations
From the data, it can be seen that HPMC with 21% of methoxyl group and 7.5% of hydroxypropoxyl group and HPMC with 27.5% of methoxyl group and 5.5% of hydroxypropoxyl group can not be fully dissolved in 75% ethanol solution, the thickening effect is poor, and the prepared disinfection gel has poor light transmittance which is below 50%.
HPMC with 29% of methoxyl group content and 10% of hydroxypropoxyl group content can be fully dissolved in 75% ethanol solution, and the formed solution has high light transmittance which is over 96%. Therefore, the HPMC is selected to be a substitution type with the methoxy content of 29 percent and the hydroxypropoxy content of 10 percent, and the substitution type product has the methoxy content of 28 to 30 percent and the hydroxypropoxy content of 7 to 12 percent.
From the use hand feeling of the prepared washing-free disinfection gel, when the addition amount of the HPMC is 2% (namely the number is 5-8), the use hand feeling is greasy, the gel can be completely dried about 40-60 seconds after being smeared, and certain residues exist after the gel is dried.
The HPMC is added in the amount of 0.5%, 0.75% and 1% (namely the serial number is 9-20), the hand feeling is refreshing, the drying can be completed 10-20 seconds after the coating, and no obvious residue is left after the use. Further, the prepared disinfection gel is easy to drip and not easy to be evenly smeared in the smearing process when the viscosity is too low, has greasy feeling after being smeared when the viscosity is too high, is long in drying time, and has good comprehensive use hand feeling when the viscosity is 500-4500 mpa.s.
It has been found that when the amount of HPMC is 1% or more, the feeling of residue after use is observed, and therefore, the amount of HPMC added is controlled to 1% or less in the present invention. Meanwhile, HPMC products with the methoxyl content of 28-30 percent and the hydroxypropoxyl content of 7-12 percent are difficult to produce when the viscosity is 150000mpa.s or above, and the HPMC with the viscosity below 40000mpa.s needs more than 1 percent of addition amount to ensure that the disinfection gel has enough viscosity, so the viscosity model of the HPMC is selected to be 40000-150000 mpa.s.
Example 1
The model of HPMC is selected as HG75000 (methoxy content is 29%, hydroxypropoxy content is 10%, viscosity is 70000mpa.s), and 750g of absolute ethyl alcohol, 7.5g of HPMCH and 242.5g of purified water are respectively weighed.
And adding weighed absolute ethyl alcohol into the batching container, starting stirring, and stirring at the rotating speed of 60 r/min.
Add weighed HPMC to the batching vessel and continue stirring for 5 min.
And slowly adding weighed purified water into the proportioning container, continuously stirring, and continuously stirring for 20min after the water is added to obtain a finished product.
The preparation process of the washing-free disinfection gel is less than 1 hour, the preparation period is greatly shortened compared with that of the disinfection gel prepared by carbomer, the preparation process is simple, and heating or high-speed stirring is not needed.
The viscosity of the prepared washing-free disinfection gel is 4100mpa.s, the light transmittance is 99.1%, the gel is refreshing and non-greasy in use hand feeling, drying can be completed within 10-20 seconds after the gel is smeared, and no obvious residue is left after the gel is used. Because HPMC has better water retention function, the no-clean disinfection gel of the invention can not cause the skin dryness after the disinfection of common alcohol after use.
Example 2
The model of HPMC is selected as HG100000 (methoxy content is 29%, hydroxypropoxy content is 10%, viscosity is 115000mpa.s), and 750g of absolute ethyl alcohol, 750g of HPMC5g and 245g of purified water are respectively weighed.
And adding weighed absolute ethyl alcohol into the batching container, starting stirring, and stirring at the rotating speed of 60 r/min.
Add weighed HPMC to the batching vessel and continue stirring for 5 min.
And slowly adding weighed purified water into the proportioning container, continuously stirring, and continuously stirring for 20min after the water is added to obtain a finished product.
The preparation process of the washing-free disinfection gel is less than 1 hour, the preparation period is greatly shortened compared with that of the disinfection gel prepared by carbomer, the preparation process is simple, and heating or high-speed stirring is not needed.
The viscosity of the prepared washing-free disinfection gel is 950mpa.s, the light transmittance is 99.3%, the hand feeling is refreshing and not greasy, the drying can be completed 10-20 seconds after the gel is smeared, and no obvious residue is left after the gel is used. Because HPMC has better water retention function, the no-clean disinfection gel of the invention can not cause the skin dryness after the disinfection of common alcohol after use.
Claims (8)
1. The washing-free disinfection gel is characterized in that: the composite material comprises the following components in percentage by mass: 70-75% of ethanol, 0.5-1% of HPMC and the balance of water.
2. The leave-in antiseptic gel of claim 1, wherein: the HPMC meets the following requirements: the content of methoxyl is 28-30%, the content of hydroxypropoxyl is 7-12%, the light transmittance of 2% aqueous solution is more than 90%, and the viscosity is 40000 mpa.s-150000 mpa.s.
3. The leave-in antiseptic gel of claim 2, wherein: the composite material comprises the following components in percentage by mass: 75% of ethanol, 0.75% of HPMC and the balance of water; wherein the HPMC meets the following requirements: the content of methoxyl is 29 percent, the content of hydroxypropoxyl is 10 percent, the light transmittance of 2 percent aqueous solution is more than 90 percent, and the viscosity is 75000 mpa.s.
4. A leave-on antiseptic gel according to any one of claims 1 to 3 wherein: the ethanol is absolute ethanol.
5. A leave-on antiseptic gel according to any one of claims 1 to 4, wherein: the water is purified water.
6. A leave-on antiseptic gel according to any one of claims 1 to 5, wherein: the components also comprise essence; further, the essence is one or more of lemon, jasmine, lavender, mint, sweet orange and apple.
7. The leave-in antiseptic gel of claim 6, wherein: 0.1-1% of essence is added.
8. A method of preparing a leave-on antiseptic gel as defined in any of claims 1 to 7, characterized in that: the method comprises the following steps: adding HPMC into ethanol, stirring, adding water or essence and water, and stirring.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011379406.7A CN112438945A (en) | 2020-11-30 | 2020-11-30 | Washing-free disinfection gel and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011379406.7A CN112438945A (en) | 2020-11-30 | 2020-11-30 | Washing-free disinfection gel and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112438945A true CN112438945A (en) | 2021-03-05 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011379406.7A Pending CN112438945A (en) | 2020-11-30 | 2020-11-30 | Washing-free disinfection gel and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113244322A (en) * | 2021-05-06 | 2021-08-13 | 常州美康源医疗科技有限公司 | Hand-washing-free disinfectant |
Citations (9)
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|---|---|---|---|---|
| US4614545A (en) * | 1985-08-15 | 1986-09-30 | The Dow Chemical Company | Hydroxypropyl methyl cellulose thickening agents for organic liquids |
| CA1312859C (en) * | 1985-02-28 | 1993-01-19 | The Dow Chemical Company | Hydroxypropyl methyl cellulose ethers useful as thickening agents for organic liquids |
| US5750579A (en) * | 1992-12-28 | 1998-05-12 | Toko Yakuhin Kogyo Kabushiki Kaisha | Quick-drying gel-type disinfectant for hands and fingers |
| EP1964576A1 (en) * | 2007-02-27 | 2008-09-03 | Certmedica International GmbH | Aqueous disinfectant gel preparation |
| JP2010047554A (en) * | 2008-08-25 | 2010-03-04 | Niitaka:Kk | Alcohol gel disinfectant composition |
| JP2011173823A (en) * | 2010-02-24 | 2011-09-08 | Hisamitsu Pharmaceut Co Inc | Gel preparation |
| WO2017077872A1 (en) * | 2015-11-05 | 2017-05-11 | エステー株式会社 | Alcohol-based gel composition and method for producing same |
| CN111264558A (en) * | 2020-04-07 | 2020-06-12 | 河南省奥林特药业有限公司 | Wash-free gel disinfectant for inhibiting ethanol volatilization and preparation process thereof |
| CN111714424A (en) * | 2020-08-07 | 2020-09-29 | 泰州市榕兴医疗用品股份有限公司 | Hand-washing-free disinfection gel |
-
2020
- 2020-11-30 CN CN202011379406.7A patent/CN112438945A/en active Pending
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| US4614545A (en) * | 1985-08-15 | 1986-09-30 | The Dow Chemical Company | Hydroxypropyl methyl cellulose thickening agents for organic liquids |
| US5750579A (en) * | 1992-12-28 | 1998-05-12 | Toko Yakuhin Kogyo Kabushiki Kaisha | Quick-drying gel-type disinfectant for hands and fingers |
| EP1964576A1 (en) * | 2007-02-27 | 2008-09-03 | Certmedica International GmbH | Aqueous disinfectant gel preparation |
| JP2010047554A (en) * | 2008-08-25 | 2010-03-04 | Niitaka:Kk | Alcohol gel disinfectant composition |
| JP2011173823A (en) * | 2010-02-24 | 2011-09-08 | Hisamitsu Pharmaceut Co Inc | Gel preparation |
| WO2017077872A1 (en) * | 2015-11-05 | 2017-05-11 | エステー株式会社 | Alcohol-based gel composition and method for producing same |
| CN111264558A (en) * | 2020-04-07 | 2020-06-12 | 河南省奥林特药业有限公司 | Wash-free gel disinfectant for inhibiting ethanol volatilization and preparation process thereof |
| CN111714424A (en) * | 2020-08-07 | 2020-09-29 | 泰州市榕兴医疗用品股份有限公司 | Hand-washing-free disinfection gel |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113244322A (en) * | 2021-05-06 | 2021-08-13 | 常州美康源医疗科技有限公司 | Hand-washing-free disinfectant |
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Application publication date: 20210305 |
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