CN112237604A

CN112237604A - Traditional Chinese medicine incense for reducing epidemic infection and preparation process thereof

Info

Publication number: CN112237604A
Application number: CN202011046503.4A
Authority: CN
Inventors: 管咏梅; 万强; 熊俊; 陈浩; 张琦
Original assignee: Jiangxi University of Traditional Chinese Medicine
Current assignee: Jiangxi University of Traditional Chinese Medicine
Priority date: 2020-09-29
Filing date: 2020-09-29
Publication date: 2021-01-19

Abstract

The invention relates to a traditional Chinese medicine incense for reducing epidemic disease infection, which is prepared from the following medicinal materials in parts by mass: 15-30% of cypress powder, 1-3% of additional material and the balance of aromatic medicine; the aromatic medicine is prepared from folium Artemisiae Argyi, rhizoma Atractylodis, spina Gleditsiae, herba Agastaches, herba Menthae, herba Moslae, radix Acanthopanacis Senticosi, folium Polygoni Tinctorii, calendula flower, rhizoma Acori Graminei and lignum Aquilariae Resinatum. The incense has the effects of expelling wind and removing cold and dampness, resolving dampness and regulating the middle warmer, inducing sweat and relieving exterior syndrome, tonifying qi and strengthening spleen, inducing resuscitation and eliminating phlegm, resolving dampness and stimulating appetite, promoting qi circulation and relieving pain and warming middle warmer and arresting vomiting, detoxifying and killing insects and the like, and can reduce the risk of people infected by epidemic diseases by frequently using the incense at home. The invention also relates to a preparation method of the traditional Chinese medicine incense, the preparation method prepares superfine powder, volatile oil and extract powder, the volatile oil and additional materials are mixed to prepare additional material liquid, the incense medicine powder dough is placed in a sealed tank for sealed fermentation, and the permeability of the additional material liquid in the fermented incense medicine powder dough is increased by spraying the additional material liquid for multiple times, so that the traditional Chinese medicine incense is finally prepared.

Description

Traditional Chinese medicine incense for reducing epidemic infection and preparation process thereof

Technical Field

The invention relates to the technical field of medicinal incense, in particular to a traditional Chinese medicine medicinal incense for reducing epidemic infection and a preparation process thereof.

Background

Epidemic infection is a respiratory disease with strong infectivity, and clinical early symptoms can also be other manifestations besides fever, cough and hypodynamia, including diarrhea, vomiting, rash, conjunctivitis, dizziness, pain and the like, while fever is the primary symptom of treatment.

For the Chinese medicine understanding of the disease, experts generally think that the disease firstly belongs to the category of epidemic disease of the Chinese medicine in view of the epidemic and infectivity of the disease; this is called as exogenous pathogenic qi in TCM. The epidemic situation has the characteristic that the epidemic toxin is mixed with dry qi and damp-cold pathogen to cause damp-cold epidemic due to the combination of the occurrence time of the epidemic situation, the disease is located in the lung because of the feeling of the qi of the pestilence, the pathogenesis is characterized by 'damp, toxin, heat and deficiency', the damp toxin attacks the lung, the weak spleen and stomach and yang qi are susceptible, the qi of the pestilence is easy to be transmitted and changed, the early symptoms are complicated and changeable, and the temporary symptoms are always considered to be treated from the damp pathogen.

For ordinary people, the prevention, control and treatment of epidemic infection are difficult. The symptomatic treatment and preventive intervention are mainly performed. The effect is not good in clinical use due to lack of proper specific drugs. The common antiviral chemical drugs have the problems of drug resistance, adverse reaction, high price and the like. In contrast, the traditional Chinese medicine has a unique theoretical system, abundant clinical experience, individualized clinical prescription and definite curative effect. The traditional Chinese medicine for treating epidemic infection has obvious advantages in the aspects of early intervention, blocking the course of disease, relieving symptoms, shortening the treatment time, relieving complications, relieving toxic and side effects caused by large dose of hormone and the like, and can play an active role in the whole course of epidemic prevention and treatment. The treatment scheme comprises aromatherapy, and aims to enhance the physique of people, improve the immunity of organisms and effectively prevent the spread and the pandemics of diseases.

The traditional Chinese medicine aromatherapy utilizes special aromatic traditional Chinese medicines, plays an important role in the aspects of aromatic epidemic prevention and dirt avoidance, has the characteristics of accuracy, uniqueness, quick effect and naturalness, has the advantages that the aroma is really small molecular substances which are diffused in the air and enter the human body through inhalation, skin, oral cavity and other ways so as to balance yin and yang, regulate qi and blood and form spirit to be nourished together, plays a main role in treating diseases, plays a synergistic effect in treating serious diseases and a core role in health preservation and rehabilitation, and has unique advantages for preventing and treating respiratory tract susceptibility virus diseases. The treatment of the aromatherapy is to utilize the aromatic smell and the healing capacity of the pure natural medicines, and the medicines are absorbed by olfactory organs or skin of a person and act through nerves and a circulatory system, so that the body, the mind and the spirit of the person are balanced and unified. The fragrance can be absorbed through human skin or mouth and nose due to the characteristics of easy penetration, high fluidity and high absorbability, thereby achieving the effect of being absorbed by human body. The invention aims to provide a traditional Chinese medicine incense capable of reducing epidemic infection.

Disclosure of Invention

Technical problem to be solved

In order to solve the problems in the prior art, the invention provides a traditional Chinese medicine incense for reducing epidemic disease infection, which has the effects of expelling wind, clearing away cold and removing dampness, resolving dampness and regulating the middle warmer, inducing sweat, relieving exterior syndrome, tonifying qi, invigorating spleen, inducing resuscitation, eliminating phlegm, resolving dampness, stimulating appetite, promoting qi circulation, relieving pain, warming middle warmer, arresting vomiting, detoxifying, killing insects and the like, thereby reducing the risk of people infected by epidemic disease.

(II) technical scheme

In order to achieve the purpose, the invention adopts the main technical scheme that:

on one hand, the invention provides a traditional Chinese medicine incense for reducing epidemic disease infection, which is prepared from the following medicinal materials in parts by weight: 15-30% of cypress powder, 1-3% of additional materials and the balance of aromatic drugs;

the dosage ratio of the raw materials in the aromatic medicine is as follows: 5-10 parts of wormwood, 6-9 parts of rhizoma atractylodis, 5-10 parts of spina gleditsiae, 5-8 parts of agastache rugosus, 3-6 parts of mint, 5-10 parts of elsholtzia, 20-27 parts of acanthopanax, 10-15 parts of folium polygoni tinctorii, 5-10 parts of calendula officinalis, 5-10 parts of rhizoma acori graminei and 3-5 parts of agilawood.

As a preferred embodiment of the present invention, wherein: the additional material comprises pericarpium Citri Tangerinae, Mel, and mother fungus bag; the mother fungus bag contains yeast, lactic acid bacteria, protease, amylase, lipase and cellulase. Preferably, the dried orange peel, the honey and the mother fungus bag are mixed according to the mass ratio of 0.2-0.5:1-2: 1-2.

As a preferred embodiment of the present invention, wherein: the preparation process of the mother fungus bag comprises the following steps: mixing yeast, lactobacillus, protease, amylase, lipase and cellulase (at a mass ratio of 1-2:1-2:1:2:1: 1), adding a certain amount of starch, fermenting at constant temperature of 36-37 deg.C and relative humidity of 60-70% for 40-80 hr, and air drying. After fermentation treatment, a large amount of nutrient substances such as saccharides, amino acids and the like are generated, and the nutrient substances further nourish yeasts, lactic acid bacteria and the like, so that the yeasts and the lactic acid bacteria metabolize to generate various enzymes, and the enzymes keep the renewal and activity.

On the other hand, the invention also provides a preparation process of the traditional Chinese medicine incense for reducing epidemic disease infection, which comprises the following steps:

s1, preparing the following medicinal materials according to the formula and the dosage ratio:

weighing 5-10 parts of wormwood, 6-9 parts of rhizoma atractylodis, 5-10 parts of spina gleditsiae, 5-8 parts of agastache rugosus, 3-6 parts of mint, 5-10 parts of elsholtzia, 20-27 parts of acanthopanax, 10-15 parts of folium polygoni tinctorii, 5-10 parts of calendula officinalis, 5-10 parts of rhizoma acori graminei and 3-5 parts of agilawood;

s2, superfine grinding:

drying lignum Aquilariae Resinatum, rhizoma Atractylodis, herba Agastaches, a part of herba Menthae and folium Artemisiae Argyi, pulverizing into coarse powder, mixing, and micronizing to obtain superfine powder (with particle size below 10 μm);

s3, preparing mixed volatile oil and extract powder:

extracting volatile oil from the rest herba Menthae, herba Moslae, radix Acanthopanacis Senticosi, rhizoma Acori Graminei, calendula flower, and spina Gleditsiae respectively by pure steam extraction method with volatile oil intelligent extraction and collection separator, mixing to obtain mixed volatile oil; mixing the materials after extracting volatile oil with folium Polygoni Tinctorii, extracting with 55-65% ethanol, concentrating, drying, and pulverizing to obtain extract powder;

s4, mixing:

s41, mixing the superfine powder and the extract powder obtained in the step S2 by an equivalent incremental method, adding cypress powder by the same method, and mixing to obtain incense powder; then adding deionized water according to the weight ratio of the perfume powder to the water of 1 (1-2), and uniformly stirring to form perfume powder paste;

s42, preparing additional materials, wherein the additional materials comprise dried orange peel, honey and mother fungus bags; adding 8-12 times of deionized water with the mass of 35-37 ℃, 1-3% (w/w) tween-80 and 5-10% (w/w) absolute ethyl alcohol into the additional material, uniformly mixing, spraying the mixed volatile oil obtained in the step S3, and emulsifying to obtain additional material liquid;

s43, slowly spraying 1/5-1/3 mass of the additional material liquid into the spice powder paste obtained in the step S41, kneading and mixing the materials while adding the materials until the materials are uniformly mixed to obtain a spice powder dough;

s5, fermentation, namely, putting the powder mass of the anther obtained in the step S43 into a sealed tank, sealing the sealed tank by adopting medicated leaven paste, carrying out water bath at 36-37 ℃ for 1-3h, and then fermenting at 30-36 ℃ for 8-15 h; after fermentation, opening the sealed tank under an aseptic environment, injecting 1/5-1/3 of the additional material liquid, heating in a water bath at 36-37 ℃ for 1-3h, fermenting at 36-40 ℃ for 20-30h, opening the sealed tank under an aseptic environment again, injecting the rest additional material liquid, and fermenting at a constant temperature of 36-40 ℃ for 20-28 days under a constant humidity;

s6, forming, namely taking out the incense medicine powder dough after fermentation is finished, naturally airing for 2 days, crushing to obtain medicine incense powder, adding deionized water according to the weight ratio of the medicine incense powder to the water of 1 (0.5-1), uniformly mixing to obtain wet medicine incense powder in a state of no blocking when being inserted by hands and scattering when being discharged by hands, and putting the wet medicine incense powder into a material groove of an extruder to be extruded into strips to obtain incense strips;

s7, drying: the incense stick is dried by high voltage electric field to remove water to obtain the medicated incense. The medicinal incense should be sealed in a sealed bag for storage.

According to the preferred embodiment of the invention, in step S3, the medicinal materials after the volatile oil extraction are mixed with folium polygoni multiflori, 60% ethanol with 10 times of the mass is added for extraction, the ethanol is evaporated and recycled, the concentrated solution is concentrated, and the extract powder is obtained by microwave drying and crushing.

According to the preferred embodiment of the present invention, in step S2, 1/3-1/2 and 1/2-2/3 of the total amount of mint is used for extracting volatile oil in step S3. In step S3, the volatile oil is extracted according to different medicinal materials respectively and then mixed.

According to the preferred embodiment of the invention, in step S41, deionized water is added according to the weight ratio of the perfume powder to water of 1 (1-2), and the mixture is stirred for 20-30 minutes at 20-40 rpm, and then stirred uniformly to form the perfume powder paste.

According to the preferred embodiment of the present invention, in step S5, the powder mass of the aromatic drug obtained in step S43 is placed in a sealed jar, sealed with Massa Medicata Fermentata paste, heated in a water bath at 37 + -0.5 ℃ for 1.5-2.5h, and then fermented at 30-36 ℃ for 12h + -0.5; after fermentation, the additional material liquid with the mass of 1/5-1/3 is injected into a sealed tank under the aseptic environment, and then is heated in water bath at the temperature of 37 +/-0.5 ℃ for 2h and is fermented at the temperature of 37-40 ℃ for 24h +/-0.5; after fermentation, opening the sealed tank again in a sterile environment, injecting the rest additional material liquid, and fermenting at constant temperature of 36-40 deg.C and constant humidity for 24 days.

(III) advantageous effects

The invention has the beneficial effects that:

(1) in the traditional Chinese medicine incense formula, the wormwood dispels cold, removes dampness, disinfects and relieves itching; rhizoma Atractylodis dries dampness and invigorates spleen, dispels wind and dispels cold; spina Gleditsiae has repercussive, toxic materials clearing away, pus discharging, parasite killing, and scabies and leprosy treating effects. The agastache rugosus is fragrant and turns turbid; herba Menthae has effects of dispelling pathogenic wind and heat, sterilizing, killing parasite, refreshing mind, relieving sore throat, and promoting eruption; herba Moslae has effects of inducing sweat, relieving exterior syndrome, eliminating dampness and regulating stomach, and can be used for treating aversion to cold, fever, headache, anhidrosis, abdominal pain, vomiting and diarrhea. Radix Et rhizoma Acanthopanacis Senticosi has effects in invigorating qi, strengthening spleen, tonifying kidney, and tranquilizing mind; folium Polygoni Tinctorii has effects of clearing heat and detoxicating, cooling blood and resolving macula, and can be used for treating epidemic febrile disease with fever, macula and eruption. Calendula officinalis flowers dispel wind and clear heat, and clear away heat and toxic materials; rhizoma Acori Graminei has effects of inducing resuscitation, eliminating phlegm, eliminating dampness and promoting appetite; chen Xiang moves qi and relieves pain, warms middle energizer and stops vomiting; dried orange peel has the functions of regulating qi, strengthening spleen, eliminating dampness and resolving phlegm. The prescription of the invention can treat damp obstruction of middle energizer, abdominal distention, coma, epilepsy, sore, carbuncle and pyogenic infections. One of the functions of cypress powder is as drug perfume base material (combustible strip load material), on the other hand cypress has important medicinal value: firstly, the method comprises the following steps: anhui and Dinhun can improve insomnia and dreaminess, and its fragrance can increase blood oxygen content and make people be happy. One of the functions of the honey is that the honey is taken as an adhesive, so that the wet medicinal incense powder is easy to extrude into a compact strip shape, and the incense strip with stable quality and uniform strip shape is obtained; in addition, Mel also has nerve tension relieving effect.

(2) In the preparation process, the volatile oil is respectively extracted from mint, elsholtzia, acanthopanax, grassleaf sweelflag rhizome, calendula, Chinese honeylocust spine and the like, mixed volatile oil is obtained by mixing, and the mixed volatile oil is mixed with additional materials, so that fat-soluble ingredients in the additional materials can be extracted, and additional material liquid is obtained. After the agilawood, the rhizoma atractylodis, the agastache rugosus, a part of the mint and the wormwood are dried to a certain degree, ultrafine grinding is facilitated to obtain ultrafine powder, the finer powder is, the easier the agglomeration is when the agilawood, the rhizoma atractylodis, the agastache rugosus, the part of the mint and the wormwood are prepared into the incense powder paste and the incense powder agglomerate, the higher the viscosity is, the tighter the adhesion between the powder particles is, and the more convenient the incense stick with uniform and uniform strip can be extruded without defective surface. Spraying the additive liquid into the powder paste, and kneading to make pericarpium Citri Tangerinae oil, Mel, and mother fungus bag penetrate into the powder ball, and the Mel further plays the role of binder.

(3) In the preparation process, in the fermentation step, the sealed tank is opened under the aseptic environment for many times, additional material liquid is sprayed, and water bath treatment is carried out for 1-3 hours at 36-37 ℃, so that the tangerine peel oil, the mixed volatile oil and various thalli or enzymes in the mother fungus bag can penetrate into the fragrant medicine powder dough, and the thalli and enzymes (saccharomycetes, lactic acid bacteria, protease, amylase, lipase and cellulase) in the mother fungus bag can be activated under the environment to increase the biological activity.

In step S7, the incense stick is dried by high voltage electric field to remove water to obtain the medicated incense, and the high voltage electric field drying method has high speed, and can not cause loss of volatile components in the medicated incense, and decrease and waste of drug effect due to decomposition and oxidation of active components at high temperature.

(4) The fermentation step enables the various bacteria and enzymes in the mother fungus bag to exert their effects. The yeast, the lactic acid bacteria and the like can promote the effective components of the medicinal materials in the fragrant medicine powder dough to seep out, the protease, the amylase, the lipase and the cellulase can convert macromolecular substances in the medicinal materials into micromolecular substances, and the micromolecular substances have better volatility, so that the substances in the fragrant medicine have stronger volatility and are easy to volatilize into the air to be absorbed into the blood by the nasal cavity of a patient through the lung, and the effect of the fragrant medicine is further promoted to be exerted.

Drawings

FIG. 1 is a flow chart of the preparation process of the traditional Chinese medicine incense for reducing epidemic infection.

Detailed Description

For the purpose of better explaining the present invention and to facilitate understanding, the present invention will be described in detail by way of specific embodiments with reference to the accompanying drawings.

The invention provides a traditional Chinese medicine incense for reducing epidemic disease infection, which is prepared from the following medicinal materials in parts by weight: 15-30% of cypress powder, 1-3% of additional materials and the balance of aromatic drugs; the dosage ratio of each raw material in the aromatic medicine is as follows: 5-10 parts of wormwood, 6-9 parts of rhizoma atractylodis, 5-10 parts of spina gleditsiae, 5-8 parts of agastache rugosus, 3-6 parts of mint, 5-10 parts of elsholtzia, 20-27 parts of acanthopanax, 10-15 parts of folium polygoni tinctorii, 5-10 parts of calendula officinalis, 5-10 parts of rhizoma acori graminei and 3-5 parts of agilawood.

Wherein the additional material comprises pericarpium Citri Tangerinae, Mel, and mother fungus bag; the mother fungus bag contains yeast, lactobacillus, protease, amylase, lipase and cellulase. Preferably, the dried orange peel, the honey and the mother fungus bag are mixed according to the mass ratio of 0.2-0.5:1-2: 1-2.

The preparation process of the mother fungus bag comprises the following steps: mixing yeast, lactobacillus, protease, amylase, lipase and cellulase (at a mass ratio of 1-2:1-2:1:2:1: 1), adding a certain amount of starch, fermenting at constant temperature of 36-37 deg.C and constant humidity of 60-70% for 40-80 hr, and air drying. After fermentation treatment, a large amount of nutrient substances such as saccharides, amino acids and the like are generated, and the nutrient substances further nourish yeasts, lactic acid bacteria and the like, so that the yeasts and the lactic acid bacteria metabolize to generate various enzymes, and the enzymes keep updating and activity.

In the traditional Chinese medicine incense formula, the wormwood dispels cold, removes dampness, disinfects and relieves itching; rhizoma Atractylodis can eliminate dampness, strengthen spleen, dispel wind and dispel cold; spina Gleditsiae has repercussive, toxic materials clearing away, pus discharging, parasite killing, and scabies and leprosy treating effects. Herba Agastaches is fragrant and turbid-removing; herba Menthae has effects of dispelling pathogenic wind and heat, sterilizing, killing parasite, refreshing mind, relieving sore throat, and promoting eruption; herba Moslae can relieve exterior syndrome by inducing sweat, and eliminate dampness and regulate the middle warmer, and can be used for treating aversion to cold, fever, headache, anhidrosis, abdominal pain, vomiting and diarrhea. Acanthopanax root, radix acanthopanacis senticosi has the effects of tonifying qi, strengthening spleen, tonifying kidney and soothing nerves; folium Polygoni Tinctorii has effects of clearing heat and detoxicating, cooling blood and resolving macula, and can be used for treating epidemic febrile disease fever, and macula and eruption. Calendula officinalis flowers dispel wind and clear heat, and clear away heat and toxic materials; rhizoma Acori Graminei has effects of inducing resuscitation, eliminating phlegm, eliminating dampness and promoting appetite; chen Xiang moves qi and relieves pain, warms middle energizer and stops vomiting; dried orange peel has the functions of regulating qi, strengthening spleen, eliminating dampness and resolving phlegm. The composition can treat damp obstruction of middle energizer, abdominal distention, coma, epilepsy, sore, carbuncle and pyogenic infections. One of the functions of cypress powder is as drug perfume base material (combustible strip load material), on the other hand cypress has important medicinal value: firstly, the method comprises the following steps: anhui and Dinhun can improve insomnia and dreaminess, and its fragrance can increase blood oxygen content and make people be delightful. One of the functions of the honey is that the honey is used as an adhesive, so that the wet medicinal incense powder is easy to extrude into a dense strip shape, and the incense strip with stable quality and uniform strip shape is obtained; in addition, Mel also has effect of relieving nervous tension.

The origin of the medicinal materials: mugwort is produced in Liaoning, atractylodes is produced in Jiangsu, Chinese honeylocust spine is produced in Henan, wrinkled gianthyssop is produced in Guangdong, mint is produced in Jiangsu, elsholtzia is produced in Jiangxi, acanthopanax is produced in Liaoning, dyers woad leaf is produced in Hebei, calendula is produced in Shandong, acorus gramineus is produced in Jiangxi, and agilawood is produced in Guangdong.

As shown in figure 1, the preparation process of the traditional Chinese medicine incense for reducing epidemic disease infection comprises the following steps:

s1 preparing the medicinal materials according to the formula and dosage ratio

Weighing 5-10 parts of wormwood, 6-9 parts of rhizoma atractylodis, 5-10 parts of spina gleditsiae, 5-8 parts of agastache rugosus, 3-6 parts of mint, 5-10 parts of elsholtzia, 20-27 parts of acanthopanax, 10-15 parts of folium polygoni tinctorii, 5-10 parts of calendula officinalis, 5-10 parts of rhizoma acori graminei and 3-5 parts of agilawood. Preparing cypress powder, dried orange peel, honey and mother fungus bags according to the proportion; the total mass of the dried orange peel, the honey and the mother fungus bag is 1/5-1/10 of the total mass of the cypress powder.

S2 superfine grinding

Drying lignum Aquilariae Resinatum, rhizoma Atractylodis, herba Agastaches, a part of herba Menthae and folium Artemisiae Argyi, pulverizing into coarse powder, mixing, and micronizing to obtain superfine powder (with particle size below 10 μm).

S3, preparing mixed volatile oil and extract powder:

extracting volatile oil from the rest herba Menthae, herba Moslae, radix Acanthopanacis Senticosi, rhizoma Acori Graminei, calendula flower, and spina Gleditsiae respectively by pure steam extraction method with volatile oil intelligent extraction and collection separator, mixing to obtain mixed volatile oil; mixing the materials after the volatile oil extraction with the folium polygoni tinctorii, adding 60% ethanol with the mass of 10 times of the materials for extraction, evaporating and recovering the ethanol, concentrating, drying by adopting microwave, and crushing to obtain extract powder.

S4, mixing:

s41, mixing the superfine powder and the extract powder obtained in the step S2 by an equivalent incremental method, adding cypress powder by the same method, and mixing to obtain incense powder; and then deionized water is added according to the weight ratio of the fragrant powder to the water of 1 (1-2), and the mixture is stirred for 20-30 minutes at 20-40 revolutions per minute, and is uniformly stirred to form fragrant powder paste.

S42, preparing additional materials, wherein the additional materials comprise rose petals, honey and a mother fungus bag; adding 8-12 times of 35-37 deg.C deionized water, 1-3% (w/w) Tween-80, and 5-10% (w/w) anhydrous ethanol into the additional material, mixing, spraying the mixed volatile oil obtained in step S3, and emulsifying to obtain additional material solution.

s5, fermentation, namely, putting the powder mass of the anther obtained in the step S43 into a sealed tank, sealing the sealed tank by adopting medicated leaven paste, carrying out water bath at 36-37 ℃ for 1-3h, and then fermenting at 30-36 ℃ for 8-15 h; after fermentation, opening the sealed tank under an aseptic environment, injecting 1/5-1/3 of the additional material liquid, heating in a water bath at 36-37 ℃ for 1-3h, fermenting at 36-40 ℃ for 20-30h, opening the sealed tank under an aseptic environment again, injecting the rest additional material liquid, and fermenting at a constant temperature of 36-40 ℃ for 20-28 days under a constant humidity.

And S6, forming, namely taking out the incense medicine powder dough after fermentation is finished, naturally airing for 2 days, crushing to obtain medicine incense powder, adding deionized water according to the weight ratio of the medicine incense powder to the water of 1 (0.5-1), uniformly mixing to obtain wet medicine incense powder in a state of being free of blocking when being inserted by hands and being scattered when being taken out by hands, and putting the wet medicine incense powder into a material groove of an extruder to be extruded into strips to obtain incense strips.

The following are preferred embodiments of the present invention.

(1) Dispensing: 246g of cypress powder, 7.4g of dried orange peel, 15g of honey, 15g of mother fungus bag, 30 g of agilawood, 30 g of mint, 80 g of wrinkled gianthyssop herb, 60 g of rhizoma atractylodis, 50 g of wormwood, 50 g of spina gleditsiae, 100 g of elsholtzia, 100 g of calendula flower, 100 g of rhizoma acori graminei, 150 g of folium polygoni tinctorii and 200 g of acanthopanax.

(2) Superfine grinding: drying the agilawood, the rhizoma atractylodis, the agastache rugosus, the 15g of mint and the wormwood in the step (1), crushing into coarse powder, uniformly mixing, and carrying out superfine grinding to obtain superfine powder;

(3) extraction: firstly, extracting volatile oil one by one from 15g of mint, elsholtzia, acanthopanax, acorus gramineus, calendula and spina gleditsiae in the step (1) by using a pure steam extraction method of an intelligent volatile oil extraction and collection separator, and mixing to obtain mixed volatile oil; then adding the medicinal materials after extracting the volatile oil into the polygonum tinctorium leaves, adding 60 percent ethanol with the mass of 10 times of the polygonum tinctorium leaves for extraction, recovering the ethanol, concentrating, drying and crushing to obtain extract powder.

(4) Blending, comprising step A, B, C:

firstly, mixing the superfine powder obtained in the step (2) and the extract powder obtained in the step (3) by adopting an equivalent incremental method, and then adding cedar wood powder by adopting the same method for mixing to obtain incense powder; and then deionized water is added according to the weight ratio of the fragrant powder to the water of 1:1.4, and the mixture is stirred for 30 minutes at 40 revolutions per minute to obtain the medicine fragrant paste.

B. Mixing pericarpium Citri Tangerinae 7.4g, Mel 15g, and mother fungus bag 15g to obtain additional material. Adding 10 times of deionized water at 37 deg.C, 2% (w/w) Tween-80, and 10% (w/w) anhydrous ethanol into the additive material, mixing, spraying the extracted mixed volatile oil, and emulsifying to obtain additive material solution.

C. Slowly spraying 1/3 of the additional material liquid under item B into the medicinal incense paste under item A, and manually kneading and mixing while adding until uniformly mixing to obtain medicinal incense mass.

(5) Fermentation: and (3) placing the medicinal fragrant powder dough obtained in item C in item (4) in a sealed tank, sealing with medicated leaven mud, carrying out water bath at 37 ℃ for 2.5 hours, fermenting at 37 ℃ for 12 hours, opening a small opening of the sealed tank in a sterile room, injecting additional material liquid with the total amount of 1/3 by using an injector, heating at 37 ℃ for 2 hours after sealing, placing at 37 ℃ for 24 hours, opening the small opening in the sterile room again, injecting the rest additional material liquid by using the injector, sealing, and fermenting at constant temperature and constant humidity of 38.5 ℃ for 24 days.

(6) Forming, namely taking out the aroma medicine powder dough after fermentation is finished, naturally airing for 2 days, crushing to obtain medicine aroma powder, adding deionized water according to the weight ratio of the medicine aroma powder to the water of 1:0.6, uniformly mixing to obtain wet medicine aroma powder in a state of 'hand insertion without blocking and hand discharge dispersing', and putting the wet medicine aroma powder into a material groove of an extruder to extrude the wet medicine aroma powder into strips to obtain aroma strips;

(7) and (3) drying: removing water from the incense stick of item (6) by high voltage electric field drying method to obtain medicinal incense.

Clinical test of drug fragrance

1. General data:

210 cases meeting the inclusion standard of the traditional Chinese medicine cold are selected from the department of respiration, the red valley beach hospital and the Yangming road clinic of the affiliated hospital of the Jiangxi traditional Chinese medicine university from 3 months in 2019 to 12 months in 2019. 120 of 210 cold residents are selected as cold susceptible people groups in a questionnaire mode, and the cold susceptible people groups are divided into groups by a random digital table method, wherein one group is used as a epidemic-removing and dirt-avoiding intervention group 60 cases, and the other group is used as a blank control group (hereinafter referred to as a control group) 60 cases.

2. Diagnostic criteria:

the Western medicine diagnosis standard is compiled by Chen Hui Zhen Zhu, Utility internal sciences, 12 th edition, and people's health society. History of cold exposure to influenza; local symptoms are predominant, and systemic symptoms may be present or not apparent; local symptoms: nasal obstruction, spray claim, runny nose, cough, sore throat, gradual voice, and lacrimation. ② general symptoms: aversion to cold, fever, headache, dizziness, general malaise, soreness of the limbs and back. Blood picture: more normal or lower white blood cell counts. The diagnosis standard of Chinese medicine syndrome refers to the "clinical research guidelines for New drug of traditional Chinese medicine" first edition of 5 months in 2002 (the "common cold" is formulated in the "internal medicine of traditional Chinese medicine" 10 th edition)

Wind-cold type. The main symptoms are: severe aversion to cold, mild fever, no sweating, claim eruption, nasal obstruction, clear nasal discharge, headache, soreness and pain of limbs and joints, and superficial and tense pulse. The secondary symptoms are as follows: pharynx itch, the culm drive clears thin and white phlegm, thirst or thirst with desire for hot water, pale red tongue with thin and moist coating.

Wind-heat type. The main symptoms are: severe fever, slight aversion to wind, unsmooth sweating, swollen and sore throat, nasal obstruction, yellow and watery nasal discharge, and superficial and rapid pulse. The secondary symptoms are as follows: distending pain in the head, coughing, yellow sputum, thirst with desire for water, red tongue with thin or yellow coating.

Type of weak constitution. The main symptoms are: aversion to cold, fever, headache, dizziness, nasal obstruction, lassitude, weakness, spontaneous or night sweating, recurrent attacks, floating and weak pulse or thready and rapid pulse. The secondary symptoms are as follows: old age or weakness, a pale red tongue with thin white or red coating and little coating.

The disease grading standard is drawn up according to the clinical research guiding principle of new Chinese medicine in China pharmaceutical science and technology Press, 5-month, 1 st edition in 2002

Light: the integral is between 2 and 20 points;

the method comprises the following steps: the integral is between 21 and 40 points;

heavy: the integral is over 41 points.

3. Inclusion criteria

Age 18-70 years; the diagnosis standard of the traditional Chinese medicine cold and the upper respiratory tract infection of the western medicine is met; the patients with the common cold are susceptible, and the disease belongs to the patients with the non-acute upper respiratory tract infection; the vital signs are stable, the intelligence is clear, certain expression capacity is realized, and patients are informed to cooperate.

4. Exclusion criteria

Severe patients with typical influenza manifestations, with immediate systemic failure; other disease patients (tuberculosis, pneumonia, splenomegaly, etc.) who can cause fever; patients with serious primary diseases such as heart, cerebral vessels, liver, kidney, hemopoietic system and the like, and diabetes mellitus; pregnant or lactating women; allergic constitution or those allergic to the drug fragrance used in this study; patients with mental disease.

5. Intervention measures

The test group administered the herbal fragrance, and each person ignited one time per day (hung in front of chest in the daytime, away from nasal cavity, and placed on the edge of the pillow at night, and changed every day for 3 months). Control group blank. During the visit, two groups of patients were followed up by outpatient visits and phone tracking visits.

6. Observation index

Recording the number of cold attacks before and after treatment of the patient: the disease is not 0 grade, the average disease is less than 1 time per month and I grade, the average disease is 1-2 times per month and II grade, and the average disease is more than 2 times per month and III grade. Recording the disease course of the cold before and after the treatment of the patient: no incidence is 0 grade, each incidence is I grade in less than 5 days, each incidence is II grade in 5-10 days, and each incidence is III grade in more than 10 days.

7. Standard of therapeutic effect

According to the standard of the Chinese medicine industry of the people's republic of China, namely the standard of the curative effect of the diagnosis of the traditional Chinese medicine symptoms, the nimodipine method is adopted. Measure of the effective treatment for furuncle-score before treatment-score after treatment) score before treatment

The clinical cure is as follows: clinical symptoms disappeared, or the score improvement rate was at least 95%.

The effect is shown: the clinical symptoms mostly disappear, or the integral improvement rate is between 70% and 95%.

Improvement: the clinical symptoms are obviously improved, or the integral improvement rate is between 30% and 70%.

And (4) invalidation: no improvement or aggravation of clinical symptoms, or an integral improvement rate of less than 30%.

8. Statistical analysis

All analyses were counted by SPSS20.0 statistical software, and the measured data were expressed as mean ± standard deviation; performing interclass comparison by using two independent samples for t test; the samples in the group are tested by adopting pairing t; counting data are expressed by using numbers or percentages, and comparison among groups is checked by using X2; the grade data were analyzed by Ridit. P is less than or equal to 0.05 and is taken as having significance statistical significance, and P is less than or equal to 0.01 and is taken as having significance statistical significance.

Test results

1. Baseline data comparison

As shown in Table 1, the patients in the experimental group had a maximum age of 62 years, a minimum age of 18 years, and an average of 41.22. + -. 4.67 years. The patients in the control group had a maximum age of 63 years, a minimum age of 18 years, and an average of 42.20 ± 4.79 years. The mean ages of the two groups showed no statistical significance by t-test (P > 0.05). This indicates that the age of the patients in both groups is comparable.

TABLE 1 comparison of age distributions of two groups

As shown in Table 2, the patients in the test group had a longest course of disease of 10 years, a shortest course of disease of 2 years, and a mean course of disease of 7.90. + -. 4.11 years. The longest course of disease among the patients in the control group is 8 years, the shortest course of disease is 3 years, and the average course of disease is 8.10 +/-4.20 years. The mean disease course of the two groups showed no statistical significance by t-test (P > 0.05). This indicates that the disease course is comparable for both groups of patients.

TABLE 2 comparison of the two disease course distributions

As shown in table 3, this study included 62 cases in men and 58 cases in women. Table 3 shows that 31 males in the experimental group accounted for 53.33%; 29 women account for 48.33%. 30 male cases in the control group account for 50.00 percent; 30 women account for 50.00 percent. Jingchi type²Inspection, χ²＝0.220，P＝0.89>0.05. The two groups of patients had no statistical significance for sex (P)>0.05). This indicates that the two groups of patients are sex comparable.

TABLE 3 comparison of sex ratios (n,%)

Table 4 shows that 14 patients, 16 patients and 30 patients in the test group have grade I, 16 patients in the II and 31 patients in the control group have grade I, 18 patients in the II and 31 patients in the III, and the Ridit analysis of the grade data shows no statistical significance (P > 0.05). This indicates that the disease grading was comparable in both groups of patients.

TABLE 4 grading comparison of the conditions of two groups of patients (n)

2. Comparison after treatment

Table 5 shows that the curative effect of angina pectoris of the patients in the test group is 23 cases, 34 cases and 3 cases. The control group patients had 15 cases with significant angina pectoris curative effect, 19 cases with effective angina pectoris curative effect and 16 cases with ineffective angina pectoris curative effect. Ridit analysis using grade data shows statistical significance (P < 0.05). This indicates that the test group is superior in clinical efficacy compared to the control group.

TABLE 5 comparison of the two groups of clinical effects (n)

In the test process, 1 case of the test group has adverse reaction, namely pruritus, and the adverse reaction is relieved automatically in 1 day. Adverse reactions occurred in 0 cases of control group. The two groups of patients were subjected to routine examination of blood, urine and stool before and after treatment, and liver and kidney function examination and electrocardiographic examination to evaluate the safety of the medicine. As a result: no normal condition before treatment is found, and abnormal results after treatment indicate that the medicine is safe.

Claims

1. The traditional Chinese medicine incense for reducing epidemic disease infection is characterized by being prepared from the following medicinal materials in parts by mass: 15-30% of cypress powder, 1-3% of additional materials and the balance of aromatic drugs;

2. The traditional Chinese medicine incense for reducing epidemic infection according to claim 1, wherein the additional material comprises pericarpium Citri Reticulatae, Mel, and mother fungus bag; the mother fungus bag contains yeast, lactobacillus, protease, amylase, lipase and cellulase.

3. The traditional Chinese medicine incense for reducing epidemic infection according to claim 3, wherein the dried orange peel, the honey and the mother fungus bag are mixed according to the mass ratio of 0.2-0.5:1-2: 1-2.

4. The traditional Chinese medicine incense for reducing epidemic infection according to claim 3 or 4, wherein the preparation process of the mother fungus bag comprises the following steps: mixing yeast, lactobacillus, protease, amylase, lipase and cellulase, adding a certain amount of starch, fermenting at constant temperature of 36-37 deg.C and constant humidity of 60-70% for 40-80 hr, and air drying.

5. A preparation process of a traditional Chinese medicine incense for reducing epidemic disease infection is characterized by comprising the following steps:

s2, superfine grinding:

s3, preparing mixed volatile oil and extract powder:

extracting the rest herba Menthae, herba Moslae, radix Acanthopanacis Senticosi, rhizoma Acori Graminei, calendula flower, and spina Gleditsiae with volatile oil by intelligent extraction separator, and mixing to obtain mixed volatile oil; mixing the materials after extracting volatile oil with folium Polygoni Tinctorii, extracting with 55-65% ethanol, concentrating, drying, and pulverizing to obtain extract powder;

s4, mixing:

s42, preparing additional materials, wherein the additional materials comprise dried orange peel, honey and mother fungus bags; adding 8-12 times of deionized water with the mass of 35-37 ℃, 1-3% (w/w) Tween 80 and 5-10% (w/w) of absolute ethyl alcohol into the additional material, uniformly mixing, spraying the mixed volatile oil obtained in the step S3, and emulsifying to obtain additional material liquid;

s5, fermentation, namely, putting the powder mass of the anther obtained in the step S43 into a sealed tank, sealing the sealed tank by adopting medicated leaven paste, carrying out water bath at 36-37 ℃ for 1-3h, and then fermenting at 30-36 ℃ for 8-15 h; after fermentation, opening the sealed tank in a sterile environment, injecting 1/5-1/3 of the additional material liquid, heating in a water bath at 36-37 ℃ for 1-3h, fermenting at 36-40 ℃ for 20-30h, opening the sealed tank in a sterile environment again, injecting the rest additional material liquid, and fermenting at a constant temperature of 36-40 ℃ for 20-28 days under a constant humidity;

s6, forming, namely taking out the incense powder dough after fermentation is finished, naturally airing for 2 days, crushing to obtain medicine incense powder, adding deionized water according to the weight ratio of the medicine incense powder to the water of 1 (0.5-1), uniformly mixing to obtain wet medicine incense powder in a state of being inserted by hands without blocking and being scattered when being discharged by hands, and putting the wet medicine incense powder into a material groove of an extruder to be extruded into strips to obtain incense strips;

s7, drying: the incense stick is dried by high voltage electric field to remove water to obtain the medicated incense.

6. The preparation process according to claim 5, wherein in step S3, the medicinal materials after the volatile oil extraction are mixed with folium polygoni tinctorii, 10 times of 60% ethanol by mass is added for extraction, ethanol is recovered by evaporation, the concentration is carried out, microwave drying is adopted, and the extract powder is obtained by crushing.

7. The preparation process of claim 5, wherein in step S2, the mint is used in the step S3 to extract volatile oil, wherein 1/3-1/2 and 1/2-2/3 of the total amount of mint are used; in step S3, the volatile oil is extracted from different medicinal materials respectively and then mixed.

8. The preparation process of claim 5, wherein in step S41, deionized water is added according to the weight ratio of the perfume powder to water of 1 (1-2), and the mixture is stirred at 20-40 rpm for 20-30 min and then uniformly stirred to form perfume powder paste.

9. The process according to claim 5, wherein in step S5, the powdered mass of the fragrance medicine obtained in step S43 is placed in a sealed can, sealed with Massa Medicata Fermentata paste, heated in a water bath at 37 ± 0.5 ℃ for 1.5-2.5h, and then fermented at 30-36 ℃ for 12h ± 0.5; after fermentation, the additional material liquid with the mass of 1/5-1/3 is injected into a sealed tank under the aseptic environment, and then is heated in water bath at the temperature of 37 +/-0.5 ℃ for 2h and is fermented at the temperature of 37-40 ℃ for 24h +/-0.5; after fermentation, opening the sealed tank again in a sterile environment, injecting the rest additional material liquid, and fermenting at constant temperature of 36-40 deg.C and constant humidity for 24 days.