CN112005110A - 一种达肝素钠亚硝酸降解产物的分析方法及其应用 - Google Patents
一种达肝素钠亚硝酸降解产物的分析方法及其应用 Download PDFInfo
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- CN112005110A CN112005110A CN201980027376.2A CN201980027376A CN112005110A CN 112005110 A CN112005110 A CN 112005110A CN 201980027376 A CN201980027376 A CN 201980027376A CN 112005110 A CN112005110 A CN 112005110A
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- sodium
- dalteparin sodium
- nitrous acid
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- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
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Abstract
一种达肝素钠亚硝酸降解产物的分析方法，所述方法包括：将所述低分子肝素用亚硝酸完全降解得到降解产物，以及将所述降解产物经高效液相色谱(HPLC)联用电雾式检测器(CAD)进行检测。此方法无需衍生和脱乙酰步骤，降解产物制备时间短、分析成本低、检测准确率高。
Description
PCT国内申请，说明书已公开。
Claims (10)
- PCT国内申请，权利要求书已公开。
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| JP7415771B2 (ja) | 2020-04-24 | 2024-01-17 | 株式会社島津製作所 | 分析支援装置、分析支援方法および分析支援プログラム |
| CN114371250B (zh) * | 2022-01-25 | 2024-05-14 | 武汉九州钰民医药科技有限公司 | 一种奥扎格雷钠原料药中乙酸盐的测定方法 |
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| EP1580197A1 (en) * | 2004-03-24 | 2005-09-28 | Aventis Pharma S.A. | Method for quantitatively determining specific groups constituting heparins or low molecular wieght heparins using HPLC |
| CN103675144B (zh) * | 2013-12-12 | 2015-06-17 | 中国海洋大学 | 一种化学降解肝素及检测肝素二糖组成的方法 |
| CN108107138A (zh) * | 2017-12-18 | 2018-06-01 | 广西壮族自治区梧州食品药品检验所 | Hplc-cad测定葡萄糖氯化钠注射液中葡萄糖的方法 |
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2019
- 2019-07-23 WO PCT/CN2019/097283 patent/WO2020020152A1/zh active Application Filing
- 2019-07-23 CN CN202310030098.4A patent/CN116879411A/zh active Pending
- 2019-07-23 CN CN201980027376.2A patent/CN112005110B/zh active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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