CN111701077A - 一种具有抗血栓抗钙化功能的瓣膜及其制备方法和应用 - Google Patents
一种具有抗血栓抗钙化功能的瓣膜及其制备方法和应用 Download PDFInfo
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- CN111701077A CN111701077A CN202010587270.2A CN202010587270A CN111701077A CN 111701077 A CN111701077 A CN 111701077A CN 202010587270 A CN202010587270 A CN 202010587270A CN 111701077 A CN111701077 A CN 111701077A
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- valve
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- anticalcification
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- 239000003146 anticoagulant agent Substances 0.000 title claims abstract description 18
- 230000002785 anti-thrombosis Effects 0.000 title claims abstract description 14
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- 208000007536 Thrombosis Diseases 0.000 claims abstract description 24
- 229920000642 polymer Polymers 0.000 claims abstract description 24
- 230000002308 calcification Effects 0.000 claims abstract description 22
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 claims abstract description 14
- 238000002791 soaking Methods 0.000 claims abstract description 10
- 239000003638 chemical reducing agent Substances 0.000 claims abstract description 7
- 238000006243 chemical reaction Methods 0.000 claims abstract description 4
- 239000000243 solution Substances 0.000 claims description 14
- 239000000758 substrate Substances 0.000 claims description 6
- 210000003709 heart valve Anatomy 0.000 claims description 5
- 239000007853 buffer solution Substances 0.000 claims description 4
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims description 4
- 239000008367 deionised water Substances 0.000 claims description 3
- 229910021641 deionized water Inorganic materials 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims description 2
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 claims description 2
- 229920001577 copolymer Polymers 0.000 claims description 2
- 235000019253 formic acid Nutrition 0.000 claims description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- 150000003141 primary amines Chemical class 0.000 claims description 2
- 125000000467 secondary amino group Chemical class [H]N([*:1])[*:2] 0.000 claims description 2
- 239000012279 sodium borohydride Substances 0.000 claims description 2
- 229910000033 sodium borohydride Inorganic materials 0.000 claims description 2
- BEOOHQFXGBMRKU-UHFFFAOYSA-N sodium cyanoborohydride Chemical compound [Na+].[B-]C#N BEOOHQFXGBMRKU-UHFFFAOYSA-N 0.000 claims description 2
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims description 2
- 238000000034 method Methods 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000463 material Substances 0.000 abstract description 20
- 125000003172 aldehyde group Chemical group 0.000 abstract description 6
- 230000002035 prolonged effect Effects 0.000 abstract description 3
- 208000032843 Hemorrhage Diseases 0.000 abstract description 2
- 230000000702 anti-platelet effect Effects 0.000 abstract description 2
- 229940127219 anticoagulant drug Drugs 0.000 abstract description 2
- 208000034158 bleeding Diseases 0.000 abstract description 2
- 230000000740 bleeding effect Effects 0.000 abstract description 2
- 239000003814 drug Substances 0.000 abstract description 2
- 230000007774 longterm Effects 0.000 abstract description 2
- 230000000630 rising effect Effects 0.000 abstract description 2
- 230000008719 thickening Effects 0.000 abstract description 2
- 210000001519 tissue Anatomy 0.000 description 7
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 3
- 239000011575 calcium Substances 0.000 description 3
- 229910052791 calcium Inorganic materials 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 238000004132 cross linking Methods 0.000 description 3
- 238000002513 implantation Methods 0.000 description 3
- 150000002500 ions Chemical class 0.000 description 3
- 210000003516 pericardium Anatomy 0.000 description 3
- 238000001179 sorption measurement Methods 0.000 description 3
- 230000002429 anti-coagulating effect Effects 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000008520 organization Effects 0.000 description 2
- 210000003102 pulmonary valve Anatomy 0.000 description 2
- 102000015081 Blood Coagulation Factors Human genes 0.000 description 1
- 108010039209 Blood Coagulation Factors Proteins 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 102000003855 L-lactate dehydrogenase Human genes 0.000 description 1
- 108700023483 L-lactate dehydrogenases Proteins 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 239000002262 Schiff base Substances 0.000 description 1
- 150000004753 Schiff bases Chemical class 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 125000003368 amide group Chemical group 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000003114 blood coagulation factor Substances 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000004 hemodynamic effect Effects 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 210000004623 platelet-rich plasma Anatomy 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3625—Vascular tissue, e.g. heart valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/0005—Use of materials characterised by their function or physical properties
- A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
- A61L33/0023—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using a quaternized group or a protonated amine group of the substrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/0005—Use of materials characterised by their function or physical properties
- A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
- A61L33/0041—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate characterised by the choice of an antithrombatic agent other than heparin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/06—Use of macromolecular materials
- A61L33/064—Use of macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/20—Materials or treatment for tissue regeneration for reconstruction of the heart, e.g. heart valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/40—Preparation and treatment of biological tissue for implantation, e.g. decellularisation, cross-linking
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Materials Engineering (AREA)
- Surgery (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Botany (AREA)
- Materials For Medical Uses (AREA)
Abstract
Description
组织名称 | 吸附量 |
AMA-MPC | 0.5±0.3 |
AMA-SBMA | 0.2±0.2 |
AMA-CBMA | 0.4±0.2 |
戊二醛交联生物瓣膜 | 1.2±0.1 |
组织名称 | 钙含量(g/kg) |
AMA-MPC | 14.9 |
AMA-SBMA | 15.2 |
AMA-CBMA | 15.5 |
戊二醛交联生物瓣膜 | 120.6 |
Claims (10)
Priority Applications (1)
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CN202010587270.2A CN111701077B (zh) | 2020-06-24 | 2020-06-24 | 一种具有抗血栓抗钙化功能的瓣膜及其制备方法和应用 |
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CN202010587270.2A CN111701077B (zh) | 2020-06-24 | 2020-06-24 | 一种具有抗血栓抗钙化功能的瓣膜及其制备方法和应用 |
Publications (2)
Publication Number | Publication Date |
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CN111701077A true CN111701077A (zh) | 2020-09-25 |
CN111701077B CN111701077B (zh) | 2021-05-11 |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113082292A (zh) * | 2021-03-02 | 2021-07-09 | 四川大学华西医院 | 一种两性离子聚合物修饰的生物瓣膜材料及其制备方法 |
CN113101412A (zh) * | 2021-03-02 | 2021-07-13 | 四川大学华西医院 | 一种长效稳定的抗凝生物瓣膜材料及其制备方法 |
CN113476659A (zh) * | 2021-05-31 | 2021-10-08 | 四川大学 | 一种人工生物瓣膜处理方法 |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0103946A2 (en) * | 1982-08-25 | 1984-03-28 | McNeilab, Inc. | Method for inhibiting mineralization of natural tissue during implantation |
CN1775313A (zh) * | 2005-10-14 | 2006-05-24 | 浙江大学 | 改善生物医用材料生物相容性的聚合物刷及其制备方法 |
CN101429287A (zh) * | 2008-11-28 | 2009-05-13 | 南京大学 | 一种高抗凝血纤维素膜材料及其制备方法 |
CN102000359A (zh) * | 2010-12-15 | 2011-04-06 | 西南交通大学 | 一种钛基材料表面接枝2-甲基丙烯酰氧乙基磷酸胆碱聚合物的方法 |
CN102803350A (zh) * | 2009-06-15 | 2012-11-28 | 帝斯曼知识产权资产管理有限公司 | 用于医疗应用的磷酸胆碱基两亲性硅酮 |
CN103705980A (zh) * | 2007-12-21 | 2014-04-09 | 爱德华兹生命科学公司 | 加帽生物假体组织以减少钙化 |
CN105744967A (zh) * | 2013-11-28 | 2016-07-06 | 东丽株式会社 | 抗血栓性材料 |
-
2020
- 2020-06-24 CN CN202010587270.2A patent/CN111701077B/zh active Active
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0103946A2 (en) * | 1982-08-25 | 1984-03-28 | McNeilab, Inc. | Method for inhibiting mineralization of natural tissue during implantation |
CN1775313A (zh) * | 2005-10-14 | 2006-05-24 | 浙江大学 | 改善生物医用材料生物相容性的聚合物刷及其制备方法 |
CN103705980A (zh) * | 2007-12-21 | 2014-04-09 | 爱德华兹生命科学公司 | 加帽生物假体组织以减少钙化 |
CN101429287A (zh) * | 2008-11-28 | 2009-05-13 | 南京大学 | 一种高抗凝血纤维素膜材料及其制备方法 |
CN102803350A (zh) * | 2009-06-15 | 2012-11-28 | 帝斯曼知识产权资产管理有限公司 | 用于医疗应用的磷酸胆碱基两亲性硅酮 |
CN102000359A (zh) * | 2010-12-15 | 2011-04-06 | 西南交通大学 | 一种钛基材料表面接枝2-甲基丙烯酰氧乙基磷酸胆碱聚合物的方法 |
CN105744967A (zh) * | 2013-11-28 | 2016-07-06 | 东丽株式会社 | 抗血栓性材料 |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113082292A (zh) * | 2021-03-02 | 2021-07-09 | 四川大学华西医院 | 一种两性离子聚合物修饰的生物瓣膜材料及其制备方法 |
CN113101412A (zh) * | 2021-03-02 | 2021-07-13 | 四川大学华西医院 | 一种长效稳定的抗凝生物瓣膜材料及其制备方法 |
CN113476659A (zh) * | 2021-05-31 | 2021-10-08 | 四川大学 | 一种人工生物瓣膜处理方法 |
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