CN111514231A - Application of ephedra and apricot lung-ventilating traditional Chinese medicine composition as influenza virus treatment medicine - Google Patents
Application of ephedra and apricot lung-ventilating traditional Chinese medicine composition as influenza virus treatment medicine Download PDFInfo
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Abstract
The invention discloses an application of a ephedra and apricot lung-ventilating traditional Chinese medicine composition as an influenza virus treatment medicine, wherein the ephedra and apricot lung-ventilating traditional Chinese medicine composition is applied to treating influenza virus infection fever and viral respiratory inflammation; the lung-ventilating ephedra and apricot kernel traditional Chinese medicine composition is prepared from ephedra, semen armeniacae amarae (blanched), liquorice, platycodon grandiflorum, thunberg fritillary bulb, houttuynia cordata, lonicera confusa and dried orange peel. The ephedra and apricot lung-ventilating traditional Chinese medicine composition disclosed by the invention finds a new medical application, is applied to treating influenza virus infection fever and viral respiratory inflammation, and can effectively relieve symptoms of the influenza virus infection fever and the viral respiratory inflammation and cure the influenza virus infection fever and the viral respiratory inflammation.
Description
Technical Field
The invention relates to an influenza virus treatment drug, in particular to application of a ephedra and apricot lung-ventilating traditional Chinese medicine composition as an influenza virus treatment drug.
Background
Influenza virus (inflenzavirus) is an important disease affecting human health and economic development in the 21 st century, and has increasingly negative impact on various countries and even global economy as global economy integration develops and communication between various countries becomes more frequent. In addition, seasonal influenza, new subtype influenza virus from time to time and avian influenza virus, which occur more than once every year in winter and spring, are a serious threat to human health and the development of animal husbandry.
Disclosure of Invention
The invention aims to provide an application of a ephedra and apricot lung-ventilating traditional Chinese medicine composition as an influenza virus treatment medicine.
The technical scheme for realizing the purpose of the invention is as follows: the application of the ephedra and apricot lung-ventilating traditional Chinese medicine composition as an influenza virus treatment medicine is used for treating influenza virus infection fever and viral respiratory inflammation; the lung-ventilating ephedra-almond traditional Chinese medicine composition is prepared from ephedra, bitter apricot kernel (blanched), liquorice, platycodon grandiflorum, thunberg fritillary bulb, houttuynia cordata, honeysuckle or lonicera confusa and dried orange peel.
The ephedra and apricot lung-ventilating traditional Chinese medicine composition is applied to treating fever caused by influenza virus infection, and is particularly applied to treating fever caused by influenza A H1N1 virus infection.
The ephedra and apricot lung-ventilating traditional Chinese medicine composition is applied to treating viral respiratory tract inflammation, and is particularly applied to treating viral pneumonia. The viral pneumonia is novel coronavirus pneumonia.
The raw material medicaments used in the invention have the following effects:
herba ephedrae: the traditional Chinese medicine has strong efficacies of warming and sweating to relieve exterior syndrome, inducing diuresis and relieving swelling, is mainly used for treating wind-cold exterior syndrome, chest distress, cough and asthma, edema due to wind-cold, rheumatic arthralgia, deep carbuncle in the yin, phlegm nodule, and the honey ephedra has warm and moist properties, has mild pungent and sweating dispelling effects, enhances the efficacy of moistening lung and relieving cough, has the advantages of freeing lung and relieving asthma and relieving cough, and is mainly used for relieving exterior syndrome, asthma and cough.
Bitter almond (blanched): it enters lung and large intestine, has effects of lowering qi, relieving cough and asthma, loosening bowel to relieve constipation, and can be used for treating cough and asthma, fullness in chest, excessive phlegm, blood deficiency, dry body fluid, and constipation due to intestinal dryness.
Licorice root: invigorating spleen and replenishing qi, clearing heat and detoxicating, eliminating phlegm and relieving cough, relieving spasm and pain, and harmonizing the drugs, and can be used for treating weakness of spleen and stomach, listlessness and debilitation, cardiopalmus and short breath, cough with excessive phlegm, abdominal cavity, limb spasm and pain, carbuncle swelling and sore toxin, and relieving drug intensity.
Balloon flower: to disperse lung qi, to help disperse hair, dispel phlegm and discharge pus to stop cough and asthma.
Thunberg fritillary bulb: clearing and resolving heat phlegm and nourishing the lung, and the alkaloid fritillaria cirrhosa essence has a protective effect on acute lung injury.
Houttuynia cordata: the effective component houttuynin can enhance phagocytic ability of leukocyte, and increase serum properdin, which is obviously increased when treating chronic tracheitis.
Honeysuckle or lonicera confusa: dispel wind-heat externally to relieve exterior pathogen and interior remove heat-toxin to relieve heat stagnation. Since ancient times, lonicera confusa is known as a holy drug for clearing heat and removing toxicity, and researches prove that the lonicera confusa or lonicera confusa contains active ingredients such as chlorogenic acid, luteolin glycoside and the like, has stronger inhibitory effect on various pathogenic bacteria such as hemolytic streptococcus, staphylococcus aureus and the like, upper respiratory infection pathogenic viruses and the like, and can also enhance the immunity.
Dried orange peel: pungent and bitter with the actions of dispersing and purging, light ascending and floating, specially coordinating the qi activities of the spleen and lung to help dispersing and descending, regulating qi and relieving chest stuffiness, drying dampness and resolving phlegm.
The ephedra and apricot lung-ventilating traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 100 parts of houttuynia cordata, 30-70 parts of honeysuckle or lonicera confusa, 25-45 parts of semen armeniacae amarae (blanched), 25-45 parts of platycodon grandiflorum, 20-40 parts of thunberg fritillary bulb, 15-35 parts of ephedra, 10-30 parts of dried orange peel and 8-20 parts of liquorice.
Preferably, the preparation method of the ephedra and apricot lung-ventilating traditional Chinese medicine composition comprises the following steps:
firstly, extracting thunberg fritillary bulb in proportion by using ethanol, concentrating and drying an extracting solution to obtain an extract for later use; collecting volatile oil of herba Houttuyniae and pericarpium Citri Tangerinae at a certain proportion, extracting with water, concentrating the extractive solution for use or drying; extracting flos Lonicerae or flos Lonicerae, semen Armeniacae amarum (blanched), radix Platycodi, herba Ephedrae, and Glycyrrhrizae radix with water, and drying the extractive solution or mixing with the concentrated extractive solution of herba Houttuyniae and pericarpium Citri Tangerinae and drying; mixing the volatile oil obtained by the above extraction and the extract obtained by the extraction and drying.
Preferably, the preparation method of the ephedra and apricot lung-ventilating traditional Chinese medicine composition comprises the following steps:
firstly, extracting thunberg fritillary bulb in proportion by using ethanol, concentrating and drying an extracting solution to obtain an extract for later use; collecting volatile oil of herba Houttuyniae, flos Lonicerae or flos Lonicerae and pericarpium Citri Tangerinae at a certain proportion, extracting with water, and concentrating the extractive solution for use or drying; extracting semen Armeniacae amarum (blanched), radix Platycodi, herba Ephedrae, and Glycyrrhrizae radix with water, and drying the extractive solution or mixing with the concentrated extractive solutions of herba Houttuyniae, flos Lonicerae or flos Lonicerae and pericarpium Citri Tangerinae, and drying; mixing the above volatile oil and the extract obtained by extraction and drying.
Preferably, the preparation method of the ephedra and apricot lung-ventilating traditional Chinese medicine composition comprises the following steps:
extracting the components in proportion with ethanol or water, concentrating and drying the extract to obtain the extract.
Preferably, the preparation method of the ephedra and apricot lung-ventilating traditional Chinese medicine composition comprises the following steps:
firstly, grinding thunberg fritillary bulb into fine powder for later use according to a proportion; extracting the other components in proportion with ethanol or water, concentrating and drying the extractive solution to obtain extract, and mixing with the above Bulbus Fritillariae Thunbergii fine powder.
By adopting the technical scheme, the invention has the following beneficial effects: the invention discovers a new medical application of the ephedra and apricot lung-ventilating traditional Chinese medicine composition, so that the ephedra and apricot lung-ventilating traditional Chinese medicine composition is applied to treating fever caused by influenza virus infection and viral respiratory tract inflammation, can effectively relieve symptoms of fever caused by influenza virus infection and viral respiratory tract inflammation and can cure fever caused by influenza virus infection and viral respiratory tract inflammation.
Detailed Description
Example one
The ephedra and apricot lung-ventilating traditional Chinese medicine composition is applied to treating influenza virus infected hair dyeing fever. The lung-ventilating ephedra and apricot kernel Chinese medicinal composition is prepared from ephedra, semen armeniacae amarae (blanched), liquorice, platycodon grandiflorum, thunberg fritillary bulb, houttuynia cordata, honeysuckle or lonicera confusa and dried orange peel.
The ephedra and apricot lung-ventilating traditional Chinese medicine composition is applied to treating fever caused by influenza virus infection, and is particularly applied to treating fever caused by influenza A H1N1 virus infection.
And (3) observation of clinical experiments: the invention carries out clinical observation and treatment on 300 patients, wherein the patients are male and female in all ages, the maximum age is 80 years old, the minimum age is only 16 years old, and the patients are all infected with influenza A H1N1 and have fever. The treatment method comprises the following steps: the ephedra and apricot lung-ventilating traditional Chinese medicine composition is orally taken by water, and is decocted once a day, and 7 days are a course of treatment.
The evaluation standard of curative effect is as follows:
and (3) curing: the clinical symptoms and physical signs disappear, the functional activities return to normal, and the indexes return to normal after being checked.
Improvement: the clinical symptoms are obviously improved or improved, and each index is slightly improved after the examination.
And (4) invalidation: the clinical symptoms and signs are not improved, and the examination indexes are not improved.
The treatment effect is as follows: clinical research results of a plurality of three hospitals, namely a first auxiliary hospital of western medicine university, a Hunan elegant hospital of China-south university, an auxiliary hospital of China medical research institute in Hunan province, a traditional Chinese medicine institute in Hunan province and the like show that: overall efficacy in 300 treatment groups: the significant efficiency is 65.00 percent, the effective rate is 95.00 percent, and the traditional Chinese medicine symptom curative effect is as follows: the significant efficiency is 60.00 percent, and the effective rate is 87.50 percent.
Example two
The ephedra and apricot lung-ventilating traditional Chinese medicine composition is used for treating viral respiratory tract inflammation, and the ephedra and apricot lung-ventilating traditional Chinese medicine composition is used for treating viral respiratory tract inflammation. The lung-ventilating ephedra and apricot kernel Chinese medicinal composition is prepared from ephedra, semen armeniacae amarae (blanched), liquorice, platycodon grandiflorum, thunberg fritillary bulb, houttuynia cordata, honeysuckle or lonicera confusa and dried orange peel.
The ephedra and apricot lung-ventilating traditional Chinese medicine composition is applied to treating viral respiratory tract inflammation, and is particularly applied to treating viral pneumonia. Viral pneumonia is a novel coronavirus pneumonia.
The raw material medicaments used in the invention have the following effects:
herba Ephedrae. The traditional Chinese medicine has strong efficacies of warming and sweating to relieve exterior syndrome, inducing diuresis and relieving swelling, is mainly used for treating wind-cold exterior syndrome, chest distress, cough and asthma, edema due to wind-cold, rheumatic arthralgia, deep carbuncle in the yin, phlegm nodule, and the honey ephedra has warm and moist properties, has mild pungent and sweating dispelling effects, enhances the efficacy of moistening lung and relieving cough, has the advantages of freeing lung and relieving asthma and relieving cough, and is mainly used for relieving exterior syndrome, asthma and cough.
Bitter apricot kernel (blanched). It enters lung and large intestine, has effects of lowering qi, relieving cough and asthma, loosening bowel to relieve constipation, and can be used for treating cough and asthma, fullness in chest, excessive phlegm, blood deficiency, dry body fluid, and constipation due to intestinal dryness.
Licorice root: invigorating spleen and replenishing qi, clearing heat and detoxicating, eliminating phlegm and relieving cough, relieving spasm and pain, and harmonizing the drugs, and can be used for treating weakness of spleen and stomach, listlessness and debilitation, cardiopalmus and short breath, cough with excessive phlegm, abdominal cavity, limb spasm and pain, carbuncle swelling and sore toxin, and relieving drug intensity.
Balloon flower: to disperse lung qi, to help disperse hair, dispel phlegm and discharge pus to stop cough and asthma.
Thunberg fritillary bulb: clearing and resolving heat phlegm and nourishing the lung, and the alkaloid fritillaria cirrhosa essence has a protective effect on acute lung injury.
Houttuynia cordata: the effective component houttuynin can enhance phagocytic ability of leukocyte, and increase serum properdin, which is obviously increased when treating chronic tracheitis.
Honeysuckle or lonicera confusa: dispel wind-heat externally to relieve exterior pathogen and interior remove heat-toxin to relieve heat stagnation. Since ancient times, lonicera confusa is known as a holy drug for clearing heat and removing toxicity, and researches prove that the lonicera confusa contains active ingredients such as chlorogenic acid, luteolin glycoside and the like, has stronger inhibition on various pathogenic bacteria such as hemolytic streptococcus, staphylococcus aureus and the like, upper respiratory infection pathogenic viruses and the like, and can also enhance the immunity.
Dried orange peel: pungent and bitter with the actions of dispersing and purging, light ascending and floating, specially coordinating the qi activities of the spleen and lung to help dispersing and descending, regulating qi and relieving chest stuffiness, drying dampness and resolving phlegm.
The application of the ephedra and apricot lung-ventilating traditional Chinese medicine composition in the treatment of the novel coronavirus pneumonia is studied by taking the ephedra and apricot lung-ventilating traditional Chinese medicine composition as an example.
1. Experimental materials and methods of administration: 10 Kunming mice of 18-22g which were positive in nucleic acid detection were prepared. The ephedra and apricot lung-ventilating traditional Chinese medicine composition is prepared into a concentrated medicament, and each white mouse is irrigated with 4g per time every day.
2. And (3) experimental observation: the observation period is 15 days, wherein CT lung imaging shooting is carried out on the mice every three days, and lung disease grouping is observed according to the CT imaging shooting, the mice with white spots on the lungs are grouped into an uncured group, the mice with no white spots on the lungs are grouped into a cured group, the administration of the drug in the cured group is stopped, the nucleic acid detection is carried out again, and the drug administration of the uncured group is continued and the observation is continued.
3. The experimental results are as follows: the experiment was carried out for 16 days, and 9 surviving mice were treated in the cured group, and 1 dead mouse was treated in the non-cured group.
EXAMPLE III
The ephedra and apricot lung-ventilating traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 100 parts of houttuynia cordata, 30-70 parts of honeysuckle or lonicera confusa, 25-45 parts of semen armeniacae amarae (blanched), 25-45 parts of platycodon grandiflorum, 20-40 parts of thunberg fritillary bulb, 15-35 parts of ephedra, 10-30 parts of dried orange peel and 8-20 parts of liquorice.
Preferably, the preparation method of the ephedra and apricot lung-ventilating traditional Chinese medicine composition comprises the following steps:
firstly, extracting thunberg fritillary bulb in proportion by using ethanol, concentrating and drying an extracting solution to obtain an extract for later use. Collecting volatile oil of herba Houttuyniae and pericarpium Citri Tangerinae at a certain proportion, extracting with water, and concentrating the extractive solution for use or drying. Extracting flos Lonicerae or flos Lonicerae, semen Armeniacae amarum (blanched), radix Platycodi, herba Ephedrae, and Glycyrrhrizae radix with water, and drying the extractive solution or mixing with the concentrated extractive solution of herba Houttuyniae and pericarpium Citri Tangerinae and drying. Mixing the volatile oil obtained by the above extraction and the extract obtained by the extraction and drying.
Or, firstly, extracting the thunberg fritillary bulb with ethanol according to a certain proportion, and concentrating and drying the extracting solution to obtain an extract for later use. Collecting volatile oil of herba Houttuyniae, flos Lonicerae or flos Lonicerae and pericarpium Citri Tangerinae, extracting with water, and concentrating the extractive solution or drying. Extracting semen Armeniacae amarum (blanched), radix Platycodi, herba Ephedrae, and Glycyrrhrizae radix with water, and drying the extractive solution or mixing with the concentrated extractive solution of herba Houttuyniae, flos Lonicerae or flos Lonicerae and pericarpium Citri Tangerinae and drying. Mixing the above volatile oil and the extract obtained by extraction and drying.
Or extracting the components in proportion with ethanol or water, concentrating and drying the extract to obtain the extract.
Or, pulverizing Bulbus Fritillariae Thunbergii into fine powder at a certain proportion. Extracting the other components with ethanol or water, concentrating the extractive solution, drying to obtain extract, and mixing with the above Bulbus Fritillariae Thunbergii fine powder.
The above-mentioned embodiments are intended to illustrate the objects, technical solutions and advantages of the present invention in further detail, and it should be understood that the above-mentioned embodiments are only exemplary embodiments of the present invention and are not intended to limit the present invention, and any modifications, equivalents, improvements and the like made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (9)
1. The application of the ephedra and apricot lung-ventilating traditional Chinese medicine composition as a medicine for treating influenza virus is characterized in that: the ephedra and apricot lung-ventilating traditional Chinese medicine composition is applied to treating influenza virus infection fever and viral respiratory inflammation; the lung-ventilating ephedra and apricot kernel Chinese medicinal composition is prepared from ephedra, semen armeniacae amarae (blanched), liquorice, platycodon grandiflorum, thunberg fritillary bulb, houttuynia cordata, honeysuckle or lonicera confusa and dried orange peel.
2. The application of the ephedra and apricot lung-ventilating traditional Chinese medicine composition as an influenza virus treatment medicine according to claim 1 is characterized in that: the ephedra and apricot lung-ventilating traditional Chinese medicine composition is applied to treating fever caused by influenza virus infection, and is particularly applied to treating fever caused by influenza A H1N1 virus infection.
3. The application of the ephedra and apricot lung-ventilating traditional Chinese medicine composition as an influenza virus treatment medicine according to claim 1 is characterized in that: the ephedra and apricot lung-ventilating traditional Chinese medicine composition is applied to viral respiratory inflammation, and is particularly applied to treating viral pneumonia.
4. The application of the ephedra and apricot lung-ventilating traditional Chinese medicine composition as an influenza virus treatment medicine according to claim 3 is characterized in that: the viral pneumonia is novel coronavirus pneumonia.
5. The application of the ephedra and apricot lung-ventilating traditional Chinese medicine composition as an influenza virus treatment medicine according to claim 1 is characterized in that: the ephedra and apricot lung-ventilating traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 100 parts of houttuynia cordata, 30-70 parts of honeysuckle or lonicera confusa, 25-45 parts of semen armeniacae amarae (blanched), 25-45 parts of platycodon grandiflorum, 20-40 parts of thunberg fritillary bulb, 15-35 parts of ephedra, 10-30 parts of dried orange peel and 8-20 parts of liquorice.
6. The application of the ephedra and apricot lung-ventilating traditional Chinese medicine composition as an influenza virus treatment medicine according to claim 5 is characterized in that: the preparation method of the ephedra and apricot lung-ventilating traditional Chinese medicine composition comprises the following steps:
firstly, extracting thunberg fritillary bulb in proportion by using ethanol, concentrating and drying an extracting solution to obtain an extract for later use; collecting volatile oil of herba Houttuyniae and pericarpium Citri Tangerinae at a certain proportion, extracting with water, and concentrating the extractive solution for use or drying; extracting flos Lonicerae or flos Lonicerae, semen Armeniacae amarum (blanched), radix Platycodi, herba Ephedrae, and Glycyrrhrizae radix with water, and drying the extractive solution or mixing with the concentrated extractive solution of herba Houttuyniae and pericarpium Citri Tangerinae and drying; mixing the above volatile oil and the extract obtained by extraction and drying.
7. The application of the ephedra and apricot lung-ventilating traditional Chinese medicine composition as an influenza virus treatment medicine according to claim 5 is characterized in that: the preparation method of the ephedra and apricot lung-ventilating traditional Chinese medicine composition comprises the following steps:
firstly, extracting thunberg fritillary bulb in proportion by using ethanol, concentrating and drying an extracting solution to obtain an extract for later use; collecting volatile oil of herba Houttuyniae, flos Lonicerae or flos Lonicerae and pericarpium Citri Tangerinae, extracting with water, and concentrating the extractive solution or drying; extracting semen Armeniacae amarum (blanched), radix Platycodi, herba Ephedrae, and Glycyrrhrizae radix with water, drying the extractive solution or mixing with the concentrated extractive solution of herba Houttuyniae, flos Lonicerae or flos Lonicerae and pericarpium Citri Tangerinae, and drying; mixing the above volatile oil and the extract obtained by extraction and drying.
8. The application of the ephedra and apricot lung-ventilating traditional Chinese medicine composition as an influenza virus treatment medicine according to claim 5 is characterized in that: the preparation method of the ephedra and apricot lung-ventilating traditional Chinese medicine composition comprises the following steps:
extracting the components in proportion with ethanol or water, concentrating the extractive solution, and drying to obtain extract.
9. The application of the ephedra and apricot lung-ventilating traditional Chinese medicine composition as an influenza virus treatment medicine according to claim 5 is characterized in that: the preparation method of the ephedra and apricot lung-ventilating traditional Chinese medicine composition comprises the following steps:
firstly, grinding thunberg fritillary bulb into fine powder for later use according to a proportion; extracting the other components with ethanol or water, concentrating the extractive solution, drying to obtain extract, and mixing with the above Bulbus Fritillariae Thunbergii fine powder.
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