CN107412585B - Green environment-friendly hand-washing-free disinfection gel and preparation method thereof - Google Patents

Abstract

The invention provides a green environment-friendly hand-washing-free disinfection gel and a preparation method thereof, which relate to the field of sanitary products and are prepared from the following components in percentage by weight: 2-4% of polymer gel matrix, 50-80% of lower alcohol, 0.1-0.8% of isatis root extract, 0.1-0.8% of sweet wormwood herb extract, 0.1-0.8% of licorice extract, 0.5-1% of folium artemisiae argyi extract, 0.5-1% of clove oil, 0.1-0.8% of porphyra yezoensis crude polysaccharide extract, 0.1-1% of aloe extract, 0.1-0.5% of honeysuckle extract, 0.1-0.5% of common andrographis herb extract, 0.2-0.8% of seaweed active element, 0.05-0.1% of lecithin, 1-5% of wheat germ oil, 0.78-1% of tween 800.5, 0.01-0.15% of pH regulator and the balance of water, the invention uses lower alcohol and plant extract as synergistic sterilization and anti-inflammation components and adds skin care components to prepare the hand-washing-free disinfection gel which has stable performance, is green and environment-friendly and, the hand cream has the effect of caring the skin of both hands, has fresh hand feeling after use, is quick-drying, and can effectively prevent the skin of the hands from being dry and chapped.

Description

Green environment-friendly hand-washing-free disinfection gel and preparation method thereof

Technical Field

The invention relates to the field of sanitary articles, in particular to a green environment-friendly hand-washing-free disinfection gel and a preparation method thereof.

Background

Infectious microorganisms can enter hospitals through a variety of different routes, and hospital infection is very likely to be caused due to the complexity of hospital personnel. Hands are warm and moist, and the proper conditions are provided for the growth and the propagation of bacteria. Researches show that hands of medical staff are used as transmission media of various germs and are important factors causing bacterial cross infection. The hospital infection incidence rate can be reduced to a certain extent by increasing the hand washing frequency of patients and medical care personnel, but pathogenic microorganisms cannot be completely removed by only washing hands. And various pathogenic microorganisms on the hand skin can be quickly and effectively killed by using the proper hand disinfectant. Hand disinfection is the simplest and most effective measure for controlling nosocomial infections.

The water-type hand disinfectant liquid drops are easy to splash and drip, and the gel type hand disinfectant liquid drops can effectively prevent the disinfectant from splashing and dripping. The disinfectant is prepared into a gel form, and the medical care personnel can adopt a kneading surgical washing method, so that the operation is convenient and safe. The traditional disinfectant brushing method reduces the comfortable feeling of the skin of medical workers, has great damage to the feeling, appearance and integrity of the skin of hands, easily causes the accumulation and release of the colonizing bacteria in the deep parts of the hands, and increases the probability of surgical infection. The hand washing method by rubbing the disinfection gel avoids the process that the operating personnel washes and soaks hands by using the disinfection solution, thereby not only saving the hand washing time of preoperative surgery, but also not influencing the hand disinfection effect, having smaller damage to hands and increasing the hand washing compliance of the operating personnel.

Chinese patent with application publication number CN102614113A discloses a composite no-clean disinfection gel, which is mainly characterized in that the weight percentage of the raw materials is as follows: 0.05 to 0.5 percent of quaternary ammonium salt disinfectant, 50 to 90 percent of ethanol, 1 to 5 percent of humectant, 0.1 to 0.6 percent of thickening agent and 3.9 to 48.85 percent of deionized water are mixed and stirred to obtain the disinfectant. Although the invention has the advantages of convenient use and easy application, the quaternary ammonium salt disinfectant has no added skin-care components and has large irritation to skin, side reactions such as skin allergy and the like can be caused, and the problems of rough skin, chapping skin and even peeling skin and the like can be easily caused after long-term use.

Disclosure of Invention

Technical problem to be solved

Aiming at the defects of the prior art, the invention provides the green environment-friendly hand-washing-free disinfection gel and the preparation method thereof, the gel has the characteristics of environmental protection, no toxicity, good tissue compatibility and good film forming property, can effectively resist wrinkles, prevent wrinkles and protect skin and moisture, and has simple preparation process and good inhibition effect on common bacteria.

(II) technical scheme

In order to achieve the purpose, the invention is realized by the following technical scheme:

the green environment-friendly hand-washing-free disinfection gel is prepared from the following components in percentage by weight: 2-4% of polymer gel matrix, 50-80% of lower alcohol, 0.1-0.8% of isatis root extract, 0.1-0.8% of sweet wormwood herb extract, 0.1-0.8% of licorice extract, 0.5-1% of folium artemisiae argyi extract, 0.5-1% of clove oil, 0.1-0.8% of porphyra yezoensis crude polysaccharide extract, 0.1-1% of aloe extract, 0.1-0.5% of honeysuckle extract, 0.1-0.5% of common andrographis herb extract, 0.2-0.8% of seaweed active element, 0.05-0.1% of lecithin, 1-5% of wheat germ oil, 0.01-0.15% of Tween 800.5, 0.01-0.15% of pH regulator and the balance of water.

Preferably, the polymer gel matrix is one or more of hydroxypropyl methyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, methyl cellulose, sodium alginate, chitin derivatives and polyacrylamide.

Preferably, the lower alcohol is a mixture of ethanol and isopropanol.

Preferably, the pH regulator is one or more of lactic acid, citric acid or malic acid.

The preparation method of the disinfection gel comprises the following steps:

(1) weighing the raw materials in proportion;

(2) adding the polymer gel matrix into cold water, controlling the stirring speed at 70-100r/min and the heating speed at 1 ℃/min, and heating until the polymer gel matrix is completely dissolved;

(3) after the macromolecule gel matrix is completely dissolved, adding lower alcohol, isatis root extract, sweet wormwood herb extract, liquorice extract, folium artemisiae argyi extract, clove oil, crude porphyra yezoensis polysaccharide extract, aloe extract, honeysuckle extract, andrographis paniculata extract, kaempferol, lecithin, wheat germ oil and tween 80 in batches, stirring until a system becomes a uniform solution, adding a pH regulator, regulating the pH value of the system to 6-7, stirring for 5-10h, cooling and standing for 24h to obtain clear and transparent gel.

(4) And sterilizing the obtained clear and transparent gel, filling and sealing to obtain the green environment-friendly hand-washing-free sterilization gel.

Preferably, the sterilization mode in the step (4) is ultraviolet sterilization.

The low-grade alcohol has excellent sterilization capability, has low boiling point, can be quickly volatilized when being applied to the skin, can play a role in quick drying, does not have residues after being volatilized, has low price, and can reduce the cost of the no-clean disinfection gel.

The isatis root extract has an inhibiting effect on various bacteria and viruses, and particularly has an obvious effect on staphylococcus aureus, escherichia coli, typhoid bacillus, paratyphoid bacillus and dysentery bacillus.

The sweet wormwood herb extract has strong bacteriostatic action on staphylococcus epidermidis, catacoccus, bacillus anthracis and diphtheria bacillus, and also has certain inhibitory action on staphylococcus aureus, pseudomonas aeruginosa, shigella dysenteriae, tubercle bacillus and the like.

Licorice flavone in licorice root has anti-inflammatory activity, and preclinical test results show that the flavone can kill most of helicobacter pylori causing gastric ulcer and enteritis.

The folium Artemisiae Argyi extract has inhibitory effect on Bacillus anthracis, alpha hemolytic streptococcus, beta hemolytic streptococcus, diphtheria bacillus, Diplococcus pneumoniae, Staphylococcus aureus, Bacillus subtilis, etc., and also has inhibitory effect on common pathogenic dermatophytes.

Clinical researches in hospitals find that clove oil has a strong bactericidal effect, can kill helicobacter pylori, and has an inhibiting effect on staphylococcus, streptococcus, escherichia coli, typhoid bacillus, pseudomonas aeruginosa and the like.

The porphyra yezoensis crude polysaccharide extract and the aloe extract not only have the effects of sterilization and anti-inflammation, but also can improve skin quality, moisturize and lock water, and the marine algae active element is an active ingredient which is extracted from various marine algae and has the antibacterial effect, has the characteristics of no toxicity, no stimulation and high antibacterial efficiency, can effectively inhibit the propagation of escherichia coli, staphylococcus aureus and candida albicans, reduces the harm of bacteria to human bodies, has strong adhesion, can be remained on the surface of skin for a long time, and plays a long-term antibacterial effect.

The wheat germ oil is a cereal germ oil prepared from wheat malt, can promote skin metabolism, and has effects of resisting wrinkle, preventing skin aging, eliminating scar, promoting skin moisture, and moistening skin.

The honeysuckle extract and the andrographis paniculata extract have obvious bacteriostatic activity, are natural Chinese herbal medicine extracts, are mild in property and free of irritation to human bodies, and have high bacterial killing rate under the synergistic action of the honeysuckle extract and the andrographis paniculata extract.

(III) advantageous effects

The invention provides a green environment-friendly hand-free disinfection gel, which is prepared by taking lower alcohol and plant extract as synergistic sterilization and inflammation diminishing components and adding skin-care and moisture-retention components, has stable performance, has the effects of quickly sterilizing, being green, environment-friendly and non-irritant, and caring the skin of hands, and has fresh and cool hand feeling after being used, quick drying and effective prevention of hand skin from being dry and chapped.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Example 1:

the green environment-friendly hand-washing-free disinfection gel is prepared from the following components in percentage by weight: 3% of hydroxypropyl methyl cellulose, 70% of lower alcohol, 0.5% of isatis root extract, 0.5% of sweet wormwood herb extract, 0.5% of liquorice extract, 0.5% of folium artemisiae argyi extract, 1% of clove oil, 0.5% of porphyra yezoensis crude polysaccharide extract, 0.5% of aloe extract, 0.2% of honeysuckle extract, 0.3% of andrographis paniculata extract, 0.6% of seaweed active element, 0.07% of lecithin, 4% of wheat germ oil, 4% of tween 800.7, 0.1% of pH regulator and the balance of water.

Wherein, the lower alcohol is formed by mixing ethanol and isopropanol according to the weight ratio of 1: 1.

Wherein the pH regulator is formed by mixing lactic acid and citric acid according to the weight ratio of 1: 2.

The preparation method of the disinfection gel comprises the following steps:

(1) weighing the raw materials in proportion;

(2) adding hydroxypropyl methyl cellulose into cold water, controlling the stirring speed at 80r/min and the heating speed at 1 ℃/min, and heating until the macromolecular gel matrix is completely dissolved;

(3) after the hydroxypropyl methyl cellulose is completely dissolved, adding lower alcohol, an isatis root extract, a sweet wormwood herb extract, a liquorice extract, a folium artemisiae argyi extract, clove oil, a porphyra yezoensis crude polysaccharide extract, an aloe extract, a honeysuckle extract, an andrographis paniculata extract, a seaweed active substance, lecithin, wheat germ oil and tween 80 in batches, stirring until a system becomes a uniform solution, adding a pH regulator, regulating the pH value of the system to 6-7, stirring for 5 hours, cooling and standing for 24 hours to obtain clear and transparent gel.

(4) And sterilizing the obtained clear and transparent gel by ultraviolet rays, filling and sealing to obtain the green environment-friendly hand-washing-free sterilization gel.

Example 2:

the green environment-friendly hand-washing-free disinfection gel is prepared from the following components in percentage by weight: 4% of polymer gel matrix, 80% of lower alcohol, 0.1% of isatis root extract, 0.4% of sweet wormwood herb extract, 0.8% of licorice extract, 1% of folium artemisiae argyi extract, 0.5% of clove oil, 0.2% of crude porphyra yezoensis polysaccharide extract, 1% of aloe extract, 0.4% of honeysuckle extract, 0.5% of andrographis paniculata extract, 0.2% of seaweed active element, 0.05% of lecithin, 1% of wheat germ oil, tween 800.9, 0.07% of pH regulator and the balance of water.

Wherein the polymer gel matrix is prepared by mixing hydroxyethyl cellulose, hydroxypropyl cellulose and methyl cellulose according to the weight ratio of 1:2: 1.

Wherein, the lower alcohol is formed by mixing ethanol and isopropanol according to the weight ratio of 2: 1.

The preparation method of the disinfection gel comprises the following steps:

(1) weighing the raw materials in proportion;

(2) adding the polymer gel matrix into cold water, controlling the stirring speed at 70r/min and the heating speed at 1 ℃/min, and heating until the polymer gel matrix is completely dissolved;

(3) after the macromolecule gel matrix is completely dissolved, adding lower alcohol, isatis root extract, sweet wormwood herb extract, liquorice extract, folium artemisiae argyi extract, clove oil, crude porphyra yezoensis polysaccharide extract, aloe extract, honeysuckle extract, andrographis paniculata extract, kaempferol, lecithin, wheat germ oil and tween 80 in batches, stirring until the system becomes a uniform solution, adding lactic acid, adjusting the pH value of the system to 6-7, stirring for 10h, cooling and standing for 24h to obtain clear and transparent gel.

(4) And sterilizing the obtained clear and transparent gel by ultraviolet rays, filling and sealing to obtain the green environment-friendly hand-washing-free sterilization gel.

Example 3:

the green environment-friendly hand-washing-free disinfection gel is prepared from the following components in percentage by weight: 2% of polymer gel matrix, 60% of lower alcohol, 0.8% of isatis root extract, 0.1% of sweet wormwood herb extract, 0.1% of licorice extract, 0.8% of folium artemisiae argyi extract, 0.8% of clove oil, 0.8% of porphyra yezoensis crude polysaccharide extract, 0.8% of aloe extract, 0.5% of honeysuckle extract, 0.1% of andrographis paniculata extract, 0.5% of seaweed active element, 0.08% of lecithin, 5% of wheat germ oil, tween 801, 0.15% of pH regulator and the balance of water.

Wherein the macromolecular gel matrix is formed by mixing hydroxyethyl cellulose, sodium alginate and polyacrylamide according to the weight ratio of 1:1: 1.

Wherein, the lower alcohol is formed by mixing ethanol and isopropanol according to the weight ratio of 3: 1.

The preparation method of the disinfection gel comprises the following steps:

(1) weighing the raw materials in proportion;

(2) adding the polymer gel matrix into cold water, controlling the stirring speed at 100r/min and the heating speed at 1 ℃/min, and heating until the polymer gel matrix is completely dissolved;

(3) after the macromolecule gel matrix is completely dissolved, adding lower alcohol, isatis root extract, sweet wormwood herb extract, liquorice extract, folium artemisiae argyi extract, clove oil, crude porphyra yezoensis polysaccharide extract, aloe extract, honeysuckle extract, andrographis paniculata extract, kaempferide, lecithin, wheat germ oil and tween 80 in batches, stirring until a system becomes a uniform solution, adding malic acid, adjusting the pH value of the system to 6-7, stirring for 8 hours, cooling and standing for 24 hours to obtain clear and transparent gel.

(4) And sterilizing the obtained clear and transparent gel by ultraviolet rays, filling and sealing to obtain the green environment-friendly hand-washing-free sterilization gel.

Example 4:

the green environment-friendly hand-washing-free disinfection gel is prepared from the following components in percentage by weight: 3% of polymer gel matrix, 50% of lower alcohol, 0.2% of isatis root extract, 0.4% of sweet wormwood herb extract, 0.3% of licorice extract, 1% of folium artemisiae argyi extract, 0.5% of clove oil, 0.1% of crude porphyra yezoensis polysaccharide extract, 0.1% of aloe extract, 0.1% of honeysuckle extract, 0.5% of andrographis paniculata extract, 0.6% of seaweed active element, 0.1% of lecithin, 1% of wheat germ oil, 1% of tween 800.5, 0.01% of pH regulator and the balance of water.

The preparation method of the disinfection gel is basically the same as that of the disinfection gel in the embodiment 1, and is different in that the macromolecule gel matrix is chitin derivative, the lower alcohol is ethanol and isopropanol which are mixed according to the weight ratio of 4:1, the pH regulator is citric acid, the stirring speed in the step (2) is 70r/min, and the stirring time after the pH value is regulated in the step (3) is 6 hours.

Example 5:

the green environment-friendly hand-washing-free disinfection gel is prepared from the following components in percentage by weight: 4% of polymer gel matrix, 80% of lower alcohol, 0.1% of isatis root extract, 0.7% of sweet wormwood herb extract, 0.5% of liquorice extract, 0.5% of folium artemisiae argyi extract, 0.6% of clove oil, 0.5% of porphyra yezoensis crude polysaccharide extract, 0.6% of aloe extract, 0.2% of honeysuckle extract, 0.5% of andrographis paniculata extract, 0.8% of seaweed active element, 0.06% of lecithin, 4% of wheat germ oil, 800.6% of tween, 0.12% of pH regulator and the balance of water.

The preparation method of the disinfection gel is basically the same as that of the disinfection gel in example 1, and the difference is that the macromolecule gel matrix is hydroxyethyl cellulose and methyl cellulose according to the weight ratio of 1:2, the lower alcohol is ethanol and isopropanol which are mixed according to the weight ratio of 5:1, the pH regulator is lactic acid, citric acid and malic acid which are mixed according to the weight ratio of 1:1:1, the stirring speed in the step (2) is 90r/min, and the stirring time after the pH value is adjusted in the step (3) is 9 hours.

The invention relates to a hand-washing-free disinfection gel bacterium quantitative killing experimental result:

the results of quantitative sterilization experiments of the hand-free gel bacteria prepared in examples 1 to 5 are shown in table 1, wherein the sterilization effect is the sterilization rate after 25 seconds of sterilization:

table 1: results of the experiment

In conclusion, the embodiment of the invention has the beneficial effects of good sterilization effect, multiple types of sterilization bacteria and short sterilization time.

It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising an … …" does not exclude the presence of other identical elements in a process, method, article, or apparatus that comprises the element.

The above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.

Claims (5)

1. The green environment-friendly hand-washing-free disinfection gel is characterized by being prepared from the following components in percentage by weight: 2-4% of polymer gel matrix, 50-80% of lower alcohol, 0.1-0.8% of isatis root extract, 0.1-0.8% of sweet wormwood herb extract, 0.1-0.8% of licorice extract, 0.5-1% of folium artemisiae argyi extract, 0.5-1% of clove oil, 0.1-0.8% of porphyra yezoensis crude polysaccharide extract, 0.1-1% of aloe extract, 0.1-0.5% of honeysuckle extract, 0.1-0.5% of common andrographis herb extract, 0.2-0.8% of seaweed active element, 0.05-0.1% of lecithin, 1-5% of wheat germ oil, 0.01-0.15% of Tween 800.5, 0.01-0.15% of pH regulator and the balance of water, wherein the lower alcohol is formed by mixing ethanol and isopropanol.

2. The environment-friendly hand-free disinfection gel as claimed in claim 1, wherein the polymer gel matrix is one or more of hydroxypropyl methylcellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, methylcellulose, sodium alginate, chitin derivatives and polyacrylamide.

3. The environment-friendly hand-free disinfection gel as claimed in claim 1, wherein the pH regulator is one or more of lactic acid, citric acid or malic acid.

4. The method for preparing green environment-friendly no-wash hand disinfection gel as claimed in claim 1, characterized by comprising the following steps:

(1) weighing the raw materials in proportion;

(2) adding the polymer gel matrix into cold water, controlling the stirring speed at 70-100r/min and the heating speed at 1 ℃/min, and heating until the polymer gel matrix is completely dissolved;

(3) after the macromolecule gel matrix is completely dissolved, adding lower alcohol, isatis root extract, sweet wormwood herb extract, liquorice extract, folium artemisiae argyi extract, clove oil, crude porphyra yezoensis polysaccharide extract, aloe extract, honeysuckle extract, andrographis paniculata extract, kaempferol, lecithin, wheat germ oil and tween 80 in batches, stirring until a system becomes a uniform solution, adding a pH regulator, regulating the pH value of the system to 6-7, stirring for 5-10h, cooling and standing for 24h to obtain clear and transparent gel;

(4) and sterilizing the obtained clear and transparent gel, filling and sealing to obtain the green environment-friendly hand-washing-free sterilization gel.

5. The method for preparing environment-friendly no-wash hand disinfection gel as claimed in claim 4, wherein the disinfection manner in step (4) is ultraviolet disinfection.