CN110996850B - 可调节光学度数的眼内透镜 - Google Patents
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Abstract
本技术涉及一种可调节度数的眼内透镜,其包括容器,容器中的光学流体,和在光学流体溶液中的运送物。该容器具有光学组件和围绕至少一部分所述光学组件延伸的***组件。所述光学组件具有前光学元件,后光学元件,和在前光学元件和后光学元件之间具有腔室容积的流体腔。运送物被配置成穿过容器。可调节度数的眼内透镜还包括容器中的容积控制元件。容积控制元件被配置成由无创能量激活,并且在激活时将运送物释放到光学流体中以减小腔室容积和/或从光学流体中吸收运送物以增加腔室容积。
Description
背景技术
眼内透镜(人工晶状体,IOL)是用于治疗白内障或近视的可植入光学装置。IOL通常会替换因白内障而浑浊或变色的天然晶状体。通过移除天然晶状体然后将IOL***天然晶状体囊膜而手术地植入IOL。世界卫生组织估计,2010年全世界将植入2000万个IOL,并预测到2020年每年将植入3000万个IOL。
许多现有的IOL都有由制造商设置的一个单一的光学度数。因此,常规的单一度数IOL具有固定的光学度数。这就要求执业医生在植入前要确定单一度数IOL的光学度数。然而,IOL的光学度数在植入后可能是不正确的,因为该IOL可能在天然晶状体囊膜内并不那么适合或者眼睛可能会随着时间而改变。如果已植入的单一度数IOL的光学度数不正确,则该IOL需要通过另一个手术过程被替换为另一个具有合适的光学度数的IOL。这不仅增加医疗费用,还给患者带来不便,并且容易出现光学手术过程的常见并发症。
附图说明
参考以下附图可以更好地理解本技术的多个方面。附图中的组件不一定按比例绘制。而是将重点放在清楚地说明本技术的原理上。此外,组件可以在某些视图中显示为透明的,这只是为了清楚地说明,而不是表示该组件必须是透明的。组件也可以示意性地被显示。
图1是根据本技术的可调节度数的眼内透镜的剖视图。
图2和图3分别是根据本技术的在可调节度数的眼内透镜中使用的第一和第二容积控制元件的操作的剖视图。
图4是根据本技术的可调节度数的眼内透镜的剖视图。
图5是根据本技术的可调节度数的眼内透镜的剖视图。
图6是根据本技术的可调节度数的眼内透镜的剖视图。
图7是根据本技术的可调节度数的眼内透镜的平面图。
图8A是根据本技术的可调节度数的眼内透镜的等距视图,图8B是沿图8A的截面A-A得到的剖视图。
图9A是示出了根据本技术的模块化的APIOL的等距视图,图9B是其底部平面图,以及图9C是沿着图9B的截面A-A得到的剖视图。
图10A是固定的透镜的底部等距视图,以及图10B是沿着图10A的截面B-B得到的剖视图。
概述
下面参考图1-8描述根据本技术的可调节度数的眼内透镜(APIOL)的多个实施例。下面描述的APIOL能够使用无创激活来就地改变光学度数。尽管针对单一度数装置公开了多种APIOL的示例,但该构思可应用于如下所述的调适性眼内透镜。
本公开的APIOL提供了可选择地就地改变光学度数以使该APIOL在植入后适应到患者所需的特定度数而不需要移除和/或替换该APIOL的能力。例如,根据本技术的APIOL的多个实施例包括释放或排出运送物的第一容积控制元件和/或吸收或吸引和保留运送物的第二容积控制元件。第一容积控制元件可以是收缩元件或释放元件,其被配置成在无创激活(例如可选择地与第一容积控制元件反应的能量形式)时释放运送物。相反地,第二容积控制元件可以是膨胀元件,其被配置成在无创激活时吸收或吸引和保留运送物。在操作中,可以激活收缩元件来从APIOL释放运送物以降低光学度数,或者相反地,可以激活膨胀元件来吸收运送物以增加光学度数。
根据本技术的APIOL可以包括容器,在该容器中的光学流体,和在该容器中的容积控制元件。容器可以包括***组件和光学组件。例如,光学组件可以包括前光学元件和后光学元件。光学元件可以是亲水的或疏水的。容器可包括透水材料。用于容器的适合的透水材料包括:
a-亲水性丙烯酸共聚物(hydrophilic acrylic copolymer);
b-由佛罗里达州萨拉索塔的奔驰研发公司制造的奔驰25UVXTM材料;以及
c-英国康塔马克公司生产的Cl18,Cl21,或Cl26适合的亲水性丙烯酸(hydrophilic acrylics)包括但不限于甲基丙烯酸2-羟乙酯(2-Hydroxyethylmethacrvlate(HEMA))。适合的疏水性丙烯酸(hydrophobic acrylics)包括但不限于甲基丙烯酸2-乙氧基乙酯(2-Ethoxyethyl methacrvlate(EOEMA)),聚甲基丙烯酸甲酯(polymethyl methacrylate(PMMA)),丙烯酸丁酯(Butyl acrylate),丙烯酸己酯(Hexylacrvlate),和丙烯酸六氟异丙酯(Hexafluoroisopropyl acrylate)。例如,丙烯酸可以包括交联剂。在一些实施例中,丙烯酸包括交联丙烯酸聚合物(cross-linked acrylicpolymer)。亲水性或疏水性聚合物可以是上述聚合物的共聚物。
填充容器的内部光学流体可以包括油。例如,该油的折射率可以大于眼房水的折射率。该油能够在人眼睛的体温下保持溶液中的水的饱和量。运送物可以是水。
容积控制元件可以包括第一容积控制元件,其被配置成将运送物释放到容器中的光学流体中,和/或第二容积控制元件,其被配置成从光学流体中吸收运送物。第一容积控制元件可以是收缩元件,当被激活时,其将运送物释放到光学流体中,从而增加流体腔中该运送物的容积。这会导致容器中的运送物浓度超过饱和点,从而通过扩散将运送物从容器中运送到眼房水。运送物的减少减少了容器中物质的容积,进而降低了光学组件的光学度数。第二容积控制元件可以是膨胀元件,其在激活时从光学流体吸收运送物。这也会导致容器内运送物的不平衡,使得额外的运送物通过扩散从眼房水中运送到容器中。运送物的增加增加了容器中物质的容积,从而增加了光学元件的光学度数。
第一容积控制元件或收缩元件可以包括包含一定容积的运送物的第一疏水性壳。例如,运送物可以是水,并且第一疏水性壳可以是蜡或脂质体(例如单层脂质体)。在一个示例中,第一容积控制元件可以是含水的蜡质闭孔海绵状体。
第二容积控制元件或膨胀元件可包括被第二疏水性壳包围的一个或多个亲水元件。亲水元件可包括水凝胶,例如丙烯酸聚合物。第二疏水性壳可包括聚对二甲苯(parylene)和/或疏水性丙烯酸(hydrophobic acrylic)。
第一和/或第二容积控制元件可以被固定到容器。在其他实施例中,第一和/或第二容积控制元件可以悬浮在光学流体中。
根据本技术的APIOL的光学组件可以是流体透镜,其包括由前光学元件和后光学元件界定的光学流体(例如,油)。***组件可以围绕光学组件,使得光学组件是容器的中间部分。在一些实施例中,前光学元件和后光学元件其中之一或两者可以具有光学度数(即,在松弛的无偏状态下的限定的曲度),使得光学组件在松弛的状态下具有光学度数。在其他实施例中,前光学元件和/或后光学元件可以是平坦膜,其在松弛的无偏状态下不具有光学度数,使得光学组件在松弛的状态下不具有度数。容器内的光学流体,运送物以及第一和/或第二容积控制元件的总容积可以改变光学组件的曲度,从而改变光学组件的光学度数。更具体地,当容器内的物质的容积增加时,光学度数增大,或者相反地,当容器内的物质的容积减小时,光学度数减小。
通过可选择地激活第一容积控制元件或第二容积控制元件来控制容器内的物质的容积。第一或第二容积控制元件可以通过破坏该容积控制元件的全部或一部分疏水性壳而被激活。例如,在一些实施例中,通过将容积控制元件暴露于无创激活能量来激活容积控制元件,该无创激活能量可选择地破坏第一容积控制元件的第一疏水性壳或第二容积控制元件的第二疏水性壳。无创激活能量可以包括激光能量(例如光),超声,电能(例如射频),和/或红外。
具体实施例
图1是示意性地示出具有***组件110和光学组件120的APIOL 100的剖视图。***组件110和光学组件120可以一起限定容器,或者可以仅以***组件限定容器。***组件110可以是完全围绕光学组件120的环形外部隔室,或者***组件110可以是仅围绕光学组件120的一部分延伸的离散的外部分段。***组件110可以具有与光学组件120流体连通的内部容积112。然而,在其他实施例中,***组件110的内部容积112可以与光学组件120的内部流体隔离。***组件110可以比光学组件120更硬。因此,光学组件120中的容积变化要比***组件110中的容积变化大。
光学组件120可以具有耦合至***组件110的前部的前光学元件122,耦合至***组件110的后部的后光学元件124,以及在前光学元件112和后光学元件124之间的流体腔126。前光学元件122可以是第一膜,并且后光学元件124可以是第二膜。第一膜和第二膜可以具有光学度数(例如,具有设定的或最小的曲度),或者它们可以在松弛的无偏状态下不具有光学度数(例如,在图1中为水平的)。流体腔126可以填充有光学流体128,使得前光学元件122,后光学元件124和光学流体限定流体透镜130。在操作中,光学流体128可以填充***组件110和流体腔126,以将期望的曲度赋予前光学元件122和/或后光学元件124,从而将期望的光学度数提供给光学组件120。光学组件120可以具有单一的度数或者它可以是光学度数随着天然眼睛的肌肉的动作而变化的调适性流体透镜。
APIOL 100可以进一步包括第一容积控制元件140和/或第二容积控制元件160。第一容积控制元件140可以是收缩元件或释放元件,其被配置成使用第一无创激活形式排出或释放运送物。相反地,第二容积控制元件160可以是膨胀元件,其被配置成使用第二无创激活形式来吸收或吸引和保留物质。第一和第二无创激活形式可以是一种或多种类型的能量,例如激光辐射,超声能量,射频(RF)能量或红外辐射,其可选择地激活第一和第二容积控制元件140和160中的一个或两个。在一些实施例中,第一无创激活形式仅激活第一容积控制元件140,以及第二无创激活形式仅激活第二容积控制元件160,从而第一和第二容积控制元件140和160可以彼此独立地被激活。例如,第一容积控制元件140可以由一种类型的能量(例如,激光能量)激活,而第二容积控制元件160可以由不同类型的能量(例如,RF能量)激活。在不同的示例中,第一和第二容积控制元件140和160可以通过在不同波长或频率下的共同类型的能量来激活。在这个示例中,第一容积控制元件140可以由在第一波长或频率下的能量类型(例如,第一频宽的激光能量)激活,以及第二容积控制元件160可以由在第二波长或频率下的相同能量类型(例如,第二频宽的激光能量)激活。第二频宽与第一频宽完全不同,以避免第一和第二容积控制元件的连带激活。在其他实施例中,单个无创激活形式可以激活第一容积控制元件140和第二容积控制元件160两者。在激活时,第一和第二容积控制元件140和160可以分别变成第一和第二受激活的元件142和162。
选择光学流体128和运送物(图1中未示出)以相对于天然眼睛的眼房水维持流体腔126内的期望的平衡。选择运送物以经由渗透而运送穿过***组件110,前光学元件122,和/或后光学元件124的壁,以维持在流体腔126中的光学流体128与运送物之间的期望的平衡。在一些实施例中,光学流体128是可以维持溶解水含量大于百分之几的油,并且运送物是水。因此,第一容积控制元件140(例如,收缩元件)在APIOL 100内提供水的来源,而第二容积控制元件160(例如,膨胀元件)提供水槽。当通过激活第一容积控制元件140元件或第二容积控制元件160来改变内部容积时,流体腔126中的物质的容积改变,从而就地调节光学组件120的度数。通常,当流体腔126中的物质的内部容积增加时,光学度数增加,而且相反地,当流体腔126中的物质的内部容积减少时,光学度数减小。
图2示意性地示出了第一容积控制元件140的操作,并且更具体地从第一容积控制元件140释放或排出运送物(例如水)以减小光学组件120的光学度数。在本技术的这个方面,能量源170产生与第一容积控制元件140相互作用的无创激活能量172,使得第一容积控制元件140释放或排出运送物。随着运送物从第一容积控制元件140中被释放,运送物在APIOL 100中的内部流体或光学流体128过饱和。过量运送物穿过***组件110和/或光学组件120的光学元件122,124的壁进入周围的房水。因此,APIOL 100的内部容积减少了从APIOL 100运出的运送物的容积。由于APIOL 100的***组件110在结构上比光学组件120硬,因此光学组件120的容积比***组件110的容积变化大。光学组件120的容积的减少减小了光学组件120的光学度数。
图3示意性地示出了第二容积控制元件160的操作,并且更具体地在第二容积控制元件160中和/或之上吸收或收集运送物(例如,水)以增加光学组件120的光学度数。在本技术的特定示例中,APIOL 100的光学度数通过将水蓄积到第二容积控制元件160中而增加。更具体地,运送物从光学流体被吸收到第二容积控制元件160中,并且第二容积控制元件160膨胀以占据更多的容积。从光学流体中移除的运送物被来自眼房水的相同类型物所替代,该相同类型物从周围的眼房水穿过***组件110和/或光学组件120进入光学流体。这使光学流体的化学性质回到其平衡水平(例如,水:油平衡比)。因此,APIOL 100的内部容积增加了已被APIOL 100内的第二容积控制元件160吸收的水的容积。由于APIOL 100的***组件110在结构上比光学组件120硬,光学组件120的容积增加,从而增加了光学组件120的光学度数。
图4是更详细地示出了光学组件120的多个方面的剖视图。前光学元件122和后光学元件124可以限定APIOL 100的容器或结构部分。如图所示,两个膜在松弛的无偏状态(例如,片状)中都是薄且平坦的,并且在这个状态下不给光学组件120提供光学度数。随着APIOL 100的内部容积增加,膜会弯曲成大致球形的曲度。膜之间的高折射率光学流体128结合光学元件122和124,从而形成具有光学度数的流体透镜130。随着流体腔126中的光学流体128的容积增加,流体透镜130的光学度数增加。在其他实施例中(未示出),前光学元件122和后光学元件124中的一个或两个可以在松弛的无偏状态下具有曲度,使得它们包括光学度数。仍在其他实施例中,前光学元件122或后光学元件124中的一个可以比另一个(未示出)更硬和/或更厚。
图5示出了根据本技术的APIOL 500。APIOL 500类似于上述的APIOL 100,并且类似的附图标记指代类似的组件。APIOL 500与APIOL 100的不同之处在于APIOL 500的***组件110和光学组件120通过屏障510彼此流体隔离。屏障510例如可以是亲水性膜。在这样的实施例中,屏障510约束与第一和/或第二容积控制元件140,160的激活相关的杂物(“D”)进入光学组件120的流体腔126。在一些这样的实施例中,膜510可以在***组件110和光学组件120之间是连续的,如图5所示。而在其他实施例中,膜510可以包含通道或大孔512(以虚线示出),该通道或大孔512防止或抑制杂物D穿入光学组件120同时允许光学流体128穿入/穿出流体腔126。预期该实施例可用于提供一种可调节的调适性流体透镜,其中光学组件120随着天然眼睛作用在***组件110上以将流体泵入或撤出流体腔126而增加/减少光学度数(例如,参见国际申请号[Insert 120974.8012WO00],其通过引用并入本文)。
图6是示出根据本技术的APIOL 600的剖视图,其中光学组件120被可变形屏障610围绕。APIOL600与上述APIOL 100和500类似,并且类似的附图标记指代类似的组件。包括第一和第二容积控制元件140,160的***组件110中的流体作用在可变形屏障610上。在一些实施例中,可变形屏障610是波纹式的。在操作中,光学流体128可具有对水的更标准的低溶解度,并且从第一容积控制元件140释放的水的液泡扩散到与房水连通的***组件110的外表面。
图7是根据本技术的APIOL 700的平面图,其中,相对于图1-6,类似的附图标记指代类似的组件。APIOL 700具有***组件710和在***组件710的中间的光学组件120。***组件710具有包含流体和第一容积控制元件140的第一隔室714,并且***组件710具有包含流体和第二容积控制元件160的第二隔室716。APIOL 700与APIOL 100,500和600的对应的不同之处在于,第一容积控制元件140与第二容积控制元件160隔离,第一容积控制元件140与第二容积控制元件160分别位于第一和第二隔室714和716中。
图8A是根据本技术的APIOL 800的等距视图,以及图8B是沿图8A的截面A-A得到的剖视图。APIOL 800还将第一容积控制元件140与第二容积控制元件160隔离,但是APIOL800使用多个隔室。更具体地,APIOL 800具有完全包围光学组件120的***组件810,并且***组件810具有多个第一隔室814,该多个第一隔室814被配置成包含第一容积控制元件140的单独的容积,以及多个第二隔室816,该多个第二隔室816被配置成包含第二容积控制元件160的单独的容积。APIOL 700和800中的每一个可以在包含容积控制元件的隔室和光学组件120之间具有连接屏障。APIOL 700和800中的每一个可以在包含容积控制元件的隔室和光学组件120之间具有连接屏障。在这样的实施例中,由容积控制元件140,160的激活驱动的连接屏障的变形调整APIOL 700和800的光学组件120的***容积。
第一容积控制元件140可具有薄的外壁和在该薄的外壁中的一定容积的运送物。例如,第一容积控制元件140可具有薄的蜡壳和被包裹在该壳内的少量水。在其他实施例中,第一容积控制元件140可具有被脂质体壳包裹的水,所述脂质体壳例如具有双层脂质外膜的单层脂质体壳。在其他实施例中,第一容积控制元件140可以是闭孔蜡质海绵状体,在该闭孔海绵状体的空隙中有水。
第二容积控制元件160可以包括包裹了亲水材料或可以扩散或穿过光学流体128和/或APIOL的***壁的一部分的材料的疏水材料的外表面。例如,本文描述的第二容积控制元件160可以包括小容积的脱水水凝胶,其包裹在蜡,聚对二甲苯涂层,或两亲材料层的薄层中,使得亲水性头基呈现在水凝胶的外部表面和疏水性尾基向外向环境呈现而形成胶束。第二容积控制元件160也可以是闭孔蜡质海绵状体,其中海绵状体内的孔洞包含水凝胶。
上述的容积控制元件140,160可以通过可控地破坏壳或外部涂层而被激活,从而允许所包含材料的受控的量进入局部环境。这样的能量可以是激光能量,超声,包括RF的电能,和红外能量中的一种或任意组合。在一些实施例中,破坏是通过将激光能量输送到容积控制元件来完成的。在一些实施例中,第一容积控制元件140和第二容积控制元件160由不同波长的激光能量或不同频率的超声或电能激活。例如,第一波长的激光能量用于激活第一容积控制元件140,而第二不同波长的激光能量用于激活第二容积控制元件160。可以通过控制涂层材料的吸收度和/或容积控制元件的尺寸将这样的可选择性内置于容积控制元件中。在替代实施例中,第一和第二容积控制元件140,160可以被分隔开,使得它们可以如以上参考图7,8A和8B所述单独地被处理。
图9A是示出了根据本技术的模块化的APIOL 900的等距视图,图9B是其底部平面图,以及图9C是沿着图9B的截面A-A得到的剖视图。参照图9A和9B,APIOL 900具有调适结构910,固定透镜930,第一容积控制元件140,和第二容积控制元件160。参照图9C,调适结构910例如可以具有限定前部的第一组件911和限定后部的第二组件912。组装第一和第二组件911和912以形成彼此流体连通的外部储液器914,通道916,和内部流体腔918。外部储液器914,通道916和内部流体腔918充满了光学流体和运送物的溶液,它们通过通道916在外部储液器914和内部腔918之间流动。
调适结构910可以具有调适光学元件920(例如,调适流体透镜),该调适光学元件具有限定内部流体腔918的前侧的第一光学组件921和限定内部流体腔918的后侧的第二光学组件922。第一和第二光学组件921和922可以是不具有光学度数的柔性膜,或者在其他实施例中,第一和第二组件921和922中的一个或两者可以是具有光学度数的柔性透镜。在操作中,流体响应于天然眼睛的睫状肌的运动而在外部储液器914和内部腔918之间流动。例如,当睫状肌松弛时,囊膜推压外部储液器914,这继而引起流体流入内部腔918并使第一光学组件921向前弯曲。这增加了调适光学元件920的厚度。相反,当睫状肌收缩时,将囊膜径向向外拉,使得施加在外部储液器914上的力减小,从而允许内部腔918中的高压流体流入外部储液器914。这减小了沿着调适光学元件920的光轴的厚度(例如,曲度)。
APIOL 900包括流通特征950,该流通特征950提高了从天然晶状体囊膜中去除AIOL的植入的过程中使用眼科粘膜外科手术装置(OVD)的速率和便利性。APIOL 900可以具有三个外部流通特征950。外部流通特征950可以是沿外部储液器914的周边周向分布的稳定装置,例如凹部。在所示的实施例中,流通特征950形成在第一和第二组件911和912的区域中。尽管示出了三个外部流通特征950,但是其他实施例可以包括比所示出的更少或更多的外部流通特征。外部流通特征950可以额外地抑制APIOL 900在眼睛中的旋转。
APIOL 900还包括固定透镜组件930。图9C所示的固定透镜组件930包括光学部分932,从光学部分932延伸出的裙部934,以及通道936。光学部分932具有固定度数,其可以包括不对称地提供度数的透镜或如本文中所说明的其他透镜,并且通道936是孔,槽,窍等,其穿过裙部934并且延伸到周界区域,但是不延伸到光学部分932。
参照图9C,固定透镜组件930具有围绕裙部934延伸的配合特征938(例如环形凹槽),并且调适结构910的第一组件911具有加厚区域939,例如径向向内延伸的环形突起(例如壁架)。通过使第一组件910的连续的加厚区域939与固定透镜组件930的配合特征938配合,可以将固定透镜组件930附接到调适结构910。在其他实施形式(未示出)中,加厚区域939和配合特征938可以是不连续的特征(例如,分段的或围绕小于固定透镜组件930和调适结构910的整个圆周延伸的其他凹部或突起)。这种不连续的加厚区域939和配合特征938是被期望的,以在固定透镜组件930与调适结构910之间(例如当固定透镜组件930包括复曲面透镜或其他非对称透镜时)保持特定的径向对准。替代地,凹槽可以在固定透镜组件930中,并且突起可以在调适结构910上。
固定透镜组件930可以在调适部分910被植入之后被植入。预期这是有利的,因为可以植入调适部分910,然后可以基于调适部分910的实际植入后的光学度数选择和再植入具有期望光学度数的固定透镜组件930。固定透镜组件930在被附接到调适结构910之后也可以被移除。如果最初植入的固定透镜组件930在***调适结构910时不正确或已损坏,则这是有利的。
APIOL 900还可以包括正方形的环形区域951,其抑制细胞从患者囊膜的***迁移到APIOL 900的光学部分(在图9C中显示为晶状体的最后部的区域)。这种细胞迁移可能导致光学***的手术后浑浊。
参照图9B和9C,APIOL 900在外部储液器914中包括第一和第二容积控制元件140和160。结果,当第一或第二容积控制元件140或160被激活时,如上所述,APIOL 900在外部储液器914中的物质的容积分别减小或增大。外部储液器914中物质容积的变化相应地改变了调适光学元件920中的容积,这继而如上所述调节了APIOL 900的度数。即使在具有可移除的固定透镜组件930的APIOL 900中,这也期望是有用的。例如,即使固定透镜组件930可以在调适结构910被植入或如果不合适而被移除后进行植入,如果需要的话,也可以激活第一或第二容积控制元件140或160用于进一步调节APIOL 900的光学度数。
图10A是固定透镜1030的底部等距视图,以及图10B是沿着图10A的截面B-B得到的横截面视图。固定透镜1030类似于以上在图9A-9C中描述的模块化调适性APIOL 900中使用的固定透镜930。然而,固定透镜1030包括第一和第二容积控制元件140和160,以替代或补充在容器中具有容积控制元件140和/或160。固定透镜1030本身是可调节度数的透镜。例如,参考图10B,固定透镜1030包括前光学元件1032,后光学元件1034,和填充有光学流体和运送物的流体腔1036。在操作中,第一和/或第二容积控制元件140和/或160暴露于无创激活能量以减小或增大流体腔1036中的物质的容积,从而如上述参照图1-8B调节固定透镜1030的光学度数。
适用于上述光学流体128的油的一个实施例可以通过组合以下材料的容积来混合。可通过改变以下成分的比例来调整水含量和折射率两者的平衡:
苯甲基环硅氧烷(Phenylmethylcyclosiloxane)。RI 1.545
N-(三乙氧基甲硅烷基丙基)-O-聚环氧乙烷氨基甲酸酯(N-(triethoxysilylpropyl)-O-Polyehylene oxide urethane),RI 1.45
(羟基乙烯氧基丙基甲基硅氧烷)-(3,4-二甲氧基苯基丙基)甲基硅氧烷-二甲基硅氧烷三元共聚物((HYDROXYETHYLENEOXYPROPYLMETHYLSILOXANE)-(3,4-DIMETHOXYPHENYLPROPYL)METHYLSILOXANE-DIMETHYLSILOXANE TERPOLYMER),RU 1.505。
Claims (15)
1.可调节度数的眼内透镜,包括:
具有光学组件和围绕至少一部分所述光学组件延伸的***组件的容器,其中所述光学组件具有前光学元件,后光学元件,和流体腔,该流体腔具有在所述前光学元件与所述后光学元件之间的腔室容积;
在所述容器中的光学流体;
在光学流体溶液中的运送物,其中所述运送物被配置成穿透所述容器;以及
在所述容器内的容积控制元件,其中所述容积控制元件被配置成由无创能量激活,并且在激活时将所述运送物释放到所述光学流体中以减小所述腔室容积和/或从所述光学流体中吸收所述运送物以增加所述腔室容积,从而调节所述可调节度数的眼内透镜的度数,
其中,所述无创能量包括激光能量,超声,电能,和/或红外。
2.根据权利要求1所述的可调节度数的眼内透镜,其中所述容积控制元件仅包括第一容积控制元件,所述第一容积控制元件被配置成将所述运送物释放到所述光学流体中以减小所述腔室容积。
3.根据权利要求1所述的可调节度数的眼内透镜,其中所述容积控制元件仅包括第二容积控制元件,所述第二容积控制元件被配置成从所述光学流体中吸收所述运送物以增加所述腔室容积。
4.根据权利要求1所述的可调节度数的眼内透镜,其中所述容积控制元件包括:
第一容积控制元件,该第一容积控制元件被配置成将所述运送物释放到所述光学流体中以减小所述腔室容积;以及
第二容积控制元件,该第二容积控制元件被配置成从所述光学流体中吸收所述运送物以增加所述腔室容积。
5. 根据权利要求4所述的可调节度数的眼内透镜,其中:
所述第一容积控制元件由第一类能量激活;以及
所述第二容积控制元件由不同于所述第一类能量的第二类能量激活。
6.根据权利要求5所述的可调节度数的眼内透镜,其中:
所述第一类能量选自激光能量,超声波能量,电能,和红外能量;以及
所述第二类能量是选自激光能量,超声波能量,电能,和红外能量的不同类型的能量。
7.根据权利要求4所述的可调节度数的眼内透镜,其中:
所述第一容积控制元件由第一波长或频率的能量激活;以及
所述第二容积控制元件由不同于第一波长或频率的第二波长或频率的相同类型的能量激活。
8.根据权利要求7所述的可调节度数的眼内透镜,其中所述能量为激光能量,所述第一波长位于第一频宽内,以及所述第二波长位于所述第一频宽外的第二频宽内。
9.根据权利要求7所述的可调节度数的眼内透镜,其中所述能量为超声波能量,所述第一频率在第一频率范围内,以及所述第二频率在与所述第一频率范围不同的第二频率范围内。
10.根据权利要求7所述的可调节度数的眼内透镜,其中所述能量是射频能量,所述第一频率在第一频率范围内,以及所述第二频率在与所述第一频率范围不同的第二频率范围内。
11.根据权利要求1所述的可调节度数的眼内透镜,其中所述光学流体包括油,以及所述运送物包括水。
12.根据权利要求1所述的可调节度数的眼内透镜,其中:
所述***组件包括外部储液器;
所述光学组件包括与所述***组件流体连通的调适光学组件,并且其中所述光学流体响应于天然眼睛的睫状肌的运动而在所述***组件和所述光学组件之间流动;
所述容积控制元件包括(a)被配置成在激活时释放所述运送物的第一容积控制元件和(b)被配置成在激活时吸收所述运送物的第二容积控制元件。
13.根据权利要求12所述的可调节度数的眼内透镜,其中:
所述光学流体包括油;
所述运送物包括水;
所述第一容积控制元件在激活时被破坏并且将所述运送物释放到所述光学流体中,并且被释放的至少一部分所述运送物穿出所述容器,从而减小了所述流体腔中的物质的容积;以及
所述第二容积控制元件在激活时被破坏并且通过从所述光学流体中吸收所述运送物而扩大,并且来自所述容器外部的额外的运送流体穿入所述容器,从而增加了所述流体腔中的物质的容积。
14.根据权利要求1所述的可调节度数的眼内透镜,其中所述容积控制元件包括:
具有壳和包含在所述壳中的水的第一容积控制元件;以及
具有壳和在所述壳中的脱水水凝胶的第二容积控制元件。
15.根据权利要求14所述的可调节度数的眼内透镜,其中所述壳包括蜡或脂质体。
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AU2018279101B2 (en) | 2023-07-13 |
CA3066081A1 (en) | 2018-12-13 |
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EP3634309A1 (en) | 2020-04-15 |
CN110996850A (zh) | 2020-04-10 |
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EP4205702A1 (en) | 2023-07-05 |
US20200146813A1 (en) | 2020-05-14 |
JP2020523096A (ja) | 2020-08-06 |
WO2018227014A1 (en) | 2018-12-13 |
EP3634309B1 (en) | 2023-05-24 |
EP3634309A4 (en) | 2020-12-16 |
JP7082822B2 (ja) | 2022-06-09 |
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