CN110934147A - Medical ultrasonic disinfection coupling agent and preparation method thereof - Google Patents
Medical ultrasonic disinfection coupling agent and preparation method thereof Download PDFInfo
- Publication number
- CN110934147A CN110934147A CN201811114838.8A CN201811114838A CN110934147A CN 110934147 A CN110934147 A CN 110934147A CN 201811114838 A CN201811114838 A CN 201811114838A CN 110934147 A CN110934147 A CN 110934147A
- Authority
- CN
- China
- Prior art keywords
- medical ultrasonic
- couplant
- ultrasonic
- chitosan
- disinfection
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
- A01N47/44—Guanidine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/04—Oxygen or sulfur attached to an aliphatic side-chain of a carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
- A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a medical ultrasonic disinfection coupling agent, which comprises the following components in percentage by weight: 0.03-0.1% of chlorhexidine gluconate, 0.002-0.01% of terpineol, 0.1-0.5% of chitosan, 10-20% of wetting agent, 0.8-1.6% of distearyl alcohol polyether, 0.08-0.15% of preservative and the balance of purified water. The invention also discloses a preparation method of the medical ultrasonic disinfection couplant. The medical ultrasonic disinfection couplant is colorless, nontoxic, non-irritant, appropriate in viscosity, good in conductivity, less in ultrasonic energy loss, high in resolution, clear in ultrasonic imaging, high in safety, efficient, rapid and durable in disinfection and skin moistening, can disinfect an ultrasonic probe at any time while sterilizing, and avoids cross infection in clinical examination. In addition, the medical ultrasonic disinfection couplant has the advantages of wide raw material source, simple preparation process, low cost and easy market popularization and application.
Description
Technical Field
The invention belongs to the technical field of medical disinfection, and particularly relates to a medical ultrasonic disinfection coupling agent.
Background
The medical ultrasonic coupling agent is one of the most frequently used materials in clinic, has the characteristics of harmlessness to human bodies, no stimulation or anaphylactic reaction to skin, easy erasing, good thixotropy, no flowing, easy control of operation, difficult drying, difficult rancidity, clear ultrasonic imaging, proper viscosity, no oil, easy sliding of a probe, moistening of the skin, elimination of air on the surface of the skin, good lubricating property and easy unfolding; the most important thing is that during ultrasonic examination, the ultrasonic couplant fills the tiny gaps between the probe and the contact surface, so that the tiny air in the gaps does not influence ultrasonic penetration, and the acoustic impedance difference between the probe and the skin is reduced, thereby reducing the reflection loss of ultrasonic energy on the interface and improving the definition and resolution of pictures; the ultrasonic probe is not corroded and damaged and achieves the disinfection effect.
In the ultrasonic diagnosis and treatment process, the in-vitro ultrasonic probe and the coupling agent directly contact the skin and the cavity mucosa of a patient, even can contact open wounds, ulcers, a flow guide pipe and some equipment for maintaining vital signs of the patient, and are easy to cause cross infection; at present, the medical ultrasonic disinfection couplants in the market are more in variety, for example, Chinese patent CN105983107A provides a novel medical disinfection and sterilization ultrasonic couplant, magnolol is used as a main sterilization component, syringic acid, anisic acid, dipotassium glycyrrhizinate and vanillin are used for synergistic sterilization, and researchers show that the plant extracts can only achieve an anti-bacterial effect and cannot achieve rapid sterilization; for example, Chinese patent CN104189927A realizes the sterilization effect by compounding 6 Chinese herbal medicine essential oils, the mixed odors of the Chinese herbal medicine essential oils are mixed, a closed B-ultrasonic room is inconvenient to frequently use, and the preparation process is complex; and if the chemical components are taken as bactericides: chinese patent CN101249268A takes one or a combination of (0.05% -0.15%) polyhexamethylene biguanide, benzalkonium chloride, benzalkonium bromide, chlorhexidine acetate, trichlorophenoxy diphenyl ether and nano-silver as a bactericidal component; the Chinese patent CN101219223A takes (0.2% -2%) 2,4, 4-trichloro-2-hydroxydiphenyl ether as a bactericidal component, can not be biodegraded, has more chemical bactericide addition amount, and has certain stimulation effect on skin after ultrasonic diagnosis.
Disclosure of Invention
Aiming at the defects of the existing medical disinfection ultrasonic couplant, the embodiment of the invention hopes to provide the medical ultrasonic disinfection couplant which has the advantages of high-efficiency sterilization effect, no corrosion and swelling to a medical ultrasonic probe, no toxicity to a human body, no sensitization, no stimulation to skin, good conductivity, less ultrasonic energy loss, high resolution and clear ultrasonic imaging, and is used as the couplant in the detection process. The medical ultrasonic disinfection couplant can disinfect an ultrasonic probe at any time while sterilizing, is convenient to use, effectively avoids clinical cross infection, is simple in manufacturing process, and does not need processes of vacuumizing, bubble removing and the like. In addition, the invention also aims to provide a preparation method of the medical ultrasonic disinfection couplant.
Aiming at the defects of the existing medical disinfection ultrasonic coupling agent, the invention screens proper natural high molecular polymer chitosan and plant essential oil extract terpineol by a small amount of chemical additive chlorhexidine gluconate to achieve the optimal synergistic bactericidal action, has the bactericidal rate of more than 99.999 percent on staphylococcus aureus, escherichia coli, candida albicans and the like, has the cleaning and disinfecting effects on ultrasonic probes and inspected skin before and after inspection, has no damage to any article, no short-term or long-term toxicity on organisms, no residue in the environment, biodegradability, comfortable feeling when contacting human bodies, no stimulation to skin mucous membranes of human skins, no sensitization, no damage to probes, good conductivity, less ultrasonic energy loss, high resolution, clear ultrasonic imaging, high safety, high efficiency, rapidness, durable disinfection and skin moistening, effectively avoids cross infection in clinical examination.
According to an embodiment, the medical ultrasonic disinfection couplant provided by the invention comprises the following components in percentage by weight:
preferably, in the medical ultrasonic disinfection couplant, the chitosan is low-molecular chitosan, and the molecular weight of the chitosan is less than 10000.
Preferably, the distearyl alcohol polyether is a nonionic water-soluble gelling agent.
Preferably, the medical ultrasonic disinfection couplant comprises chlorhexidine gluconate, terpineol and chitosan in a weight ratio of 1: 0.05-0.1: 3-5.
Preferably, the medical ultrasonic disinfection couplant comprises one or two of glycerin and propylene glycol as wetting agents.
Preferably, the medical ultrasonic disinfection couplant is prepared by using one or two of methyl p-hydroxybenzoate, propyl p-hydroxybenzoate, ethyl p-hydroxybenzoate and butyl p-hydroxybenzoate as preservative.
In the invention, the purified water is prepared according to the requirements of Chinese pharmacopoeia.
According to the embodiment, the preparation method of the medical ultrasonic disinfection couplant provided by the invention comprises the following steps:
(1) weighing distearyl alcohol polyether according to the proportion, adding a proper amount of purified water, stirring and dissolving at the temperature of 60-70 ℃ for 30-40min until the mixture becomes transparent colloid, thus obtaining the system A.
(2) And adding the chlorhexidine gluconate, the terpineol, the chitosan and the preservative into the wetting agent in proportion, and uniformly stirring until the mixture is completely dissolved to obtain a system B.
(3) Under the condition of stirring, adding the system B into the system A, uniformly stirring, adding the rest purified water, and uniformly mixing to obtain the medical ultrasonic disinfection couplant.
Compared with the prior art, the chlorhexidine gluconate and natural high molecular polymer chitosan are compounded with a small amount of chemical addition, and the optimal disinfection effect is achieved through the synergistic effect of the chlorhexidine gluconate, the natural high molecular polymer chitosan and the plant essential oil terpineol. The chlorhexidine gluconate can rapidly and durably sterilize, has quite strong broad-spectrum antibacterial and bactericidal effects, and is effective on gram-positive bacteria and gram-negative bacteria. According to the method of 'disinfection technical specification' of 2002 edition, a plurality of toxicological research experiments prove that the oral toxicity of chlorhexidine gluconate with common concentration is non-toxic, no stimulation is caused to skin and vaginal mucosa, the results of mouse bone marrow multiple red cell micronucleus test and subacute toxicity test are negative, namely the chlorhexidine gluconate has good safety as a disinfectant; the low molecular chitosan is a natural positively charged high molecular polymer killed in nature, is derived from a natural chitosan derivative, has a molecular weight of less than 10000, has good antibacterial and bactericidal properties and good biocompatibility, is non-toxic, biodegradable and very environment-friendly; the terpineol is plant essential oil extracted from plant oil, and the disinfectant derived from plants can effectively disinfect an ultrasonic probe, can enable the skin of a patient to meet the disinfection requirement, and achieves the purpose of disinfecting the medical ultrasonic probe and the skin of the patient at the same time.
The invention firstly utilizes the amino group in the chitosan molecular structure to react with the cell membrane with negative charges of bacteria, so that the cell membrane function of the bacteria is disordered, the cell membrane permeability is changed, and the bacterial production on skin and an ultrasonic probe is inhibited; secondly, the plant essential oil extract terpineol is utilized to penetrate cell walls and destroy polysaccharides on the cell walls, so that the bacteria surface is exposed and loses the protection effect and finally die; and finally, the chlorhexidine gluconate is used to kill harmful bacteria on the skin and the ultrasonic probe together with the terpineol, so that the cross contamination of clinical examination is effectively prevented. The invention also selects a non-ionic water-soluble high molecular polymer as a thickening agent, avoids incompatibility of crosslinked polyacrylic resin and sodium alginate anionic thickening agent, can be compatible with the selected disinfectant to form water-soluble gel with higher transparency, ensures good stability of compatibility and has good acoustic performance.
The medical ultrasonic disinfection couplant has the advantages of high-efficiency sterilization effect, no corrosion and swelling to a medical ultrasonic probe, no toxicity to a human body, no sensitization effect, no stimulation to skin, good conductivity, less ultrasonic energy loss, high resolution, clear ultrasonic imaging, sterilization, convenient use, effective avoidance of clinical cross infection, simple manufacturing process, no need of processes of vacuumizing, bubble removal and the like, and can be used as a couplant in a detection process.
Detailed Description
The invention will be further illustrated with reference to the following specific examples. These examples are to be construed as merely illustrative and not limitative of the remainder of the disclosure in any way whatsoever. After reading the description of the invention, one skilled in the art can make various changes and modifications to the invention, and such equivalent changes and modifications also fall into the scope of the invention defined by the claims.
Example 1
(1) 0.9g of distearyl alcohol polyether is weighed, 86g of purified water is added, and stirring and dissolving are carried out at the temperature of 65 ℃ for 35min, so as to obtain a transparent colloid A system.
(2) 0.05g of chlorhexidine gluconate, 0.008g of terpineol, 0.2g of chitosan, 0.06g of ethyl p-hydroxybenzoate and 0.03g of propyl p-hydroxytoluene are weighed and added into 12g of propylene glycol to be uniformly stirred until the materials are completely dissolved, so as to obtain a system B.
(3) And under the condition of stirring, adding the system B into the system A, uniformly stirring, supplementing purified water to 100g, and uniformly mixing to obtain the medical ultrasonic disinfection couplant.
Example 2
(1) 1.2g of distearyl alcohol polyether is weighed, 83g of purified water is added, and stirring and dissolving are carried out at the temperature of 65 ℃ for 35min to obtain a transparent colloid A system.
(2) 0.1g of chlorhexidine gluconate, 0.003g of terpineol, 0.3g of chitosan, 0.05g of methyl p-hydroxybenzoate and 0.04g of ethyl p-hydroxytoluene are weighed and added into 15g of glycerol to be uniformly stirred until the materials are completely dissolved, so as to obtain a system B.
(3) And under the condition of stirring, adding the system B into the system A, uniformly stirring, supplementing purified water to 100g, and uniformly mixing to obtain the medical ultrasonic disinfection couplant.
Example 3
(1) 1.0g of distearyl alcohol polyether is weighed, 84g of purified water is added, and stirring and dissolving are carried out for 35min at the temperature of 65 ℃, so as to obtain a transparent colloid A system.
(2) 0.08g of chlorhexidine gluconate, 0.004g of terpineol, 0.1g of chitosan and 0.105g of methyl p-hydroxybenzoate are weighed and added into 6g of propylene glycol and 8g of glycerol to be uniformly stirred until the materials are completely dissolved, so as to obtain a system B.
(3) And under the condition of stirring, adding the system B into the system A, uniformly stirring, supplementing purified water to 100g, and uniformly mixing to obtain the medical ultrasonic disinfection couplant.
Example 4
(1) 1.5g of distearyl alcohol polyether is weighed, 81g of purified water is added, and stirring and dissolving are carried out at the temperature of 65 ℃ for 35min, so as to obtain a transparent colloid A system.
(2) 0.03g of chlorhexidine gluconate, 0.01g of terpineol, 0.4g of chitosan and 0.1g of butyl p-hydroxybenzoate are weighed and added into 16g of propylene glycol to be uniformly stirred until the mixture is completely dissolved, so as to obtain a system B.
(3) Under the condition of stirring, adding the system B into the system A, uniformly stirring, supplementing purified water to 100g, and uniformly mixing to obtain the medical ultrasonic disinfection couplant.
Test example 1
According to item 2.1.1 of the 2002 edition of the sanitation department of the people's republic of China, the medical ultrasonic disinfection coupling agent prepared in the embodiment 1-4 is used for a sterilization test, under the action time of 1min, the sterilization rate of staphylococcus aureus, candida albicans, escherichia coli, pseudomonas aeruginosa and the like reaches more than 99.999 percent, and the specific data are shown in the following table 1; the couplant is smeared on an ultrasonic probe for 2min and then detected, and the sterilization rate of staphylococcus aureus, candida albicans, escherichia coli, pseudomonas aeruginosa and the like reaches 99.999 percent.
TABLE 1 bacteria killing test of medical ultrasonic disinfection couplant prepared in four examples
Test example 2
The medical ultrasonic disinfection coupling agent prepared in the example 1-4 is used for carrying out acute oral toxicity test on mice according to item 2.3.1 of the disinfection technical Specification of 2002 edition of Ministry of public health of the people's republic of China, after the mice are infected with the virus, the poisoning expression and the death condition of the mice are observed, the observation time is 14d, and the dead animals and the animals killed after the observation period are roughly dissected. After the result is infected, no abnormal expression and death of experimental mice appear, no obvious abnormal change is seen in gross anatomy of animals killed after the observation period, and the test object male and female sexually-used mice acute oral LD50All are more than 5.0/kg body weight, and belong to actual non-toxicity according to acute toxicity classification standards.
Test example 3
The medical ultrasonic disinfection couplant prepared in the embodiment 1-4 is taken, a complete skin irritation test and a disposable damaged skin irritation test are carried out according to item 2.3.3 of the 2002 edition of the sanitation Specification of the Ministry of the people's republic of China, the local skin reactions are respectively observed for 1h, 24h and 48h after the test substances are removed, and the skin irritation reaction scoring and the irritation intensity grading are respectively carried out according to the 2002 edition of the sanitation Specification of the ministry of health 2-11 and 2-12. The experimental result shows that the integral mean value of the highest skin irritation reaction of the rabbits at each observation point of the once-through complete skin irritation experiment of the medical ultrasonic disinfection couplant prepared in the 4 embodiments is 0, and the couplant is nonirritating; the maximum integral value of skin irritation reaction of rabbits at each observation point in the one-time damaged skin irritation experiment of the medical ultrasonic disinfection couplant prepared in the above 4 embodiments is 0, and the couplant is nonirritating.
Test example 4
The medical ultrasonic disinfection couplant prepared in the embodiment 1-4 is used for an ultrasonic probe field simulation experiment, has no corrosion to the probe and clear image, and can be used for detecting the main performance: the acoustic resistance (35 ℃) is 1520-visco-1620 m/s, and the specific acoustic impedance (35 ℃) is 1.5 multiplied by 106-1.7×106Pas/m, sound attenuation (35 ℃) less than or equal to 0.05DB/(cm.MHZ), viscosity (35 ℃) more than or equal to 15 and pH value between 6 and 7, and the indexes show that the medical ultrasound prepared in the above examples 1 to 4The disinfection couplant meets the standard value of national medical ultrasonic couplant.
In summary, the medical ultrasonic disinfection couplant provided by the invention combines a small amount of chemical additives with natural high molecular polymer and plant essential oil extract in an optimal proportion to achieve an optimal sterilization effect. The couplant has the advantages of high-efficiency broad-spectrum sterilization effect, no corrosivity and swelling to medical ultrasonic probes, no toxicity to human bodies, no sensitization, no stimulation to skin, good conductivity, less loss of ultrasonic energy, high resolution, clear ultrasonic imaging, disinfection of the ultrasonic probes at any time while sterilization, convenience in use, effective avoidance of clinical cross infection, simple manufacturing process, no need of processes of vacuumizing, bubble removal and the like, low cost, and good market prospect and popularization and application value.
Claims (7)
1. The medical ultrasonic disinfection couplant is characterized by comprising the following components in percentage by weight:
2. the medical ultrasonic disinfection couplant of claim 1, wherein: the chitosan is low molecular chitosan, and the molecular weight of the chitosan is less than 10000.
3. The medical disinfectant couplant of claim 1, wherein: the distearyl alcohol polyether is a nonionic water-soluble gel.
4. The medical ultrasonic disinfection couplant of claim 1, wherein: the chlorhexidine gluconate, the terpineol and the chitosan are mixed according to the weight ratio of 1: 0.05-0.1: 3-5.
5. The medical ultrasonic disinfection couplant of claim 1, wherein: the wetting agent is one or two of glycerin or propylene glycol.
6. The medical ultrasonic disinfection couplant of claim 1, wherein: the preservative is one or two of methyl p-hydroxybenzoate, propyl p-hydroxybenzoate, ethyl p-hydroxybenzoate and butyl p-hydroxybenzoate.
7. A preparation method of medical ultrasonic disinfection couplant is characterized by comprising the following steps: the method comprises the following steps:
(1) weighing distearyl alcohol polyether according to the proportion, adding a proper amount of purified water, stirring and dissolving at the temperature of 60-70 ℃ for 30-40min until the distearyl alcohol polyether becomes transparent colloid to obtain a system A;
(2) adding chlorhexidine gluconate, terpineol, chitosan and antiseptic in proportion into wetting agent in proportion, and stirring to dissolve completely to obtain system B;
(3) under the condition of stirring, adding the system B into the system A, uniformly stirring, adding the rest purified water, and uniformly mixing to obtain the medical ultrasonic disinfection couplant.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811114838.8A CN110934147A (en) | 2018-09-25 | 2018-09-25 | Medical ultrasonic disinfection coupling agent and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811114838.8A CN110934147A (en) | 2018-09-25 | 2018-09-25 | Medical ultrasonic disinfection coupling agent and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110934147A true CN110934147A (en) | 2020-03-31 |
Family
ID=69904454
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811114838.8A Withdrawn CN110934147A (en) | 2018-09-25 | 2018-09-25 | Medical ultrasonic disinfection coupling agent and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110934147A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113667193A (en) * | 2021-08-26 | 2021-11-19 | 北京化工大学 | Medical ultrasonic probe antibacterial isolation sleeve and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102107013A (en) * | 2011-01-28 | 2011-06-29 | 武汉耦合医学科技有限责任公司 | Sterile ultrasound gel for invasive ultrasound diagnosis and treatment and preparation method thereof |
| CN102626524A (en) * | 2012-05-04 | 2012-08-08 | 江西中兴汉方药业有限公司 | Chitosan gynaecologic antibacterial gel and preparation method thereof |
| CN106540281A (en) * | 2016-12-08 | 2017-03-29 | 邓丽萍 | B ultrasonic couplant and its preparation technology |
-
2018
- 2018-09-25 CN CN201811114838.8A patent/CN110934147A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102107013A (en) * | 2011-01-28 | 2011-06-29 | 武汉耦合医学科技有限责任公司 | Sterile ultrasound gel for invasive ultrasound diagnosis and treatment and preparation method thereof |
| CN102626524A (en) * | 2012-05-04 | 2012-08-08 | 江西中兴汉方药业有限公司 | Chitosan gynaecologic antibacterial gel and preparation method thereof |
| CN106540281A (en) * | 2016-12-08 | 2017-03-29 | 邓丽萍 | B ultrasonic couplant and its preparation technology |
Non-Patent Citations (1)
| Title |
|---|
| 张流波等: "《医药消毒学最新进展》", 31 December 2015, 人民军医出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113667193A (en) * | 2021-08-26 | 2021-11-19 | 北京化工大学 | Medical ultrasonic probe antibacterial isolation sleeve and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2011247315B2 (en) | Deformable mass for disinfecting surfaces, based on cross-linked hydropropylated polygalactomannan | |
| KR101990185B1 (en) | Antibacterial medical ultrasonic coupling agent and preparation method thereof | |
| CN105746562A (en) | Liquid disinfectant | |
| CN111437206A (en) | Antibacterial and disinfectant hand sanitizer containing nano-silver and preparation method thereof | |
| CN103356999B (en) | Novel marine organism washing-free disinfection solution and its application | |
| CN104667304A (en) | Ultrasonic coupling agent and preparation method thereof | |
| CN111671709A (en) | Tea tree essential oil and ethanol double-disinfection and washing-free hand sanitizer and preparation method thereof | |
| CN107158414A (en) | A kind of antibacterial skin-moisturizing medical ultrasonic coupling agent of disinfection and preparation method thereof | |
| CN110934147A (en) | Medical ultrasonic disinfection coupling agent and preparation method thereof | |
| CN104666285A (en) | Anti-allergic disposable quick-drying hand cleaner of sodium gualenate | |
| CN113209003A (en) | Biological type hand-washing-free antibacterial gel, preparation method and application | |
| WO2008061375A1 (en) | Antiseptic | |
| JPH0769956A (en) | Glutaraldehyde composition | |
| CN111671816A (en) | Plant type no-clean antibacterial disinfectant and preparation method thereof | |
| CN104069070A (en) | Povidone-iodine powder with effective sterilization and disinfection effects and preparation method thereof | |
| CN111329827A (en) | Long-acting antibacterial disinfection wet tissue | |
| CN110585450A (en) | Medical disinfection sterilization type ultrasonic coupling agent | |
| CN104026148B (en) | A kind of virus inactivating agent and production technology thereof | |
| CN101797391B (en) | Disposable bactericidal medical ultrasonic couplant and preparation method thereof | |
| CN107638573B (en) | Antibacterial medical ultrasonic coupling agent and preparation method thereof | |
| CN114632017A (en) | Hand disinfectant for inactivating coronavirus and preparation method thereof | |
| CN109289059B (en) | Sterilizing medical ultrasonic coupling agent and preparation method thereof | |
| CN101711882B (en) | Medical ultrasound coupling agent with function of fast and efficient sterilization and device thereof | |
| KR101862628B1 (en) | A composition of skin lubicant preparation and the method therefor | |
| CN113069561A (en) | Medical ultrasonic coupling agent with disinfection function and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20200331 |