CN111437206A - Antibacterial and disinfectant hand sanitizer containing nano-silver and preparation method thereof - Google Patents
Antibacterial and disinfectant hand sanitizer containing nano-silver and preparation method thereof Download PDFInfo
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- CN111437206A CN111437206A CN202010462405.2A CN202010462405A CN111437206A CN 111437206 A CN111437206 A CN 111437206A CN 202010462405 A CN202010462405 A CN 202010462405A CN 111437206 A CN111437206 A CN 111437206A
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- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 title claims abstract description 47
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 41
- 239000000645 desinfectant Substances 0.000 title claims abstract description 34
- 238000002360 preparation method Methods 0.000 title abstract description 9
- 239000004094 surface-active agent Substances 0.000 claims abstract description 13
- 239000002245 particle Substances 0.000 claims abstract description 10
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 9
- 239000002738 chelating agent Substances 0.000 claims abstract description 8
- 239000002904 solvent Substances 0.000 claims abstract description 8
- 239000002562 thickening agent Substances 0.000 claims abstract description 8
- 239000003755 preservative agent Substances 0.000 claims abstract description 7
- 230000002335 preservative effect Effects 0.000 claims abstract description 7
- 230000003020 moisturizing effect Effects 0.000 claims abstract description 3
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 15
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 15
- 230000002421 anti-septic effect Effects 0.000 claims description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 9
- 238000003756 stirring Methods 0.000 claims description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 7
- 238000010438 heat treatment Methods 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 6
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 claims description 6
- 229940073507 cocamidopropyl betaine Drugs 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- -1 sodium fatty alcohol Chemical class 0.000 claims description 6
- 230000032683 aging Effects 0.000 claims description 5
- 239000003906 humectant Substances 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 5
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims description 4
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 4
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 4
- 238000001816 cooling Methods 0.000 claims description 4
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 4
- 239000000194 fatty acid Substances 0.000 claims description 4
- 229930195729 fatty acid Natural products 0.000 claims description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 4
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 4
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
- 239000001509 sodium citrate Substances 0.000 claims description 4
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 4
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 3
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 claims description 3
- 229920001661 Chitosan Polymers 0.000 claims description 3
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 3
- 229930182478 glucoside Natural products 0.000 claims description 3
- 235000011187 glycerol Nutrition 0.000 claims description 3
- 239000000787 lecithin Substances 0.000 claims description 3
- 235000010445 lecithin Nutrition 0.000 claims description 3
- 229940067606 lecithin Drugs 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 229940051841 polyoxyethylene ether Drugs 0.000 claims description 3
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 3
- 239000011780 sodium chloride Substances 0.000 claims description 3
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 claims description 3
- 238000005303 weighing Methods 0.000 claims description 3
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 claims description 2
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims description 2
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 2
- FPVVYTCTZKCSOJ-UHFFFAOYSA-N Ethylene glycol distearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCOC(=O)CCCCCCCCCCCCCCCCC FPVVYTCTZKCSOJ-UHFFFAOYSA-N 0.000 claims description 2
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 2
- 229920002125 Sokalan® Polymers 0.000 claims description 2
- 235000019270 ammonium chloride Nutrition 0.000 claims description 2
- 229940106189 ceramide Drugs 0.000 claims description 2
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 claims description 2
- 235000019864 coconut oil Nutrition 0.000 claims description 2
- 239000003240 coconut oil Substances 0.000 claims description 2
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims description 2
- 150000004665 fatty acids Chemical class 0.000 claims description 2
- 239000004310 lactic acid Substances 0.000 claims description 2
- 235000014655 lactic acid Nutrition 0.000 claims description 2
- 239000010445 mica Substances 0.000 claims description 2
- 229910052618 mica group Inorganic materials 0.000 claims description 2
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 claims description 2
- 239000004584 polyacrylic acid Substances 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 239000001103 potassium chloride Substances 0.000 claims description 2
- 235000011164 potassium chloride Nutrition 0.000 claims description 2
- 239000011734 sodium Substances 0.000 claims description 2
- 229910052708 sodium Inorganic materials 0.000 claims description 2
- 235000002639 sodium chloride Nutrition 0.000 claims description 2
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 2
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 2
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims 1
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 14
- 241000894006 Bacteria Species 0.000 abstract description 12
- 208000015181 infectious disease Diseases 0.000 abstract description 8
- 201000010099 disease Diseases 0.000 abstract description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 7
- 241000233866 Fungi Species 0.000 abstract description 5
- 241000282414 Homo sapiens Species 0.000 abstract description 5
- 206010059866 Drug resistance Diseases 0.000 abstract description 4
- 241000700605 Viruses Species 0.000 abstract description 4
- 244000052616 bacterial pathogen Species 0.000 abstract description 4
- 230000001954 sterilising effect Effects 0.000 abstract description 4
- 239000003242 anti bacterial agent Substances 0.000 abstract description 3
- 239000003814 drug Substances 0.000 abstract description 3
- 229940079593 drug Drugs 0.000 abstract description 3
- 230000035699 permeability Effects 0.000 abstract description 3
- 239000012466 permeate Substances 0.000 abstract description 3
- 239000011148 porous material Substances 0.000 abstract description 3
- 230000001681 protective effect Effects 0.000 abstract description 3
- 206010011409 Cross infection Diseases 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 230000000249 desinfective effect Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- OSDLLIBGSJNGJE-UHFFFAOYSA-N 4-chloro-3,5-dimethylphenol Chemical compound CC1=CC(O)=CC(C)=C1Cl OSDLLIBGSJNGJE-UHFFFAOYSA-N 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 239000000460 chlorine Substances 0.000 description 2
- 229910052801 chlorine Inorganic materials 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 230000000474 nursing effect Effects 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 239000000344 soap Substances 0.000 description 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 125000005233 alkylalcohol group Chemical group 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000002888 effect on disease Effects 0.000 description 1
- 238000011841 epidemiological investigation Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
Abstract
The invention relates to an antibacterial and disinfectant hand sanitizer containing nano-silver and a preparation method thereof, wherein the hand sanitizer is prepared from the following components in percentage by mass: 0.0005 to 0.05 percent of nano-silver antibacterial disinfectant, 10 to 25 percent of surfactant, 1 to 3 percent of moisturizing factor, 1 to 4 percent of thickening agent, 0.5 to 1 percent of pearling agent, 1 to 2 percent of pH regulator, 0.3 to 0.5 percent of chelating agent, 0.05 to 0.2 percent of preservative and 64.25 to 86.1495 percent of solvent. Therefore, a plurality of germs harmful to human bodies can be killed within a few minutes by the nano silver particles with powerful sterilization and disinfection; meanwhile, the antibacterial agent has strong permeability, can quickly permeate into the pores for sterilization, has good protective effect on infection caused by common bacteria, stubborn bacteria, drug-resistant bacteria, fungi and viruses, effectively prevents the spread of diseases and infection, has broad-spectrum antibacterial and disinfection and does not have any drug resistance.
Description
Technical Field
The invention belongs to the technical field of daily washing and nursing, and particularly relates to an antibacterial and disinfectant hand sanitizer containing nano-silver and a preparation method thereof.
Background
Some diseases of human beings are caused by the fact that hands are contacted with pathogenic microorganisms such as bacteria and viruses, so hand disinfection and cleaning are very important and are effective measures for preventing the spread of germs. The routine hand washing is the most effective and simple and feasible method for controlling the spread of diseases and preventing infection, and has good prevention effect on diseases spread by the digestive tract and diseases spread by the respiratory tract. And extensive epidemiological investigations have confirmed that hands are an important route to nosocomial infections. The medical staff has serious hand pathogen contamination after nursing and diagnosis activities, hospital infection can be directly or indirectly transmitted through the hands of the medical staff, and the way is more dangerous than air transmission, so that the infected people account for 30 percent of the incidence rate of the hospital infection due to bacterial transmission.
The hand sanitizer is an article for cleaning hand skin, and certain specific components can play a role in disinfection and sterilization, and mainly comprise chlorine-containing disinfectants, such as Parachlorometaxylenol (PCMX). However, the chlorine-containing disinfectant has certain residual toxicity and also pollutes the environment.
Disclosure of Invention
In order to solve the problems in the prior art, the invention provides the nano-silver-containing antibacterial and disinfectant hand sanitizer which has strong sterilization and disinfection effects, can basically kill most of bacteria and fungi in a short time, effectively prevent the spread of diseases and prevent infection, and the preparation method of the nano-silver-containing antibacterial and disinfectant hand sanitizer.
In order to solve the technical problems, the invention adopts the following technical scheme:
an antibacterial and disinfectant hand sanitizer containing nano-silver is prepared from the following components in percentage by mass: 0.0005 to 0.05 percent of nano-silver antibacterial disinfectant, 10 to 25 percent of surfactant, 1 to 3 percent of moisturizing factor, 1 to 4 percent of thickening agent, 0.5 to 1 percent of pearling agent, 1 to 2 percent of pH regulator, 0.3 to 0.5 percent of chelating agent, 0.05 to 0.2 percent of preservative and 64.25 to 86.1495 percent of solvent.
Furthermore, the particle size of the nano-silver particles of the nano-silver antibacterial disinfectant is 10-80 nm.
Further, the surfactant is one or more of sodium dodecyl sulfate, α -sulfo fatty acid ester, sodium fatty alcohol polyoxyethylene ether sulfate, cocamidopropyl betaine, lecithin, alkyl glucoside 1214 and coconut oil fatty acid diethanolamide.
Further, the humectant is one or more of glycerin, propylene glycol, polyethylene glycol, sodium hyaluronate and ceramide.
Further, the thickening agent is one or more of polyvinylpyrrolidone, polyvinyl alcohol, polyacrylic acid, sodium chloride, ammonium chloride and potassium chloride.
Further, the pearling agent is one of shell powder, mica powder, ethylene glycol monostearate and ethylene glycol distearate.
Further, the pH regulator is one of citric acid, sodium citrate and lactic acid.
Further, the chelating agent is one of disodium ethylene diamine tetraacetate, tetrasodium ethylene diamine tetraacetate and sodium citrate.
Further, the preservative is chitosan, and the solvent is pure water.
A preparation method of an antibacterial and disinfectant hand sanitizer containing nano-silver specifically comprises the following steps:
a1. weighing the components according to the proportion;
a2. pouring a part of solvent into a container, adding the surfactant into the container, and heating while stirring until the surfactant is completely dissolved;
a3. adding the humectant, the pearling agent, the chelating agent, the preservative and the nano-silver antibacterial disinfectant into a container, heating and stirring the mixture until the mixture is uniformly dispersed, pouring the residual pure water into the container, and cooling the container to room temperature;
a4. respectively adding a pH regulator and a thickening agent into a container, and adjusting the pH value and the viscosity;
a5. dissolving the mixed liquid in the dissolver by using ultrasonic, removing bubbles, and aging to prepare the antibacterial and disinfectant hand sanitizer containing nano silver.
The invention mainly has the following beneficial effects:
by adopting the technical scheme, the nano-silver-containing antibacterial and disinfectant hand sanitizer has strong sterilization and disinfection effect and can kill various germs harmful to human bodies within several minutes; meanwhile, the antibacterial agent has strong permeability, can quickly permeate into the pores for sterilization, has good protective effect on infection caused by common bacteria, stubborn bacteria, drug-resistant bacteria, fungi and viruses, effectively prevents the spread of diseases and infection, has broad-spectrum antibacterial and disinfection and does not have any drug resistance.
Drawings
Fig. 1 is a schematic flow chart of a preparation method of the antibacterial and disinfectant hand sanitizer containing nano silver in embodiment 1 of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is described in further detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
The nano silver antibacterial disinfectant can be used for efficient and rapid antibacterial disinfection and is non-toxic and harmless, the particle size of nano silver particles of the nano silver antibacterial disinfectant is 10-80 nm, the surfactant is non-toxic and harmless and has no harm to a body, the cleaning capability is good, the irritation to hands is low, for example, the surfactant is sodium dodecyl sulfate (K12), α -sulfofatty acid ester (MES), fatty alcohol polyoxyethylene ether sodium sulfate (AES), cocamidopropyl betaine (CAB), lecithin, alkyl alcohol ether (CAB), polyvinyl alcohol (APEA), polyvinyl alcohol sulfate (PVA), polyvinyl alcohol acetate (PVA-EDTA), polyvinyl alcohol (PVA-EDTA-AA), polyvinyl alcohol (PVA-EDTA), polyvinyl alcohol acetate (PVA-EDTA), polyvinyl alcohol (PVA-EDTA-AA), polyvinyl alcohol (PVA-EDTA-AA), polyvinyl alcohol (PVA-EDTA-AA), polyvinyl alcohol (PVA-AA), polyvinyl alcohol, PVA-AA), polyvinyl alcohol (PVA-AA), sodium chloride.
As shown in fig. 1, the preparation method of the antibacterial and disinfectant hand sanitizer containing nano silver, provided by the invention, specifically comprises the following steps:
The nano-silver-containing antibacterial and disinfecting hand sanitizer has high-efficiency antibacterial and disinfecting performance by adopting the nano-silver antibacterial disinfectant containing nano-silver particles, can keep high-efficiency antibacterial and disinfecting effect at low concentration, can ensure no harm to human bodies, and cannot generate drug resistance; the method specifically comprises the following steps: the nano silver particles can kill various germs harmful to human bodies within several minutes by strong sterilization and disinfection; meanwhile, the antibacterial agent has strong permeability, can quickly permeate into the pores for sterilization, has good protective effect on the infection caused by common bacteria, stubborn bacteria, drug-resistant bacteria, fungi and viruses, and has broad-spectrum antibacterial disinfection without any drug resistance.
The antibacterial and disinfectant hand sanitizer containing nano silver and the preparation method thereof are further described by the following embodiments.
Example 1
Taking 100g of prepared antibacterial hand sanitizer as a reference, firstly taking a beaker of 200m L and a certain amount of weighed purified water, pouring the beaker into the beaker, sequentially adding 10g of sodium dodecyl sulfate, 4.5g of cocamidopropyl betaine and 4g of alkyl glucoside 1214 in the beaker, heating the beaker to 60 ℃ on a stirrer, stirring to completely dissolve the raw materials, then respectively adding 1.5g of glycerol, 0.8g of ethylene glycol monostearate, 0.4g of tetrasodium ethylenediaminetetraacetate, 0.1g of chitosan and 0.01mg of nano silver particles with the diameter of 30nm, continuously stirring until the raw materials are completely dissolved, then cooling to room temperature, then adding the purified water to 100g, adding 1.5g of polyvinylpyrrolidone PVP and 0.5g of citric acid to adjust the viscosity and the pH value, ultrasonically dissolving and removing bubbles, and aging for 3 hours to obtain the colorless and transparent antibacterial hand sanitizer.
The formulation of the antiseptic hand sanitizer containing nano silver in example 1 and the formulation of the hand sanitizer without nano silver in the comparative example are shown in table 1 below.
Table 1:
the hand sanitizer obtained in example 1 and the hand sanitizer obtained in the comparative example are colorless and transparent products with viscoelasticity, the viscosity is 4500mPa & S, and the pH value is 6; the hand washing solutions of example 1 and the comparative example were respectively subjected to antibacterial performance tests, and the results are shown in table 2 below.
Table 2:
as can be seen from Table 2, the antibacterial liquid soap containing nano-silver has an obvious antibacterial effect compared with the liquid soap without nano-silver, can basically kill most bacteria and fungi in a short time, and can more effectively prevent the spread of diseases and prevent infection.
While the foregoing is directed to the preferred embodiment of the present invention, it will be understood by those skilled in the art that various changes and modifications may be made without departing from the spirit and scope of the invention.
Claims (10)
1. An antibacterial and disinfectant hand sanitizer containing nano-silver is characterized by being prepared from the following components in percentage by mass: 0.0005 to 0.05 percent of nano-silver antibacterial disinfectant, 10 to 25 percent of surfactant, 1 to 3 percent of moisturizing factor, 1 to 4 percent of thickening agent, 0.5 to 1 percent of pearling agent, 1 to 2 percent of pH regulator, 0.3 to 0.5 percent of chelating agent, 0.05 to 0.2 percent of preservative and 64.25 to 86.1495 percent of solvent.
2. The antiseptic and disinfectant hand sanitizer containing nano silver as claimed in claim 1, wherein the nano silver particles of the antiseptic and disinfectant agent have a particle size of 10-80 nm.
3. The antibacterial and disinfectant hand sanitizer containing nano-silver as claimed in claim 1 or 2, wherein said surfactant is one or more of sodium lauryl sulfate, α -sulfo fatty acid ester, sodium fatty alcohol polyoxyethylene ether sulfate, cocamidopropyl betaine, lecithin, alkyl glucoside 1214, and coconut oil fatty acid diethanolamide.
4. The antiseptic hand sanitizer containing nano silver as claimed in claim 1 or 2, wherein the humectant is one or more of glycerin, propylene glycol, polyethylene glycol, sodium hyaluronate, and ceramide.
5. The antiseptic hand sanitizer containing nano silver as claimed in claim 1 or 2, wherein the thickener is one or more of polyvinylpyrrolidone, polyvinyl alcohol, polyacrylic acid, sodium chloride, ammonium chloride, potassium chloride.
6. The antibacterial and disinfectant hand sanitizer containing nano-silver as claimed in claim 1 or 2, wherein the pearlizing agent is one of shell powder, mica powder, ethylene glycol monostearate, and ethylene glycol distearate.
7. The antiseptic hand sanitizer containing nano silver as claimed in claim 1 or 2, wherein the pH regulator is one of citric acid, sodium citrate, lactic acid.
8. The antiseptic hand sanitizer containing nano silver as claimed in claim 1 or 2, wherein the chelating agent is one of disodium ethylenediaminetetraacetate, tetrasodium ethylenediaminetetraacetate, and sodium citrate.
9. The antiseptic and disinfectant hand sanitizer containing nano silver as claimed in claim 1 or 2, wherein said antiseptic is chitosan and said solvent is pure water.
10. A method for preparing the antibacterial and disinfectant hand sanitizer containing nano-silver as claimed in any one of claims 1 to 9, which is characterized by comprising the following steps:
a1. weighing the components according to the proportion;
a2. pouring a part of solvent into a container, adding the surfactant into the container, and heating while stirring until the surfactant is completely dissolved;
a3. adding the humectant, the pearling agent, the chelating agent, the preservative and the nano-silver antibacterial disinfectant into a container, heating and stirring the mixture until the mixture is uniformly dispersed, pouring the residual pure water into the container, and cooling the container to room temperature;
a4. respectively adding a pH regulator and a thickening agent into a container, and adjusting the pH value and the viscosity;
a5. dissolving the mixed liquid in the dissolver by using ultrasonic, removing bubbles, and aging to prepare the antibacterial and disinfectant hand sanitizer containing nano silver.
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Application publication date: 20200724 |