CN111671709A - Tea tree essential oil and ethanol double-disinfection and washing-free hand sanitizer and preparation method thereof - Google Patents
Tea tree essential oil and ethanol double-disinfection and washing-free hand sanitizer and preparation method thereof Download PDFInfo
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- CN111671709A CN111671709A CN202010751484.9A CN202010751484A CN111671709A CN 111671709 A CN111671709 A CN 111671709A CN 202010751484 A CN202010751484 A CN 202010751484A CN 111671709 A CN111671709 A CN 111671709A
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- hand sanitizer
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title claims abstract description 96
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- 235000015459 Lycium barbarum Nutrition 0.000 title claims abstract description 42
- 238000004659 sterilization and disinfection Methods 0.000 title claims abstract description 28
- 239000000341 volatile oil Substances 0.000 title claims abstract description 16
- 238000002360 preparation method Methods 0.000 title abstract description 9
- 241000366182 Melaleuca alternifolia Species 0.000 title 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 48
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- 239000000284 extract Substances 0.000 claims abstract description 34
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- CXVGEDCSTKKODG-UHFFFAOYSA-N sulisobenzone Chemical compound C1=C(S(O)(=O)=O)C(OC)=CC(O)=C1C(=O)C1=CC=CC=C1 CXVGEDCSTKKODG-UHFFFAOYSA-N 0.000 claims abstract 2
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- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 10
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- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- WEEGYLXZBRQIMU-UHFFFAOYSA-N Eucalyptol Chemical compound C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 description 2
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- 239000002585 base Substances 0.000 description 2
- 229960000686 benzalkonium chloride Drugs 0.000 description 2
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 2
- 229960005233 cineole Drugs 0.000 description 2
- RWGFKTVRMDUZSP-UHFFFAOYSA-N cumene Chemical compound CC(C)C1=CC=CC=C1 RWGFKTVRMDUZSP-UHFFFAOYSA-N 0.000 description 2
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- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- RFIMISVNSAUMBU-UHFFFAOYSA-N 2-(hydroxymethyl)-2-(prop-2-enoxymethyl)propane-1,3-diol Chemical compound OCC(CO)(CO)COCC=C RFIMISVNSAUMBU-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
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- 235000009840 Crataegus x incaedua Nutrition 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
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- 244000011376 Leptospermum laevigatum Species 0.000 description 1
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- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
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- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
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- 235000006468 Thea sinensis Nutrition 0.000 description 1
- JNGWKQJZIUZUPR-UHFFFAOYSA-N [3-(dodecanoylamino)propyl](hydroxy)dimethylammonium Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)[O-] JNGWKQJZIUZUPR-UHFFFAOYSA-N 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 235000014104 aloe vera supplement Nutrition 0.000 description 1
- PYKYMHQGRFAEBM-UHFFFAOYSA-N anthraquinone Natural products CCC(=O)c1c(O)c2C(=O)C3C(C=CC=C3O)C(=O)c2cc1CC(=O)OC PYKYMHQGRFAEBM-UHFFFAOYSA-N 0.000 description 1
- 150000004056 anthraquinones Chemical class 0.000 description 1
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- 229910052791 calcium Inorganic materials 0.000 description 1
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- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 1
- 238000005202 decontamination Methods 0.000 description 1
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- 229940026210 lauramidopropylamine oxide Drugs 0.000 description 1
- 229940069445 licorice extract Drugs 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
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- 229910052749 magnesium Inorganic materials 0.000 description 1
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- BHAAPTBBJKJZER-UHFFFAOYSA-N p-anisidine Chemical compound COC1=CC=C(N)C=C1 BHAAPTBBJKJZER-UHFFFAOYSA-N 0.000 description 1
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- 150000003739 xylenols Chemical class 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/35—Ketones, e.g. benzophenone
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- A—HUMAN NECESSITIES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
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- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
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- A—HUMAN NECESSITIES
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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- A—HUMAN NECESSITIES
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
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- General Health & Medical Sciences (AREA)
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- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Dispersion Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to a tea tree essential oil and ethanol double-disinfection and no-wash hand sanitizer and a preparation method thereof. The no-clean hand sanitizer contains ethanol, and also contains tea tree extract and aloe extract; the content of the ethanol is 60-75% by mass ratio. Further, the oil-in-water emulsion also contains glycerol, isopropyl myristate, benzophenone-4, a dissolving promoter and a thickening agent. The invention also provides a preparation method of the no-clean hand sanitizer. The invention contains various antibacterial components, takes ethanol as a main bactericide and takes tea tree extract as an auxiliary, and has broad-spectrum antibiotic sterilization and disinfection effects. The aloe fresh leaf extract also contains the aloe fresh leaf extract which has the functions of moisturizing and sun screening, and has the plant skin care function while long-acting sterilization.
Description
Technical Field
The invention relates to daily chemical medical sterilization hand sanitizer, in particular to tea tree essential oil and ethanol double-sterilization no-wash hand sanitizer and a preparation method thereof.
Background
Traditional hand sanitizer and soap are easy to be infected with bacteria brought by other links during hand washing in the using process, bring secondary pollution, and can be carried out only by water at any time and any place. The non-washing hand sanitizer can avoid the problems as a substitute of the traditional hand washing product, can kill other viruses such as coronavirus with the concentration of more than 75 percent, can wash hands at any time and any place in an epidemic situation, and plays a very important role in blocking infection. Meanwhile, compared with perfumed soaps, the formula of the hand sanitizer is relatively mild.
The no-clean liquid soap as a novel daily chemical product is not limited by water sources, has the advantages of wider application, convenient carrying and use when traveling, and the like, but the no-clean liquid soap in the current market brand uses more pure chemical reagents for sterilization, such as ethanol, has greater irritation to the skin of hands, causes side effects such as skin allergy, and the like; in addition, some chemical substances are not easy to degrade, for example, the current chlorine-alkali xylenol disinfectant has corrosiveness and irritation to tissues, steam is toxic to people and low in efficiency, and a large amount of the disinfectant causes phenol pollution to the environment, so that the disinfectant is replaced by other low-toxicity and high-efficiency phenol derivatives.
Chinese patent document CN104414909A (201310378336.7) discloses a no-clean hand sanitizer containing chitosan extract, which is a no-clean hand sanitizer prepared by adding natural plant components such as kazalin, hawthorn seed extract and pomegranate seed extract with antibacterial effect into chitosan, wherein chitosan is a main antibacterial component, and the chitosan can be dissolved into gel which is easy to absorb under the slightly acidic condition, and the natural plant components are added to the chitosan, and the natural plant components are prepared by a special process. Most of the components in the invention are extracted from pure plants, and the decontamination and sterilization capabilities are poor.
Chinese patent document CN105342934A (201510917866.3) discloses a tea tree oil no-clean hand sanitizer, which consists of the following components in percentage by weight: 0.1-2% of benzalkonium chloride, 0.5-3% of coconut diethanolamide, 0.5-3% of lauramidopropyl amine oxide, 5-10% of glycerol, 1-5% of olive oil, 3-10% of vaseline, 1-5% of vitamin E acetate, 1-5% of chitosan, 5-15% of a licorice extract, 1-5% of tea tree oil and the balance of deionized water. The invention takes benzalkonium chloride as a main bactericide, and the bactericidal property and the resistance to partial viruses are not ideal.
With the recent global coronavirus epidemic situation, the requirement for killing viruses of the no-clean hand sanitizer is urgent, and experts point out that alcohol with the concentration of more than 75% can kill the coronaviruses, but when the no-clean hand sanitizer is prepared, if the using amount of the alcohol is large, the no-clean hand sanitizer has high skin irritation, and if the using amount is small, the sterilization and disinfection effects are not ideal. The invention is therefore proposed.
Disclosure of Invention
Aiming at the technical problems, the invention provides a tea tree essential oil and ethanol double-disinfection and no-wash hand sanitizer and a preparation method thereof.
The technical problem to be solved by the invention is as follows: the sterilization capacity of the existing plant no-clean hand sanitizer is improved, and on the premise of ensuring the sterilization capacity, the pure plant extracted tea tree essential oil is added for assisting sterilization, so that the use amount of a chemical bactericide is reduced, and the existence of staphylococcus aureus, mould, escherichia coli, clostridium and the like on hands is reduced. An ethanol content of 75% v/v is also effective in killing coronaviruses.
Description of terms:
95% ethanol is commercially available at a concentration of 95% by volume.
Carbomer is a polymer formed by copolymerizing acrylic acid serving as a monomer and sucrose acrylate ether or pentaerythritol allyl ether serving as a cross-linking agent. Is a hydrophilic polymer compound and is commercially available.
Tea tree essential oil refers to tea tree extract and is available on the market;
the technical scheme of the invention is as follows:
a hand sanitizer containing tea tree essential oil and ethanol for killing and washing away contains ethanol, and is characterized by also containing tea tree extract and aloe extract; the content of the ethanol is 60-75% by mass ratio.
Preferably, the plant bacteriostatic no-clean hand sanitizer contains 70-75% of ethanol; further preferably 72-73%; are all in mass percent.
Preferably, in the plant bacteriostatic no-clean hand sanitizer, the content of the tea tree extract is 0.1-0.5%, and the content of the aloe extract is 0.5-2%, which are mass percentages. The tea tree extract is used as an auxiliary bactericide, and the aloe extract is adopted to moisturize, prevent sun and repair the skin.
Preferably, the plant bacteriostatic no-clean hand sanitizer also contains 2-5% of glycerol, 0.5-1% of isopropyl myristate, a dissolving promoter and a thickening agent. Are all in mass percent.
Preferably, the cosolvent is 1, 2-propylene glycol; further preferably, the content of the dissolution promoter in the no-clean hand sanitizer is 0.1-0.5 mass percent.
Preferably, the thickener is carbomer-U20, carbomer-470 or carbomer-471. Further preferably, the content of the thickening agent in the no-clean hand sanitizer is 0.01-0.5 mass percent.
Preferably, the plant bacteriostatic no-clean hand sanitizer also contains benzyldione-4. The benzyl diketone-4 has the function of absorbing ultraviolet rays and has the function of preventing sunlight in the no-wash hand sanitizer. Further preferably, the content of benzyldione-4 is 0.1 to 0.5%.
A preferred embodiment of the present invention is as follows:
a plant bacteriostatic no-clean hand sanitizer comprises the following components in percentage by mass: 60-75% of ethanol, 0.0001-0.5% of tea tree extract, 0.05-2% of aloe extract, 2-5% of glycerol, 0.5-1% of isopropyl myristate, 40-0.5% of benzyldione, 0.1-0.5% of dissolution promoter, 0.01-0.5% of thickening agent and the balance of water.
More preferably, the embodiments of the present invention are as follows:
a plant bacteriostatic no-clean hand sanitizer comprises the following components in percentage by mass: 70-75% of ethanol, 0.0003-0.5% of tea tree extract, 0.05-1% of aloe extract, 2-5% of glycerol, 0.7-1% of isopropyl myristate, 40.2-0.5% of benzyldione, 0.1-0.3% of cosolvent, 0.01-0.1% of thickening agent and the balance of water.
A preparation method of a tea tree essential oil and ethanol double-disinfection wash-free hand sanitizer comprises the following steps:
(1) adding thickener into water containing Aloe extract at a certain proportion, standing overnight to make thickener absorb water and swell, adjusting pH to 7-8 to obtain transparent thick thickener colloid;
(2) adding glycerol, isopropyl myristate, benzyl diketone-4, cosolvent and tea tree extract into ethanol according to a proportion, and fully stirring to obtain uniformly dispersed mixed solution;
(3) and (3) adding the thickener colloid in the step (1) into the mixed solution in the step (2), and fully stirring for 1-5h to obtain the no-clean hand sanitizer gel.
Preferably, the pH is adjusted to triethanolamine. The acid-base property of the swelling colloid is adjusted, and the viscosity of the colloid is further adjusted. Preferably, the water is distilled water or deionized water.
The tea tree extract and the aloe extract can be purchased from the market, and can also be prepared according to the prior art. For example:
the tea tree extract (tea tree essential oil) is prepared from tea tree leaves and young shoots by extracting with steam distillation, and has an oil yield of about 1.8%. The main components are p-menthene (terpinene), terpineol (pinene), limonene (limonene), cineol (cineole), terpineol (terpineol) and anisidine (cumene).
Preparation of aloe extract: cleaning fresh aloe leaves, peeling, pulverizing, homogenizing to obtain aloe raw juice, centrifuging to remove plant fiber in the aloe raw juice to obtain aloe raw juice; treating the obtained aloe juice with adsorption resin to remove anthraquinone, removing calcium and magnesium with ion exchange resin, and sterilizing to obtain aloe extractive solution.
The invention has the technical characteristics and beneficial effects that:
the tea tree essential oil and ethanol double-disinfection and sterilization hand sanitizer takes ethanol as a main bactericide, a tea tree extract (tea tree essential oil) as an auxiliary bactericide and an aloe extract as a skin care component, has the functions of sterilization, inflammation diminishing and mite removing, and has the functions of corrosion prevention, fungus resistance and virus resistance, and the pure plant extract bactericide can effectively sterilize and sterilize in a broad spectrum by combining with ethanol, and the using amount of the ethanol is reduced.
The invention discovers that the pure plant tea tree extract has the effect of assisting disinfection and sterilization, and meanwhile, the tea tree extract can stimulate the resistance of a human body and improve the resistance. The tea tree extract as plant essence also has the characteristics of environmental protection and no residue, and does not damage nature. The hand sanitizer formula of the auxiliary disinfectant and bactericide extracted from the pure plants is more extracted from the pure plants, does not cause harm to people, and does not have more chemical reagents remained in nature.
The hand protecting part of the invention is mainly extracted from pure plant aloe, and the aloe is a plant which has the functions of moisturizing, sun-screening and repairing in nature. Preferably, the content of aloe extract is 0.5-2%. The aloe fresh leaf extract is used as a hand protection part, naturally protects and nourishes the skin, and is more environment-friendly and milder to the body.
The ethanol is used as a main bactericide, the ethanol content in the hand sanitizer can reach 75 percent through a specific preparation method, the coronavirus can be effectively killed, and the no-clean hand sanitizer can completely kill mould, fungus, escherichia coli, clostridium and staphylococcus. An ethanol content of 75% v/v is also effective in killing coronaviruses.
Detailed Description
The present invention is further illustrated by, but not limited to, the following examples.
Tea plant extract, aloe vera extract, and other materials in the examples are commercially available. Wherein the tea tree extract is commercially available Australian tea tree essential oil, and the aloe extract is commercially available Aloe barbadensis Miller extract produced from Aloe barbadensis Miller base of Yuanjiang.
The water in the examples is distilled water.
The carbomer colloids used in the examples were prepared as follows:
carbomer-U201 g, aloe extract 5g, and water 994g, mixing aloe extract and water uniformly. Then adding carbomer-U20, standing overnight to make the thickener swell by absorbing water, and adjusting pH to 7-8 to obtain transparent thick carbomer colloid.
Example 1:
adding 0.5g of glycerol, 0.03g of 1, 2-propylene glycol, 0.1g of isopropyl myristate, 0.05g of benzyldione-4 and 0.06mg of tea tree extract into 9.5g of 95% ethanol, fully stirring for dissolving, adding 2.5g of carbomer colloid, and fully stirring for 4 hours to obtain the hand sanitizer with the ethanol content of about 71 mass percent.
Example 2:
adding 0.5g of glycerol, 0.03g of 1, 2-propylene glycol, 0.1g of isopropyl myristate, 0.05g of benzyldione-4 and 0.06mg of tea tree extract into 9g of 95% ethanol, fully stirring for dissolving, adding 3g of carbomer colloid, and fully stirring for 4 hours to obtain the hand sanitizer with the ethanol content of about 67% by mass.
Example 3:
adding 0.3g of glycerol, 0.03g of 1, 2-propylene glycol, 0.1g of isopropyl myristate, 0.05g of benzyldione-4 and 0.06mg of tea tree extract into 9.5g of 95% ethanol, fully stirring for dissolving, adding 2.5g of carbomer colloid, and fully stirring for 4 hours to obtain the hand sanitizer with the ethanol content of about 72% by mass.
Example 4:
adding 0.5g of glycerol, 0.02g of 1, 2-propylene glycol, 0.1g of isopropyl myristate, 0.05g of benzyldione-4 and 0.06mg of tea tree extract into 9.5g of 95% ethanol, fully stirring for dissolving, adding 2.5g of carbomer colloid, and fully stirring for 4 hours to obtain the hand sanitizer with the ethanol content of about 71 mass percent.
Example 5:
adding 0.5g glycerol, 0.03g 1, 2-propylene glycol, 0.12g isopropyl myristate, 0.05g benzyl dione-4, and 0.06mg tea tree extract into 9.5g 95% ethanol, stirring to dissolve, adding 2.5g carbomer colloid, and stirring for 4 hr. The ethanol content of the obtained hand sanitizer is about 71 mass percent.
Example 6:
adding 0.5g glycerol, 0.03g 1, 2-propylene glycol, 0.1g isopropyl myristate, 0.06g benzyl dione-4, and 0.06mg tea tree extract into 9.5g 95% ethanol, stirring to dissolve, adding 2.5g carbomer gel, and stirring for 4 hr. The ethanol content of the obtained hand sanitizer is about 72 mass percent.
Bacteriostatic experiments:
performing shake culture on 6 bacteria in a culture solution at 37 ℃ for 24h, diluting the bacteria solution to a bacteria concentration of 108CFU/mL, and uniformly coating the bacteria on an agar culture dish to prepare 6 culture dishes for experiments; a piece of round paper soaked with 1mL of the wash-free hand sanitizer obtained in example 6 of the present invention was placed in the above-mentioned petri dish as an experimental group. These dishes were then placed in an incubator at 37 ℃ for 24 h. The bacterial colony cultured by the culture medium before the washing-free liquid soap is used is infinite, various bacterial colonies pass through detection, and only the bacterial colony of the detected washing-free liquid soap product and the detected bacterial colony of a sample are all 0. The test standard implements GB 27951-:
experimental example 1 bacteriostatic experiment:
respectively carrying out shake culture on escherichia coli, staphylococcus aureus, pseudomonas aeruginosa and hemolytic streptococcus meeting the requirements in the table 1 in a culture solution at 37 ℃ for 24 hours, then diluting the culture solution until the bacterial concentration is 108CFU/mL, and uniformly smearing bacteria on an agar culture dish to prepare 4 culture dishes for experiments; a round paper piece soaked with 1mL of the wash-free hand lotion obtained in example 1 of the present invention was placed in the above-mentioned petri dish as an experimental group. These dishes were then placed in an incubator at 37 ℃ for 24 h. The bacterial colony cultured by the culture medium before the washing-free liquid soap is used is infinite, various bacterial colonies pass through detection, and only the bacterial colony of the detected washing-free liquid soap product and the detected bacterial colony of a sample are all 0. The detection standard meets the GB27950-2011 hand disinfectant sanitation requirement, and the sterilization result is as follows:
the product microbiological indicator should comply with the regulations of table 1.
TABLE 1
| Item | Index (I) |
| Total bacterial colony count (cfu/g or cfu/mL) | ≤200 |
| Total fungal colony count (cfu/g or cfu/mL) | ≤100 |
| Coliform group bacteria | Cannot be detected |
| Staphylococcus aureus | Cannot be detected |
| Pseudomonas aeruginosa | Cannot be detected |
| Hemolytic streptococcus | Cannot be detected |
According to the instruction of the product, the microorganism killing effect meets the specification of the table 2.
TABLE 2
The leave-in hand cleaners of examples 1-5 were tested for bacteriology according to the above procedure, and all the plates containing the hand cleaner had 0 colony count. The results are the same as in Table 1.
Hand disinfection field experiment:
subjects were randomly selected 40 according to Disinfection Specification 2002. Before disinfection, the testee rubs with both hands to make the natural bacteria distribution of both hands nearly equal, and after the aseptic cotton swab is soaked in diluent and is firstly sampled with one hand, the sampling end of the cotton swab is cut into a neutralization reagent to be used as a positive control group sample. The other hand was sterilized with the sample of example 5 of the present invention for 1min, and the natural bacteria remaining on the hand after sterilization were sampled once in the same manner as the positive control group and used as the test group sample. The unused neutralizer, cotton swab and diluent in the same batch are respectively used as negative control group samples. Respectively taking 1mL of samples of the test group, the positive control group and the negative control group, inoculating the samples into the plates by an agar pouring method, inoculating 2 plates into each sample, placing the samples into a 37 ℃ incubator for culturing for 48 hours, and observing the final result. The average killing logarithm value of the natural bacteria on the hands of 40 persons is more than or equal to 1.00, and the sterilization is qualified. The bactericidal effect is shown in table 3.
Table 3: sterilizing effect after hand sanitizer spraying
Claims (10)
1. A hand sanitizer containing tea tree essential oil and ethanol for killing and washing away contains ethanol, and is characterized by also containing tea tree extract and aloe extract; the content of the ethanol is 60-75% by mass ratio.
2. The leave-in hand sanitizer according to claim 1, wherein said ethanol content is from 70 to 75% by mass; preferably 72-73% by mass.
3. The non-washing hand sanitizer according to claim 1, wherein the plant bacteriostatic non-washing hand sanitizer contains 0.00011 to 0.5 percent of tea tree extract and 0.05 to 2 percent of aloe extract, which are all in percentage by mass.
4. The no-clean hand sanitizer according to claim 1, wherein the plant bacteriostatic no-clean hand sanitizer further comprises 2 to 5 mass percent of glycerol, 0.5 to 1 mass percent of isopropyl myristate, a dissolution promoter and a thickening agent.
5. The leave-in hand sanitizer according to claim 1, wherein said dissolution enhancer is 1, 2-propylene glycol; preferably, the content of the dissolution accelerator is 0.1-0.5% by mass; the thickening agent is carbomer-U20, carbomer-470 or carbomer-471; preferably, the content of the thickener is 0.01 to 0.5 mass%.
6. The wash-free hand sanitizer according to claim 1, further preferably, the wash-free hand sanitizer further comprises benzophenone-4; the content of tolyldione-4 is preferably 0.1 to 0.5% by mass.
7. The no-clean hand sanitizer according to claim 1, which consists of, by mass: 60-75% of ethanol, 0.0001-0.5% of tea tree extract, 0.05-2% of aloe extract, 2-5% of glycerol, 0.5-1% of isopropyl myristate, 40-0.5% of benzyldione, 0.1-0.5% of dissolution promoter, 0.01-0.5% of thickening agent and the balance of water.
8. The no-clean hand sanitizer according to claim 1, which consists of, by mass: 70-75% of ethanol, 0.0003-0.5% of tea tree extract, 0.05-1% of aloe extract, 2-5% of glycerol, 0.8-1% of isopropyl myristate, 40.2-0.5% of benzyldione, 0.1-0.3% of cosolvent, 0.02-0.08% of thickening agent and the balance of water.
9. A process for preparing a tea tree essential oil and ethanol double disinfection and no-wash hand sanitizer according to any one of claims 1 to 8, which comprises:
(1) adding thickener into water containing Aloe extract at a certain proportion, standing overnight to make thickener absorb water and swell, adjusting pH to 7-8 to obtain transparent thick thickener colloid;
(2) adding glycerol, isopropyl myristate, benzyl diketone-4, cosolvent and tea tree extract into ethanol according to a proportion, and fully stirring to obtain uniformly dispersed mixed solution;
(3) and (3) adding the thickener colloid in the step (1) into the mixed solution in the step (2), and fully stirring for 1-5h to obtain the no-clean hand sanitizer gel.
10. The method for preparing a tea tree essential oil and ethanol double-disinfection no-wash hand sanitizer according to claim 9, wherein the pH is adjusted to triethanolamine; preferably, the water is distilled water or deionized water.
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| CN111944617A (en) * | 2020-08-19 | 2020-11-17 | 河南昇阳生物科技有限公司 | Composite water-free hand sanitizer containing amino acid |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1596877A (en) * | 2003-09-16 | 2005-03-23 | 上海拜耳科生物科技有限公司 | Antiseptic hand cleaning liquid with out water cleaning and its preparation method |
| KR20120063036A (en) * | 2010-12-07 | 2012-06-15 | 전라남도 | Method for manufacturing handwash and handwash composition thereof containing natural oriental plant extracts |
| CN106309273A (en) * | 2016-08-25 | 2017-01-11 | 攀柔莎（江苏）生物科技股份有限公司 | Skin care leave-in liquid soap |
| CN107714549A (en) * | 2017-11-10 | 2018-02-23 | 天津中澳嘉喜诺生物科技有限公司 | A kind of disposable hand cleanser of tea tree hydrosol and preparation method thereof |
-
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1596877A (en) * | 2003-09-16 | 2005-03-23 | 上海拜耳科生物科技有限公司 | Antiseptic hand cleaning liquid with out water cleaning and its preparation method |
| KR20120063036A (en) * | 2010-12-07 | 2012-06-15 | 전라남도 | Method for manufacturing handwash and handwash composition thereof containing natural oriental plant extracts |
| CN106309273A (en) * | 2016-08-25 | 2017-01-11 | 攀柔莎（江苏）生物科技股份有限公司 | Skin care leave-in liquid soap |
| CN107714549A (en) * | 2017-11-10 | 2018-02-23 | 天津中澳嘉喜诺生物科技有限公司 | A kind of disposable hand cleanser of tea tree hydrosol and preparation method thereof |
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