CN110859772A - Composition with seven whitening effects and preparation method and application thereof - Google Patents
Composition with seven whitening effects and preparation method and application thereof Download PDFInfo
- Publication number
- CN110859772A CN110859772A CN201911088331.4A CN201911088331A CN110859772A CN 110859772 A CN110859772 A CN 110859772A CN 201911088331 A CN201911088331 A CN 201911088331A CN 110859772 A CN110859772 A CN 110859772A
- Authority
- CN
- China
- Prior art keywords
- extract
- parts
- melanin
- inhibitor
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9755—Gymnosperms [Coniferophyta]
- A61K8/9767—Pinaceae [Pine family], e.g. pine or cedar
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The invention belongs to the technical field of cosmetics, and particularly relates to a composition with seven whitening effects, and a preparation method and application thereof. The composition with seven whitening effects provided by the invention comprises the following components in parts by weight: 8-12 parts of antioxidant, 2-5 parts of melanin synthesis inhibitor, 1-3 parts of enzyme inhibitor, 1-2 parts of melanin polymer inhibitor, 4-7 parts of melanin reducer, 2-4 parts of melanin transfer inhibitor and 3-5 parts of metabolism promoter. The composition with seven whitening effects provided by the invention follows the skin physiology knowledge and melanin anabolism process route, solves the whitening problem through a reasonable and scientific skin physiological structure, and has a remarkable whitening effect.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to a composition with seven whitening effects, and a preparation method and application thereof.
Background
Melanocytes are located in the basal layer of the skin and are a bridge for the association of glandular cells with dendrites, the dendrite transport pathway, and keratinocytes. Melanin acts like a cap to protect the nucleus of keratinocytes, provides UV protection to the keratinocyte genetic material, forms pigmentation in the epidermis, and also provides protection for dermal proteins, collagen, elastin. In the epidermis, there are about 1 melanocyte per 36 keratin cells, which form a melanin unit.
The keratinocyte is stimulated by external UV and ROS to release cytokines such as inflammatory factor, endothelin-1, melanocortin α -MSH and the like, and the cytokines are combined with a receptor on melanin to activate the synthesis of tyrosinase and promote the generation of the melanin, and the melanin is transferred to the keratinocyte after being matured and is continuously peeled off from the skin epidermis through the metabolism of the epidermal keratinocyte.
Chinese patent CN104840380B discloses a natural substance composition and application thereof in whitening cosmetics. The natural substance composition is composed of the acerola extract essence, the salvia miltiorrhiza leaf extract essence and the hairyvein agrimonia herb and bud extract according to the proportion of 3-5:2-6:1-5, and the composition has the function of obviously inhibiting the activity of tyrosinase, thereby inhibiting the generation of melanin. However, the composition is only whitened in view of inhibiting tyrosinase activity.
At present, the whitening products on the market only whiten the skin in the aspects of tyrosinase activity inhibition, inflammation resistance, moisture retention, oxidation resistance and the like, and the whitening problem is not solved through a reasonable and scientific skin physiological structure.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide a composition with seven whitening effects, and a preparation method and application thereof. The composition with seven whitening effects provided by the invention follows the skin physiology knowledge and melanin anabolism process route, solves the whitening problem through a reasonable and scientific skin physiological structure, and has a remarkable whitening effect.
The technical scheme of the invention is as follows:
a composition with seven whitening effects comprises the following components in parts by weight:
8-12 parts of antioxidant, 2-5 parts of melanin synthesis inhibitor, 1-3 parts of enzyme inhibitor, 1-2 parts of melanin polymer inhibitor, 4-7 parts of melanin reducer, 2-4 parts of melanin transfer inhibitor and 3-5 parts of metabolism promoter.
Further, the composition with seven whitening effects comprises the following components in parts by weight:
10 parts of antioxidant, 4 parts of melanin synthesis inhibitor, 2 parts of enzyme inhibitor, 1 part of melanin polymer inhibitor, 6 parts of melanin reducer, 2 parts of melanin transfer inhibitor and 3 parts of metabolism promoter.
Further, the antioxidant is one or more of superoxide dismutase, hesperidin, astaxanthin, 2-O-ethyl ascorbic acid, sodium ascorbyl phosphate, lipoic acid, licorice extract, rhodiola rosea extract, grape seed extract, peony root extract, dimethyl methoxy chromanol, maritime pine bark/bud extract, collard extract and acerola extract.
Preferably, the antioxidant comprises the following components in parts by weight:
5-8 parts of astaxanthin, 2-5 parts of sodium ascorbyl phosphate, 3-6 parts of licorice extract and 1-2 parts of dimethyl methoxy chromanol.
More preferably, the antioxidant comprises the following components in parts by weight:
7 parts of astaxanthin, 3 parts of sodium ascorbyl phosphate, 5 parts of licorice extract and 1 part of dimethyl methoxy chromanol.
Further, the melanin synthesis inhibitor is one or more of ascorbyl tetraisopalmitate, phloretin, chamomile extract, saururus chinensis extract, camellia extract, narcissus extract, oldenlandia diffusa extract, and cnidium officinale root water.
Preferably, the melanin synthesis inhibitor is prepared from phloretin, saururus chinensis extract and daffodil extract in a mass ratio of 2-4: 5-8: 10-15.
More preferably, the melanin synthesis inhibitor is prepared from phloretin, saururus chinensis extract and daffodil extract in a mass ratio of 3: 7: 13 of the composition.
Further, the enzyme inhibitor is one or more of methylgentisate, glucosamine, tunicamycin, licoflavone, birch extract, arbutin, strawberry polyphenol, ligusticum chuanxiong extract, paper mulberry extract, emblic extract, gallic acid, cherry extract, glabridin, dianella ensifolia extract, 4-butylresorcinol, 4-hexylresorcinol, diglucosylgallic acid, scutellaria root extract, mulberry root extract, palmitoyl proline sodium, nymphaea alba extract, carex glauca extract, ursolic acid, and kojic acid dipalmitate.
Preferably, the enzyme inhibitor comprises the following components in parts by weight:
1-2 parts of licorice flavone, 4-7 parts of strawberry polyphenol, 3-5 parts of oriental cherry extract, 2-3 parts of diglucosyl gallic acid and 1-2 parts of sodium palmitoyl prolinate.
More preferably, the enzyme inhibitor comprises the following components in parts by weight:
2 parts of licoflavone, 5 parts of strawberry polyphenol, 4 parts of cherry blossom extract, 2 parts of diglucosylgallic acid and 1 part of sodium palmitoyl prolinate.
Further, the melanin polymerization inhibitor is one or more of 3-O-ethyl ascorbic acid, kojic acid, green tea extract, saxifrage extract, and Scutellaria baicalensis extract.
Preferably, the melanin polymerization inhibitor is prepared from kojic acid, saxifrage extract and scutellaria baicalensis extract in a mass ratio of 5-8: 2-3: 1-2.
More preferably, the melanin polymerization inhibitor is prepared from kojic acid, saxifrage extract and scutellaria baicalensis extract in a mass ratio of 6: 2: 1.
Further, the melanin reducer is one or more of ascorbic acid, vitamin E, procyanidine, ellagic acid, zinc sulfate, ferulic acid, curcumin, citron extract, tranexamic acid, and Uygur false indigo extract.
Preferably, the melanin-reducing agent is prepared from vitamin E, curcumin and citron extract according to a mass ratio of 8-10: 4-6: 1-3.
More preferably, the melanin-reducing agent is prepared from vitamin E, curcumin and citron extract according to a mass ratio of 9: 5: 2.
Further, the melanin transfer inhibitor is one or more of vitamin A acid, linoleic acid, thyme extract, soybean extract, bergamot fruit extract, magnesium ascorbyl phosphate, ascorbyl palmitate, nicotinamide, Magnolia sieboldii extract, Prunus cerasifera extract, resveratrol, and plankton extract.
Preferably, the melanin transfer inhibitor is prepared by mixing linoleic acid, bergamot fruit extract and magnolia sieboldii extract according to a mass ratio of 5-8: 3-5: 2-4.
More preferably, the melanin transfer inhibitor is prepared from linoleic acid, bergamot fruit extract and magnolia sieboldii extract in a mass ratio of 8: 3: 3, and (3).
Further, the metabolism promoter is one or more of lactic acid, keratinase, polyvinyl alcohol, allantoin, 4-methoxy potassium salicylate, salicylic acid, azelaic acid, oxothiazolidine carboxylic acid, glycolic acid, gluconolactone, lactobionic acid, white willow bark extract, and semen Nelumbinis fermentation liquid.
Preferably, the metabolism promoter is prepared from allantoin, glycolic acid and white willow bark extract according to a mass ratio of 1: 2-3: 9-12.
More preferably, the metabolism promoter is prepared from allantoin, glycolic acid and white willow bark extract according to a mass ratio of 1: 2: 10.
The invention also provides a preparation method of the composition with seven whitening effects, which comprises the following steps:
(1) uniformly mixing an antioxidant, a melanin synthesis inhibitor, an enzyme inhibitor, a melanin polymer inhibitor, a melanin reducing agent, a melanin transfer inhibitor and a metabolism promoter to obtain a mixture;
(2) and (2) adding a carboxymethyl chitosan aqueous solution with the mass concentration of 5% into the mixture obtained in the step (1), wherein the amount of the carboxymethyl chitosan aqueous solution is 10-15 times of that of the mixture obtained in the step (1), homogenizing at the homogenizing speed of 1500-2500r/min for 8-15min, and spray drying to obtain the carboxymethyl chitosan/carboxymethyl chitosan.
The invention also aims to provide application of the composition with seven whitening effects in preparing whitening cosmetics.
The whitening cream comprises the following components in percentage by mass: 5-8% of the composition with seven whitening effects, 2-5% of cetyl stearate alcohol, 5-7% of squalane, 3-5% of shea butter, 5-9% of glycerol, 0.1-0.3% of hydroxyethyl cellulose, 0.1-0.1% of tween 600.05, 0.1-0.3% of triethanolamine, 0.05-0.1% of phenoxyethanol, 0.05-0.1% of essence and 65.1-79.65% of deionized water.
Further, the whitening cream comprises the following components in percentage by mass: 6% of the composition with seven whitening effects, 4% of cetyl stearate alcohol, 6% of squalane, 4% of shea butter, 7% of glycerol, 0.1% of hydroxyethyl cellulose, 600.05% of tween, 0.1% of triethanolamine, 0.06% of phenoxyethanol, 0.05% of essence and 72.64% of deionized water.
The preparation method of the whitening cream comprises the following steps:
s1, putting cetyl stearyl alcohol, squalane and shea butter into an oil phase pot, heating to 70-80 ℃, stirring at the speed of 300-;
s2, putting deionized water into a water phase pot, adding glycerol, hydroxyethyl cellulose and Tween 60, heating to 70-80 ℃, stirring at the speed of 1000-2000r/min for 5-10min to obtain a water phase;
s3, adding the oil phase obtained in the step S1 into the water phase obtained in the step S2, and homogenizing at the homogenizing speed of 2500-3500r/min for 8-13min to obtain a homogeneous liquid;
s4 cooling the homogenized solution obtained in step S3 to 45 ℃, adding the composition with seven whitening effects, homogenizing at 2500-.
In the invention, the antioxidant can resist ROS generated by exogenous stimulation (such as UV irradiation, insufficient sleep, environmental pollution and the like). The melanin synthesis inhibitor prevents the production and transformation of melanin by inhibiting the growth and differentiation of melanocytes. The enzyme inhibitor can significantly reduce melanin production by inhibiting the activity of enzymes essential for melanin production, including tyrosinase, dopachrome tautomerase, and DHICA-oxidase, which are enzymes essential for melanin synthesis. The melanin polymerization inhibitor can inhibit melanin from polymerizing into large melanin polymer, which can make skin color uneven, and is the main reason for forming large visible color spots, and can inhibit their aggregation, and can make skin color uniform. The melanin reducer can reduce the formed melanin, and the formed melanin in the facial epidermal cells or the melanocytes is reduced by the reductive active substances, so that the skin can reappear the luster. The melanin transfer inhibitor can inhibit the transfer of melanin from melanocyte to keratinocyte, and prevent skin from blackening. The metabolism promoter can promote rapid exfoliation of horny layer cells, stimulate acceleration of metabolism of epidermal cells, and facilitate rapid metabolism of horny cells containing melanin.
The composition with seven whitening effects prepared by the method of the invention integrates all the components, ensures the uniformity of the effective components and is beneficial to the uniformity and stability of the functions of the prepared cosmetics.
Compared with the prior art, the invention has the following advantages:
(1) the composition with seven whitening effects provided by the invention solves the whitening problem through reasonable and scientific skin physiological structure.
(2) The composition with seven whitening effects comprises an antioxidant, a melanin synthesis inhibitor, an enzyme inhibitor, a melanin polymer inhibitor, a melanin reducing agent, a melanin transfer inhibitor and a metabolism promoter, and all the components play a synergistic role, so that the composition has a remarkable skin whitening effect.
Detailed Description
The present invention is further described in the following description of the specific embodiments, which is not intended to limit the invention, but various modifications and improvements can be made by those skilled in the art according to the basic idea of the invention, within the scope of the invention, as long as they do not depart from the basic idea of the invention.
The various starting materials used in the present invention can be obtained commercially without specific mention. As in the specific examples, the licorice extract is available from sienna baiste biotechnology limited under the trade name: BH 0432; saururus chinensis extract is available from sienna jin chemist limited, cat #: JH 01; the narcissus extract can be purchased from sanyuan longsheng biotechnology limited responsibility, the cargo number: LXSXH; licoflavone is available from sierra enchance biotechnology limited, cat #: RY 0817; strawberry polyphenols are available from Shaanxi Cuiya Yajia Biotech limited, cat #: CYJ-GSFXL 0516; cherry flower extracts are available from shanxi forest fr natural products limited, cat #: SF 201606; saxifrage extract is available from sienga and biotechnology limited, cat #: JH-497; the scutellaria baicalensis extract can be purchased from seian first crop biotechnology limited, cat #: SH-01-05; citron extracts are available from sienna herbert biotechnology limited under the trade designation: BH 0391; bergamot fruit extract is available from sienna green as spring biotechnology limited, cat #: lrq 41245; magnolia sieboldii extract is available from sienna biotechnology limited, cat #: ZL 0731; white willow bark extract is available from Shanxi Chuanchi Biotech limited under the cat #: cj 19032803.
Example 1A composition having seven whitening effects
The composition with seven whitening effects comprises the following components in parts by weight:
8 parts of antioxidant, 2 parts of melanin synthesis inhibitor, 1 part of enzyme inhibitor, 1 part of melanin polymer inhibitor, 4 parts of melanin reducer, 2 parts of melanin transfer inhibitor and 3 parts of metabolism promoter.
The antioxidant comprises the following components in parts by weight: 5 parts of astaxanthin, 2 parts of sodium ascorbyl phosphate, 3 parts of licorice extract and 1 part of dimethyl methoxy chromanol; the melanin synthesis inhibitor is prepared from phloretin, a saururus chinensis extract and a daffodil extract according to a mass ratio of 2: 8: 15; the enzyme inhibitor comprises the following components in parts by weight: 1 part of licoflavone, 4 parts of strawberry polyphenol, 3 parts of cherry blossom extract, 2 parts of diglucosylgallic acid and 1 part of sodium palmitoyl prolinate; the melanin polymerization inhibitor is prepared from kojic acid, saxifrage extract and scutellaria baicalensis extract according to a mass ratio of 5: 3: 2, preparing a composition; the melanin reducer is prepared from vitamin E, curcumin and citron extracts in a mass ratio of 8: 6: 3, preparing a composition; the melanin transfer inhibitor is prepared from linoleic acid, bergamot fruit extract and magnolia sieboldii extract according to the mass ratio of 5: 5: 4, preparing a composition; the metabolism promoter is prepared from allantoin, glycolic acid and white willow bark extract according to a mass ratio of 1: 3: 12.
The preparation method of the composition with seven whitening effects comprises the following steps:
(1) uniformly mixing an antioxidant, a melanin synthesis inhibitor, an enzyme inhibitor, a melanin polymer inhibitor, a melanin reducing agent, a melanin transfer inhibitor and a metabolism promoter to obtain a mixture;
(2) and (2) adding a carboxymethyl chitosan aqueous solution with the mass concentration of 5% into the mixture obtained in the step (1), wherein the amount of the carboxymethyl chitosan aqueous solution is 10 times of that of the mixture obtained in the step (1), homogenizing at the homogenizing speed of 1500r/min for 8min, and spray-drying to obtain the carboxymethyl chitosan/.
Example 2A composition having seven whitening effects
The composition with seven whitening effects comprises the following components in parts by weight:
12 parts of antioxidant, 5 parts of melanin synthesis inhibitor, 3 parts of enzyme inhibitor, 2 parts of melanin polymer inhibitor, 7 parts of melanin reducer, 4 parts of melanin transfer inhibitor and 5 parts of metabolism promoter.
The antioxidant comprises the following components in parts by weight: 8 parts of astaxanthin, 5 parts of sodium ascorbyl phosphate, 6 parts of licorice extract and 2 parts of dimethyl methoxy chromanol; the melanin synthesis inhibitor is prepared from phloretin, a saururus chinensis extract and a daffodil extract according to a mass ratio of 4: 5: 10; the enzyme inhibitor comprises the following components in parts by weight: 2 parts of licoflavone, 7 parts of strawberry polyphenol, 5 parts of cherry blossom extract, 3 parts of diglucosylgallic acid and 2 parts of sodium palmitoyl prolinate; the melanin polymerization inhibitor is prepared from kojic acid, saxifrage extract and scutellaria baicalensis extract according to a mass ratio of 8: 2: 1, preparing a composition; the melanin reducer is prepared from vitamin E, curcumin and citron extracts in a mass ratio of 10: 4: 1, preparing a composition; the melanin transfer inhibitor is prepared from linoleic acid, bergamot fruit extract and magnolia sieboldii extract according to the mass ratio of 8: 3: 2, preparing a composition; the metabolism promoter is prepared from allantoin, glycolic acid and white willow bark extract according to a mass ratio of 1: 2: 9.
The preparation method of the composition with seven whitening effects comprises the following steps:
(1) uniformly mixing an antioxidant, a melanin synthesis inhibitor, an enzyme inhibitor, a melanin polymer inhibitor, a melanin reducing agent, a melanin transfer inhibitor and a metabolism promoter to obtain a mixture;
(2) and (2) adding a carboxymethyl chitosan aqueous solution with the mass concentration of 5% into the mixture obtained in the step (1), wherein the amount of the carboxymethyl chitosan aqueous solution is 15 times of that of the mixture obtained in the step (1), homogenizing at the homogenizing speed of 2500r/min for 15min, and spray-drying to obtain the carboxymethyl chitosan/.
Example 3A composition having seven whitening effects
The composition with seven whitening effects comprises the following components in parts by weight:
10 parts of antioxidant, 4 parts of melanin synthesis inhibitor, 2 parts of enzyme inhibitor, 1 part of melanin polymer inhibitor, 6 parts of melanin reducer, 2 parts of melanin transfer inhibitor and 3 parts of metabolism promoter.
The antioxidant comprises the following components in parts by weight: 7 parts of astaxanthin, 3 parts of sodium ascorbyl phosphate, 5 parts of licorice extract and 1 part of dimethyl methoxy chromanol; the melanin synthesis inhibitor is prepared from phloretin, a saururus chinensis extract and a daffodil extract according to a mass ratio of 3: 7: 13; the enzyme inhibitor comprises the following components in parts by weight: 2 parts of licoflavone, 5 parts of strawberry polyphenol, 4 parts of cherry blossom extract, 2 parts of diglucosylgallic acid and 1 part of sodium palmitoyl prolinate; the melanin polymerization inhibitor is prepared from kojic acid, saxifrage extract and scutellaria baicalensis extract according to a mass ratio of 6: 2: 1, preparing a composition; the melanin reducer is prepared from vitamin E, curcumin and citron extracts in a mass ratio of 9: 5:2, preparing a composition; the melanin transfer inhibitor is prepared from linoleic acid, bergamot fruit extract and magnolia sieboldii extract according to the mass ratio of 8: 3: 3, preparing a composition; the metabolism promoter is prepared from allantoin, glycolic acid and white willow bark extract according to a mass ratio of 1: 2: 10.
The preparation method of the composition with seven whitening effects comprises the following steps:
(1) uniformly mixing an antioxidant, a melanin synthesis inhibitor, an enzyme inhibitor, a melanin polymer inhibitor, a melanin reducing agent, a melanin transfer inhibitor and a metabolism promoter to obtain a mixture;
(2) adding a carboxymethyl chitosan aqueous solution with the mass concentration of 5% into the mixture obtained in the step (1), wherein the amount of the carboxymethyl chitosan aqueous solution is 12 times of that of the mixture obtained in the step (1), homogenizing at the homogenizing speed of 2200r/min for 13min, and spray-drying to obtain the carboxymethyl chitosan/carboxymethyl.
Example 4 whitening cream
The whitening cream comprises the following components in percentage by mass: composition with seven-fold whitening efficacy prepared in example 1 6%, cetearyl alcohol 4%, squalane 6%, shea butter 4%, glycerin 7%, hydroxyethyl cellulose 0.1%, tween 600.05%, triethanolamine 0.1%, phenoxyethanol 0.06%, perfume 0.05%, deionized water 72.64%.
The preparation method of the whitening cream comprises the following steps:
s1, adding cetyl stearyl alcohol, squalane and shea butter into an oil phase pot, heating to 70 ℃, stirring at the speed of 300r/min for 15min to obtain an oil phase;
s2, adding deionized water into a water phase pot, adding glycerol, hydroxyethyl cellulose and Tween 60, heating to 70 ℃, stirring at the stirring speed of 1000r/min for 5min to obtain a water phase;
s3, adding the oil phase obtained in the step S1 into the water phase obtained in the step S2, and homogenizing at the homogenizing speed of 2500r/min for 8min to obtain a homogenized liquid;
s4 cooling the homogenized solution obtained in step S3 to 45 deg.C, adding the composition with seven-fold whitening effects, homogenizing at 2500r/min for 4min, adding triethanolamine, phenoxyethanol and essence, stirring, and cooling to room temperature.
Example 5 whitening cream
The whitening cream comprises the following components in percentage by mass: composition with seven-fold whitening efficacy prepared in example 2 6%, cetearyl alcohol 4%, squalane 6%, shea butter 4%, glycerin 7%, hydroxyethyl cellulose 0.1%, tween 600.05%, triethanolamine 0.1%, phenoxyethanol 0.06%, perfume 0.05%, deionized water 72.64%.
The preparation method of the whitening cream comprises the following steps:
s1, adding cetyl stearyl alcohol, squalane and shea butter into an oil phase pot, heating to 80 ℃, stirring at the speed of 500r/min for 25min to obtain an oil phase;
s2, adding deionized water into a water phase pot, adding glycerol, hydroxyethyl cellulose and Tween 60, heating to 80 ℃, and stirring at 2000r/min for 10min to obtain a water phase;
s3, adding the oil phase obtained in the step S1 into the water phase obtained in the step S2, and homogenizing at 3500r/min for 13min to obtain a homogenized liquid;
s4, when the temperature of the homogenized liquid obtained in the step S3 is reduced to 45 ℃, adding the composition with seven whitening effects, homogenizing at 3500r/min for 7min, adding triethanolamine, phenoxyethanol and essence, stirring uniformly, and cooling to room temperature to obtain the product.
Example 6 whitening cream
The whitening cream comprises the following components in percentage by mass: composition with seven-fold whitening efficacy prepared in example 3 6%, cetearyl alcohol 4%, squalane 6%, shea butter 4%, glycerin 7%, hydroxyethyl cellulose 0.1%, tween 600.05%, triethanolamine 0.1%, phenoxyethanol 0.06%, perfume 0.05%, deionized water 72.64%.
The preparation method of the whitening cream comprises the following steps:
s1, adding cetyl stearyl alcohol, squalane and shea butter into an oil phase pot, heating to 75 ℃, stirring at the speed of 400r/min for 22min to obtain an oil phase;
s2, putting deionized water into a water phase pot, adding glycerol, hydroxyethyl cellulose and Tween 60, heating to 75 ℃, stirring at the stirring speed of 1600r/min for 8min to obtain a water phase;
s3, adding the oil phase obtained in the step S1 into the water phase obtained in the step S2, and homogenizing at the homogenizing speed of 3200r/min for 10min to obtain a homogeneous liquid;
s4 cooling the homogenized solution obtained in step S3 to 45 deg.C, adding the composition with seven whitening effects, homogenizing at 3000r/min for 6min, adding triethanolamine, phenoxyethanol and essence, stirring, and cooling to room temperature.
Comparative example 1 composition having seven whitening effects
The composition with seven whitening effects comprises the following components in parts by weight:
10 parts of antioxidant, 4 parts of melanin synthesis inhibitor, 2 parts of enzyme inhibitor, 1 part of melanin polymer inhibitor, 6 parts of melanin reducer and 3 parts of metabolism promoter.
The compositions of the antioxidant, melanin synthesis inhibitor, enzyme inhibitor, melanin polymerization inhibitor, melanin reducing agent and metabolism promoter were similar to those of example 3.
The preparation method of the composition having seven whitening effects is similar to example 3.
The difference from example 3 is that no melanin transfer inhibitor was added.
Comparative example 2, a composition having seven-fold whitening efficacy
The composition with seven whitening effects comprises the following components in parts by weight:
10 parts of antioxidant, 4 parts of melanin synthesis inhibitor, 2 parts of enzyme inhibitor, 6 parts of melanin reducer, 2 parts of melanin transfer inhibitor and 3 parts of metabolism promoter.
The compositions of the antioxidant, melanin synthesis inhibitor, enzyme inhibitor, melanin reducing agent, melanin transfer inhibitor and metabolism promoter were similar to those of example 3.
The preparation method of the composition having seven whitening effects is similar to example 3.
The difference from example 3 is that no melanin polymerization inhibitor was added.
Comparative example 3, composition having seven-fold whitening efficacy
The composition with seven whitening effects comprises the following components in parts by weight:
10 parts of antioxidant, 4 parts of melanin synthesis inhibitor, 2 parts of enzyme inhibitor, 1 part of melanin polymer inhibitor, 6 parts of melanin reducer and 2 parts of melanin transfer inhibitor.
The compositions of the antioxidant, melanin synthesis inhibitor, enzyme inhibitor, melanin polymerization inhibitor, melanin reducing agent and melanin transfer inhibitor were similar to those of example 3.
The difference from example 3 is that no metabolic promoter was added.
Comparative example 4 whitening cream
The whitening cream comprises the following components in percentage by mass: 6% of the composition with seven-fold whitening effect prepared in comparative example 1, 4% of cetyl stearate alcohol, 6% of squalane, 4% of shea butter, 7% of glycerol, 0.1% of hydroxyethyl cellulose, 600.05% of tween, 0.1% of triethanolamine, 0.06% of phenoxyethanol, 0.05% of essence and 72.64% of deionized water.
The preparation method of the whitening cream is similar to that of example 6.
Comparative example 5, whitening cream
The whitening cream comprises the following components in percentage by mass: 6% of the composition with seven-fold whitening effect prepared in comparative example 2, 4% of cetyl stearate alcohol, 6% of squalane, 4% of shea butter, 7% of glycerol, 0.1% of hydroxyethyl cellulose, 600.05% of tween, 0.1% of triethanolamine, 0.06% of phenoxyethanol, 0.05% of essence and 72.64% of deionized water.
The preparation method of the whitening cream is similar to that of example 6.
Comparative example 6, whitening cream
The whitening cream comprises the following components in percentage by mass: 6% of the composition with seven-fold whitening effect prepared in comparative example 3, 4% of cetyl stearate alcohol, 6% of squalane, 4% of shea butter, 7% of glycerol, 0.1% of hydroxyethyl cellulose, 600.05% of tween, 0.1% of triethanolamine, 0.06% of phenoxyethanol, 0.05% of essence and 72.64% of deionized water.
The preparation method of the whitening cream is similar to that of example 6.
Test example I evaluation of whitening Effect
1. Test subjects: whitening creams prepared in example 4, example 5, example 6 and comparative example 6.
2. The test method comprises the following steps:
40 female subjects with no obvious difference in skin types are selected to participate in the test, the female subjects are 28-35 years old, and the exclusion conditions of the female subjects meet the inclusion and exclusion standards of 'cosmetic contact dermatitis diagnosis standard and treatment principle'. The test part is the inner side of the crank arm, the left arm and the right arm are randomly arranged to be a test area, before the test, the skin melanin content MI value of the test part of each test subject is tested by using a skin melanin and heme tester, all the test subjects are randomly divided into 4 groups, 10 persons in each group are respectively an example 4 group, an example 5 group, an example 6 group and a comparative example 6 group, corresponding whitening cream is respectively used, the whitening cream is coated once at night and is continuously used for 8 weeks, and other cosmetics are not used on the test part during the test period. And testing the MI value of the skin melanin content of the tested part of each tested subject by using a skin melanin tester. The test site is washed before the MI value of the melanin content of the skin is tested.
3. And (3) test results:
the test results are shown in table 1.
Table 1: effect of whitening cream on MI value of skin melanin content
As can be seen from table 1, the MI values of the skin melanin contents of the subjects who used the whitening creams prepared in examples 4 to 6 of the present invention were significantly reduced, which indicates that the whitening creams of the present invention have excellent whitening effects, and the whitening effects are more significant with the lapse of time; among them, the embodiment 6 has the best effect and is the best embodiment of the invention; compared with the comparative example 6 group, the subjects in the example 6 group had lower MI values of skin melanin contents, and thus it can be seen that the whitening cream provided by the present invention has a significant whitening effect.
Test example two, evaluation of Using effects
1. Test subjects: whitening creams prepared in example 6, comparative example 4, comparative example 5 and comparative example 6.
2. The test method comprises the following steps:
80 female subjects with no obvious difference in skin texture were selected to participate in the test and randomly divided into four groups, example 6 group and comparative examples 4-6 group, wherein 20 persons in each group were applied with the corresponding whitening cream once at night and continuously used for 12 weeks, and no other cosmetic was applied to the tested part during the test period.
Effect judgment standard: the effect is shown: after 12 weeks of use, the whiteness and the skin color uniformity are obviously improved, and the spots and darkness are obviously improved; improvement: after 12 weeks of use, the whiteness and the skin color uniformity are improved, and the spots and darkness are improved; and (4) invalidation: after 12 weeks of use, there was no change in whiteness and skin tone uniformity, blotches, and darkness.
3. And (3) test results:
the test results are shown in table 2.
Table 2: comparison of usage effects
As can be seen from table 2, the whitening cream prepared in example 6 of the present invention can effectively improve whiteness, uniformity of skin color, spots and darkness; the whitening cream of the comparative example 4 lacks a melanin transfer inhibitor, the whitening cream of the comparative example 5 lacks a melanin polymer inhibitor, and the whitening cream of the comparative example 6 lacks a metabolism promoter, so that the effects of improving whiteness and skin color uniformity, and spots and darkness are not as good as those of the whitening cream of the example 6, which shows that the formula components of the whitening cream are synergistic with each other to play a better effect. Meanwhile, all the subjects have no allergic phenomena such as skin itch, stabbing pain, red swelling and the like. Therefore, the whitening cream is mild and safe and can be used for a long time.
Claims (10)
1. The composition with seven whitening effects is characterized by comprising the following components in parts by weight: 8-12 parts of antioxidant, 2-5 parts of melanin synthesis inhibitor, 1-3 parts of enzyme inhibitor, 1-2 parts of melanin polymer inhibitor, 4-7 parts of melanin reducer, 2-4 parts of melanin transfer inhibitor and 3-5 parts of metabolism promoter.
2. The composition with seven-fold whitening effect according to claim 1, which is characterized by comprising the following components in parts by weight:
10 parts of antioxidant, 4 parts of melanin synthesis inhibitor, 2 parts of enzyme inhibitor, 1 part of melanin polymer inhibitor, 6 parts of melanin reducer, 2 parts of melanin transfer inhibitor and 3 parts of metabolism promoter.
3. The composition with seven-fold whitening efficacy according to claim 1 or 2, wherein the antioxidant is one or more of superoxide dismutase, hesperidin, astaxanthin, 2-O-ethyl ascorbic acid, sodium ascorbyl phosphate, lipoic acid, licorice extract, rhodiola rosea extract, grape seed extract, peony root extract, dimethyl methoxy chromanol, maritime pine bark/bud extract, collard extract, aceous acerola extract;
the melanin synthesis inhibitor is one or more of ascorbyl tetraisopalmitate, phloretin, chamomile extract, saururus chinensis extract, camellia extract, narcissus extract, oldenlandia diffusa extract and cnidium officinale root water;
the enzyme inhibitor is one or more of methyl gentisate, glucosamine, tunicamycin, licoflavone, birch extract, arbutin, strawberry polyphenol, rhizoma Ligustici Chuanxiong extract, paper mulberry extract, emblic leafflower extract, gallic acid, oriental cherry extract, glabridin, dianella ensifolia extract, 4-butyl resorcinol, 4-hexyl resorcinol, diglucosyl gallic acid, radix Scutellariae extract, radix Mori extract, palmitoyl proline sodium, flos Nymphaeae extract, Salicornia herbacea extract, ursolic acid, and kojic acid dipalmitate.
4. The composition with seven-fold whitening efficacy according to claim 1 or 2, wherein the melanin polymerization inhibitor is one or more of 3-O-ethyl ascorbic acid, kojic acid, green tea extract, saxifrage extract, scutellaria baicalensis extract;
the melanin reducer is one or more of ascorbic acid, vitamin E, procyanidine, ellagic acid, zinc sulfate, ferulic acid, curcumin, fructus Citri extract, tranexamic acid, and Uygur herba Hedyotidis Diffusae extract;
the melanin transfer inhibitor is one or more of vitamin A acid, linoleic acid, Thymus serpyllum extract, semen glycines extract, fructus Citri Sarcodactylis extract, magnesium ascorbyl phosphate, ascorbyl palmitate, nicotinamide, Magnolia sieboldii extract, Prunus cerasifera extract, resveratrol, and plankton extract;
the metabolism promoter is one or more of lactic acid, keratinase, polyvinyl alcohol, allantoin, 4-methoxy potassium salicylate, salicylic acid, azelaic acid, oxothiazolidine carboxylic acid, glycolic acid, gluconolactone, lactobionic acid, white willow bark extract, and semen Nelumbinis fermentation liquid.
5. The composition with seven-fold whitening effect according to claim 3, wherein the antioxidant comprises the following components in parts by weight: 5-8 parts of astaxanthin, 2-5 parts of sodium ascorbyl phosphate, 3-6 parts of a licorice extract and 1-2 parts of dimethylmethoxychromanol;
the melanin synthesis inhibitor is prepared from phloretin, a saururus chinensis extract and a daffodil extract according to a mass ratio of 2-4: 5-8: 10-15;
the enzyme inhibitor comprises the following components in parts by weight: 1-2 parts of licorice flavone, 4-7 parts of strawberry polyphenol, 3-5 parts of oriental cherry extract, 2-3 parts of diglucosyl gallic acid and 1-2 parts of sodium palmitoyl prolinate.
6. The composition having seven-fold whitening effects according to claim 4, wherein the melanin polymerization inhibitor is prepared from kojic acid, saxifrage extract and scutellaria baicalensis extract in a mass ratio of 5-8: 2-3: 1-2; the melanin reducer is prepared from vitamin E, curcumin and citron extracts in a mass ratio of (8-10): 4-6: 1-3; the melanin transfer inhibitor is prepared from linoleic acid, bergamot fruit extract and magnolia sieboldii extract according to the mass ratio of 5-8: 3-5: 2-4; the metabolism promoter is prepared from allantoin, glycolic acid and white willow bark extract according to a mass ratio of 1: 2-3: 9-12.
7. The method for preparing the composition having seven whitening effects according to any one of claims 1 to 6, comprising the steps of:
(1) uniformly mixing an antioxidant, a melanin synthesis inhibitor, an enzyme inhibitor, a melanin polymer inhibitor, a melanin reducing agent, a melanin transfer inhibitor and a metabolism promoter to obtain a mixture;
(2) and (2) adding a carboxymethyl chitosan aqueous solution with the mass concentration of 5% into the mixture obtained in the step (1), wherein the amount of the carboxymethyl chitosan aqueous solution is 10-15 times of that of the mixture obtained in the step (1), homogenizing at the homogenizing speed of 1500-2500r/min for 8-15min, and spray drying to obtain the carboxymethyl chitosan/carboxymethyl chitosan.
8. Use of the composition having seven whitening effects according to any one of claims 1 to 6 for preparing a whitening cosmetic.
9. The whitening cream is characterized by comprising the following components in percentage by mass: the composition with seven-fold whitening effect according to any one of claims 1 to 6, 5 to 8 percent of cetyl stearate alcohol, 2 to 5 percent of squalane, 5 to 7 percent of shea butter, 5 to 9 percent of glycerol, 0.1 to 0.3 percent of hydroxyethyl cellulose, 0.1 to 0.1 percent of tween 600.05, 0.1 to 0.3 percent of triethanolamine, 0.05 to 0.1 percent of phenoxyethanol, 0.05 to 0.1 percent of essence, and 65.1 to 79.65 percent of deionized water.
10. The whitening cream according to claim 9, characterized by comprising the following components in percentage by mass: the composition with seven-fold whitening effect according to any one of claims 1 to 6, 4% of cetearyl alcohol, 6% of squalane, 4% of shea butter, 7% of glycerol, 0.1% of hydroxyethyl cellulose, 600.05% of tween, 0.1% of triethanolamine, 0.06% of phenoxyethanol, 0.05% of essence and 72.64% of deionized water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911088331.4A CN110859772A (en) | 2019-11-08 | 2019-11-08 | Composition with seven whitening effects and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911088331.4A CN110859772A (en) | 2019-11-08 | 2019-11-08 | Composition with seven whitening effects and preparation method and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110859772A true CN110859772A (en) | 2020-03-06 |
Family
ID=69654477
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201911088331.4A Pending CN110859772A (en) | 2019-11-08 | 2019-11-08 | Composition with seven whitening effects and preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110859772A (en) |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111388367A (en) * | 2020-03-25 | 2020-07-10 | 江南大学 | Composition for inhibiting melanin at multiple target points, preparation method and application of composition in cosmetics |
| CN111616980A (en) * | 2020-07-13 | 2020-09-04 | 华熙生物科技股份有限公司 | Complex enzyme preparation, preparation method thereof and application thereof in tattooing |
| CN111658585A (en) * | 2020-06-24 | 2020-09-15 | 珠海美逸生物科技有限公司 | Whitening and spot-fading composition and preparation method thereof |
| CN112386552A (en) * | 2020-12-08 | 2021-02-23 | 广州名妆化妆品制造有限公司 | Preparation method of compound freckle-removing and whitening composition |
| CN112656746A (en) * | 2021-01-07 | 2021-04-16 | 美丽链接生物科技研究院(广东)有限公司 | Whitening and freckle-removing cream containing blackberry lily root extract |
| CN112842960A (en) * | 2021-02-03 | 2021-05-28 | 北京健讯医药科技有限公司 | Cosmetic composition with ultraviolet resistance, whitening and aging resistance |
| CN113197811A (en) * | 2021-05-27 | 2021-08-03 | 广州市南方医康生物科技有限公司 | Cosmetic with whitening and freckle removing effects and preparation method thereof |
| CN113975215A (en) * | 2021-11-18 | 2022-01-28 | 广州梵之容化妆品有限公司 | Whitening cream and preparation method thereof |
| CN114344209A (en) * | 2021-12-23 | 2022-04-15 | 健合香港有限公司 | Composition, preparation method and application thereof |
| CN114533618A (en) * | 2022-03-21 | 2022-05-27 | 美出莱(杭州)化妆品有限责任公司 | Whitening and repairing composition and preparation method and application thereof |
| CN114533614A (en) * | 2022-02-24 | 2022-05-27 | 武汉百思凯瑞生物科技有限公司 | Whitening active peptide nano composition and preparation method and application thereof |
| CN115068385A (en) * | 2022-07-11 | 2022-09-20 | 广州市韵柯莱化妆品科技有限公司 | Whitening essence and preparation method thereof |
| WO2023103594A1 (en) * | 2021-12-10 | 2023-06-15 | 懿奈(上海)生物科技有限公司 | Composition for promoting antioxidase expression and use thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107582438A (en) * | 2017-10-24 | 2018-01-16 | 深圳市仙迪化妆品有限公司 | A kind of skin moisturizing cosmetics composition and its preparation technology containing shea butter |
| CN108261341A (en) * | 2018-02-12 | 2018-07-10 | 苏州纳晶医药技术有限公司 | Two-component is used to correct the long-acting water laser accunputure agent of whitening of wrinkle of skin |
| CN109431844A (en) * | 2018-11-29 | 2019-03-08 | 浙江泰达作物科技有限公司 | A kind of whitening spot-eliminating composition and application thereof |
-
2019
- 2019-11-08 CN CN201911088331.4A patent/CN110859772A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107582438A (en) * | 2017-10-24 | 2018-01-16 | 深圳市仙迪化妆品有限公司 | A kind of skin moisturizing cosmetics composition and its preparation technology containing shea butter |
| CN108261341A (en) * | 2018-02-12 | 2018-07-10 | 苏州纳晶医药技术有限公司 | Two-component is used to correct the long-acting water laser accunputure agent of whitening of wrinkle of skin |
| CN109431844A (en) * | 2018-11-29 | 2019-03-08 | 浙江泰达作物科技有限公司 | A kind of whitening spot-eliminating composition and application thereof |
Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111388367B (en) * | 2020-03-25 | 2021-09-24 | 江南大学 | Composition for inhibiting melanin at multiple target points, preparation method and application of composition in cosmetics |
| CN111388367A (en) * | 2020-03-25 | 2020-07-10 | 江南大学 | Composition for inhibiting melanin at multiple target points, preparation method and application of composition in cosmetics |
| CN111658585A (en) * | 2020-06-24 | 2020-09-15 | 珠海美逸生物科技有限公司 | Whitening and spot-fading composition and preparation method thereof |
| CN111616980B (en) * | 2020-07-13 | 2023-02-14 | 华熙生物科技股份有限公司 | Complex enzyme preparation, preparation method thereof and application thereof in tattooing |
| CN111616980A (en) * | 2020-07-13 | 2020-09-04 | 华熙生物科技股份有限公司 | Complex enzyme preparation, preparation method thereof and application thereof in tattooing |
| CN112386552A (en) * | 2020-12-08 | 2021-02-23 | 广州名妆化妆品制造有限公司 | Preparation method of compound freckle-removing and whitening composition |
| CN112656746A (en) * | 2021-01-07 | 2021-04-16 | 美丽链接生物科技研究院(广东)有限公司 | Whitening and freckle-removing cream containing blackberry lily root extract |
| CN112656746B (en) * | 2021-01-07 | 2023-11-28 | 美丽链接生物科技研究院(广东)有限公司 | Whitening and freckle-removing cream containing blackberry lily root extract |
| CN112842960A (en) * | 2021-02-03 | 2021-05-28 | 北京健讯医药科技有限公司 | Cosmetic composition with ultraviolet resistance, whitening and aging resistance |
| CN113197811A (en) * | 2021-05-27 | 2021-08-03 | 广州市南方医康生物科技有限公司 | Cosmetic with whitening and freckle removing effects and preparation method thereof |
| CN113975215A (en) * | 2021-11-18 | 2022-01-28 | 广州梵之容化妆品有限公司 | Whitening cream and preparation method thereof |
| WO2023103594A1 (en) * | 2021-12-10 | 2023-06-15 | 懿奈(上海)生物科技有限公司 | Composition for promoting antioxidase expression and use thereof |
| CN114344209B (en) * | 2021-12-23 | 2023-10-20 | 健合香港有限公司 | Composition for delaying aging, preparation method and application thereof |
| CN114344209A (en) * | 2021-12-23 | 2022-04-15 | 健合香港有限公司 | Composition, preparation method and application thereof |
| CN114533614A (en) * | 2022-02-24 | 2022-05-27 | 武汉百思凯瑞生物科技有限公司 | Whitening active peptide nano composition and preparation method and application thereof |
| CN114533614B (en) * | 2022-02-24 | 2023-09-01 | 武汉百思凯瑞生物科技有限公司 | Whitening active peptide nano composition and preparation method and application thereof |
| CN114533618A (en) * | 2022-03-21 | 2022-05-27 | 美出莱(杭州)化妆品有限责任公司 | Whitening and repairing composition and preparation method and application thereof |
| CN115068385A (en) * | 2022-07-11 | 2022-09-20 | 广州市韵柯莱化妆品科技有限公司 | Whitening essence and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN110859772A (en) | Composition with seven whitening effects and preparation method and application thereof | |
| CN101904809B (en) | Skin whitening composition | |
| CN107242982B (en) | Fair and bright emulsion and preparation method thereof | |
| AU2007361455A1 (en) | Topical cosmetic skin lightening compositions and methods of use thereof | |
| CN107374988B (en) | Preparation method of nonionic vesicle with whitening effect | |
| CN110755351A (en) | Whitening, moisturizing and repairing composition and application thereof | |
| CN104825382A (en) | Biotechnology skin-whitening cosmetics | |
| CN110946796A (en) | Whitening composition containing endothelin antagonist and preparation method and application thereof | |
| CN110638722A (en) | Anti-aging cosmetic and preparation method thereof | |
| CN111603406A (en) | Cosmetic composition containing penetration enhancer, essence and preparation method thereof | |
| KR101702138B1 (en) | Use of myrtle extract as depigmenting agent | |
| CN109771351A (en) | A kind of Whitening, spot composition and its application | |
| CN102232917A (en) | Use of traditional Chinese drug compound extract in preparing whitening and moisturizing products | |
| CN102342903B (en) | Skincare composition as well as use and method of same for preventing and delaying skin aging | |
| KR20170137412A (en) | Composition for improving skin condition comprising herb extracts mixture | |
| CN110664695A (en) | Anti-oxidation whitening cream containing tea polyphenol | |
| CN104800135A (en) | Chinese herbal cosmetic with spot banishing, moisturizing and sunscreen effects | |
| CN110652475A (en) | Application of nardostachys chinensis extract | |
| CN115475119A (en) | Composition for whitening and brightening skin and preparation method and application thereof | |
| CN114533613A (en) | Whitening cosmetic composition and preparation method and application thereof | |
| KR20170136919A (en) | Composition for improving skin condition comprising herb extracts mixture | |
| CN108653144B (en) | Whitening cosmetic | |
| CN113143824A (en) | Composition with whitening effect and preparation method thereof | |
| CN110960478A (en) | Freckle-removing cream containing umbilical cord extract and preparation method thereof | |
| CN113876618B (en) | Skin whitening, antioxidation soluble beauty microneedle patch composition and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20200306 |