CN110749730A - Sample analyzer and cleaning method thereof - Google Patents
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- CN110749730A CN110749730A CN201910667216.6A CN201910667216A CN110749730A CN 110749730 A CN110749730 A CN 110749730A CN 201910667216 A CN201910667216 A CN 201910667216A CN 110749730 A CN110749730 A CN 110749730A
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Abstract
The application discloses sample analysis device and cleaning method thereof, the device includes: the immunoassay sub-device also comprises a controller which is connected with the immunoassay sub-device and used for controlling the immunoassay sub-device to detect a first background voltage value of the immunoassay sub-device when no sample to be detected exists, determining a cleaning mode of the immunoassay sub-device according to the comparison between the first background voltage value and a preset background voltage threshold value and sending a corresponding cleaning instruction; and the cleaning subsystem is connected with the controller and is used for receiving the cleaning instruction sent by the controller and responding to the cleaning instruction to correspondingly clean the immunoassay sub-device. Through the mode, on the basis of guaranteeing the accuracy of cleaning effect, device detection precision and sample detection result, the application can provide technical support for saving specific cleaning liquid and reducing the risk of pollution of the specific cleaning liquid.
Description
Technical Field
The present application relates to the field of immunoassay technologies, and in particular, to a sample analyzer and a cleaning method thereof.
Background
The immunoassay device performs latex immunoreaction with a sample to be detected by using a latex immunoreaction reagent, and completes latex immunoassay by using a detection method of laser scattering or transmission. In order to facilitate maintenance and reuse of the immunoassay device, to prolong the service life of the immunoassay device, and to ensure reliability of the analysis result of the sample, the immunoassay device generally needs to be cleaned.
In the prior art, a conventional hemolyzing agent or a test solution after a conventional reaction of blood is used to clean an immunoassay device, that is, the immunoassay device is cleaned after each immunoassay reaction and analysis. However, the inventors of the present application found in a long-term development process that the above cleaning method has the following disadvantages: firstly, the consumption of the conventional hemolytic agent of blood will increase, and the cost will greatly increase, secondly the hemolytic ability of the general phase ratio immune hemolytic agent of blood is stronger, and uses the conventional hemolytic agent of blood or the test solution after the conventional reaction of blood to wash at every turn, has increased the risk to latex immune reagent pollution to cause the unreliable of result.
Disclosure of Invention
The technical problem that this application mainly solved provides a sample analysis device and cleaning method thereof, can guarantee on the basis of clean effect, device detection precision and sample testing result accuracy, provide technical support for practicing thrift specific washing liquid, reducing the risk that specific washing liquid pollutes.
In order to solve the technical problem, the application adopts a technical scheme that: providing a sample analysis device comprising an immunoassay sub-device, the device further comprising: the controller is connected with the immunoassay sub-device and is used for controlling the immunoassay sub-device to detect a first background voltage value of the immunoassay sub-device when no sample to be detected exists, determining a cleaning mode of the immunoassay sub-device according to the comparison between the first background voltage value and a preset background voltage threshold value and sending a corresponding cleaning instruction; and the cleaning subsystem is connected with the controller and used for receiving the cleaning instruction sent by the controller and responding to the cleaning instruction to correspondingly clean the immunoassay sub-device.
In order to solve the above technical problem, another technical solution adopted by the present application is: there is provided a method of cleaning a sample analysis device, the method being adapted for use with a sample analysis device as described above, the method comprising: controlling the immunoassay sub-device to detect a first background voltage value of the immunoassay sub-device when no sample to be detected exists; determining a cleaning mode of the immunoassay sub-device according to the comparison between the first background voltage value and a preset background voltage threshold value and sending a corresponding cleaning instruction; and responding to the cleaning instruction to correspondingly clean the immunoassay sub-device.
In order to solve the above technical problem, another technical solution adopted by the present application is: there is provided a sample analysis device comprising:
the immunoassay sub-device comprises a colorimetric pool, and a laser and a photoelectric receiver which are respectively arranged on two sides of the colorimetric pool, wherein the colorimetric pool is used for containing soaking liquid when the colorimetric pool is not used for detection, the colorimetric pool is used for discharging the soaking liquid when the colorimetric pool is used for detection, and sequentially containing base liquid and a sample to be detected, the laser is used for emitting laser towards the colorimetric pool so that the photoelectric receiver obtains an optical signal and converts the optical signal into an electric signal, and the electric signal obtained when the photoelectric receiver discharges the soaking liquid and only contains the base liquid is a first base electric signal;
and the controller is used for receiving the first background electric signal, comparing the first background electric signal with a preset background electric signal and sending a corresponding cleaning instruction.
In order to solve the above technical problem, another technical solution adopted by the present application is: there is provided a sample analysis device comprising:
a container at least used for containing a base liquid and a sample to be detected;
the photoelectric detection assembly is used for detecting when the container only contains the base liquid to obtain a first base electric signal, and detecting when the container contains the base liquid and a sample to be detected to obtain a sample detection electric signal;
and the controller is used for sending a first instruction to clean or not clean the container in a first cleaning mode when the first background electric signal is smaller than a preset background electric signal threshold value, otherwise sending a second instruction to clean the container in a second cleaning mode, wherein the cleaning intensity of the specific substance in the second cleaning mode is greater than that in the first cleaning mode.
The beneficial effect of this application is: in contrast to the prior art, the sample analyzer of the present application includes an immunoassay sub-device, and further includes: the controller is connected with the immunoassay sub-device and is used for controlling the immunoassay sub-device to detect a first background voltage value of the immunoassay sub-device when no sample to be detected exists, determining a cleaning mode of the immunoassay sub-device according to the comparison between the first background voltage value and a preset background voltage threshold value and sending a corresponding cleaning instruction; and the cleaning subsystem is connected with the controller and used for receiving the cleaning instruction sent by the controller and responding to the cleaning instruction to correspondingly clean the immunoassay sub-device. The device detects a first background voltage value of the immunoassay sub-device when no sample to be detected exists, determines a cleaning mode of the immunoassay sub-device according to the comparison between the first background voltage value and a preset background voltage threshold value and sends a corresponding cleaning instruction to correspondingly clean the immunoassay sub-device, and determines the cleaning mode of the immunoassay sub-device according to the first background voltage value and the preset background voltage threshold value, namely determines the cleaning mode according to the actual cleaning state and the actual detection requirement of the immunoassay sub-device instead of only fixedly adopting a certain cleaning mode for cleaning.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed to be used in the description of the embodiments are briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present application, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts. Wherein:
FIG. 1 is a schematic structural view of an embodiment of a sample analyzer according to the present application;
FIG. 2 is a schematic structural view of another embodiment of a sample analyzer according to the present application;
FIG. 3 is a schematic view of the structure of another embodiment of the sample analyzer of the present application;
FIG. 4 is a schematic flow chart illustrating one embodiment of a method for cleaning a sample analyzer of the present application;
FIG. 5 is a schematic flow chart diagram illustrating another embodiment of a method for cleaning a sample analyzer according to the present application;
FIG. 6 is a schematic structural view of another embodiment of a sample analyzer according to the present application;
FIG. 7 is a schematic structural view of another embodiment of the sample analyzer of the present application.
Detailed Description
The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and not all the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
Referring to fig. 1, fig. 1 is a schematic structural diagram of an embodiment of a sample analyzer according to the present application, the sample analyzer including: an immunoassay sub-device 1, a controller 2, and a washing sub-system 3.
The controller 2 is connected with the immunoassay sub-device 1, and is used for controlling the immunoassay sub-device 1 to detect a first background voltage value (or current value) of the immunoassay sub-device 1 when a sample to be detected (wherein the sample to be detected can be whole blood, plasma, serum, diluted whole blood, plasma, serum, and the like) does not exist (wherein the immunoassay sub-device 1 can be added with three types of liquid, including soak solution during non-detection, base solution and the sample to be detected which are sequentially added during detection, the soak solution can adopt a conventional cleaning solution which is well known to a person skilled in the art, such as sodium chloride, the first background voltage value refers to a voltage value obtained when only the base solution is added, the base solution can be one, two or more than three types, such as a latex reagent, and is mainly used for immunological binding reaction with the sample), and determining the cleaning mode of the immunoassay sub-device 1 according to the comparison between the first background voltage value and the preset background voltage threshold value, and sending a corresponding cleaning instruction.
The cleaning subsystem 3 is connected with the controller 2 and is used for receiving the cleaning instruction sent by the controller 2 and responding to the cleaning instruction to correspondingly clean the immunoassay sub-device 1.
The immunoassay sub-device 1 is used for conducting an immunoassay, such as a latex immunoassay, on a sample to be detected. The first background voltage value is a background voltage value when the immunoassay sub-device 1 does not have the sample to be detected, and can represent the current cleaning state of the immunoassay sub-device 1. The preset background voltage threshold may represent the actual detection requirements of the sample and/or instrument, for example: the accuracy of the detection result of the sample, the detection precision of the instrument, and the like. The preset background voltage threshold may be pre-stored locally, or user input, or imported locally from elsewhere, etc.
The washing subsystem 3 is connected to the controller 2, and receives a washing command transmitted from the controller 2, and performs corresponding washing of the immunoassay sub-apparatus 1 in response to the washing command. If the original analyzing device itself includes a part of the cleaning assembly, the cleaning subsystem 3 may include the part of the cleaning assembly, and the cleaning subsystem 3 may also include a new cleaning assembly, and the specific configuration needs to be determined according to actual situations, which is not limited herein.
The sample analysis device of the embodiment of the present application includes an immunoassay sub-device, and further includes: the controller is connected with the immunoassay sub-device and is used for controlling the immunoassay sub-device to detect a first background voltage value of the immunoassay sub-device when no sample to be detected exists, determining a cleaning mode of the immunoassay sub-device according to the comparison between the first background voltage value and a preset background voltage threshold value and sending a corresponding cleaning instruction; and the cleaning subsystem is connected with the controller and used for receiving the cleaning instruction sent by the controller and responding to the cleaning instruction to correspondingly clean the immunoassay sub-device. The device detects a first background voltage value of the immunoassay sub-device when no sample to be detected exists, determines a cleaning mode of the immunoassay sub-device according to the comparison between the first background voltage value and a preset background voltage threshold value and sends a corresponding cleaning instruction to correspondingly clean the immunoassay sub-device, and determines the cleaning mode of the immunoassay sub-device according to the first background voltage value and the preset background voltage threshold value, namely determines the cleaning mode according to the actual cleaning state and the actual detection requirement of the immunoassay sub-device instead of only fixedly adopting a certain cleaning mode for cleaning.
The cleaning mode comprises a first cleaning mode and a second cleaning mode, the first cleaning mode is to clean the immunoassay sub-device by adopting a first cleaning solution, and the second cleaning mode is to clean the immunoassay sub-device by adopting a second cleaning solution.
Further, the first cleaning liquid is a conventional cleaning liquid, and the second cleaning liquid is a special cleaning liquid.
The conventional cleaning solution is low in price generally, the special cleaning solution is high in price, different cleaning solutions are adopted to clean the immunoassay sub-device respectively according to different cleaning modes, the using amount of the special cleaning solution can be saved on the basis of meeting the user demands, and therefore the cleaning cost is saved. The preset background voltage threshold value can ensure the precision of the detection result of the immunoassay sub-device and the accuracy of the detection result of the sample to be detected. By the mode, the cleaning cost can be saved on the basis of ensuring the detection result precision of the immunoassay sub-device and the detection result accuracy of the sample to be detected.
In one embodiment, the preset background voltage threshold M is 90 mv, 95 mv, 100 mv, 105 mv, or 110 mv, etc., and the specific value is not limited in the present invention.
The rationality of limiting the preset background voltage threshold value M reduces the consumption of special cleaning solution for the immunoassay sub-device, saves reagent cost, reduces the risk of reagent pollution, has reliable cleaning effect, and ensures the accuracy of results and the requirement of instrument precision.
In one embodiment, the dedicated wash solution is a wash solution containing a hemolytic agent.
In one embodiment, the controller 2 is specifically configured to control the immunoassay sub-device 1 to detect a first background voltage value of the immunoassay sub-device 1 when there is no sample to be detected at the back, and when the first background voltage value is smaller than a preset background voltage threshold, the controller controls the immunoassay sub-device 1 to detect a next sample to be detected, and determines that a cleaning mode of the immunoassay sub-device 1 after detecting the next sample to be detected is a first cleaning mode, and sends a corresponding first cleaning instruction; the cleaning subsystem 3 receives the first cleaning instruction sent by the controller 2, and responds to the first cleaning instruction to correspondingly clean the immunoassay sub-device 1 after the immunoassay sub-device 1 detects the next sample to be detected.
The controller 2 is further configured to determine that the cleaning mode of the immunoassay sub-device 1 is a second cleaning mode and send a corresponding second cleaning instruction when the first background voltage value is greater than or equal to a preset background voltage threshold value; the washing subsystem 3 receives the second washing command sent by the controller 2 and performs corresponding washing on the immunoassay sub-device 1 in response to the second washing command.
Referring to fig. 2, in one embodiment, the device further comprises a sample providing sub-device 4, an immunoreagent supply device 5, a first wash solution storage sub-device 6, and a second wash solution storage sub-device 7.
The sample providing sub-device 4 is connected with the controller 2, the immunoassay reagent supplying device 5 is respectively connected with the controller 2 and the immunoassay sub-device 1, and the first cleaning solution storage sub-device 6 and the second cleaning solution storage sub-device 7 are both connected with the sample providing sub-device 4; the sample supply sub-assembly 4 supplies the sample to be analyzed to the immunoassay sub-assembly 1 under the control of the controller 2, or supplies the first washing solution in the first washing solution storage sub-assembly 6 to the immunoassay sub-assembly 1 for washing, or supplies the second washing solution in the second washing solution storage sub-assembly 7 (for storing a second washing solution required for washing the immunoassay sub-assembly 1) to the immunoassay sub-assembly 1 for washing; the immunoreagent supply sub-assembly 5 supplies the immunoassay sub-assembly 1 with an immunoreagent (e.g., a hemolyzing agent, a latex reagent, etc.) required for detecting a sample to be analyzed under the control of the controller 2. Wherein the second wash liquid storage sub-assembly 7 is arranged on the path of travel of the sample presentation sub-assembly 4.
In the present embodiment, the sample supply sub-device 4 and the first washing liquid storage sub-device 6 may be configured as the original sample analyzer itself, and the second washing liquid storage sub-device 7 is added to the original configuration, and the sample supply sub-device 4 is still used to supply the second washing liquid in the second washing liquid storage sub-device 7 to the immunoassay sub-device 1 for washing. That is, the washing subsystem actually comprises the sample presentation sub-arrangement 4, the first washing liquid storage sub-arrangement 6 and the second washing liquid storage sub-arrangement 7, in such a way that, on the one hand, existing structural components of the original sample analysis device can be fully reused and, on the other hand, the structure of the sample analysis device can be made as compact as possible.
Referring to fig. 3, in one embodiment, the device further comprises a sample providing sub-device 4, an immunoreagent supplying sub-device 5, a second wash solution supplying sub-device 8, a first wash solution storing sub-device 6, and a second wash solution storing sub-device 7.
The sample providing sub-device 4 is connected with the controller 2, the immunoreagent supplying sub-device 5 is respectively connected with the controller 2 and the immunoassay sub-device 1, the second cleaning solution supplying sub-device 8 (comprising a pipeline, a valve, a syringe or a quantitative pump and other liquid path elements which are well known by a person skilled in the art) is respectively connected with the controller 2 and the immunoassay sub-device 1, the first cleaning solution storage sub-device 6 is connected with the sample providing sub-device 4, and the second cleaning solution storage sub-device 7 is connected with the second cleaning solution supplying sub-device 8; the sample supply sub-assembly 4 supplies the sample to be tested to the immunoassay sub-assembly 1 or supplies the first washing solution in the first washing solution storage sub-assembly 6 to the immunoassay sub-assembly 1 for washing under the control of the controller 2; the second washing liquid supply sub-assembly 8 supplies the second washing liquid in the second washing liquid storage sub-assembly 7 to the immunoassay sub-assembly 1 for washing under the control of the controller 2; the immunoreagent supply sub-unit 5 supplies the immunoassay sub-unit 1 with an immunoreagent necessary for detecting a sample to be detected under the control of the controller 2. Wherein the second washing liquid storage sub-device 7 is provided inside or outside the sample analysis device.
In the present embodiment, the sample supply sub-apparatus 4 and the first washing liquid storage sub-apparatus 6 may be configured as the original sample analyzer itself, and the second washing liquid supply sub-apparatus 8 and the second washing liquid storage sub-apparatus 7 are added to the structure, and the second washing liquid in the second washing liquid storage sub-apparatus 7 is supplied to the immunoassay sub-apparatus 1 for washing by the newly added second washing liquid supply sub-apparatus 8 without using the sample supply sub-apparatus 4. That is, the washing subsystem actually comprises the sample supply sub-assembly 4, the first washing liquid storage sub-assembly 6, the second washing liquid supply sub-assembly 8 and the second washing liquid storage sub-assembly 7, in such a way that the sample analysis apparatus can be modified as little as possible, and the original sample analysis apparatus can be simply and conveniently modified.
Further, the sample providing sub-device 4 includes a sampling needle, a driving component and a pipeline.
Referring to fig. 4, fig. 4 is a schematic flow chart of an embodiment of a cleaning method for a sample analyzer according to the present application, which is suitable for use in any one of the above sample analyzers, and the detailed description of the related contents refers to the above device section, which is not repeated herein. The method comprises the following steps:
step S101: and controlling the immunoassay sub-device to detect a first background voltage value of the immunoassay sub-device when the sample to be detected does not exist.
Step S102: and determining a cleaning mode of the immunoassay sub-device and sending a corresponding cleaning instruction according to the first background voltage value and a preset background voltage threshold value.
Step S103: and responding to the cleaning instruction to correspondingly clean the immunoassay sub-device.
The method comprises the steps of controlling an immunoassay sub-device to detect a first background voltage value of the immunoassay sub-device when a sample to be detected does not exist; determining a cleaning mode of the immunoassay sub-device according to the comparison between the first background voltage value and a preset background voltage threshold value and sending a corresponding cleaning instruction; and responding to the cleaning instruction to correspondingly clean the immunoassay sub-device. The method comprises the steps of detecting a first background voltage value of the immunoassay sub-device when no sample to be detected exists, determining a cleaning mode of the immunoassay sub-device according to the comparison between the first background voltage value and a preset background voltage threshold value, sending a corresponding cleaning instruction to correspondingly clean the immunoassay sub-device, and determining the cleaning mode of the immunoassay sub-device according to the first background voltage value and the preset background voltage threshold value, namely determining the cleaning mode according to the actual cleaning state and the actual detection requirement of the immunoassay sub-device instead of only fixedly adopting a certain cleaning mode for cleaning.
The cleaning mode comprises a first cleaning mode and a second cleaning mode, the first cleaning mode is to clean the immunoassay sub-device by adopting a first cleaning solution, and the second cleaning mode is to clean the immunoassay sub-device by adopting a second cleaning solution.
The first cleaning liquid is a conventional cleaning liquid, and the second cleaning liquid is a special cleaning liquid.
The preset background voltage threshold M is 90 mv, 95 mv, 100 mv, 105 mv or 110 mv, etc., and the specific value does not limit the present invention.
Wherein, the special cleaning solution is a cleaning solution containing hemolytic agent. The hemolytic agent can contain quaternary ammonium salt cationic surfactant to dissolve red blood cells, and the liquid containing hemolytic agent components can be directly used for cleaning reaction residues of the immunoassay sub-device; in addition, since the liquid containing the hemolytic agent component is a common liquid in sample analysis, it is not necessary to prepare a special cleaning liquid, and thus the process can be simplified and the reagent cost can be further saved.
Step S101 of controlling the immunoassay sub-device to detect a first background voltage value of the immunoassay sub-device when there is no sample to be detected may specifically include: controlling the immunoassay sub-device to detect a first background voltage value of the immunoassay sub-device after the measurement of the cleaning sample and when the sample to be detected does not exist; step S102 determines a cleaning mode of the immunoassay sub-apparatus according to a comparison between the first background voltage value and a preset background voltage threshold value stored locally, and sends a corresponding cleaning instruction, which may specifically include: when the first background voltage value is smaller than a preset background voltage threshold value, determining that the cleaning mode of the immunoassay sub-device is a first cleaning mode, and sending a corresponding first cleaning instruction, and when the first background voltage value is larger than or equal to the preset background voltage threshold value, determining that the cleaning mode of the immunoassay sub-device is a second cleaning mode, and sending a corresponding second cleaning instruction; step S103, responding to the cleaning instruction to correspondingly clean the immunoassay sub-device, which may specifically include: and responding to the first cleaning instruction to correspondingly clean the immunoassay sub-device, or responding to the second cleaning instruction to correspondingly clean the immunoassay sub-device.
Step S101 of controlling the immunoassay sub-device to detect a background voltage value of the immunoassay sub-device when there is no sample to be detected may specifically include: controlling the immunoassay sub-device to detect a second background voltage value of the immunoassay sub-device before sample detection and when no sample to be detected exists; step S102 determines a cleaning mode of the immunoassay sub-apparatus according to a comparison between the background voltage value and a preset background voltage threshold value, and sends a corresponding cleaning instruction, which may specifically include: when the second background voltage value is smaller than a preset background voltage threshold value, determining that the cleaning mode of the immunoassay sub-device is a first cleaning mode, and sending a corresponding first cleaning instruction, and when the second background voltage value is larger than or equal to the preset background voltage threshold value, determining that the cleaning mode of the immunoassay sub-device is a second cleaning mode, and sending a corresponding second cleaning instruction; step S103, responding to the cleaning instruction to correspondingly clean the immunoassay sub-device, which may specifically include: and responding to the first cleaning instruction to correspondingly clean the immunoassay sub-device, or responding to the second cleaning instruction to correspondingly clean the immunoassay sub-device.
Further, the performing corresponding cleaning on the immunoassay sub-apparatus in response to the first cleaning instruction, or performing corresponding cleaning on the immunoassay sub-apparatus in response to the second cleaning instruction may specifically include:
the sample supply sub-assembly is controlled in response to the first wash instruction to supply the first wash solution in the first wash solution storage sub-assembly to the immunoassay sub-assembly for washing, or the sample supply sub-assembly is controlled in response to the second wash instruction to supply the second wash solution in the second wash solution storage sub-assembly to the immunoassay sub-assembly for washing.
Further, the performing corresponding cleaning on the immunoassay sub-apparatus in response to the first cleaning instruction, or performing corresponding cleaning on the immunoassay sub-apparatus in response to the second cleaning instruction may specifically include:
controlling the sample providing sub-assembly to provide the first wash solution in the first wash solution storage sub-assembly to the immunoassay sub-assembly for washing in response to the first wash instruction; alternatively, the second washing solution supply sub-means is controlled in response to the second washing instruction to supply the second washing solution in the second washing solution storage sub-means to the immunoassay sub-means for washing.
For example, referring to fig. 5, in a practical application, the method may be implemented by the following steps:
step S201: switching an immunoassay mode to detect a first background voltage value in the immunoassay sub-assembly;
step S202: judging whether a first background voltage value of the immunoassay sub-device is smaller than a limited preset background voltage threshold value M;
step S203: if the first background voltage value is smaller than the preset background voltage threshold value M, allowing the sample providing sub-device 1 to collect a sample to be detected and provide the sample to be detected to the immunoassay sub-device, and after the immunoassay sub-device analyzes the sample, discharging sample liquid and cleaning with conventional diluent (namely, first cleaning liquid);
step S204: after the sample is detected, continuously detecting the first background voltage value in the immunoassay sub-device, and returning to the step S202;
step S205: if the first background voltage value of step S202 is greater than or equal to the preset background voltage threshold M, the sample providing sub-device sucks the special cleaning solution from the special cleaning solution storage sub-device (i.e., the second cleaning solution storage sub-device) and conveys the special cleaning solution to the immunoassay sub-device for cleaning;
step S206: after the cleaning is finished, the first background voltage value is continuously detected and the step S202 is returned to.
The rationality of limiting the preset background voltage threshold value M reduces the consumption of special cleaning solution for the immunoassay sub-device, saves reagent cost, reduces the risk of reagent pollution, has reliable cleaning effect, and ensures the accuracy of sample detection results and the requirement of instrument detection result precision.
Referring to fig. 6, the embodiment of the present invention further provides a sample analyzer, which includes an immunoassay sub-device 11, a controller 21, and a washing sub-system 31.
The immunoassay sub-device 11 comprises a colorimetric pool 12, and a laser 14 and a photoelectric receiver 13 which are respectively arranged on two sides of the colorimetric pool 12, wherein the colorimetric pool 12 is used for installing a soaking solution when detection is not performed, the colorimetric pool 12 is used for discharging the soaking solution when detection is performed and sequentially installing a base solution and a sample to be detected, the laser 14 is used for emitting laser towards the colorimetric pool 12 so that the photoelectric receiver 13 obtains an optical signal and converts the optical signal into an electric signal, and the electric signal obtained when the colorimetric pool discharges the soaking solution and only contains the base solution is a first base electric signal by the photoelectric receiver 13; the controller 21 is configured to receive the first background electrical signal, compare the first background electrical signal with a preset background electrical signal, and send a corresponding cleaning instruction; the washing subsystem 31 is configured to perform corresponding washing on the cuvette in response to the washing instruction, wherein:
when the first background electric signal is smaller than the preset background electric signal, the controller 21 sends a first cleaning instruction to enable the cleaning subsystem 11 to clean the cuvette by using a first cleaning solution;
when the first background electric signal is greater than or equal to the preset background electric signal, the controller 21 issues a second cleaning instruction to enable the cleaning subsystem 11 to clean the cuvette with a second cleaning solution, where the cleaning strength of the second cleaning solution to a specific substance is greater than the cleaning strength of the first cleaning solution to the specific substance. The specific substance may be a conjugate of an immune reaction or a reaction residue.
The sample analysis device that this embodiment provided can carry out sample detection when installing the base solution in proper order in colorimetric pool 12 and waiting to detect the sample, and utilize the state judgement when only being equipped with the base solution in colorimetric pool 12 to wash whether need adopt special washing liquid, the mode that adopts special washing liquid to wash or quantitative (for example wash once per 100 samples) to adopt special washing liquid to wash is different from regularly (for example wash once every hour) among the prior art, the device that this embodiment provided more can be accurate judgement whether need adopt special washing liquid to wash, thereby reach the purpose that intelligence triggered special washing liquid and wash, practice thrift special washing liquid.
Referring to fig. 7, the embodiment of the present invention further provides a sample analyzer, which includes a container 25, a photoelectric detection assembly 23, and a controller 22.
Wherein, the container 25 is at least used for containing a base solution and a sample to be detected; the photoelectric detection component 23 is configured to perform detection to obtain a first background electric signal when the container 25 only contains the bottom liquid, and perform detection to obtain a sample detection electric signal when the container 25 contains the bottom liquid and a sample to be detected; the controller 22 is configured to issue a first command to perform a first washing mode or not to wash the container when the first background electric signal is smaller than a preset background electric signal threshold, and otherwise issue a second command to perform a second washing mode, wherein the cleaning intensity of the second washing mode on a specific substance is greater than that of the first washing mode. The first cleaning mode and the second cleaning mode may be performed by the cleaning subsystem 32, and the specific configuration of the cleaning subsystem 32 may refer to the foregoing embodiments, which are not described in detail in this embodiment.
The container 25 may be the colorimetric pool 12 or other reaction pool in the foregoing embodiment, and the components of the base solution and the sample to be detected include, but are not limited to, those described in the above embodiments, and as long as the detection is performed by sequentially adding liquids, whether the second washing mode needs to be activated or not may be determined by comparing the first background electric signal in the intermediate state (i.e., the state in which one, two, or three or more base solutions are added) with the preset background electric signal.
In this embodiment, the container 25 is used to only contain the base solution, and the detection is performed to obtain a first base electrical signal, which is used as a trigger condition for judging whether to adopt a special cleaning solution to perform cleaning, so that the cleaning efficiency can be improved, and the accuracy of the sample detection result and the requirement of the precision of the detection result of the instrument are ensured.
The above description is only for the purpose of illustrating embodiments of the present application and is not intended to limit the scope of the present application, and all modifications of equivalent structures and equivalent processes, which are made by the contents of the specification and the drawings of the present application or are directly or indirectly applied to other related technical fields, are also included in the scope of the present application.
Claims (20)
1. A sample analysis device comprising an immunoassay sub-device, the device further comprising:
the controller is connected with the immunoassay sub-device and is used for controlling the immunoassay sub-device to detect a first background voltage value of the immunoassay sub-device when no sample to be detected exists, determining a cleaning mode of the immunoassay sub-device according to the comparison between the first background voltage value and a preset background voltage threshold value and sending a corresponding cleaning instruction;
and the cleaning subsystem is connected with the controller and used for receiving the cleaning instruction sent by the controller and responding to the cleaning instruction to correspondingly clean the immunoassay sub-device.
2. The device of claim 1, wherein the washing mode comprises a first washing mode and a second washing mode, the first washing mode is for washing the immunoassay sub-device with a first washing solution, and the second washing mode is for washing the immunoassay sub-device with a second washing solution.
3. The apparatus of claim 2, wherein the first cleaning fluid is a regular cleaning fluid and the second cleaning fluid is a specialty cleaning fluid.
4. The apparatus of claim 1, wherein the preset background voltage threshold M is 90 mV, 95 mV, 100 mV, 105 mV, or 110 mV.
5. The device of claim 3, wherein the dedicated wash solution is a wash solution containing a hemolytic agent.
6. The device according to claim 2, wherein the controller is specifically configured to control the immunoassay sub-device to detect a first background voltage value of the immunoassay sub-device after cleaning and when no sample to be detected exists, and when the first background voltage value is smaller than the preset background voltage threshold, the controller controls the immunoassay sub-device to detect a next sample to be detected, determines that a cleaning mode of the immunoassay sub-device after detecting the next sample to be detected is a first cleaning mode, and sends a corresponding first cleaning instruction; the cleaning subsystem receives a first cleaning instruction sent by the controller, responds to the first cleaning instruction, and correspondingly cleans the immunoassay sub-device after the immunoassay sub-device detects the next sample to be detected;
when the first background voltage is greater than or equal to the preset background voltage threshold value, the controller determines that the cleaning mode of the immunoassay sub-device is a second cleaning mode, and sends a corresponding second cleaning instruction; and the cleaning subsystem receives a second cleaning instruction sent by the controller and responds to the second cleaning instruction to correspondingly clean the immunoassay sub-device.
7. The device of claim 2, further comprising a sample providing sub-device, an immunoreagent supplying sub-device, a first wash solution storage sub-device, and a second wash solution storage sub-device,
the sample providing sub-device is respectively connected with the controller and the immunoassay sub-device, the immunoreagent supplying sub-device is respectively connected with the controller and the immunoassay sub-device, and the first cleaning solution storage sub-device and the second cleaning solution storage sub-device are both connected with the sample providing sub-device;
the sample providing sub-device provides a sample to be analyzed to the immunoassay sub-device under the control of the controller, or provides a first cleaning solution in the first cleaning solution storage sub-device to the immunoassay sub-device for cleaning, or provides a second cleaning solution in the second cleaning solution storage sub-device to the immunoassay sub-device for cleaning;
the immune reagent supplying sub-device supplies immune reagents required for detecting the sample to be analyzed to the immune analysis sub-device under the control of the controller;
the second cleaning solution storage sub-device is arranged on a walking path of the sample providing sub-device.
8. The device of claim 2, further comprising a sample providing sub-device, an immunoreagent supplying sub-device, a second wash solution supplying sub-device, a first wash solution storage sub-device, and a second wash solution storage sub-device,
the sample providing sub-device is respectively connected with the controller and the immunoassay sub-device, the immunoreagent supplying sub-device is respectively connected with the controller and the immunoassay sub-device, the second cleaning solution supplying sub-device is respectively connected with the controller and the immunoassay sub-device, the first cleaning solution storage sub-device is connected with the sample providing sub-device, and the second cleaning solution storage sub-device is connected with the second cleaning solution supplying sub-device;
the sample providing sub-device provides a sample to be detected to the immunoassay sub-device under the control of the controller, or provides the first cleaning solution in the first cleaning solution storage sub-device to the immunoassay sub-device for cleaning;
the second cleaning solution supply sub-device supplies the second cleaning solution in the second cleaning solution storage sub-device to the immunoassay sub-device for cleaning under the control of the controller;
the immune reagent supplying sub-device supplies immune reagents required for detecting the sample to be detected to the immunoassay sub-device under the control of the controller;
the second wash fluid storage sub-assembly is disposed inside or outside the sample analysis assembly.
9. The device of any one of claims 7 or 8, wherein the sample providing sub-device comprises a sampling needle, a drive assembly, and tubing.
10. A method of cleaning a sample analysis device, the method comprising:
controlling the immunoassay sub-device to detect a first background voltage value of the immunoassay sub-device when the sample to be detected does not exist;
determining a cleaning mode of the immunoassay sub-device according to the comparison between the first background voltage value and a preset background voltage threshold value and sending a corresponding cleaning instruction;
and responding to the cleaning instruction to correspondingly clean the immunoassay sub-device.
11. The method of claim 10, wherein the washing mode comprises a first washing mode and a second washing mode, the first washing mode is for washing the immunoassay sub-device with a first washing solution, and the second washing mode is for washing the immunoassay sub-device with a second washing solution.
12. The method of claim 11, wherein the first cleaning fluid is a regular cleaning fluid and the second cleaning fluid is a specialty cleaning fluid.
13. The method of claim 12, wherein the preset background voltage threshold M is 90 mv, 95 mv, 100 mv, 105 mv or 110 mv.
14. The method of claim 12, wherein the dedicated wash solution is a wash solution containing a hemolytic agent.
15. The method of claim 10, wherein said controlling said immunoassay sub-assembly to detect a first background voltage value of itself in the absence of a sample to be detected comprises:
controlling the immunoassay sub-device to detect a first background voltage value of the immunoassay sub-device after cleaning and when no sample to be detected exists;
the determining a cleaning mode of the immunoassay sub-device and sending a corresponding cleaning instruction according to the comparison of the first background voltage value and a preset background voltage threshold value comprises:
when the first background voltage value is smaller than the preset background voltage threshold value, the controller controls the immunoassay sub-device to detect a next sample to be detected, determines that a cleaning mode of the immunoassay sub-device after the next sample to be detected is a first cleaning mode, and sends a corresponding first cleaning instruction, and when the first background voltage value is larger than or equal to the preset background voltage threshold value, the controller determines that the cleaning mode of the immunoassay sub-device is a second cleaning mode, and sends a corresponding second cleaning instruction;
the corresponding washing of the immunoassay sub-assembly in response to the washing instruction comprises:
and responding to the first cleaning instruction to correspondingly clean the immunoassay sub-device after the immunoassay sub-device detects the next sample to be detected, or responding to the second cleaning instruction to correspondingly clean the immunoassay sub-device.
16. The method of claim 15, wherein the performing the corresponding cleaning of the immunoassay sub-assembly after the immunoassay sub-assembly has completed the detection of the next sample to be detected in response to the first cleaning instruction, or the performing the corresponding cleaning of the immunoassay sub-assembly in response to the second cleaning instruction comprises:
controlling the sample providing sub-device to provide the first washing solution in the first washing solution storage sub-device to the immunoassay sub-device for washing after the immunoassay sub-device detects the next sample to be detected in response to the first washing instruction,
alternatively, the sample providing sub-apparatus is controlled to provide the second washing solution in the second washing solution storage sub-apparatus to the immunoassay sub-apparatus for washing in response to the second washing instruction.
17. The method of claim 15, wherein the performing the corresponding cleaning of the immunoassay sub-assembly after the immunoassay sub-assembly has completed the detection of the next sample to be detected in response to the first cleaning instruction, or the performing the corresponding cleaning of the immunoassay sub-assembly in response to the second cleaning instruction comprises:
after the immunoassay sub-device detects the next sample to be detected in response to the first cleaning instruction, controlling the sample providing sub-device to provide the first cleaning solution in the first cleaning solution storage sub-device to the immunoassay sub-device for cleaning;
or, in response to the second washing instruction, controlling the second washing solution supply sub-device to supply the second washing solution in the second washing solution storage sub-device to the immunoassay sub-device for washing.
18. A sample analysis apparatus, comprising:
the immunoassay sub-device comprises a colorimetric pool, and a laser and a photoelectric receiver which are respectively arranged on the side edge of the colorimetric pool, wherein the colorimetric pool is used for containing soaking liquid when not in detection, and is used for discharging the soaking liquid and containing base liquid and a sample to be detected when in detection, the laser is used for emitting laser towards the colorimetric pool so that the photoelectric receiver obtains optical signals and converts the optical signals into electric signals, and the electric signals obtained by the photoelectric receiver when the colorimetric pool discharges the soaking liquid and only contains the base liquid are first background electric signals;
and the controller is used for acquiring the first background electric signal, comparing the first background electric signal with a preset background electric signal and sending out a corresponding cleaning instruction.
19. The sample analysis device of claim 18, further comprising a washing subsystem for performing a corresponding wash of the cuvette in response to the wash instruction, wherein:
when the first background electric signal is smaller than the preset background electric signal, the controller sends a first cleaning instruction to enable the cleaning subsystem to clean the colorimetric pool by adopting a first cleaning solution;
and when the first background electric signal is larger than or equal to the preset background electric signal, the controller sends a second cleaning instruction to enable the cleaning subsystem to clean the colorimetric pool by using a second cleaning solution, wherein the cleaning intensity of the second cleaning solution on a specific substance is larger than that of the first cleaning solution on the specific substance.
20. A sample analysis apparatus, comprising:
a container at least used for containing a base liquid and a sample to be detected;
the photoelectric detection assembly is used for detecting when the container only contains the base liquid to obtain a first base electric signal, and detecting when the container contains the base liquid and a sample to be detected to obtain a sample detection electric signal;
and the controller is used for sending a first instruction to clean or not clean the container in a first cleaning mode when the first background electric signal is smaller than a preset background electric signal threshold value, otherwise sending a second instruction to clean the container in a second cleaning mode, wherein the cleaning intensity of the specific substance in the second cleaning mode is greater than that in the first cleaning mode.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113311163A (en) * | 2020-02-26 | 2021-08-27 | 深圳迈瑞生物医疗电子股份有限公司 | Cleaning method of detection pool |
| CN114002424A (en) * | 2021-12-31 | 2022-02-01 | 深圳市帝迈生物技术有限公司 | Sample analyzer and detection method thereof |
| CN114002423A (en) * | 2021-12-31 | 2022-02-01 | 深圳市帝迈生物技术有限公司 | Sample analyzer and detection method thereof |
| CN114113566A (en) * | 2020-08-28 | 2022-03-01 | 深圳市帝迈生物技术有限公司 | Method for detecting clogging of sampling needle, blood analyzer, and computer storage medium |
| CN114791502A (en) * | 2022-06-13 | 2022-07-26 | 深圳市帝迈生物技术有限公司 | Sample detection method and sample analyzer |
| CN114871210A (en) * | 2022-07-08 | 2022-08-09 | 深圳市帝迈生物技术有限公司 | Cleaning method of sample analyzer, sample analyzer and control device thereof |
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| CN114308849B (en) * | 2020-09-29 | 2023-04-18 | 深圳市帝迈生物技术有限公司 | Method for avoiding liquid level error detection and sample analyzer |
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008107447A (en) * | 2006-10-24 | 2008-05-08 | Kyocera Mita Corp | Image forming apparatus |
| CN102912453A (en) * | 2011-08-06 | 2013-02-06 | 郑修余 | Eiderdown cleaning system |
| CN104437099A (en) * | 2014-12-19 | 2015-03-25 | 山东中保康医疗器具有限公司 | Disposable leukocyte-depleting filter membrane material cleaning device and cleaning water detection method |
| CN105627518A (en) * | 2016-01-20 | 2016-06-01 | 广东美的制冷设备有限公司 | Filth blockage detecting method and device of air conditioner |
| JP2017038926A (en) * | 2015-08-17 | 2017-02-23 | アイロボット コーポレイション | Autonomous floor cleaning with removable pad |
| CN107643393A (en) * | 2016-07-21 | 2018-01-30 | 深圳迈瑞生物医疗电子股份有限公司 | The purposes of sample analyser and its cleaning method, liquid containing hemolytic agent composition |
| CN108254584A (en) * | 2016-12-28 | 2018-07-06 | 希森美康株式会社 | Analysis method and analytical equipment |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1346058A (en) * | 2000-09-22 | 2002-04-24 | 迪亚西斯公司 | Apparatus for automatic treating liquid sample |
| JP2004356356A (en) * | 2003-05-29 | 2004-12-16 | Oki Electric Ind Co Ltd | Method for judging completion of cleaning and cleaning apparatus |
| CN201302575Y (en) * | 2008-10-07 | 2009-09-02 | 丁卫东 | Cleaning device with clogging alarm apparatus |
| CN106894197A (en) * | 2015-12-21 | 2017-06-27 | 北京奇虎科技有限公司 | object cleaning method, device and washing machine |
| CN106111593A (en) * | 2016-07-14 | 2016-11-16 | 广东美的厨房电器制造有限公司 | Control the method and apparatus carrying out Fouling Cleaning |
| CN107643410B (en) * | 2016-07-21 | 2021-04-02 | 深圳迈瑞生物医疗电子股份有限公司 | Sample analyzer and cleaning control method for sample analyzer |
-
2019
- 2019-07-23 CN CN201910667216.6A patent/CN110749730B/en active Active
- 2019-07-23 WO PCT/CN2019/097319 patent/WO2020020169A1/en active Application Filing
- 2019-07-23 CN CN201910667208.1A patent/CN110749729B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008107447A (en) * | 2006-10-24 | 2008-05-08 | Kyocera Mita Corp | Image forming apparatus |
| CN102912453A (en) * | 2011-08-06 | 2013-02-06 | 郑修余 | Eiderdown cleaning system |
| CN104437099A (en) * | 2014-12-19 | 2015-03-25 | 山东中保康医疗器具有限公司 | Disposable leukocyte-depleting filter membrane material cleaning device and cleaning water detection method |
| JP2017038926A (en) * | 2015-08-17 | 2017-02-23 | アイロボット コーポレイション | Autonomous floor cleaning with removable pad |
| CN105627518A (en) * | 2016-01-20 | 2016-06-01 | 广东美的制冷设备有限公司 | Filth blockage detecting method and device of air conditioner |
| CN107643393A (en) * | 2016-07-21 | 2018-01-30 | 深圳迈瑞生物医疗电子股份有限公司 | The purposes of sample analyser and its cleaning method, liquid containing hemolytic agent composition |
| CN108254584A (en) * | 2016-12-28 | 2018-07-06 | 希森美康株式会社 | Analysis method and analytical equipment |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113311163A (en) * | 2020-02-26 | 2021-08-27 | 深圳迈瑞生物医疗电子股份有限公司 | Cleaning method of detection pool |
| CN113311163B (en) * | 2020-02-26 | 2024-04-12 | 深圳迈瑞生物医疗电子股份有限公司 | Cleaning method of detection pool |
| CN114113566A (en) * | 2020-08-28 | 2022-03-01 | 深圳市帝迈生物技术有限公司 | Method for detecting clogging of sampling needle, blood analyzer, and computer storage medium |
| CN115524504A (en) * | 2021-06-25 | 2022-12-27 | 深圳市帝迈生物技术有限公司 | Sample analysis device, cleaning method thereof and computer-readable storage medium |
| CN114002424A (en) * | 2021-12-31 | 2022-02-01 | 深圳市帝迈生物技术有限公司 | Sample analyzer and detection method thereof |
| CN114002423A (en) * | 2021-12-31 | 2022-02-01 | 深圳市帝迈生物技术有限公司 | Sample analyzer and detection method thereof |
| CN114791502A (en) * | 2022-06-13 | 2022-07-26 | 深圳市帝迈生物技术有限公司 | Sample detection method and sample analyzer |
| CN114791502B (en) * | 2022-06-13 | 2022-10-28 | 深圳市帝迈生物技术有限公司 | Sample detection method and sample analyzer |
| CN114871210A (en) * | 2022-07-08 | 2022-08-09 | 深圳市帝迈生物技术有限公司 | Cleaning method of sample analyzer, sample analyzer and control device thereof |
| CN114871210B (en) * | 2022-07-08 | 2022-10-28 | 深圳市帝迈生物技术有限公司 | Cleaning method of sample analyzer, sample analyzer and control device thereof |
Also Published As
| Publication number | Publication date |
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| CN110749730B (en) | 2023-09-15 |
| WO2020020169A1 (en) | 2020-01-30 |
| CN110749729B (en) | 2023-09-15 |
| CN110749729A (en) | 2020-02-04 |
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