CN114618853A - Cleaning method of sample analyzer and sample analyzer - Google Patents
Cleaning method of sample analyzer and sample analyzer Download PDFInfo
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- CN114618853A CN114618853A CN202210509976.6A CN202210509976A CN114618853A CN 114618853 A CN114618853 A CN 114618853A CN 202210509976 A CN202210509976 A CN 202210509976A CN 114618853 A CN114618853 A CN 114618853A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B13/00—Accessories or details of general applicability for machines or apparatus for cleaning
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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Abstract
The application provides a cleaning method of a sample analyzer and the sample analyzer. The cleaning method of the sample analyzer is applied to the sample analyzer, the sample analyzer comprises a detection unit and a cleaning unit connected with the detection unit, and specifically, the cleaning method comprises the following steps: adding a sample to be detected into a detection unit; detecting a preset item of a sample to be detected in the detection unit to obtain a detection result; judging whether the detection result is in a preset range or not; if yes, cleaning the detection unit through the cleaning unit in a first cleaning mode; and if not, cleaning the detection unit by the cleaning unit in a second cleaning mode. According to the cleaning method of the sample analyzer, the corresponding cleaning mode can be selected according to the detection result of the sample, and the accuracy of detecting the next sample after the high-value sample is tested is improved.
Description
Technical Field
The application relates to the field of medical equipment, in particular to a cleaning method of a sample analyzer and the sample analyzer.
Background
And in the normal detection process of the sample analyzer, the sample to be detected is sent into the detection unit for detection, the detection part is cleaned after the detection is finished, and then the next detection sample liquid is prepared.
However, there is an upper limit to the cleaning capability of the sample analyzer for the detection unit, and after the detection unit tests a high-value sample, the accuracy of the next sample detection may be affected due to poor cleaning effect.
Disclosure of Invention
The application provides a cleaning method of a sample analyzer and the sample analyzer, which are used for solving the technical problem that after a detection unit tests a high-value sample in the prior art, the accuracy of next sample detection can be influenced due to poor cleaning effect.
In order to solve the technical problem, the application adopts a technical scheme that: provided is a cleaning method of a sample analyzer, the cleaning method being applied to the sample analyzer, the sample analyzer including a detection unit and a cleaning unit connected to the detection unit, specifically, the cleaning method includes: adding a sample to be detected into a detection unit; detecting a preset item of a sample to be detected in the detection unit to obtain a detection result; judging whether the detection result is within a preset range; if yes, cleaning the detection unit through the cleaning unit in a first cleaning mode; and if not, cleaning the detection unit by the cleaning unit in a second cleaning mode.
Further, the second washing mode has a washing time or a washing number greater than that of the first washing mode.
Further, after the step of cleaning the detection unit in the second cleaning mode by the cleaning unit, the cleaning method further includes: performing blank test on the cleaned detection unit to obtain a blank test result; judging whether the blank test result meets a preset condition or not; and returning to the step of cleaning the detection unit in the second cleaning mode through the cleaning unit when the blank test result is confirmed not to meet the preset condition.
Further, the sample analyzer further comprises a sample adding unit, and the cleaning method further comprises the following steps: and when the blank test result meets the preset condition, adding a new sample to be tested into the detection unit through the sample adding unit.
Further, the step of performing a blank test on the cleaned detection unit to obtain a blank test result includes: and detecting the preset items of the cleaned detection unit again to obtain a blank test result.
Further, the preset items include: at least one of a cell count, a cell classification, and an immunoassay.
Further, the detection unit comprises a reaction pool and a counting pool, and the sample to be detected is added into the detection unit, wherein the step of adding the sample and the reagent into the reaction pool to obtain the sample to be detected; the method for detecting the preset items of the sample to be detected in the detection unit to obtain the detection result comprises the following steps: and (3) enabling the sample to be detected in the reaction tank to enter a counting tank, and counting the cells of the sample to be detected by using the counting tank to obtain the number of the cells.
Further, be equipped with the micropore piece in the counting cell, be provided with the micropore on the micropore piece, make the sample that awaits measuring enter into the counting cell in the reaction tank, utilize the counting cell to carry out cell count to the sample that awaits measuring to obtain the quantity of cell, include: and enabling the sample to be detected in the reaction tank to pass through the micropores so as to count the cells and obtain the number of the cells.
Further, the sample analyzer further includes a sample adding unit, and the step of adding the sample and the reagent to the reaction cell includes: and adding the sample and the reagent into the reaction cell through the sample adding unit.
In order to solve the above technical problem, another technical solution adopted by the present application is: there is provided a sample analyzer comprising: the device comprises a detection unit, a cleaning unit and a control unit, wherein the detection unit is used for detecting a preset item of a sample to be detected; the cleaning unit is connected with the detection unit and is used for cleaning the detection unit; the control unit is respectively connected with the detection unit and the cleaning unit, and the control unit is used for realizing the cleaning method of the sample analyzer in any one of the embodiments.
The beneficial effect of this application is: the cleaning method of the sample analyzer comprises the following steps: adding a sample to be detected into a detection unit; detecting a preset item of a sample to be detected in the detection unit to obtain a detection result; judging whether the detection result is within a preset range; if yes, cleaning the detection unit through the cleaning unit in a first cleaning mode; and if not, cleaning the detection unit by the cleaning unit in a second cleaning mode. According to the cleaning method of the sample analyzer, the corresponding cleaning mode can be intelligently selected according to the detection result of the sample to be detected, the cleaning effect of the sample analyzer is enhanced, and the accuracy of detecting the next sample after the high-value sample is tested is improved.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed to be used in the description of the embodiments are briefly introduced below, it is obvious that the drawings in the following description are only some embodiments of the present application, and other drawings can be obtained by those skilled in the art without inventive efforts, wherein:
FIG. 1 is a schematic block diagram of one embodiment of a sample analyzer provided herein;
FIG. 2 is a schematic flow chart diagram of one embodiment of a method for cleaning a sample analyzer provided herein;
fig. 3 is a schematic flow diagram of another embodiment of a method for cleaning a sample analyzer provided herein.
Detailed Description
The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
It should be noted that if directional indications (such as up, down, left, right, front, and back … …) are referred to in the embodiments of the present application, the directional indications are only used to explain the relative positional relationship between the components, the movement situation, and the like in a specific posture (as shown in the drawings), and if the specific posture is changed, the directional indications are changed accordingly.
In addition, if there is a description of "first", "second", etc. in the embodiments of the present application, the description of "first", "second", etc. is for descriptive purposes only and is not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one of the feature. In addition, technical solutions between various embodiments may be combined with each other, but must be realized by a person skilled in the art, and when the technical solutions are contradictory or cannot be realized, such a combination should not be considered to exist, and is not within the protection scope of the present application.
The application provides a cleaning method of a sample analyzer and the sample analyzer, the cleaning method can intelligently select a corresponding cleaning mode according to a detection result of a detection unit on a sample to be detected, the cleaning effect of the sample analyzer is improved, the influence on the next detection result of the sample is reduced, and therefore the reliability of the sample analyzer is improved.
Referring to fig. 1, fig. 1 is a schematic structural diagram of an embodiment of a sample analyzer 10 provided in the present application, including: a cleaning unit 11 and a detection unit 12.
The detection unit 12 is used for detecting a sample to be detected, and the cleaning unit 11 is used for cleaning the detection unit 12. When the sample analyzer 10 detects a sample to be tested, the sample to be tested may be added into the detection unit 12, and then the sample to be tested is tested and analyzed through the detection unit 12. The sample to be detected may be a blood sample, and the application is described by taking the sample to be detected as the blood sample. It is understood that in other embodiments, the sample to be tested may be saliva, tears, or other body fluids.
Alternatively, the detecting unit 12 may be used to detect a predetermined item of the sample, for example, the detecting unit 12 may be used to perform cell counting, cell classification, or immunoassay on the sample to be detected.
Further, as shown in fig. 1, the sample analyzer 10 may further include a sample adding unit 13, and the sample adding unit 13 is configured to add a sample to the detecting unit 12.
Based on the sample analyzer 10, the present application further provides a method for cleaning a sample analyzer, please refer to fig. 2, fig. 2 is a schematic flowchart of an embodiment of the method for cleaning a sample analyzer provided in the present application, and specifically, the method for cleaning a sample analyzer includes:
s11: adding the sample to be detected into the detection unit.
The sample to be tested is added to the testing unit 12 to be tested by the testing unit 12. Specifically, the sample analyzer 10 may include a sample adding unit 13, and the sample analyzer 10 may add the sample to be detected to the detecting unit 12 through the sample adding unit 13, so as to implement automatic sample adding of the sample analyzer.
Further, as shown in fig. 1, the sample adding unit 13 may include a sampling device (not shown) for sucking a sample and adding the sample to the detecting unit 12, and a reagent adding device 131 for adding a reagent to the detecting unit 12, where the sample and the reagent are sufficiently reacted at the detecting unit 12 to obtain a sample to be detected.
Further, as shown in fig. 1, the detecting unit 12 may include a reaction cell (not labeled), through which the sample analyzer 10 prepares the sample to be detected, specifically, the sample analyzer 10 adds the sample to the reaction cell through a sampling device, adds a reagent to the reaction cell through a reagent adding device 131, and the sample and the reagent are mixed and reacted in the reaction cell sufficiently to obtain the sample to be detected. By the method, the preparation of the sample to be detected is facilitated.
In other embodiments, the sample analyzer 10 can directly add the prepared sample to be tested to the detecting unit 12 through the adding unit 13. In other embodiments, the sample to be tested can be added to the detecting unit 12 by manual sample adding.
S12: and detecting preset items of the sample to be detected in the detection unit to obtain a detection result.
After the sample to be detected is added into the detection unit 12, the sample analyzer 10 performs the detection of the preset item on the sample to be detected in the detection unit 12 to obtain the corresponding detection result.
Specifically, the preset items may include: at least one of a cell count, a cell classification, and an immunoassay. The cell count may include, among others, a white blood cell count, a red blood cell count, or a platelet count.
Optionally, when the preset item is cell count, the detecting unit 12 further includes a counting cell (not shown) for counting cells of the sample to be tested in the reaction cell. Specifically, when the cell count is performed on the sample to be detected, the sample to be detected in the reaction tank can enter the counting tank through the pressure source, and the cell count is performed on the sample to be detected by using the counting tank, so as to obtain the number of cells in the sample to be detected.
For example, in one embodiment, the predetermined item is a white blood cell count, and the sample analyzer 10 can perform the white blood cell count on the sample to be tested by an impedance measurement method. Specifically, a microporous sheet (not shown) is disposed in the counting cell, and the microporous sheet is provided with micropores, so that when a sample in the detection unit 12 is detected, the sample to be detected in the reaction cell can pass through the micropores by the pressure source 2 in fig. 1 to count leukocytes of the sample to be detected, thereby obtaining the total leukocyte number of the sample to be detected or the number of leukocytes passing through the micropores in unit time, and thus obtaining a detection result.
In other embodiments, the cells may also be counted by other detection means, such as flow-based fluorescence detection. Both impedance detection and flow-through fluorescence detection are within the understanding of those skilled in the art and are not specifically described herein.
It is understood that, when the sample to be tested is tested for other items, the testing unit 12 includes testing components corresponding to the testing items, which are not listed here.
S13: and judging whether the detection result is in a preset range.
And after the detection result of the sample to be detected is obtained, judging whether the detection result is in a preset range. The preset range may be smaller than a set threshold, that is, when the detection result is smaller than the set threshold, the detection result may be considered to be in the preset range, and when the detection result is not smaller than the set threshold, the detection result may be considered to be out of the preset range.
For example, when the total number of white blood cells is the detection result, the detection result may be considered to be in a preset range when the total number of white blood cells is less than a set threshold, and the detection result may be considered to be out of the preset range when the total number of white blood cells is not less than (i.e., greater than or equal to) the threshold.
S14: if yes, the detection unit is cleaned through the cleaning unit in a first cleaning mode.
When the detection result is determined to be within the preset range, the sample to be detected is considered to be a non-high value sample, and the cleaning unit 11 may clean the detection unit 12 in a first cleaning mode, where the first cleaning mode may be a normal cleaning mode. For example, the number of times of cleaning in the normal cleaning mode is 1 or 2.
For example, when the detection unit 12 includes a reaction cell and a counting cell, and the detection result is within a preset range, the reaction cell and the counting cell may be cleaned in a first cleaning mode by the cleaning unit 11.
S15: if not, the detection unit is cleaned through the cleaning unit in a second cleaning mode.
When the detection result is determined not to be within the preset range, the sample to be detected is considered as a high-value sample, and the cleaning unit 11 may clean the detection unit 12 in the second cleaning mode. The second cleaning mode may be a reinforced cleaning mode, and specifically, the cleaning time or the cleaning frequency of the second cleaning mode is greater than that of the first cleaning mode, so as to reinforce the cleaning of the detection unit 12. For example, the number of times of cleaning in the second cleaning mode is 2, and the number of times of cleaning in the first cleaning mode is 1. Alternatively, the cleaning time in the second cleaning mode is 2 minutes, and the cleaning time in the first cleaning mode is 1 minute. That is, the cleaning intensity of the second cleaning mode is higher than that of the first cleaning mode.
For example, when the detection unit 12 includes a reaction cell and a counting cell, and the detection result is not within the preset range, the reaction cell and the counting cell may be intensively cleaned by the cleaning unit 11 in the second cleaning mode, so as to improve the detection accuracy of the next sample after the high-value sample is tested.
In the above embodiment, the sample analyzer can intelligently select the corresponding cleaning mode according to the detection result of the sample to be detected, so that the cleaning effect of the sample analyzer can be improved, and the accuracy of detection on the next sample after the high-value sample is tested is improved.
Referring to fig. 3, fig. 3 is a schematic flow chart of another embodiment of a cleaning method of a sample analyzer, in the embodiment, the cleaning method includes:
s21: adding the sample to be detected into the detection unit.
Step S21 is the same as step S11, and is not repeated here.
S22: and detecting preset items of the sample to be detected in the detection unit to obtain a detection result.
Step S22 is the same as step S12, and is not repeated here.
S23: and judging whether the detection result is in a preset range.
Step S23 is the same as step S13, and is not repeated here.
S24: if not, the detection unit is cleaned through the cleaning unit in a second cleaning mode.
Step S24 is the same as step S15, and is not repeated here.
S25: and carrying out blank test on the cleaned detection unit to obtain a blank test result.
After the detecting unit 12 is cleaned in the second cleaning mode, a blank test is performed on the cleaned detecting unit 12, that is, the background value of the detecting unit 12 is tested to obtain a blank test result.
Specifically, before the next sample application, the cleaned detection unit 12 may be subjected to the detection of the preset item again to obtain the blank test result.
For example, when the preset item is a white blood cell count, after the detecting unit 12 is cleaned in the second cleaning mode, the white blood cell count is performed on the cleaned detecting unit 12 to obtain a blank test result.
S26: and judging whether the blank test result meets a preset condition or not.
And after the blank test result is obtained, judging whether the blank test result meets a preset condition. The preset condition may be that the blank test result is smaller than a preset background value. When the blank test result is less than the preset background value, it can be determined that the blank test result satisfies the preset condition, and when the blank test result is not less than the preset background value (i.e., greater than or equal to the preset background value), it can be determined that the blank test result does not satisfy the preset condition.
By performing a blank test on the cleaned detection unit 12, it can be confirmed whether the detection unit 12 is cleaned to determine whether the detection unit 12 needs to be cleaned again.
S27: and returning to the step of cleaning the detection unit in the second cleaning mode through the cleaning unit when the blank test result is confirmed not to meet the preset condition.
When it is determined that the blank test result does not satisfy the preset condition, the detecting unit 12 is not cleaned, and at this time, the step S24 is returned, and the cleaning unit 11 is controlled to clean the detecting unit 12 in the second cleaning mode again until the blank test result satisfies the preset condition, so as to improve the cleaning effect of the detecting unit 12 and improve the accuracy of the detecting unit 12 in detecting the next sample to be tested.
S28: and when the blank test result meets the preset condition, adding a new sample to be tested into the detection unit through the sample adding unit.
When it is determined that the blank test result satisfies the preset condition, it may be determined that the detection unit 12 is cleaned, and therefore, the next sample to be detected may be detected, at this time, the sample analyzer 10 may control the sample adding unit 13 to add a new sample to be detected into the detection unit 12, and use the new sample to be detected as the sample to be detected, and the detection unit 12 may detect the sample to be detected again.
The cleaning method of the sample analyzer of the embodiment can intelligently select the cleaning mode according to the detection result of the sample to be tested, when the sample to be tested is a non-high-value sample, the normal cleaning mode is adopted, and when the sample to be tested is a high-value sample, the mode of strengthening cleaning can be adopted.
The present application further provides a sample analyzer, comprising at least: the device comprises a detection unit, a cleaning unit and a control unit, wherein the control unit is connected with the detection unit and the cleaning unit, and is used for realizing the cleaning method of the sample analyzer in any one of the embodiments. Please refer to the description of any of the above embodiments for a method for cleaning a sample analyzer and a specific structure of the sample analyzer, which are not described herein again.
The above embodiments are merely examples and are not intended to limit the scope of the present disclosure, and all modifications, equivalents, and flow charts using the contents of the specification and drawings of the present disclosure, which are directly or indirectly applied to other related technical fields, are included in the scope of the present disclosure.
Claims (10)
1. A method of cleaning a sample analyzer, the method being applied to a sample analyzer including a detection unit and a cleaning unit connected to the detection unit, the method comprising:
adding a sample to be detected to the detection unit;
detecting preset items of the sample to be detected in the detection unit to obtain a detection result;
judging whether the detection result is in a preset range or not;
if yes, cleaning the detection unit through the cleaning unit in a first cleaning mode;
and if not, cleaning the detection unit by the cleaning unit in a second cleaning mode.
2. The washing method according to claim 1, wherein the second washing mode is more washing time or washing number than the first washing mode.
3. The washing method according to claim 2, wherein after the step of washing the detection unit in the second washing mode by the washing unit, the washing method further comprises:
performing blank test on the cleaned detection unit to obtain a blank test result;
judging whether the blank test result meets a preset condition or not;
and returning to the step of cleaning the detection unit by the cleaning unit in a second cleaning mode when the blank test result is confirmed not to meet the preset condition.
4. The washing method of claim 3, wherein the sample analyzer further comprises a sample application unit, the washing method further comprising:
and when the blank test result is confirmed to meet the preset condition, adding a new sample to be tested into the detection unit through the sample adding unit.
5. The cleaning method according to claim 3, wherein the step of performing a blank test on the cleaned detection unit to obtain a blank test result comprises:
and detecting the preset item again for the cleaned detection unit to obtain the blank test result.
6. The cleaning method according to any one of claims 1 to 5, wherein the preset items include: at least one of a cell count, a cell classification, and an immunoassay.
7. The washing method as claimed in claim 1, wherein the detection unit comprises a reaction cell and a counting cell;
adding a sample to be detected into the detection unit, including adding the sample and a reagent into the reaction tank to obtain the sample to be detected;
the detecting of preset items is carried out to the sample to be detected in the detecting unit to obtain a detecting result, and the detecting method comprises the following steps:
and enabling a sample to be detected in the reaction tank to enter the counting tank, and counting the cells of the sample to be detected by using the counting tank to obtain the number of the cells.
8. The cleaning method according to claim 7, wherein a microporous sheet is disposed in the counting chamber, and micropores are disposed on the microporous sheet, and the step of allowing the sample to be tested in the reaction chamber to enter the counting chamber and counting the cells of the sample to be tested by using the counting chamber to obtain the number of the cells comprises: and enabling the sample to be detected in the reaction pool to pass through the micropores so as to count the cells and obtain the number of the cells.
9. The washing method according to claim 7, wherein the sample analyzer further comprises a sample adding unit, and the step of adding the sample and the reagent to the reaction cell comprises:
and adding the sample and the reagent into the reaction cell through the sample adding unit.
10. A sample analyzer, comprising:
the detection unit is used for detecting a preset item of a sample to be detected;
the cleaning unit is connected with the detection unit and is used for cleaning the detection unit;
a control unit connected to the detection unit and the washing unit, respectively, and adapted to implement a washing method of the sample analyzer according to any one of claims 1 to 9.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202210509976.6A CN114618853A (en) | 2022-05-11 | 2022-05-11 | Cleaning method of sample analyzer and sample analyzer |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202210509976.6A CN114618853A (en) | 2022-05-11 | 2022-05-11 | Cleaning method of sample analyzer and sample analyzer |
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