CN110664906B - 一种具有降血糖功能的保健食品的制备方法 - Google Patents
一种具有降血糖功能的保健食品的制备方法 Download PDFInfo
- Publication number
- CN110664906B CN110664906B CN201910901417.8A CN201910901417A CN110664906B CN 110664906 B CN110664906 B CN 110664906B CN 201910901417 A CN201910901417 A CN 201910901417A CN 110664906 B CN110664906 B CN 110664906B
- Authority
- CN
- China
- Prior art keywords
- parts
- ethanol
- health food
- mixing
- blood sugar
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 210000004369 blood Anatomy 0.000 title claims abstract description 67
- 239000008280 blood Substances 0.000 title claims abstract description 67
- 235000013402 health food Nutrition 0.000 title claims abstract description 54
- 230000001603 reducing effect Effects 0.000 title claims abstract description 28
- 238000002360 preparation method Methods 0.000 title claims abstract description 23
- 235000001498 Salvia hispanica Nutrition 0.000 claims abstract description 28
- 235000012377 Salvia columbariae var. columbariae Nutrition 0.000 claims abstract description 27
- 235000014167 chia Nutrition 0.000 claims abstract description 27
- 235000007516 Chrysanthemum Nutrition 0.000 claims abstract description 24
- 241000205585 Aquilegia canadensis Species 0.000 claims abstract description 23
- 241000222336 Ganoderma Species 0.000 claims abstract description 23
- 240000000249 Morus alba Species 0.000 claims abstract description 23
- 235000008708 Morus alba Nutrition 0.000 claims abstract description 23
- DLRVVLDZNNYCBX-RTPHMHGBSA-N isomaltose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)C(O)O1 DLRVVLDZNNYCBX-RTPHMHGBSA-N 0.000 claims abstract description 21
- 239000002994 raw material Substances 0.000 claims abstract description 21
- 235000019225 fermented tea Nutrition 0.000 claims abstract description 19
- 235000017784 Mespilus germanica Nutrition 0.000 claims abstract description 15
- 244000182216 Mimusops elengi Species 0.000 claims abstract description 15
- 235000000560 Mimusops elengi Nutrition 0.000 claims abstract description 15
- 235000007837 Vangueria infausta Nutrition 0.000 claims abstract description 15
- 241000131458 Elsholtzia Species 0.000 claims abstract description 11
- 241000208688 Eucommia Species 0.000 claims abstract description 7
- 244000061520 Angelica archangelica Species 0.000 claims abstract description 6
- 235000001287 Guettarda speciosa Nutrition 0.000 claims abstract description 6
- 241000208966 Polygala Species 0.000 claims abstract description 5
- 235000013305 food Nutrition 0.000 claims abstract description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 130
- 238000002156 mixing Methods 0.000 claims description 46
- 239000000706 filtrate Substances 0.000 claims description 32
- 244000269722 Thea sinensis Species 0.000 claims description 27
- 238000001914 filtration Methods 0.000 claims description 24
- 239000000203 mixture Substances 0.000 claims description 22
- 239000012530 fluid Substances 0.000 claims description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 19
- 235000006468 Thea sinensis Nutrition 0.000 claims description 18
- 235000020279 black tea Nutrition 0.000 claims description 18
- 239000008187 granular material Substances 0.000 claims description 15
- 239000000463 material Substances 0.000 claims description 14
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 8
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 8
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 8
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 8
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 8
- 238000003756 stirring Methods 0.000 claims description 8
- 241000723353 Chrysanthemum Species 0.000 claims description 5
- 239000002552 dosage form Substances 0.000 claims description 5
- 241000717679 Mosla Species 0.000 claims description 4
- 239000002671 adjuvant Substances 0.000 claims description 4
- 230000002218 hypoglycaemic effect Effects 0.000 claims description 4
- 235000019359 magnesium stearate Nutrition 0.000 claims description 4
- 238000009472 formulation Methods 0.000 claims description 3
- 235000009569 green tea Nutrition 0.000 claims description 2
- 238000010992 reflux Methods 0.000 claims description 2
- 244000292604 Salvia columbariae Species 0.000 claims 4
- 230000000694 effects Effects 0.000 abstract description 31
- 240000005481 Salvia hispanica Species 0.000 abstract description 24
- 244000189548 Chrysanthemum x morifolium Species 0.000 abstract description 19
- 230000003647 oxidation Effects 0.000 abstract description 5
- 238000007254 oxidation reaction Methods 0.000 abstract description 5
- 208000031226 Hyperlipidaemia Diseases 0.000 abstract description 4
- 206010020772 Hypertension Diseases 0.000 abstract description 4
- 230000036039 immunity Effects 0.000 abstract description 3
- 238000012545 processing Methods 0.000 abstract description 2
- 230000003796 beauty Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 19
- 238000000034 method Methods 0.000 description 18
- 210000004185 liver Anatomy 0.000 description 14
- 244000237330 gutta percha tree Species 0.000 description 12
- 241000382455 Angelica sinensis Species 0.000 description 11
- 241001080798 Polygala tenuifolia Species 0.000 description 11
- 229940079593 drug Drugs 0.000 description 11
- 210000003734 kidney Anatomy 0.000 description 11
- 238000012360 testing method Methods 0.000 description 11
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 9
- 244000241838 Lycium barbarum Species 0.000 description 9
- 235000015459 Lycium barbarum Nutrition 0.000 description 9
- 235000015468 Lycium chinense Nutrition 0.000 description 9
- 201000010099 disease Diseases 0.000 description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 9
- 239000008103 glucose Substances 0.000 description 9
- 210000004072 lung Anatomy 0.000 description 9
- 239000000047 product Substances 0.000 description 9
- 235000013399 edible fruits Nutrition 0.000 description 8
- 208000024891 symptom Diseases 0.000 description 8
- 235000019197 fats Nutrition 0.000 description 7
- 230000036541 health Effects 0.000 description 7
- 235000013616 tea Nutrition 0.000 description 7
- 238000005303 weighing Methods 0.000 description 7
- 241000628997 Flos Species 0.000 description 6
- 230000001105 regulatory effect Effects 0.000 description 6
- 210000003491 skin Anatomy 0.000 description 6
- 206010030113 Oedema Diseases 0.000 description 5
- 230000032683 aging Effects 0.000 description 5
- 230000017531 blood circulation Effects 0.000 description 5
- 230000036772 blood pressure Effects 0.000 description 5
- 235000009508 confectionery Nutrition 0.000 description 5
- 238000007796 conventional method Methods 0.000 description 5
- 210000002216 heart Anatomy 0.000 description 5
- 230000006872 improvement Effects 0.000 description 5
- 230000004060 metabolic process Effects 0.000 description 5
- 230000009467 reduction Effects 0.000 description 5
- 210000002784 stomach Anatomy 0.000 description 5
- 238000003860 storage Methods 0.000 description 5
- 231100000331 toxic Toxicity 0.000 description 5
- 230000002588 toxic effect Effects 0.000 description 5
- 238000009423 ventilation Methods 0.000 description 5
- 240000008397 Ganoderma lucidum Species 0.000 description 4
- 235000001637 Ganoderma lucidum Nutrition 0.000 description 4
- 229920002774 Maltodextrin Polymers 0.000 description 4
- 239000005913 Maltodextrin Substances 0.000 description 4
- 206010028980 Neoplasm Diseases 0.000 description 4
- 208000012886 Vertigo Diseases 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 4
- 239000003963 antioxidant agent Substances 0.000 description 4
- 235000006708 antioxidants Nutrition 0.000 description 4
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 4
- 230000007812 deficiency Effects 0.000 description 4
- 230000029087 digestion Effects 0.000 description 4
- 238000001035 drying Methods 0.000 description 4
- 230000004438 eyesight Effects 0.000 description 4
- 201000001421 hyperglycemia Diseases 0.000 description 4
- 230000001976 improved effect Effects 0.000 description 4
- IYRMWMYZSQPJKC-UHFFFAOYSA-N kaempferol Chemical compound C1=CC(O)=CC=C1C1=C(O)C(=O)C2=C(O)C=C(O)C=C2O1 IYRMWMYZSQPJKC-UHFFFAOYSA-N 0.000 description 4
- 229940035034 maltodextrin Drugs 0.000 description 4
- 230000000291 postprandial effect Effects 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 4
- 238000011160 research Methods 0.000 description 4
- 239000007779 soft material Substances 0.000 description 4
- 210000000952 spleen Anatomy 0.000 description 4
- 238000005728 strengthening Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- QAIPRVGONGVQAS-DUXPYHPUSA-N trans-caffeic acid Chemical compound OC(=O)\C=C\C1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-DUXPYHPUSA-N 0.000 description 4
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 4
- 231100000889 vertigo Toxicity 0.000 description 4
- 208000004998 Abdominal Pain Diseases 0.000 description 3
- 206010011224 Cough Diseases 0.000 description 3
- 206010012735 Diarrhoea Diseases 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 3
- 208000002193 Pain Diseases 0.000 description 3
- 208000004880 Polyuria Diseases 0.000 description 3
- 206010037660 Pyrexia Diseases 0.000 description 3
- 206010042674 Swelling Diseases 0.000 description 3
- 206010003549 asthenia Diseases 0.000 description 3
- 210000004204 blood vessel Anatomy 0.000 description 3
- 239000002775 capsule Substances 0.000 description 3
- 206010012601 diabetes mellitus Diseases 0.000 description 3
- 235000005911 diet Nutrition 0.000 description 3
- 230000037213 diet Effects 0.000 description 3
- 230000035619 diuresis Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 230000001939 inductive effect Effects 0.000 description 3
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 description 3
- 230000008961 swelling Effects 0.000 description 3
- 208000011580 syndromic disease Diseases 0.000 description 3
- 230000035922 thirst Effects 0.000 description 3
- 230000010415 tropism Effects 0.000 description 3
- ACEAELOMUCBPJP-UHFFFAOYSA-N (E)-3,4,5-trihydroxycinnamic acid Natural products OC(=O)C=CC1=CC(O)=C(O)C(O)=C1 ACEAELOMUCBPJP-UHFFFAOYSA-N 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- CWVRJTMFETXNAD-FWCWNIRPSA-N 3-O-Caffeoylquinic acid Natural products O[C@H]1[C@@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-FWCWNIRPSA-N 0.000 description 2
- 201000000736 Amenorrhea Diseases 0.000 description 2
- 206010001928 Amenorrhoea Diseases 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Natural products OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 206010063659 Aversion Diseases 0.000 description 2
- PZIRUHCJZBGLDY-UHFFFAOYSA-N Caffeoylquinic acid Natural products CC(CCC(=O)C(C)C1C(=O)CC2C3CC(O)C4CC(O)CCC4(C)C3CCC12C)C(=O)O PZIRUHCJZBGLDY-UHFFFAOYSA-N 0.000 description 2
- 206010007247 Carbuncle Diseases 0.000 description 2
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 2
- 206010010774 Constipation Diseases 0.000 description 2
- UBSCDKPKWHYZNX-UHFFFAOYSA-N Demethoxycapillarisin Natural products C1=CC(O)=CC=C1OC1=CC(=O)C2=C(O)C=C(O)C=C2O1 UBSCDKPKWHYZNX-UHFFFAOYSA-N 0.000 description 2
- 208000005171 Dysmenorrhea Diseases 0.000 description 2
- 206010013935 Dysmenorrhoea Diseases 0.000 description 2
- 208000015220 Febrile disease Diseases 0.000 description 2
- 206010019233 Headaches Diseases 0.000 description 2
- 208000008454 Hyperhidrosis Diseases 0.000 description 2
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 2
- DATAGRPVKZEWHA-YFKPBYRVSA-N N(5)-ethyl-L-glutamine Chemical compound CCNC(=O)CC[C@H]([NH3+])C([O-])=O DATAGRPVKZEWHA-YFKPBYRVSA-N 0.000 description 2
- CWVRJTMFETXNAD-KLZCAUPSSA-N Neochlorogenin-saeure Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O CWVRJTMFETXNAD-KLZCAUPSSA-N 0.000 description 2
- 206010033557 Palpitations Diseases 0.000 description 2
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 description 2
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 2
- 206010047700 Vomiting Diseases 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 231100000540 amenorrhea Toxicity 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 230000036528 appetite Effects 0.000 description 2
- 235000019789 appetite Nutrition 0.000 description 2
- 208000006673 asthma Diseases 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 235000004883 caffeic acid Nutrition 0.000 description 2
- 229940074360 caffeic acid Drugs 0.000 description 2
- 229960001948 caffeine Drugs 0.000 description 2
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 2
- 230000001914 calming effect Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 235000020235 chia seed Nutrition 0.000 description 2
- 229940074393 chlorogenic acid Drugs 0.000 description 2
- 235000001368 chlorogenic acid Nutrition 0.000 description 2
- CWVRJTMFETXNAD-JUHZACGLSA-N chlorogenic acid Chemical compound O[C@@H]1[C@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-JUHZACGLSA-N 0.000 description 2
- FFQSDFBBSXGVKF-KHSQJDLVSA-N chlorogenic acid Natural products O[C@@H]1C[C@](O)(C[C@@H](CC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O FFQSDFBBSXGVKF-KHSQJDLVSA-N 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- BMRSEYFENKXDIS-KLZCAUPSSA-N cis-3-O-p-coumaroylquinic acid Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)cc2)[C@@H]1O)C(=O)O BMRSEYFENKXDIS-KLZCAUPSSA-N 0.000 description 2
- QAIPRVGONGVQAS-UHFFFAOYSA-N cis-caffeic acid Natural products OC(=O)C=CC1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-UHFFFAOYSA-N 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 230000003750 conditioning effect Effects 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 230000035622 drinking Effects 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 206010022437 insomnia Diseases 0.000 description 2
- 235000008777 kaempferol Nutrition 0.000 description 2
- 230000005906 menstruation Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- UXOUKMQIEVGVLY-UHFFFAOYSA-N morin Natural products OC1=CC(O)=CC(C2=C(C(=O)C3=C(O)C=C(O)C=C3O2)O)=C1 UXOUKMQIEVGVLY-UHFFFAOYSA-N 0.000 description 2
- 201000009240 nasopharyngitis Diseases 0.000 description 2
- 210000005036 nerve Anatomy 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 238000003359 percent control normalization Methods 0.000 description 2
- 238000010791 quenching Methods 0.000 description 2
- 230000000171 quenching effect Effects 0.000 description 2
- 210000004243 sweat Anatomy 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 239000003053 toxin Substances 0.000 description 2
- 231100000765 toxin Toxicity 0.000 description 2
- 229940126680 traditional chinese medicines Drugs 0.000 description 2
- 230000008736 traumatic injury Effects 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 210000001835 viscera Anatomy 0.000 description 2
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 206010000234 Abortion spontaneous Diseases 0.000 description 1
- 208000000044 Amnesia Diseases 0.000 description 1
- 208000031091 Amnestic disease Diseases 0.000 description 1
- 241000208173 Apiaceae Species 0.000 description 1
- 206010003011 Appendicitis Diseases 0.000 description 1
- 208000006400 Arbovirus Encephalitis Diseases 0.000 description 1
- 206010003210 Arteriosclerosis Diseases 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 208000004429 Bacillary Dysentery Diseases 0.000 description 1
- 208000008035 Back Pain Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 229920001342 Bakelite® Polymers 0.000 description 1
- 206010006326 Breath odour Diseases 0.000 description 1
- 206010008631 Cholera Diseases 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 description 1
- 206010052369 Encephalitis lethargica Diseases 0.000 description 1
- 208000004232 Enteritis Diseases 0.000 description 1
- 201000000297 Erysipelas Diseases 0.000 description 1
- 241000208686 Eucommiaceae Species 0.000 description 1
- 244000268590 Euryale ferox Species 0.000 description 1
- 235000006487 Euryale ferox Nutrition 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 208000005577 Gastroenteritis Diseases 0.000 description 1
- 206010017915 Gastroenteritis shigella Diseases 0.000 description 1
- 208000034507 Haematemesis Diseases 0.000 description 1
- 208000032139 Halitosis Diseases 0.000 description 1
- 206010019345 Heat stroke Diseases 0.000 description 1
- 208000000616 Hemoptysis Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 208000035150 Hypercholesterolemia Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- IPMYMEWFZKHGAX-UHFFFAOYSA-N Isotheaflavin Natural products OC1CC2=C(O)C=C(O)C=C2OC1C(C1=C2)=CC(O)=C(O)C1=C(O)C(=O)C=C2C1C(O)CC2=C(O)C=C(O)C=C2O1 IPMYMEWFZKHGAX-UHFFFAOYSA-N 0.000 description 1
- 208000008930 Low Back Pain Diseases 0.000 description 1
- 201000005505 Measles Diseases 0.000 description 1
- 208000037093 Menstruation Disturbances Diseases 0.000 description 1
- 206010027339 Menstruation irregular Diseases 0.000 description 1
- 235000006679 Mentha X verticillata Nutrition 0.000 description 1
- 235000002899 Mentha suaveolens Nutrition 0.000 description 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 1
- 241000218231 Moraceae Species 0.000 description 1
- 208000007443 Neurasthenia Diseases 0.000 description 1
- 206010033425 Pain in extremity Diseases 0.000 description 1
- 206010034038 Parotitis Diseases 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 description 1
- LUJAXSNNYBCFEE-UHFFFAOYSA-N Quercetin 3,7-dimethyl ether Natural products C=1C(OC)=CC(O)=C(C(C=2OC)=O)C=1OC=2C1=CC=C(O)C(O)=C1 LUJAXSNNYBCFEE-UHFFFAOYSA-N 0.000 description 1
- PUTDIROJWHRSJW-UHFFFAOYSA-N Quercitrin Natural products CC1OC(Oc2cc(cc(O)c2O)C3=CC(=O)c4c(O)cc(O)cc4O3)C(O)C(O)C1O PUTDIROJWHRSJW-UHFFFAOYSA-N 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- UXRMWRBWCAGDQB-UHFFFAOYSA-N Theaflavin Natural products C1=CC(C2C(CC3=C(O)C=C(O)C=C3O2)O)=C(O)C(=O)C2=C1C(C1OC3=CC(O)=CC(O)=C3CC1O)=CC(O)=C2O UXRMWRBWCAGDQB-UHFFFAOYSA-N 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 206010047513 Vision blurred Diseases 0.000 description 1
- 206010047601 Vitamin B1 deficiency Diseases 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 208000031975 Yang Deficiency Diseases 0.000 description 1
- 206010000269 abscess Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- OXGUCUVFOIWWQJ-XIMSSLRFSA-N acanthophorin B Natural products O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O OXGUCUVFOIWWQJ-XIMSSLRFSA-N 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 208000012873 acute gastroenteritis Diseases 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 229940024606 amino acid Drugs 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000006986 amnesia Effects 0.000 description 1
- 208000011775 arteriosclerosis disease Diseases 0.000 description 1
- 239000004637 bakelite Substances 0.000 description 1
- 208000002894 beriberi Diseases 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 235000005487 catechin Nutrition 0.000 description 1
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 1
- 230000032677 cell aging Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 229950001002 cianidanol Drugs 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 206010014599 encephalitis Diseases 0.000 description 1
- 208000001780 epistaxis Diseases 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000013401 experimental design Methods 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 201000005577 familial hyperlipidemia Diseases 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 238000009499 grossing Methods 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 208000013403 hyperactivity Diseases 0.000 description 1
- 230000037315 hyperhidrosis Effects 0.000 description 1
- 230000007365 immunoregulation Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 210000004153 islets of langerhan Anatomy 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 208000004396 mastitis Diseases 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 208000015994 miscarriage Diseases 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000020660 omega-3 fatty acid Nutrition 0.000 description 1
- 229940012843 omega-3 fatty acid Drugs 0.000 description 1
- 239000006014 omega-3 oil Substances 0.000 description 1
- 239000003538 oral antidiabetic agent Substances 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 229940067631 phospholipid Drugs 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 235000005875 quercetin Nutrition 0.000 description 1
- 229960001285 quercetin Drugs 0.000 description 1
- OEKUVLQNKPXSOY-UHFFFAOYSA-N quercetin 3-O-beta-D-glucopyranosyl(1->3)-alpha-L-rhamnopyranosyl(1->6)-beta-d-galactopyranoside Natural products OC1C(O)C(C(O)C)OC1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O OEKUVLQNKPXSOY-UHFFFAOYSA-N 0.000 description 1
- QPHXPNUXTNHJOF-UHFFFAOYSA-N quercetin-7-O-beta-L-rhamnopyranoside Natural products OC1C(O)C(O)C(C)OC1OC1=CC(O)=C2C(=O)C(O)=C(C=3C=C(O)C(O)=CC=3)OC2=C1 QPHXPNUXTNHJOF-UHFFFAOYSA-N 0.000 description 1
- OXGUCUVFOIWWQJ-HQBVPOQASA-N quercitrin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O OXGUCUVFOIWWQJ-HQBVPOQASA-N 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 210000004994 reproductive system Anatomy 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- 210000004706 scrotum Anatomy 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 208000013223 septicemia Diseases 0.000 description 1
- 201000005113 shigellosis Diseases 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 206010040872 skin infection Diseases 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 208000000995 spontaneous abortion Diseases 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 235000014620 theaflavin Nutrition 0.000 description 1
- IPMYMEWFZKHGAX-ZKSIBHASSA-N theaflavin Chemical compound C1=C2C([C@H]3OC4=CC(O)=CC(O)=C4C[C@H]3O)=CC(O)=C(O)C2=C(O)C(=O)C=C1[C@@H]1[C@H](O)CC2=C(O)C=C(O)C=C2O1 IPMYMEWFZKHGAX-ZKSIBHASSA-N 0.000 description 1
- 229940026509 theaflavin Drugs 0.000 description 1
- 229940026510 theanine Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 206010044008 tonsillitis Diseases 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 201000002498 viral encephalitis Diseases 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/69—Polygalaceae (Milkwort family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Mycology (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
本发明涉及一种具有降血糖功能的保健食品的制备方法,属于食品加工技术领域。所述保健食品其原料包括黑茶、当归、杜仲、金银花、灵芝、枸杞子、远志、奇亚、香薷、菊花、桑叶、异麦芽低聚糖。该保健食品精心通过选择原料,科学组方,不仅具有降血糖的保健效果,还具有美容养颜、预防高血压、高血脂、抗氧化、延缓衰老、提高免疫力等保健作用。
Description
本申请是对申请日2016.02.01,申请号2016100688082,发明名称“一种具有降血糖功能的保健食品”的发明专利申请的分案申请。
技术领域
本发明涉及一种具有降血糖功能的保健食品,属于食品加工技术领域。
背景技术
随着经济的快速发展,人民生活水平大幅度提高,伴随而来的是人们患高血糖、高血脂的机率也急速上升。在保健食品方面,降血糖、降血脂的保健食品越来越受人们的喜爱。高血脂、高胆固醇、高血压、高血糖都是现在的流行病,降血脂降血压成为一个热门话题。据统计,全世界约有1.5亿糖尿病患者,80%为非胰岛素依赖型糖尿病即II型糖尿病,其中我国有4000多万。目前对糖尿病的治疗主要有化学药物和中药治疗两种,虽然现在化学药物为主要的应用药物,但是由于中药在降血糖的同时还会对胰岛有很好的修复作用,在糖尿病治疗中有着很好的前景。由于糖尿病的终身不可愈性以及耐药性、抗药性及药品的副作用等原因,这类人群对降糖保健食品的需求量非常大。II型糖尿病又称为非胰岛素依赖型糖尿病,高血糖是其主要症状,控制血糖可明显改善并发症的发生及发展。目前市场需求一种能够长期服用的安全降糖的保健食品。
发明内容
为解决上述技术问题,本发明目的在于提供一种具有降血糖功能的保健食品。该保健食品通过精心选择原料,科学组方,不仅具有降血糖的保健效果,还具有美容养颜,预防高血压、高脂血、抗氧化、延缓衰老、提高免疫力等保健作用。
实现本发明目的技术方案如下:
一种具有降血糖功能的保健食品,其原料包括黑茶、当归、杜仲、金银花、灵芝、枸杞子、远志、奇亚、香薷、菊花、桑叶、异麦芽低聚糖。
优选地,所述保健食品,以重量份计,其原料包括黑茶10-200份、当归1-10份、杜仲5-50份、金银花10-200份、灵芝5-50份、枸杞子10-150份、远志5-20份、奇亚5-100份、香薷5-50份、菊花10-200份、桑叶5-100份、异麦芽低聚糖0.1-1份。
进一步优选地,所述保健食品,以重量份计,其原料包括黑茶50-150份、当归2-8份、杜仲10-40份、金银花50-150份、灵芝10-40份、枸杞子50-120份、远志10-15份、奇亚10-80份、香薷10-40份、菊花50-150份、桑叶10-80份、异麦芽低聚糖0.2-0.8份。
较佳地,所述保健食品,以重量份计,其原料包括黑茶120份、当归3份、杜仲15份、金银花70份、灵芝15份、枸杞子80份、远志12份、奇亚50份、香薷30份、菊花85份、桑叶60份、异麦芽低聚糖0.6份。
所述重量份可以是μg、mg、g、kg等本领域公知的重量单位,也可以是其倍数,如1/10、1/100、10倍、100倍等。
上述具有降血糖功能的保健食品,其中黑茶、当归、杜仲、金银花、灵芝、枸杞子、远志、奇亚、香薷、菊花、桑叶、异麦芽低聚糖作为活性成分原料;优选地,上述保健食品其原料或辅料还包括药学上或食品上或保健食品上可接受的载体。
优选地,所述保健食品是制成口服制剂;包括:胶囊剂、颗粒剂、片剂、袋装茶剂、粉剂等;更优选为颗粒剂。
进一步优选地,所述保健食品其原料或辅料还包括微晶纤维素、硬脂酸镁。
本发明还提供上述保健食品的制备方法,该方法包括以下步骤:按照配比称取各成分,混匀,按照常规制剂方法制备成制剂。
优选地,上述保健食品的制备方法包括以下步骤:
1)配料;即按配比称取所需原料(包括黑茶、当归、杜仲、金银花、灵芝、枸杞子、远志、奇亚、香薷、菊花、桑叶、异麦芽低聚糖等);
2)将当归、杜仲、灵芝、远志、奇亚、香薷混合后,加5-10倍重量的50%-90%乙醇回流提取1-3次,每次0.5-3.0小时,滤过,合并滤液,将滤液浓缩至清膏(相对密度为1.10-1.30,30℃),加入乙醇使含醇量达70%-75%,得溶液I;
3)将黑茶、金银花、枸杞子、菊花、桑叶混合后,加5-15倍重量的水煎煮1-3次,每次0.5-2小时,合并煎液,滤过,将滤液浓缩至清膏(相对密度为1.10-1.30,30℃),加乙醇使含醇量达70%-75%,得溶液II;
4)合并所述溶液I和溶液II,搅匀,静置,滤过,滤液回收乙醇,浓缩至清膏(相对密度为1.10-1.30,30℃);按配方加入异麦芽低聚糖和适量辅料制成合适的剂型。优选地,加入适量微晶纤维素、硬脂酸镁,制成颗粒剂。
具体地,上述保健食品的制备方法包括以下步骤:
1)配料;即按配比称取所需原料(包括黑茶、当归、杜仲、金银花、灵芝、枸杞子、远志、奇亚、香薷、菊花、桑叶、异麦芽低聚糖等);
2)将当归、杜仲、灵芝、远志、奇亚、香薷混合后,用70%-75%乙醇回流提取2次,第1次加入8倍重量乙醇提取3h,第2次加入6倍重量乙醇提取1h,滤过,合并滤液,将滤液浓缩至清膏(相对密度为1.10-1.30,30℃),加入乙醇使含醇量达70%-75%,得溶液I;
3)将黑茶、金银花、枸杞子、菊花、桑叶混合后,加水煎煮2次,第1次加入10倍重量水煎煮2h,第2次加入8倍重量乙醇提取1h,合并煎液,滤过,将滤液浓缩至清膏(相对密度为1.10-1.30,30℃),加乙醇使含醇量达70%-75%,得溶液II;
4)合并所述溶液I和溶液II,搅匀,静置,滤过,滤液回收乙醇,浓缩至清膏(相对密度为1.10-1.30,30℃);按配方加入异麦芽低聚糖和适量辅料制成合适的剂型;优选地,加入适量微晶纤维素、硬脂酸镁,制成颗粒剂。
如无特殊说明,本发明所述乙醇浓度均指体积浓度。
实验证明,本发明采用上述工艺对中药材原料进行提取,最大程度保留了中药原料的有效成份,并且提取的有效成分最易于被人体吸收,增强药物的吸收,从而避免了无效成分干扰药效的问题。
黑茶(dark tea),因成品茶的外观呈黑色,故得名,为六大茶类之一,属后发酵茶。黑茶中的咖啡碱、维生素、氨基酸、磷脂等有助于人体消化,调节脂肪代谢,咖啡碱的刺激作用更能提高胃液的分泌量,从而增进食欲,帮助消化。科学检验已证明,黑茶具有很强的解油腻、消食等功能,这也是肉食民族特别喜欢这种茶的原因。另外,黑茶还能改善肠道微生物环境,具有顺肠胃的功能。我国民间有利用老黑茶治疗腹胀、痢疾、不消食的传统。同时,黑茶中的儿茶素、茶黄素、茶氨酸和茶多糖,尤其是含量较多的复杂类黄酮等都具有清除自由基的功能,因而具有抗氧化、延缓细胞衰老的作用。
当归为伞形科植物当归Angelica sinensis(Oliv.)Diels的干燥根,具有补血活血,调经止痛,润肠通便之功效。常用于血虚萎黄,眩晕心悸,***,经闭痛经,虚寒腹痛,风湿痹痛,跌扑损伤,痈疽疮疡,肠燥便秘。酒当归活血通经。用于经闭痛经,风湿痹痛,跌扑损伤。
杜仲Eucommia ulmoides Oliver,又名胶木,为杜仲科植物杜仲的干燥树皮。其味甘,性温。有补益肝肾、强筋壮骨、调理冲任、固经安胎的功效。可治疗肾阳虚引起的腰腿痛或酸软无力,肝气虚引起的胞胎不固,阴囊湿痒等症。在《神农本草经》中被列为上品。现代研究杜仲具有清除体内垃圾,加强人体细胞物质代谢,防止肌肉骨骼老化,平衡人体血压,分解体内胆固醇,降低体内脂肪,恢复血管弹性,利尿清热,广谱抗菌,兴奋中枢神经,提高白血球药理作用。
金银花性寒,味甘,入肺、心、胃经,具有清热解毒、抗炎、补虚疗风的功效,主治胀满下疾、温病发热,热毒痈疡和肿瘤等症。其对于头昏头晕、口干作渴、多汗烦闷、肠炎、菌痢、麻疹、肺炎、乙脑、流脑、急性乳腺炎、败血症、阑尾炎、皮肤感染、痈疽疔疮、丹毒、腮腺炎、化脓性扁桃体炎等病症均有一定疗效。金银花可改善微循环,清除过氧化脂肪沉积,促进新陈代谢;杜仲补气和增进脾脏功能和代谢能力低下。
灵芝具有补气安神、止咳平喘的功效,用于眩晕不眠、心悸气短、神经衰弱、虚劳咳喘,延年益寿。灵芝具有促进血液循环的作用,可以使一些细小血管的血液缓滞现象,得到显著的改善。同样,灵芝也可以加快面部一些细小的血管的血液循环,使皮肤细胞得到充分的营养物质和氧气,促进皮肤的新陈代谢。
枸杞性甘、平,归肝肾经,具有滋补肝肾,养肝明目的功效。现代医学研究证明:枸杞有免疫调节、抗氧化、抗衰老、抗肿瘤、抗疲劳、降血脂、降血糖、降血压、补肾、保肝、明目、养颜、健脑、排毒、保护生殖***、抗辐射损伤等十六项功能。另外,还能起到美白作用,这是因为枸杞子可以提高皮肤吸收氧分的能力。
远志Polygala tenuifolia Willd具有安神益智、祛痰、消肿的功能,性味苦、辛、温。归经归心、肾、肺经。用于心肾不交引起的失眠多梦、健忘惊悸,神志恍惚,咳痰不爽,疮疡肿毒,***肿痛。
奇亚(Chia Seed)又名奇雅子、奇亚籽,学名芡欧鼠尾草(Salvia Hispanica L.),薄荷类植物,原产地为墨西哥南部和危地马拉等北美洲地区。本发明所述奇亚,是该植物的种子——奇亚籽。奇亚它是富含omega-3脂肪酸最丰富的食物,并且含有天然抗氧化剂。除了普通的抗氧化元素(维生素E,C和卵磷脂)以外,奇亚籽内含有更丰富的天然抗氧化剂,是抗老防病防癌的必需:咖啡酸(caffeic acid)可以预防动脉硬化;绿原酸(chlorogenicacid)有效抑制癌变,并有减肥作用;其它抗氧剂如栎皮黄素(quercetin),山柰黄酮醇(kaempferol)等也是防癌,抗老化的有效物质。
香薷能发汗解表,化湿和中,利水消肿。主治:夏月感寒饮冷,头痛发热,恶寒无汗,胸痞腹痛,呕吐腹泻,水肿,脚气。既能发汗而解表,又能化湿和中而解暑,还能开宣肺气而利水消肿。功似麻黄,药力亦强,治阴寒闭暑及风水水肿最宜,故素有“夏月麻黄”之称。治急性肠胃炎、腹痛吐泻、夏秋阳暑、头痛发热、恶寒无汗、霍乱、水肿、鼻衄、口臭等症。
菊花性味味苦、甘,性微寒。归经归肺、肝经。功效散风清热,平肝明目,清热解毒。菊花能入药治病,久服或饮菊花茶能令人长寿。应用:风热感冒,温病初起;肝阳眩晕,肝风实证;目赤昏花;疮痈肿毒等。
桑叶是桑科植物桑的干燥叶,性味味苦、甘,性寒。归经归肺、肝经。功效疏散风热,清肺润燥,平肝明目,凉血止血。主治风热感冒,温病初起,肺热咳嗽,肝阳上亢眩晕,目赤昏花,血热妄行之咳血、吐血。
本发明以传统中医药学理论为指导,结合现代医学研究,从养生学角度精心选择原料,科学组方,达到降血糖的保健效果,另外还具有养颜美容、颐养生命、增强体质、预防疾病、延年益寿的保健功能。本发明注重人体整体的调理和内在的调理,结合养生学研制出的保健食品不仅具有降血糖的保健效果,还能够促进人体的健康长寿。
本发明组方原则:以黑茶、枸杞子为君,以灵芝、杜仲、菊花为臣,以当归、金银花、桑叶为佐,以远志、奇亚、香薷、异麦芽低聚糖为使,以辅助提高产品降血糖的功效。诸药合用,共奏清热止渴、养阴生津、滋阴润燥并兼有润肺、清胃、滋肾之功效;并具益气活血,排毒养颜之功效,可爽肤润肤,悦泽颜面。本发明精选原料调理人体五脏,综合作用达到消渴降糖的保健效果。其中通过调理心脏使心气旺盛,心血充盈;肝主藏血,通过调理肝脏使气血平和;脾为后天之本,气血生化之源;通过调理脾胃,使其功能健运,气血旺盛;肺主皮毛,通过调理肺使气血津液得以布散全身;肾主藏精,通过调理肾脏,使肾精充盈,肾气旺盛时,五脏功能也将正常运行,气血旺盛,健体强身。
本发明保健食品是一种以追求时尚的、又兼顾传统的品饮方式,来达到在惬意中有益于中老年和亚健康人群保健的目的。本发明保健食品作用温和,药效稳定,无毒副作用,适合长期饮用。研究发现,长期服用本发明保健食品还具有预防高血压、高脂血、抗氧化、延缓衰老、提高免疫力等保健作用。
具体实施方式
以下实施例用于说明本发明,但不用来限制本发明的范围。实施例中未注明具体技术或条件者,按照本领域内的文献所描述的技术或条件,或者按照产品说明书进行。所用试剂或仪器未注明生产厂商者,均为可通过正规渠道商购买得到的常规产品。
实施例1
一种具有降血糖功能的保健食品,以重量份计其原料包括黑茶10份、当归1份、杜仲5份、金银花10份、灵芝5份、枸杞子10份、远志5份、奇亚5份、香薷5份、菊花10份、桑叶5份、异麦芽低聚糖0.1份。
实施例2
一种具有降血糖功能的保健食品,以重量份计其原料包括黑茶200份、当归10份、杜仲50份、金银花200份、灵芝50份、枸杞子150份、远志20份、奇亚100份、香薷50份、菊花200份、桑叶100份、异麦芽低聚糖1份。
实施例3
一种具有降血糖功能的保健食品,以重量份计其原料包括黑茶150份、当归2份、杜仲10份、金银花150份、灵芝10份、枸杞子120份、远志10份、奇亚10份、香薷40份、菊花150份、桑叶80份、异麦芽低聚糖0.8份。
实施例4
一种具有降血糖功能的保健食品,以重量份计其原料包括黑茶50份、当归8份、杜仲40份、金银花50份、灵芝40份、枸杞子50份、远志15份、奇亚80份、香薷10份、菊花50份、桑叶10份、异麦芽低聚糖0.2份。
实施例5
一种具有降血糖功能的保健食品,以重量份计其原料包括黑茶120份、当归3份、杜仲15份、金银花70份、灵芝15份、枸杞子80份、远志12份、奇亚50份、香薷30份、菊花85份、桑叶60份、异麦芽低聚糖0.6份。
实施例6
一种具有降血糖功能的保健食品,其配方与实施例1相同,该保健食品的制备方法包括以下步骤:
1)配料;即按配比称取所需原料;
2)将当归、杜仲、灵芝、远志、奇亚、香薷混合后,加5倍重量的90%乙醇回流提取3次,每次0.5小时,滤过,合并滤液,将滤液浓缩至清膏(相对密度为1.30,30℃),加入乙醇使含醇量达75%,得溶液I;
3)将黑茶、金银花、枸杞子、菊花、桑叶混合后,加5倍重量的水煎煮3次,每次0.5小时,合并煎液,滤过,将滤液浓缩至清膏(相对密度为1.30,30℃),加乙醇使含醇量达75%,得溶液II;
4)合并所述溶液I和溶液II,搅匀,静置,滤过,滤液回收乙醇,浓缩至清膏(相对密度为1.30,30℃);按配方加入异麦芽低聚糖,制得活性混合物;取该活性混合物100份,添加麦芽糊精12.5份、微晶纤维素55.5份,混合均匀,加适量乙醇溶液制软材,16目筛制粒,60℃干燥,12目筛整粒即颗粒剂。
产品规格20g/袋;建议食用方法及食用量:每日2次,每次1袋,温开水冲服;保质期24个月;贮藏方法常温、通风、干燥处。
实施例7
一种具有降血糖功能的保健食品,其配方与实施例2相同,该保健食品的制备方法包括以下步骤:
1)配料;即按配比称取所需原料;
2)将当归、杜仲、灵芝、远志、奇亚、香薷混合后,加10倍重量的50%乙醇回流提取1次,每次3.0小时,滤过,合并滤液,将滤液浓缩至清膏(相对密度为1.10,30℃),加入乙醇使含醇量达70%,得溶液I;
3)将黑茶、金银花、枸杞子、菊花、桑叶混合后,加15倍重量的水煎煮1次,每次2小时,合并煎液,滤过,将滤液浓缩至清膏(相对密度为1.10,30℃),加乙醇使含醇量达70%,得溶液II;
4)合并所述溶液I和溶液II,搅匀,静置,滤过,滤液回收乙醇,浓缩至清膏(相对密度为1.10,30℃);按配方加入异麦芽低聚糖,制得活性混合物;取该活性混合物100份,添加麦芽糊精12.5份、微晶纤维素55.5份,混合均匀,加适量乙醇溶液制软材,16目筛制粒,60℃干燥,12目筛整粒即颗粒剂。
产品规格20g/袋;建议食用方法及食用量:每日2次,每次1袋,温开水冲服;保质期24个月;贮藏方法常温、通风、干燥处。
实施例8
一种具有降血糖功能的保健食品,其配方与实施例3相同,该保健食品的制备方法包括以下步骤:
1)配料;即按配比称取所需原料;
2)将当归、杜仲、灵芝、远志、奇亚、香薷混合后,用70%乙醇回流提取2次,第1次加入8倍重量乙醇提取3h,第2次加入6倍重量乙醇提取1h,滤过,合并滤液,将滤液浓缩至清膏(相对密度为1.10,30℃),加入乙醇使含醇量达70%,得溶液I;
3)将黑茶、金银花、枸杞子、菊花、桑叶混合后,加水煎煮2次,第1次加入10倍重量水煎煮2h,第2次加入8倍重量乙醇提取1h,合并煎液,滤过,将滤液浓缩至清膏(相对密度为1.10,30℃),加乙醇使含醇量达70%,得溶液II;
4)合并所述溶液I和溶液II,搅匀,静置,滤过,滤液回收乙醇,浓缩至清膏(相对密度为1.10,30℃);按配方加入异麦芽低聚糖,制得活性混合物;取该活性混合物100份,添加麦芽糊精12.5份、微晶纤维素55.5份,混合均匀,加适量乙醇溶液制软材,16目筛制粒,60℃干燥,12目筛整粒即颗粒剂。
产品规格20g/袋;建议食用方法及食用量:每日2次,每次1袋,温开水冲服;保质期24个月;贮藏方法常温、通风、干燥处。
实施例9
一种具有降血糖功能的保健食品,其配方与实施例5相同,该保健食品的制备方法包括以下步骤:
1)配料;即按配比称取所需原料;
2)将当归、杜仲、灵芝、远志、奇亚、香薷混合后,用75%乙醇回流提取2次,第1次加入8倍重量乙醇提取3h,第2次加入6倍重量乙醇提取1h,滤过,合并滤液,将滤液浓缩至清膏(相对密度为1.30,30℃),加入乙醇使含醇量达75%,得溶液I;
3)将黑茶、金银花、枸杞子、菊花、桑叶混合后,加水煎煮2次,第1次加入10倍重量水煎煮2h,第2次加入8倍重量乙醇提取1h,合并煎液,滤过,将滤液浓缩至清膏(相对密度为1.30,30℃),加乙醇使含醇量达75%,得溶液II;
4)合并所述溶液I和溶液II,搅匀,静置,滤过,滤液回收乙醇,浓缩至清膏(相对密度为1.30,30℃);按配方加入异麦芽低聚糖,制得活性混合物;取该活性混合物100份,添加麦芽糊精12.5份、微晶纤维素55.5份,混合均匀,加适量乙醇溶液制软材,16目筛制粒,60℃干燥,12目筛整粒即颗粒剂。
产品规格20g/袋;建议食用方法及食用量:每日2次,每次1袋,温开水冲服;保质期24个月;贮藏方法常温、通风、干燥处。
实施例10
一种具有降血糖功能的保健食品,其配方与实施例4相同,该保健食品的制备方法同实施例9。
产品规格20g/袋;建议食用方法及食用量:每日2次,每次1袋,温开水冲服;保质期24个月;贮藏方法常温、通风、干燥处。
实施例11
一种具有降血糖功能的保健食品,其配方与实施例1相同,为按常规方法制成的袋装茶剂。
实施例12
一种具有降血糖功能的保健食品,其配方与实施例2相同,为按常规方法制成的胶囊剂。
实施例13
一种具有降血糖功能的保健食品,其配方与实施例3相同,其制备方法包括先按实施例8的方法制成制得活性混合物;再常规方法制成片剂。
实施例14
一种具有降血糖功能的保健食品,其配方与实施例4相同,其制备方法包括先按实施例9的方法制成制得活性混合物;再常规方法制成胶囊剂。
实施例15
一种具有降血糖功能的保健食品,其配方与实施例5相同,其制备方法包括先按实施例8的方法制成制得活性混合物;再常规方法制成片剂。
对比例
一种黑茶颗粒剂,其活性成分仅为黑茶;其制备方法与实施例9相同(但原料不包括黑茶之外的中药材和异麦芽低聚糖)。
实验例 降血糖功能实验
1、试验人群:选择100名成年Ⅱ型糖尿病人,年龄18-65岁,男女各半。受试者纳入标准为,选择年龄18-65岁,饮食控制或口服降糖药治疗后病情稳定,不需要更换药物品种及剂量,仅服用维持量的成年Ⅱ型糖尿病人,空腹血糖≥7.8mmol/L或餐后2h血糖≥11.1mmol/L。
2、试验设计与分组:按受试者血糖水平、性别、年龄、病程、服药种类均衡随机分为实验组和对照组,每组50人。
3、试验方法:实验组每天服用本发明实施例9所制备样品,剂量为每日2次,每次1袋(20g/袋),开水冲泡后饮用。对照组服用对比例制备的黑茶颗粒剂,对照组服用剂量及方法与实验组相同。试验周期30天。试验前对每一受试者按性别、年龄、不同劳动强度、理想体重,参照原来生活习惯规定相应的饮食,试验期间各组坚持饮食控制,原用药物种类和剂量不变。
4、功效观察:观察受试者试验期间临床症状,并测定空腹血糖、餐后血糖和尿糖。
5、试验结果
5.1临床症状观察
表1临床症状积分统计(x±s)
组别 | 例数 | 试食前 | 试食后 |
对照组 | 50 | 5.59±3.27 | 5.47±3.12 |
实验组 | 50 | 5.73±3.41 | 3.65±2.61*# |
注:*与实验组比较P<0.05;#与对照组比较P<0.05。
表2临床症状改善情况
由表1、2可见,实验组临床症状有明显改善,与对照组比较,差异显著(P<0.05)。
5.2空腹血糖
表3试食前后空腹血糖变化(单位:mmol/L,x±s)
组别例数(n) | 试食前 | 试食后 | 血糖下降幅度 | 下降百分率% |
对照组50 | 9.10±2.00 | 9.06±2.03 | 0.03±0.22 | 0.44 |
实验组50 | 9.13±2.11 | 7.97±2.02*# | 1.15±0.51*# | 12.71 |
注:*与实验组比较P<0.05;#与对照组比较P<0.05。
5.3餐后血糖
表4试食前后餐后血糖变化(单位:mmol/L,x±s)
组别例数(n) | 试食前 | 试食后 | 血糖下降幅度 | 下降百分率% |
对照组50 | 12.20±2.11 | 12.15±2.05 | 0.05±0.25 | 0.41 |
实验组50 | 12.23±2.21 | 11.09±2.24*# | 1.13±0.62*# | 9.32 |
注:*与实验组比较P<0.05;#与对照组比较P<0.05
6、结论
实验组服用本发明实施例9样品对于高血糖症的主要临床症状有明显改善作用;实验组空腹血糖、餐后血糖及尿糖,试食前后自身比较及实验组与对照组比较,差异均有显著性(P<0.05)。试验结果表明,本发明产品具有降血糖的保健作用。
本实验例中采取颗粒剂的剂型,使药物服用简单便利,有效的提高了药物的吸收及利用,此外,本发明采取的是纯天然药物,不添加任何的有毒添加剂及成瘾性药物,不会抑制食欲,不会导致腹泻,无毒副作用,不成瘾。实验时还发现,大部分实验组受试者的体重有所减轻,且血脂、血压有不同程度降低,消化均有改善,精神面貌显著改善,提示本发明还具有降血脂、降血压及减肥等保健作用。
虽然,上文中已经用一般性说明及具体实施方案对本发明作了详尽的描述,但在本发明基础上,可以对之作一些修改或改进,这对本领域技术人员而言是显而易见的。因此,在不偏离本发明精神的基础上所做的这些修改或改进,均属于本发明要求保护的范围。
Claims (4)
1.一种辅助降血糖保健食品的制备方法,其特征在于,包括以下步骤:
1)配料;
所述保健食品的原料为:黑茶50-150份、当归2-8份、杜仲10-40份、金银花50-150份、灵芝10-40份、枸杞子50-120份、远志10-15份、奇亚10-80份、香薷10-40份、菊花50-150份、桑叶10-80份、异麦芽低聚糖0.2-0.8份;
2)将当归、杜仲、灵芝、远志、奇亚、香薷混合后,加5-10倍重量的50%-90%乙醇回流提取1-3次,每次0.5-3.0小时,滤过,合并滤液,将滤液浓缩至清膏,加入乙醇使含醇量达70%-75%,得溶液I;
3)将黑茶、金银花、枸杞子、菊花、桑叶混合后,加5-15倍重量的水煎煮1-3次,每次0.5-2小时,合并煎液,滤过,将滤液浓缩至清膏,加乙醇使含醇量达70%-75%,得溶液II;
4)合并所述溶液I和溶液II,搅匀,静置,滤过,滤液回收乙醇,浓缩至清膏;按配方加入异麦芽低聚糖和适量辅料制成合适的剂型。
2.根据权利要求1所述辅助降血糖保健食品的制备方法,其特征在于,步骤4)所述辅料为微晶纤维素、硬脂酸镁;所述剂型为颗粒剂。
3.根据权利要求1所述辅助降血糖保健食品的制备方法,其特征在于,包括以下步骤:
1)配料;
2)将当归、杜仲、灵芝、远志、奇亚、香薷混合后,用70%-75%乙醇回流提取2次,第1次加入8倍重量乙醇提取3h,第2次加入6倍重量乙醇提取1h,滤过,合并滤液,将滤液浓缩至清膏,加入乙醇使含醇量达70%-75%,得溶液I;
3)将黑茶、金银花、枸杞子、菊花、桑叶混合后,加水煎煮2次,第1次加入10倍重量水煎煮2h,第2次加入8倍重量乙醇提取1h,合并煎液,滤过,将滤液浓缩至清膏,加乙醇使含醇量达70%-75%,得溶液II;
4)合并所述溶液I和溶液II,搅匀,静置,滤过,滤液回收乙醇,浓缩至清膏;按配方加入异麦芽低聚糖和适量辅料制成合适的剂型。
4.根据权利要求1-3任一项所述辅助降血糖保健食品的制备方法,其特征在于,所述保健食品的原料为:黑茶120份、当归3份、杜仲15份、金银花70份、灵芝15份、枸杞子80份、远志12份、奇亚50份、香薷30份、菊花85份、桑叶60份、异麦芽低聚糖0.6份。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910901417.8A CN110664906B (zh) | 2016-02-01 | 2016-02-01 | 一种具有降血糖功能的保健食品的制备方法 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910901417.8A CN110664906B (zh) | 2016-02-01 | 2016-02-01 | 一种具有降血糖功能的保健食品的制备方法 |
CN201610068808.2A CN105708970B (zh) | 2016-02-01 | 2016-02-01 | 一种具有降血糖功能的保健食品 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610068808.2A Division CN105708970B (zh) | 2016-02-01 | 2016-02-01 | 一种具有降血糖功能的保健食品 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN110664906A CN110664906A (zh) | 2020-01-10 |
CN110664906B true CN110664906B (zh) | 2021-11-02 |
Family
ID=56154576
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610068808.2A Active CN105708970B (zh) | 2016-02-01 | 2016-02-01 | 一种具有降血糖功能的保健食品 |
CN201910900400.0A Active CN110613134B (zh) | 2016-02-01 | 2016-02-01 | 具有降血糖功能的保健食品及其制备方法 |
CN201910901417.8A Active CN110664906B (zh) | 2016-02-01 | 2016-02-01 | 一种具有降血糖功能的保健食品的制备方法 |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610068808.2A Active CN105708970B (zh) | 2016-02-01 | 2016-02-01 | 一种具有降血糖功能的保健食品 |
CN201910900400.0A Active CN110613134B (zh) | 2016-02-01 | 2016-02-01 | 具有降血糖功能的保健食品及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (3) | CN105708970B (zh) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106172965A (zh) * | 2016-06-30 | 2016-12-07 | 安化盈泰丰农业发展有限公司 | 一种天然环保美颜的新型安化黑茶及其制作方法 |
CN106418529A (zh) * | 2016-08-02 | 2017-02-22 | 马佳 | 提高免疫力的菊花口服液制备方法及其口服液 |
CN108260682A (zh) * | 2018-01-16 | 2018-07-10 | 刘畅 | 一种降血糖、降血脂和降血压的保健茶 |
JP2019022520A (ja) * | 2018-10-19 | 2019-02-14 | 株式会社東洋新薬 | 組成物 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101233912A (zh) * | 2007-10-24 | 2008-08-06 | 杨啸 | 保健功能食盐 |
CN103141606A (zh) * | 2013-03-12 | 2013-06-12 | 胡孔佑 | 一种补血养气速溶黑茶及其制备方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002370994A (ja) * | 2001-06-08 | 2002-12-24 | Kirin Brewery Co Ltd | 血糖値上昇抑制物質及びそれを含む機能性飲食品 |
CN1274242C (zh) * | 2004-08-12 | 2006-09-13 | 陈希萍 | 一种基于人体体质学的红茶菌剂产品的制备方法 |
CN1305405C (zh) * | 2004-12-09 | 2007-03-21 | 桂林莱茵生物制品有限公司 | 一种能辅助降血糖、辅助降血脂的保健食品及其制备方法 |
CN1660387A (zh) * | 2004-12-29 | 2005-08-31 | 韦平生 | 调理人体内脏各器官机能平衡的保健制剂及其制备方法 |
CN1915050B (zh) * | 2006-08-31 | 2010-05-12 | 王学清 | 灵芝茶及其加工工艺 |
CN101401601B (zh) * | 2006-10-18 | 2011-01-26 | 吴建生 | “降三高(血压、血脂、血糖)”五叶仙茶 |
CN102919836B (zh) * | 2012-11-09 | 2015-04-22 | 刘东元 | 一种降糖、降压、降脂、通便养颜、减肥、抗疲劳保健品及其生产工艺 |
CN103315090B (zh) * | 2013-07-11 | 2014-06-11 | 山东华夏茶联茶业有限公司 | 一种黑茶类茶品的配制方法 |
CN103705578B (zh) * | 2013-12-18 | 2015-09-02 | 广西中医药大学 | 具有降血脂与抑制血糖升高作用的中药制剂及其制备方法 |
-
2016
- 2016-02-01 CN CN201610068808.2A patent/CN105708970B/zh active Active
- 2016-02-01 CN CN201910900400.0A patent/CN110613134B/zh active Active
- 2016-02-01 CN CN201910901417.8A patent/CN110664906B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101233912A (zh) * | 2007-10-24 | 2008-08-06 | 杨啸 | 保健功能食盐 |
CN103141606A (zh) * | 2013-03-12 | 2013-06-12 | 胡孔佑 | 一种补血养气速溶黑茶及其制备方法 |
Also Published As
Publication number | Publication date |
---|---|
CN110613134B (zh) | 2022-04-01 |
CN110664906A (zh) | 2020-01-10 |
CN105708970A (zh) | 2016-06-29 |
CN105708970B (zh) | 2019-08-23 |
CN110613134A (zh) | 2019-12-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN107296949A (zh) | 药食同源复合制剂及其制备方法和应用 | |
CN111956753B (zh) | 一种药食同源的中药组合物及其制备方法和应用 | |
CN110664906B (zh) | 一种具有降血糖功能的保健食品的制备方法 | |
CN106035861A (zh) | 一种具有保健功能的桦褐孔菌代用茶及其制备方法 | |
CN112314819A (zh) | 一种改善睡眠的植物饮料及其制备方法 | |
CN107156590A (zh) | 植物固体饮料及其制备方法 | |
CN102920806B (zh) | 安神降压中药茶 | |
CN106333010A (zh) | 一种袋泡减肥瘦身茶及其制备方法 | |
CN111840394B (zh) | 一种用于失眠的药物组合物及其制备方法 | |
CN105532991A (zh) | 一种具有养颜美容功能的复合黑茶及其制备方法 | |
CN106343091A (zh) | 一种减肥瘦身茶凉茶饮料及其制备方法 | |
CN108813501A (zh) | 具有清热润肺止咳化痰平喘和调节人体机能的养生蜂蜜膏 | |
CN107998240A (zh) | 一种提神醒脑缓解疲劳清咽保健含片的配方及其制备方法 | |
CN101190250B (zh) | 一种防治高原病的咀嚼片及其制备方法 | |
CN104225295B (zh) | 用于改善睡眠的组合物及其制备方法和应用 | |
CN102640920A (zh) | 一种食品美容茶冲剂 | |
CN108403933A (zh) | 一种月子餐下奶康复气血双补中药组合物及其制备方法 | |
CN105995711A (zh) | 一种滇橄榄复方制剂及其制备方法 | |
CN103689602B (zh) | 一种高丽红参口服液的制备方法 | |
CN110916036A (zh) | 一种佐酒露及其制备方法 | |
CN108478739A (zh) | 一种调节阴阳平衡的保健品及其制备方法 | |
CN103444932A (zh) | 一种冬季养身下午茶袋泡茶 | |
CN116251152B (zh) | 用于生发乌发的中药组合物、中药制剂的制备方法以及应用 | |
CN117503833B (zh) | 一种食药两用的壮阳补肾中药组合物及其制备方法 | |
CN101274080A (zh) | 一种消除皮肤痤疮、泻火败毒抗菌片剂的组配方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant |