CN110621292A - Dentifrice composition - Google Patents

Abstract

A dentifrice composition comprising 0.00001 to 0.01 mass% of (A) N- (4-cyanomethylphenyl) -2-isopropyl-5-methylcyclohexanecarboxamide, 1.4 to 2.5 mass% of (B) xanthan gum and (C) at least 1 selected from sodium polyacrylate and sodium alginate, wherein the mass ratio of (B)/(C) is 6 to 20. The dentifrice composition further contains (D) thickening silica or (E) a surfactant. The present invention can provide a dentifrice composition which can provide a sustained and high feeling of cleanness in the oral cavity and which is excellent in usability.

Description

Dentifrice composition

Technical Field

The present invention relates to a dentifrice composition which provides a sustained and high feeling of cleanness in the oral cavity and is excellent in usability.

Background

The act of brushing teeth with the dentifrice composition is often performed in order to prevent oral diseases such as tooth decay and periodontal disease, and halitosis, and to provide a fresh clean feeling in the oral cavity.

In some dentifrice compositions, a refreshing agent such as a flavor such as menthol or peppermint oil, or a cold feeling agent such as menthyl lactate may be mixed to give a cold feeling during cleansing. In recent years, the development of a cold-sensitive agent that exerts a strong cold sensation has been actively pursued, and N-substituted-p-menthane-carboxamide and the like are well known. The above-mentioned refreshing agents and cold feeling agents are considered to have an effect of giving a cold feeling during cleansing of the teeth or immediately after gargling.

Patent documents 1 to 6 (Japanese patent laid-open Nos. 2014-125440, 2015-182983, 2016-102076, 2014-507440, 2012-508741 and 2011-520925) propose oral compositions in which a cooling or cooling agent, i.e., N-substituted-p-menthane-carboxamide, improves the cooling or cooling sensation.

Documents of the prior art

Patent document

[ patent document 1 ] Japanese patent laid-open No. 2014-125440

[ patent document 2 ] Japanese patent laid-open No. 2015-182983

[ patent document 3 ] Japanese patent laid-open No. 2016-102076

[ patent document 4 ] Japanese Kohyo 2014-507440 publication

[ patent document 5 ] Japanese Kokai publication No. 2012-508741

[ patent document 6 ] Japanese Kokai publication 2011-520925

[ patent document 7 ] Japanese patent laid-open No. 2012 and 97057

[ patent document 8 ] Japanese patent laid-open No. 2009-149540

Disclosure of Invention

Problems to be solved by the invention

However, there is still room for improvement in satisfying the refreshing clean feeling in the oral cavity, and there is a problem particularly in the sense of sustained feeling, and it cannot be said that the sustained feeling is sufficient. When the amount of the refreshing agent or the cool feeling agent is increased, the cool feeling can be improved to some extent, but the sense of incompatibility due to irritation in the oral cavity, taste, and the like may become strong, and a good clean feeling may not be obtained.

The present invention has been made in view of the above circumstances, and an object thereof is to provide a dentifrice composition which provides a sustained and high feeling of cleanness in the oral cavity and is excellent in usability.

Means for solving the problems

In order to achieve the above object, the present inventors have intensively studied and, as a result, found that: when a specific amount of xanthan gum and 1 or more selected from sodium polyacrylate and sodium alginate are mixed in a specific ratio in a dentifrice composition containing a specific amount of a specific N-substituted-p-menthane-carboxamide, the effect of imparting a clean feeling to the oral cavity can be increased, the feeling of persistence can be improved, and the usability can be maintained. Namely, it was found that: the present invention has been completed by the fact that a dentifrice composition containing 0.00001 to 0.01 mass% of (A) N- (4-cyanomethylphenyl) -2-isopropyl-5-methylcyclohexanecarboxamide, 1.4 to 2.5 mass% of (B) xanthan gum and (C) at least one member selected from the group consisting of sodium polyacrylate and sodium alginate in a mass ratio of (B)/(C) of 6 to 20 can provide a sustained and high feeling of cleanliness in the oral cavity and can maintain a good usability that is easy to put on a toothbrush and does not have an incompatible feeling.

The effect of imparting a clean feeling in the oral cavity by N-substituted-p-menthane-carboxamide is not sufficient, but in the present invention, when component (a) is combined with component (B) and component (C), the mass ratio of (B)/(C) is within a specific range, and the dentifrice retains good usability and exerts an effect of imparting an excellent clean feeling in the oral cavity. The effect of the present invention is an excellent effect obtained only by a combined system of components (B) and (C) in component (a), and when component (a), (B) or (C) is absent, or even when component (a), (B) and (C) are contained, the content of components (a) and (B) is not appropriate, or the mass ratio of (B)/(C) is not appropriate, the effect is poor.

As shown in the following comparative examples, when the composition (a) and the composition (C) were contained and the composition (B) was absent, the oral cavity cleaning feeling was poor even when the composition contained sodium carboxymethylcellulose, which is known as an organic binder component as in the case of the composition (B) and the composition (C) (comparative examples 1 and 5). Further, even when an unsuitable N-substituted-p-menthanecarboxamide or menthyl lactate was used as a cooling agent instead of component (a), the feeling of cleanness in the oral cavity was not maintained even when components (B) and (C) were included (comparative examples 8 and 9). Further, when the composition contains the components (a) and (B) and lacks the component (C), even if the composition contains thickening silica as an inorganic binder, the composition is difficult to put on a toothbrush, and the composition cannot maintain usability to improve the feeling of cleanness in the oral cavity (comparative example 10).

In more detail, the present invention has been studied from the viewpoint that excellent clean feeling in the oral cavity after cleansing, particularly, the continuation of clean feeling, is deeply related not only to the selection of an appropriate clean feeling-imparting component but also to the composition of a dentifrice. As a result, the above-mentioned specific and excellent action and effect can be obtained by using the component (a) as a clean feeling imparting agent in a specific amount, and using a binder system in which the component (B) as a binder is used in combination in a specific amount or more and the component (C) is used in a specific ratio as a dentifrice component. It is presumed that, in this case, the quality of the foam obtained by mixing a specific amount of the component (B) with the component (a) contributes to enhancing the cool and cool feeling of the component (a), thereby providing a sustained and excellent feeling of cleanness in the oral cavity, and further, by mixing the component (C), a good usability which is easy to put on a toothbrush can be maintained by a combined system of the components (a) and (B).

In addition, patent documents 7 and 8 (japanese patent laid-open nos. 2012 and 97057 and 2009 and 149540) do not deal with improvement of foam performance and intraoral dispersibility when a dentifrice composition is used, and improvement of clean feeling in the oral cavity after gargling, which are obtained by using xanthan gum. From patent documents 1 to 6, and further from patent documents 7 and 8, it cannot be predicted that the combination of the components (B) and (C) in the component (a) in specific amounts and ratios according to the present invention imparts a sustained and excellent feeling of cleanness in the oral cavity.

Accordingly, the present invention provides the dentifrice compositions described below.

[ 1 ] A dentifrice composition comprising

0.00001 to 0.01 mass% of (A) N- (4-cyanomethylphenyl) -2-isopropyl-5-methylcyclohexanecarboxamide, 1.4 to 2.5 mass% of (B) xanthan gum, and

(C) more than 1 selected from sodium polyacrylate and sodium alginate,

and (B)/(C) is 6-20 by mass ratio.

A dentifrice composition according to [ 1 ], wherein the dentifrice composition contains 0.1 to 0.3% by mass of the component (C).

[ 3 ] A dentifrice composition according to [ 1 ] or [ 2 ], wherein the dentifrice composition further comprises (D) a thickening silica in an amount of 0.1 to 10% by mass.

A dentifrice composition according to any one of [ 1 ] to [ 3 ], wherein the dentifrice composition further comprises (E) a surfactant in an amount of 0.1 to 5% by mass.

[ 5 ] A dentifrice composition according to [ 4 ], wherein the surfactant (E) is an anionic surfactant having a sulfonic acid group.

A dentifrice composition according to any one of [ 1 ] to [ 5 ], wherein the content of the organic binder other than the components (B) and (C) is 0 to 0.5% by mass.

Effects of the invention

The present invention can provide a dentifrice composition which can provide a sustained and high feeling of cleanness in the oral cavity and which is excellent in usability.

Detailed Description

The present invention will be described in further detail below. The dentifrice composition of the present invention is characterized by containing (A) N- (4-cyanomethylphenyl) -2-isopropyl-5-methylcyclohexanecarboxamide, (B) xanthan gum and (C) at least 1 selected from sodium polyacrylate and sodium alginate, and the mass ratio of (B)/(C) is a specific ratio.

(A) N- (4-cyanomethylphenyl) -2-isopropyl-5-methylcyclohexanecarboxamide exerts an effect of imparting a clean feeling in the oral cavity.

(A) The amount of the component (B) is 0.00001 to 0.01% (mass%, the same applies hereinafter) of the total composition, preferably 0.0001 to 0.005%. When the amount is less than 0.00001%, the feeling of cleanness in the oral cavity is poor. If the content is more than 0.01%, the sense of incompatibility and the sense of irritation in the oral cavity may be increased.

(B) The mixing amount of the xanthan gum is 1.4-2.5%, preferably 1.6-2.0% of the whole composition. When the amount is less than 1.4%, the feeling of cleanness in the oral cavity is poor. When the content is more than 2.5%, the feeling of cleanness in the oral cavity is reduced.

(C) The component (A) is sodium polyacrylate or sodium alginate, and can be used alone or in combination from the viewpoint of the effect.

(C) The amount of the component (C) is preferably 0.1 to 0.3% of the total composition, although it is suitably set to (B)/(C) described below. At 0.1% or more, the ease of placement on a toothbrush is sufficiently good, and at 0.3% or less, the stringiness is sufficiently well maintained.

In the present invention, when the amount ratio of the components (B) and (C) is within a specific range, the ease of placement on a toothbrush is maintained well, and a sustained and excellent feeling of cleanliness in the oral cavity can be imparted.

In this case, (B)/(C) representing the mixing ratio of the component (B) and the component (C) is 6 to 20, preferably 6 to 15, and more preferably 6 to 10 in terms of mass ratio. (B) If the mass ratio of (C) is less than 6, the ease of placement on the toothbrush is poor, and if it exceeds 20, the ease of placement on the toothbrush is poor.

In the present invention, it is preferable to further mix (D) thickening silica as an inorganic binder. When (D) thickening silica is blended, deterioration of stringiness due to an increase in the content of (B) xanthan gum is further suppressed, and ease of placement on a toothbrush is further improved.

When the thickening silica is mixed (D), the mixing amount is preferably 0.1 to 10%, more preferably 0.5 to 8%, and further preferably 1 to 8% of the total composition. When too much mixing occurs, the ease of placement on a toothbrush may be poor.

In the present invention, the organic binders other than the components (B) and (C) (xanthan gum, sodium polyacrylate, and sodium alginate) may not be mixed, and the organic binders other than the components (B) and (C) may be mixed within a range not to impair the effects of the present invention.

Specifically, examples of the organic binder other than the components (B) and (C) include sodium carboxymethylcellulose, polyvinylpyrrolidone, carrageenan, methylcellulose, sodium hydroxyethylcellulose, tragacanth, karaya gum, acacia, locust bean gum, polyvinyl alcohol, carboxyvinyl polymer, carbomer (carbopol), and propylene glycol alginate. When these organic binders are mixed, the mixing amount is preferably 0.5% or less. Or not mixed, and may be 0%.

In the present invention, it is preferable to further mix (E) a surfactant, and when (E) a surfactant is mixed, the foaming property is moderately increased, and the feeling of cleanliness in the oral cavity is further improved.

As the (E) surfactant, an anionic surfactant is particularly preferable.

As the anionic surfactant, alkyl sulfate; an alpha-olefin sulfonate; hydrogenated coconut oil fatty acid monoglyceride monosulfate; lauryl alcohol sulfoacetate salts; n-acyl taurates such as N-methyl-N-acyl taurates; acyl amino acid salts such as acyl sarcosinate and N-acyl-L-glutamate. These may be used in 1 or 2 or more. Among these, anionic surfactants containing a sulfonic acid group are preferable from the viewpoint of good foamability and foam quality, and alkyl sulfates and α -olefin sulfonates are more preferable. The salt includes sodium salt, potassium salt, ammonium salt and the like, and sodium salt is particularly preferable.

The alkyl sulfate preferably has 12 to 14 carbon atoms in the alkyl group, and specific examples of the alkyl sulfate include sodium lauryl sulfate and sodium myristoyl sulfate.

As the alpha-olefin sulfonate, alkali metal salts of alpha-olefin sulfonic acid having 14 to 16 carbon atoms such as sodium and potassium can be used, among which alpha-olefin sulfonate having 14 carbon atoms is preferable, and sodium salt (common name; sodium tetradecene sulfonate) is particularly preferable. Commercially available products that can be used in the oral preparation are available, and for example, the product name "K LIPOLAN PJ-400 CJ" manufactured by Shiwang Special chemical Co., Ltd.

(E) The amount of the surfactant, particularly the anionic surfactant, is preferably 0.1 to 5%, more preferably 0.5 to 2.5%, and further preferably 1.0 to 2.0% of the total composition.

Further, a nonionic surfactant, an amphoteric surfactant, or the like may be mixed as the (E) surfactant in a range of 5% or less of the total composition. When an anionic surfactant and a surfactant other than anionic surfactants are used in combination and mixed, they are preferably used within a range not impairing the effect of the present invention, and the amount of the surfactant other than anionic surfactants is preferably 4.5% or less, particularly preferably 3% or less, of the total composition, and may be 0% or less without mixing.

The dentifrice composition of the present invention can be prepared in the form of a paste, a liquid or the like, and various forms such as a paste dentifrice, a liquid dentifrice, a tooth rinse (tooth-powder), and the like, and preferably, a paste dentifrice can be prepared by a conventional method. In addition to the above-mentioned components, generally, known components used in dentifrice compositions may be mixed as necessary within the range not impairing the effects of the present invention. Examples of the optional components that can be mixed include abrasives, humectants, sweeteners, preservatives, pH adjusters, flavors, and medicinal components.

Examples of the polishing agent include calcium phosphate-based polishing agents such as calcium monohydrogen phosphate dihydrate or anhydrous calcium monohydrogen phosphate, calcium dihydrogen phosphate, tricalcium phosphate, and calcium pyrophosphate; silica-based abrasives such as precipitated silica, aluminum silicate, zirconium silicate, titanium-bonded silica and the like; calcium carbonate-based abrasives such as calcium carbonate; calcium hydroxide, aluminum hydroxide, trimagnesium phosphate, magnesium carbonate, calcium sulfate, bentonite, and hydroxyapatite, and 1 or 2 or more of them may be used. Among them, silica-based abrasives and calcium carbonate-based abrasives containing a silicate such as precipitated silica, aluminum silicate, zirconium silicate and titanium-bonded silica as a main component are particularly preferable, and silica-based abrasives such as precipitated silica are particularly preferable.

The polishing agent, particularly precipitated silica, is preferably abrasive particles having a particle diameter of 1 to 40 μm, and further preferably a BET specific surface area of 80 to 250 square meters per 1 g. The particle diameter is a value measured by a particle size distribution measuring apparatus (Mackek particle size distribution meter, manufactured by Nikkiso K.K., dispersant; water).

Commercially available silica-based abrasives can be used, and examples thereof include Zeodent124 and Zeodent113 manufactured by HUBER corporation; TIXOSIL 73 and TIXOSIL 63 manufactured by Rhodia; sident 3, Sident 20 manufactured by Degussa; zirconium silicate and aluminum silicate manufactured by woodchemical corporation.

The abrasive may be in the form of particles, and the particles may be mixed as an abrasive component. The particles may be obtained by pulverizing silica gel to obtain granules, or by granulating a binder to obtain granules, in order to form water-insoluble powder into granules.

The amount of the abrasive to be mixed is 8 to 70%, particularly preferably 10 to 50% of the whole composition.

Examples of the humectant include sugar alcohols such as sorbitol and xylitol, and polyhydric alcohols such as propylene glycol and glycerin. The amount to be mixed is usually 5 to 50%, particularly preferably 20 to 45% of the whole composition.

Examples of the sweetener include saccharin sodium, stevioside, stevia extract, p-methoxycinnamaldehyde, neohesperidin dihydrochalcone, perillatin, glycyrrhizin, thaumatin, and aspartame.

Examples of the preservative include parabens and sodium benzoate.

Examples of the pH adjuster include organic acids such as citric acid and lactic acid, and salts thereof; inorganic compounds such as hydrochloric acid, sodium hydroxide, potassium hydroxide, disodium hydrogen phosphate, and sodium dihydrogen phosphate.

Examples of the flavor include known oral flavors such as menthol, anethole, carvone, eugenol, limonene, n-decanol, citronellol, α -terpineol, citronellyl acetate, eucalyptol, linalool, ethyl linalool, vanillin, thymol, spearmint oil, peppermint oil, lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, pimenta oil (pimenta oil), bay oil, perilla oil, wintergreen oil, clove oil, eucalyptus oil, and the like.

As the active ingredient, enzymes such as dextranase, amylase, protease, and dextran allosteric hydrolase; tranexamic acid, epsilon-aminocaproic acid, azulene, glycyrrhetate, glycyrrhetinate and other anti-inflammatory agents; cell activators such as sodium chloride, vitamins, allantoins, etc.; bactericides such as isopropyl methylphenol, cetylpyridinium chloride, benzalkonium chloride, hinokitiol (hinokitiol), lysozyme chloride, and the like; water-soluble copper compounds such as copper chlorophyll and copper gluconate; dental calculus preventives such as zeolite; blood circulation-promoting agents such as vitamin E; amino acids such as alanine, glycine and proline. The amount of the active ingredient to be mixed may be an effective amount within a range not to impair the effect of the present invention.

Further, as an arbitrary component, an inorganic compound such as mica titanium, titanium oxide, bentonite, etc. may be mixed in a range not to impair the effects of the present invention; cellulose-based organic powders such as microcrystalline cellulose; natural high molecular compounds such as agar, gelatin, starch, glucomannan, etc.; synthetic high molecular compounds such as polyvinyl acetate, acrylic resin, polyurethane, polyester, polyvinyl chloride, nylon powder, polyethylene powder, and copolymers thereof; waxes such as carnauba wax, rosin, rice bran wax, microcrystalline wax, beeswax, and paraffin wax; higher alcohols such as cetyl alcohol and stearyl alcohol; polyisobutylene, polybutadiene, silicone, natural rubber, and the like.

[ examples ] A method for producing a compound

The present invention will be described in more detail with reference to examples and comparative examples, but the present invention is not limited to the examples. In the following examples,% represents% by mass unless otherwise specified.

[ examples and comparative examples ]

Dentifrice compositions (dentifrice creams) having the compositions shown in tables 1 to 3 were prepared by a usual method and filled into a usual laminate tube container. The obtained dentifrice composition was used as a sample and evaluated by the following method. The results are shown in tables 1 to 3.

Evaluation method

Evaluation was performed by 4 subjects.

1g of the dentifrice composition as a sample was put on a toothbrush (CLINICA ADVANTAGE toothbrush, 4-line compact conventional model, manufactured by lion king corporation) and tooth brushing was performed for 3 minutes.

With respect to the feeling of cleanness in the oral cavity, the feeling of cleanness in the oral cavity immediately after the mouth was rinsed and after 30 minutes had passed after the mouth was rinsed was judged by the following scoring standards. Here, the feeling of cleanness in the oral cavity means a refreshing feeling in which stains are removed from the oral cavity.

The oral incompatibility (bad taste, incompatibility due to stimulus) during brushing was judged by the following scoring criteria.

With respect to ease of placement on a toothbrush, ease of placement when the sample was extruded onto the toothbrush in a tube container was judged by the following scoring criteria. Judging whether the wire is drawn or not according to the physical properties of the sample; if the sample had too high a shape retention to fall off the toothbrush, a dentifrice composition without such a condition was judged to be easy to set.

The average values were obtained, and the results of the determinations were evaluated according to the evaluation criteria shown below.

< feeling of cleanness in oral cavity (immediately after rinsing mouth, after 30 minutes after rinsing mouth) >

Scoring criteria

5: feeling strong

4: feel to

3: slightly feel

2: whether or not to say inaccurately

1: can not feel

Evaluation criteria

Very good: the average score of 4 people is more than 4

O: the average score of 4 persons is more than 3 and less than 4

And (delta): the average score of 4 persons is more than 2 and less than 3

X: average score of 4 persons is less than 2

< feeling of incompatibility in oral cavity >

Scoring criteria

5: can not feel

4: whether or not to say inaccurately

3: slightly feel

2: feel to

1: strongly feel

Evaluation criteria

Very good: the average score of 4 persons is more than 4.5

O: the average score of 4 persons is more than 4 and less than 4.5

And (delta): the average score of 4 persons is more than 2 and less than 4

X: average score of 4 persons is less than 2

< ease of placing on toothbrush >

Scoring criteria

5: is very easy to put

4: is easy to put

3: whether or not it is too inaccurate to speak

2: difficult to release

1: is very difficult to put

Evaluation criteria

Very good: the average score of 4 people is more than 4

O: the average score of 4 persons is more than 3 and less than 4

And (delta): the average score of 4 persons is more than 2 and less than 3

X: average score of 4 persons is less than 2

Details of the raw materials used are as follows.

(A) N- (4-cyanomethylphenyl) -2-isopropyl-5-methylcyclohexanecarboxamide: ever Cool180 (manufactured by Kyoton Japan K.K.)

Menthyl lactate (comparative): frescolat ML (manufactured by De Zhi Xin Co., Ltd.)

N-ethyl-p-menthane carboxamide (comparative): WS-3 (registered trademark, manufactured by Kyoton Japan K.K.)

(B) Xanthan gum: monat Gum DA (manufactured by Sbikaiko Co., Ltd.)

(C) Sodium polyacrylate: RHEOGIC 260H (manufactured by Toyo Synthesis Co., Ltd.)

(C) Sodium alginate: KIMICA ALGIN (KIMICA corporation, Kyowa)

Sodium carboxymethylcellulose (comparative): CMC1260 (manufactured by Daicel FineChem corporation)

Polyvinylpyrrolidone (comparative): luviskol K30(BASF corporation)

(D) Thickening silica: cardlex #67 (manufactured by DSL Japan Co., Ltd.)

(E) Sodium lauryl sulfate: texapon (manufactured by BASF corporation)

[ TABLE 1 ]

[ TABLE 2 ]

[ TABLE 3 ]

Claims (6)

1. A dentifrice composition comprising

0.00001 to 0.01 mass% of (A) N- (4-cyanomethylphenyl) -2-isopropyl-5-methylcyclohexanecarboxamide,

1.4 to 2.5 mass% of (B) xanthan gum, and

(C) more than 1 selected from sodium polyacrylate and sodium alginate,

and (B)/(C) is 6-20 by mass ratio.

2. A dentifrice composition according to claim 1, wherein the dentifrice composition contains 0.1 to 0.3% by mass of the component (C).

3. The dentifrice composition according to claim 1 or 2, wherein the dentifrice composition further comprises (D) thickening silica in an amount of 0.1 to 10% by mass.

4. A dentifrice composition according to any one of claims 1 to 3, further comprising (E) a surfactant in an amount of 0.1 to 5% by mass.

5. The dentifrice composition according to claim 4, wherein the (E) surfactant is an anionic surfactant having a sulfonic acid group.

6. A dentifrice composition as claimed in any one of claims 1 to 5 wherein the content of the organic binder other than the components (B) and (C) is 0 to 0.5% by mass.