CN110496083A - A kind of mulberry bark extract and using it as the hair restorer of effective component - Google Patents
A kind of mulberry bark extract and using it as the hair restorer of effective component Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
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Abstract
The present invention relates to a kind of mulberry bark extract and using it as the hair restorer of effective component, the mulberry bark extract the preparation method comprises the following steps: (1) crushes the root bark of white mulberry, be added in hydrophilic organic solvent or its aqueous solution and extract after crushing；(2) extracting solution is concentrated, solvent is distilled off；(3) it is extracted again with oleophilic organic solvent；(4) organic solvent is mutually fractionated to acquisition, is dried after solvent is distilled off to get the mulberry bark extract.The hair restorer the preparation method comprises the following steps: mulberry bark extract is dissolved in hydrous ethanol or camellia caul-fat to obtain the final product.The baldness such as male pattern baldness, alopecia generalisata disease can be prevented and treated by hair restorer prepared by effective component of mulberry bark extract, hair cycles transfer capability with height, stand-down hair is allowed to turn to the ability of growth stage hair, significant hair-growing effects can be played, and use safe and non-toxic.
Description
Technical field
The invention belongs to daily cosmetics fields, and in particular to a kind of mulberry bark extract and using it as the life of effective component
Send out agent.
Background technique
Baldness is according to its reason and symptom come point, and there are many kinds of classes, but main Types have male pattern baldness, diffuse
Property baldness and round baldness.Wherein, round baldness is momentary symptom, is treated in dermatology field, is fully recovered
Example it is very much.But the above two have it is intractable.Wherein, male pattern baldness has very strong heredity will be because；Mention its at
Cause has male hormones opinion, peripheral circulation disorders opinion；As for the factor of other non-principal reasons, there are parasteatosis, dandruff
Excessively, malnutritive opinion etc..In addition, women alopecia generalisata disease, there is hair follicle poor blood circulation in the reason of being mentioned, because of hair washing
With excessively hair nursing etc. caused by comb hair etc..
In previous hair restorer, for above-mentioned reason, following ingredients have been used.To improve peripheral circulation, Japan is used
Herba Swertiae bimaculatae extract, garlic P.E, carpronium chloride, ginger-root extract, millet starch berry extract, vitamin e；To improve sebum
Diacrisis uses vitamin B6 and its derivative；It is excessive to improve dandruff, use isopropyl-phenol, Hinokitiol, salicylic acid；
Use glycyrrhizic acid, Hinokitiol, chlorination diphenhydramine as antiphlogistic；Use photosensitive plain 301, Hinokitiol, placental hormone, pentadecane acid
Monoglyceride etc. is used as cell activity agent.However, although these ingredients, have the improvement of respective symptom certain
Effect, it can not but improve alopecia state.In addition, since male pattern baldness its illness producing cause has with male hormones
It closes, therefore without using male hormones then uses the women close with its property in the product for the treatment of male pattern baldness
Hormone.But it will appear side effect in this way, so content cannot add too much, to be difficult to ensure its validity, and then up to not
To expected effect.
Therefore, at this stage, for male pattern baldness and chronic baldness, it is not yet clear that the method for its basic improvement.
But alopecia is because the proliferation of hair follicle cell is suppressed, in the growth stage, (hair was in the period of growth, normally originally
Human hair has 90% or more in the growth stage) hair transfer to enter stand-down (hair stops growing, the period of trichomadesis,
There is 10% hair be in this period in normal human hair), then we can from the substance for promoting hair follicle cell proliferation or
Set about in terms of the hair in stand-down can be allowed to turn to the substance of growth stage hair, is possible to obtain effective hair restorer in this way.
Summary of the invention
The technical problem to be solved by the invention is to provide a kind of mulberry bark extract and using it as the hair tonic of effective component
Agent, the hair restorer as made from the mulberry bark extract have the hair cycles transfer capability of height, have the effect of hair tonic.
Above-mentioned technical problem to be solved by this invention, is achieved by following technical solution:
A kind of preparation method of mulberry bark extract, the preparation of the mulberry bark extract comprise the following steps:
(1) root bark of white mulberry is crushed, is added in hydrophilic organic solvent or its aqueous solution and extracts after crushing；
(2) extracting solution is concentrated, solvent is distilled off；
(3) it is extracted again with oleophilic organic solvent；
(4) organic solvent is mutually fractionated to acquisition, is dried after solvent is distilled off to get the mulberry bark extract.
As a preferred embodiment, the root bark of white mulberry is Zhen Sang or the root skin of other congeners in the step (1).
As a preferred embodiment, the hydrophilic organic solvent in the step (1) is methanol, ethyl alcohol, one in acetone
Kind.
As a preferred embodiment, the extracting method in the step (1) are as follows: the concentration ratio control of hydrophilic organic solvent
For system 30% or more, the additive amount of Extraction solvent is 5 ~ 15 times of the root bark of white mulberry, stands 3 days or more under heating or room temperature under circulation.
As a preferred embodiment, the extracting method in the step (1) are as follows: the concentration ratio control of hydrophilic organic solvent
For system 70% or more, the additive amount of Extraction solvent is 10 ~ 15 times of the root bark of white mulberry, under heating or room temperature stand 7 days under circulation with
On.
As a preferred embodiment, the oleophilic organic solvent in the step (3) is ethyl acetate, diethyl ether, benzene, first
One of benzene, dimethylbenzene.
As a preferred embodiment, the extracting method in the step (3) are as follows: the additive amount of oleophilic organic solvent is mulberry
0.1 ~ 3 times of white skin raw material, after addition, stirring is stood.
As a preferred embodiment, the extracting method in the step (3) are as follows: the additive amount of oleophilic organic solvent is mulberry
0.2 ~ 1 times of white skin raw material, after addition, stirring is stood.
The present invention also provides a kind of hair restorer, the effective component of the hair restorer is that the above-mentioned obtained root bark of white mulberry extracts
Object, additive amount are 0.001 ~ 5 weight percent.
As a preferred embodiment, the preparation method of the hair restorer be by mulberry bark extract be dissolved in hydrous ethanol or
In camellia caul-fat to obtain the final product.
The utility model has the advantages that (1) mulberry bark extract of the present invention only needs to obtain by second extraction, operation can
Row is strong；(2) hair restorer of the mulberry bark extract preparation obtained by the present invention can prevent and treat male pattern baldness, more
The baldness such as unrestrained property baldness；(3) the made hair restorer of the present invention has the hair cycles transfer capability of height, that is, allows stand-down mao
Hair turns to the ability of growth stage hair, can play significant hair-growing effects, and use safe and non-toxic.
Specific embodiment
It in order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below will be in the embodiment of the present invention
Technical solution be clearly and completely described, it is clear that described embodiments are some of the embodiments of the present invention, rather than
Whole embodiments.Based on the embodiments of the present invention, those of ordinary skill in the art are not making creative work premise
Under every other embodiment obtained, shall fall within the protection scope of the present invention.
Embodiment 1
A kind of preparation method of mulberry bark extract
The mulberry bark extract is the preparation method comprises the following steps: the 500g root bark of white mulberry shredded is added in 5 liters of 70% ethyl alcohol, at room temperature
It impregnates 7 days, extracts 70% ethyl alcohol solubilizing component, obtain 4.4 liters of extracting solution, then, the ethanol distillation in extracting solution is removed, it will
After liquid measure is set to 500ml, the oleophilic organic solvent diethyl ether of 500ml is added, stirring is stood after 15 minutes, by diethyl ether phase
Fractionation obtains.The diethyl ether for the diethyl ether Xiangli that will acquire distills removal, then dries to get mulberry bark extract.
The preparation method of hair restorer
The hair restorer is added in 1 liter 70% of ethyl alcohol and is dissolved the preparation method comprises the following steps: take above-mentioned made mulberry bark extract 7.0g
Afterwards, it places shady place 3 days, then filters to get the hair restorer.
Embodiment 2
A kind of preparation method of mulberry bark extract
The mulberry bark extract is the preparation method comprises the following steps: together by the root bark of white mulberry of 500g chopping and 5 liter 70% of methanol, at room temperature
It impregnates 7 days.Extract 70% methanol solubilizing component.Then, by after the methanol distillation removal in extracting solution, 500ml is added water to inward,
Then add 500ml oleophilic organic solvent ethyl acetate inward again, stirring is stood after 15 minutes, and ethyl acetate phase is extracted in fractionation.
After the ethyl acetate distillation removal for the ethyl acetate Xiangli that will acquire, it is dried to get mulberry bark extract.
The preparation method of hair restorer
The hair restorer is the preparation method comprises the following steps: take above-mentioned made mulberry bark extract 7g, after being dissolved in 1 liter of 70% ethyl alcohol, in cool place
Place is placed 3 days, is then filtered to get the hair restorer.
Embodiment 3
A kind of preparation method of mulberry bark extract
The mulberry bark extract is the preparation method comprises the following steps: together by the root bark of white mulberry of 500g chopping and 5 liter 70% of acetone, at room temperature
It impregnates 3 days.70% acetone solubilizing component is extracted, 4.5 liters of extracting solutions are obtained.Then, the acetone in extracting solution is distilled into removal, it will
After liquid measure is set to 500ml, 500ml oleophilic organic solvent toluene is added, stirring stands after 15 minutes, toluene is mutually fractionated and is mentioned
It takes.It is dried after the toluene distillation of obtained toluene Xiangli is removed to get mulberry bark extract.
The preparation method of hair restorer
The hair restorer is the preparation method comprises the following steps: take above-mentioned made mulberry bark extract 7g, after being dissolved in 1 liter of 70% ethyl alcohol, shady place
It places 3 days, then filters to get the hair restorer.
Embodiment 4
A kind of preparation method of mulberry bark extract
The mulberry bark extract is the preparation method comprises the following steps: the 500g root bark of white mulberry shredded is added in 5 liters of 70% ethyl alcohol, heating ring
Stream 2 minutes extracts 70% ethyl alcohol solubilizing component, obtains 4.4 liters of extracting solution, and then, the ethanol distillation in extracting solution is removed, will
After liquid measure is set to 500ml, the oleophilic organic solvent diethyl ether of 500ml is added, stirring is stood after 15 minutes, by diethyl ether phase
Fractionation obtains.The diethyl ether for the diethyl ether Xiangli that will acquire distills removal, then dries to get mulberry bark extract.
The preparation method of hair restorer
The hair restorer is added in 1 liter 70% of ethyl alcohol and is dissolved the preparation method comprises the following steps: take above-mentioned made mulberry bark extract 7.0g
Afterwards, it places shady place 3 days, then filters to get the hair restorer.
Embodiment 5
A kind of preparation method of mulberry bark extract
The mulberry bark extract is the preparation method comprises the following steps: the 500g root bark of white mulberry shredded is added in 5 liters of 90% ethyl alcohol, at room temperature
It impregnates 7 days, extracts 90% ethyl alcohol solubilizing component, obtain 4.4 liters of extracting solution, then, the ethanol distillation in extracting solution is removed, it will
After liquid measure is set to 500ml, the oleophilic organic solvent diethyl ether of 500ml is added, stirring is stood after 15 minutes, by diethyl ether phase
Fractionation obtains.The diethyl ether for the diethyl ether Xiangli that will acquire distills removal, then dries to get mulberry bark extract.
The preparation method of hair restorer
The hair restorer is added in 1 liter 90% of ethyl alcohol and is dissolved the preparation method comprises the following steps: take above-mentioned made mulberry bark extract 7.0g
Afterwards, it places shady place 3 days, then filters to get the hair restorer.
Embodiment 6
A kind of preparation method of mulberry bark extract
The mulberry bark extract is the preparation method comprises the following steps: the 500g root bark of white mulberry shredded is added in 5 liters of 70% ethyl alcohol, at room temperature
It impregnates 7 days, extracts 70% ethyl alcohol solubilizing component, obtain 4.4 liters of extracting solution, then, the ethanol distillation in extracting solution is removed, it will
After liquid measure is set to 500ml, the oleophilic organic solvent diethyl ether of 500ml is added, stirring is stood after 15 minutes, by diethyl ether phase
Fractionation obtains.The diethyl ether for the diethyl ether Xiangli that will acquire distills removal, then dries to get mulberry bark extract.
The preparation method of hair restorer
The hair restorer is added in 1 kilogram of camellia caul-fat and is dissolved the preparation method comprises the following steps: take above-mentioned made mulberry bark extract 7.0g
Afterwards, it places shady place 3 days, then filters to get the hair restorer.
Comparative example 1
1 difference from Example 1 of comparative example is that 1 hydrophilic organic solvent of comparative example is dioxane, lipophilic organic molten
Agent is n-butanol, other all identical.
Comparative example 2
2 difference from Example 1 of comparative example is that 2 hydrophilic organic solvent of comparative example is isopropanol, oleophilic organic solvent
It is other all identical for butyl acetate.
Comparative example 3
A kind of preparation method of mulberry bark extract
The mulberry bark extract is the preparation method comprises the following steps: the 500g root bark of white mulberry shredded is added in 5 liters of 70% ethyl alcohol, at room temperature
It impregnates 7 days, extracts 70% ethyl alcohol solubilizing component, obtain 4.4 liters of extracting solution, then, the ethanol distillation in extracting solution is removed, then
It is dried to get mulberry bark extract.
The preparation method of hair restorer
The hair restorer is added in 1 liter 70% of ethyl alcohol and is dissolved the preparation method comprises the following steps: take above-mentioned made mulberry bark extract 7.0g
Afterwards, it places shady place 3 days, then filters to get the hair restorer.
Comparative example 4
A kind of preparation method of mulberry bark extract
The mulberry bark extract is soaked at room temperature the preparation method comprises the following steps: the 500g root bark of white mulberry shredded is added in 5 liters of diethyl ether
Bubble 7 days, is then filtered, then be fractionated to obtain diethyl ether phase, and the diethyl ether for the diethyl ether Xiangli that will acquire distills removal, is then done
It is dry to get mulberry bark extract.
The preparation method of hair restorer
The hair restorer is added in 1 liter 70% of ethyl alcohol and is dissolved the preparation method comprises the following steps: take above-mentioned made mulberry bark extract 7.0g
Afterwards, it places shady place 3 days, then filters to get the hair restorer.
In order to further prove effect of the invention, following test method is provided:
1. the time that hair is changed into the growth stage from growth period: the back wool of 24 weeks rabbits (New Zealand White rabbit) after birth
Hair, entirely stand-down hair, it is good male pattern baldness, a chronic baldness that stand-down hair ratio is high
Animal disorders model coats the medicament with hair-growing effects in this period, if the chaeta of only medicament spreader portion becomes into
For a long time, hair starts to extend, then thus can clearly judge the effect of hair tonic.That is, allowing the stopping of this rabbit
Phase hair turns to the medicament of growth stage hair, has effective clinical effectiveness to male pattern baldness, chronic baldness.
Specific operation process: the hair at the rabbit back of 20 ~ 21 week old is shaved off with electric clippers, later, it is thus identified that the portion
The chaeta of position does not extend, that is to say, that, it is thus identified that the position chaeta becomes stand-down from the growth stage.By back chaeta just from
Growth stage switchs to the rabbit of stand-down, selects 6 to be only used as 1 group, and their own back shaving position is divided into multiple zonules,
Each zonule is 4 square centimeters of quadrangle.Toward their back shaving positions central part with by test medicine with 1 day 1
The secondary frequency smears 0.2ml.This is operated, and is up to the chaeta at the back shaving position without any chemicals treatment becomes the growth stage
Only, experiment just stops.
Shortening and its hair tonic state during until switching to the growth stage from stand-down by the chaeta of experiment position is carried out
Evaluation.As a result table 1 is seen.In addition, evaluation criteria is as follows.Firstly, during until switching to the growth stage from stand-down
Shortening situation, by following 3 Phase Evaluations.
Significant effect: and non-treated regional correlation, shorten 4 weeks or more；It is effective: and non-treated regional correlation, shorten 2 ~ 4
Week；It is invalid: and non-treated regional correlation, shorten 2 weeks additionally below, to hair tonic state, according to following 4 Phase Evaluations: +++:
Chaeta flourishes significantly；++: chaeta flourishes clear；+: slightly there is hair tonic/educate hair effect；: absolutely not hair tonic/educate
Send out effect.
1 hair tonic state evaluation of table
According to the above results it is found that embodiment 1 ~ 6 has significant effect, the time for switching to the growth stage from stand-down compares no treatment area
Shorten 5 weeks in domain；Comparative example 1,2 more non-treated regions shorten 3 weeks and effective；Comparative example 3,4 and commercially available hair restorer are invalid.Separately
Outside, comparative example 1,2 more non-treated regions shorten 3 weeks and effective；Furthermore case study on implementation 1 ~ 6 of the invention is compared to comparison case
Example 1,2, have more rapidly, significant hair-growing effects, only with the comparison case 4 of 1 Extraction solvent extraction, though have a degree of
Hair-growing effects；But the method for carrying out 2 extractions using hydrophily, lipophilic Extraction solvent, has more significant hair-growing effects.
2. the improvement of pair male pattern baldness patient's alopecia state is tested: the hair tonic that will be mentioned in embodiment 1
Agent, the male pattern baldness patient for allowing 23 38 ~ 60 years old ages not wait use daily, and continuous 6 months, also, on head
External application number is set to 1 day 2 times；With the hair tonic state after 6 months after observation 3 months, evaluated by 4 following stages.
As a result table 2 is seen.+++: visible new setation (bristle)；++: visible new setation (fur)；+: hair loss is reduced；: entirely without
Variation, test result are shown in Table 2.
Using effect of the table 2 for male pattern baldness
As can be seen from Table 2, after 3 months, hairiness grows if there is the alopecia position of 10 patients in 23 patients；After 6 months,
There are 8 to grow bristle in 23 patients, 6 grow fur, and remaining 9 hair loss are reduced；Above data explanation uses the hair tonic
Agent has 61% patient is visible to have new setation, this presents very good alopecia improvement does not have during testing use
It was found that there is the case where any scalp state deteriorating.
3. the improvement of pair alopecia generalisata disease patient's alopecia state is tested: the hair tonic that will be mentioned in embodiment 1
Agent, the alopecia generalisata disease patient for allowing 16 35 ~ 63 years old ages not wait use daily, and continuous 6 months, also, on head
External application number is set to after 1 day 2 times observations 3 months and the hair tonic state after 6 months, is evaluated by 4 following stages.Knot
Fruit sees table 3.+++: visible new setation (bristle)；++: visible new setation (fur)；+: hair loss is reduced；: entirely without change
Change, test result is shown in Table 3.
Using effect of the table 3 for alopecia generalisata disease
As seen from Table 3, if there is 6 patient's alopecia positions to there is hairiness to grow in 16 patients；After 6 months, in 16 patients
There are 6 to grow bristle, 4 grow fur, and remaining 6 hair loss are reduced.Above data explanation has 63% patient is visible to have newly
Setation is grown, this presents extremely good alopecia improvement.In addition, not found any head during testing use
The case where skin state deteriorating.
Hair restorer of the invention can significantly shorten the stand-down in the chaeta period of rabbit (New Zealand's white race), and
And clinical use test has been carried out to human body, also show that apparent hair-growing effects.In addition, hair restorer of the invention, using day
The right root bark of white mulberry is raw material, so and the excellent product of a safety.Therefore it can be concluded that, hair restorer of the invention is right
In baldness such as male pattern baldness, alopecia generalisata diseases, there is effective treatment and prevention effect.
The basic principles, main features and advantages of the present invention have been shown and described above.The technology of the industry
Personnel are it should be appreciated that the present invention is not limited to the above embodiments, and what is described in the above embodiment and the description is only the present invention
Principle, various changes and improvements may be made to the invention without departing from the spirit and scope of the present invention, these variation and
Improvement is both fallen in the range of claimed invention.The present invention claims protection scope by appended claims and its
Equivalent defines.
Claims (10)
1. a kind of mulberry bark extract, which is characterized in that the mulberry bark extract the preparation method comprises the following steps:
(1) root bark of white mulberry is crushed, is added in hydrophilic organic solvent or its aqueous solution and extracts after crushing；
(2) extracting solution is concentrated, solvent is distilled off；
(3) it is extracted again with oleophilic organic solvent；
(4) organic solvent is mutually fractionated to acquisition, is dried after solvent is distilled off to get the mulberry bark extract.
2. mulberry bark extract preparation method according to claim 1, which is characterized in that the root bark of white mulberry in the step (1)
For the root skin of Zhen Sang or other congeners.
3. mulberry bark extract preparation method according to claim 1, which is characterized in that hydrophilic in the step (1)
Property organic solvent be one of methanol, ethyl alcohol, acetone.
4. mulberry bark extract preparation method according to claim 1, which is characterized in that the extraction in the step (1)
Method are as follows: 30% or more, the additive amount of Extraction solvent is the 5 ~ 15 of the root bark of white mulberry for the concentration ratio control of hydrophilic organic solvent
Times, 3 days or more are stood under heating or room temperature under circulation.
5. mulberry bark extract preparation method according to claim 1, which is characterized in that the extraction in the step (1)
Method are as follows: 70% or more, the additive amount of Extraction solvent is the 10 ~ 15 of the root bark of white mulberry for the concentration ratio control of hydrophilic organic solvent
Times, 7 days or more are stood under heating or room temperature under circulation.
6. mulberry bark extract preparation method according to claim 1, which is characterized in that the oleophylic in the step (3)
Property organic solvent be one of ethyl acetate, diethyl ether, benzene,toluene,xylene.
7. mulberry bark extract preparation method according to claim 1, which is characterized in that the extraction in the step (3)
Method are as follows: the additive amount of oleophilic organic solvent is 0.1 ~ 3 times of root bark of white mulberry raw material, and after addition, stirring is stood.
8. mulberry bark extract preparation method according to claim 1, which is characterized in that the extraction in the step (3)
Method are as follows: the additive amount of oleophilic organic solvent is 0.2 ~ 1 times of root bark of white mulberry raw material, and after addition, stirring is stood.
9. a kind of hair restorer, which is characterized in that the effective component of the hair restorer is that any root bark of white mulberry of claim 1 ~ 8 mentions
The mulberry bark extract for taking object preparation method to prepare, additive amount are 0.001 ~ 5 weight percent.
10. hair restorer according to claim 9, which is characterized in that the preparation method of the hair restorer is to mention the root bark of white mulberry
Take object to be dissolved in hydrous ethanol or camellia caul-fat to obtain the final product.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115554380A (en) * | 2022-06-13 | 2023-01-03 | 浩溪(海南)生物科技有限公司 | Composition for preventing and treating alopecia by acting on hair follicle tissues and application thereof |
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| CN1562173A (en) * | 2004-03-25 | 2005-01-12 | 沈阳药科大学 | Technique for producing extract product of mulberry bark |
| CN108272700A (en) * | 2018-04-18 | 2018-07-13 | 滕建芬 | A kind of composition and preparation method thereof with hair-loss preventing and hair-restoring, anti-dandruff and itching-relieving efficacies |
| CN110075049A (en) * | 2019-06-06 | 2019-08-02 | 广州环亚化妆品科技有限公司 | A kind of Chinese medical extract and its preparation method and application |
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| JPH06329517A (en) * | 1993-05-20 | 1994-11-29 | Fuji Sangyo Kk | Hair-raising agent |
| US5674497A (en) * | 1994-06-01 | 1997-10-07 | Fuji Sangyo Co., Ltd. | Hair growth promoter comprising extract of mulberry root bark and persimmon and/or paulownia, or extract of persimmon and paulownia |
| CN1562173A (en) * | 2004-03-25 | 2005-01-12 | 沈阳药科大学 | Technique for producing extract product of mulberry bark |
| CN108272700A (en) * | 2018-04-18 | 2018-07-13 | 滕建芬 | A kind of composition and preparation method thereof with hair-loss preventing and hair-restoring, anti-dandruff and itching-relieving efficacies |
| CN110075049A (en) * | 2019-06-06 | 2019-08-02 | 广州环亚化妆品科技有限公司 | A kind of Chinese medical extract and its preparation method and application |
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| CN115554380A (en) * | 2022-06-13 | 2023-01-03 | 浩溪(海南)生物科技有限公司 | Composition for preventing and treating alopecia by acting on hair follicle tissues and application thereof |
| CN115554380B (en) * | 2022-06-13 | 2023-09-26 | 浩溪(海南)生物科技有限公司 | Composition for preventing and treating alopecia by acting on hair follicle tissue and application thereof |
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