CN110408573A - 一种鼠李糖乳杆菌yfi-6及其在抗大鲵虹彩病毒中的应用 - Google Patents
一种鼠李糖乳杆菌yfi-6及其在抗大鲵虹彩病毒中的应用 Download PDFInfo
- Publication number
- CN110408573A CN110408573A CN201910765613.7A CN201910765613A CN110408573A CN 110408573 A CN110408573 A CN 110408573A CN 201910765613 A CN201910765613 A CN 201910765613A CN 110408573 A CN110408573 A CN 110408573A
- Authority
- CN
- China
- Prior art keywords
- lactobacillus rhamnosus
- yfi
- giant salamander
- gsiv
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000218588 Lactobacillus rhamnosus Species 0.000 title claims abstract description 58
- 241000701372 Iridovirus Species 0.000 title claims abstract description 18
- 241000269333 Caudata Species 0.000 title abstract description 11
- 230000003612 virological effect Effects 0.000 claims abstract description 9
- 241000157862 Dicamptodontidae Species 0.000 claims abstract 6
- 201000010099 disease Diseases 0.000 claims description 15
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 15
- 239000003814 drug Substances 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 3
- 235000019730 animal feed additive Nutrition 0.000 claims description 2
- 230000002155 anti-virotic effect Effects 0.000 claims description 2
- 230000002008 hemorrhagic effect Effects 0.000 claims 1
- 239000006228 supernatant Substances 0.000 abstract description 29
- 239000012530 fluid Substances 0.000 abstract description 26
- 230000000840 anti-viral effect Effects 0.000 abstract description 11
- 230000000694 effects Effects 0.000 abstract description 9
- 208000015181 infectious disease Diseases 0.000 abstract description 9
- 239000006041 probiotic Substances 0.000 abstract description 5
- 235000018291 probiotics Nutrition 0.000 abstract description 5
- 239000000047 product Substances 0.000 abstract description 3
- 231100000433 cytotoxic Toxicity 0.000 abstract description 2
- 230000001472 cytotoxic effect Effects 0.000 abstract description 2
- 208000031169 hemorrhagic disease Diseases 0.000 abstract description 2
- 231100000572 poisoning Toxicity 0.000 abstract 1
- 230000000607 poisoning effect Effects 0.000 abstract 1
- 241001415306 Cryptobranchidae Species 0.000 description 39
- 210000004027 cell Anatomy 0.000 description 30
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 20
- 241000894006 Bacteria Species 0.000 description 18
- 230000001580 bacterial effect Effects 0.000 description 15
- 241000700605 Viruses Species 0.000 description 13
- 235000014655 lactic acid Nutrition 0.000 description 10
- 239000004310 lactic acid Substances 0.000 description 10
- 239000007788 liquid Substances 0.000 description 10
- 239000002609 medium Substances 0.000 description 10
- 238000005259 measurement Methods 0.000 description 9
- 239000002356 single layer Substances 0.000 description 9
- 230000002401 inhibitory effect Effects 0.000 description 8
- 238000012423 maintenance Methods 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- 241000186660 Lactobacillus Species 0.000 description 7
- 238000009360 aquaculture Methods 0.000 description 7
- 238000010790 dilution Methods 0.000 description 7
- 239000012895 dilution Substances 0.000 description 7
- 229940039696 lactobacillus Drugs 0.000 description 7
- 210000002966 serum Anatomy 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 241001253208 Andrias davidianus Species 0.000 description 6
- 244000144974 aquaculture Species 0.000 description 6
- 241000251468 Actinopterygii Species 0.000 description 5
- 102000016943 Muramidase Human genes 0.000 description 5
- 108010014251 Muramidase Proteins 0.000 description 5
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 5
- 230000012010 growth Effects 0.000 description 5
- 238000011081 inoculation Methods 0.000 description 5
- 235000010335 lysozyme Nutrition 0.000 description 5
- 239000004325 lysozyme Substances 0.000 description 5
- 229960000274 lysozyme Drugs 0.000 description 5
- 102000016918 Complement C3 Human genes 0.000 description 4
- 108010028780 Complement C3 Proteins 0.000 description 4
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 description 4
- SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical compound C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 description 4
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 description 4
- 230000037396 body weight Effects 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- 238000000855 fermentation Methods 0.000 description 4
- 230000004151 fermentation Effects 0.000 description 4
- 239000001963 growth medium Substances 0.000 description 4
- 238000004321 preservation Methods 0.000 description 4
- 238000012545 processing Methods 0.000 description 4
- 230000019254 respiratory burst Effects 0.000 description 4
- 241001315730 Cyprinid herpesvirus 2 Species 0.000 description 3
- 241000252233 Cyprinus carpio Species 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 3
- 241000609060 Grass carp reovirus Species 0.000 description 3
- 208000032843 Hemorrhage Diseases 0.000 description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 230000000740 bleeding effect Effects 0.000 description 3
- 238000003501 co-culture Methods 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 238000011534 incubation Methods 0.000 description 3
- 239000008101 lactose Substances 0.000 description 3
- 150000002772 monosaccharides Chemical class 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 108020004465 16S ribosomal RNA Proteins 0.000 description 2
- 241000269328 Amphibia Species 0.000 description 2
- 201000009030 Carcinoma Diseases 0.000 description 2
- 206010059866 Drug resistance Diseases 0.000 description 2
- 241000701377 Iridoviridae Species 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 241000701382 Ranavirus Species 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 239000013553 cell monolayer Substances 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 208000010932 epithelial neoplasm Diseases 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 238000005374 membrane filtration Methods 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 230000004224 protection Effects 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 230000003716 rejuvenation Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 241001148471 unidentified anaerobic bacterium Species 0.000 description 2
- 229960005486 vaccine Drugs 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 241001253206 Andrias Species 0.000 description 1
- 208000031295 Animal disease Diseases 0.000 description 1
- 241001609213 Carassius carassius Species 0.000 description 1
- 238000008642 Complement C3 Assay Methods 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 241000709687 Coxsackievirus Species 0.000 description 1
- 241000252230 Ctenopharyngodon idella Species 0.000 description 1
- 241000276435 Gadus Species 0.000 description 1
- 241000175212 Herpesvirales Species 0.000 description 1
- 244000199866 Lactobacillus casei Species 0.000 description 1
- 235000013958 Lactobacillus casei Nutrition 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 231100000645 Reed–Muench method Toxicity 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 241000607598 Vibrio Species 0.000 description 1
- 241000544286 Vibrio anguillarum Species 0.000 description 1
- 206010058874 Viraemia Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000005013 brain tissue Anatomy 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000019771 cognition Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 210000004405 cytokine-induced killer cell Anatomy 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000006806 disease prevention Effects 0.000 description 1
- 238000002224 dissection Methods 0.000 description 1
- 239000003640 drug residue Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000008799 immune stress Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000001524 infective effect Effects 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000003292 kidney cell Anatomy 0.000 description 1
- 229940017800 lactobacillus casei Drugs 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 208000014987 limb edema Diseases 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 108700003824 lysine(6)-glutaryl-2-anthraquinone LHRH Proteins 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000002969 morbid Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 238000003911 water pollution Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
- A23K10/18—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/225—Lactobacillus
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Polymers & Plastics (AREA)
- Virology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Animal Husbandry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Food Science & Technology (AREA)
- Birds (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Physiology (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Marine Sciences & Fisheries (AREA)
- Insects & Arthropods (AREA)
- General Engineering & Computer Science (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Description
Claims (5)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910765613.7A CN110408573B (zh) | 2019-08-19 | 2019-08-19 | 一种鼠李糖乳杆菌yfi-6及其在抗大鲵虹彩病毒中的应用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910765613.7A CN110408573B (zh) | 2019-08-19 | 2019-08-19 | 一种鼠李糖乳杆菌yfi-6及其在抗大鲵虹彩病毒中的应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN110408573A true CN110408573A (zh) | 2019-11-05 |
CN110408573B CN110408573B (zh) | 2020-06-19 |
Family
ID=68368026
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201910765613.7A Expired - Fee Related CN110408573B (zh) | 2019-08-19 | 2019-08-19 | 一种鼠李糖乳杆菌yfi-6及其在抗大鲵虹彩病毒中的应用 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN110408573B (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111440739A (zh) * | 2020-04-01 | 2020-07-24 | 中国水产科学研究院长江水产研究所 | 一种地衣芽孢杆菌yfi-2及其在制备淡水养殖动物病毒病药物中的应用 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104411182A (zh) * | 2012-04-12 | 2015-03-11 | 杜邦营养生物科学有限公司 | 微生物菌株及其在动物中的用途 |
-
2019
- 2019-08-19 CN CN201910765613.7A patent/CN110408573B/zh not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104411182A (zh) * | 2012-04-12 | 2015-03-11 | 杜邦营养生物科学有限公司 | 微生物菌株及其在动物中的用途 |
Non-Patent Citations (2)
Title |
---|
HOSEINIFAR SH ET AL.: "Probiotics as Means of Diseases Control in Aquaculture, a Review of Current Knowledge and Future Perspectives", 《FRONT. MICROBIOL》 * |
S.K. NAYAK: "Probiotics and immunity: A fish perspective", 《FISH & SHELLFISH IMMUNOLOGY》 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111440739A (zh) * | 2020-04-01 | 2020-07-24 | 中国水产科学研究院长江水产研究所 | 一种地衣芽孢杆菌yfi-2及其在制备淡水养殖动物病毒病药物中的应用 |
CN111440739B (zh) * | 2020-04-01 | 2021-04-16 | 中国水产科学研究院长江水产研究所 | 一种地衣芽孢杆菌yfi-2及其在制备淡水养殖动物病毒病药物中的应用 |
Also Published As
Publication number | Publication date |
---|---|
CN110408573B (zh) | 2020-06-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN108865953A (zh) | 一株广谱抑制水产病原性弧菌的芽孢杆菌及其复合菌制剂 | |
CN102154176B (zh) | 一种大菱鲆致病菌株及腹水病灭活疫苗 | |
CN101781627A (zh) | 海水蛭弧菌微生态制剂的制备与应用 | |
CN114085789B (zh) | 戊糖片球菌ma.wtpqj01及其应用 | |
CN107338198A (zh) | 一种植物乳杆菌及其应用 | |
CN106148231B (zh) | 一株粪肠球菌y17及其筛选培养与应用 | |
CN109735471A (zh) | 一株微小杆菌及其作为益生菌在水产上的应用 | |
CN110468069A (zh) | 一种干酪乳杆菌yfi-5及其在抗鲤疱疹病毒ii型中的应用 | |
CN102559534B (zh) | 一种蜡样芽孢杆菌及其制剂和应用 | |
CN114437964B (zh) | 一株贝莱斯株芽孢杆菌及其应用 | |
CN113293143B (zh) | 一株可降低鸡白痢沙门氏菌垂直传播的沙门氏菌噬菌体及其应用 | |
CN105132310B (zh) | 一株冷水鱼益生菌芽孢杆菌菌株及其用途 | |
CN110423714A (zh) | 一种乳酸菌复合菌剂及其在抗鲤疱疹病毒ii型中的应用 | |
CN112538442B (zh) | 一株地衣芽孢杆菌及其应用 | |
CN106591206B (zh) | 一株蜡样芽孢杆菌及其复合菌制剂和制备方法 | |
CN110408573A (zh) | 一种鼠李糖乳杆菌yfi-6及其在抗大鲵虹彩病毒中的应用 | |
CN117070472A (zh) | 一株针对高致病性弧菌及耐药弧菌的副溶血弧菌噬菌体及应用 | |
CN117070471A (zh) | 一株可口服进入血液的多价沙门氏菌噬菌体及其应用 | |
CN109706125B (zh) | 蜡样芽孢杆菌噬菌体组合物及其应用 | |
CN109880767A (zh) | 一株用于预防或治疗对虾弧菌病的菌株 | |
CN116042541A (zh) | 一种溶藻弧菌噬菌体grnrz-p25及其应用 | |
CN112592851B (zh) | 一株对水产病原菌有广谱拮抗作用的嗜酸乳杆菌及其应用 | |
CN115927206A (zh) | 一株跨种属裂解型克罗诺杆菌噬菌体及其用途 | |
CN114317339A (zh) | 一种鸽源约氏乳杆菌及其应用 | |
CN110408574A (zh) | 一种乳酸菌复合菌剂及其在抗大鲵虹彩病毒中的应用 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right |
Effective date of registration: 20220810 Address after: No. 2, 3rd Floor, Building 1, Wuda Huiyuan, Phase 5, National Geospatial Information Industry Base, No. 7, Wudayuan 1st Road, Donghu New Technology Development Zone, Wuhan City, Hubei Province 430223 Patentee after: Wuhan Donglikang Life Science Co., Ltd. Address before: 430223 No.8, wudayuan 1st Road, Donghu New Technology Development Zone, Wuhan City, Hubei Province Patentee before: YANGTZE RIVER FISHERIES Research Institute CHINESE ACADEMY OF FISHERY SCIENCES |
|
TR01 | Transfer of patent right | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20200619 |
|
CF01 | Termination of patent right due to non-payment of annual fee |