CN110251418A - A kind of replenishing water and preserving moisture cosmetic composition and preparation method thereof - Google Patents
A kind of replenishing water and preserving moisture cosmetic composition and preparation method thereof Download PDFInfo
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- CN110251418A CN110251418A CN201910493841.3A CN201910493841A CN110251418A CN 110251418 A CN110251418 A CN 110251418A CN 201910493841 A CN201910493841 A CN 201910493841A CN 110251418 A CN110251418 A CN 110251418A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Abstract
The invention discloses a kind of replenishing water and preserving moisture cosmetic compositions and preparation method thereof, it is matched and is prepared by following raw material: 3-30 parts of glycine betaine, 0.5-5 parts of trehalose, 0.05-0.5 parts of hyaluronic acid, 1-10 parts of glyceryl ester, saualane 1-10 parts of synthesis, 0.2-2 parts of phytosterol dimerization Asia oleyl alcohol dimerized linoleic acid ester.Mentioned component is added cosmetics customary adjuvant and lotion, cream, Essence dosage form skin care item is made.The present invention is the replenishing water and preserving moisture cosmetics for promoting moisture content of skin, synergistic by moisturizing ingredient reasonable compatibility prescription needed for a variety of skins, can be obviously improved moisture content of skin.
Description
Technical field
The present invention relates to a kind of cosmetics and its preparation, in particular to a kind of moisturizing according to skin moisture-keeping mechanismic design
Moisturizing cosmetic and preparation method thereof.
Background technique
Replenishing water and preserving moisture cosmetics, a kind of cosmetics that environment (dust storm, cold, drying) invades skin can be resisted by referring to.
The skin of health should be moisten, be soft, high resilience and gloss, in the cuticula of normal health skin, need to keep enough and contain
Water, to safeguard the wet and elasticity of skin, the main source of cuticula moisture is the sweat of sweat gland secretion.Skin physiology
The research of skin moisture-keeping is thought, forms one layer of emulsification skin in skin surface after the sebum and sweat and water emulsification of skin surface
Membrane of lipoprotein, this layer of sebum film can prevent moisture from evaporating, to keep the moisture contained in keratoderma, another keratoderma
It is middle to there is a kind of water-soluble substance for being known as natural moisturizing factor NMF, important work is played to the moisture in holding cuticula
With, and sebum film can prevent the loss of natural moisturizing factor, and play control action appropriate to the volatilization of moisture, and make angle
Matter layer keeps certain moisture.When the influence due to age and external environment such as cold and drying, so that skin moisture-keeping mechanism
It being damaged, when so that the content of the moisture in cuticula dropping to 10% or less, skin will seem drying, follow the string,
Corrugation accelerates skin aging.Therefore, it is kept the skin wet by replenishing water and preserving moisture skin care item to skin, natural moisturizing factor and class skin
Rouge, to keep the normal operation of the content of moisture and skin moisture-keeping mechanism in skin, to restore and keep the wetting of skin
Property, so that skin is seemed healthy, delay skin aging.So alternatively replenishing water and preserving moisture cosmetics are that one kind can be with pole to skin
Significantly ratio keep the skin wet, the skin protection cosmetics of natural moisturizing factor NMF, skin lipid, be the Maintenance Of Skin Health most base
The product of plinth only further could implement the maintenance workers such as anti-aging, whitening to skin under the premise of carrying out replenishing water and preserving moisture
Make.
The natural moisturizing factor NMF of human skin is mainly by amino acids moisturizer, hyaluronic acid, 2-pyrrolidone-5-carboxylic acid
The composition such as sodium.Skin sebum is mainly made of triglyceride, squalene, ceramide, oleic acid etc..Good Emollient materials should be
Substance similar with the component of sebum and natural moisturizing factor in skin, therefore Emollient materials can be divided into oil-soluble and water-soluble
Two classes of property, are referred to as moisturizing agent and moisturizer.
One, moisturizer
1 amino acids moisturizer:
(1) glycine betaine: being present in skin and hair, is one of NMF main component.Beet root is extracted from, in salty sum
In dry environment, all containing the glycine betaine of high level in living cells.Can moisturizing, as osmotic pressure adjust protective agent;Stimulation
Fibroblast vigor promotes the synthesis of collagen, improves skin elasticity.Skin is protected, the mechanical thorn in environment is reduced
Sharp, chemical stimulation and surfactant stimulate the reaction are applicable in and sensitive skin and infant formula.
(2) trehalose:
Desert ' resurrection plant ' scaly leaf Selaginella tamariscina quickly rejuvenates because that can meet water containing trehalose.Scaly leaf Selaginella tamariscina and
Rtardigrade survives under very dry environment, and they can recovery when having water.Trehalose causes this phenomenon
Main cause, because those organisms trehalose synthesis and can gather in vivo it.Trehalose facilitates the preservation of organism,
So it is referred to as " sugar of life " and in the extensive concern for just causing people in the middle of the 19th century.It derives from bioengineering.
There is moisturizing, cytoprotection, inhibit human body bad smell.
2 hyaluronic acids: hyaluronic acid (hyaluronate acid, HA) is closed by the isocellular endochylema film of fibroblast
At almost with the presence of hyaluronic acid in whole body all tissue and body fluid, more than half hyaluronic acid of human body is present in skin
In skin, hyaluronic acid is present in intercellular extracellular matrix in skin, is intercellular filler, in epidermis and corium
Contain hyaluronic acid.Water retention of the HA in skin histology is one of its most important physiological function, and theoretical water retention value is high
Up to 1000ml/g or more, the strand of length mutually twist be made into it is netted, in addition with the Hydrogenbond of water, to play very strong
Water retention.With advancing age, the content of HA reduces in skin, skin tissue cell and intercellular moisture content with
Reduction, therefore it is very necessary that hyaluronic acid is replenished in time.
Two, class sebum moisturizing agents
1. glyceryl ester: class sebum main component.
2. synthesizing saualane: class sebum main component.
3. phytosterol dimerization Asia oleyl alcohol dimerized linoleic acid ester: class sebum main component helps to repair skin esterification film
Barrier.
In conclusion this product foundation skin itself moisturizing mechanism, by supplementing the naturally occurring water solubility of skin comprehensively
The main component of natural moisturizing factor NMF and sebum have the function of that safety is homologous, can be obviously improved moisture content of skin.Comparison
The existing replenishing water and preserving moisture product in market, supplement can provide moisturizing ingredient more comprehensively and be easy directly utilized by skin.
Summary of the invention
In order to solve the problems in the existing technology, the present invention provide a kind of replenishing water and preserving moisture cosmetic composition and its
Preparation method, solve in the prior art replenishing water and preserving moisture cosmetics supplement moisturizing ingredient it is not comprehensive enough, with skin itself natural moisture preserving
The problem that factor NMF and sebum similarity are not high enough etc..
The technical scheme is that
A kind of replenishing water and preserving moisture cosmetic composition is matched by following raw material and is prepared: 3-30 parts of glycine betaine, seaweed
It is 0.5-5 parts sugared, 0.05-0.5 parts of hyaluronic acid, 1-10 parts of glyceryl ester, saualane 1-10 parts is synthesized, phytosterol dimerization is sub-
0.2-2 parts of oleyl alcohol dimerized linoleic acid ester.
It is prepared preferably, replenishing water and preserving moisture cosmetic composition of the present invention is extracted by following raw material: glycine betaine
10-20 parts, 0.75-2.5 parts of trehalose, 0.075-0.25 parts of hyaluronic acid, 2-6 parts of glyceryl ester, saualane 2-6 parts is synthesized,
0.3-1 parts of phytosterol dimerization Asia oleyl alcohol dimerized linoleic acid ester.
Raw material is added cosmetics and lotion dosage form often is made with auxiliary material.The auxiliary material includes moisturizer, emollient, solvent, increasing
Thick dose, emulsifier, film forming agent, preservative, aromatic, chelating agent, PH regulator.The lotion dosage form include lotion, cream,
Essence.
The preparation method of replenishing water and preserving moisture cosmetic composition, comprising the following steps:
(1) solvent for use (water) be heated in advance 80-85 DEG C kept for 30 minutes after to be down to room temperature spare, be weighed by formula
Glycine betaine, trehalose, hyaluronic acid and other water-soluble materials: water phase tank is added in moisturizer, thickener, chelating agent;
(2) be weighed by formula glyceryl ester, synthesis saualane, phytosterol dimerization Asia oleyl alcohol dimerized linoleic acid ester and its
His Oil soluble materials: oily phase tank is added in emollient, emulsifier;
(3) it is mixed water phase and oily phase raw material to form lotion, temperature remains unchanged, and opens vacuum defoamation;It opens equal
Matter emulsification, 5-8 minutes, starts to cool down;
(4) it is cooled to 45-55 DEG C, sequentially adds PH regulator, film forming agent, stirring is uniformly mixed each component;
(5) it is cooled to 40-45 DEG C, sequentially adds preservative, aromatic, stirring is uniformly mixed each component;
(6) 35 DEG C are cooled to, sampling carries out the inspection of semifinished product, after the assay was approved to physical and chemical index, filtering and discharging;
(7) after the inspection of semifinished product is qualified, filling, packaging is carried out, sampling carries out product inspection, after passing the inspection, at
Product outbound is let pass.
The invention has the benefit that replenishing water and preserving moisture skin care item of the present invention pass through supplement according to skin itself moisturizing mechanism
The main component of water-soluble natural moisturizing factor NMF and sebum have the function of being obviously improved moisture content of skin.
Detailed description of the invention
Fig. 1 tries out product of the present invention 0 hour, 2 hours, 4 hours, 6 hours moisture content of skin test results.
Fig. 2 tries out product of the present invention and to the competing product moisture content of skin test result of mark.
Specific embodiment
The present invention is described in further detail with reference to the accompanying drawings and examples.
Embodiment 1
Raw material is weighed according to formula as below: 30 parts of glycine betaine, 5 parts of trehalose, 0.05 part of hyaluronic acid, glyceryl ester 10
Part, 10 parts of saualane are synthesized, 0.2 part of phytosterol dimerization Asia oleyl alcohol dimerized linoleic acid ester.Water used is heated to 80-85 in advance
It is spare that room temperature is down to after DEG C being kept for 30 minutes, and formula weighs glycine betaine, trehalose, hyaluronic acid and other water-soluble materials and adds
Enter water phase tank.Formula weighs glyceryl ester, synthesis saualane, phytosterol dimerization Asia oleyl alcohol dimerized linoleic acid ester and other oil
Oily phase tank is added in dissolubility raw material.It is mixed water phase and oily phase raw material to form lotion, temperature remains unchanged, and it is de- to open vacuum
Bubble.Emulsifying is opened, 5-8 minutes, starts to cool down.It is cooled to 45-55 DEG C, sequentially adds thickener, film forming agent, stirring makes
Each component is uniformly mixed.It is cooled to 40-45 DEG C, sequentially adds preservative, aromatic, stirring is uniformly mixed each component.It is cold
But to 35 DEG C, lotion is formed, sampling carries out the inspection of semifinished product, after the assay was approved to physical and chemical index, filtering and discharging.To semi-finished product
After the assay was approved, filling, packaging is carried out, sampling carries out product inspection, and after passing the inspection, finished product outbound is let pass.
It can be docosyl alcohol (0.2-2.0 parts), solvent can be water that auxiliary material moisturizer, which can be glycerol (0.5-5.0 parts), emollient,
(40-80 parts), thickener can be xanthan gum (0.02-0.2 parts), emulsifier can be stearine (0.2-1.6 parts), at
It can be Phenoxyethanol (0.1-1.0 parts), aromatic can be (day that film, which can be polyquaternium -51 (0.3-3.0 parts), preservative,
With) essence (0.01-0.1 parts), chelating agent can be EDETATE SODIUM (0.01-0.1 parts), PH regulator can be potassium hydroxide
(0.01-0.1 parts).
Efficacy test experiment:
1, it experimental program: is carried out according to " GMYF-JC-001-2018 moisturizer efficacy test standard detection regulation ".
Selected target user.Laboratory apparatus: 580 (water containing skin of skin elasticity tester Cutometer dual MPA
Divide test probe).By taking Qi deficiency physique conditioning samples some cycles, main body matter before and after constitution conditioning products is taken in comparison
The variation of scoring, is analyzed by paired-samples T-test, determines whether result has significant difference.
2, experimenter: selected 7 people of target user.
3, experimental period: 0-6 hours.
4, laboratory sample: test sample and commercially available competing product.
5, experimental result:
As shown in Figure 1, comparison 7 person on probations, 0 hour, 2 hours, 4 hours and 6 hours moisture content of skin: on probation 0
Hour, the average test numerical value 30.6 of person on probation;2 hours, the average test numerical value 44.4 of person on probation;It 4 hours, tries out
The average test numerical value 46.5 of personnel;6 hours, the average test numerical value 47.1 of person on probation.It is analyzed by SPSS software, it is double
The P value < 0.05 of side paired t-test, difference is statistically significant.Show tester 0 hour and 6 hours moisture content of skin have
Significant difference.
As shown in Fig. 2, comparison 7 person on probations, 0 hour, 2 hours, 4 hours and 6 hours moisture content of skin: on probation 0
Hour, the average test numerical value 29.5 of person on probation;The average test numerical value 29.2 of commercial product.2 hours, person on probation's
Average test numerical value 46.0;The average test numerical value 41.2 of commercial product.4 hours, the average test numerical value of person on probation
46.9;The average test numerical value 40.3 of commercial product.6 hours, the average test numerical value 49.9 of person on probation;Commercial product
Average test numerical value 43.9.It is analyzed by SPSS software, the P value < 0.05 of bilateral paired t-test, difference is statistically significant.
Show that test sample increases moisture content of skin effect in 2h, 4h, 6h and is better than commercial product, and have extremely significant sex differernce (p≤
0.01).6, experiment conclusion:
Test sample has in 2h, 4h, 6h increases moisture content of skin effect, and is extremely significant sex differernce (p≤0.01);
Test sample increases moisture content of skin effect in 2h, 4h, 6h and is better than commercial product, and have extremely significant sex differernce (p≤
0.01).The result shows that: the product has good result to moisture content of skin moisturizing is improved.
It is all to be made using description of the invention and accompanying drawing content the foregoing is merely the preferred embodiment of the present invention
Several improvement or deformation, being applied directly or indirectly in other relevant technical fields, also should be regarded as in patent of the invention
In protection scope.
Claims (6)
1. a kind of replenishing water and preserving moisture cosmetic composition, which is characterized in that matched and prepared by following raw material: glycine betaine 3-30
Part, 0.5-5 parts of trehalose, 0.05-0.5 parts of hyaluronic acid, 1-10 parts of glyceryl ester, saualane 1-10 parts is synthesized, phytosterol
0.2-2 parts of dimerization Asia oleyl alcohol dimerized linoleic acid ester.
2. replenishing water and preserving moisture cosmetic composition according to claim 1, which is characterized in that extracted and made by following raw material
It is standby: 10-20 parts of glycine betaine, 0.75-2.5 parts of trehalose, 0.075-0.25 parts of hyaluronic acid, 2-6 parts of glyceryl ester, to synthesize spiny dogfish
2-6 parts of alkane, 0.3-1 parts of phytosterol dimerization Asia oleyl alcohol dimerized linoleic acid ester.
3. replenishing water and preserving moisture cosmetic composition according to claim 1, which is characterized in that raw material is added cosmetics and often uses auxiliary material
Lotion dosage form is made.
4. replenishing water and preserving moisture cosmetic composition according to claim 4, which is characterized in that the auxiliary material includes moisturizer, profit
Skin agent, solvent, thickener, emulsifier, film forming agent, preservative, aromatic, chelating agent, PH regulator.
5. replenishing water and preserving moisture cosmetic composition according to claim 4, which is characterized in that the lotion dosage form include lotion,
Cream, Essence.
6. the preparation method of replenishing water and preserving moisture cosmetic composition described in -6 any one claims according to claim 1, special
Sign is, comprising the following steps:
(1) water used in be heated in advance 80-85 DEG C kept for 30 minutes after to be down to room temperature spare, be weighed by formula glycine betaine, seaweed
Sugar, hyaluronic acid and other water-soluble materials: water phase tank is added in moisturizer, thickener, chelating agent;
(2) it is molten that glyceryl ester, synthesis saualane, phytosterol dimerization Asia oleyl alcohol dimerized linoleic acid ester and other oil are weighed by formula
Property raw material: oily phase tank is added in emollient, emulsifier;
(3) it is mixed water phase and oily phase raw material to form lotion, temperature remains unchanged, and opens vacuum defoamation;Open homogenized milk
Change, 5-8 minutes, starts to cool down;
(4) it is cooled to 45-55 DEG C, sequentially adds PH regulator, film forming agent, stirring is uniformly mixed each component;
(5) it is cooled to 40-45 DEG C, sequentially adds preservative, aromatic, stirring is uniformly mixed each component;
(6) 35 DEG C are cooled to, sampling carries out the inspection of semifinished product, after the assay was approved to physical and chemical index, filtering and discharging;
(7) after the inspection of semifinished product is qualified, filling, packaging is carried out, sampling carries out product inspection, and after passing the inspection, finished product goes out
It lets pass in library.
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CN201910493841.3A CN110251418A (en) | 2019-06-07 | 2019-06-07 | A kind of replenishing water and preserving moisture cosmetic composition and preparation method thereof |
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Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20100035005A (en) * | 2008-09-25 | 2010-04-02 | 유한킴벌리 주식회사 | Cosmetic composition for kids with high moisturizing effects |
CN106511160A (en) * | 2016-11-08 | 2017-03-22 | 宁夏艾伊生物工程研发有限公司 | Moisturizing cream and preparation method thereof |
-
2019
- 2019-06-07 CN CN201910493841.3A patent/CN110251418A/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20100035005A (en) * | 2008-09-25 | 2010-04-02 | 유한킴벌리 주식회사 | Cosmetic composition for kids with high moisturizing effects |
CN106511160A (en) * | 2016-11-08 | 2017-03-22 | 宁夏艾伊生物工程研发有限公司 | Moisturizing cream and preparation method thereof |
Non-Patent Citations (2)
Title |
---|
国家药品监督管理局: "《如颂莹润沁透保湿乳液》", 5 March 2019 * |
裘炳毅等: "《现代化妆品科学与技术》", 31 March 2016, 中国轻工业出版社 * |
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