CN106389234B - Anti-ageing composition and cosmetics - Google Patents
Anti-ageing composition and cosmetics Download PDFInfo
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- CN106389234B CN106389234B CN201611073792.0A CN201611073792A CN106389234B CN 106389234 B CN106389234 B CN 106389234B CN 201611073792 A CN201611073792 A CN 201611073792A CN 106389234 B CN106389234 B CN 106389234B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
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- A61K8/06—Emulsions
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/26—Optical properties
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
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Abstract
The present invention relates to cosmetic technical field, in particular to anti-ageing composition and cosmetics.The anti-ageing composition is made of imperial rice bran oil nano-emulsion, Olive leaf P.E, jujube extract and rutin.The present invention prepares imperial rice bran oil nano-emulsion by nano-emulsion formation basic theory, has good protective effect to oxidizable imperial rice bran oil, improves its bioavilability, while improving the compatibility of imperial rice bran oil and water-soluble substances.The addition of imperial rice bran oil nano-emulsion, promotes the absorption of Olive leaf P.E, jujube extract, rutin, and 4 kinds of components have significant synergistic function in terms of anti-ageing effect.It is main composition that the present invention, which drives 4 kinds of rice bran oil nano-emulsion, Olive leaf P.E, jujube extract and rutin raw materials, natural safety, can effectively be moisturized the skin, anti-ageing anti-wrinkle, enhancing skin elasticity.
Description
Technical field
The present invention relates to cosmetic technical field, in particular to anti-ageing composition and cosmetics.
Background technique
Skin aging is the skin aging phenomenon as caused by natural cause or non-natural factor.Skin histology day after people's birth
It reaches increasingly, function is gradually active, will start to degenerate when reaching certain age, and this degeneration is often unconsciously slow in people
Slow-motion row.The growth stage of skin histology generally ends at 25 years old or so, and the growth with aging of skin carry out simultaneously after this, skin
Skin elastic fibers is gradually thicker, and after 35 years old, the aging rate of skin is accelerated, increasingly apparent.
With the improvement of living standards, people are further strong to the desire for keeping skin youth, but skin aging is one
A natural, inevitable process, therefore become the problem of much liking to be beautiful women worry.Cause skin aging because being known as very
It is more, such as increase, operating pressure, air pollution, ultraviolet injury and the hormonal missing at age, these will lead in vivo
Free radical increases, glycosylation end product level improves and proteasome activity reduces, so that it is dry, old to promote skin to occur
The problem of aging such as spot, wrinkle, relaxation.Cosmetics and skincare product appropriate is selected, the prefered method of skin aging is resisted at people.
The cosmetics and skincare product of different brands can be found everywhere in the market, however, most of skin care item are quick, direct in order to pursue
Effect, using different chemicals as additive, since certain side effects of chemicals cause to skin and body
Some damages of body.Therefore, from nature seek it is some have preferable activity of fighting against senium extract or extract combination, instead of
Traditional chemicals is increasingly becoming the trend and trend in market as the adding ingredient of cosmetics and skincare product.
Currently, most of anti-ageing products in the market, although adding various innate efficacy ingredients, because its absorbability is bad
Cause effect unsatisfactory.Or it is that hospital carries out sodium hyaluronate and botulinum toxin injection, laser nti-freckle, facelift etc., these
Mode is expensive, and risk is big.Therefore the anti-ageing product of a kind of good absorbability, significant effect, natural safety is developed with weight
The meaning wanted.
Summary of the invention
In view of this, the present invention provides anti-ageing composition and cosmetics.The anti-ageing composition is naturally safe, anti-ageing effect
Significantly.
In order to achieve the above-mentioned object of the invention, the present invention the following technical schemes are provided:
The present invention provides a kind of anti-ageing compositions, by imperial rice bran oil nano-emulsion, Olive leaf P.E, jujube extract and rutin
Composition.
Imperial rice bran oil, also known as poppy seed oil are a kind of containing the natural of high compound nutritional ingredient without habituation ingredients such as morphines
Rare green plants oil.According to the survey report for the Institute of Science and Technology, National Food Bureau that related production unit provides, (1) is containing rich
Rich polyunsaturated fatty acid, including palmitinic acid 10.7%, stearic acid 1.6%, oleic acid 21.9%, linoleic acid 66.5%, flax
Acid 0.8%, the propellant of these Fatty acid compositions human metabolism, and there is skin care, Exfoliating Scrub and anti-aging
Effect；(2) day heptose rich in, D-mannoheptulose and other active peptides and polysaccharide and cupreol, racemization flesh
The alcohols such as pure and mild ring laudanum alcohol, increase substantially the immunity of people, anti-aging；(3) antioxidant VE rich in
Cardio-cerebrovascular can be improved from dimension ability, heart tonifying and brain strengthening in (231mg/kg) and microelement, including selenium, magnesium, calcium, phosphorus etc.；
(4) contain micro flavones and phytosterol, can strongly improve kidney power, make one to retain youthful vitality；It (5) cannot be certainly containing human body
Row synthesizes but required eight kinds of amino acid: leucine, isoleucine, valine, phenylalanine, methionine, lysine, Soviet Union's ammonia
Acid and tryptophan.Imperial rice bran oil has reducing blood lipid, inhibition thrombosis, lipid peroxidation inhibition, anti-aging, improves human immunity function
The good action that can, increase cell activity, improve skin elasticity, soft skin.
Nano-emulsion is outside the one kind spontaneously formed under appropriate proportion by water, oil, surfactant and cosurfactant
Thermodynamic stable system as clear as crystal or translucent, that viscosity is low is seen, partial size is between 10~100nm.Nano-emulsion is each at present
The application of kind cosmetics, is mainly used for solubilising, slow-release controlled-release and the protection of effective component, and the biology of effective component can be improved
The stability of availability and preparation promotes the absorption etc. of cosmetics.Compared with Traditional makeup emulsion, producing of nano-emulsion
There are many clear advantages when cosmetic: optical clear, nano-emulsion spontaneously form, and have the characteristics that energy-efficient, stability
It is relatively good, there can be good solubilization with long-term storage, the higher product of oil composition can be made, and product is without greasy
Sense has good comfort when use, and Cutaneous permeation effect is fast, and Transdermal absorption effect is good.
Olive leaf P.E is rich in oleuropein, is to maintain multi-functional dose of skin health and vigor, reactivates albumen
Enzyme body promotes cell toxin expelling, the ager process of delaying skin cell.
Jujube extract derives from jujube, and contained VC is 100 times of typical apple, and principle active component is semen ziziphi spinosae soap
Glycosides can promote wound healing, reinforce the anti-oxidant repair system of skin, strengthen and repair skin.
Rutin, also known as rutin, citrin, rutin, having reduces capillary permeability and brittle effect,
The normal elasticity of capillary is kept and restored, in addition, rutin has extremely strong absorption to ultraviolet light, can be used as natural anti-
Agent is shone, while there is significant scavenging effect to active oxygen radical and hydroxyl radical free radical, can effectively prevent the light aging of skin.
The present invention has significant after imperial rice bran oil nano-emulsion, Olive leaf P.E, jujube extract and rutin are applied in combination
Anti-ageing effect, effect are better than each component exclusive use, embody apparent synergistic function.The composition is applied and is being made up
In product, the trend of cosmetic industry has been complied with, has met consumer's demand natural to cosmetics, green, safe and efficient.
Preferably, in parts by weight, which includes: 10~20 parts of imperial rice bran oil nano-emulsion, olive leaf is extracted
0.5~3 part of object, 1~5 part of jujube extract, 0.8~2.5 part of rutin.
In an embodiment provided by the invention, in parts by weight, which includes: imperial rice bran oil nano-emulsion 20
Part, 0.5 part of Olive leaf P.E, 3 parts of jujube extract, 1 part of rutin.
In another embodiment provided by the invention, in parts by weight, which includes: imperial rice bran oil nano-emulsion 10
Part, 1.6 parts of Olive leaf P.E, 5 parts of jujube extract, 0.8 part of rutin.
In another embodiment provided by the invention, in parts by weight, which includes: imperial rice bran oil nano-emulsion 15
Part, 3 parts of Olive leaf P.E, 1 part of jujube extract, 2.5 parts of rutin.
Preferably, imperial rice bran oil nano-emulsion is grouped as by following group in terms of mass percentage:
Preparation method are as follows: surfactant and oil are mixed, the cosurfactant containing imperial rice bran oil is then added,
It is stirring evenly and then adding into water, stirs to get imperial rice bran oil nano-emulsion.
Preferably, surfactant is one or both of Tween-80, Crodaret.
Preferably, cosurfactant is one or both of propylene glycol, 1,3-BDO.
Preferably, oil is mutually one or more of isopropyl myristate, jojoba oil, wheat-germ oil.
In embodiment provided by the invention, Crodaret is Crodaret 40.
The present invention also provides a kind of cosmetics, including imperial rice bran oil nano-emulsion, Olive leaf P.E, jujube extract, rutin
With auxiliary material acceptable on cosmeceutical.
In embodiment provided by the invention, the dosage form of cosmetics is gel, acceptable auxiliary on cosmeceutical in gel
Material includes moisturizer, glycerol, thickener, Sensiva SC50,1,2- hexylene glycol, rose, triethanolamine and water.
Preferably, in terms of mass percentage, dosage of each component in gel are as follows:
Preferably, moisturizer is ethoxy urea, ceramide, Sodium Hyaluronate, beta glucan, reed fragrant plant oil, sorbose
One or more of alcohol, glycine betaine or amino acid humectant.
Preferably, thickener is one of carbomer, xanthan gum, seaweed glue, Arabic gum or tara gum or several
Kind.
Preferably, the pH value of gel is 5~6.5.
Preferably, the preparation method of the gel includes the following steps:
Glycerol, thickener are mixed with 80~90 DEG C of water, 3~5min of homogeneous is swollen it sufficiently；
When temperature is down to 40~45 DEG C, imperial rice bran oil nano-emulsion, Olive leaf P.E, jujube extract, rutin, moisturizing is added
Agent stirs evenly；
When temperature is down to 15~30 DEG C, be added triethanolamine adjust pH be 5~6.5, then be added Sensiva SC50,
1,2- hexylene glycol, rose, stir evenly, and obtain gel.
The present invention provides anti-ageing composition and cosmetics.The anti-ageing composition is extracted by imperial rice bran oil nano-emulsion, olive leaf
Object, jujube extract and rutin composition.The present invention at least has one of following advantage:
1) present invention prepares imperial rice bran oil nano-emulsion by nano-emulsion formation basic theory, has well to oxidizable imperial rice bran oil
Protective effect improves its bioavilability, while improving the compatibility of imperial rice bran oil and water-soluble substances.
2) addition for driving rice bran oil nano-emulsion, promotes the absorption of Olive leaf P.E, jujube extract, rutin, in anti-ageing function
4 kinds of efficacious prescriptions face component has significant synergistic function.
3) 4 kinds of imperial rice bran oil nano-emulsion of the present invention, Olive leaf P.E, jujube extract and rutin raw materials be primary efficacy at
Point, natural safety can be moisturized the skin effectively, anti-ageing anti-wrinkle, enhancing skin elasticity.
Even if 4) oil component of gel of the invention containing high level, still there is transparent appearance, good stability
With use comfort, quality is salubrious, has no the greasy feeling of ordinary emulsion cream.
Specific embodiment
The invention discloses anti-ageing composition and cosmetics, those skilled in the art can use for reference present disclosure, suitably change
Into realization of process parameters.In particular, it should be pointed out that all similar substitutions and modifications are aobvious for a person skilled in the art
And be clear to, they are considered as being included in the present invention.Method and application of the invention is carried out by preferred embodiment
Description, related personnel can obviously not depart from the content of present invention, carried out in spirit and scope to method described herein and application
Change or appropriate changes and combinations, carry out implementation and application the technology of the present invention.
Raw materials used or auxiliary material is available on the market in anti-ageing composition and cosmetics provided by the invention.
Below with reference to embodiment, the present invention is further explained:
The preparation of the anti-ageing composition of embodiment 1
The formula of imperial rice bran oil nano-emulsion is following (by weight):
Imperial rice bran oil nano-emulsion the preparation method comprises the following steps: surfactant and oil are mixed, stir evenly, be then added and contain
The cosurfactant of imperial rice bran oil, stirs evenly, is finally slowly added to pure water, and is stirred continuously until system clear.
The formula of anti-ageing composition is as follows:
Anti-ageing composition the preparation method comprises the following steps: by imperial rice bran oil nano-emulsion of formula ratio, Olive leaf P.E, jujube extract,
Rutin mixing, obtains anti-ageing composition.
The preparation of the anti-ageing composition of embodiment 2
The formula of imperial rice bran oil nano-emulsion is following (by weight):
Imperial rice bran oil nano-emulsion the preparation method comprises the following steps: surfactant and oil are mixed, stir evenly, be then added and contain
The cosurfactant of imperial rice bran oil, stirs evenly, is finally slowly added to pure water, and is stirred continuously until system clear.
The formula of anti-ageing composition is as follows:
Anti-ageing composition the preparation method comprises the following steps: by imperial rice bran oil nano-emulsion of formula ratio, Olive leaf P.E, jujube extract,
Rutin mixing, obtains anti-ageing composition.
The preparation of the anti-ageing composition of embodiment 3
The formula of imperial rice bran oil nano-emulsion is following (by weight):
Imperial rice bran oil nano-emulsion the preparation method comprises the following steps: surfactant and oil are mixed, stir evenly, be then added and contain
The cosurfactant of imperial rice bran oil, stirs evenly, is finally slowly added to pure water, and is stirred continuously until system clear.
The formula of anti-ageing composition is as follows:
Anti-ageing composition the preparation method comprises the following steps: by imperial rice bran oil nano-emulsion of formula ratio, Olive leaf P.E, jujube extract,
Rutin mixing, obtains anti-ageing composition.
The antioxidation in vitro of the anti-ageing composition of test example 1 is tested
Experiment purpose: in vitro test, the antioxidant effect of plant extract composition is investigated.
Experimental material: free radical scavenging activity (referred to as: DPPH, Sigma company, the U.S.)；Du800 UV, visible light
Spectrophotometer (Beckman company, the U.S.)；The composition prepared in embodiment 1-3, imperial rice bran oil nano-emulsion in embodiment 3,
Olive leaf P.E, jujube extract, rutin, the concentration of preparation are 6%.
Experimental method: taking 0.1mL sample solution, and the DPPH solution that 60 μm of ol/L of 2mL are added mixes, and places 30min, with
Former solvent zeroising, it is Ai that absorbance has been surveyed at 515nm；Measurement absorbance is mixed with method 0.1mL solvent+2mL DPPH solution
Extremely Ac；0.1mL sample solution+2mL solvent mixes measurement absorbance extremely Aj.Its radicals scavenging according to the following formula
Rate.
Clearance rate (%)=[1- (Ai-Aj)/Ac] × 100%
Wherein, contribution of the Aj response sample itself to absorbance；Ai sample is to the absorption values after DPPH effect；Ac is
Absorption of the DPPH in measurement wavelength itself.
Experimental result is as follows:
The experiment of 1 plant extract composition oxidation resistance of table
| Sample | Clearance rate (%) |
| Example 1 group closes object | 90.2 |
| 2 composition of embodiment | 93.7 |
| 3 composition of embodiment | 92.4 |
| Imperial rice bran oil nano-emulsion in embodiment 3 | 41.8 |
| Olive leaf P.E | 69.5 |
| Jujube extract | 85.7 |
| Rutin | 81.3 |
Vitro Experimental Results show that 1-3 composition of the embodiment of the present invention has preferable free radical scavenging ability, clearance rate
Higher than each single dose group.
The preparation of the anti-ageing gel of embodiment 4
The formula of anti-ageing gel is following (in terms of mass percentage):
Anti-ageing gel the preparation method is as follows: glycerol, thickener are added in 80 DEG C of hot water, homogeneous 5min makes it
Sufficiently swelling；40 DEG C are down to temperature, sequentially adds imperial rice bran oil nano-emulsion, Olive leaf P.E, jujube extract, rutin, moisturizing
Agent stirs evenly；When temperature drops to room temperature, it is 6.5 that triethanolamine, which is added, and adjusts pH, and Sensiva SC50,1,2- is then added
Hexylene glycol, rose, stir evenly.
The preparation of the anti-ageing gel of embodiment 5
The formula of anti-ageing gel is following (in terms of mass percentage):
Anti-ageing gel the preparation method is as follows: glycerol, thickener are added in 90 DEG C of hot water, homogeneous 4min makes it
Sufficiently swelling；42 DEG C are down to temperature, sequentially adds imperial rice bran oil nano-emulsion, Olive leaf P.E, jujube extract, rutin, moisturizing
Agent stirs evenly；When temperature drops to room temperature, it is 5 that triethanolamine, which is added, and adjusts pH, be then added Sensiva SC50,1,2- oneself
Glycol, rose, stir evenly.
The preparation of the anti-ageing gel of embodiment 6
The formula of anti-ageing gel is following (in terms of mass percentage):
Anti-ageing gel the preparation method is as follows: glycerol, thickener are added in 100 DEG C of hot water, homogeneous 3min makes it
Sufficiently swelling；45 DEG C are down to temperature, sequentially adds imperial rice bran oil nano-emulsion, Olive leaf P.E, jujube extract, rutin, moisturizing
Agent stirs evenly；When temperature drops to room temperature, it is 5.8 that triethanolamine, which is added, and adjusts pH, and Sensiva SC50,1,2- is then added
Hexylene glycol, rose, stir evenly.
The preparation of the anti-ageing gel of embodiment 7
The formula of anti-ageing gel is following (in terms of mass percentage):
Anti-ageing gel the preparation method is as follows: glycerol, thickener are added in 80 DEG C of hot water, homogeneous 5min makes it
Sufficiently swelling；40 DEG C are down to temperature, sequentially adds imperial rice bran oil nano-emulsion, Olive leaf P.E, jujube extract, rutin, moisturizing
Agent stirs evenly；When temperature drops to room temperature, it is 6.2 that triethanolamine, which is added, and adjusts pH, and Sensiva SC50,1,2- is then added
Hexylene glycol, rose, stir evenly.
The preparation of the anti-ageing gel of embodiment 8
The formula of anti-ageing gel is following (in terms of mass percentage):
Anti-ageing gel the preparation method is as follows: glycerol, thickener are added in 90 DEG C of hot water, homogeneous 4min makes it
Sufficiently swelling；45 DEG C are down to temperature, sequentially adds imperial rice bran oil nano-emulsion, Olive leaf P.E, jujube extract, rutin, moisturizing
Agent stirs evenly；When temperature drops to room temperature, it is 6.4 that triethanolamine, which is added, and adjusts pH, and Sensiva SC50,1,2- is then added
Hexylene glycol, rose, stir evenly.
The detection of the anti-ageing gelling performance of test example 2
1, stability test
1) accelerated stability
Take the gel of 4-8 of the embodiment of the present invention in right amount in centrifuge tube, sealing orifice, 3000rpm is centrifuged 30min, does not see
Suspended matter, precipitating and oil slick phenomenon are observed, original appearance is kept.
2) stablize stability
The gel for taking appropriate 4-8 of the embodiment of the present invention is respectively placed in 4,25,37,60 DEG C of environment and investigates 3 months, weekly
Sampling observation, as a result, it has been found that the gel of 4-8 of the embodiment of the present invention keeps the appearance of clear under this four kinds of stable conditions,
Do not occur phenomena such as suspended matter, precipitating and oil slick.
2, security test (human skin patch)
Choosing 20 ages is the health volunteer without skin disease allergies between 25-50 years old, pastes spot method: selecting and closes
The spot tester of lattice takes the gel drops of about 15 μ L embodiment of the present invention 4-8 in spot tester, outside with closed patch experiment method
It is covered on subject back with special adhesive tape, each subject pastes 50 spot testers, respectively the gel of patch examination embodiment 4-8, and 24
Tested material is removed after hour, respectively at observation dermoreaction in 0.5,6,12,24,48 hour after removal, according to " cosmetics health is advised
Model " in dermoreaction grade scale record its result.
Test result: human skin patch test result shows all subjects by patch test, 0.5,6,12,
24, observation dermoreaction in 48 hours illustrates production of the invention wherein 0 the adverse reactions such as erythema, papule, blister occurs
Product are non-stimulated using safe.
3, measure of merit
1) skin is percutaneously lost the test of moisture
Choose health volunteer 30, the age in 25-50, test site room temperature (25 ± 1) DEG C, relative humidity (40 ±
5) %, it is desirable that tester shifts to an earlier date 30min and enters test environment.Tester's inboard arm mark tested person region (4cm ×
4cm), same arm can mark multiple regions (interval 1cm), the equal random distribution of test sample simultaneously.First test each test zone
Blank value, then test specimens press (2.0 ± 0.1) mg/cm2Dosage carry out single smearing, dissipated using moisture of skin after smearing
Commit a breach of etiquette measurement respectively 0,1,2, the tested region 4h and blank control region through transepidermal water windage (TEWL), each region according to
According to being measured in parallel 5 times, any sample is not smeared in blank control region as.The results are shown in Table 2.
The moisture of skin windage (%) of 2 different time (h) of table
As shown in Table 2, skin TEWL can be significantly reduced using anti-ageing gel of the invention, there is moisturizing, slow down
The effect of skin aging.
2) skin elasticity is tested
100 women are chosen, the age between 25-50 years old, is randomly divided into 5 groups, after cleaning is facial, takes suitable present invention
Anti-ageing gel is applied to face, and flicking absorbs, each using once daily morning and evening, using skin elasticity tester, surveys respectively
The skin elasticity index R2 (it is 450mbar that negative pressure is constant in test process) for trying the 1st, 2, the 4 week left cheekbone portion of test, takes user to survey
Test result average value.The skin elasticity index value of 30min is initial value after being cleaned using test zone.Index explanation: skin elasticity
Index R2 illustrates that the elasticity of skin is better closer to 1.Test result is as follows:
The skin elasticity index R2 of 3 different cycles (w) of table
| Test specimens | 0w | 1w | 2w | 4w |
| Embodiment 4 | 0.6301 | 0.6839 | 0.7401 | 0.8417 |
| Embodiment 5 | 0.6275 | 0.6741 | 0.7247 | 0.8154 |
| Embodiment 6 | 0.6582 | 0.7153 | 0.7603 | 0.8522 |
| Embodiment 7 | 0.6629 | 0.7026 | 0.7539 | 0.8372 |
| Embodiment 8 | 0.6580 | 0.6941 | 0.7510 | 0.8471 |
As shown in Table 3, anti-ageing facial mask of the invention can improve skin elasticity, reduce the generation of skin lines and wrinkle, tool
There is Antiageing effect.
3) test of skin mean roughness
100 women are chosen, the age between 25-50 years old, is randomly divided into 5 groups, after cleaning is facial, takes suitable present invention
Anti-ageing gel is applied to face, and flicking absorbs, and each using once daily morning and evening, test carries out 4 times, respectively initial value altogether
After using anti-ageing gel 1 week, 2 weeks, 4 weeks, same time subject cleans position is smeared weekly, uses MicroSkinII
Multi-functional skin mirror image analysis system measures the skin mean roughness of left eye angular region, and the results are shown in Table 4.
The skin mean roughness of 4 different cycles (w) of table
| Test specimens | 0 | 1 | 2 | 4 |
| Embodiment 4 | 24.79 | 22.58 | 20.41 | 18.63 |
| Embodiment 5 | 24.61 | 22.47 | 20.49 | 18.70 |
| Embodiment 6 | 24.75 | 22.53 | 20.56 | 18.82 |
| Embodiment 7 | 24.58 | 22.39 | 20.45 | 18.66 |
| Embodiment 8 | 24.64 | 22.50 | 20.63 | 18.79 |
As shown in Table 4, skin mean roughness can be effectively reduced in anti-ageing gel of the invention, be used for a long time, can reach and dispel
The effect of wrinkle keeps skin more smooth, restores young state.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also answered
It is considered as protection scope of the present invention.
Claims (8)
1. a kind of anti-ageing composition, which is characterized in that in parts by weight, the anti-ageing composition is made of the following raw material: imperial rice
10~20 parts of oil nanometer emulsion, 0.5~3 part of Olive leaf P.E, 1~5 part of jujube extract, 0.8~2.5 part of rutin；
In terms of mass percentage, imperial rice bran oil nano-emulsion is grouped as by following group:
Imperial rice bran oil nano-emulsion the preparation method comprises the following steps: surfactant and oil are mixed, be then added containing imperial rice bran oil
Cosurfactant is stirring evenly and then adding into water, stirs to get imperial rice bran oil nano-emulsion.
2. anti-ageing composition according to claim 1, which is characterized in that the surfactant is Tween-80, polyoxy second
One or both of alkene rilanit special；The cosurfactant is one or both of propylene glycol, 1,3 butylene glycol；
The oil is mutually one or more of isopropyl myristate, jojoba oil, wheat-germ oil.
3. a kind of cosmetics, which is characterized in that including imperial rice bran oil nano-emulsion, Olive leaf P.E, jujube extract, rutin and makeup
Acceptable auxiliary material in conduct and learning；
In parts by weight, ingredient is made of the following raw material the effect of the cosmetics: imperial 10~20 parts of rice bran oil nano-emulsion, olive leaf
0.5~3 part of extract, 1~5 part of jujube extract, 0.8~2.5 part of rutin；
In terms of mass percentage, imperial rice bran oil nano-emulsion is grouped as by following group:
Imperial rice bran oil nano-emulsion the preparation method comprises the following steps: surfactant and oil are mixed, be then added containing imperial rice bran oil
Cosurfactant is stirring evenly and then adding into water, stirs to get imperial rice bran oil nano-emulsion.
4. cosmetics according to claim 3, which is characterized in that the dosage form of the cosmetics is gel, in the gel
Acceptable auxiliary material includes that moisturizer, glycerol, thickener, Sensiva SC50,1,2- hexylene glycol, rose are pure on cosmeceutical
Dew, triethanolamine and water.
5. cosmetics according to claim 4, which is characterized in that in terms of mass percentage, each component in the gel
Dosage are as follows:
6. cosmetics according to claim 4, which is characterized in that the moisturizer is ethoxy urea, ceramide, transparent
One or more of matter acid sodium, beta glucan, reed fragrant plant oil, D-sorbite, glycine betaine or amino acid humectant；The thickener
For one or more of carbomer, xanthan gum, seaweed glue, Arabic gum or tara gum.
7. cosmetics according to claim 4, which is characterized in that the pH value of the gel is 5~6.5.
8. cosmetics according to any one of claims 4 to 7, which is characterized in that the preparation method of the gel includes
Following steps:
Glycerol, thickener are mixed with 80~90 DEG C of water, 3~5min of homogeneous is swollen it sufficiently；
When temperature is down to 40~45 DEG C, imperial rice bran oil nano-emulsion, Olive leaf P.E, jujube extract, rutin, moisturizer is added,
It stirs evenly；
When temperature is down to 15~30 DEG C, it is 5~6.5 that triethanolamine, which is added, and adjusts pH, and Sensiva SC50,1,2- is then added
Hexylene glycol, rose, stir evenly, and obtain gel.
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| CN201611073792.0A CN106389234B (en) | 2016-11-29 | 2016-11-29 | Anti-ageing composition and cosmetics |
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| CN201611073792.0A CN106389234B (en) | 2016-11-29 | 2016-11-29 | Anti-ageing composition and cosmetics |
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| CN106389234B true CN106389234B (en) | 2019-05-17 |
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| CN107496215A (en) * | 2017-10-10 | 2017-12-22 | 西北师范大学 | A kind of natural lip gloss of Fruity type and preparation method |
| CN110680760B (en) * | 2019-10-18 | 2022-04-05 | 广州睿森生物科技有限公司 | Composition containing composite peptide nanoemulsion and application of composition in preparation of cosmetics |
| CN113101256B (en) * | 2021-05-12 | 2022-12-02 | 山东福瑞达生物股份有限公司 | Anti-aging repair nanoemulsion and application thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1226816A (en) * | 1996-08-02 | 1999-08-25 | 普拉姆开米制品股份有限公司 | Oil-in-water emulsion for use on human skin for cleansing, preserving or improving skin condition |
| CN1520802A (en) * | 2003-02-14 | 2004-08-18 | 上海金成食品有限公司 | Cosmetic product containing deactivated poppy seed oil |
| CN101028071A (en) * | 2007-04-16 | 2007-09-05 | 周文志 | Poppy seed oil extract, its production and use |
| CN103462892A (en) * | 2007-11-28 | 2013-12-25 | 联邦科学和工业研究组织 | Nanoemulsions |
-
2016
- 2016-11-29 CN CN201611073792.0A patent/CN106389234B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1226816A (en) * | 1996-08-02 | 1999-08-25 | 普拉姆开米制品股份有限公司 | Oil-in-water emulsion for use on human skin for cleansing, preserving or improving skin condition |
| CN1520802A (en) * | 2003-02-14 | 2004-08-18 | 上海金成食品有限公司 | Cosmetic product containing deactivated poppy seed oil |
| CN101028071A (en) * | 2007-04-16 | 2007-09-05 | 周文志 | Poppy seed oil extract, its production and use |
| CN103462892A (en) * | 2007-11-28 | 2013-12-25 | 联邦科学和工业研究组织 | Nanoemulsions |
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