CN110236988A - A kind of antiallergic is releived multiple remediation composition and its ointment and preparation method - Google Patents
A kind of antiallergic is releived multiple remediation composition and its ointment and preparation method Download PDFInfo
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- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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Abstract
It releives multiple remediation composition and its ointment and preparation method the invention discloses a kind of antiallergic, it is desirable to provide a kind of skin sense is splendid, is damaged skin to sensibility and has to releive and repairs the composition and ointment of moisten effect；Its technical solution mainly includes following components: 13~20 parts of jojoba oil, 25~35 parts of atoleine, 6~15 parts of saualane, 7~12 parts of microwax, 1~2 part of paraffin, 5~9 parts of beeswax, 1~3 part of polyethylene, 1~3 part of caprylic/capric triglyceride, 0.1~2 part of natural tocopherol, 0.1~1 part of red myrrh alcohol, 1~3 part of puncture vine berry extract, 1~3 part of oil of plantain blueweed seed, 1~3 part of chrysanthemum extract, ampelopsis grossdentata leaf extracts 0.3~1 part, 0.3~1 part of sunflower seed oil unsaponifiable matter, 0.2~0.8 part of sunflower seed oil, 0.2~0.8 part of cape jasmine flower extract, 0.1~0.7 part of purple common perilla seed, 0.1~0.7 part of grape seed extract, 0.1~0.7 part of mung bean seed extract；Belong to cosmetic technical field.
Description
Technical field
The invention discloses a kind of compositions, specifically, being that a kind of antiallergic is releived multiple remediation composition, the present invention is also
The antiallergic of the public the composition is releived the multiple preparation method for repairing ointment and the ointment, and cosmetic technical field is belonged to.
Background technique
Sensitive skin, a kind of overreaction of skin, some external environment factors are drawn including hard water and cosmetics
The excessive sensory reaction of the skin risen.The formation of sensitive skin may be related with following factor: 1, skin barrier is impaired, thorn
Swash object and enter skin more easily by impaired cuticula, causes inflammatory reaction；2, cutaneous nerve signal transduction is amplified extremely, quick
Nerve growth content in sense keratoderma is higher than normal skin, therefore slight stimulation will cause sensitive skin
Abnormal response；3, inflammatory reaction, the characteristics of due to above-mentioned two factor, sensitive skin is easy by after the invasion of environmental stimuli object
Inflammatory reaction is generated, inflammatory reaction can further damage skin barrier and cutaneous nerve, lead to vicious circle.Skin irritatin and mistake
Quick is all sensitive skin by the reaction after environmental stimuli, seasonal shift, cosmetics abuse, plant (pollen), ultraviolet light, cold wind
Etc. extraneous factors all may be cause sensitive skin stimulate or allergy factor.
With external environment worse and worse, increasingly increased operating pressure and hormone are led in the abuse of skin surface
A possibility that sensitization perception skin occurs increase, extraneous stimulant drive straight in inside skin, cause the inflammation such as stimulation or allergy
Disease reaction.Therefore added in the formula of cosmetics natural antiallergic releive repair skin effect active components of plants, not only may be used
To mitigate the inflammatory reactions such as skin irritatin or allergy, and the barrier of skin damage is repaired, improves the state of skin from the root,
Achieve the effect that conditioning skin.
(such as hormone face cures skin etc. after the fine arts) the uncomfortable reaction such as usually will appear heat, pain, itch after skin damage, together
When be destroyed with skin barrier, the symptoms such as the general red, pigmentation of skin, easy allergy, most of antiallergics, which are releived, repairs skin original
The addition of material only resides in the level of " conceptual " addition, or only helpful to immediate allergic skin, but to impaired
The conditioning of skin is unable to reach desired effect.And these antiallergics releive that repair skin raw material be mostly that alcohol is molten or water-soluble, be difficult into
Enter to inside fat-soluble skin.Ointment is to be applied to human skin surface, has a kind of product for moistening and protecting skin, at present
Rarely has appearance for the ointments product of impaired skin in the market.
Summary of the invention
In view of the above-mentioned problems, the first purpose of the invention is to provide it is a kind of it is affine do not stimulate, mildly releive, antiallergic it is anti-
Composition that is scorching, repairing impaired skin effect.
A second object of the present invention is to provide a kind of safe and non-stimulating, skin sense is splendid, is easy to percutaneous absorption, to sensibility
Impaired skin have well releive, repair, the ointment of moisten effect.
Third object of the present invention is to provide the preparation methods of above-mentioned ointment.
For this purpose, first technical solution provided by the invention is such that
A kind of antiallergic is releived multiple remediation composition, including following components in parts by weight: 13~20 parts of jojoba oil, puncture vine
1~3 part of berry extract, 1~3 part of oil of plantain blueweed seed, 1~3 part of chrysanthemum extract, ampelopsis grossdentata leaf extracts 0.3~1
Part, it is 0.3~1 part of sunflower seed oil unsaponifiable matter, 0.2~0.8 part of sunflower seed oil, 0.2~0.8 part of cape jasmine flower extract, purple
0.1~0.7 part of Perillaseed extract, 0.1~0.7 part of grape seed extract, 0.1~0.7 part of mung bean seed extract.
As present invention further optimization, it further includes that nutmeg benevolence mentions that above-mentioned antiallergic, which is releived multiple remediation composition,
Take 1.5~2.5 parts of object, 1.5~2.5 parts of cardiospermum halicacabum flower/leaf/boisiana extract, Mosla chinensis/0.2~0.7 part of leaf/stem extraction,
0.2~0.6 part of Fructus Kochiae extract, ampelopsis grossdentata leaf extracts 0.1~0.6 part, 0.1~0.6 part of peony extract.
As present invention further optimization, above-mentioned antiallergic is releived multiple remediation composition, further includes that safflower flower mentions
Take 1~2 part of object, 0.2~0.8 part of fructus arctii seed extract, 0.1~0.6 part of Schisandra fruit extract, Flos Mume extract 0.1~0.5
Part.
As present invention further optimization, above-mentioned antiallergic is releived multiple remediation composition, and the antiallergic is releived
Multiple remediation composition is made of following components in parts by weight；15~18 parts of jojoba oil, 1.2~2.6 parts of puncture vine berry extract,
1.5~2.4 parts of oil of plantain blueweed seed, 1.5~2 parts of chrysanthemum extract, ampelopsis grossdentata leaf extracts 0.5~0.8 part, sunflower
0.3~0.8 part of seed oil unsaponifiable matter, 0.3~0.5 part of sunflower seed oil, 0.3~0.5 part of cape jasmine flower extract, purple perilla seed is extracted
0.2~0.6 part of object, 0.2~0.5 part of grape seed extract, 0.3~0.5 part of mung bean seed extract, nutmeg benevolence extract 1.8
~2.2 parts, 1.8~2.2 parts of cardiospermum halicacabum flower/leaf/boisiana extract, Mosla chinensis/0.3~0.6 part of leaf/stem extraction, the fruit of summer cypress
0.3~0.5 part of extract, 0.2~0.5 part of ampelopsis grossdentata leaf extraction, 0.2~0.4 part of peony extract, safflower flower extract
1.2~1.8 parts, 0.3~0.6 part of fructus arctii seed extract, 0.2~0.5 part of Schisandra fruit extract, Flos Mume extract 0.2~0.4
Part.
Second technical solution provided by the invention is such that
A kind of antiallergic is releived the ointment of multiple reparation, including following components, and 6~15 parts of saualane, 5~9 parts of beeswax, liquid
25~35 parts of paraffin, 7~12 parts of microwax, 1~2 part of paraffin, 1~3 part of polyethylene, 0.1~2 part of tocopherol, bisabolol 0.1
~1 part, 0.5~1.5 part of octyl dodecanol, 0.1~3 part of hexyl decyl alcohol, N~palmityl hydroxy-proline cetyl 0.1~1
Part, 0.1~0.5 part of stearic acid, 0.1~0.5 part of campesterol class, 1~3 part of caprylic/capric triglyceride, Butylated Hydroxytoluene 0.1
Part, 0.1~1 part of lecithin, 0.1~2 part of natural tocopherol, 0.1~1 part of red myrrh alcohol, 13~20 parts of jojoba oil, puncture vine fruit
1~3 part of extract, 1~3 part of oil of plantain blueweed seed, 1~3 part of chrysanthemum extract, ampelopsis grossdentata leaf extracts 0.3~1 part,
0.3~1 part of sunflower seed oil unsaponifiable matter, 0.2~0.8 part of sunflower seed oil, 0.2~0.8 part of cape jasmine flower extract, purple perilla seed
0.1~0.7 part of extract, 0.1~0.7 part of grape seed extract, 0.1~0.7 part of mung bean seed extract.
Further, a kind of above-mentioned antiallergic is releived the ointment of multiple reparation, including following components, and 6~15 parts of saualane,
5~9 parts of beeswax, 25~35 parts of atoleine, 7~12 parts of microwax, 1~2 part of paraffin, 1~3 part of polyethylene, tocopherol 0.1~
2 parts, 0.1~1 part of bisabolol, 0.5~1.5 part of octyl dodecanol, 0.1~3 part of hexyl decyl alcohol, N~palmityl hydroxyl dried meat ammonia
0.1~1 part of sour cetyl, 0.1~0.5 part of stearic acid, 0.1~0.5 part of campesterol class, caprylic/capric triglyceride 1~3
Part, 0.1 part of Butylated Hydroxytoluene, 0.1~1 part of lecithin, 0.1~2 part of natural tocopherol, 0.1~1 part of red myrrh alcohol, jojoba oil
13~20 parts, 1~3 part of puncture vine berry extract, 1~3 part of oil of plantain blueweed seed, 1~3 part of chrysanthemum extract, ampelopsis grossdentata
0.3~1 part of leaf extraction, 0.3~1 part of sunflower seed oil unsaponifiable matter, 0.2~0.8 part of sunflower seed oil, cape jasmine flower extract
0.2~0.8 part, 0.1~0.7 part of purple common perilla seed, 0.1~0.7 part of grape seed extract, mung bean seed extract 0.1~0.7
Part, 1.5~2.5 parts of nutmeg benevolence extract, 1.5~2.5 parts of cardiospermum halicacabum flower/leaf/boisiana extract, Mosla chinensis/leaf/stem extracts
0.2~0.7 part of object, 0.2~0.6 part of Fructus Kochiae extract, ampelopsis grossdentata leaf extracts 0.1~0.6 part, peony extract 0.1
~0.6 part.
Further, a kind of above-mentioned antiallergic is releived the ointment of multiple reparation, including following components, and 6~15 parts of saualane,
5~9 parts of beeswax, 25~35 parts of atoleine, 7-12 parts of microwax, 1~2 part of paraffin, 1~3 part of polyethylene, tocopherol 0.1~2
Part, 0.1~1 part of bisabolol, 0.5~1.5 part of octyl dodecanol, 0.1~3 part of hexyl decyl alcohol, N~palmityl hydroxy-proline
0.1~1 part of cetyl, 0.1~0.5 part of stearic acid, 0.1~0.5 part of campesterol class, 1~3 part of caprylic/capric triglyceride,
0.1 part of Butylated Hydroxytoluene, 0.1~1 part of lecithin, 0.1~2 part of natural tocopherol, 13~20 parts of jojoba oil, puncture vine berry extract
1~3 part, 1~3 part of oil of plantain blueweed seed, 1~3 part of chrysanthemum extract, ampelopsis grossdentata leaf extracts 0.3~1 part, sunflower
0.3~1 part of seed oil unsaponifiable matter, 0.2~0.8 part of sunflower seed oil, 0.2~0.8 part of cape jasmine flower extract, purple common perilla seed
0.1~0.7 part, 0.1~0.7 part of grape seed extract, 0.1~0.7 part of mung bean seed extract, nutmeg benevolence extract 1.5~
2.5 parts, 1.5~2.5 parts of cardiospermum halicacabum flower/leaf/boisiana extract, Mosla chinensis/0.2~0.7 part of leaf/stem extraction, the fruit of summer cypress mentions
Taking 0.2~0.6 part of object, ampelopsis grossdentata leaf extracts 0.1~0.6 part, and 0.1~0.6 part of peony extract, safflower flower extract 1
~2 parts, 0.2~0.8 part of fructus arctii seed extract, 0.1~0.6 part of Schisandra fruit extract, 0.1~0.5 part of Flos Mume extract.
Further, a kind of above-mentioned antiallergic is releived the ointment of multiple reparation, including following components, and 6~15 parts of saualane,
5~9 parts of beeswax, 25~35 parts of atoleine, 7-12 parts of microwax, 1~2 part of paraffin, 1~3 part of polyethylene, tocopherol 0.1~2
Part, 0.1~1 part of bisabolol, 0.5~1.5 part of octyl dodecanol, 0.1~3 part of hexyl decyl alcohol, N~palmityl hydroxy-proline
0.1~1 part of cetyl, 0.1~0.5 part of stearic acid, 0.1~0.5 part of campesterol class, 1~3 part of caprylic/capric triglyceride,
0.1 part of Butylated Hydroxytoluene, 0.1~1 part of lecithin, 0.1~2 part of natural tocopherol, 0.1~1 part of red myrrh alcohol, jojoba oil 15~
18 parts, 1.2~2.6 parts of puncture vine berry extract, 1.5~2.4 parts of oil of plantain blueweed seed, 1.5~2 parts of chrysanthemum extract, show tooth
0.5~0.8 part of porcelain ampelopsis leaf extraction, 0.3~0.8 part of sunflower seed oil unsaponifiable matter, 0.3~0.5 part of sunflower seed oil, cape jasmine
0.3~0.5 part of flower extract, 0.2~0.6 part of purple common perilla seed, 0.2~0.5 part of grape seed extract, mung bean seed extract
0.3~0.5 part, 1.8~2.2 parts of nutmeg benevolence extract, 1.8~2.2 parts of cardiospermum halicacabum flower/leaf/boisiana extract, Mosla chinensis/
0.3~0.6 part of leaf/stem extraction, 0.3~0.5 part of Fructus Kochiae extract, ampelopsis grossdentata leaf extracts 0.2~0.5 part, tree peony
0.2~0.4 part of extract, 1.2~1.8 parts of safflower flower extract, 0.3~0.6 part of fructus arctii seed extract, Schisandra fruit extract
0.2~0.5 part, 0.2~0.4 part of Flos Mume extract.
Third technical solution provided by the invention be to provide above-mentioned antiallergic releive multiple reparation ointment preparation side
Method successively includes the following steps:
1) jojoba oil, saualane, beeswax, atoleine, microwax, paraffin are weighed, polyethylene is added in beaker,
It is put into 80~85 DEG C of thermostat water bath and heats, it is stand-by as solution a；
2) surplus materials is weighed, is added in beaker, beaker is put into 55~60 DEG C of water-baths, it is stand-by as solution b；
3) when the temperature of solution a, solution b reach 55~60 DEG C simultaneously, the drainage of solution b glass bar is slowly added into molten
It is stirring while adding in liquid a, ointment is repaired until forming uniform ointment and releiving to get antiallergic.
Compared with prior art, technical solution provided by the invention has following technological merit:
1, technical solution provided by the invention is using jojoba oil as main component, jojoba oil have outstanding moisturizing and
Soothing effect, effectively maintenance skin elasticity, remove dry line, prevent skin ageing, have outstanding relaxation effect to quick skin is done, then
Compatibility puncture vine berry extract, plantain blueweed seed oil, chrysanthemum extract, ampelopsis grossdentata leaf extract, and sunflower seed oil is not saponified
Object, sunflower seed oil, cape jasmine flower extract, purple common perilla seed, grape seed extract and mung bean seed extract restrain nuisance
The intrusion of matter, avoids skin allergy；Enhance adhesion strength between keratinocyte, improves the symptoms such as dry skin, furfur, coarse；Especially
It has apparent antibacterial action to gold-coloured staphylococci, bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa etc., can obviously press down
Capillary permeability caused by histamine processed increases, and alleviates pruritis caused by histamine, plays antianaphylactic effect；Also,
Inhibit 5- lipoxygenase, skin barrier is consolidated in enhancing, and the excess moisture for fighting skin is lost；Increase epidermal keratinocytes thickness simultaneously
Degree increases skin elasticity, delay skin aging；To reach inhibition stimulation, skin of releiving increases elasticity of skin, antibacterial, antioxygen
Change, anti-inflammatory, antiallergic of releiving, moisture-keeping efficacy.
2, the components such as technical solution jojoba oil provided by the invention compound nutmeg benevolence extract, cardiospermum halicacabum flower/leaf/rattan
Extract, Mosla chinensis/leaf/stem extraction, Fructus Kochiae extract, ampelopsis grossdentata leaf extracts and peony extract, passes through suppression
Phospholipase A2 and cyclooxygenase-2 processed reduce inflammation and allergic reaction, further promote skin wound healing, enhance immune function
The pharmacological actions such as energy, anti-inflammatory, analgesia, promoting blood circulation and cooling blood, wind-dispelling heat-dissipating, nourishing Yin and promoting production of body fluid play skin discomfort reaction of releiving, promote flesh
The effect of skin reparation.
3, the components such as technical solution jojoba oil provided by the invention compounding safflower flower extract, fructus arctii seed extract, five
Taste berry extract, Flos Mume extract, further calmness skin, and the transmitting of inflammatory factor can be inhibited, increase anti-oxidant
Effect removes the effect of free radical and anti-lipid peroxidation, and skin can be made to resist free radical infringement, prevent the oxidation of sebum film
The effect of damage promotes skin to complete self-regeneration, above effect object is concentrated one's attention on compatibility, plays removing toxic substances, antipruritic, detumescence, repairs.
The homeostasis of skin is maintained, skin barrier is strengthened, skin antioxidant system is maintained to run well.
4, the natural antiallergic of ointment provided by the invention, which is releived, repairs the active components of plants of skin effect, can not only mitigate
The inflammatory reactions such as skin irritatin or allergy, easily enter inside skin, repair the barrier of skin damage, improve skin from the root
State, achieve the effect that conditioning skin.
5, ointment provided by the invention has the characteristics that following skin sense, and native waxy lotion, ductility is good, easily pushes easy painting open
It smears, skin sense is soft and moist, soft and smooth, and the mild pro-skin of use process, docile, soothing effect is extremely strong, there is very strong moisture feeling after use.
Specific embodiment
The following is a clear and complete description of the technical scheme in the embodiments of the invention, it is clear that described embodiment
Only a part of the embodiments of the present invention, rather than whole embodiments.For not specifically specified technological parameter or condition,
It can refer to routine techniques progress.
Embodiment 1
A kind of antiallergic provided by the invention is releived multiple remediation composition, the component including following weight number: jojoba oil
20g, puncture vine berry extract 1g, plantain blueweed seed oil 3g, chrysanthemum extract 1g, ampelopsis grossdentata leaf extraction 1g, sunflower seed
Oily unsaponifiable matter 0.3g, sunflower seed oil 0.8g, cape jasmine flower extract 0.2g, purple common perilla seed 0.7g, grape seed extract
0.1g, mung bean seed extract 0.7g.
Embodiment 2
A kind of antiallergic provided by the invention is releived multiple remediation composition, the component including following weight number: jojoba oil
13g, puncture vine berry extract 3g, plantain blueweed seed oil 1g, chrysanthemum extract 3g, ampelopsis grossdentata leaf extraction 0.3g, sunflower
Seed oil unsaponifiable matter 1g, sunflower seed oil 0.2g, cape jasmine flower extract 0.8g, purple common perilla seed 0.1g, grape seed extract
0.7g, mung bean seed extract 0.1g.
Embodiment 3
A kind of antiallergic provided by the invention is releived multiple remediation composition, the component including following weight number: jojoba oil
15g, puncture vine berry extract 2g, plantain blueweed seed oil 2g, chrysanthemum extract 2g, ampelopsis grossdentata leaf extraction 0.5g, sunflower
Seed oil unsaponifiable matter 0.6g, sunflower seed oil 0.4g, cape jasmine flower extract 0.6g, purple common perilla seed 0.3g, grape pip extract
Object 0.2g, mung bean seed extract 0.6g, nutmeg benevolence extract 2g, cardiospermum halicacabum flower/leaf/boisiana extract 2g, Mosla chinensis/leaf/
Stem extraction 0.5g, Fructus Kochiae extract 0.3g, ampelopsis grossdentata leaf extract 0.2g, peony extract 0.3g.
Embodiment 4
A kind of antiallergic provided by the invention is releived multiple remediation composition, the component including following weight number: jojoba oil
14g, puncture vine berry extract 1.5g, plantain blueweed seed oil 1.5g, chrysanthemum extract 1.6g, ampelopsis grossdentata leaf extraction 0.7g,
Sunflower seed oil unsaponifiable matter 0.6g, sunflower seed oil 0.6g, cape jasmine flower extract 0.4g, purple common perilla seed 0.5g, grape
Seed extract 0.5g, mung bean seed extract 0.6g, nutmeg benevolence extract 1.8g, cardiospermum halicacabum flower/leaf/boisiana extract 1.7g, stone
Chinese mosla flower/leaf/stem extraction 0.3g, Fructus Kochiae extract 0.4g, ampelopsis grossdentata leaf extract 0.4g, peony extract 0.3g.
Embodiment 5
A kind of antiallergic provided by the invention is releived multiple remediation composition, the component including following weight number: jojoba oil
17g, puncture vine berry extract 2.5g, plantain blueweed seed oil 1.8g, chrysanthemum extract 1.7g, ampelopsis grossdentata leaf extraction 0.7g,
Sunflower seed oil unsaponifiable matter 0.6g, sunflower seed oil 0.6g, cape jasmine flower extract 0.4g, purple common perilla seed 0.6g, grape
Seed extract 0.5g, mung bean seed extract 0.6g, nutmeg benevolence extract 1.8g, cardiospermum halicacabum flower/leaf/boisiana extract 1.7g, stone
Chinese mosla flower/leaf/stem extraction 0.3g, Fructus Kochiae extract 0.4g, ampelopsis grossdentata leaf extract 0.4g, peony extract 0.3g,
Safflower flower extract 1g, fructus arctii seed extract 0.8g, Schisandra fruit extract 0.1g, Flos Mume extract 0.5g.
Embodiment 6
A kind of antiallergic provided by the invention is releived multiple remediation composition, the component including following weight number: jojoba oil
17g, puncture vine berry extract 2g, plantain blueweed seed oil 1.8g, chrysanthemum extract 1.2g, ampelopsis grossdentata leaf extraction 0.6g, to
Day seed oil of sunflower unsaponifiable matter 0.4g, sunflower seed oil 0.5g, cape jasmine flower extract 0.6g, purple common perilla seed 0.2g, grape pip
Extract 0.4g, mung bean seed extract 0.5g, nutmeg benevolence extract 2.5g, cardiospermum halicacabum flower/leaf/boisiana extract 1.5g, Shi Xiang
Ru flower/leaf/stem extraction 0.7g, Fructus Kochiae extract 0.2g, ampelopsis grossdentata leaf extracts 0.6g, peony extract 0.1g, red
Flower flower extract 2g, fructus arctii seed extract 0.2g, Schisandra fruit extract 0.6g, Flos Mume extract 0.1g.
Embodiment 7
A kind of antiallergic provided by the invention is releived multiple remediation composition, is grouped as by the group of following weight number；Flash
Bar oil 18g, puncture vine berry extract 1.2g, plantain blueweed seed oil 2.4g, chrysanthemum extract 1.5g, ampelopsis grossdentata leaf extract
0.8g, sunflower seed oil unsaponifiable matter 0.3g, sunflower seed oil 0.5g, cape jasmine flower extract 0.3g, purple common perilla seed 0.6g,
Grape seed extract 0.2g, mung bean seed extract 0.5g, nutmeg benevolence extract 1.8g, cardiospermum halicacabum flower/leaf/boisiana extract
2.2g, Mosla chinensis/leaf/stem extraction 0.3g, Fructus Kochiae extract 0.5g, ampelopsis grossdentata leaf extract 0.2g, and tree peony is extracted
Object 0.4g, safflower flower extract 1.2g, fructus arctii seed extract 0.6g, Schisandra fruit extract 0.2g, Flos Mume extract 0.4g.
Embodiment 8
A kind of antiallergic provided by the invention is releived multiple remediation composition, is grouped as by the group of following weight number；Flash
Bar oil 15g, puncture vine berry extract 2.6g, plantain blueweed seed oil 1.5g, chrysanthemum extract 2g, ampelopsis grossdentata leaf extract
0.5g, sunflower seed oil unsaponifiable matter 0.8g, sunflower seed oil 0.3g, cape jasmine flower extract 0.5g, purple common perilla seed 0.2g,
Grape seed extract 0.5g, mung bean seed extract 0.3g, nutmeg benevolence extract 2.2g, cardiospermum halicacabum flower/leaf/boisiana extract
1.8g, Mosla chinensis/leaf/stem extraction 0.6g, Fructus Kochiae extract 0.3g, ampelopsis grossdentata leaf extract 0.5g, and tree peony is extracted
Object 0.2g, safflower flower extract 1.8g, fructus arctii seed extract 0.3g, Schisandra fruit extract 0.5g, Flos Mume extract 0.2g.
Embodiment 9
Antiallergic provided by the invention is releived multiple reparation ointment, is made of the following components: saualane 15g, beeswax 5g, liquid
Paraffin 35g, microwax 7g, paraffin 2g, polyethylene 1g, tocopherol 2g, bisabolol 0.1g, octyl dodecanol 1.5g, the hexyl last of the ten Heavenly stems
Alcohol 0.1g, N~palmityl hydroxy-proline cetyl 1g, stearic acid 0.1g, campesterol class 0.5g, caprylic/capric glycerol three
Antiallergic in ester 1g, Butylated Hydroxytoluene 0.1g, lecithin 1g and embodiment 1 is releived multiple remediation composition.
Embodiment 10
Antiallergic provided by the invention is releived multiple reparation ointment, is made of the following components: saualane 6g, beeswax 9g, liquid
Paraffin 25g, microwax 12g, paraffin 1g, polyethylene 3g, tocopherol 0.1g, bisabolol 1g, octyl dodecanol 0.5g, the hexyl last of the ten Heavenly stems
Alcohol 3g, N~palmityl hydroxy-proline cetyl 0.1g, stearic acid 0.5g, campesterol class 0.1g, caprylic/capric glycerol three
Antiallergic in ester 3g, Butylated Hydroxytoluene 0.1g, lecithin 0.1g and embodiment 3 is releived multiple remediation composition.
Embodiment 11
Antiallergic provided by the invention is releived multiple reparation ointment, is made of the following components: saualane 10g, beeswax 7g, liquid
Paraffin 30g, microwax 9g, paraffin 1.2g, polyethylene 2g, tocopherol 1g, bisabolol 0.5g, octyl dodecanol 1g, the hexyl last of the ten Heavenly stems
Alcohol 1.2g, N~palmityl hydroxy-proline cetyl 0.5g, stearic acid 0.3g, campesterol class 0.2g, caprylic/capric glycerol
Antiallergic in three ester 1.2g, Butylated Hydroxytoluene 0.1g, lecithin 0.3g and embodiment 5 is releived multiple remediation composition.
Embodiment 12
Antiallergic provided by the invention is releived multiple reparation ointment, is made of the following components: saualane 10g, beeswax 6g, liquid
Paraffin 28g, microwax 10g, paraffin 1.5g, polyethylene 1.8g, tocopherol 0.8g, bisabolol 0.6g, octyl dodecanol 0.4g,
Hexyl decyl alcohol 0.6g, N~palmityl hydroxy-proline cetyl 0.4g, stearic acid 0.2g, campesterol class 0.3g, the octanoic acid/last of the ten Heavenly stems
Antiallergic in acid glycerol three ester 1.5g, Butylated Hydroxytoluene 0.1g, lecithin 0.6g and embodiment 7 is releived multiple remediation composition.
Antiallergic described in embodiment 9 to 12 releive it is multiple repair ointment preparation method, successively include the following steps:
1) jojoba oil, saualane, beeswax, atoleine, micro- is weighed according to any one group of mass number in embodiment 9 to 12
Brilliant wax, paraffin, polyethylene are added in beaker, are put into 80~85 DEG C of thermostat water bath and are heated, stand-by as solution a；
2) it weighs remaining component to be added in beaker, beaker is put into 55~60 DEG C of water-baths, it is stand-by as solution b；
3) when the temperature of solution a, solution b reach 55~60 DEG C simultaneously, the drainage of solution b glass bar is slowly added into molten
It is stirring while adding in liquid a, ointment is repaired until forming uniform ointment and releiving to get antiallergic.
In order to prove the effect of offer ointment of the invention, below by the ointment being prepared in present example 9-12 and
Comparative experiments 1-6 carries out the test assessment of chorioallantoic membrane blood vessel:
Comparative experiments 1: other components are as embodiment 12, the difference is that spending atoleine replaces Jojoba
Oil.
Comparative experiments 2: other components are as embodiment 12, the difference is that combining without releive multiple reparations of antiallergic
Object.
Comparative experiments 3: other components are as embodiment 12, the multiple remediation composition the difference is that antiallergic is releived
Containing jojoba oil.
The proof test of skin repair skin ointment is repaired in order to prove that antiallergic provided by the invention is releived:
(1) test method is sketched:
Chorioallantoic membrane blood vessel tests the side (Chorioallantoic membrane vascular assay, CAMVA)
Method, to the potential eye irritation of the evaluation of effect of blood vessel, takes 14 days instar chicken embryos, tested material directly contacts CAM by observation tested material
Small region, CAM Vascular change is observed after exposure 30 minutes, such as bleeding or hyperemia (telangiectasis), blood vessel disappear
(ghost blood vessel), make 50% fertilized eggs occur these damage tested material concentration be considered as toxic endpoints.CAMVA test needs
It measures 10 and 50% positive reaction dosage achieved occurs for examination chicken embryo.
(2) result judgement standard:
Table 1-1 CAMVA test scores standard
(3) test result:
Table 1-2 cosmetics irritation (CAMVA test) result judgement standard
(4) analysis of results table 1-3 ointment AMVA experimental test result
It is found that the CAMVA test positive rate of available ointment of the present invention is 10% hereinafter, average integral from table 1-3
Below 0.5；The CAMVA test positive rate of comparative experiments 1,2 and 3 is greater than 55%, and average integral is all larger than 1.64.According to judgement
Standard scale 1, irritation (safety) test result of embodiment 1-3 are " qualification ", the irritation (safety) of comparative experiments 1-3
Test result is " " unqualified ".It follows that the extracts such as jojoba oil have effects that antiallergic reparation.
2, skin irritation/corrosion test
2.1 test methods and result judgement standard reference: Ministry of Health of the People's Republic of China's " cosmetics safety technical specification
(2015)-the 6 chapter Section 4 skin irritations/corrosion test ".
Rabbit is divided into skin injury and two groups not damaged, every group 4, half male and half female, vertebra two sides unhairing, skin injury
Group Sandpapering, until slight bleeding occurs in skin, not damaged group is not processed.0.5g ointment is taken to be applied to right side skin
On, left side is smeared with 0.5g physiological saline and is compareed, and is fixed with non-stimulated bandage.Residual ointment is removed with warm water after 4h.Observation
1,24,48 and 72h smears position dermoreaction after removing ointment, dermoreaction scoring is carried out by table 2-1, according to 24,48 and 72h
Each observation time point top mean value, determines skin irritatin intensity by table 2-2.
The scoring of table 2-1 skin wound repair
| Dermoreaction | Integral |
| Erythema and eschar are formed | |
| Without erythema | 0 |
| Slight erythema (visible reluctantly) | 1 |
| Obvious erythema | 2 |
| Moderate-severe erythema | 3 |
| Severe erythema (aubergine) to micro- eschar is formed | 4 |
| Oedema is formed | |
| Without oedema | 0 |
| Slight oedema (visible reluctantly) | 1 |
| Mild edema (cutaneous protuberance is clearly outlined) | 2 |
| Intermediate edema (cutaneous protuberance about 1mm) | 3 |
| Severe edema (cutaneous protuberance is more than 1mm, and range expands) | 4 |
| Top | 8 |
2-2 skin irritatin strength grading
| Integral mean value | Intensity |
| 0- < 0.5 | It is nonirritant |
| 0.5- < 2.0 | Subexcite |
| 2.0- < 6.0 | Moderate stimulation |
| 6.0-8.0 | Strong and stimulating |
2.2 experimental results and analysis
The skin irritation test result of table 2-3 ointment
By the result of table 2-3 it is found that damaged in embodiment 9-12 and non-damaged skin the left and right sides in different time points
Do not occur erythema, oedema, it is 0 that ointment, which tests two groups of skin irritation scoring score values, and ointment is tested in comparative experiments 1 and 3
It as a result is minimal irritation, ointment test result is moderate stimulation in comparative experiments 2.It follows that the extracts such as jojoba oil
Has effects that antiallergic reparation.
3, cutaneous anaphylaxis is tested
3.1 test methods and result judgement standard
SD rat is randomly divided into blank group, positive controls and ointment group, every group 8, half male and half female.By rat back
Left and right sides depilation, blank group smear 0.5g physiological saline, and positive controls smear 0.5g 2,4- dinitrofluorobenzene (is matched with acetone
Be set to 1% concentration), ointment group smear 0.5g ointment, fixed with non-stimulated gauze, continue 6h, the next day sensitization it is primary, totally 3 times.Most
Afterwards 7 days after a sensitization, without hair-fields on the left of rat back, blank group smears 0.5g physiological saline, and positive controls are smeared
0.5g 2,4- dinitrofluorobenzene (being configured to 1% concentration with acetone), ointment group are smeared 0.5g ointment, are fixed with non-stimulated gauze,
Tested material is washed away after 6h, observes 24,48 and 72h cutaneous anaphylaxis situation.
By the allergy score value of table 3-1 record different time points, it is calculated according to the following formula
Reaction average value=(erythema forms sum+oedema and forms total score)/total number of animals
Sensitization (sensitization incidence=have allergic reaction number of rats/rat is inferred by sensitization incidence by the standard of table 3-2
Total * 100%).Observe whether rat there are the severe reactions such as astasia, shock, asthma simultaneously.
Table 3-1
Table 3-2 hypersensitive evaluation criterion
| Sensitization incidence (%) | Hypersensitive evaluation |
| 0-10 | Without sensitization |
| 11-30 | Slight sensitization |
| 31-60 | Moderate sensitization |
| 61-80 | Height sensitization |
| 81-100 | Extreme sensitization |
3.2 experimental results and analysis
The skin hypersensitivity experimental result of table 3-3 ointment
By the result of table 3-3 it is found that positive controls have stronger sensitization to skin, embodiment 9-12 is to skin without cause
Quick property, during ointment sensitization has reached in comparative experiments 1-3 or height.It follows that the extracts such as jojoba oil have antiallergic
The effect of reparation.
4, human skin patch
4.1 test methods and result judgement standard reference: Ministry of Health of the People's Republic of China's " cosmetics safety technical specification
(2015)-the 7 chapter Section 2 human skin patch "
30 Eligible subjects are screened, 0.025g ointment are put into 30 square millimeters, 1 millimeter of depth of spot tester cell
It is interior.Control wells are blank.The forearm song side of subject will be attached at muting sensitive adhesive tape added with the spot tester of ointment, be gently pressed with palm
It is allowed to equably be pasted on skin, continue for 24 hours.After removal ointment examination device after 30min, marked for 24 hours with 48h by table 4-1
Quasi- observation dermoreaction.
Table 4-1 skin closure type patch test reacts grade scale
4.2 experimental results and analysis
Table 4-2 ointment patch test results
| Sample | Grading system |
| Embodiment 9 | 0 |
| Embodiment 10 | 0 |
| Embodiment 11 | 0 |
| Embodiment 12 | 0 |
| Comparative experiments 1 | 1 |
| Comparative experiments 2 | 1 |
| Comparative experiments 3 | 2 |
By the result of table 4-2 it is found that the grading system of each embodiment is 0, dermoreaction is negative reaction, and comparison is real
The grading system for testing 1,2 and 3 is respectively 1,1 and 2, and the extracts such as jojoba oil described above have effects that antiallergic reparation.
5, sensory evaluation
5.1 experimental methods: recruiting 18 valuation officers, be sensitive flesh, have higher tactile sensativity and accuracy, good
Good ability to express, can objectively evaluate cosmetic sample feature.Organoleptic analysis's laboratory temperature is maintained at 20-22
DEG C, relative humidity is maintained at 40-60%.Everyone takes 0.5g ointment to be applied to left cheek, with left index finger finger tip by clockwise
It is applied to and fully absorbs, and the skin sense in stage each during smearing is evaluated, marking system 0-5, the average value of valuation officer is made
For the score value of index.
5.2 results and analysis
The Analyses Methods for Sensory Evaluation Results of table 5-1 embodiment 9,10,11 and 12
By table 5-1 it is found that atoleine, saualane, microwax, paraffin, beeswax, polyethylene, caprylic/capric glycerol three
Ester, jojoba oil are arranged in pairs or groups according to a certain percentage, and available patch skin degree is good, absorb fast, glossy weak product.By comparative experiments 1-
3 evaluation is it is found that puncture vine berry extract, plantain blueweed seed oil, the extracts such as sunflower seed oil unsaponifiable matter not only have anti-
Quick the effect of repairing of releiving, and its additive amount affects the skin sense evaluation index of ointment.
The above embodiment is a preferred embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment
Limitation, other any changes, modifications, substitutions, combinations, simplifications made without departing from the spirit and principles of the present invention,
It should be equivalent substitute mode, be included within the scope of the present invention.
Claims (6)
- The multiple remediation composition 1. a kind of antiallergic is releived, which is characterized in that including following components in parts by weight: jojoba oil 13~ 20 parts, 1~3 part of puncture vine berry extract, 1~3 part of oil of plantain blueweed seed, 1~3 part of chrysanthemum extract, ampelopsis grossdentata leaf mentions Take 0.3~1 part, 0.3~1 part of sunflower seed oil unsaponifiable matter, 0.2~0.8 part of sunflower seed oil, cape jasmine flower extract 0.2~ 0.8 part, 0.1~0.7 part of purple common perilla seed, 0.1~0.7 part of grape seed extract, 0.1~0.7 part of mung bean seed extract.
- The multiple remediation composition 2. antiallergic according to claim 1 is releived, which is characterized in that further include that nutmeg benevolence is extracted 1.5~2.5 parts of object, 1.5~2.5 parts of cardiospermum halicacabum flower/leaf/boisiana extract, Mosla chinensis/0.2~0.7 part of leaf/stem extraction, ground 0.2~0.6 part of skin seed extract, ampelopsis grossdentata leaf extracts 0.1~0.6 part, 0.1~0.6 part of peony extract.
- The multiple remediation composition 3. antiallergic according to claim 2 is releived, which is characterized in that further include that safflower flower extracts 1~2 part of object, 0.2~0.8 part of fructus arctii seed extract, 0.1~0.6 part of Schisandra fruit extract, Flos Mume extract 0.1~0.5 Part.
- The multiple remediation composition 4. antiallergic according to claim 3 is releived, which is characterized in that the antiallergic is releived more Reconditioning compound composition is made of following components in parts by weight；15~18 parts of jojoba oil, 1.2~2.6 parts of puncture vine berry extract, vehicle 1.5~2.4 parts of oil of frontal lobe blueweed seed, 1.5~2 parts of chrysanthemum extract, ampelopsis grossdentata leaf extracts 0.5~0.8 part, sunflower seed 0.3~0.8 part of oily unsaponifiable matter, 0.3~0.5 part of sunflower seed oil, 0.3~0.5 part of cape jasmine flower extract, purple common perilla seed 0.2~0.6 part, 0.2~0.5 part of grape seed extract, 0.3~0.5 part of mung bean seed extract, nutmeg benevolence extract 1.8~ 2.2 parts, 1.8~2.2 parts of cardiospermum halicacabum flower/leaf/boisiana extract, Mosla chinensis/0.3~0.6 part of leaf/stem extraction, the fruit of summer cypress mentions Taking 0.3~0.5 part of object, ampelopsis grossdentata leaf extracts 0.2~0.5 part, and 0.2~0.4 part of peony extract, safflower flower extract 1.2~1.8 parts, 0.3~0.6 part of fructus arctii seed extract, 0.2~0.5 part of Schisandra fruit extract, Flos Mume extract 0.2~0.4 Part.
- The ointment of multiple reparation 5. a kind of antiallergic is releived, which is characterized in that including following components, 6~15 parts of saualane, beeswax 5 It is~9 parts, 25~35 parts of atoleine, 7-12 parts of microwax, 1~2 part of paraffin, 1~3 part of polyethylene, 0.1~2 part of tocopherol, red 0.1~1 part of bisabol, 0.5~1.5 part of octyl dodecanol, 0.1~3 part of hexyl decyl alcohol, N~palmityl hydroxy-proline spermaceti 0.1~1 part of ester, 0.1~0.5 part of stearic acid, 0.1~0.5 part of campesterol class, 1~3 part of caprylic/capric triglyceride, fourth hydroxyl 0.1 part of toluene, 0.1~1 part of lecithin, 0.1~2 part of natural tocopherol, 0.1~1 part of red myrrh alcohol and claim 1 or Person's claim 2 or claim 3 or antiallergic as claimed in claim 4 are releived multiple remediation composition.
- The method of the ointment of multiple reparation 6. antiallergic described in preparation claim 5 is releived, which is characterized in that successively include following Step:1) jojoba oil, saualane, beeswax, atoleine, microwax are weighed by mass number described in claims 5, paraffin, Polyethylene is added in beaker, is put into 80~85 DEG C of thermostat water bath and is heated, stand-by as solution a；2) it weighs remaining component to be added in beaker, beaker is put into 55~60 DEG C of water-baths, it is stand-by as solution b；3) when the temperature of solution a, solution b reach 55~60 DEG C simultaneously, the drainage of solution b glass bar is slowly added into solution a In, it is stirring while adding, ointment is repaired until forming uniform ointment and releiving to get antiallergic.
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| CN114028277A (en) * | 2021-12-22 | 2022-02-11 | 广州阳菲生物科技有限公司 | Skin-soothing cream with effects of relieving and repairing sensitive skin |
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| CN112353931A (en) * | 2020-11-25 | 2021-02-12 | 广州旭升化工科技有限公司 | Chinese herbal medicine compound ointment for soothing skin of infants and preparation method thereof |
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