CN110205228A - A kind of fructus cannabis coffee alcoholic drink mixed with fruit juice formula and preparation method thereof for alleviating gout - Google Patents
A kind of fructus cannabis coffee alcoholic drink mixed with fruit juice formula and preparation method thereof for alleviating gout Download PDFInfo
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Abstract
The invention discloses a kind of for alleviating the fructus cannabis coffee alcoholic drink mixed with fruit juice formula of gout, is mainly prepared by fructus cannabis alcoholic drink mixed with fruit juice, coffee alcoholic drink mixed with fruit juice, tea wine, haematococcus pluvialis, grape pip, lily, parsley, cape jasmine, semen coicis and lemon alcoholic drink mixed with fruit juice；The formula of the coffee alcoholic drink mixed with fruit juice mainly includes coffee bean, cheese, bajiao banana, sugarcane, granulated sugar, lemon, edible alcohol；Using coffee bean as primary raw material, is baked using the stage, the method for wine immersion is directly added to be made；The fructus cannabis alcoholic drink mixed with fruit juice is mainly prepared by fructus cannabis, betadex, edible alcohol；The tea wine is mainly prepared by tealeaves, rose, lemon, hazelnut kernel, cape jasmine, edible alcohol.This fiery coffee wind alcoholic drink mixed with fruit juice has gout certain therapeutic effect.
Description
Technical field
It is specifically a kind of for alleviating the fructus cannabis coffee alcoholic drink mixed with fruit juice formula of gout the present invention relates to alcoholic drink mixed with fruit juice production technical field
And preparation method thereof.
Background technique
Alcoholic drink mixed with fruit juice is using Spirit, fermented wine or edible alcohol as wine base, with the animals and plants essence of dual-purpose of drug and food, by advanced work
Skill is process, and changes the alcoholic drink of its former wine base style.
Alcoholic drink mixed with fruit juice has the characteristics that full of nutrition, various in style, different style, including flowers and fruits type alcoholic drink mixed with fruit juice, animals and plants aroma type,
The wine product such as tonic nutrient liquor.
Display in " 2017 Chinese gout status report white paper ", China's Patients with Hyperuricemia number up to 1.7 hundred million,
Wherein patient with gout is more than 80,000,000 people, and is just increased sharply with annual 9.7% annual growth.It is expected that the year two thousand twenty, gout
Number is up to 100,000,000.Gout has become the second largest metabolism class disease that China is only second to diabetes now, is very important
Health warning.
The pain of gout, in great pain, pain are felt embarrassed to mention.The label of gout is uric acid height, and Monosodium urate crystallization is diagnosis gout
Standard.Studies have shown that reducing the generation of purine in human body, the intracorporal endogenous uric acid of people just can be reduced.
Summary of the invention
The present invention provides a kind of fructus cannabis coffee alcoholic drink mixed with fruit juice formula and preparation method thereof for alleviating gout, has for gout
Certain therapeutic effect.
The present invention protect it is a kind of for alleviating the fructus cannabis coffee alcoholic drink mixed with fruit juice formula of gout, mainly by fructus cannabis alcoholic drink mixed with fruit juice, coffee
Alcoholic drink mixed with fruit juice, tea wine, haematococcus pluvialis, grape pip, lily, parsley, cape jasmine, semen coicis and lemon alcoholic drink mixed with fruit juice are prepared.
Further, the formula of the coffee alcoholic drink mixed with fruit juice mainly includes coffee bean, cheese, bajiao banana, sugarcane, granulated sugar, lemon, food
Use alcohol；Using coffee bean as primary raw material, is baked using the stage, the method for wine immersion is directly added to be made.
Further, the fructus cannabis alcoholic drink mixed with fruit juice is mainly prepared by fructus cannabis, betadex, edible alcohol.
Further, the tea wine is mainly prepared by tealeaves, rose, lemon, hazelnut kernel, cape jasmine, edible alcohol.
The present invention also protects a kind of for alleviating the preparation method of the fructus cannabis coffee alcoholic drink mixed with fruit juice of gout, which is characterized in that packet
Include following steps:
Step 1: lily, parsley, cape jasmine, semen coicis being worn into fine powder by the mass ratio of 3:1:1:1, is packed into cotton bag, must match
Expect A；
Step 2: 95% alcohol reflux of haematococcus pluvialis triplication being extracted three times, extracting solution recycling ethyl alcohol is simultaneously concentrated into original
Crude drug amount obtains ingredient B；
Step 3: 95% alcohol reflux of grape pip triplication being extracted three times, extracting solution recycling ethyl alcohol is simultaneously concentrated into crude drug in whole
Amount, obtains ingredient C；
Step 4: fructus cannabis alcoholic drink mixed with fruit juice, coffee alcoholic drink mixed with fruit juice, tea wine being mixed according to the mass ratio of 2:2:1, wine liquid D must be mixed；
Step 5: ingredient A, B, C being dipped in mixing wine liquid D according to the ratio of 1:2:2, wine liquid E must be mixed, and at 50-60 DEG C
Under the conditions of, water bath sonicator 30min；The ratio for mixing wine liquid D and ingredient A, B, C is 9:1:2:2；
Step 6: by lemon alcoholic drink mixed with fruit juice with mix wine liquid E according to 1:1 mass ratio mix, at a temperature of 18-26 DEG C stand 28d with
On；
Step 7: pressing alcoholic drink mixed with fruit juice standard GB/T/T27588--2011, adjusted alcohol total reducing sugar to conjunction with pure water or height ethyl alcohol
After lattice, filters, is filling.
Further, the preparation method of the coffee alcoholic drink mixed with fruit juice carries out primary baking the following steps are included: 1. choosing coffee bean,
Coffee bean is baked to light yellow；2. the sugarcane of the cheese of coffee bean amount 5-10%, the bajiao banana of 1-3%, 1-5% is added, stirring is baked extremely
Coffee bean is in brown color；Be added in the edible alcohol of 4-60%vol 3. taking out, sealed in the environment of 15-30 DEG C cellar for storing things 28 days with
On；4. before filling, the granulated sugar of 0-300g/L, the lemon juice of 3-10g/L being added, stirs evenly, filter.
Further, the preparation method of the fructus cannabis alcoholic drink mixed with fruit juice includes the following steps the preparation method of the fructus cannabis alcoholic drink mixed with fruit juice
The following steps are included: 1. screening, that is, select full grains, the fructus cannabis without moldy metamorphism, free from insect pests；2. toasting, after screening
Fructus cannabis raw material grind to 5 mesh more than, be laid on drip pan, be put into oven braking, 160 DEG C of baking temperature, duration
30min is dried to moisture lower than 8%；3. impregnating extraction, immersion extraction first is carried out to fructus cannabis powder with edible alcohol, after filtering
After the filter residue drying arrived, then with petroleum ether immersion extraction is carried out, specifically includes the following steps: fructus cannabis powder is pressed with edible alcohol
Solution A is mixed into according to the mass ratio of 1:5 ', it stirs at room temperature, impregnate and filter afterwards for 24 hours, obtain filtrate A ', filter residue A '；By filter residue A ' with
Edible alcohol is mixed into solution B according to the mass ratio of 1:3 ', at room temperature stir, impregnate filter afterwards for 24 hours, obtain liquor B ', filter residue B ';
Filter residue B ' is put into oven baking, its moisture content is dried to 3-5%；According to the mass ratio of 1:1, it is added into the filter residue B ' of drying
Petroleum ether obtains solution C ', solution C ' water bath sonicator 30min, at room temperature stir, impregnate 2h, filtering, obtain liquor C ', filter residue C '；
Solution D is obtained to petroleum ether is added in filter residue C ' according to the mass ratio of 1:1 ', solution D ' water bath sonicator 30min, stir at room temperature,
2h is impregnated, filtering obtains filtrate D ', filter residue D ', and stirring, soaking temperature are no more than 50 DEG C；By liquor C ', filtrate D ' steaming petroleum ether
Paste afterwards is added edible alcohol by the mass ratio of 1:5, filters after the 2h that flows back, obtain filtrate E ', filter residue E ';Filter residue E ' presses 1:5
Mass ratio be added edible alcohol, flow back 2h after filter, obtain filtrate F ', filter residue F ';4. by filtrate A ', liquor B ', filtrate E ', filter
It is filtered after liquid F ' mixing, obtains filtrate P '；5. food grade betadex is weighed according to the 8% of fructus cannabis material quality ratio, according to 1:
Pure water is added in 5 mass ratio, stirs at 50 °C, after betadex is completely dissolved, is slowly added to filtrate P ',
Continue after stirring 30min, stop heating, continues after stirring 8h, filter to get filtrate Q '；6. working as in right amount to being added in the filtrate Q '
Return extract, capejasmine extract, lemon extract and granulated sugar, angelica extract, capejasmine extract, lemon extract and granulated sugar
Additive amount is adjusted according to taste；7. adjusting the alcoholic strength of alcoholic drink mixed with fruit juice by addition pure water or edible alcohol.
Further, 1. the preparation method of the tea wine is the following steps are included: select qualified finished tea, according to 1:3's
The edible alcohol of 75%vol is added in mass ratio, filters after impregnating 15min at room temperature, obtains filtrate A, filter residue A；2. according to the matter of 1:2
Ratio is measured, 80-85 DEG C of hot water is added into filter residue A, constant temperature filters after impregnating 15min, obtains liquor B, filter residue B；3. weighing rose respectively
Rare flower, lemon juice, hazelnut kernel, cape jasmine, and the edible alcohol of 75%vol is added into each material, the additive amount of edible alcohol is rose
Twice of the respective quality of flower, lemon juice, hazelnut kernel, cape jasmine, stir at room temperature, impregnate 72h after filter, obtain liquor C, filter residue C；④
Mixed filtrate A, liquor B, liquor C according to a certain percentage obtain filtrate P；5. adding pure water or edible alcohol adjustment into filtrate P
The alcoholic strength of alcoholic drink mixed with fruit juice.
Beneficial effects of the present invention: plant polyphenol and antioxidant content are rich in；Plant polyphenol easily with the protein in food
Generate combination with purine, and excreted in the form of this combination, thus reduce or reduce human body to protein in food and
The taken in excess and utilization of purine, in addition the vicinal hydroxyl groups of plant polyphenol can generate chelatropic reaction with sodium, to just reduce body
The content of interior excessive free sodium ion, thus have the function that be reduced or avoided excessive sodium in conjunction with high lithemia, it is intracorporal
Monosodium urate crystallization lacked occur without, gout or a possibility that recurrence just reduce or without；Antioxidant content enhancing
Cell viability is able to maintain the normal statement period, reduces cell because of excessive oxidation, early ageing premature death and releases nucleic acid material,
The generation for reducing endogenous purine, to reduce endogenous uric acid amount；Fiery coffee wind alcoholic drink mixed with fruit juice is similar to liquid medicine, eats side
Just, 25-50mL is taken daily, is taken convenient for medium-term and long-term, no drinking person, and water-bath boils off wine degree before can taking.
Specific embodiment
The present invention will be further described in detail with reference to the specific embodiments.The embodiment of the present invention is to show
It is provided for the sake of example and description, and is not exhaustively or to limit the invention to disclosed form.Many modifications and
Variation is obvious for the ordinary skill in the art.Selection and description embodiment are to more preferably illustrate this
The principle and practical application of invention, and make those skilled in the art it will be appreciated that the present invention is to which design is suitable for specific
The various embodiments with various modifications of purposes.
Embodiment 1
It is a kind of for alleviating the fructus cannabis coffee alcoholic drink mixed with fruit juice formula of gout, it is mainly raw by fructus cannabis alcoholic drink mixed with fruit juice, coffee alcoholic drink mixed with fruit juice, tea wine, rain
Haematococcus, grape pip, lily, parsley, cape jasmine, semen coicis and lemon alcoholic drink mixed with fruit juice are prepared.
The formula of the coffee alcoholic drink mixed with fruit juice mainly includes coffee bean, cheese, bajiao banana, sugarcane, granulated sugar, lemon, edible alcohol；With
Coffee bean is primary raw material, is baked using the stage, the method for wine immersion is directly added to be made；The fructus cannabis alcoholic drink mixed with fruit juice is mainly by fiery fiber crops
Benevolence, betadex, edible alcohol are prepared；The tea wine is mainly by tealeaves, rose, lemon, hazelnut kernel, cape jasmine, food
It is prepared with alcohol.
It is described fire coffee wind alcoholic drink mixed with fruit juice preparation method the following steps are included:
Step 1: lily, parsley, cape jasmine, semen coicis being worn into fine powder by the mass ratio of 3:1:1:1, is packed into cotton bag, must match
Expect A；
Step 2: 95% alcohol reflux of haematococcus pluvialis triplication being extracted three times, extracting solution recycling ethyl alcohol is simultaneously concentrated into original
Crude drug amount obtains ingredient B；
Step 3: 95% alcohol reflux of grape pip triplication being extracted three times, extracting solution recycling ethyl alcohol is simultaneously concentrated into crude drug in whole
Amount, obtains ingredient C；
Step 4: fructus cannabis alcoholic drink mixed with fruit juice, coffee alcoholic drink mixed with fruit juice, tea wine being mixed according to the mass ratio of 2:2:1, wine liquid D must be mixed；
Step 5: ingredient A, B, C being dipped in mixing wine liquid D according to the ratio of 1:2:2, wine liquid E must be mixed, and at 50-60 DEG C
Under the conditions of, water bath sonicator 30min；The ratio for mixing wine liquid D and ingredient A, B, C is 9:1:2:2；
Step 6: by lemon alcoholic drink mixed with fruit juice with mix wine liquid E according to 1:1 mass ratio mix, at a temperature of 18-26 DEG C stand 28d with
On；
Step 7: pressing alcoholic drink mixed with fruit juice standard GB/T/T27588--2011, adjusted alcohol total reducing sugar to conjunction with pure water or height ethyl alcohol
After lattice, filters, is filling.
Gout breaking-out or recurrence are mainly crystallized in the Monosodium urate of joint, are formed gout and are needed high lithemia and had in vivo
The sodium of amount, when both substances are combined into Monosodium urate crystallization, gout can just occur, and then prevent and treat gout, and one will be reduced in vivo
Uric acid;Two will exclude internal excessive sodium.
It is rich in coffee polyphenols in coffee alcoholic drink mixed with fruit juice, tea polyphenols are rich in tea wine, cannabinoids are rich in fructus cannabis alcoholic drink mixed with fruit juice, rain is raw
Haematococcus contains astaxanthin, contains anthocyanidin in grape pip.Scientific experiment proves, plant polyphenol, astaxanthin, anthocyanidin, parsley
With stronger antioxidation, the oxidation of these ingredient anti-cells enhances cell viability, is able to maintain the normal statement period, subtracts
Few cell releases nucleic acid material because of excessive oxidation, early ageing premature death, that is, the generation of endogenous purine is reduced, to reduce
Endogenous uric acid amount.
Plant polyphenol is the general name of Polyhydroxy phenol, has been applied to the multiple fields such as medical treatment, food.Plant is more
Phenol easily in food protein and purine generation is combined, and excreted in the form of this combination, to reduce or reduction
Human body is to the taken in excess and utilization of protein in food and purine, therefore drinking the fiery coffee wind alcoholic drink mixed with fruit juice rich in plant polyphenol can
Greatly reduce the purine source in food, often drink the acquisition that can reduce exogenous purine, to reduce exogenous uric acid
It generates.
In addition, the vicinal hydroxyl groups of plant polyphenol can generate chelatropic reaction with sodium, to just reduce excessive free in vivo
The content of sodium ion, to have the function that be reduced or avoided excessive sodium in conjunction with high lithemia, intracorporal Monosodium urate crystallization is few
Occur without, gout or a possibility that recurrence just reduce or without.
The effect of a kind of effect of raw material is not equal to its each raw material it is simple cumulative, there are phases after each material combination combination
The relationship of a variety of interactions such as life, mutual reinforcement between, mutual restraint between two drugs or the mutual-detoxication；The increase and decrease of each raw material component, the number of dosage can all make the group
Complicated variation occurs for the function for closing object；These variations include the enhancing of original effect or the disappearance of decrease or original effect,
Even generating opposite side effect.Fire coffee wind alcoholic drink mixed with fruit juice of the invention is using traditional, classics organic to the extraction of plant polyphenol
Solvent alcohol is combined with using modern ultrasound extractive technique, greatly improves the extraction efficiency and purity of polyphenol components.
Cape jasmine: heat-clearing, purging intense heat, cool blood cure mainly bloody flux, hematuria, pathopyretic ulcer and strain swelling and pain etc., and ancient times discuss invention Cape jasmine
Son contains Gardenoside and crocin, there is helping to change for low uric acid.
Semen coicis: treatment gout can inhibit the synthesis of uric acid, so as to cause the effect for reducing uric acid, moreover it is possible to promote
More uric acid are discharged, structural urate crystal in mild analysis blood back liquid, then is excreted by urine, effectively
Purification blood, reduce blood uric acid.
Lily: effective analgesic component " colchiceine " when containing gout acute attack, because in fiery coffee wind wine
Colchiceine in conjunction with milk constituents, with plant polyphenol chelating and reduce or the side effect that disappeared.
The preparation method of the coffee alcoholic drink mixed with fruit juice carries out primary baking the following steps are included: 1. choosing coffee bean, and coffee bean dries
It roasts to light yellow；2. the sugarcane of the cheese of coffee bean amount 5-10%, the bajiao banana of 1-3%, 1-5% is added, stirring, which is baked to coffee bean, is in
Brown color；It is added in the edible alcohol of 4-60%vol 3. taking out, is sealed cellar for storing things 28 days or more in the environment of 15-30 DEG C；4. filling
Before dress, the granulated sugar of 0-300g/L, the lemon juice of 3-10g/L is added, stirs evenly, filter.
The cold soaking technique for directly adding wine to impregnate using ripe coffee bean, remain coffee from savory and wine mellowness, lemon
The mouthfeel of the adjustable coffee of lemon；There is no fermentation process in technique, greatly reduce total number of bacteria in product, improves and drink food
The safety of product；The coffee alcoholic drink mixed with fruit juice prepared meets national alcoholic drink mixed with fruit juice standard GB/T27588-2011, rich in alkaline coffee polyphenols.
The preparation method of the fructus cannabis alcoholic drink mixed with fruit juice includes the following steps that the preparation method of the fructus cannabis alcoholic drink mixed with fruit juice includes following
Step: 1. screening, that is, selects full grains, the fructus cannabis without moldy metamorphism, free from insect pests；2. toasting, by the fructus cannabis after screening
It more than raw material grind to 5 mesh, is laid on drip pan, is put into oven braking, 160 DEG C of baking temperature, duration 30min is dried to
Moisture is lower than 8%；3. impregnating extraction, immersion extraction first is carried out to fructus cannabis powder with edible alcohol, the filter residue drying obtained after filtering
Afterwards, then with petroleum ether immersion extraction is carried out, specifically includes the following steps: by fructus cannabis powder and edible alcohol according to the quality of 1:5
Than being mixed into solution A ', it stirs at room temperature, impregnate and filter afterwards for 24 hours, obtain filtrate A ', filter residue A '；Filter residue A ' is pressed with edible alcohol
Be mixed into solution B according to the mass ratio of 1:3 ', at room temperature stir, impregnate filter afterwards for 24 hours, obtain liquor B ', filter residue B ';Filter residue B ' is put
Enter oven baking, its moisture content is dried to 3-5%；According to the mass ratio of 1:1, petroleum ether is added into the filter residue B ' of drying, obtains molten
Liquid C ', solution C ' water bath sonicator 30min, at room temperature stir, impregnate 2h, filtering, obtain liquor C ', filter residue C '；According to the matter of 1:1
Ratio is measured, to petroleum ether is added in filter residue C ', obtains solution D ', solution D ' water bath sonicator 30min is stirred at room temperature, is impregnated 2h, mistake
Filter, obtains filtrate D ', filter residue D ', and stirring, soaking temperature are no more than 50 DEG C；By liquor C ', the paste after filtrate D ' steaming petroleum ether
Object is added edible alcohol by the mass ratio of 1:5, filters after the 2h that flows back, obtain filtrate E ', filter residue E ';Filter residue E ' presses the mass ratio of 1:5
Edible alcohol is added, is filtered after the 2h that flows back, obtains filtrate F ', filter residue F ';4. by filtrate A ', liquor B ', filtrate E ', filtrate F ' mixing
After filter, obtain filtrate P '；5. food grade betadex is weighed according to the 8% of fructus cannabis material quality ratio, according to the quality of 1:5
Than pure water is added, stirs at 50 °C, after betadex is completely dissolved, be slowly added to filtrate P ', continue to stir
After 30min, stop heating, continues after stirring 8h, filter to get filtrate Q '；6. being extracted to appropriate Radix Angelicae Sinensis is added in the filtrate Q '
Object, capejasmine extract, lemon extract and granulated sugar, angelica extract, capejasmine extract, lemon extract and granulated sugar additive amount
It is adjusted according to taste；7. adjusting the alcoholic strength of alcoholic drink mixed with fruit juice by addition pure water or edible alcohol.
The edible alcohol referred in the preparation method of fructus cannabis alcoholic drink mixed with fruit juice is 95%vol or more, because of some in fructus cannabis
Ingredient indissoluble is not soluble in water, but is dissolved in organic solvent alcohol, and alcoholic strength is higher, and ingredient therein is just easy to leach.This hair
It is bright that immersion extraction first is carried out to fructus cannabis powder with edible alcohol, that is, ethyl alcohol, after the filter residue drying obtained after filtering, then use petroleum ether
Immersion extraction is carried out, first inorganic compound, small-molecule substance are extracted with ethyl alcohol, then with having in petroleum ether extraction raw material
Machine compound, so that the inorganic compound and organic compound in raw material are fully extracted out；Recycle betadex
It is wrapped, extract ingredient is wrapped up, adjustable mouthfeel increases solubility, especially increase bioavilability, simultaneously
Keep fructus cannabis alcoholic drink mixed with fruit juice color bright orange.
The main component of fructus cannabis is wrapped in its histocyte, and cell periphery is one layer of cellulose, hemicellulose and fruit
The cell wall of the material compositions such as glue is plasm in cell wall.The step 3. in solution A, solution B, solution C stirring,
Water bath sonicator 30min, can destroy plasmic physiological function, so that the effective component in fructus cannabis histocyte before impregnating
And other solable matters penetrate into outside cell, improve recovery rate.
The step 3. in 130-160 DEG C of baking temperature of filter residue B, duration 15-35min is mainly used for fructus cannabis
Moisture content in powder is baked between 3-5%, reduces the water content in filter residue B, improves fructus cannabis internal component in petroleum ether
Recovery rate, and promote cannabidiol this ingredient maturation in fructus cannabis, making it, there is no bioactivity, to will not convert
For toxic four phenol of hemp.
The preparation method of the tea wine according to the mass ratio of 1:3, adds the following steps are included: 1. select qualified finished tea
Enter the edible alcohol of 75%vol, is filtered after impregnating 15min at room temperature, obtain filtrate A, filter residue A；2. according to the mass ratio of 1:2, to filter
80-85 DEG C of hot water is added in slag A, constant temperature filters after impregnating 15min, obtains liquor B, filter residue B；3. weighing rose, lemon respectively
Juice, hazelnut kernel, cape jasmine, and the edible alcohol of 75%vol is added into each material, the additive amount of edible alcohol is rose, lemon
Twice of the respective quality of juice, hazelnut kernel, cape jasmine, stir at room temperature, impregnate 72h after filter, obtain liquor C, filter residue C；4. according to one
Certainty ratio mixed filtrate A, liquor B, liquor C, obtain filtrate P；5. adding pure water into filtrate P or edible alcohol adjusting alcoholic drink mixed with fruit juice
Alcoholic strength.
Tealeaves is impregnated with the edible alcohol of 75%vol, it is sufficient to be killed the zymophyte retained in tealeaves and various miscellaneous bacterias, be made tea
Wine can be trusted and be drunk；Water bath sonicator can destroy plasmic physiological function, so that tealeaves, rose, lemon juice, fibert
Benevolence, cape jasmine histocyte in effective component (including tea polyphenols) and other solable matters penetrate into outside cell wall, it is molten
Solution improves recovery rate in alcohol；Single tea smell is deployed into plant by the addition of rose, lemon, hazelnut kernel, cape jasmine
The natural compound perfume (or spice) of body, making tea wine not only has tea perfume, aroma, also the compound perfume (or spice) containing various plant, and all fragrant harmonious, aftertaste is long
Far.
The formula and preparation method thereof of coffee alcoholic drink mixed with fruit juice is disclosed in the application for a patent for invention that applicant applies early period
In 201811099503.3；The formula and preparation method thereof of fructus cannabis alcoholic drink mixed with fruit juice is disclosed in the patent of invention Shen that applicant applies early period
It please be in 201811473030.9；Formula of tea wine and preparation method thereof is disclosed in the application for a patent for invention that applicant applies early period
In 201811472164.9.
It is disclosed by the invention to be used to alleviate fructus cannabis coffee alcoholic drink mixed with fruit juice formula of gout and preparation method thereof clinical application proves that right
Gout has certain therapeutic effect.
Application Example 1
Mr. Lin, male, 68 years old, case history 11 years, 603 mM/liter of uric acid before treating, Symptoms were frequent, joint deformity, foot thumb
Fester flow liquid on the inside of articulations digitorum manus, and 6 centimeters of mass maximum gauge, year bed is 3/4ths.After taking fiery coffee wind wine 12 days, urine
(white) is discharged in acid crystal；There is within 18 days arthralgia transfer, crystallization excretion increases, and mass starts to soften, and scope of activities starts to change
Kind, complexion is taken on a new look；It takes 30 days (course for the treatment of), arthralgia fades away, and crystallization discharge rate continues to increase, uric acid level 508
∕ liters of milli Mo Er；It is nimble without pain, but not to take 60 days joints, occurs the short-term inflammation of simple joint, 440 mmoles of uric acid level sometimes
∕ liters of Er；It takes and continues within 90 days the big radian improvement of excretion crystallization constitution, participation is suitably taken exercise and social activities, 410 milli of uric acid level
∕ liters of Mo Er；Medication still has a small amount of crystallization discharge for 180 days, and uric acid level wave is continued to decline to ∕ liters of 380 milli Mo Er, ulceration
Mouth starts drying, and has new flesh growth gradually to heal；It takes 240 days, uric acid crystal gradually drains, and mass is gradually reduced, joint
Scope of activities increase can participate in normal person's activity, and after deactivating 1 year, no recurrence, uric acid keeps normal, not avoid eating strictly, mass base
Originally it is absorbed.
Application Example 2
Poplar, male, 60 years old, be first multi-joint red and swollen heat pain by developing after brothers' articulations digitorum manus pain, 508 milli Mo Er ∕ of uric acid level is public
It rises, takes the alleviation of aching in 14 hours or so after drinking of fiery coffee wind, posterior joint swelling and pain in 72 hours disappear；Continue symptom after taking 10
Gradually mitigate；It takes symptom on the 20th to fade away, uric acid is ∕ liters of 450 milli Mo Er；To consolidate curative effect, patient continuously takes two
A course for the treatment of (60 days), uric acid level are down to ∕ liters of 318 milli Mo Er；Later six months follow-up is deactivated, uric acid level keeps normal, no recurrence.
Application Example 3
Poplar, male, 55 years old, patient's left foot toe, instep repeatability swell and ache 6 years, patient 6 years before after drinking once, occur suddenly
Left foot back, thumb swelling and pain, it is difficult to fall asleep, the scorching hot redness in part, after anti-inflammatory analgesic is taken in locality, pain is slow after a week
Solution, it is from then on, i.e. easy after drinking or catch a cold to break out, on breaking-out, the medicines such as prednisone are taken certainly, and drug effect is not after long-term use
Good, pain is fixed on left foot back and left thumb.Last year suffers from cold due to disease hair because being lying when sleeping after drinking again, local red and swollen heat pain, function limitation,
Fiery coffee wind wine is taken in trial, drinks 30 days, gout remains dormant；After 60 days, symptom disappears, and walks freely, no limping；To consolidate
It is continued taking the two courses Gu curative effect is advised.It follow-up 1 year, does not recur.
Application Example 4
Knife xx, male, 85 years old, the right foot swelling and pain of old man cannot walk 4 days, toenail be cut before 4 days, then right foot starts to swell and ache, and identifies oneself
" inflammation ", is not treated, cannot be walked after swelling and pain aggravation, diet is poor, and urine is less, and dry and hard excrement, a few days does not solve, senile dementia
For many years, while left foot hallux toe equally has slight redness, and tenderness, is for gout symptom.Take fiery coffee wind wine twice a day, once
50ml, swell and ache obvious recession after continuously taking three days, and can leave the bed walking, and loose stools improves as usual twice, after 6 days.
Obviously, described embodiment is only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, this field and those of ordinary skill in the related art institute without creative labor
The every other embodiment obtained, all should belong to the scope of protection of the invention.
Claims (9)
1. a kind of for alleviating the fructus cannabis coffee alcoholic drink mixed with fruit juice formula of gout, which is characterized in that mainly revealed by fructus cannabis alcoholic drink mixed with fruit juice, coffee
Wine, tea wine, haematococcus pluvialis, grape pip, lily, parsley, cape jasmine, semen coicis and lemon alcoholic drink mixed with fruit juice are prepared.
2. according to claim 1 for alleviating the fructus cannabis coffee alcoholic drink mixed with fruit juice formula of gout, which is characterized in that the coffee
The formula of alcoholic drink mixed with fruit juice mainly includes coffee bean, cheese, bajiao banana, sugarcane, granulated sugar, lemon, edible alcohol；It is main former with coffee bean
Material is baked using the stage, the method for wine immersion is directly added to be made.
3. according to claim 1 for alleviating the fructus cannabis coffee alcoholic drink mixed with fruit juice formula of gout, which is characterized in that the fire fiber crops
Benevolence alcoholic drink mixed with fruit juice is mainly prepared by fructus cannabis, betadex, edible alcohol.
4. according to claim 1 for alleviating the fructus cannabis coffee alcoholic drink mixed with fruit juice formula of gout, which is characterized in that the tea wine
Mainly it is prepared by tealeaves, rose, lemon, hazelnut kernel, cape jasmine, edible alcohol.
5. a kind of for alleviating the preparation method of the fructus cannabis coffee alcoholic drink mixed with fruit juice of gout, which comprises the following steps:
Step 1: lily, parsley, cape jasmine, semen coicis being worn into fine powder by the mass ratio of 3:1:1:1, is packed into cotton bag, must match
Expect A；
Step 2: 95% alcohol reflux of haematococcus pluvialis triplication being extracted three times, extracting solution recycling ethyl alcohol is simultaneously concentrated into original
Crude drug amount obtains ingredient B；
Step 3: 95% alcohol reflux of grape pip triplication being extracted three times, extracting solution recycling ethyl alcohol is simultaneously concentrated into crude drug in whole
Amount, obtains ingredient C；
Step 4: fructus cannabis alcoholic drink mixed with fruit juice, coffee alcoholic drink mixed with fruit juice, tea wine being mixed according to the mass ratio of 2:2:1, wine liquid D must be mixed；
Step 5: ingredient A, B, C are dipped in mixing wine liquid D according to the ratio of 1:2:2, must mixs wine liquid E, mix wine liquid D and
The ratio of ingredient A, B, C are 9:1:2:2；
Step 6: by lemon alcoholic drink mixed with fruit juice with mix wine liquid E according to 1:1 mass ratio mix, at a temperature of 18-26 DEG C stand 28d with
On；
Step 7: pressing alcoholic drink mixed with fruit juice standard GB/T/T27588--2011, adjusted alcohol total reducing sugar to conjunction with pure water or height ethyl alcohol
After lattice, filters, is filling.
6. according to claim 5 for alleviating the preparation method of the fructus cannabis coffee alcoholic drink mixed with fruit juice of gout, which is characterized in that
Step 6 by lemon alcoholic drink mixed with fruit juice with mix wine liquid E mix before, under the conditions of 50-60 DEG C, water bath sonicator 30min.
7. according to claim 5 for alleviating the preparation method of the fructus cannabis coffee alcoholic drink mixed with fruit juice of gout, which is characterized in that institute
The preparation method of coffee alcoholic drink mixed with fruit juice is stated the following steps are included: 1. choosing coffee bean carries out primary baking, coffee bean is baked to light yellow；
2. the sugarcane of the cheese of coffee bean amount 5-10%, the bajiao banana of 1-3%, 1-5% is added, it is in brown color that stirring, which is baked to coffee bean,；3. taking
It is added in the edible alcohol of 4-60%vol, is sealed cellar for storing things 28 days or more in the environment of 15-30 DEG C out；4. before filling, 0- is added
The lemon juice of the granulated sugar of 300g/L, 3-10g/L, stirs evenly, filters.
8. according to claim 5 for alleviating the preparation method of the fructus cannabis coffee alcoholic drink mixed with fruit juice of gout, which is characterized in that institute
The preparation method for stating fructus cannabis alcoholic drink mixed with fruit juice includes the following steps the preparation method of the fructus cannabis alcoholic drink mixed with fruit juice the following steps are included: 1. sieving
Choosing, that is, select full grains, the fructus cannabis without moldy metamorphism, free from insect pests；2. toasting, extremely by the fructus cannabis raw material grind after screening
It more than 5 mesh, is laid on drip pan, is put into oven braking, 160 DEG C of baking temperature, duration 30min, is dried to moisture lower than 8%；
3. impregnating extraction, immersion extraction first is carried out to fructus cannabis powder with edible alcohol, after the filter residue drying obtained after filtering, then uses petroleum
Ether carries out immersion extraction, specifically includes the following steps: fructus cannabis powder and edible alcohol are mixed into solution according to the mass ratio of 1:5
A ' stirs at room temperature, impregnates and filter afterwards for 24 hours, obtains filtrate A ', filter residue A '；By filter residue A ' and edible alcohol according to the mass ratio of 1:3
Be mixed into solution B ', at room temperature stir, impregnate filter afterwards for 24 hours, obtain liquor B ', filter residue B ';Filter residue B ' is put into oven baking, it will
Its moisture content is dried to 3-5%；According to the mass ratio of 1:1, petroleum ether is added into the filter residue B ' of drying, obtains solution C ', solution C '
Water bath sonicator 30min, at room temperature stir, impregnate 2h, filtering, obtain liquor C ', filter residue C '；According to the mass ratio of 1:1, to filter residue C '
Middle addition petroleum ether, obtains solution D ', solution D ' water bath sonicator 30min is stirred at room temperature, is impregnated 2h, and filtering obtains filtrate D ', filter
Slag D ', stirring, soaking temperature are no more than 50 DEG C；By liquor C ', the paste after filtrate D ' steaming petroleum ether, by the quality of 1:5
Than edible alcohol is added, is filtered after the 2h that flows back, obtain filtrate E ', filter residue E ';Edible alcohol is added by the mass ratio of 1:5 in filter residue E ',
It is filtered after reflux 2h, obtains filtrate F ', filter residue F ';4. by filtrate A ', liquor B ', filtrate E ', filtrate F ' mixing after filter, obtain filtrate
P'；5. weighing food grade betadex according to the 8% of fructus cannabis material quality ratio, pure water is added according to the mass ratio of 1:5,
It stirs at 50 °C, after betadex is completely dissolved, is slowly added to filtrate P ', continue after stirring 30min, stop adding
Temperature continues after stirring 8h, and filter to get filtrate Q '；6. to appropriate angelica extract, capejasmine extract, lemon are added in the filtrate Q '
Lemon extract and granulated sugar, angelica extract, capejasmine extract, lemon extract and granulated sugar additive amount adjusted according to taste；⑦
The alcoholic strength of alcoholic drink mixed with fruit juice is adjusted by addition pure water or edible alcohol.
9. according to claim 5 for alleviating the preparation method of the fructus cannabis coffee alcoholic drink mixed with fruit juice of gout, which is characterized in that institute
The preparation method of tea wine is stated the following steps are included: 1. selecting qualified finished tea, according to the mass ratio of 1:3, is added 75%vol's
Edible alcohol filters after impregnating 15min at room temperature, obtains filtrate A, filter residue A；2. being added according to the mass ratio of 1:2 into filter residue A
80-85 DEG C of hot water, constant temperature filter after impregnating 15min, obtain liquor B, filter residue B；3. weigh respectively rose, lemon juice, hazelnut kernel,
Cape jasmine, and the edible alcohol of 75%vol is added into each material, the additive amount of edible alcohol is rose, lemon juice, hazelnut kernel, Cape jasmine
Twice of sub respectively quality stirs at room temperature, filters after immersion 72h, obtain liquor C, filter residue C；4. mixing filter according to a certain percentage
Liquid A, liquor B, liquor C obtain filtrate P；5. adding the alcoholic strength of pure water or edible alcohol adjustment alcoholic drink mixed with fruit juice into filtrate P.
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