CN110200845A

CN110200845A - It is a kind of for the skin care item for repairing sensitive skin of releiving

Info

Publication number: CN110200845A
Application number: CN201910602114.6A
Authority: CN
Inventors: 莫美玲
Original assignee: ZHONGSHAN ZHONGYAN COSMETIC Co Ltd
Current assignee: ZHONGSHAN ZHONGYAN COSMETIC Co Ltd
Priority date: 2019-07-05
Filing date: 2019-07-05
Publication date: 2019-09-06

Abstract

The present invention proposes a kind of for the skin care item for repairing sensitive skin of releiving, it by mass percentage include following components: Ceramide Complex 5-15%, skin conditioning agent 1-10%, the emollient 5-15% of plant origin, the hyaluronic acid 0.08-0.12% of low molecular weight, glycine betaine 1.2-3%, polyol humectant 7.8-28%, thickener 0.1-0.8%, emulsifier 0.5-2% and water 35%-72%.The present invention can promote skin barrier function reparation and improve skin moisturizing ability, to reinforce barrier function, skin is reduced to the reactivity of environmental factor, skin is improved to the resistivity of environmental stimuli, reinforce moist epidermis, alleviate skin discomfort, improve sensitive and reactive skins comfort levels, is suitble to sensitive skin crowd long-time service.

Description

It is a kind of for the skin care item for repairing sensitive skin of releiving

Technical field

The present invention relates to cosmetic fields more particularly to a kind of for the skin care item for repairing sensitive skin of releiving.

Background technique

The pathological change of sensitive skin is that cuticula is thinning, causes skin moisturizing degree inadequate since cuticula is thinning, finally Cause the barrier function of skin excessively weak, environmental stimuli can not be resisted.Then the nerve fibre of skin is outer due to being often subject to Boundary's stimulation, so that it is easy to generate general red, fever, itch, shouting pain, the generation of the discomfort phenomenon such as erythema.Even smear skin care item Cannot be eased can generate stimulation because of some material compositions instead, aggravate allergic conditions.

40%~50% sebum is made of ceramide in the cuticula of skin, and ceramide is the master of intercellular matrix Part is wanted, is played an important role in the balance for keeping cuticula moisture.Ceramide has hydrone ability of associating by force very much, it Moisture of skin is maintained by forming reticular structure in cuticula, is conducive to repair skin barrier, improves skin sensitivity.But Ceramide is directly appended in cosmetics as dystectic oil soluble material using relatively difficult, and additive amount very by Limitation is easy that the stability for influencing integral formula is precipitated.In addition, discomfort only can only be alleviated from epidermal keratinocytes moisturizing, it cannot be into one Step repairs impaired skin.

Summary of the invention

To meet the skin care demand of sensitive skin crowd, repairing sensitive flesh, the present invention propose it is a kind of for releive repair it is quick Feel the skin care item of skin, promote skin barrier function reparation and improve skin moisturizing ability, to reinforce barrier function, reduces skin To the reactivity of environmental factor, skin is improved to the resistivity of environmental stimuli, reinforces moist epidermis, alleviates skin discomfort, change Kind sensitive and reactive skins comfort level, is suitble to sensitive skin crowd to be used for a long time.

The present invention propose it is a kind of for the skin care item for repairing sensitive skin of releiving, by mass percentage include following components: Ceramide Complex 5-15%, skin conditioning agent 1-10%, the emollient 5-15% of plant origin, low molecular weight hyalomitome Sour 0.08-0.12%, glycine betaine 1.2-3%, polyol humectant 7.8-28%, thickener 0.1-0.8%, emulsifier 0.5- 2% and water 35%-72%；

The Ceramide Complex, by its mass percent, including following components: dipropylene glycol 15-20%, glycerol 10-12%, hydrolecithin 3.0-4.5%, lysolecithin 0.1-0.5%, Cer EOS -3%, cholesterol 0.5-1%, Chelating agent 0.05-0.1%, 1,2- pentanediol 3-5%, excess water, the sum of each component is 100%；

The skin conditioning agent includes polypeptide active object, yeast extract, panthenol, tetrahydro methylpyrimidine carboxylic acid and spiny dogfish Alkane.

Preferably, the ceramide include Cer EOS, Cer NS, Cer NP, in Cer AP II Two or more.

Preferably, the mass percent of the skin care item of sensitive skin is repaired for releiving by described, the polypeptide active object Content be 0.05-0.15%, the content of yeast extract is 3-10%, and the content of the panthenol is 0.05-1.2%, described The content of tetrahydro methylpyrimidine carboxylic acid is 0.5-2%, and the content of the saualane is 0.3-0.8%.

Preferably, the polypeptide active object is myristyl aminobutyryl valyl amido butyric acid urea trifluoroacetate.

Preferably, it is 3KDa~10KDa that the molecular weight of the hyaluronic acid of the low molecular weight, which is average molecular weight,.

Preferably, the emollient of the plant origin includes jojoba seed oil, macadimia nut oil, Silybum Marianum Gaertn Seed Oil resin acid second One of ester, phytosterols oletate and tocopherol, two or more.It selects plant origin grease milder, reduces to skin The stimulation of skin.

Preferably, the polyol humectant includes dipropylene glycol, glycerol and 1,2- pentanediol.With Ceramide Complex In polyalcohol it is consistent, close the better phase melt of component.

Preferably, the emulsifier is the pure and mild cetearyl glucoside of cetearyl alcohol.

Preferably, described to repair the skin care item of sensitive skin for releiving, it further include thickener 0.1- by mass percentage 0.8%.The thickener is preferably polyacrylate cross-linked polymer -6.The skin care item can adjust viscosity and emulsification degree system For at dosage forms such as lotion, cream, frosts.

Beneficial effects of the present invention:

Provided by the present invention in the cosmetic composition for repairing sensitive skin of releiving, including

1, Ceramide Complex

The lipids such as exogenous supplement ceramide, cholesterol facilitate the perfect of impaired skin barrier function and restore. The Ceramide Complex voluntarily prepared contains the ceramide of high concentration polymorphic type, peomotes impaired skin barrier function Can improve and restore, improve skin and cause the symptoms such as allergy, redness, itch of sensitive skin to resist energy environmental stimuli Power.

2, endogenous promotes to repair ingredient

The active constituent of yeast extract is hydrolyzed yeast albumen, can high level activation epidermis lipid synthesis, such as neural acyl Amine and cholesterol repair the long-term aquation of dry skin, rebuild skin barrier.

Polypeptide active object (myristyl aminobutyryl valyl amido butyric acid urea trifluoroacetate) can activate TGF- Beta promotes hyaluronic acid in true epidermis to synthesize, strengthens collagenous fibres, enhances skin tightness, tight with fabulous skin Cause and moistening effect.

3, exogenous supplement repairs ingredient

Low-molecular-weight hyaluronic acid (average molecular weight 3KDa~10KDa) can be absorbed into inside skin and play preferably Moisturizing and barrier repair function.

Panthenol, molecular weight is smaller, and cuticula can be effectively penetrated into after being absorbed by the skin, and increases the hyaluronic acid in skin Content moisturizes the skin the cuticula on surface, plays the role of potent moisturizing, is effectively improved pachylosis, skin is made to become soft There is certain antiinflammation simultaneously.

Tetrahydro methylpyrimidine carboxylic acid has very strong hydrone complexing power, can make the water-bound of cell free.

Saualane be closest to human sebaceous a kind of lipid, affinity is strong, can melt with the sebum film of mankind itself for One forms one layer of natural barrier in skin surface.

Polypeptide active object, yeast extract, panthenol, tetrahydro methylpyrimidine carboxylic acid and saualane compounding are improved, and can be promoted Into the synthesis of the ceramide of skin itself, hyaluronic acid and other moisturizing ingredients.

The present invention organically combines Ceramide Complex and skin conditioning agent, emollient, moisturizer etc., synergistic, By inside and outside two kinds of approach, exogenous property supplement and endogenous promote the ceramide of skin itself to synthesize, and increase skin keratin The content of ceramide and hyaluronic acid in layer promotes skin barrier function reparation and improves skin moisturizing ability, to reinforce shielding Hinder function, reduce skin to the reactivity of environmental factor, improve skin to the resistivity of environmental stimuli, reinforce moist epidermis, Alleviate skin discomfort, improves sensitive and reactive skins comfort levels.

And by test, skin care item of the invention have safe and efficient barrier reparation and effect of releiving, sensitive skin people The symptoms such as skin sensitivity, furfur, tight, dry, itch are obviously improved after group's continuous use, and impaired skin barrier obtains quickly Effective to repair, percutaneous water loss reduces, and moisture content of skin significantly improves, and realization, which is safely and effectively releived, repairs sensitive skin Skin is suitble to sensitive skin crowd to be used for a long time.

Detailed description of the invention

Fig. 1 is the test result that the performance of keeping humidity of the embodiment of the present invention 1 is tested.

Fig. 2 is the test result through epidermis moisture loss rate of the embodiment of the present invention 1.

Fig. 3 releives for the embodiment of the present invention 1 repairs the test result of dry skin improvement degree in efficacy test.

Fig. 4 releives for the embodiment of the present invention 1 repairs the test result of tight feeling improvement degree in efficacy test.

Fig. 5 releives for the embodiment of the present invention 1 and repairs the test result of the coarse improvement degree of skin in efficacy test.

Fig. 6 releives for the embodiment of the present invention 1 repairs the test result that scurf in efficacy test peels off improvement degree.

Specific embodiment

As follows in conjunction with attached drawing, application scheme is further described:

Embodiment 1

It is a kind of for the skin care item for repairing sensitive skin of releiving, be made of by mass percentage the following table 1 recipe ingredient:

Table 1

Wherein, the M68 emulsifier of the emulsifier preferred France's match BIC Corp, main component are that cetearyl alcohol is pure and mild Cetearyl glucoside.

The Ceramide Complex is made of the following table 2 recipe ingredient by mass percentage:

Table 2

Component	Mass percent (%)
		Dipropylene glycol	20
Glycerol	10
		Hydrolecithin	4.5
Lysolecithin	0.1
		Cer NS	0.7
Cer NP	0.3
		Cholesterol	0.5
EDETATE SODIUM	0.1
		1,2- pentanediol	5
Water	Surplus

The preparation method of the Ceramide Complex, comprising the following steps:

1, Cer NS, Cer NP, cholesterol and glycerol are proportionally uniformly mixed, are heated on electric furnace molten Melt.Ceramide, the cholesterol dispersion effect in glycerol are optimal.

2, hydrolecithin and dipropylene glycol are proportionally uniformly mixed, are melted in 90 DEG C of water-baths.Hydrogenate lecithin Rouge dispersion effect in dipropylene glycol is optimal, be heated to 90 DEG C it is i.e. fusible be uniformly dispersed, avoid heating temperature is excessively high from will lead to Material jaundice, influences application of the compound in transparent skin-care product.

3, the melting that the melting mixing liquid of hydrolecithin and dipropylene glycol pours into ceramide, cholesterol and glycerol is mixed Close liquid in, kept the temperature in 90 DEG C of water-baths, stirring to Material it is transparent be it is uniformly mixed, obtain polyalcohol phase component.

4, lysolecithin, 1,2- pentanediol, EDETATE SODIUM, water are proportionally uniformly mixed and obtain water phase components, It is kept the temperature in 90 DEG C of water-baths.

5, the polyalcohol phase component is continued into 90 DEG C, Bian Junzhi of heat preservation, while being slowly added to the water phase components；Entirely Journey operates in 90 DEG C of water-baths, and homogeneous speed is 6000rpm, and homogeneous 5min can stop homogeneous.

6, Material is taken out after homogeneous, vacuum takes out high-pressure homogeneous (pressure 500bar) 5 times again after bubble, can be obtained ceramide Compound.

It is above-mentioned to repair the preparation method of the skin care item of sensitive skin for releiving, comprising the following steps:

A. take the container of clean dried that 55-65 DEG C of water, panthenol is added, stirring and dissolving to colourless transparent liquid is spare.

B. it takes the container of clean dried that dipropylene glycol is added, is while stirring crosslinked hyaluronic acid (sodium) and polyacrylate Polymer -6 is slowly added to, and continues stirring after addition 5-8 minutes to uniformly without bulk, spare.

C. it adds water in clean emulsion pot, is heated with stirring to 90 ± 2 DEG C or so, step A and step are added while stirring Liquid, the glycine betaine, hydrolecithin of rapid B preparation；Homogeneous 5~8 minutes is to being uniformly dissolved；75 ± 1 DEG C of stirring cooling, it is spare.

D. emulsifier, jojoba seed oil, phytosterols oletate, silybin oil acetoacetic ester, saualane are added clean In dry oil cauldron, be heated with stirring to 85 ± 2 DEG C to be completely dissolved uniformly it is spare.

E. by the oil in step D oil cauldron, mutually filtering is added in the emulsion pot of step C；Emulsification pot temperature is maintained at 75~80 DEG C, homogeneous 10~15 minutes are uniform to system emulsification.It is cooled to 63~68 DEG C, is added 1,2- pentanediol, homogeneous 3~5 minutes.It stirs Mix be cooled to 45 ± 1 DEG C it is spare.

F. it adds water in advance in the container of clean dried, while stirring by Ceramide Complex, yeast extract, more Peptide activity object, tetrahydro methylpyrimidine carboxylic acid are slowly added to, and continue stirring 5~8 minutes after addition to uniformly without blocky milky white Color liquid.

G. milky white liquid made from step F, glycerol are added in the emulsion pot of step E, are stirred 5~10 minutes, after Continuous stirring is cooled to 36~38 DEG C of inspection by sampling qualification filtering and dischargings, is made described and repairs the skin care of sensitive skin for releiving Product, the dosage form of the skin care item are face cream.

By it is obtained above be used to releive repair the skin care item of sensitive skin and be tested for the property

1, performance of keeping humidity is tested

Test method are as follows:

Find and filter out the subject of skin properties sensitivity, women 10 in 20~45 one full year of life of age.Subject makes It is each primary daily morning and evening with the face cream sample of embodiment 1, the sample of one piece of unitary coin-size is used in face, deactivates other Skin care item, respectively 3 days after using preceding and use, 7 days, 10 days, progress skin surface moisture content test in 14 days and calculate Skin surface water content growth rate.

Test results are shown in figure 1, it is known that the moisture content using subjects skin after the face cream of embodiment 1 gradually increases Add, skin moisture content increases 18% after two weeks, illustrates of the invention there is excellent skin-moisturizing, skin effect.

2, (TEWL) is tested through transepidermal water turnover rate

It is the parameter reused very much, skin sparing through function of the transepidermal water turnover rate test TEWL to assessment water moisturizing layer Layer is more intact, and the content of moisture content is higher, and the numerical value that skin moisture is lost TEWL is lower.

Test method:

It finds and filters out skin properties sensitivity, women 10 in 20~45 one full year of life of age.Subject uses embodiment 1 Sample, it is each primary daily morning and evening, use the sample of one piece of unitary coin-size in face, deactivate other skin care item, exist respectively Skin water loss TEWL test is carried out after a week using preceding and use.

Test results are shown in figure 2, and using one Zhou Yihou of face cream of embodiment 1, the skin barrier function of subject is obtained Certain reparation, transepidermal water loss rate drop to 9.26% by 12.05%, i.e. the water holding capacity of skin averagely improves 23.2%.Illustrate the present invention for repairing skin barrier, improving water lock performance has excellent effect.

3, it releives and repairs efficacy test

Test method: selecting the subject of 10 skin sensitivities to use the face cream of embodiment 1, each daily morning and evening to use once, often Secondary 2g deactivates other skin care item, and comparison uses latter week by way of questionnaire survey, and two weeks skin problems improve after use Situation.

In questionnaire survey to the description of skin condition scoring select to score 1 for skin problem clearly, 2 be skin problem Obvious, 3 is generally obvious for skin problem, and 4 be skin problem than less obvious, and 5 is unobvious for skin problem, i.e., score is got over High skin problem is more unobvious.

Test result participates in attached drawing 3-6:

(1) dry skin, average score rise to 3.21 by 2.61, improvement rate 23.26%.

(2) tight feeling, average score rise to 3.36 by 2.79, improvement rate 20.65%.

(3) skin is coarse, and average score rises to 4.03 by 3.61, improvement rate 11.76%.

(4) scurf peels off, and average score rises to 4.24 by 3.70, improvement rate 14.75%.

It can be seen from the above result that the skin problem (dry skin, tight feeling, skin are coarse, scurf peels off) of subject all obtains Effective improvement is arrived.

It is that above-mentioned preferred embodiment should be regarded as application scheme embodiment for example, all with application scheme thunder Same, approximate or technology deduction, replacement, improvement for making based on this etc., are regarded as the protection scope of this patent.

Claims

1. a kind of for the skin care item for repairing sensitive skin of releiving, which is characterized in that by mass percentage include following components: mind Through amide compound 5-15%, skin conditioning agent 1-10%, the emollient 5-15% of plant origin, low molecular weight hyaluronic acid 0.08-0.12%, glycine betaine 1.2-3%, polyol humectant 7.8-28%, thickener 0.1-0.8%, emulsifier 0.5- 2.5% and water 35%-72%；

The Ceramide Complex, by its mass percent, including following components: dipropylene glycol 15-20%, glycerol 10- 12%, hydrolecithin 3.0-4.5%, lysolecithin 0.1-0.5%, Cer EOS -3%, cholesterol 0.5-1%, chelating Agent 0.05-0.1%, 1,2- pentanediol 3-5%, excess water, the sum of each component is 100%；

The skin conditioning agent includes polypeptide active object, yeast extract, panthenol, tetrahydro methylpyrimidine carboxylic acid and saualane.

2. according to claim 1 repair the skin care item of sensitive skin for releiving, which is characterized in that the ceramide Including two or more in Cer EOS, Cer NS, Cer NP, Cer AP II.

3. according to claim 1 repair the skin care item of sensitive skin for releiving, which is characterized in that by described for relaxing The mass percent of the slow skin care item for repairing sensitive skin, the content of the polypeptide active object are 0.05-0.15%, and yeast extracts The content of object is 3-10%, and the content of the panthenol is 0.05-1.2%, and the content of the tetrahydro methylpyrimidine carboxylic acid is 0.5- 2%, the content of the saualane is 0.3-0.8%.

4. according to claim 1 repair the skin care item of sensitive skin for releiving, which is characterized in that the polypeptide active Object is myristyl aminobutyryl valyl amido butyric acid urea trifluoroacetate.

5. according to claim 1 repair the skin care item of sensitive skin for releiving, which is characterized in that the low molecular weight The molecular weight of hyaluronic acid be average molecular weight be 3KDa~10KDa.

6. according to claim 1 repair the skin care item of sensitive skin for releiving, which is characterized in that the plant origin Emollient include in jojoba seed oil, macadimia nut oil, silybin oil acetoacetic ester, phytosterols oletate and tocopherol It is a kind of, two or more.

7. according to claim 1 repair the skin care item of sensitive skin for releiving, which is characterized in that the polyalcohol is protected Humectant includes dipropylene glycol, glycerol and 1,2- pentanediol.

8. according to claim 1 repair the skin care item of sensitive skin for releiving, which is characterized in that the emulsifier packet Include the pure and mild cetearyl glucoside of cetearyl alcohol.

9. according to claim 1 repair the skin care item of sensitive skin for releiving, which is characterized in that the thickener packet Include polyacrylate cross-linked polymer -6.