CN105311600A - Medical gel having sterilizing and disinfecting functions - Google Patents
Medical gel having sterilizing and disinfecting functions Download PDFInfo
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Abstract
The invention discloses a medical gel having sterilizing and disinfecting functions. The medical gel is mainly prepared from the following medicinal raw materials in parts by weight: 10-18 parts of peppermint, 6-12 parts of lagenaria siceraria, 8-17 parts of concha arcae, 9-12 parts of tripterygium wilfordii, 7-12 parts of dried ginger, 13-16 parts of radix isatidis, 5-9 parts of rhizoma cimicifugae, 4-8 parts of gypsum, 10-15 parts of mung beans, 8-12 parts of exocarpium benincasae, 5-10 parts of rhizoma nelumbinis, 85-140 parts of sodium alginate, 10-20 parts of xanthan gum and 12-30 parts of anhydrous calcium chloride. The medical gel disclosed by the invention also has the excellent effects that the medical gel prepared by the invention is good in stability, rapid in transdermal absorption, non-irritant to skin and is capable of rapidly promoting wound healing.
Description
Technical field
The present invention relates to field of medical materials, particularly relate to a kind of medical gel with sterilizing effect.
Background technology
Nosocomial infection produces along with the appearance of hospital, and the common antibacterial of hospital infection has colon bacillus, Pseudomonas aeruginosa, staphylococcus aureus, Candida albicans etc., and along with antibiotic extensive application, multidrug resistant has appearred in antibacterial.The colon bacillus of producing beta-lactamase in the detection of hospital infection bacterium accounts for 74% of colon bacillus, methicillin-resistant staphylococcus aureus accounts for 76% of staphylococcus aureus, producing the Pseudomonas aeruginosa of beta-lactamase is the common Resistant strain of hospital, fungal infection recall rate presents the trend risen year by year, and fungus take Candida albicans as representative.Hospital infection extensively exists, and constitutes a serious threat to patient health.For guaranteeing patient medical safety, strengthening hospital infection management and having mentioned agenda and the important topic becoming modern hospital management research.
Hospital infection not only refers to the situation of patient in treatments period generation hospital infection clinically, and be also included within infection from hospital but just show the phenomenon of infection after leaving hospital, Surgical Operating Room is the section office occurred frequently of hospital infection always.Wound is situation very common in surgical process, and traumatic wounds has operative incision, burn, daily damage, decubital ulcer and infected wound etc.Clinically, the basic goal for the treatment of wound cures protopathy, accelerating wound healing.If when phenomenon is infected between wound convalescent period, wound surface appearance is red, swollen, hot, pain etc., whole body or local just useful antibiotic indication.Whether wound surface applies antibiotic, and arguement is more at present.There is cytotoxicity in local application to fibroblast in body, and delayed union.Also there are some researches show, as special infective wound surfaces such as mycete, anaerobe, tubercule bacillus, Pseudomonas aeruginosas, local application can reduce the toxic action of systemic administration to important organ, strengthens local anti-infective ability.Sterilization is by cutting off route of transmission to control the effective measures of nosocomial infection, along with progressively integrating with of the development of medical skill and China and the world, disinfection technology and theory are also being constantly updated, and traditional sterilizing methods, are not suitable with Development of Hospital and infection control demand.Therefore research and develop one can intercept pathogenic microorganism, suppressed or kill, reach the novel antibiotic material in medical use that effectively reduction body is fallen ill and have important practical significance.
Application publication number CN102526284A(application number 201210005596.5) Chinese invention patent document disclose a kind of gel and preparation method thereof with antiinflammatory, antipruritic, bactericidal action, be made up of the raw material of following weight portion: Flos Lonicerae (or Flos Lonicerae) 10-20 part, Fructus Kochiae 4-12 part, Radix Astragali 6-14 part, Radix Arnebiae (Radix Lithospermi) 1-4 part, Cortex Dictamni 8-16 part, Herba Menthae 1-4 part, Borneolum Syntheticum 0.001-2 part, Periostracum Cicadae 1-4 part, Talcum 8-16 part, Radix Glycyrrhizae 1-4 part, Mel 0.1-2 part.Application publication number CN103356738A(application number 201310305227.2) Chinese invention patent document disclose a kind of skin degerming gel and application thereof, be made up of the raw material of following mass fraction: chitosan 1.5%-6%, oligochitosan 1.5-10%, baicalin 2%-8%, chlorhexidine 0.5%-2%, sodium alginate are 0.5%-1.5%, agarose 2%-5%, Folium Menthae extract is 1.5%-5%.Application publication number CN103493852A(application number 201310442141.4) Chinese invention patent document disclose a kind of disinfection of Chinese drug gel, following parts by weight ingredient mixes: the extract of 60-70 part compound Chinese medicinal material, trichloro hydroxyl diphenyl ether 0.3-0.35, hydroxypropyl emthylcellulose 2-5, glycerol 1-3, ethanol 60-70, water surplus; The crude drug weight ratio of compound Chinese medicinal material is: bo-chrysanthemum 20-25, Radix Platycodonis 10-15, Herba Senecionis Scandentis 10-15, Herba Taraxaci 10-15, Galla Chinensis 5-10, Radix Gentianae 15-20, Fructus Xanthii 10-15, Folium Pini 15-20, Radix Angelicae Dahuricae 10-15, Radix Scutellariae 7-12, Rhizoma Smilacis Glabrae 15-20, Radix Bupleuri 15-20, Rhizoma Chuanxiong 7-12, Radix Cynanchi Paniculati 5-10, Rhizoma Osmundae 5-10.
Wound infection is one of Post operation common complication, and its consequence is wounds delay healing, disruption of wound, even causes systemic infection, how to carry out the sterilization of wound to minimizing postoperative wound infection important in inhibiting.Traditional sterilizing methods, be not suitable with Development of Hospital and infection control demand.Therefore research and develop one can intercept pathogenic microorganism, suppressed or kill, reach the novel antibiotic material in medical use that effectively reduction body is fallen ill and have important practical significance.
Summary of the invention
In order to make up above-mentioned deficiency, the object of the present invention is to provide a kind of medical gel with sterilizing effect, in efficacy of a drug infiltration, sterilizing, promotion wound healing etc., there is significant advantage, and preparation cost is low, preparation technology is simple.
Technical scheme of the present invention is:
There is the medical gel of sterilizing effect, be prepared from by the primary raw material medicine of following weight proportioning: Herba Menthae 10-18, calabash 6-12, Concha Arcae 8-17, Radix Tripterygii Wilfordii 9-12, Rhizoma Zingiberis 7-12, Radix Isatidis 13-16, Rhizoma Cimicifugae 5-9, Gypsum Fibrosum 4-8, Semen phaseoli radiati 10-15, Exocarpium Benincasae 8-12, Nodus Nelumbinis Rhizomatis 5-10, sodium alginate 85-140, xanthan gum 10-20, anhydrous calcium chloride 12-30.
In preferred scheme, Herba Menthae 12-16, calabash 8-10, Concha Arcae 11-14, Radix Tripterygii Wilfordii 10-11, Rhizoma Zingiberis 8.5-10.5, Radix Isatidis 14-15, Rhizoma Cimicifugae 6-8, Gypsum Fibrosum 5-7, Semen phaseoli radiati 11-14, Exocarpium Benincasae 9-11, Nodus Nelumbinis Rhizomatis 6.5-8.5, sodium alginate 100-125, xanthan gum 13-17, anhydrous calcium chloride 18-24.
Be more preferably, Herba Menthae 14, calabash 9, Concha Arcae 12.5, Radix Tripterygii Wilfordii 10.5, Rhizoma Zingiberis 9.5, Radix Isatidis 14.5, Rhizoma Cimicifugae 7, Gypsum Fibrosum 6, Semen phaseoli radiati 12.5, Exocarpium Benincasae 10, Nodus Nelumbinis Rhizomatis 7.5, sodium alginate 112, xanthan gum 15, anhydrous calcium chloride 20.
Have the preparation method of the medical gel of sterilizing effect, step is as follows:
(1) Herba Menthae and Rhizoma Cimicifugae mixing, be placed in Chinese medicament extracting device, take concentration as the alcoholic solution of 50% be solvent, wherein the amount of solvent is 2.5-4.5 times (amount of preferred solvent is 3.5 times of raw material dose) of raw material dose, reflux, extract, 30-46 minute (preferred reflux, extract, 38 minutes), filters, filtrate recycling ethanol, concentrating under reduced pressure becomes tan solid, for subsequent use;
(2) Rhizoma Zingiberis is placed in iron pan, above covers a less iron pan, blank sheet of paper is posted in the little the bottom of a pan, with yellow mud sealing pot limit, put on stove fire, upper ballast, mild and heavy respiration is calcining 15-25 minute (preferred mild and heavy respiration replaces calcining 20 minutes) alternately, baked wheaten cake of finally useing force is fired to blank sheet of paper flavescence brown, take out medical material, cool, be together ground into fine powder with Concha Arcae, cross 90-120 mesh sieve (preferred mistake 105 mesh sieve), for subsequent use;
(3) by calabash, Radix Tripterygii Wilfordii, Radix Isatidis, Semen phaseoli radiati, Exocarpium Benincasae and Nodus Nelumbinis Rhizomatis mixing, add the second distillation water soaking 3-5 hour second distillation water soaking of 5 times amount (preferably add 4 hours) of 4-6 times amount, then the Gypsum Fibrosum coarse powder with tiffany parcel is added, intense fire heated and boiled 3-5 minute (preferred intense fire heated and boiled 4 minutes), fire of larding speech with literary allusions is decocted 14-32 minute (fire of preferably larding speech with literary allusions decocts 23 minutes slowly) slowly, filter, step (2) gained mixing fine powders is added in filtrate, slow fire boiling 6-10 minute (preferred slow fire boiling 8 minutes), filter, when liquid to be filtered is cooled to 70-80 DEG C (when preferred liquid to be filtered is cooled to 75 DEG C), add activated carbon decolorizing, filter, filtrate reduced in volume is to 1/4 of original volume, add step (1) gained grease, mixing, via hole diameter is the microporous filter membrane filtration (preferred via hole diameter is the microporous filter membrane filtration of 6 μm) of 4-8 μm, obtain herb liquid, for subsequent use,
(4) anhydrous calcium chloride redistilled water is mixed with the solution (being preferably mixed with the solution that concentration is 4%) that concentration is 3%-5%, add olein and xanthan gum while stirring, be placed in the water-bath that temperature is 80 DEG C, sodium alginate and polyvinyl alcohol is added under stirring at low speed, obtained gel-type vehicle, for subsequent use;
(5) step (3) gained herb liquid is under agitation added in step (4) gained gel-type vehicle, add simultaneously permeation enhancers that antiseptic that content is 0.3%-0.7% and content are 0.5%-1.5% (preferably add content be 0.5% antiseptic and content be the permeation enhancers of 1.0%), mix homogeneously, pH to 3-7 is regulated with triethanolamine, then 60 DEG C of water bath with thermostatic control gelatinization reactions are placed in 10-26 minute (being preferably placed in 60 DEG C of water bath with thermostatic control gelatinization reactions 18 minutes), by reverse mould press mold cooling and shaping, obtain gel.
The above-mentioned preparation method with the medical gel of sterilizing effect, preferred scheme is, in step (3), the time of decolouring is 25-45 minute (time of preferred decolouring is 30-40 minute, and the time of the decolouring be more preferably is 35 minutes).
The above-mentioned preparation method with the medical gel of sterilizing effect, preferred scheme is, in step (4), the mass ratio of olein and xanthan gum is the mass ratio of the preferred olein of 3-6:1(and xanthan gum is 4-5:1, and the olein be more preferably and the mass ratio of xanthan gum are 4.5:1).
The above-mentioned preparation method with the medical gel of sterilizing effect, preferred scheme is, in step (4), the mass ratio of sodium alginate and polyvinyl alcohol is the mass ratio of the preferred sodium alginate of 5-7:1(and polyvinyl alcohol is 5.5-6.5:1, and the sodium alginate be more preferably and the mass ratio of polyvinyl alcohol are 6:1).
The above-mentioned preparation method with the medical gel of sterilizing effect, preferred scheme is, antiseptic described in step (5) to be the concentration be dissolved in propylene glycol be 5% ethyl hydroxybenzoate solution.
The above-mentioned preparation method with the medical gel of sterilizing effect, preferred scheme is, permeation enhancers described in step (5) is the concentration be dissolved in ethanol is the azone solution of 2.6%.
The above-mentioned preparation method with the medical gel of sterilizing effect, preferred scheme is, regulates pH to 4-6(preferably to regulate pH to 5 in step (5)).
The pharmacological effect of each crude drug is respectively:
Herba Menthae: base is former: be herb or the leaf of labiate Herba Menthae or family Herba Menthae.Chemical analysis: fresh leaf is containing volatile oil 0.8 ~ 1%, and scapus leaf is containing 1.3 ~ 2%.In oil, main constituent is menthol, content about 77 ~ 78%, and be secondly menthone, content is 8 ~ 12%, also containing menthyl acetate, camphene, limonene, isomenthone, pinene, piperitenone, resin and a small amount of tannin, rosmarinic acid.Pharmacological action: menthol topical application can control headache, neuralgia, pruritus etc.Be applied to skin, first have cool feeling, have slight thorn to burn later and feel.Nature and flavor: pungent are cool.Gui Jing: enter lung, Liver Channel.Function cures mainly: dispelling wind, and heat radiation, wards off dirty, removing toxic substances.Control affection due to external wind and heat, headache, conjunctival congestion, laryngopharynx swelling and pain, dyspepsia flatulence, aphtha, toothache, skin ulcer scabies, urticaria.
Calabash: base is former: this product is the dry seed of cucurbitaceous plant calabash.Nature and flavor: sour, puckery, temperature.Function cures mainly: antidiarrheal, draws and tells.For hematodiarrhoea, pneumonopathy, erythra.
Concha Arcae: base is former: be the shell of Carnis Arca inflata section animal Scapharca broughtonii, Tegillarca granosa or Scapharca subcrenata.Character: shell is fan-shaped or triangle, left and right two hull shape shape is identical, or left shell is a bit larger tham right shell.Long 2.5 ~ 8 centimetres, wide 2 ~ 6 centimetres.The back side is swelled, and have tens of directly stupefiedly to be radiated towards periphery by top as row of tiles on a roof shape, stupefied stricture of vagina obviously, forms by taupe is alternate with white.Nature and flavor: Gan Xian are flat.Gui Jing: enter liver, spleen channel.Function cures mainly: reduce phlegm, softening the hard mass, dissipating blood stasis, removing food stagnancy.Control accumulation of phlegm, stomachache, noisy, acid regurgitation, lump in the abdomen, scrofula, ulcerative gingivitis.
Radix Tripterygii Wilfordii: base is former: be root, the Ye Jihua of Celastraceae plant Radix Tripterygii Wilfordii.Chemical analysis: root throws away the alkaloids such as alkali, wilforgine, wilfortrine and wilfozine containing wilfordine, Radix Tripterygii Wilfordii.Pharmacological action: insecticidal action: the infusion of Radix Tripterygii Wilfordii and ethanol immersion all have the ability of poisoning Folium pyri star caterpillar and leaf folder; But its petroleum ether, ether or three oxygen methane immersion, then there is no killing ability.Toxicity: Radix Tripterygii Wilfordii is different to various animal toxicity, it is very large to the toxicity of people, dog, pig and insecticide, can occur poisoning even dead, but to sheep, rabbit, cat, Mus, fish but avirulence.The effect of Radix Tripterygii Wilfordii to body has two: one for the stimulation to gastrointestinal tract local; Two is the infringement to central nervous system (comprising Thalamus, midbrain, oblongata, cerebellum and spinal cord) after absorption, and causes the hemorrhage and necrosis of liver, the heart.Have meaning Radix Tripterygii Wilfordii mainly to poison the heart of animal, but to other smooth muscle and striped muscle also toxic, this is poisoning lethal reason.Poisoning rear emergency treatment is the conventional methods such as emetic, gastric lavage, coloclysis, catharsis, utilizes detoxification biology of Sanguis caprae seu ovis or rabbit stomach leachate not yet to determine.The toxic component of Radix Tripterygii Wilfordii can leach with ether, but through reduction, toxicity disappears completely.Nature and flavor: " Hunan medicine will ": " bitter, poison greatly." function cures mainly: " Hunan medicine will ": " parasite killing, antiinflammatory, removing toxic substances." Radix Tripterygii Wilfordii is a kind of hypertoxic medicine, especially skin zone's toxicity is very big, strictly should peel skin zone off during use, and the skin comprised in diploid skin and tree seam divides.
Rhizoma Zingiberis: base is former: be the dry rhizome of zingiber.Nature and flavor: pungent, heat.Gui Jing: enter spleen, stomach, lung meridian.Function cures mainly: warming middle-JIAO is by cold, and recuperating depleted YANG is promoted blood circulation.Control trusted subordinate's cold type of pain, vomit and diarrhoea, cold extremities faint pulse, breath with cough for cold time, anemofrigid-damp arthralgia, yang deficiency is told, be defeated in battle, hematochezia.The preparation method of Rhizoma Zingiberis Preparatum: get Rhizoma Zingiberis Recens block, put in pot urgent stir-fry of useing force and heave to foaming, crust is coke yellow, and interior in yellow, spray clear water is a little, takes out, dries.
Radix Isatidis: base is former: this product is the dry root of cruciferae isatis.Character: this product is cylindrical, slightly distortion.Surface light lark or light brown yellow, has vertical wrinkle, hole skin sample projection of growing crosswise and a supporting root trace.Root head slightly expands, the petiole residual base of visible dirty-green or the arrangement of burgundy colyliform and intensive verruca.Body is real, and matter is slightly soft. and section skin zone yellow-white, woody part is yellow.Nature and flavor: bitter, cold.Gui Jing: GUIXIN, stomach warp.Effect: heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving.Cure mainly: for maculae caused by violent heat pathogen, crimson tongue is purple dark, mumps, sore throat, scarlet fever, major part pestilence, erysipelas, carbuncle.
Rhizoma Cimicifugae: base is former: be the root stock of ranunculaceae plant Rhizoma Cimicifugae, Cimicifuga Dahurica and C.heracleifolia.Nature and flavor: sweet pungent micro-hardship are cool.Gui Jing: enter lung, spleen, stomach warp.Function cures mainly: yang invigorating, delivers, rash, removing toxic substances.Control seasonal epidemic pathogens epidemic disease, headache cold and heat, laryngalgia, aphtha, macule is not saturating; Sinking of QI of middle-JIAO, chronic diarrhea chronic dysentery, proctoptosis, women is collapsed, band, and uterus drops; Carbuncle sore tumefacting virus.
Gypsum Fibrosum: base is former: be the Ore of Sulfates mineral gypsum.Chemical analysis: main component is hydrous calcium sulfate.Wherein CaO be 32.5%, SO
2be 46.6%, H
2o is 20.9%, often has the impurity such as clay, sand grains, Organic substance, sulfide to be mixed in addition.Analyze according to Beijing medical college, outside sulfuric acid calcium, be still mingled with Fe++ and Mg++ of trace.Nature and flavor: Xin Gan, cold.Gui Jing: enter lung, stomach warp.Function cures mainly: life expelling pathogenic factors from muscles for clearing heat, relieving restlessness is quenched the thirst.Control calentura high fever not move back, vexed coma, delirium is gone mad, thirsty and dry pharynx, lung-heat dyspnea with rapid respiration, heatstroke spontaneous perspiration, stomach-fire headache, toothache, and hyperactivity of toxic heat, sends out speckle dermexanthesis, aphtha of the mouth and tongue.Forge deposited promoting tissue regeneration and ulcer healing.External treatment ulcer sores, bursts and does not close up, the burning hot wound of soup.
Semen phaseoli radiati: base is former: be the seed of leguminous plant Semen phaseoli radiati.Chemical analysis: every hectogram is containing protein 22.1 gram, 0.8 gram, fat, carbohydrate 59 grams, calcium 49 milligrams, 268 milligrams, phosphorus, ferrum 3.2 milligrams, carotene 0.22 milligram, thiamine 0.53 milligram, 0.12 milligram, riboflavin, nicotinic acid 1.8 milligrams.Protein master is Globulins, and in its composition, methionine, tryptophan and tyrosine are less.Phosphatidylcholine is had, PHOSPHATIDYL ETHANOLAMINE, phosphatidylinositols, phosphatidyl glycerol, Phosphatidylserine, phosphatidic acid in the phospholipid composition of Semen phaseoli radiati.Nature and flavor: sweet are cool.Gui Jing: enter the heart, stomach warp.Function cures mainly: heat-clearing and toxic substances removing, relieves summer heat, diuretic.Control summer-heat excessive thirst, edema, rush down profit, erysipelas, carbuncle, antipyretic poison of drug.
Exocarpium Benincasae: base is former: be the outside rind of cucurbitaceous plant Fructus Benincasae.Chemical analysis: content of wax class and resinous matter.Flesh is containing trigonelline, adenine etc.Nature and flavor: sweet are cool.Gui Jing: " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " enter spleen, lung two warp." function cures mainly: inducing diuresis to remove edema.Harness the river swollen, diarrhoea, carbuncle.
Nodus Nelumbinis Rhizomatis: base is former: be the joint portion of the rhizome of nymphaeaceae plant lotus.Chemical analysis: Nodus Nelumbinis Rhizomatis is containing tannin, asparagine.Nature and flavor: sweet puckery are flat.Gui Jing: " book on Chinese herbal medicine brief points ": " few the moon of starting with, bright, the JUE YIN meridian of foot sun." function cures mainly: hemostasis, dissipating blood stasis.Control hemoptysis, spit blood, epistaxis, hematuria, has blood in stool, dysentery, metrorrhagia.
Sodium alginate: be a kind of natural polysaccharide, has the stability needed for pharmaceutical preparation adjuvant, dissolubility, viscosity and safety.Can be made into thin film, for confection release packaging.Can be used for increasing blood volume and maintaining blood pressure, get rid of the whole body such as the histamine toxoid that produces and wound is lost blood, the stablizing of perioperatively blood circulation, bleeding profusely property shock, burn shock, hyperpyrexia and acute dysentery of burning and dewater, therapeutic effect is good.Also have and cholesterol is excreted, suppress Pb, Cd, Sr are absorbed by the body and protect gastrointestinal tract, whole intestinal, fat-reducing, hypoglycemic effect.Mainly on medicament be used as suspending agent, emulsifying agent, sticky dose, the capsule material etc. of microcapsule.Sodium alginate is a kind of macromolecular compound of high viscosity.The difference of it and starch, cellulose etc., being that it has carboxyl, is the high polyuronide that the aldehyde radical of beta-D-mannuronic acid is formed with glycosidic bond.Its functional character is as follows: (1) hydrophilic is strong, can dissolve, form the uniform solution of very thickness in cold water and warm water.(2) true solution formed has flexibility, homogeneity and other good characteristics that other analog are difficult to obtain.(3) there is the effect of very strong protecting colloid, strong to the emulsifying ability of oils and fats.(4) add the slaines such as aluminum, barium, calcium, copper, ferrum, lead, zinc, nickel in the solution, insoluble alginate will be generated.These slaines are buffer agents of phosphate, acetate etc. of sodium, potassium, can suppress, retarded coagulation.(5) pH value is 7 usually, in neutral, can adjust between 4-10.(6) be wire polyelectrolyte, can be made into tough fiber (alginate fiber) or thin film, have and prevent be full of cracks effect.(7) cohesiveness is little, is applicable to warp size, the demoulding etc.
Xanthan gum: xanthan gum is also known as Xanthan gum, HANSHENGJIAO, Xanthan Gum, it is a kind of monospore polysaccharide of generation of being fermented by false xanthomonas, be primary raw material by cabbage black rot xanthomonas campestris with carbohydrate, through aerobic fermentation biotechnology, cut off 1,6-glycosidic bond, after opening side chain, by the outer heteropolysaccharide of the acid born of the same parents of the one of Isosorbide-5-Nitrae-be bonded to straight chain composition.Xanthan gum be light yellow can flowing powder to white, be slightly with stink.Be soluble in hot water or cold water, solution neutral, resistance and freeze and thawing, be insoluble to ethanol.Chance aqueous dispersion, emulsifying become stable hydrophilic thick gel.Its functional characteristic and the purposes in medicine are: (1) xanthan gum solution has the full-bodied characteristic of low concentration (viscosity of 1% aqueous solution is equivalent to 100 times of gelatin), are a kind of thickening agents efficiently.(2) viscosity of xanthan gum solution can not variation with temperature and changing a lot, can viscosity B coefficent be there is because of heating in general polysaccharide, but the aqueous solution of xanthan gum viscosity between 10-80 DEG C has almost no change, even if the aqueous solution of low concentration still demonstrates stable high viscosity in wide temperature range.1% xanthan gum solution (containing 1% potassium chloride) is heated to 120 DEG C from 25 DEG C. and its viscosity only reduces by 3%.(3) xanthan gum solution is very stable to soda acid, is make its viscosity unaffected between 5-10 at PH.(4) in medicine, be mainly used as setting agent, suspending agent, wetting agent, there is thickening, attachment, lubrication.
The medical gel scientific formula having sterilizing effect provided by the invention, preparation method is simple, and products obtained therefrom is easy to use, be easy to carry.In addition, excellent results of the present invention also shows:
1,gained medical gel good stability of the present invention, Transdermal absorption are fast, non-stimulated and can promote wound healing rapidly to skin;
2,sodium alginate combines with Chinese traditional herbs by gained medical gel of the present invention, and formula is reasonable, and compatibility is accurate, refreshing fast clean, and bactericidal effect is excellent, and persistent is reliable for effect, without health risk;
3,medicine source is easy to get, and medical material is with low cost, can relieve patient ' s burden.
Accompanying drawing explanation
Fig. 1 is the medical gel weightlessness change schematic diagram in time that the present invention has sterilizing effect.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
embodiment 1there is the medical gel of sterilizing effect, be prepared from (35g/ part) by the primary raw material medicine of following weight proportioning: Herba Menthae 10 parts, 6 parts, calabash, Concha Arcae 8 parts, Radix Tripterygii Wilfordii 9 parts, Rhizoma Zingiberis 7 parts, Radix Isatidis 13 parts, Rhizoma Cimicifugae 5 parts, 4 parts, Gypsum Fibrosum, 10 parts, Semen phaseoli radiati, Exocarpium Benincasae 8 parts, Nodus Nelumbinis Rhizomatis 5 parts, sodium alginate 85 parts, xanthan gum 10 parts, anhydrous calcium chloride 12 parts.
The preparation method with the medical gel of sterilizing effect is:
(1) Herba Menthae and Rhizoma Cimicifugae mixing, being placed in Chinese medicament extracting device, take concentration as the alcoholic solution of 50% is solvent, and wherein the amount of solvent is 2.5 times of raw material dose, reflux, extract, 30 minutes, and filter, filtrate recycling ethanol, concentrating under reduced pressure becomes tan solid, for subsequent use;
(2) Rhizoma Zingiberis is placed in iron pan, above covers a less iron pan, blank sheet of paper is posted in the little the bottom of a pan, with yellow mud sealing pot limit, put on stove fire, upper ballast, mild and heavy respiration replaces calcining 15 minutes, baked wheaten cake of finally useing force is fired to blank sheet of paper flavescence brown, take out medical material, cool, be together ground into fine powder with Concha Arcae, cross 90 mesh sieves, for subsequent use;
(3) by calabash, Radix Tripterygii Wilfordii, Radix Isatidis, Semen phaseoli radiati, Exocarpium Benincasae and Nodus Nelumbinis Rhizomatis mixing, add the second distillation water soaking 3 hours of 4 times amount, then the Gypsum Fibrosum coarse powder with tiffany parcel is added, intense fire heated and boiled 3 minutes, fire of larding speech with literary allusions decocts 14 minutes slowly, filter, step (2) gained mixing fine powders is added in filtrate, slow fire boiling 6 minutes, filter, when liquid to be filtered is cooled to 70 DEG C, add activated carbon decolorizing 25 minutes, filter, filtrate reduced in volume is to 1/4 of original volume, add step (1) gained grease, mixing, via hole diameter is the microporous filter membrane filtration of 4 μm, obtain herb liquid, for subsequent use,
(4) anhydrous calcium chloride redistilled water is mixed with the solution (being preferably mixed with the solution that concentration is 4%) that concentration is 3%-5%, add olein and xanthan gum (mass ratio of olein and xanthan gum is 3:1) while stirring, be placed in the water-bath that temperature is 80 DEG C, sodium alginate and polyvinyl alcohol (mass ratio of sodium alginate and polyvinyl alcohol is 5:1) is added under stirring at low speed, obtained gel-type vehicle, for subsequent use;
(5) step (3) gained herb liquid is under agitation added in step (4) gained gel-type vehicle, add simultaneously content be 0.3% the antiseptic ethyl hydroxybenzoate solution of 5% (antiseptic to be the concentration be dissolved in propylene glycol be) and content be 0.5% permeation enhancers (permeation enhancers is the concentration be dissolved in ethanol is the azone solution of 2.6%), mix homogeneously, pH to 3 is regulated with triethanolamine, then 60 DEG C of water bath with thermostatic control gelatinization reactions are placed in 10 minutes, by reverse mould press mold cooling and shaping, obtain gel.
The using method that gained of the present invention has the medical gel of sterilizing effect is: the gel rubber plaster getting appropriate size spreads on affected part, within two days, changes once.
typical case one: Zhao XX, man, 36 years old, teacher.Mr. Zhao is a university chemistry teacher, on a laboratory, because certain the improper operating board that causes of classmate's agent treated is on fire, Mr. Zhao burns beyond the back of the hand in the process of fire extinguishing, and after school infirmary is treated, traumatic condition is controlled, after three days, Mr. Zhao feels that wound is infected, and wound is red and swollen, pain, with heating paresthesia, be that false unicellular bacterium infects on inspection.After smearing antibiotic therapy, symptom has no alleviation.Then to our hospital on May 11st, 2012.Check that patient wound is really because bacteriological infection causes, agree to use the present embodiment gained to have the medical gel of sterilizing effect through patient, treatment two days later, patient affected part redness obviously disappears, pain relief, and continual cure is after four days, affected part wound is obviously formed a scab, wound surface is dry, without red and swollen, without pain symptom.During medication, patient is without other uncomfortable reactions.
embodiment 2there is the medical gel of sterilizing effect, be prepared from (15g/ part) by the primary raw material medicine of following weight proportioning: Herba Menthae 18 parts, 12 parts, calabash, Concha Arcae 17 parts, Radix Tripterygii Wilfordii 12 parts, Rhizoma Zingiberis 12 parts, Radix Isatidis 16 parts, Rhizoma Cimicifugae 9 parts, 8 parts, Gypsum Fibrosum, 15 parts, Semen phaseoli radiati, Exocarpium Benincasae 12 parts, Nodus Nelumbinis Rhizomatis 10 parts, sodium alginate 140 parts, xanthan gum 20 parts, anhydrous calcium chloride 30 parts.
The preparation method with the medical gel of sterilizing effect is:
(1) Herba Menthae and Rhizoma Cimicifugae mixing, being placed in Chinese medicament extracting device, take concentration as the alcoholic solution of 50% is solvent, and wherein the amount of solvent is 4.5 times of raw material dose, reflux, extract, 46 minutes, and filter, filtrate recycling ethanol, concentrating under reduced pressure becomes tan solid, for subsequent use;
(2) Rhizoma Zingiberis is placed in iron pan, above covers a less iron pan, blank sheet of paper is posted in the little the bottom of a pan, with yellow mud sealing pot limit, put on stove fire, upper ballast, mild and heavy respiration replaces calcining 25 minutes, baked wheaten cake of finally useing force is fired to blank sheet of paper flavescence brown, take out medical material, cool, be together ground into fine powder with Concha Arcae, cross 120 mesh sieves, for subsequent use;
(3) by calabash, Radix Tripterygii Wilfordii, Radix Isatidis, Semen phaseoli radiati, Exocarpium Benincasae and Nodus Nelumbinis Rhizomatis mixing, add the second distillation water soaking 5 hours of 6 times amount, then the Gypsum Fibrosum coarse powder with tiffany parcel is added, intense fire heated and boiled 5 minutes, fire of larding speech with literary allusions decocts 32 minutes slowly, filter, step (2) gained mixing fine powders is added in filtrate, slow fire boiling 10 minutes, filter, when liquid to be filtered is cooled to 80 DEG C, add activated carbon decolorizing 45 minutes, filter, filtrate reduced in volume is to 1/4 of original volume, add step (1) gained grease, mixing, via hole diameter is the microporous filter membrane filtration of 8 μm, obtain herb liquid, for subsequent use,
(4) anhydrous calcium chloride redistilled water is mixed with the solution (being preferably mixed with the solution that concentration is 4%) that concentration is 3%-5%, add olein and xanthan gum (mass ratio of olein and xanthan gum is 6:1) while stirring, be placed in the water-bath that temperature is 80 DEG C, sodium alginate and polyvinyl alcohol (mass ratio of sodium alginate and polyvinyl alcohol is 7:1) is added under stirring at low speed, obtained gel-type vehicle, for subsequent use;
(5) step (3) gained herb liquid is under agitation added in step (4) gained gel-type vehicle, add simultaneously content be 0.7% the antiseptic ethyl hydroxybenzoate solution of 5% (antiseptic to be the concentration be dissolved in propylene glycol be) and content be 1.5% permeation enhancers (permeation enhancers is the concentration be dissolved in ethanol is the azone solution of 2.6%), mix homogeneously, pH to 7 is regulated with triethanolamine, then 60 DEG C of water bath with thermostatic control gelatinization reactions are placed in 26 minutes, by reverse mould press mold cooling and shaping, obtain gel.
The using method that gained of the present invention has the medical gel of sterilizing effect is: the gel rubber plaster getting appropriate size spreads on affected part, within two days, changes once.
embodiment 3there is the medical gel of sterilizing effect, be prepared from (30g/ part) by the primary raw material medicine of following weight proportioning: Herba Menthae 12 parts, 8 parts, calabash, Concha Arcae 11 parts, Radix Tripterygii Wilfordii 10 parts, Rhizoma Zingiberis 8.5 parts, Radix Isatidis 14 parts, Rhizoma Cimicifugae 6 parts, 5 parts, Gypsum Fibrosum, 11 parts, Semen phaseoli radiati, Exocarpium Benincasae 9 parts, Nodus Nelumbinis Rhizomatis 6.5 parts, sodium alginate 100 parts, xanthan gum 13 parts, anhydrous calcium chloride 18 parts.
The preparation method with the medical gel of sterilizing effect is:
(1) Herba Menthae and Rhizoma Cimicifugae mixing, being placed in Chinese medicament extracting device, take concentration as the alcoholic solution of 50% is solvent, and wherein the amount of solvent is 3 times of raw material dose, reflux, extract, 34 minutes, and filter, filtrate recycling ethanol, concentrating under reduced pressure becomes tan solid, for subsequent use;
(2) Rhizoma Zingiberis is placed in iron pan, above covers a less iron pan, blank sheet of paper is posted in the little the bottom of a pan, with yellow mud sealing pot limit, put on stove fire, upper ballast, mild and heavy respiration replaces calcining 18 minutes, baked wheaten cake of finally useing force is fired to blank sheet of paper flavescence brown, take out medical material, cool, be together ground into fine powder with Concha Arcae, cross 100 mesh sieves, for subsequent use;
(3) by calabash, Radix Tripterygii Wilfordii, Radix Isatidis, Semen phaseoli radiati, Exocarpium Benincasae and Nodus Nelumbinis Rhizomatis mixing, add the second distillation water soaking 3.5 hours of 4.5 times amount, then the Gypsum Fibrosum coarse powder with tiffany parcel is added, intense fire heated and boiled 4 minutes, fire of larding speech with literary allusions decocts 18 minutes slowly, filter, step (2) gained mixing fine powders is added in filtrate, slow fire boiling 7 minutes, filter, when liquid to be filtered is cooled to 73 DEG C, add activated carbon decolorizing 30 minutes, filter, filtrate reduced in volume is to 1/4 of original volume, add step (1) gained grease, mixing, via hole diameter is the microporous filter membrane filtration of 5 μm, obtain herb liquid, for subsequent use,
(4) anhydrous calcium chloride redistilled water is mixed with the solution that concentration is 3.5%, add olein and xanthan gum (mass ratio of olein and xanthan gum is 4:1) while stirring, be placed in the water-bath that temperature is 80 DEG C, sodium alginate and polyvinyl alcohol (mass ratio of sodium alginate and polyvinyl alcohol is 5.5:1) is added under stirring at low speed, obtained gel-type vehicle, for subsequent use;
(5) step (3) gained herb liquid is under agitation added in step (4) gained gel-type vehicle, add simultaneously content be 0.4% the antiseptic ethyl hydroxybenzoate solution of 5% (antiseptic to be the concentration be dissolved in propylene glycol be) and content be 0.8% permeation enhancers (permeation enhancers is the concentration be dissolved in ethanol is the azone solution of 2.6%), mix homogeneously, pH to 4 is regulated with triethanolamine, then 60 DEG C of water bath with thermostatic control gelatinization reactions are placed in 14 minutes, by reverse mould press mold cooling and shaping, obtain gel.
The using method that gained of the present invention has the medical gel of sterilizing effect is: the gel rubber plaster getting appropriate size spreads on affected part, within two days, changes once.
embodiment 4there is the medical gel of sterilizing effect, be prepared from (20g/ part) by the primary raw material medicine of following weight proportioning: Herba Menthae 16 parts, 10 parts, calabash, Concha Arcae 14 parts, Radix Tripterygii Wilfordii 11 parts, Rhizoma Zingiberis 10.5 parts, Radix Isatidis 15 parts, Rhizoma Cimicifugae 8 parts, 7 parts, Gypsum Fibrosum, 14 parts, Semen phaseoli radiati, Exocarpium Benincasae 11 parts, Nodus Nelumbinis Rhizomatis 8.5 parts, sodium alginate 125 parts, xanthan gum 17 parts, anhydrous calcium chloride 24 parts.
The preparation method with the medical gel of sterilizing effect is:
(1) Herba Menthae and Rhizoma Cimicifugae mixing, being placed in Chinese medicament extracting device, take concentration as the alcoholic solution of 50% is solvent, and wherein the amount of solvent is 4 times of raw material dose, reflux, extract, 42 minutes, and filter, filtrate recycling ethanol, concentrating under reduced pressure becomes tan solid, for subsequent use;
(2) Rhizoma Zingiberis is placed in iron pan, above covers a less iron pan, blank sheet of paper is posted in the little the bottom of a pan, with yellow mud sealing pot limit, put on stove fire, upper ballast, mild and heavy respiration replaces calcining 22 minutes, baked wheaten cake of finally useing force is fired to blank sheet of paper flavescence brown, take out medical material, cool, be together ground into fine powder with Concha Arcae, cross 110 mesh sieves, for subsequent use;
(3) by calabash, Radix Tripterygii Wilfordii, Radix Isatidis, Semen phaseoli radiati, Exocarpium Benincasae and Nodus Nelumbinis Rhizomatis mixing, add the second distillation water soaking 4.5 hours of 5.5 times amount, then the Gypsum Fibrosum coarse powder with tiffany parcel is added, intense fire heated and boiled 4 minutes, fire of larding speech with literary allusions decocts 28 minutes slowly, filter, step (2) gained mixing fine powders is added in filtrate, slow fire boiling 9 minutes, filter, when liquid to be filtered is cooled to 77 DEG C, add activated carbon decolorizing 40 minutes, filter, filtrate reduced in volume is to 1/4 of original volume, add step (1) gained grease, mixing, via hole diameter is the microporous filter membrane filtration of 7 μm, obtain herb liquid, for subsequent use,
(4) anhydrous calcium chloride redistilled water is mixed with the solution that concentration is 4.5%, add olein and xanthan gum (mass ratio of olein and xanthan gum is 5:1) while stirring, be placed in the water-bath that temperature is 80 DEG C, sodium alginate and polyvinyl alcohol (mass ratio of sodium alginate and polyvinyl alcohol is 6.5:1) is added under stirring at low speed, obtained gel-type vehicle, for subsequent use;
(5) step (3) gained herb liquid is under agitation added in step (4) gained gel-type vehicle, add simultaneously content be 0.6% the antiseptic ethyl hydroxybenzoate solution of 5% (antiseptic to be the concentration be dissolved in propylene glycol be) and content be 1.2% permeation enhancers (permeation enhancers is the concentration be dissolved in ethanol is the azone solution of 2.6%), mix homogeneously, pH to 6 is regulated with triethanolamine, then 60 DEG C of water bath with thermostatic control gelatinization reactions are placed in 22 minutes, by reverse mould press mold cooling and shaping, obtain gel.
The using method that gained of the present invention has the medical gel of sterilizing effect is: the gel rubber plaster getting appropriate size spreads on affected part, within two days, changes once.
typical case two: an XX, man, 31 years old, workman.Patient bleeds because operate miss causes the right hand to be stirred wound by machine at work in JIUYUE in 2013 on the 3rd, swelling, is worked together promptly to be sent to me and institute to treat.After operative treatment the 3rd day, finding that there is light courageous and upright secretions during Wound during Dressing Change and flow out, was Pseudomonas aeruginosa through antibacterial culturing, confirm wound infection, after patient and family members agree to, the medical gel using the present embodiment gained to have sterilizing effect sticks in infected wound, two days later, affected part infection symptoms is obviously alleviated, after four days, affected part infection symptoms disappears, and antibacterial culturing is negative, and affected part drying is aseptic, skin color recovers normal, and period patient is without any discomfort symptom.
embodiment 5there is the medical gel of sterilizing effect, be prepared from (25g/ part) by the primary raw material medicine of following weight proportioning: Herba Menthae 14 parts, 9 parts, calabash, Concha Arcae 12.5 parts, Radix Tripterygii Wilfordii 10.5 parts, Rhizoma Zingiberis 9.5 parts, Radix Isatidis 14.5 parts, Rhizoma Cimicifugae 7 parts, 6 parts, Gypsum Fibrosum, 12.5 parts, Semen phaseoli radiati, Exocarpium Benincasae 10 parts, Nodus Nelumbinis Rhizomatis 7.5 parts, sodium alginate 112 parts, xanthan gum 15 parts, anhydrous calcium chloride 20 parts.
The preparation method with the medical gel of sterilizing effect is:
(1) Herba Menthae and Rhizoma Cimicifugae mixing, being placed in Chinese medicament extracting device, take concentration as the alcoholic solution of 50% is solvent, and wherein the amount of solvent is 3.5 times of raw material dose, reflux, extract, 38 minutes, and filter, filtrate recycling ethanol, concentrating under reduced pressure becomes tan solid, for subsequent use;
(2) Rhizoma Zingiberis is placed in iron pan, above covers a less iron pan, blank sheet of paper is posted in the little the bottom of a pan, with yellow mud sealing pot limit, put on stove fire, upper ballast, mild and heavy respiration replaces calcining 20 minutes, baked wheaten cake of finally useing force is fired to blank sheet of paper flavescence brown, take out medical material, cool, be together ground into fine powder with Concha Arcae, cross 105 mesh sieves, for subsequent use;
(3) by calabash, Radix Tripterygii Wilfordii, Radix Isatidis, Semen phaseoli radiati, Exocarpium Benincasae and Nodus Nelumbinis Rhizomatis mixing, add the second distillation water soaking 4 hours of 5 times amount, then the Gypsum Fibrosum coarse powder with tiffany parcel is added, intense fire heated and boiled 4 minutes, fire of larding speech with literary allusions decocts 23 minutes slowly, filter, step (2) gained mixing fine powders is added in filtrate, slow fire boiling 8 minutes, filter, when liquid to be filtered is cooled to 75 DEG C, add activated carbon decolorizing 35 minutes, filter, filtrate reduced in volume is to 1/4 of original volume, add step (1) gained grease, mixing, via hole diameter is the microporous filter membrane filtration of 6 μm, obtain herb liquid, for subsequent use,
(4) anhydrous calcium chloride redistilled water is mixed with the solution that concentration is 4%, add olein and xanthan gum (mass ratio of olein and xanthan gum is 4.5:1) while stirring, be placed in the water-bath that temperature is 80 DEG C, sodium alginate and polyvinyl alcohol (mass ratio of sodium alginate and polyvinyl alcohol is 6:1) is added under stirring at low speed, obtained gel-type vehicle, for subsequent use;
(5) step (3) gained herb liquid is under agitation added in step (4) gained gel-type vehicle, add simultaneously content be 0.5% the antiseptic ethyl hydroxybenzoate solution of 5% (antiseptic to be the concentration be dissolved in propylene glycol be) and content be 1.0% permeation enhancers (permeation enhancers is the concentration be dissolved in ethanol is the azone solution of 2.6%), mix homogeneously, pH to 5 is regulated with triethanolamine, then 60 DEG C of water bath with thermostatic control gelatinization reactions are placed in 18 minutes, by reverse mould press mold cooling and shaping, obtain gel.
The using method that gained of the present invention has the medical gel of sterilizing effect is: the gel rubber plaster getting appropriate size spreads on affected part, within two days, changes once.
experimental example 1:gained of the present invention has antibacterial experiment in vitro research and the external degradation experimentation of the medical gel of sterilizing effect:
1, antibacterial experiment in vitro
Employing broth microdilution antifungal susceptibility test measures: medical gel gained of the present invention with sterilizing effect is placed in 80 DEG C of waters bath with thermostatic control, drip sterilized water while stirring and be mixed with the sample solution that concentration is 3.5-150 μ g/mL, test group is made up of following test strain: escherichia coli, staphylococcus aureus, bacillus pyocyaneus, streptococcus pneumoniae.Positive control drug is Roxithromycin.Minimal inhibitory concentration (MIC) with the compound concentration of anti-bacteria visible growth for least concentration.Result is as shown in table 1.
Table 1 medical gel of the present invention and contrast medicine are to the minimum inhibitory concentration result of four kinds of bacterial strains
2, external degradation experiment
(1) pretreatment of sample: medical gel gained of the present invention with sterilizing effect makes long 1.0cm, the short cylinder of diameter 0.3cm, and use normal saline oscillation cleaning, ethylene oxide sterilizing is for subsequent use;
(2) extracorporeal hydrolysis experiment: will be embedded in the thick glass cotton of 3.0-4.0mm after the sample correct amount prepared, it is in the culture dish of 120mm that whole system is placed on diameter, add the PBS buffer (pH=7.4) that 120mL prepares, gel is made to be immersed in PBS buffer completely, then be placed on by the culture dish that sample is housed in 37 DEG C of constant temperature ovens, constant temperature is placed, and samples after different intervals, deionized water rinsing, carries out weight loss determining after lyophilization.Rate of weight loss is by formula L=(W
0-W
t)/W
0× 100% calculates, wherein W
0quality before degraded, W
tit is the quality after degraded different time.Result as shown in Figure 1.
3, interpretation of result
As shown in Table 1, the medical gel that the present invention has sterilizing effect all has stronger bacteriostatic activity to escherichia coli, staphylococcus aureus, bacillus pyocyaneus and streptococcus pneumoniae, be wherein 4.61 μ g/mL to the minimal inhibitory concentration (MIC) of staphylococcus aureus, and contrast medicine Roxithromycin (MIC=4.37 μ g/mL) there is suitable bacteriostasis.Show (Fig. 1) by the experimental result of external degradation characteristic, belong to demurrage at 0-30d, rate of weight loss about 22%, but has spent demurrage, and weight reduces rapidly, and after 50d, rate of weight loss is up to 70%.
Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. there is the medical gel of sterilizing effect, it is characterized in that, be prepared from by the primary raw material medicine of following weight proportioning: Herba Menthae 10-18, calabash 6-12, Concha Arcae 8-17, Radix Tripterygii Wilfordii 9-12, Rhizoma Zingiberis 7-12, Radix Isatidis 13-16, Rhizoma Cimicifugae 5-9, Gypsum Fibrosum 4-8, Semen phaseoli radiati 10-15, Exocarpium Benincasae 8-12, Nodus Nelumbinis Rhizomatis 5-10, sodium alginate 85-140, xanthan gum 10-20, anhydrous calcium chloride 12-30.
2. there is the medical gel of sterilizing effect as claimed in claim 1, it is characterized in that, be prepared from by the primary raw material medicine of following weight proportioning: Herba Menthae 12-16, calabash 8-10, Concha Arcae 11-14, Radix Tripterygii Wilfordii 10-11, Rhizoma Zingiberis 8.5-10.5, Radix Isatidis 14-15, Rhizoma Cimicifugae 6-8, Gypsum Fibrosum 5-7, Semen phaseoli radiati 11-14, Exocarpium Benincasae 9-11, Nodus Nelumbinis Rhizomatis 6.5-8.5, sodium alginate 100-125, xanthan gum 13-17, anhydrous calcium chloride 18-24.
3. there is the medical gel of sterilizing effect as claimed in claim 1, it is characterized in that, be prepared from by the primary raw material medicine of following weight proportioning: Herba Menthae 14, calabash 9, Concha Arcae 12.5, Radix Tripterygii Wilfordii 10.5, Rhizoma Zingiberis 9.5, Radix Isatidis 14.5, Rhizoma Cimicifugae 7, Gypsum Fibrosum 6, Semen phaseoli radiati 12.5, Exocarpium Benincasae 10, Nodus Nelumbinis Rhizomatis 7.5, sodium alginate 112, xanthan gum 15, anhydrous calcium chloride 20.
4. the preparation method with the medical gel of sterilizing effect as described in as arbitrary in claim 1-3, it is characterized in that, step is as follows:
(1) Herba Menthae and Rhizoma Cimicifugae mixing, be placed in Chinese medicament extracting device, take concentration as the alcoholic solution of 50% be solvent, wherein the amount of solvent is 2.5-4.5 times (amount of preferred solvent is 3.5 times of raw material dose) of raw material dose, reflux, extract, 30-46 minute (preferred reflux, extract, 38 minutes), filters, filtrate recycling ethanol, concentrating under reduced pressure becomes tan solid, for subsequent use;
(2) Rhizoma Zingiberis is placed in iron pan, above covers a less iron pan, blank sheet of paper is posted in the little the bottom of a pan, with yellow mud sealing pot limit, put on stove fire, upper ballast, mild and heavy respiration is calcining 15-25 minute (preferred mild and heavy respiration replaces calcining 20 minutes) alternately, baked wheaten cake of finally useing force is fired to blank sheet of paper flavescence brown, take out medical material, cool, be together ground into fine powder with Concha Arcae, cross 90-120 mesh sieve (preferred mistake 105 mesh sieve), for subsequent use;
(3) by calabash, Radix Tripterygii Wilfordii, Radix Isatidis, Semen phaseoli radiati, Exocarpium Benincasae and Nodus Nelumbinis Rhizomatis mixing, add the second distillation water soaking 3-5 hour second distillation water soaking of 5 times amount (preferably add 4 hours) of 4-6 times amount, then the Gypsum Fibrosum coarse powder with tiffany parcel is added, intense fire heated and boiled 3-5 minute (preferred intense fire heated and boiled 4 minutes), fire of larding speech with literary allusions is decocted 14-32 minute (fire of preferably larding speech with literary allusions decocts 23 minutes slowly) slowly, filter, step (2) gained mixing fine powders is added in filtrate, slow fire boiling 6-10 minute (preferred slow fire boiling 8 minutes), filter, when liquid to be filtered is cooled to 70-80 DEG C (when preferred liquid to be filtered is cooled to 75 DEG C), add activated carbon decolorizing, filter, filtrate reduced in volume is to 1/4 of original volume, add step (1) gained grease, mixing, via hole diameter is the microporous filter membrane filtration (preferred via hole diameter is the microporous filter membrane filtration of 6 μm) of 4-8 μm, obtain herb liquid, for subsequent use,
(4) anhydrous calcium chloride redistilled water is mixed with the solution (being preferably mixed with the solution that concentration is 4%) that concentration is 3%-5%, add olein and xanthan gum while stirring, be placed in the water-bath that temperature is 80 DEG C, sodium alginate and polyvinyl alcohol is added under stirring at low speed, obtained gel-type vehicle, for subsequent use;
(5) step (3) gained herb liquid is under agitation added in step (4) gained gel-type vehicle, add simultaneously permeation enhancers that antiseptic that content is 0.3%-0.7% and content are 0.5%-1.5% (preferably add content be 0.5% antiseptic and content be the permeation enhancers of 1.0%), mix homogeneously, pH to 3-7 is regulated with triethanolamine, then 60 DEG C of water bath with thermostatic control gelatinization reactions are placed in 10-26 minute (being preferably placed in 60 DEG C of water bath with thermostatic control gelatinization reactions 18 minutes), by reverse mould press mold cooling and shaping, obtain gel.
5. the preparation method with the medical gel of sterilizing effect according to claim 4, it is characterized in that, in step (3), the time of decolouring is 25-45 minute (time of preferred decolouring is 30-40 minute, and the time of the decolouring be more preferably is 35 minutes).
6. the preparation method with the medical gel of sterilizing effect according to claim 4, it is characterized in that, in step (4), the mass ratio of olein and xanthan gum is the mass ratio of the preferred olein of 3-6:1(and xanthan gum is 4-5:1, and the olein be more preferably and the mass ratio of xanthan gum are 4.5:1).
7. the preparation method with the medical gel of sterilizing effect according to claim 4, it is characterized in that, in step (4), the mass ratio of sodium alginate and polyvinyl alcohol is the mass ratio of the preferred sodium alginate of 5-7:1(and polyvinyl alcohol is 5.5-6.5:1, and the sodium alginate be more preferably and the mass ratio of polyvinyl alcohol are 6:1).
8. the preparation method with the medical gel of sterilizing effect according to claim 4, is characterized in that, antiseptic described in step (5) to be the concentration be dissolved in propylene glycol be 5% ethyl hydroxybenzoate solution.
9. the preparation method with the medical gel of sterilizing effect according to claim 4, is characterized in that, permeation enhancers described in step (5) is the concentration be dissolved in ethanol is the azone solution of 2.6%.
10. the preparation method with the medical gel of sterilizing effect according to claim 4, is characterized in that, regulates pH to 4-6(preferably to regulate pH to 5 in step (5)).
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106215142A (en) * | 2016-08-10 | 2016-12-14 | 张家港市协和医疗器械有限公司 | A kind of Chinese medicine medical disinfection gel |
| CN110179589A (en) * | 2019-05-31 | 2019-08-30 | 重庆百亚卫生用品股份有限公司 | A kind of pants type paper diaper of adjustable waist |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106215142A (en) * | 2016-08-10 | 2016-12-14 | 张家港市协和医疗器械有限公司 | A kind of Chinese medicine medical disinfection gel |
| CN110179589A (en) * | 2019-05-31 | 2019-08-30 | 重庆百亚卫生用品股份有限公司 | A kind of pants type paper diaper of adjustable waist |
| CN110179589B (en) * | 2019-05-31 | 2021-06-04 | 重庆百亚卫生用品股份有限公司 | Trousers type paper diaper with adjustable waistline |
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Application publication date: 20160210 |