CN110141526A - A kind of moisture-keeping crease-shedding lotion and preparation method thereof - Google Patents
A kind of moisture-keeping crease-shedding lotion and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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Abstract
A kind of moisture-keeping crease-shedding lotion and preparation method thereof belongs to cosmetic configuration product technical field, the component including following parts by weight: hydroxycitric acid, and 4 ~ 6 parts;Salicylic acid, 3 ~ 4 parts;And pH to 5 ~ 8 is adjusted using pH adjusting agent.This lotion has excellent time stability.The present invention is by obtaining hydroxycitric acid and salicylic acid compounding the lotion that one kind can be stabilized under pH5 ~ 8, overcoming in the prior art, and hydroxycitric acid stability in lotion matrix is poor, the deficiency that easily crystallizes.In addition, pH5 ~ 8 belong to the range of class neutrality, there is preferable tolerance for emulsion materials, increase the mouldability of this lotion.
Description
Technical field
The invention belongs to cosmetics to configure product technical field, and in particular to be a kind of moisture-keeping crease-shedding lotion and its preparation side
Method.
Background technique
Moisturizing refers to the moisturizing of skin.When air themperature reduces, keratoderma cannot adjust enough moisturizings in time
The factor, the decline of grease gland liveness, grease, moisture decline, skin will appear tight phenomenon, even now and nose branch on the face
Existing microgroove.
Contain hydrophilic moisturizer in existing lotion, to moisturize the skin and prevent skin moisture evaporation, improve micro- follow
Ring enhances skin wettability.
When this kind of moisturizer is smeared on the skin, effect is only limitted to infiltration cuticula, and moistening effect is temporary, and
Moisture cannot be lockked, the moisture-retaining capacity of cuticula itself also just can not be fundamentally improved.
The outermost layer of skin is cuticula, and there are also one layer of sebum films outside cuticula.Whether cuticula water shortage or skin
Matter hyposecretion can all cause to have dry skin.So dry skin, may be not merely because cuticula moisture it is inadequate, and
It is " water lock " deficiency.
Therefore, it is necessary to research and develop a moisture-keeping crease-shedding skin care item, the effect for improving cuticula moisture-retaining capacity is made it have.
Summary of the invention
It is an object of the invention to overcome defect and deficiency mentioned above, and provide a kind of moisture-keeping crease-shedding lotion.
Another object of the present invention is to provide the preparation methods of above-mentioned skin care item.
The present invention realizes its purpose, and the technical solutions adopted are as follows.
A kind of moisture-keeping crease-shedding lotion, which is characterized in that the component including following parts by weight:
Hydroxycitric acid, 4 ~ 6 parts;
Salicylic acid, 3 ~ 4 parts;
And pH to 5 ~ 8 is adjusted using pH adjusting agent.
A kind of moisture-keeping crease-shedding lotion, further includes the component of following parts by weight:
Octyl dodecanol myristinate, 0.5 ~ 3 part;
Cremophor RH40,0.5 ~ 3 part;
Thallus laminariae extract, 1 ~ 5 part;
Glycerol, 40 ~ 50 parts;
Acrylic acid (ester) analog copolymer sodium, 2 ~ 4 parts;
PH adjusting agent, 1.5 ~ 3 parts;
Skin conditioning agent, 5 ~ 7.6 parts;
Deionized water, 500 ~ 650 parts.
The pH adjusting agent, including in sodium hydroxide, potassium hydroxide, triethanolamine, aminomethyl propanol, arginine at least
It is a kind of;The parts by weight of the sodium hydroxide are 0 ~ 0.5 part;The parts by weight of the potassium hydroxide are 0 ~ 0.5 part;Three second
The parts by weight of hydramine are 0 ~ 0.25 part;The parts by weight of the aminomethyl propanol are 0.5 ~ 1.5 part;The arginic weight
Number is 0 ~ 0.5 part.
The skin conditioning agent, including double-docosyl alcohol/isooctadecanol/phytosterol dimerization Asia oleyl alcohol dimerized linoleic acid ester,
Plant saualane, Butyrospermum parkii fruit rouge, rice protein active polypeptide;Double-docosyl alcohol/isooctadecanol/phytosterol the dimerization
The parts by weight of sub- oleyl alcohol dimerized linoleic acid ester are 0.25 ~ 0.7 part;The parts by weight of the plant saualane are 0.5 part;It is described
The parts by weight of Butyrospermum parkii fruit rouge are 0.3 ~ 1 part;The parts by weight of the rice protein active polypeptide are 3 ~ 5 parts.
Double-docosyl alcohol/isooctadecanol/phytosterol dimerization Asia oleyl alcohol dimerized linoleic acid ester, natural plants saualane, butter
Fruit tree fruit rouge, rice protein active polypeptide are used in compounding, and have good compatibility with skin, promote skin regeneration, and softening is grown
Profit, nutrition skin, effectively prevent water loss, and help restores skin pliability and elasticity.
The skin conditioning agent further includes cholesterine, olive oil;The cholesteric parts by weight are 0.25 ~ 0.7
Part;The parts by weight of the olive oil are 0.5 ~ 0.8 part.
A kind of method of moisture-keeping crease-shedding lotion, which comprises the following steps:
(1), deionized water is added in water phase pot, Cremophor RH40 is added, stirred to after being completely dissolved, propylene is added
Sour (ester) analog copolymer sodium, stirs evenly, then sequentially adds glycerol, thallus laminariae extract, stir evenly and be warming up to 60 DEG C ~
75 DEG C, frost shape gel rubber system is made;
(2), skin conditioning agent, octyl dodecanol myristinate are added in oily phase pot, are added to 75 DEG C ~ 80 DEG C, stirring
Uniformly, oily mutually material is obtained;
(3), water phase material is pumped into emulsion pot, stirs and is successively pumped into oil mutually material, pH adjusting agent, salicylic acid, hydroxyl lemon under homogeneous
Lemon acid, stirs evenly at 75 DEG C ~ 80 DEG C and keeps the temperature 15 ~ 20 minutes, forms the moisture-keeping crease-shedding lotion of oil-in-water emulsified system.
Technical solution provided by the invention can reach following technical effect:
(1) excellent time stability.The present invention by by hydroxycitric acid and salicylic acid compounding, obtain one kind can pH5 ~
The lotion being stabilized under 8 overcomes in the prior art, and stability is poor in the base for hydroxycitric acid, the deficiency that easily crystallizes.Separately
Outside, pH5 ~ 8 belong to the range of class neutrality, have preferable tolerance for emulsion materials, increase the mouldability of this lotion,
It is also low to the irritation of skin.
(2) use feeling is pure and fresh, non-greasy.
(3) moisture-retaining capacity is good.Hydroxycitric acid as natural plant extracts, to skin there is maintenance to releive, moisturizing,
Increase the effect of skin elasticity.
(4) it does not stimulate mildly, formula scientific and precise, effect definitely have no toxic side effect.
(5) anti-wrinkle effect is obvious, has the function of preferably improving dermatoglyph.
Specific embodiment
Invention is further described in detail below.
A kind of moisture-keeping crease-shedding lotion, is composed of the following parts by weight:
Hydroxycitric acid, 4 ~ 6 parts;
Salicylic acid, 3 ~ 4 parts;
Octyl dodecanol myristinate, 0.5 ~ 3 part;
Cremophor RH40,0.5 ~ 3 part;
Thallus laminariae extract, 1 ~ 5 part
Glycerol, 40 ~ 50 parts;
Acrylic acid (ester) analog copolymer sodium, 2 ~ 4 parts;
PH adjusting agent, 1.5 ~ 3 parts;
Skin conditioning agent, 5 ~ 7.6 parts;
Deionized water, 500 ~ 650 parts.
Hydroxycitric acid (hydroxy citric Acid, HCA), mainly proposes from the fruit of gamboge platymiscium
A kind of natural organic acids arrived.
Hydroxycitric acid, as a kind of natural plant product, with very long edible and medicinal history, since it is to lemon
The affinity of acid cleavage enzyme is more much higher than natural substrate (citric acid), so can preferentially combine with enzyme, so that citric acid be inhibited to split
The activity for solving enzyme reduces intracorporal Adipogenesis, therefore HCA has good effects in terms of weight-reducing, reduction, is used as
Natural diet food major function composition.(referring to: Yuan Erdong, progress [J] of efficacy active component monohydroxy citric acid
Sichuan food and fermentation, 2006,42 (2): 19-23.)
The chemical structural formula of hydroxycitric acid is as follows:
Known hydroxycitric acid, which has, inhibits Adipogenesis.But hydroxycitric acid is poor in the dissolubility of lotion basis material, crystallization.
The present invention is by obtaining hydroxycitric acid and salicylic acid compounding the lotion that one kind can be stabilized under pH5 ~ 8, overcoming
In the prior art, stability is poor in the base, the deficiency that easily crystallizes for hydroxycitric acid.
In addition, hydroxycitric acid as natural plant extracts, in this lotion, as emollient, can be retained in
Skin surface improves Stratum corneum lipids content, prevents skin degreasing, drying, meanwhile, there is greasy property, and skin can be increased
The flexibility of skin, good permeability, using skin has salubrious smooth feeling.
Hydroxycitric acid: using the HCA of one hundred Nian Shidan moral detection technique Co., Ltd of Shanghai, purity 98.70%.
Salicylic acid has certain exfoliating, antibacterial, anti-inflammatory effect.
Octyl dodecanol myristinate (Octyldodecyl Myristate) is moisturizing grease, skin can be made submissive,
Skin-friendly is very good.
Essence, the oily matters such as essential oil can be evenly dispersed into water by Cremophor RH40, formed and stablized, thoroughly
Bright solution has emulsification to the other components of skin care item, and molecular structure had not only had hydrophilic radical but also had hydrophobic grouping,
It enables to oil substances to become tiny kenel, uses more comfortable, ventilative.In addition, it can also reduce skin barrier work
With effective active object is easy key entry skin inner layer and plays a role.
Thallus laminariae extract (Phytessence Wakame), the water-soluble essence from opotism algae have the tender of preciousness
Skin effect.Thallus laminariae extract, can be using the model NAT-214's of Hunan Lang Lin living resources limited liability company production
Thallus laminariae extract.
Glycerol belongs to small molecule moisturizing ingredient, have good moistening effect, moisture can be retained in cuticula, by from
Moisture is absorbed in air to help skin water lock.
Acrylic acid (ester) analog copolymer sodium, i.e. propenyl benzene/acrylic acid (ester) analog copolymer sodium (NSKIN NG) have steady
The performances such as fixed, thickening, moisturizing, dispersion can be used in cream, lotion and foundation cream;With stable emulsion body, coating resistance two is reduced
It tends to smear out.Skin is provided similar to the sliding feeling for being full of profit of hyaluronic acid silk, and forms thin film in skin surface, slows down moisture
Evaporation.Acrylic acid (ester) the analog copolymer sodium of the present invention using the production of EOC company, Belgium, model Europacif
2150。
PH adjusting agent, including at least one in sodium hydroxide, potassium hydroxide, triethanolamine, aminomethyl propanol, arginine
Kind.
Preferably, the parts by weight of the sodium hydroxide are 0 ~ 0.5 part;The parts by weight of the potassium hydroxide be 0 ~
0.5 part;The parts by weight of the triethanolamine are 0 ~ 0.25 part;The parts by weight of the aminomethyl propanol are 0.5 ~ 1.5 part;Institute
Stating arginic parts by weight is 0 ~ 0.5 part.This lotion adjusts pH using pH adjusting agent and ties up to 5 ~ 8, and at the pH of the neutrality
Keep steady fixed state.
Skin conditioning agent improves skin moisturizing and phylactic power defensive power.It is that double-docosyl alcohol/isooctadecanol/phytosterol dimerization is sub-
Oleyl alcohol dimerized linoleic acid ester, plant saualane, Butyrospermum parkii fruit rouge, rice protein active polypeptide, cholesterine, olive oil
Concentrate is mixed, the structure of similar keratoderma sebum film plays the strong skin barrier function of cooperative effect, helps improve flesh
Skin is sensitive.
The skin conditioning agent by double-docosyl alcohol/isooctadecanol/phytosterol dimerization Asia oleyl alcohol dimerized linoleic acid ester, is planted
Object saualane, Butyrospermum parkii fruit rouge, rice protein active polypeptide, cholesterine, olive oil composition.
Double-docosyl alcohol/isooctadecanol/phytosterol dimerization Asia oleyl alcohol dimerized linoleic acid ester parts by weight are 0.25
~ 0.7 part;The parts by weight of the plant saualane are 0.5 part;The parts by weight of the Butyrospermum parkii fruit rouge are 0.3 ~ 1 part;Institute
The parts by weight for stating rice protein active polypeptide are 3 ~ 5 parts;The cholesteric parts by weight are 0.25 ~ 0.7 part;The oil olive
The parts by weight of olive fruit oil are 0.5 ~ 0.8 part.
Double-docosyl alcohol/isooctadecanol/phytosterol dimerization Asia oleyl alcohol dimerized linoleic acid ester is that dimerization Asia oleyl alcohol dimerization is sub-
Product after oleate docosyl alcohol, isooctadecanol, phytosterol mixed alcohol sealing end, can moisturize the skin, prevent skin surface water
The evaporation divided has good moistening effect.Phytosterin ester have with structure as human skin steroid, be that tissue is thin
The important component of born of the same parents plays good barrier action to skin, can protect skin and be not affected by.Phytosterol
Ester can form liquid crystal structure, have very high permeability to skin, increase skin elasticity, it is possible to reduce pachylosis, it can be with
Skin surface moisture is kept, scytitis is inhibited, promotes wound healing, anti-sun erythema, skin aging, chap etc..
Plant saualane derives from olive oil, is a kind of natural soothing oil, close to a kind of lipid of human sebaceous, parent
It is strong with power, it can combine together with the sebum film of mankind itself, form one layer of natural barrier in skin surface, moreover it is possible to inhibit skin
The peroxidating of skin lipid can effectively penetrate into skin, and promote the proliferation of skin base cell, to delay skin aging, improve simultaneously
Eliminating chloasma has apparent physiologic effect.
Rice protein active polypeptide is biologically active peptide and natural carbohydrate mixture.By protecting and repairing
DNA enhances cell viability, extends cell survival;Inducing collagen is newborn, and protects it from being degraded, to enhance cell
Epimatrix achievees the effect that desalinate wrinkle, prevention skin early ageing.
Preferably, in the present solution, rice protein active polypeptide, can use in Publication No. CN103045707A
State's patent preparation method.
Enumerating for the citing of concrete component model in the technical program, only the component one of which application, is not limited
It is fixed.
Butyrospermum parkii fruit rouge is rich in unsaturated fatty acid, can reinforce the moisture-retaining capacity of skin, impaired to stemness and cutin
Skin can be moistened.
Cholesterine can form liquid crystal structure, have very high permeability to skin, increase skin elasticity, it is possible to reduce skin
Skin is coarse, can keep skin surface moisture, inhibits scytitis, promotes wound healing, anti-sun erythema, skin aging, chap
It splits.
Olive oil is rich in unsaturated fatty acid and various vitamins, is easily absorbed by the skin, has containing Polyphenols anti-
The effect of oxidation.Color spot and wrinkle brought by the cell senescence occurred due to fat is oxidized can be effectively avoided in it.
The embodiment of the present application is right by by properly mixed hydroxycitric acid, salicylic acid, pH adjusting agent and skin conditioning agent
Skin has preferable moisturizing, moist, crease-resistant and other effects.
The embodiment of the present invention dosage is following (parts by weight):
The preparation method of above-mentioned moisture-keeping crease-shedding lotion, comprising the following steps: (1), deionized water is added in water phase pot, is added
Cremophor RH40 is stirred to after being completely dissolved, and acrylic acid (ester) analog copolymer sodium is added, stirs evenly, then successively
Glycerol, thallus laminariae extract is added, stir evenly and is warming up to 60 DEG C ~ 75 DEG C, obtained frost shape gel rubber system;
(2), skin conditioning agent, octyl dodecanol myristinate are added in oily phase pot, are added to 75 DEG C ~ 80 DEG C, stirring
Uniformly, oily mutually material is obtained;
(3), water phase material is pumped into emulsion pot, stirs and is successively pumped into oil mutually material, pH adjusting agent, salicylic acid, hydroxyl lemon under homogeneous
Lemon acid, stirs evenly at 75 DEG C ~ 80 DEG C and keeps the temperature 15 ~ 20 minutes, forms the moisture-keeping crease-shedding lotion of oil-in-water emulsified system.
, sense organ obvious according to finished product effect obtained by embodiment of the present invention is good, pH value and consistency are moderate, quality is steady
Fixed, the indices of embodiment 5 are best, are best mode for carrying out the invention.
One, physical and chemical index pH test
PH test is carried out to embodiment 1-5, reference examples 1-2, test result see the table below:
Experiment discusses: the pH value range of embodiment 1-5 sample and reference examples 1-2 are in the close neutrality of 6.20 or so, PH, more temperature
With.
Two, moisture-keeping efficacy evaluation
Experimental method:
Subject amounts to 60 people, and specific sex composition and age composition determine at random, and within test period, recipient site is not found
Adverse reaction.
1. the selection left and right arm of 30 subjects circuits sequentially label: tested region embodiment group (any embodiment of the present invention
Skin care item obtained) and blank control region;
The remaining left and right arm of 30 subjects is selected to circuit sequentially label: tested region reference examples group (any reference examples system of the present invention
The skin care item obtained) and blank control region.
2. technical staff is scattered and disappeared through skin and is tested using moisture content of skin test Corneometer CM825, moisture
Tewameter TM300 measures tested region and blank control region respectively, is averaged, and is denoted as initial value.
3. smearing submitted sample in the Test sites that subject cleaned through clear water, any sample is not smeared in blank control region
Product.
4. subject uses moisture content of skin after continuous use lotion one hour, two hours, four hours, by technical staff
Test Corneometer CM825, moisture measure tested region and blank through the lost test Tewameter TM300 of skin respectively
It control zone 5 times, is averaged.
5. counting the numerical value measured, its moisture of skin and moisture loss changing rule are analyzed.
Interpretation of result:
Moisture content change was reflected in test period, and Experimental Area moisture content changes over time rule.Its value is bigger, moisture
Content is bigger, conversely, moisture content is smaller.Water content difference (Δ T)=use each time point water content (T after producth)-make
With water content (T before product0).
The difference of embodiment group, the moisture content of reference examples group and blank example group and initial value
Relative to reference examples group and blank example group, the moisture content of embodiment group is obviously higher, the moisture content of embodiment group
Higher level is maintained, moistening effect is obvious.
Three, crease-resistant efficacy assessments
Experimental method:
Subject amounts to 64 people.Specific sex composition determines at random.If period there are 2 people adverse reaction occur, test is terminated;Knot
Fruit does not find adverse reaction.After subject has smeared skin care item made from any embodiment of the present invention, the roughness of skin has
It is obviously improved.
1. selecting 32 left and right corners of the mouths of subject as tested region.The left corners of the mouth of every subject smears given the test agent (this hair
Skin care item made from bright any embodiment) it is used as embodiment group, the right corners of the mouth does not smear any sample as blank control group.
Select remaining 32 left and right corners of the mouths of subject as tested region.The left corners of the mouth of every subject smears given the test agent (this
Invent skin care item made from any reference examples) as reference examples group, the right corners of the mouth does not smear any sample as blank control group.
2. being tested by technical staff using II Multi-functional skin mirror image analysis system of MicroSkin and moisture content of skin
Smear the dermatoglyph degree before lotion in instrument measurement experiment position.
3. testing product is smeared in the tested area (the same area) cleaned by clear water sooner or later daily, during experiment, by
Examination person cannot apply the other any lotions erased outside tested sample in Test sites.
4. subject is after being used continuously lotion one week, two weeks, three weeks and four weeks, same time subject will be smeared weekly
Position is cleaned, and uses II Multi-functional skin mirror image analysis system of MicroSkin and moisture content of skin tester by tester
Measure spreader portion bit value.
5. the numerical value that statistics subject position measures every time, the variation rule of analyzing skin texture and moisture content
Rule.
Experimental result:
The dermatoglyph of embodiment group, reference examples group and blank example group measures average value
Within 4 weeks test periods, after recipient site uses experimental group sample, skin roughness is in decreasing trend always.Sample
After 4 weeks, the change rate of skin roughness is -6.50%, and there are significant difference (p < 0.05) for opposite initial value.
Four, lotion human body patch test
Experimentation: subject amounts to 30 people, and determination (meets " cosmetics contact at random for specific sex composition and age composition
Dermatitis diagnostic criteria and treatment principle " be included in, exclusion criteria).
Qualified patch material is selected, (amount of samples will be put into spot tester according to sample made from any embodiment of the present invention
For 0.020 ~ 0.025g), control wells are blank (not setting any substance).Sample and blank control are affixed on to the forearm of subject
Bent side is gently pressed with palm and is allowed to equably be pasted on skin, continued for 24 hours.It is spaced 30min after removal patch device, is disappeared to impression
Dermoreaction is observed after mistake.Observe primary, observation dermoreaction after patch test again respectively with 48h for 24 hours.
Criterion:
Classified according to " cosmetics contact dermatitis diagnostic criteria and treatment principle " and determined: reactionless recipient site is (0), skin
Light red spot occur is (1), and it is (2) that erythema, infiltration or papule, which occurs, in skin, and edematous erythema occurs in skin, papule is (3), skin
There is significant red and swollen, companion's papule in skin or bleb is (4).
The number for occurring 2 grades of skin adverse reactions in 30 is more than 2, or any 13 grades or 3 grades or more skins occurs
When adverse reaction, determine that tested material has adverse reaction to human body.
Concrete outcome evaluation is as shown in the table:
Remove 0.5 hour observation result of spot tester
Remove 24 hours observation results of spot tester
Remove 48 hours observation results of spot tester
The results showed that this time sample patch test results are sentenced according to the requirement of 2007 " cosmetics health specifications " in experiment
The fixed crease-resistant skin care item of eye of the invention have no adverse reaction to human skin.
Five, stability test
By embodiment 1 ~ 5 and reference examples 1 ~ 2, the insulating box in 5 DEG C and 45 DEG C, after three months, observes skin care item in appearance respectively
Variation.
Zero: indicating that variation is not observed in appearance.
×: crystal settling or aggregation are observed in expression.
Six, viscosity test
By women panel of expert (20 people), embodiment 1 ~ 5 and reference examples 1 ~ 2 are carried out using test, and according to following standard
Have evaluated non-stick property amount.
000: thinking that they do not think sticky paste more than 18 people.
00: 14 to 17 people think that they are imperceptible sticky.
Zero trade fair: 9 to 13 people think that they are imperceptible sticky.
×: judge that the composition does not have the number of sticky sense for 8 or less.
The present invention is illustrated according to embodiment, under the premise of not departing from present principles, if the present apparatus can also make
Dry modification and improvement.It should be pointed out that it is all using modes technical solutions obtained such as equivalent substitution or equivalent transformations, all fall within this
In the protection scope of invention.
Claims (6)
1. a kind of moisture-keeping crease-shedding lotion, which is characterized in that the component including following parts by weight:
Hydroxycitric acid, 4 ~ 6 parts;
Salicylic acid, 3 ~ 4 parts;
And pH to 5 ~ 8 is adjusted using pH adjusting agent.
2. a kind of moisture-keeping crease-shedding lotion as described in claim 1, which is characterized in that further include the component of following parts by weight:
Octyl dodecanol myristinate, 0.5 ~ 3 part;
Cremophor RH40,0.5 ~ 3 part;
Thallus laminariae extract, 1 ~ 5 part;
Glycerol, 40 ~ 50 parts;
Acrylic acid (ester) analog copolymer sodium, 2 ~ 4 parts;
PH adjusting agent, 1.5 ~ 3 parts;
Skin conditioning agent, 5 ~ 7.6 parts;
Deionized water, 500 ~ 650 parts.
3. a kind of moisture-keeping crease-shedding lotion as claimed in claim 2, which is characterized in that the pH adjusting agent, including sodium hydroxide,
At least one of potassium hydroxide, triethanolamine, aminomethyl propanol, arginine;The parts by weight of the sodium hydroxide are 0 ~ 0.5
Part;The parts by weight of the potassium hydroxide are 0 ~ 0.5 part;The parts by weight of the triethanolamine are 0 ~ 0.25 part;The ammonia first
The parts by weight of base propyl alcohol are 0.5 ~ 1.5 part;The arginic parts by weight are 0 ~ 0.5 part.
4. a kind of moisture-keeping crease-shedding lotion as claimed in claim 2 or claim 3, which is characterized in that the skin conditioning agent, including double-
Docosyl alcohol/isooctadecanol/phytosterol dimerization Asia oleyl alcohol dimerized linoleic acid ester, plant saualane, Butyrospermum parkii fruit rouge, rice egg
White active peptides;Described double-docosyl alcohol/isooctadecanol/phytosterol dimerization Asia oleyl alcohol dimerized linoleic acid ester parts by weight are
0.25 ~ 0.7 part;The parts by weight of the plant saualane are 0.5 part;The parts by weight of the Butyrospermum parkii fruit rouge are 0.3 ~ 1
Part;The parts by weight of the rice protein active polypeptide are 3 ~ 5 parts.
5. a kind of moisture-keeping crease-shedding lotion as claimed in claim 4, which is characterized in that the skin conditioning agent further includes cholesteric
Alcohol, olive oil;The cholesteric parts by weight are 0.25 ~ 0.7 part;The parts by weight of the olive oil be 0.5 ~
0.8 part.
6. preparing a kind of method of moisture-keeping crease-shedding lotion as claimed in claim 5, which comprises the following steps:
(1), deionized water is added in water phase pot, Cremophor RH40 is added, stirred to after being completely dissolved, propylene is added
Sour (ester) analog copolymer sodium, stirs evenly, then sequentially adds glycerol, thallus laminariae extract, stir evenly and be warming up to 60 DEG C ~
75 DEG C, frost shape gel rubber system is made;
(2), skin conditioning agent, octyl dodecanol myristinate are added in oily phase pot, are added to 75 DEG C ~ 80 DEG C, stirring
Uniformly, oily mutually material is obtained;
(3), water phase material is pumped into emulsion pot, stirs and is successively pumped into oil mutually material, pH adjusting agent, salicylic acid, hydroxyl lemon under homogeneous
Lemon acid, stirs evenly at 75 DEG C ~ 80 DEG C and keeps the temperature 15 ~ 20 minutes, forms the moisture-keeping crease-shedding lotion of oil-in-water emulsified system.
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CN114177270A (en) * | 2020-09-14 | 2022-03-15 | 美黛(上海)生物科技有限公司 | Composition for treating acne and preparation method thereof |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006033476A1 (en) * | 2004-09-24 | 2006-03-30 | Showa Denko K.K. | Hydroxycitric acid derivatives and skin external preparations containing the same |
CN101193629A (en) * | 2005-03-24 | 2008-06-04 | 位相转换有限公司 | A topical composition and its uses |
US20100331412A1 (en) * | 2009-03-30 | 2010-12-30 | Patricia Lawler Kenet | Two container skin care product |
CN108567641A (en) * | 2018-07-07 | 2018-09-25 | 佛山市芊茹化妆品有限公司 | The tender factor of vegetation water and the skin care compositions for including the tender factor of vegetation water |
CN108653142A (en) * | 2018-07-01 | 2018-10-16 | 佛山文森特知识产权服务有限公司 | A kind of moisture-keeping composition |
-
2019
- 2019-07-08 CN CN201910611059.7A patent/CN110141526B/en active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006033476A1 (en) * | 2004-09-24 | 2006-03-30 | Showa Denko K.K. | Hydroxycitric acid derivatives and skin external preparations containing the same |
CN101193629A (en) * | 2005-03-24 | 2008-06-04 | 位相转换有限公司 | A topical composition and its uses |
US20100331412A1 (en) * | 2009-03-30 | 2010-12-30 | Patricia Lawler Kenet | Two container skin care product |
CN108653142A (en) * | 2018-07-01 | 2018-10-16 | 佛山文森特知识产权服务有限公司 | A kind of moisture-keeping composition |
CN108567641A (en) * | 2018-07-07 | 2018-09-25 | 佛山市芊茹化妆品有限公司 | The tender factor of vegetation water and the skin care compositions for including the tender factor of vegetation water |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114177270A (en) * | 2020-09-14 | 2022-03-15 | 美黛(上海)生物科技有限公司 | Composition for treating acne and preparation method thereof |
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