CN110042055B - Operating table for cell ultrasound - Google Patents

Operating table for cell ultrasound Download PDF

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Publication number
CN110042055B
CN110042055B CN201910356743.5A CN201910356743A CN110042055B CN 110042055 B CN110042055 B CN 110042055B CN 201910356743 A CN201910356743 A CN 201910356743A CN 110042055 B CN110042055 B CN 110042055B
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bottom plate
frame
base
fixed
ultrasonic
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CN110042055A (en
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路军秀
朱茉莉
郭超
祝田田
薛金涛
李鹏
房志鑫
李伟
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Xinxiang Medical University
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Xinxiang Medical University
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/04—Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • General Engineering & Computer Science (AREA)
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  • Microbiology (AREA)
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  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Mechanical Engineering (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
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Abstract

The invention relates to an operating console for cell ultrasound, which effectively solves the problem that the cell activity is influenced when the cell ultrasound is carried out by the existing instrument; the technical scheme who its solution includes the base, it has a transparent box to peg graft on the base, the base constitutes an airtight cavity with the box, the base top is equipped with a bottom plate, the left side of bottom plate articulates on the base, the right side articulates there is one to drive the bottom plate around the wobbling electric putter of right side handing-over position, the upper end of bottom plate is fixed with a stand, the upper end demountable installation of stand has a first frame parallel with the bottom plate, sliding connection has the loading board that can control about in the first frame, the below of loading board is equipped with ultrasonic probe, the outside of airtight cavity is equipped with ultrasonic generator, ultrasonic generator is connected with ultrasonic probe through waveguide transmission line.

Description

Operating table for cell ultrasound
Technical Field
The invention relates to the field of cell ultrasonic equipment, in particular to an operating table for cell ultrasonic.
Background
The diagnosis-grade low-intensity ultrasound combined microbubble contrast agent can provide a novel method which is noninvasive, effective and convenient for the treatment of some diseases of organisms, has very important clinical and social meanings, low-intensity ultrasound (the sound energy intensity is less than or equal to 3W/cm 2) is different from high-intensity ultrasound and low-frequency ultrasound, mainly plays a role through a cavitation effect, and can reduce the energy threshold required by the cavitation effect generated by the ultrasound by using ultrasound microbubbles as cavitation nuclei to enhance the cavitation effect, so that the combination of the low-intensity ultrasound and the high-intensity ultrasound can better promote the treatment effect, has the advantages of safety, repeatability, wide application range and the like, needs to perform some experiments on cells in order to better research the influence and mechanism of the diagnosis-grade low-intensity ultrasound combined microbubble contrast agent on human bodies, needs to have a table capable of fixing an ultrasound probe and placing a cell culture plate, and is performed at room temperature when the existing instrument performs cell ultrasound, however, the cell growth environment is 37 ℃, because the experiment operation time is long, the cell is in the environment lower than 37 ℃ for a long time, the cell activity is inevitably influenced, and the accuracy of the experiment result is influenced, so that a constant-temperature cell ultrasonic operation platform is designed to solve the problem.
Disclosure of Invention
Aiming at the situation, in order to overcome the defects of the prior art, the invention provides the operating table for cell ultrasound, which effectively solves the problem that the cell activity is influenced when the existing instrument is used for cell ultrasound.
The technical scheme of its solution problem includes the base, it has a transparent box to peg graft on the base, the base constitutes an airtight cavity with the box, the base top is equipped with a bottom plate, the left side of bottom plate articulates on the base, the right side articulates there is one and can drive the bottom plate around the wobbling electric putter of right side articulated position, the upper end of bottom plate is fixed with a stand, the upper end demountable installation of stand has a first frame parallel with the bottom plate, sliding connection has the loading board that can control about in the first frame, the below of loading board is equipped with ultrasonic probe, the outside of airtight cavity is equipped with ultrasonic generator, ultrasonic generator is connected with ultrasonic probe through waveguide transmission line.
The cell exciting device is novel in concept, ingenious in structure and high in practicability, cells are excited under the action of the ultrasonic probe in different areas of the bearing plate controlled by the console in the constant-temperature cavity, and meanwhile, the electric push rod swings the bottom plate to realize cell shaking, so that the cell exciting device is more reasonable and efficient in the cell exciting process, and the problem that the cell activity is influenced when cells are subjected to ultrasonic treatment by the conventional device is effectively solved.
Drawings
FIG. 1 is a three-dimensional view of the present invention without the ultrasound generating device and console and without the housing installed.
FIG. 2 is a three-dimensional view of the present invention without the console and with the cabinet installed.
Fig. 3 is a three-dimensional view of the present invention.
Detailed Description
The following describes embodiments of the present invention in further detail with reference to the accompanying drawings.
As can be seen from fig. 1 to 3, the ultrasonic diagnosis device comprises a base 1, a transparent box body 2 is inserted into the base 1, the base 1 and the box body 2 form a closed cavity, a bottom plate 3 is arranged above the base 1, the left side of the bottom plate 3 is hinged to the base 1, the right side of the bottom plate 3 is hinged to an electric push rod 4 capable of driving the bottom plate 3 to swing around the hinged position on the right side, an upright post 5 is fixed at the upper end of the bottom plate 3, a first frame 6 parallel to the bottom plate 3 is detachably mounted at the upper end of the upright post 5, a bearing plate 7 capable of moving left and right is slidably connected in the first frame 6, an ultrasonic probe 8 is arranged below the bearing plate 7, an ultrasonic generating device 9 is arranged on the outer side of the closed cavity, and the ultrasonic generating device 9 is connected with the ultrasonic probe 8 through a waveguide transmission line 10.
In order to realize that the bottom plate 3 can swing around the right hinged position, the front side and the rear side of the bottom plate 3 are respectively provided with a first hinged lug 11 fixed on the base 1, the right end of the bottom plate 3 is hinged with the first hinged lug 11 through a hinged shaft, the front side and the rear side of the bottom plate 3 are also provided with second hinged lugs 12, the bottom of the electric push rod 4 is hinged on the second hinged lugs 12, and the extending end of the electric push rod 4 is hinged with the left side of the bottom plate 3.
In order to fix the ultrasonic probe 8, a second frame 13 is arranged below the first frame 6, one end of the second frame 13 is fixed on the upright post 5 through a clamping screw, a V-shaped chuck 14 is slidably mounted on the second frame 13, the V-shaped chuck 14 is composed of two half blocks, one half block is fixedly connected with the second frame 13 through a clamping groove and a set screw, the other half block fixes the ultrasonic probe 8 on the V-shaped chuck 14 through a screw, and the V-shaped chuck 14 can be adjusted to different positions on the second frame 13 of the supporting plate.
In order to realize that the bearing plate 7 can move left and right on the first frame 6, a sliding groove 15 is arranged on the first frame 6, a fixed frame 16 is arranged in the sliding groove 15, the bearing plate 7 is fixedly pressed on the fixed frame 16 through a pressing strip and a screw, the fixed frame 16 is fixedly connected with a sliding block of a linear motion component 17 driven by a motor through a bayonet groove, and the linear motion component 17 is fixed on the first frame 6.
In order to ensure the tightness between the waveguide transmission line 10 and the box body 2, a sealing ring is arranged between the waveguide transmission line 10 and the transparent box body 2, the sealing ring is two semi-rings, one semi-ring sealing ring is fixed on the base 1, the other semi-ring sealing ring is fixed at the lower end of the box body 2, and the two semi-rings are buckled to seal the transmission line and the box body 2.
In order to facilitate the operation, a control console 18 is further arranged on the outer side of the closed cavity, and a display screen is arranged on the control console 18 and is provided with a control switch of the electric push rod 4, a driving switch of the motor and a control switch of the ultrasonic generating device 9.
The specific working process of the invention is as follows: the control switch of the ultrasonic generating device 9 on the control console 18 can control the ultrasonic generating device 9 to enable the ultrasonic probe 8 to send ultrasonic waves through the waveguide transmission line 10, the base 1 and the box body 2 form a closed cavity, the cavity can provide a constant-temperature and constant-humidity working environment for cells through the temperature control device, the temperature and the humidity can be adjusted and set at will, and a sterile clean space is formed, and meanwhile, the base 1 and the box body 2 are separated conveniently and are in an insertion connection mode.
The device realizes the positive and negative rotation of the motor through the motor drive switch arranged on the control console 18, the rotation of the motor can drive the linear motion assembly 17, the linear motion assembly 17 can be an electric pull rod or a slider-crank mechanism, the pressing strip and the screw are fixedly pressed on the fixing frame 16 through the linear drive assembly, the bearing plate 7 moves left and right to realize that different positions of the externally controllable bearing plate 7 can be close to the ultrasonic probe 8 below and can realize that the ultrasonic probe 8 acts on each position of the bearing plate 7, the bearing plate 7 moves along the length direction of the bearing plate in the device, the acting range of the ultrasonic probe 8 is a width range of the bearing plate 7, therefore, the bearing plate 7 moves left and right to realize that the ultrasonic probe 8 acts on each position of the bearing plate 7, and therefore, the cellular region on the bearing plate 7 is activated.
The electric push rod 4 is controlled to extend and retract through a driving switch of the electric push rod 4 on the control console 18, and the bottom plate 3 can rotate around a hinge shaft hinged on the first hinge lug 11 at the right end of the bottom plate 3 when the electric push rod 4 extends and retracts, so that the bottom plate 3 swings, and cells can keep moving in the experimental process.
The cell exciting device is novel in concept, ingenious in structure and high in practicability, cells are excited under the action of the ultrasonic probe in a constant-temperature cavity through the control of the control console in different areas, and meanwhile, the electric push rod swings the bottom plate to realize cell shaking, so that the cell exciting device is more reasonable and efficient in the cell exciting process, and the problem that the cell activity is influenced when cells are subjected to ultrasonic treatment in the conventional device is effectively solved.

Claims (3)

1. An operation table for cell ultrasound comprises a base (1) and is characterized in that, the ultrasonic testing device is characterized in that a transparent box body (2) is inserted into the base (1), the base (1) and the box body (2) form a closed cavity, a bottom plate (3) is arranged above the base (1), the left side of the bottom plate (3) is hinged to the base (1), the right side of the bottom plate is hinged to an electric push rod (4) capable of driving the bottom plate (3) to swing around a right-side hinged position, an upright post (5) is fixed to the upper end of the bottom plate (3), a first frame (6) parallel to the bottom plate (3) is detachably mounted at the upper end of the upright post (5), a bearing plate (7) capable of moving left and right is connected in the first frame (6) in a sliding mode, an ultrasonic probe (8) is arranged below the bearing plate (7), an ultrasonic generating device (9) is arranged on the outer side of the closed cavity, and the ultrasonic generating device (9) is connected with the ultrasonic probe (8) through a waveguide transmission line (10);
a second frame (13) with one end fixed on the upright post (5) through a clamping screw is arranged below the first frame (6), a V-shaped chuck (14) is installed on the second frame (13) in a sliding mode, the V-shaped chuck (14) is composed of two half blocks, one half block is fixedly connected with the second frame (13) through a clamping groove and a set screw, the other half block fixes the ultrasonic probe (8) on the V-shaped chuck (14) through a screw, and the V-shaped chuck (14) can be adjusted to different positions on the second frame (13) of the supporting plate;
the first frame (6) is provided with a sliding chute (15), a fixed frame (16) is installed in the sliding chute (15), the bearing plate (7) is fixedly pressed on the fixed frame (16) through a pressing strip and a screw, the fixed frame (16) is fixedly connected with a sliding block of a linear motion assembly (17) driven by a motor through a bayonet groove, and the linear motion assembly (17) is fixed on the first frame (6);
the outer side of the closed cavity is also provided with a control console (18), the control console (18) is provided with a display screen and is provided with a control switch of the electric push rod (4), a drive switch of the motor and a control switch of the ultrasonic generating device (9);
base (1) and box (2) constitute a airtight cavity, and this cavity passes through temperature control device can realize providing a constant temperature, the operational environment of constant humidity for the cell, and temperature, humidity can need adjust the settlement wantonly to and aseptic clean space, and the convenient separation of base (1) and box (2) of while, and the two adopts to insert the knot mode.
2. The operating table for cell ultrasound according to claim 1, wherein the front side and the rear side of the bottom plate (3) are respectively provided with a first hinge lug (11) fixed on the base (1), the right end of the bottom plate (3) is hinged with the first hinge lug (11) through a hinge shaft, the front side and the rear side of the bottom plate (3) are also provided with second hinge lugs (12), the bottom of the electric push rod (4) is hinged on the second hinge lugs (12), and the extending end of the electric push rod (4) is hinged with the left side of the bottom plate (3).
3. The operation table for cell ultrasonic as claimed in claim 1, wherein a sealing ring is installed between the waveguide transmission line (10) and the transparent case (2), the sealing ring is two semi-rings, one semi-ring sealing ring is fixed on the base (1), the other semi-ring sealing ring is fixed at the lower end of the case (2), and the two semi-rings are buckled to seal the transmission line and the case (2).
CN201910356743.5A 2019-04-29 2019-04-29 Operating table for cell ultrasound Active CN110042055B (en)

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Application Number Priority Date Filing Date Title
CN201910356743.5A CN110042055B (en) 2019-04-29 2019-04-29 Operating table for cell ultrasound

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Application Number Priority Date Filing Date Title
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CN110042055B true CN110042055B (en) 2022-05-13

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Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004041314A1 (en) * 2002-11-04 2004-05-21 Ashland Inc. Device and process for treating a liquid medium using ultrasound in preventing the growth of hyperproliferative or infected cells
CN102994383A (en) * 2012-11-13 2013-03-27 陕西师范大学 Isolated cell marking device and method through magnetic-acoustic combined action
CN104774833A (en) * 2015-02-25 2015-07-15 江苏省中医院 Method for changing ultrastructure of cell by using focused ultrasound
WO2015195212A1 (en) * 2014-06-16 2015-12-23 Sonify Biosciences, Llc System and methods for applying controlled low-intensity ultrasound to a cell culture
CN106726343A (en) * 2016-12-13 2017-05-31 郑州飞龙医疗设备有限公司 Spine correcting bed
CN107165027A (en) * 2017-04-25 2017-09-15 杜海燕 A kind of town road repairing road roller
CN206858587U (en) * 2017-04-07 2018-01-09 安徽九川生物科技有限公司 A kind of dog interferon preparation biomixer
CN107828652A (en) * 2017-10-13 2018-03-23 江苏大学 The cytoactive adjusting method and device of Cell-oriented Activity determination experiment
CN108744322A (en) * 2018-07-09 2018-11-06 北京万孛力医疗器械有限公司 Azoospermia therapeutic equipment

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010053384A1 (en) * 1997-07-07 2001-12-20 James F. Greenleaf Site-directed transfection with ultrasound and cavitation nuclei
US7967763B2 (en) * 2005-09-07 2011-06-28 Cabochon Aesthetics, Inc. Method for treating subcutaneous tissues

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004041314A1 (en) * 2002-11-04 2004-05-21 Ashland Inc. Device and process for treating a liquid medium using ultrasound in preventing the growth of hyperproliferative or infected cells
CN102994383A (en) * 2012-11-13 2013-03-27 陕西师范大学 Isolated cell marking device and method through magnetic-acoustic combined action
WO2015195212A1 (en) * 2014-06-16 2015-12-23 Sonify Biosciences, Llc System and methods for applying controlled low-intensity ultrasound to a cell culture
CN104774833A (en) * 2015-02-25 2015-07-15 江苏省中医院 Method for changing ultrastructure of cell by using focused ultrasound
CN106726343A (en) * 2016-12-13 2017-05-31 郑州飞龙医疗设备有限公司 Spine correcting bed
CN206858587U (en) * 2017-04-07 2018-01-09 安徽九川生物科技有限公司 A kind of dog interferon preparation biomixer
CN107165027A (en) * 2017-04-25 2017-09-15 杜海燕 A kind of town road repairing road roller
CN107828652A (en) * 2017-10-13 2018-03-23 江苏大学 The cytoactive adjusting method and device of Cell-oriented Activity determination experiment
CN108744322A (en) * 2018-07-09 2018-11-06 北京万孛力医疗器械有限公司 Azoospermia therapeutic equipment

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