CN109998102A - 一种左旋肉碱荷叶绿茶胶囊及其制备方法 - Google Patents
一种左旋肉碱荷叶绿茶胶囊及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种左旋肉碱荷叶绿茶胶囊，其含有以下重量份的原料：左旋肉碱酒石酸盐250‑270份、荷叶提取物30‑40份、绿茶提取物40‑50份、莲子粉70‑80份、柠檬苦素3‑6份。经试验验证，降低了左旋肉碱失眠、心跳加快、头晕、心慌、腹泻等不良反应的发生率，并具有更好的减肥效果。且添加莲子粉后，不需要再添加其他辅料，总混合粉即具有较好的粉体性质，满足胶囊的填充要求。
Description
技术领域
本发明涉一种左旋肉碱荷叶绿茶胶囊及其制备方法。
背景技术
随着社会发展，人们生活水平日益增高，生活节奏也越来越快，目前人们食用的食品、所处的环境及缺少运动等因素，导致很多人处于不健康或亚健康状态，肥胖、高血脂等问题发生几率高。
左旋肉碱(L-carnitine)，又称L-肉碱，是一种促使脂肪转化为能量的类氨基酸，红色肉类是左旋肉碱的主要来源。左旋肉碱是一种天然存在于人体体内的类氨基酸物质，有运输脂肪至线粒体并加速脂肪燃烧和分解的功能，从而让消费者达到减肥瘦身的效果。不同类型的日常饮食已经含有5-100毫克的左旋肉碱，但一般人每天只能从膳食中摄入50毫克，素食者摄入更少。左旋肉碱的主要生理功能是促进脂肪转化成能量，服用左旋肉碱能够在减少身体脂肪、降低体重的同时，不减少水分和肌肉，被认为是较为安全的减肥营养补充品。
如CN201710404140.9公开了一种荷叶左旋肉碱固体饮料及其制作方法。称取左旋肉碱酒石酸盐、荷叶提取物，分别过100目筛，混合均匀，包装，即得。本发明可促使脂肪转化为能量的类氨基酸，对人体无毒副作用，并具有清心解暑、散瘀止血、消风祛湿的功效。目前市场上也有很多含有左旋肉碱的产品，如：纽倍乐牌左旋肉碱荷叶绿茶胶囊，主要原料为左旋肉碱酒石酸盐、荷叶提取物、绿茶提取物，添加荷叶提取物、绿茶提取物增加减肥效果。但左旋肉碱存在导致失眠、心跳加快、头晕、心慌、腹泻、营养不良等副作用，限制了其应用。
发明内容
本发明要解决的技术问题是提供一种效果好，副作用小的左旋肉碱减肥产品。
为解决上述技术问题，本发明公开了一种左旋肉碱荷叶绿茶胶囊，其含有以下重量份的原料：左旋肉碱酒石酸盐250-270份、荷叶提取物30-40份、绿茶提取物40-50份、莲子粉70-80份、柠檬苦素3-6份。
优选含有以下重量份的原料：左旋肉碱酒石酸盐260份、荷叶提取物35份、绿茶提取物45份、莲子粉76份、柠檬苦素4份。
本发明所公开的左旋肉碱荷叶绿茶胶囊，在具有减肥效果的左旋肉碱酒石酸盐、荷叶提取物、绿茶提取物的基础上，增加了合适配比的莲子粉、柠檬苦素，莲子粉补脾止泻，益肾涩精，养心安神；柠檬苦素具有改善睡眠，抗焦虑镇静等保健作用，众成分配合，经试验验证，降低了左旋肉碱失眠、心跳加快、头晕、心慌、腹泻等不良反应的发生率，并具有更好的减肥效果。且添加莲子粉后，不需要再添加其他辅料，总混合粉即具有较好的粉体性质，满足胶囊的填充要求。
所述莲子粉可通过如下步骤制备：a)莲子，去除杂质，干燥；b)初步压碎；c)微粉化。制备步骤a)中莲子优选为新鲜莲子，保有莲心，干燥方式优选为冷冻干燥，制备步骤c)中微粉化方式优选为气流粉碎，气流由低温压缩氮气组成，优选方式制得的莲子粉粉质细腻，粒径均匀，效果佳。
本发明所公开的左旋肉碱荷叶绿茶胶囊，可通过如下步骤制备：a)各原料过筛备用；b)照配方比例称取左旋肉碱酒石酸盐、荷叶提取物、绿茶提取物、莲子粉混合均匀，加入配方量的柠檬苦素混合，得总混合粉；c)将总混合粉末用胶囊充填机填充胶囊，即得。
具体实施方式
以下通过具体实施例再对本发明的上述内容作进一步的详细说明。但不应将此理解为本发明上述主题的范围仅局限于以下的实施例。在不脱离本发明上述技术思想的情况下，根据本领域普通技术知识和惯用手段做出的各种替换或变更，均应包括在本发明的范围内。
实施例1
处方：
| 物料组成 | 用量(kg) |
| 左旋肉碱酒石酸盐 | 25 |
| 荷叶提取物 | 4 |
| 绿茶提取物 | 5 |
| 莲子粉(市售) | 8 |
| 柠檬苦素 | 0.6 |
制备方法：
1)各原料过100目筛备用；
2)照配方比例称取左旋肉碱酒石酸盐、荷叶提取物、绿茶提取物、莲子粉混合均匀，加入配方量的柠檬苦素混合，得总混合粉；
3)将总混合粉末用胶囊充填机填充胶囊(按左旋肉碱酒石酸盐计，260mg/胶囊)，即得。
实施例2
处方：
| 物料组成 | 用量(kg) |
| 左旋肉碱酒石酸盐 | 27 |
| 荷叶提取物 | 3 |
| 绿茶提取物 | 4 |
| 莲子粉(自制) | 7 |
| 柠檬苦素 | 0.3 |
莲子粉自制方法：
1)新鲜莲子，保有莲心，冷冻干燥；
2)初步压碎；
3)4℃压缩氮气气流粉碎，即得。
胶囊制备方法：
1)各原料过100目筛备用；
2)照配方比例称取左旋肉碱酒石酸盐、荷叶提取物、绿茶提取物、莲子粉混合均匀，加入配方量的柠檬苦素混合，得总混合粉；
3)将总混合粉末用胶囊充填机填充胶囊(按左旋肉碱酒石酸盐计，260mg/胶囊)，即得。
实施例3
处方：
制备方法：。
1)各原料过100目筛备用；
2)照配方比例称取左旋肉碱酒石酸盐、荷叶提取物、绿茶提取物、莲子粉混合均匀，加入配方量的柠檬苦素混合，得总混合粉；
3)将总混合粉末用胶囊充填机填充胶囊(按左旋肉碱酒石酸盐计，260mg/胶囊)，即得。
实施例4
处方：
| 物料组成 | 用量(kg) |
| 左旋肉碱酒石酸盐 | 26 |
| 荷叶提取物 | 3.5 |
| 绿茶提取物 | 4.5 |
| 莲子粉(自制) | 7.6 |
| 柠檬苦素 | 0.4 |
莲子粉自制方法：
1)新鲜莲子，保有莲心，冷冻干燥；
2)初步压碎；
3)4℃压缩氮气气流粉碎，即得。
胶囊制备方法：
1)各原料过100目筛备用；
2)照配方比例称取左旋肉碱酒石酸盐、荷叶提取物、绿茶提取物、莲子粉混合均匀，加入配方量的柠檬苦素混合，得总混合粉；
3)将总混合粉末用胶囊充填机填充胶囊(按左旋肉碱酒石酸盐计，260mg/胶囊)，即得。
对照例处方组成：
制备方法同实施例4。
本发明以上实施例所制备的左旋肉碱酒石酸盐胶囊的效果测试结果如下：
1)左旋肉碱荷叶绿茶胶囊动物试验：SPF级雄性SD大鼠110只，体重200～220g，动物适应性喂养3天，按体重随机分为11组，空白对照组、高脂模型对照组及实施例1～4组、对照例1～3组、市售1(纽倍乐牌左旋肉碱荷叶绿茶胶囊)及市售2(修正左旋肉碱茶多酚片)，空白对照组动物喂饲基础饲料，模型对照组和其它实验组动物喂饲高脂饲料。控制各组动物进食量及饮水量基本一致，空白对照组和模型对照组动物饮用蒸馏水，3个实验组动物饮用溶解的胶囊内容物或片剂水溶液(以左旋肉碱酒石酸盐计,30mg/只/天)，持续30天。统计各组动物前后的体重，结果显示实施例1～4组具有良好的控制体重效果，具体结果见表1：
表1
2)左旋肉碱荷叶绿茶胶囊效果验证：选取经检查无器质性病变，仅处于超重状态的女性志愿者，年龄35-45岁，共900名，所有志愿者均肥胖(体重指数BMI28～32)，随机分为9组，分别给予实施例1～4、对照例1～3、市售1(纽倍乐牌左旋肉碱荷叶绿茶胶囊)及市售2(修正左旋肉碱茶多酚片)，每人每天服用左旋肉碱产品(按左旋肉碱酒石酸盐计，780mg/次，每日两次)，连续食用3个月，服用前及服用3个月后对比体重指数均值，并统计不良反应的发生率，结果显示实施例制备的左旋肉碱酒石酸盐胶囊的减肥效果良好，失眠、心跳加快、头晕、心慌、腹泻等不良反应发生率明显降低，具体结果见下表:2：
表2
Claims (6)
1.一种左旋肉碱荷叶绿茶胶囊，其特征在于，含有以下重量份的原料：左旋肉碱酒石酸盐250-270份、荷叶提取物30-40份、绿茶提取物40-50份、莲子粉70-80份、柠檬苦素3-6份。
2.如权利要求1所述的左旋肉碱荷叶绿茶胶囊，其特征在于，含有以下重量份的原料：左旋肉碱酒石酸盐260份、荷叶提取物35份、绿茶提取物45份、莲子粉76份、柠檬苦素4份。
3.如权利要求1所述的左旋肉碱荷叶绿茶胶囊，其特征在于，所述莲子粉通过如下步骤制备：
a)莲子，去除杂质，干燥；
b)初步压碎；
c)微粉化。
4.如权利要求3所述的左旋肉碱荷叶绿茶胶囊，其特征在于，所述莲子粉制备步骤a)中所述莲子为新鲜莲子，干燥方式为冷冻干燥。
5.如权利要求3所述的左旋肉碱荷叶绿茶胶囊，其特征在于，所述莲子粉制备步骤c)中微粉化方式为气流粉碎，气流由低温压缩氮气组成。
6.如权利要求1所述的左旋肉碱荷叶绿茶胶囊的制备方法，其特征在于，包含如下步骤：
a)各原料过筛备用；
b)照配方比例称取左旋肉碱酒石酸盐、荷叶提取物、绿茶提取物、莲子粉混合均匀，加入配方量的柠檬苦素混合，得总混合粉；
c)将总混合粉末用胶囊充填机填充胶囊，即得。
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