CN109593075A - A kind of method that room temperature efficient high-pressure difference continous way extracts seabuckthorn seeds procyanidine - Google Patents
A kind of method that room temperature efficient high-pressure difference continous way extracts seabuckthorn seeds procyanidine Download PDFInfo
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- CN109593075A CN109593075A CN201910011053.6A CN201910011053A CN109593075A CN 109593075 A CN109593075 A CN 109593075A CN 201910011053 A CN201910011053 A CN 201910011053A CN 109593075 A CN109593075 A CN 109593075A
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- Prior art keywords
- pressure difference
- seabuckthorn seeds
- procyanidine
- room temperature
- continous way
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
- C07D311/62—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2 with oxygen atoms directly attached in position 3, e.g. anthocyanidins
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02B—CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO BUILDINGS, e.g. HOUSING, HOUSE APPLIANCES OR RELATED END-USER APPLICATIONS
- Y02B30/00—Energy efficient heating, ventilation or air conditioning [HVAC]
- Y02B30/52—Heat recovery pumps, i.e. heat pump based systems or units able to transfer the thermal energy from one area of the premises or part of the facilities to a different one, improving the overall efficiency
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to a kind of method that room temperature efficient high-pressure difference continous way extracts seabuckthorn seeds procyanidine, 10-40 DEG C of room temperature extraction, solvent is water or ethyl alcohol, concentration of alcohol 10-60%, solid-liquid ratio 1:8-1:30, pressure difference-0.1-50Mpa.Production process temperature of the present invention is low, and moment continous way is extracted, energy conservation and environmental protection, high production efficiency, procyanidine recovery rate height, no solvent residue, product high-quality, meets the requirement of various procyanidine health care products, special doctor's food and drug development.
Description
Technical field:
The present invention relates to the methods that efficient cryogenic extracts proanthocyanidins from seabuckthorm seeds.
Background technique:
20 middle of century, French scientist Maas chief strangle the procyanidine in first discovery plant.By nearly research in 60 years,
The understanding of plant procyanidine health care pharmacological action is continuously improved in people.In recent years, a large amount of research confirms that procyanidine is not
It is only a kind of efficient antioxidant, and is adjustable human body essential biological pathway, participates in many oxygen in basic life process
Change reduction chain reaction process.Research confirms that glucosidase procyanidins have directly or indirectly nearly hundred kinds of body damages and disease
Effect is prevented, treated, there is extensive use in fields such as health care product, special doctor's food, quasi- word drug and cosmetics.
Grape pip procyanidin is always unfailing research topic, currently, still mentioning both at home and abroad by raw material of grape pip
Take procyanidine.Research confirms that seabuckthorn seeds procyanidin extract contains more dimerization than grape pip procyanidin extract
Body, tripolymer, seabuckthorn seeds procyanidine inhibit the effect of oxidation to be better than grape pip procyanidin.For this purpose, extracting seabuckthorn seeds original flower
Green element industrialization, health care product and quasi- word medicine are developed in innovation better health care medicine benefit and bigger ecological environment benefit.
" a method of extract proanthocyanidins from seabuckthorm seeds " patent of invention (ZL2008 1 0176033.6) is using spray
The method that mist dry technology obtains seabuckthorn seeds procyanidine.
" a method of extract proanthocyanidins from seabuckthorm seeds " patent of invention (1 0367195.X of ZL2011) is using super
Sound method is extracted to obtain extracting solution, the method for obtaining proanthocyanidins from seabuckthorm seeds using microwave drying technology.
A kind of " method that low temperature low-energy-consumption high-efficiency extracts sea-buckthorn procyanidins " patent of invention (ZL2016 1
It 0015154.7) is that the extraction of room temperature homogenate extraction technology is used in combination, the concentration of low-temperature negative-pressure heat pump enrichment facility, low-temperature negative-pressure band
The dry method for producing proanthocyanidins from seabuckthorm seeds of formula drying device.
Currently, having no the method that room temperature efficient high-pressure difference continous way extracts seabuckthorn seeds procyanidine.
Summary of the invention:
The technical problem to be solved by the present invention is to supercritical CO is used in combination2Seabuckthorm Seed Oil is extracted in extraction；Its seed dregs of rice uses room
Warm poor (- 0.1 ~ 50Mpa) continous way of (10-40 DEG C) efficient high-pressure extracts seabuckthorn seeds procyanidine extracting solution；(40 DEG C) of low temperature negative
It presses (- 0.098Mpa) heat pump enrichment facility recycling ethyl alcohol and concentrated extracting solution is at medicinal extract, low temperature (50 DEG C) negative pressure (- 0.098Mpa)
The method that extract dry is extracted proanthocyanidins from seabuckthorm seeds at powder, four technologies of use in conjunction by belt drying device.
To solve the above problems, a kind of room temperature efficient high-pressure difference continous way of the present invention extracts seabuckthorn seeds procyanidine
Method,
This method is that the seed dregs of rice after seabuckthorn seeds extraction seed oil extract seabuckthorn seeds original flower using room temperature high-pressure difference continous way extractive technique
Green extract.10 DEG C-50 DEG C of Extracting temperature, solvent be water or ethyl alcohol, concentration of alcohol 10-60%, solid-liquid ratio 1:8-1:30,
High Pressure Difference pressure difference is-0.1-50Mpa.
Specifically comprise the following steps:
A. by supercritical CO2The seed dregs of rice after extraction Seabuckthorm Seed Oil are crushed to 50 ~ 80 mesh, make solvent with water or with ethyl alcohol, impregnate
It 0.5-2 hours, under 10-40 DEG C of states, is continuously extracted using High Pressure Difference-0.1 ~ 50Mpa extraction element, obtains seabuckthorn seeds original flower
Green element water or Diluted Alcohol extracting solution；
B. 10-40 DEG C are used, negative pressure-0.098Mpa heat pump enrichment facility recycles ethyl alcohol and concentrated extracting solution, obtains seabuckthorn seeds original flower
Green element medicinal extract；
C. 20-50 DEG C is used, seabuckthorn seeds proanthocyanidin extract is dried to seabuckthorn seeds original by negative pressure -0.098Mpa belt drying device
Cyanidin extract powder product.
The beneficial outcomes of technical solution of the present invention:
1. High Pressure Difference (- 0.1 ~ 50Mpa) is continuously extracted under room temperature (10-40 DEG C) state of the present invention, production energy-saving is more efficient.
2. room temperature high-pressure difference of the present invention, which is extracted, to be the powerful mechanical force generated using the High Pressure Difference variation of moment and forms height
Speed stream makes raw tissue cell rupture, and active constituent intracellular and solvent come into full contact with direct dissolution, to reach high efficiency extraction
Effect, High Pressure Difference recovery rate be greater than 95%, be much higher than ultrasonic extraction and homogenate extraction method.
3. High Pressure Difference of the present invention, which is extracted, can be achieved continuous extraction, production efficiency is higher than ultrasonic extraction and homogenate extraction
Method.
4. High Pressure Difference of the present invention extract the production cost of seabuckthorn seeds procyanidin extract production technology lower than ultrasonic method and
Homogenate extraction method has stronger industrialization competitiveness.
5. seabuckthorn seeds procyanidin extract yield of the present invention is greater than 15%, moisture is lower than 6%, procyanidin content 30 ~
50%。
Detailed description of the invention:
Attached drawing 1 is process diagram of the invention.
Specific embodiment:
Embodiment 1: a kind of room temperature efficient high-pressure difference extracts seabuckthorn seeds procyanidine and obtains method, includes the following steps:
1) supercritical CO is weighed2Sea-buckthorn seed cake 5kg after extracting Seabuckthorn Oil, is crushed to 50 ~ 80 mesh coarse powder, with the second of 50kg40%
Alcohol impregnates 0.5 hour, is extracted 1 time under 22Mpa pressure using High Pressure Difference device, obtains filtrate 38kg. with 300 mesh filter-cloth filterings
2) 38kg extracting solution using low temperature (20-25 DEG C) negative pressure (- 0.098Mpa) heat pump enrichment facility recycling ethyl alcohol and will be mentioned
Liquid is taken to be condensed into proanthocyanidin extract 1.62kg.
3) 1.62kg proanthocyanidin extract is dry using low temperature (25-30 DEG C) negative pressure (- 0.098Mpa) belt drying device
It is dry to obtain seabuckthorn seeds procyanidin extract pulvis 0.78kg, procyanidin content 48.5%.
Embodiment 2: a kind of room temperature efficient high-pressure difference extracts seabuckthorn seeds procyanidine and obtains method, includes the following steps:
1) supercritical CO is weighed2Sea-buckthorn seed cake 10kg after extracting Seabuckthorn Oil, is crushed to 50 ~ 80 mesh coarse powder, is soaked with 150kg pure water
Bubble 0.5 hour, is extracted 2 times under 25Mpa pressure using High Pressure Difference device, obtains filtrate 125kg. with 300 mesh filter-cloth filterings
2) 125kg extracting solution is condensed into procyanidine leaching using low temperature (30 DEG C) negative pressure (- 0.098Mpa) heat pump enrichment facility
Cream 3.5kg.
3) 3.5kg proanthocyanidin extract is dry using low temperature (30 DEG C) negative pressure (- 0.098Mpa) belt drying device
Seabuckthorn seeds procyanidin extract pulvis 1.60kg, procyanidin content 40.5%.
Claims (3)
1. a kind of method that room temperature efficient high-pressure difference continous way extracts seabuckthorn seeds procyanidine, it is characterised in that: seabuckthorn seeds are extracted
The seed dregs of rice after seed oil extract seabuckthorn seeds procyanidin extract using room temperature high-pressure difference continous way extractive technique.
2. sea-buckthorn seed cake according to claim 1 extracts seabuckthorn seeds procyanidine using room temperature efficient high-pressure difference continous way
Method, it is characterised in that: 10 DEG C-50 DEG C of Extracting temperature, solvent is water or ethyl alcohol, concentration of alcohol 10-60%, solid-liquid ratio 1:8-
1:30, High Pressure Difference pressure difference are-0.1-50Mpa.
3. sea-buckthorn seed cake according to claim 1 or 2 extracts seabuckthorn seeds original cyanine using room temperature efficient high-pressure difference continous way
The method of element, characterized by the following steps:
A. by supercritical CO2The seed dregs of rice after extraction Seabuckthorm Seed Oil are crushed to 50 ~ 80 mesh, make solvent with water or with ethyl alcohol, impregnate 0.5-
It 2 hours, under 10-40 DEG C of states, is continuously extracted using High Pressure Difference-0.1 ~ 50Mpa extraction element, obtains seabuckthorn seeds procyanidine
Water or Diluted Alcohol extracting solution；
B. 10-40 DEG C are used, negative pressure-0.098Mpa heat pump enrichment facility recycles ethyl alcohol and concentrated extracting solution, obtains seabuckthorn seeds original flower
Green element medicinal extract；
C. 20-50 DEG C is used, seabuckthorn seeds proanthocyanidin extract is dried to seabuckthorn seeds original by negative pressure -0.098Mpa belt drying device
Cyanidin extract powder product.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2018111215503 | 2018-09-25 | ||
| CN201811121550 | 2018-09-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109593075A true CN109593075A (en) | 2019-04-09 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201910011053.6A Pending CN109593075A (en) | 2018-09-25 | 2019-01-07 | A kind of method that room temperature efficient high-pressure difference continous way extracts seabuckthorn seeds procyanidine |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117530445A (en) * | 2023-12-22 | 2024-02-09 | 广州泽力医药科技有限公司 | Purple corn compound beverage and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007041514A2 (en) * | 2005-10-03 | 2007-04-12 | Mars, Incorporated | Process for selectively extracting procyanidins |
| CN101386615A (en) * | 2008-11-05 | 2009-03-18 | 中国科学院西北高原生物研究所 | Method for extracting procyanidine from sea-buckthorn seed |
| CN102432578A (en) * | 2011-11-18 | 2012-05-02 | 马映原 | Method for extracting proanthocyanidins from seabuckthorm seeds |
| CN204841021U (en) * | 2015-07-20 | 2015-12-09 | 温州市大成药机制造有限公司 | Concentrated unit of poor cold extraction of high pressure |
| CN105440003A (en) * | 2016-01-12 | 2016-03-30 | 北京宝得瑞健康产业有限公司 | Method for efficiently extracting procyanidine in sea-buckthorn seeds at low temperature and with low energy consumption |
-
2019
- 2019-01-07 CN CN201910011053.6A patent/CN109593075A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007041514A2 (en) * | 2005-10-03 | 2007-04-12 | Mars, Incorporated | Process for selectively extracting procyanidins |
| CN101386615A (en) * | 2008-11-05 | 2009-03-18 | 中国科学院西北高原生物研究所 | Method for extracting procyanidine from sea-buckthorn seed |
| CN102432578A (en) * | 2011-11-18 | 2012-05-02 | 马映原 | Method for extracting proanthocyanidins from seabuckthorm seeds |
| CN204841021U (en) * | 2015-07-20 | 2015-12-09 | 温州市大成药机制造有限公司 | Concentrated unit of poor cold extraction of high pressure |
| CN105440003A (en) * | 2016-01-12 | 2016-03-30 | 北京宝得瑞健康产业有限公司 | Method for efficiently extracting procyanidine in sea-buckthorn seeds at low temperature and with low energy consumption |
Non-Patent Citations (1)
| Title |
|---|
| 王华 等: "高压差连续式提取法与超声提取法提取化橘红中黄酮类物质的比较研究", 《现代化中药制剂发展与中药药理学研究交流会》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117530445A (en) * | 2023-12-22 | 2024-02-09 | 广州泽力医药科技有限公司 | Purple corn compound beverage and preparation method thereof |
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