CN102432578A - Method for extracting proanthocyanidins from seabuckthorm seeds - Google Patents
Method for extracting proanthocyanidins from seabuckthorm seeds Download PDFInfo
- Publication number
- CN102432578A CN102432578A CN201110367195XA CN201110367195A CN102432578A CN 102432578 A CN102432578 A CN 102432578A CN 201110367195X A CN201110367195X A CN 201110367195XA CN 201110367195 A CN201110367195 A CN 201110367195A CN 102432578 A CN102432578 A CN 102432578A
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- China
- Prior art keywords
- seed
- proanthocyanidins
- seabuckthorm
- extracting
- pycnogenols
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 229920002770 condensed tannin Polymers 0.000 title claims abstract description 42
- 238000000034 method Methods 0.000 title claims abstract description 35
- 239000000284 extract Substances 0.000 claims abstract description 17
- 238000001035 drying Methods 0.000 claims abstract description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 13
- 238000005516 engineering process Methods 0.000 claims abstract description 8
- 235000015112 vegetable and seed oil Nutrition 0.000 claims abstract description 8
- 241000229143 Hippophae Species 0.000 claims description 36
- 235000018192 pine bark supplement Nutrition 0.000 claims description 30
- 235000003935 Hippophae Nutrition 0.000 claims description 25
- XFZJEEAOWLFHDH-UHFFFAOYSA-N (2R,2'R,3R,3'R,4R)-3,3',4',5,7-Pentahydroxyflavan(48)-3,3',4',5,7-pentahydroxyflavan Natural products C=12OC(C=3C=C(O)C(O)=CC=3)C(O)CC2=C(O)C=C(O)C=1C(C1=C(O)C=C(O)C=C1O1)C(O)C1C1=CC=C(O)C(O)=C1 XFZJEEAOWLFHDH-UHFFFAOYSA-N 0.000 claims description 13
- CWEZAWNPTYBADX-UHFFFAOYSA-N Procyanidin Natural products OC1C(OC2C(O)C(Oc3c2c(O)cc(O)c3C4C(O)C(Oc5cc(O)cc(O)c45)c6ccc(O)c(O)c6)c7ccc(O)c(O)c7)c8c(O)cc(O)cc8OC1c9ccc(O)c(O)c9 CWEZAWNPTYBADX-UHFFFAOYSA-N 0.000 claims description 13
- MOJZMWJRUKIQGL-FWCKPOPSSA-N Procyanidin C2 Natural products O[C@@H]1[C@@H](c2cc(O)c(O)cc2)Oc2c([C@H]3[C@H](O)[C@@H](c4cc(O)c(O)cc4)Oc4c3c(O)cc(O)c4)c(O)cc(O)c2[C@@H]1c1c(O)cc(O)c2c1O[C@@H]([C@H](O)C2)c1cc(O)c(O)cc1 MOJZMWJRUKIQGL-FWCKPOPSSA-N 0.000 claims description 13
- 229920002414 procyanidin Polymers 0.000 claims description 13
- HGVVOUNEGQIPMS-UHFFFAOYSA-N procyanidin Chemical compound O1C2=CC(O)=CC(O)=C2C(O)C(O)C1(C=1C=C(O)C(O)=CC=1)OC1CC2=C(O)C=C(O)C=C2OC1C1=CC=C(O)C(O)=C1 HGVVOUNEGQIPMS-UHFFFAOYSA-N 0.000 claims description 13
- 235000003145 Hippophae rhamnoides Nutrition 0.000 claims description 11
- 235000007164 Oryza sativa Nutrition 0.000 claims description 3
- 235000009566 rice Nutrition 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 2
- 241000209094 Oryza Species 0.000 claims 2
- 238000000605 extraction Methods 0.000 abstract description 15
- 238000004519 manufacturing process Methods 0.000 abstract description 7
- 239000002904 solvent Substances 0.000 abstract description 4
- 239000003814 drug Substances 0.000 abstract description 2
- 235000012054 meals Nutrition 0.000 abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 description 6
- 239000011347 resin Substances 0.000 description 5
- 229920005989 resin Polymers 0.000 description 5
- 241000219095 Vitis Species 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 3
- 239000000287 crude extract Substances 0.000 description 3
- 238000007670 refining Methods 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 235000009392 Vitis Nutrition 0.000 description 2
- 235000009754 Vitis X bourquina Nutrition 0.000 description 2
- 235000012333 Vitis X labruscana Nutrition 0.000 description 2
- 235000014787 Vitis vinifera Nutrition 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000000539 dimer Substances 0.000 description 2
- XMOCLSLCDHWDHP-IUODEOHRSA-N epi-Gallocatechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@H]2O)=CC(O)=C(O)C(O)=C1 XMOCLSLCDHWDHP-IUODEOHRSA-N 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 210000000582 semen Anatomy 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 description 1
- 239000009140 Grape Seed Proanthocyanidin Substances 0.000 description 1
- XMOCLSLCDHWDHP-UHFFFAOYSA-N L-Epigallocatechin Natural products OC1CC2=C(O)C=C(O)C=C2OC1C1=CC(O)=C(O)C(O)=C1 XMOCLSLCDHWDHP-UHFFFAOYSA-N 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 229920000124 Prodelphinidin Polymers 0.000 description 1
- 229930182448 Prodelphinidin Natural products 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 1
- 235000005487 catechin Nutrition 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229950001002 cianidanol Drugs 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- DZYNKLUGCOSVKS-UHFFFAOYSA-N epigallocatechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3cc(O)c(O)c(O)c3 DZYNKLUGCOSVKS-UHFFFAOYSA-N 0.000 description 1
- 239000000469 ethanolic extract Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000013467 fragmentation Methods 0.000 description 1
- 238000006062 fragmentation reaction Methods 0.000 description 1
- 229940098326 grape seed proanthocyanidins Drugs 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- -1 tripolymer Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
Images
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (3)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201110367195.XA CN102432578B (en) | 2011-11-18 | 2011-11-18 | Method for extracting proanthocyanidins from seabuckthorm seeds |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201110367195.XA CN102432578B (en) | 2011-11-18 | 2011-11-18 | Method for extracting proanthocyanidins from seabuckthorm seeds |
Publications (2)
Publication Number | Publication Date |
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CN102432578A true CN102432578A (en) | 2012-05-02 |
CN102432578B CN102432578B (en) | 2015-06-10 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201110367195.XA Active CN102432578B (en) | 2011-11-18 | 2011-11-18 | Method for extracting proanthocyanidins from seabuckthorm seeds |
Country Status (1)
Country | Link |
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CN (1) | CN102432578B (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102755359A (en) * | 2012-07-19 | 2012-10-31 | 中国科学院研究生院 | Hippophae extract and preparation method and application thereof for inhibiting activity of fatty acid synthase |
CN104997109A (en) * | 2015-08-06 | 2015-10-28 | 贵州三农楮桃产业开发有限公司 | Broussonetia papyrifera pulp rich in proanthocyanidins as well as preparation method and application of broussonetia papyrifera pulp |
CN105440003A (en) * | 2016-01-12 | 2016-03-30 | 北京宝得瑞健康产业有限公司 | Method for efficiently extracting procyanidine in sea-buckthorn seeds at low temperature and with low energy consumption |
CN109133272A (en) * | 2018-08-24 | 2019-01-04 | 青海清华博众生物技术有限公司 | A kind of purification process of plateau ecology hard water |
CN109593075A (en) * | 2018-09-25 | 2019-04-09 | 宝得瑞(湖北)健康产业有限公司 | A kind of method that room temperature efficient high-pressure difference continous way extracts seabuckthorn seeds procyanidine |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08205818A (en) * | 1995-02-01 | 1996-08-13 | Nonogawa Shoji Kk | Health food and medicine formulated with procyanidin |
JPH10218769A (en) * | 1997-02-06 | 1998-08-18 | Kikkoman Corp | Antiulcer agent |
EP1388343A1 (en) * | 2002-08-09 | 2004-02-11 | Eromlife Co., Ltd. | Antioxidant composition and method of preparation thereof |
CN101386615A (en) * | 2008-11-05 | 2009-03-18 | 中国科学院西北高原生物研究所 | Method for extracting procyanidine from sea-buckthorn seed |
CN101496581A (en) * | 2008-02-03 | 2009-08-05 | 于珩 | Health-care food for adjusting blood fat |
CN101701013A (en) * | 2009-11-05 | 2010-05-05 | 中国林业科学研究院林产化学工业研究所 | Method for extracting proanthocyanidin from pine bark by taking water as solvent |
CN101768621A (en) * | 2010-02-11 | 2010-07-07 | 青海康普生物科技股份有限公司 | Method for preparing sea-buckthorn enzymes from seabuckthorn fruit mud |
-
2011
- 2011-11-18 CN CN201110367195.XA patent/CN102432578B/en active Active
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08205818A (en) * | 1995-02-01 | 1996-08-13 | Nonogawa Shoji Kk | Health food and medicine formulated with procyanidin |
JPH10218769A (en) * | 1997-02-06 | 1998-08-18 | Kikkoman Corp | Antiulcer agent |
EP1388343A1 (en) * | 2002-08-09 | 2004-02-11 | Eromlife Co., Ltd. | Antioxidant composition and method of preparation thereof |
CN101496581A (en) * | 2008-02-03 | 2009-08-05 | 于珩 | Health-care food for adjusting blood fat |
CN101386615A (en) * | 2008-11-05 | 2009-03-18 | 中国科学院西北高原生物研究所 | Method for extracting procyanidine from sea-buckthorn seed |
CN101701013A (en) * | 2009-11-05 | 2010-05-05 | 中国林业科学研究院林产化学工业研究所 | Method for extracting proanthocyanidin from pine bark by taking water as solvent |
CN101768621A (en) * | 2010-02-11 | 2010-07-07 | 青海康普生物科技股份有限公司 | Method for preparing sea-buckthorn enzymes from seabuckthorn fruit mud |
Non-Patent Citations (2)
Title |
---|
杜学禹等: "加勒比松树皮中原花青素的提取工艺研究", 《生物质化学工程》 * |
金海英等: "沙棘籽渣中低聚原花青素提取和精致工艺研究", 《沙棘》 * |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102755359A (en) * | 2012-07-19 | 2012-10-31 | 中国科学院研究生院 | Hippophae extract and preparation method and application thereof for inhibiting activity of fatty acid synthase |
CN102755359B (en) * | 2012-07-19 | 2014-04-02 | 中国科学院研究生院 | Hippophae extract and preparation method and application thereof for inhibiting activity of fatty acid synthase |
CN104997109A (en) * | 2015-08-06 | 2015-10-28 | 贵州三农楮桃产业开发有限公司 | Broussonetia papyrifera pulp rich in proanthocyanidins as well as preparation method and application of broussonetia papyrifera pulp |
CN105440003A (en) * | 2016-01-12 | 2016-03-30 | 北京宝得瑞健康产业有限公司 | Method for efficiently extracting procyanidine in sea-buckthorn seeds at low temperature and with low energy consumption |
CN105440003B (en) * | 2016-01-12 | 2017-11-17 | 北京宝得瑞健康产业有限公司 | A kind of method of low temperature low-energy-consumption high-efficiency extraction proanthocyanidins from seabuckthorm seeds |
CN109133272A (en) * | 2018-08-24 | 2019-01-04 | 青海清华博众生物技术有限公司 | A kind of purification process of plateau ecology hard water |
CN109593075A (en) * | 2018-09-25 | 2019-04-09 | 宝得瑞(湖北)健康产业有限公司 | A kind of method that room temperature efficient high-pressure difference continous way extracts seabuckthorn seeds procyanidine |
Also Published As
Publication number | Publication date |
---|---|
CN102432578B (en) | 2015-06-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
ASS | Succession or assignment of patent right |
Owner name: MA YINGYUAN Effective date: 20120525 Owner name: BEIJING POWDERY FOOD CO., LTD. Free format text: FORMER OWNER: MA YINGYUAN Effective date: 20120525 |
|
C41 | Transfer of patent application or patent right or utility model | ||
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 100123 CHAOYANG, BEIJING TO: 101117 TONGZHOU, BEIJING |
|
TA01 | Transfer of patent application right |
Effective date of registration: 20120525 Address after: 101117 Beijing City Lucheng town Tongzhou District City Industrial Zone No. 15 Applicant after: Beijing Powdery Food Co., Ltd. Co-applicant after: Ma Yingyuan Address before: 100123, room 1, unit 5, 102 middle building, Chaoyang District manna garden, Beijing Applicant before: Ma Yingyuan |
|
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant |