CN109563039A - 一种羟尼酮的制备方法 - Google Patents

一种羟尼酮的制备方法 Download PDF

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Publication number
CN109563039A
CN109563039A CN201780048603.0A CN201780048603A CN109563039A CN 109563039 A CN109563039 A CN 109563039A CN 201780048603 A CN201780048603 A CN 201780048603A CN 109563039 A CN109563039 A CN 109563039A
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CN
China
Prior art keywords
formula
compound
ethyl acetate
methyl
purification
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201780048603.0A
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English (en)
Inventor
罗楹
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BEIJING CONTINENT PHARMACEUTICAL Co.,Ltd.
Original Assignee
Tianjin Ruiying Biological Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tianjin Ruiying Biological Co Ltd filed Critical Tianjin Ruiying Biological Co Ltd
Publication of CN109563039A publication Critical patent/CN109563039A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)

Abstract

提供了一种羟尼酮的制备方法，操作简便、反应条件温和、反应时间短、产率高，更安全且适用于大生产。本发明采用氨水处理中间化合物粗品，既有利于去除催化剂中残留的铜离子，又有利于产物析出。

Description

PCT国内申请，说明书已公开。

Claims (10)

  1. PCT国内申请，权利要求书已公开。
CN201780048603.0A 2016-08-08 2017-08-03 一种羟尼酮的制备方法 Pending CN109563039A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2016106425150 2016-08-08
CN201610642515.0A CN107698499A (zh) 2016-08-08 2016-08-08 一种羟尼酮的制备方法
PCT/CN2017/095882 WO2018028508A1 (zh) 2016-08-08 2017-08-03 一种羟尼酮的制备方法

Publications (1)

Publication Number Publication Date
CN109563039A true CN109563039A (zh) 2019-04-02

Family

ID=61161577

Family Applications (3)

Application Number Title Priority Date Filing Date
CN201610642515.0A Pending CN107698499A (zh) 2016-08-08 2016-08-08 一种羟尼酮的制备方法
CN202310048439.0A Pending CN116082225A (zh) 2016-08-08 2016-08-08 一种羟尼酮的制备方法
CN201780048603.0A Pending CN109563039A (zh) 2016-08-08 2017-08-03 一种羟尼酮的制备方法

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Application Number Title Priority Date Filing Date
CN201610642515.0A Pending CN107698499A (zh) 2016-08-08 2016-08-08 一种羟尼酮的制备方法
CN202310048439.0A Pending CN116082225A (zh) 2016-08-08 2016-08-08 一种羟尼酮的制备方法

Country Status (3)

Country Link
JP (1) JP6764999B2 (zh)
CN (3) CN107698499A (zh)
WO (1) WO2018028508A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111004173A (zh) * 2019-12-31 2020-04-14 北京康蒂尼药业有限公司 一种羟尼酮的制备方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005047256A1 (fr) * 2003-11-14 2005-05-26 Shanghai Genomics, Inc. Derives de pyridone, et utilisation correspondante
CN101165051A (zh) * 2007-08-07 2008-04-23 中国科学院长春应用化学研究所 树枝状主体材料及该化合物制备的有机电致发光器件
CN101723883A (zh) * 2008-10-24 2010-06-09 上海睿星基因技术有限公司 一种羟尼酮的制备方法
CN102099036A (zh) * 2008-06-03 2011-06-15 英特芒尼公司 用于治疗炎性疾患和纤维化疾患的化合物和方法
CN102766041A (zh) * 2012-08-17 2012-11-07 济南大学 一种水杨醛衍生物中间体的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0129260D0 (en) * 2001-12-06 2002-01-23 Eisai London Res Lab Ltd Pharmaceutical compositions and their uses
PE20080150A1 (es) * 2006-06-02 2008-04-11 Janssen Pharmaceutica Nv Derivados de piridinona n-aril y n-heteroaril sustituidos como antagonistas del receptor de la hormona concentradora de melanina (mch)
ES2483866T3 (es) * 2006-12-05 2014-08-08 Janssen Pharmaceutica Nv Derivados de diaza-espiro-piridinona sustituidos novedosos para uso en enfermedades mediadas por MCH-1
KR20090082484A (ko) * 2006-12-14 2009-07-30 일라이 릴리 앤드 캄파니 5-[4-(아제티딘-3-일옥시)-페닐]-2-페닐-5ｈ-티아졸로[5,4-ｃ]피리딘-4-온 유도체 및 ｍｃｈ 수용체 길항제로서의 이들의 용도
AR092742A1 (es) * 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
AU2017213690A1 (en) * 2016-02-01 2018-08-16 3M Innovative Properties Company Adhesive compositions

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005047256A1 (fr) * 2003-11-14 2005-05-26 Shanghai Genomics, Inc. Derives de pyridone, et utilisation correspondante
CN101165051A (zh) * 2007-08-07 2008-04-23 中国科学院长春应用化学研究所 树枝状主体材料及该化合物制备的有机电致发光器件
CN102099036A (zh) * 2008-06-03 2011-06-15 英特芒尼公司 用于治疗炎性疾患和纤维化疾患的化合物和方法
CN101723883A (zh) * 2008-10-24 2010-06-09 上海睿星基因技术有限公司 一种羟尼酮的制备方法
CN102766041A (zh) * 2012-08-17 2012-11-07 济南大学 一种水杨醛衍生物中间体的制备方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
能源部西安热工研究所主编: "《热工技术手册》", 30 June 1993 *

Also Published As

Publication number Publication date
CN116082225A (zh) 2023-05-09
WO2018028508A1 (zh) 2018-02-15
JP6764999B2 (ja) 2020-10-07
CN107698499A (zh) 2018-02-16
JP2019525946A (ja) 2019-09-12

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