CN109395025A - A kind of Medical cold application and preparation method thereof improving children's functions of intestines and stomach - Google Patents
A kind of Medical cold application and preparation method thereof improving children's functions of intestines and stomach Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
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Abstract
The invention discloses a kind of Medical-use cold compress notes for improving children's functions of intestines and stomach, including non-woven fabrics, the activity extract and hydrogel that are coated on non-woven fabrics, and the release paper being bonded with non-woven fabrics；The activity extract is hyacinth bean, rhizome of chuanxiong, semen coicis, curcuma zedoary, rheum officinale, borneol, fennel seeds, Rhizoma Gastrodiae, Schisandra chinensis, Herba Cistanches, Kadsura Root-bark and the extract of leech；Weight ratio 1:1~5 of the activity extract and hydrogel.The preparation method that the Medical cold that the invention also discloses a kind of for improving children's functions of intestines and stomach applies.The effect of Medical-use cold compress note that the present invention improves children's functions of intestines and stomach has and improves vomiting in children, fever symptoms, improves the symptoms such as children's times of defecation is frequent, the dilute water sample of stool or egg soup sample, stool fat globule content are reduced or disappeared rapidly.
Description
Technical field
The present invention relates to children's curable product fields more particularly to a kind of for improving the Medical-use cold compress of children's functions of intestines and stomach
Patch further relates to a kind of preparation method that the Medical cold for improving children's functions of intestines and stomach applies.
Background technique
Children's functions of intestines and stomach is anomaly divided into the abnormal and non-infectious functions of intestines and stomach exception of infectious functions of intestines and stomach, cardinal symptom
It shows as diarrhea abdominal distension, weakness of the spleen and the stomach, vomiting, abnormal heat, stool frequency and is in dilute water egg flower sample, loss of appetite, spiritual worry, night
Bedroom is kept crying.Infectious functions of intestines and stomach is mainly caused by reasons such as virus, bacterium or helminths extremely, is often popular in the autumn and winter
Season.Non-infectious functions of intestines and stomach is mainly that climatic factor and dietary factor cause extremely.
It is abnormal to treat children's functions of intestines and stomach, doctor trained in Western medicine mostly uses intestinal mucosa protective agent and Tiny ecosystem therapy, functions of intestines and stomach different
Though normal symptom has certain improvement, the course for the treatment of is longer, and infant is difficult to take by the course for the treatment of, it is difficult to reach therapeutic purposes.In addition, when long
Between oral western medicine, functions of intestines and stomach and immune system itself for children's fragility there is also certain challenge, be unfavorable for children from
The growth and health of body.
Children's functions of intestines and stomach exception course of disease is longer, if selection oral traditional Chinese medicine treatment leads to mouth mostly because infant eats medicine suffering
Clothes are difficult to reach expected curative effect, and delay treatment influences infant growth and development, can't bear infants' pain, and doctor and parent are anxious
It cuts serious hope and alleviates infants' pain as early as possible.For example, traditional treatment mainly applies potent astringent, such as common small for treating
The medicine of youngster's functions of intestines and stomach exception includes children's stomach health, can be used for The flat liver of heat-clearing, and function of spleen and stomach regulating gut function is abnormal, improves appetite not
Vibration, diarrhea abdominal distension.But such drug is more difficult in use, because such drug is usually oral, pharmaceutical activity
Ingredient includes the bitter tastes Chinese medicine compositions such as Radix Codonopsis, cicada slough, cicada sand, and children, which often repel, takes orally such drug, feeds and deposits by force
Enter the risk of tracheae, cough of choking in medical fluid, thus hinders the treatment to children's functions of intestines and stomach malaise symptoms.Still further aspect,
Slowly, needing to carry out conditioning for a long time can take effect, therefore also increases and treated by herbal treatment for traditional Chinese medicine ingredients effect itself
The difficulty of children's functions of intestines and stomach exception.
As motherland's medicine deepens continuously to children's functions of intestines and stomach Anomaly, developing a kind of is suitable for making for a long time
With, facilitate children to use, the external application formula with good conditioning children's functions of intestines and stomach exception, it is big hot to become one studied instantly
Point.
Summary of the invention
For overcome the deficiencies in the prior art, one of the objects of the present invention is to provide a kind of improvement children's functions of intestines and stomach
Medical-use cold compress note, with solve it is above-mentioned be not suitable for using for a long time, inconvenient children use, conditioning children's functions of intestines and stomach exception effect
The problems such as poor.
The second object of the present invention is to provide a kind of preparation method of Medical-use cold compress note for improving children's functions of intestines and stomach, lead to
Cross this method and prepare the Medical-use cold compress note for improving children's functions of intestines and stomach, with solve it is above-mentioned be not suitable for using for a long time, it is inconvenient
The problems such as children use, conditioning children's functions of intestines and stomach exception effect is poor.
An object of the present invention adopts the following technical scheme that realization:
A kind of Medical-use cold compress note improving children's functions of intestines and stomach is extracted including non-woven fabrics, the activity being coated on non-woven fabrics
Object and hydrogel, and the release paper being bonded with non-woven fabrics；
The activity extract is hyacinth bean, rhizome of chuanxiong, semen coicis, curcuma zedoary, rheum officinale, borneol, fennel seeds, Rhizoma Gastrodiae, Schisandra chinensis, meat
Desert cistanche, Kadsura Root-bark and the extract of leech；
Weight ratio 1:1~5 of the activity extract and hydrogel.
Further, by weight, the hyacinth bean is 2~10 parts, and the rhizome of chuanxiong is 5~20 parts, and the semen coicis is 3
~9 parts, the curcuma zedoary is 1~5 part, and the rheum officinale is 4~12 parts, and the borneol is 2~8 parts, and the fennel seeds are 1~5 part,
The Rhizoma Gastrodiae is 3~15 parts, and the Schisandra chinensis is 6~16 parts, and the Herba Cistanches are 3~12 parts, and the Kadsura Root-bark is 32~56
Part, the leech is 4~20 parts.
Further, by weight, the hyacinth bean is 3~7 parts, and the rhizome of chuanxiong is 8~15 parts, and the semen coicis is 5
~8 parts, the curcuma zedoary is 2~4 parts, and the rheum officinale is 6~10 parts, and the borneol is 4~6 parts, and the fennel seeds are 2~4 parts,
The Rhizoma Gastrodiae is 6~10 parts, and the Schisandra chinensis is 8~13 parts, and the Herba Cistanches are 5~10 parts, and the Kadsura Root-bark is 40~48
Part, the leech is 8~15 parts.
Further, by weight, the hyacinth bean is 5 parts, and the rhizome of chuanxiong is 12 parts, and the semen coicis is 7 parts, described
Curcuma zedoary is 3 parts, and the rheum officinale is 8 parts, and the borneol is 5 parts, and the fennel seeds are 3 parts, and the Rhizoma Gastrodiae is 8 parts, the five tastes
Son is 11 parts, and the Herba Cistanches are 7 parts, and the Kadsura Root-bark is 46 parts, and the leech is 12 parts.
The second object of the present invention adopts the following technical scheme that realization:
The preparation method of the Medical-use cold compress note described in any of the above embodiments for improving children's functions of intestines and stomach, includes the following steps,
Stock: take hyacinth bean, rhizome of chuanxiong, semen coicis, curcuma zedoary and Rhizoma Gastrodiae constituent component A, take Schisandra chinensis, fennel seeds, Kadsura Root-bark and
Leech constituent component B takes rheum officinale, borneol and Herba Cistanches constituent component C, component A, B and C is pulverized, and crosses 10~40 meshes；
Medicinal extract is extracted in preparation first: Xiang Zufen A adds 100~200 parts of ammonium hydroxide of 1~5mol/L, impregnates 0.5~2.5h,
Filtering, collect filtrate, filtrate be transferred to Rotary Evaporators be concentrated under reduced pressure into it is thick, thickening temperature be 55~75 DEG C, very
Reciprocal of duty cycle is -0.08~-0.16MPa, is made first and extracts medicinal extract；
Preparation the second extraction medicinal extract: 200~500 parts of ether of addition flow back and mention in the filter residue of Xiang Zufen A after filtering
1.5~4.5h is taken, Extracting temperature is 35~45 DEG C, separates ether and extract, is made second and extracts medicinal extract；
It prepares third and extracts medicinal extract: adding 80~150 parts of ethyl alcohol of 60%~80% in Xiang Zufen B, 70~85 DEG C next time
Stream extract 0.5~3h, filtering, filtrate be transferred to Rotary Evaporators be concentrated under reduced pressure into it is thick, thickening temperature be 55~75
DEG C, vacuum degree is -0.05~-0.12MPa, and third is made and extracts medicinal extract；
It prepares the 4th extraction medicinal extract: adding 100~220 parts of pure water in Xiang Zufen C, decoct 1~3.5h, decoction liquor is turned
Move to Rotary Evaporators be concentrated under reduced pressure into it is thick, thickening temperature be 75~95 DEG C, vacuum degree be -0.02~-
0.12MPa is made the 4th and extracts medicinal extract；
Coated and molded: medicinal extract, the second extraction medicinal extract, third are extracted by first and extracts medicinal extract, the 4th extraction medicinal extract and water-setting
Glue is uniformly mixed, and is spread evenly across on non-woven fabrics, and release paper is bonded, and the Medical-use cold compress note for improving children's functions of intestines and stomach is made.
Further, it is extracted in medicinal extract step in preparation first, the dosage of ammonium hydroxide is 120~150 parts, and the concentration of ammonium hydroxide is
2~3.5mol/L, soaking time 1.5h, thickening temperature are 65 DEG C, and vacuum degree is -0.1MPa.
Further, it is extracted in medicinal extract step in preparation second, ether dosage is 320 parts, and reflux extracting time 3h is mentioned
Taking temperature is 39 DEG C.
Further, it is extracted in medicinal extract step in preparation third, the dosage of 75% ethyl alcohol is 100~120 parts, and reflux mentions
Take temperature be 80 DEG C, reflux extracting time be 1.5~2.5h, thickening temperature be 63~68 DEG C, vacuum degree be -0.08~-
0.1MPa。
Further, it is extracted in medicinal extract step in preparation the 4th, the dosage of pure water is 140~180 parts, and decocting time is
1.5~2.5h, thickening temperature are 80~85 DEG C, and vacuum degree is -0.05~-0.09MPa.
Further, in coated and molded step, by weight, the first extraction medicinal extract, the second extraction medicinal extract, third are mentioned
Take the ratio between summation and hydrogel of medicinal extract and the 4th extraction medicinal extract for 1:2.
Compared with prior art, the beneficial effects of the present invention are:
(1) present invention improves the Medical-use cold compress note of children's functions of intestines and stomach, in use, only needing to take off release paper, by non-woven fabrics
It is coated with activity extract to spread on one side at children's SHENQUE acupoint, children is facilitated to use.Fitting can be played fast for 2~5 hours
Speed improves vomiting in children, fever symptoms, improve rapidly children's times of defecation is frequent, the dilute water sample of stool or egg soup sample,
Fat globule content of defecating reduces or the symptoms such as disappearance.
(2) present invention improves the preparation method of the Medical-use cold compress note of children's functions of intestines and stomach, the improvement prepared by this method
The Medical-use cold compress note of children's functions of intestines and stomach can be effectively retained the effective component of various activity extracts, by means of each effective component
Compounding effect, play conditioning children's stomach, enhancing child physical endowment and immunity and other effects, help children's normal growth and hair
It educates.
Specific embodiment
In the following, being described further in conjunction with specific embodiment to the present invention, it should be noted that is do not collided
Under the premise of, new embodiment can be formed between various embodiments described below or between each technical characteristic in any combination.
Hereinafter, by Examples 1 to 5 the present invention will be described in detail improve children's functions of intestines and stomach Medical-use cold compress note preparation
Journey.Following Extracting temperature and thickening temperature are the temperature of thermostat water bath.
Embodiment 1
Material preparation step: the hyacinth bean 100g dried, rhizome of chuanxiong 200g, semen coicis 30g, curcuma zedoary 10g and Rhizoma Gastrodiae 150g group are taken in groups
Divide A, takes the Schisandra chinensis 160g dried, fennel seeds 10g, Kadsura Root-bark 320g and leech 200g constituent component B, take the rheum officinale dried
40g, borneol 20g and Herba Cistanches 30g constituent component C.Component A, component B and component C are pulverized using grinding machine for Chinese herb medicines, mistake
10 meshes, it is spare.
Preparation the first extraction medicinal extract step: component A is transferred in round-bottomed flask, adds 1mol/L's into round-bottomed flask
Ammonium hydroxide 200ml.Round-bottomed flask 2.5h is shaken with the revolving speed of 100r/min, the mixed liquor in round-bottomed flask is used into double gauze mistake
Filtrate is collected in filter, and filtrate, which is transferred to Rotary Evaporators and be concentrated under reduced pressure into, thick (concentrate wall built-up occurs in evaporative flask
Phenomenon), thickening temperature is 55 DEG C, and vacuum degree is -0.16MPa, is thus made first and extracts medicinal extract.
Preparation the second extraction medicinal extract step: extracting the filter residue collected in medicinal extract step for first and be transferred in round-bottomed flask,
Into round-bottomed flask add 200ml ether be uniformly mixed, round-bottomed flask is transferred in 45 DEG C of thermostat water bath rotated,
Refluxing extraction 4.5h.After refluxing extraction process, by heating evaporation ether, remaining extract is in medicinal extract in round-bottomed flask
Shape (if it is too thick or in bulk, 75% a small amount of ethyl alcohol can be added, reconcile into medicinal extract shape), thus be made second extract
Medicinal extract.
Preparation third extracts medicinal extract step: component B being transferred in round-bottomed flask, adds 150ml into the round-bottomed flask
The ethanol solution that mass fraction is 60% is uniformly mixed.The thermostat water bath that round-bottomed flask is transferred to 70 DEG C is carried out reflux to mention
3h is taken, extraction process terminates.Double gauze filtering, obtains extracting solution.Filtrate is transferred to Rotary Evaporators to be concentrated under reduced pressure, until
Third extraction medicinal extract is made in thick, stopping reduced pressure in extract.Wherein, the temperature of reduced pressure is 55 DEG C, is depressurized dense
The vacuum degree of contracting is -0.12MPa.
It prepares the 4th extraction medicinal extract step: component C being transferred in casserole medicinal cupping, adds 100ml into the casserole medicinal cupping
Pure water (is also required to guarantee water by addition pure water in decoction process), is stirred to be placed on mild fire and decocts
3.5h casserole medicinal cupping is stirred continuously or vibrated in decoction process.After decoction, natural cooling, by the double-deck yarn of decoction liquor
Cloth filtering, filtrate be transferred to Rotary Evaporators be concentrated under reduced pressure into it is thick.Wherein, the temperature of reduced pressure is 95 DEG C, is subtracted
The vacuum degree of pressure concentration is -0.02MPa.
Coated and molded step: medicinal extract, the second extraction medicinal extract, third are extracted by the first of above-mentioned preparation and extracts medicinal extract, the 4th
It extracts medicinal extract and hydrogel is uniformly mixed, wherein the first extraction medicinal extract, the second extraction medicinal extract, third extraction medicinal extract and the 4th mention
It takes the gross weight of medicinal extract and hydrogel weight ratio is 1:5.By above-mentioned uniformly mixed activity extract and hydrogel even spread
In on 40 non-woven fabrics, release paper is covered, the Medical-use cold compress note for improving children's functions of intestines and stomach is made.
Embodiment 2
Material preparation step: the hyacinth bean 30g dried, rhizome of chuanxiong 150g, semen coicis 50g, curcuma zedoary 40g and Rhizoma Gastrodiae 100g constituent component are taken
A takes the Schisandra chinensis 80g dried, fennel seeds 40g, Kadsura Root-bark 4000g and leech 150g constituent component B, take the rheum officinale 60g dried,
Borneol 60g and Herba Cistanches 50g constituent component C.Component A, component B and component C are pulverized using grinding machine for Chinese herb medicines, cross 20 mesh
Sieve, it is spare.
Preparation the first extraction medicinal extract step: component A is transferred in round-bottomed flask, adds 2mol/L's into round-bottomed flask
Ammonium hydroxide 150ml.Round-bottomed flask 0.5h is shaken with the revolving speed of 150r/min, the mixed liquor in round-bottomed flask is used into double gauze mistake
Filtrate is collected in filter, and filtrate, which is transferred to Rotary Evaporators and be concentrated under reduced pressure into, thick (concentrate wall built-up occurs in evaporative flask
Phenomenon), thickening temperature is 60 DEG C, and vacuum degree is -0.13MPa, is thus made first and extracts medicinal extract.
Preparation the second extraction medicinal extract step: extracting the filter residue collected in medicinal extract step for first and be transferred in round-bottomed flask,
Into round-bottomed flask add 260ml ether be uniformly mixed, round-bottomed flask is transferred in 42 DEG C of thermostat water bath rotated,
Refluxing extraction 4h.After refluxing extraction process, by heating evaporation ether, remaining extract is in medicinal extract shape in round-bottomed flask
If (it is too thick or in bulk, 75% a small amount of ethyl alcohol can be added, reconcile into medicinal extract shape), thus be made second extract leaching
Cream.
Preparation third extracts medicinal extract step: component B being transferred in round-bottomed flask, adds 100ml into the round-bottomed flask
The ethanol solution that mass fraction is 80% is uniformly mixed.The thermostat water bath that round-bottomed flask is transferred to 72 DEG C is carried out reflux to mention
1.5h is taken, extraction process terminates.Double gauze filtering, obtains extracting solution.Filtrate is transferred to Rotary Evaporators to be concentrated under reduced pressure,
To extract in thick, stopping reduced pressure, third extraction medicinal extract is made.Wherein, the temperature of reduced pressure is 63 DEG C, decompression
The vacuum degree of concentration is -0.08MPa.
It prepares the 4th extraction medicinal extract step: component C being transferred in casserole medicinal cupping, adds 140ml into the casserole medicinal cupping
Pure water (is also required to guarantee water by addition pure water in decoction process), is stirred to be placed on mild fire and decocts
2.5h is stirred continuously or vibrates casserole medicinal cupping in decoction process.After decoction, natural cooling, by the double-deck yarn of decoction liquor
Cloth filtering, filtrate be transferred to Rotary Evaporators be concentrated under reduced pressure into it is thick.Wherein, the temperature of reduced pressure is 85 DEG C, is subtracted
The vacuum degree of pressure concentration is -0.05MPa.
Coated and molded step: medicinal extract, the second extraction medicinal extract, third are extracted by the first of above-mentioned preparation and extracts medicinal extract, the 4th
It extracts medicinal extract and hydrogel is uniformly mixed, wherein the first extraction medicinal extract, the second extraction medicinal extract, third extraction medicinal extract and the 4th mention
It takes the gross weight of medicinal extract and hydrogel weight ratio is 1:4.By above-mentioned uniformly mixed activity extract and hydrogel even spread
In on 30 non-woven fabrics, release paper is covered, the Medical-use cold compress note for improving children's functions of intestines and stomach is made.
Embodiment 3
Material preparation step: the hyacinth bean 50g dried, rhizome of chuanxiong 120g, semen coicis 70g, curcuma zedoary 30g and Rhizoma Gastrodiae 80g constituent component are taken
A takes the Schisandra chinensis 110g dried, fennel seeds 30g, Kadsura Root-bark 460g and leech 120g constituent component B, take the rheum officinale 80g dried,
Borneol 50g and Herba Cistanches 70g constituent component C.Component A, component B and component C are pulverized using grinding machine for Chinese herb medicines, cross 25 mesh
Sieve, it is spare.
Preparation the first extraction medicinal extract step: component A is transferred in round-bottomed flask, 2.5mol/L is added into round-bottomed flask
Ammonium hydroxide 135ml.Round-bottomed flask 1h is shaken with the revolving speed of 120r/min, the mixed liquor in round-bottomed flask is used into double gauze mistake
Filtrate is collected in filter, and filtrate, which is transferred to Rotary Evaporators and be concentrated under reduced pressure into, thick (concentrate wall built-up occurs in evaporative flask
Phenomenon), thickening temperature is 65 DEG C, and vacuum degree is -0.12MPa, is thus made first and extracts medicinal extract.
Preparation the second extraction medicinal extract step: extracting the filter residue collected in medicinal extract step for first and be transferred in round-bottomed flask,
Into round-bottomed flask add 320ml ether be uniformly mixed, round-bottomed flask is transferred in 39 DEG C of thermostat water bath rotated,
Refluxing extraction 3h.After refluxing extraction process, by heating evaporation ether, remaining extract is in medicinal extract shape in round-bottomed flask
If (it is too thick or in bulk, 75% a small amount of ethyl alcohol can be added, reconcile into medicinal extract shape), thus be made second extract leaching
Cream.
Preparation third extracts medicinal extract step: component B being transferred in round-bottomed flask, adds 110ml into the round-bottomed flask
The ethanol solution that mass fraction is 75% is uniformly mixed.The thermostat water bath that round-bottomed flask is transferred to 80 DEG C is carried out reflux to mention
2h is taken, extraction process terminates.Double gauze filtering, obtains extracting solution.Filtrate is transferred to Rotary Evaporators to be concentrated under reduced pressure, until
Third extraction medicinal extract is made in thick, stopping reduced pressure in extract.Wherein, the temperature of reduced pressure is 65 DEG C, is depressurized dense
The vacuum degree of contracting is -0.09MPa.
It prepares the 4th extraction medicinal extract step: component C being transferred in casserole medicinal cupping, adds 160ml into the casserole medicinal cupping
Pure water (is also required to guarantee water by addition pure water in decoction process), is stirred to be placed on mild fire and decocts 2h,
Casserole medicinal cupping is stirred continuously or vibrated in decoction process.After decoction, natural cooling, by decoction liquor double gauze mistake
Filter, filtrate be transferred to Rotary Evaporators be concentrated under reduced pressure into it is thick.Wherein, the temperature of reduced pressure is 82 DEG C, is depressurized dense
The vacuum degree of contracting is -0.07MPa.
Coated and molded step: medicinal extract, the second extraction medicinal extract, third are extracted by the first of above-mentioned preparation and extracts medicinal extract, the 4th
It extracts medicinal extract and hydrogel is uniformly mixed, wherein the first extraction medicinal extract, the second extraction medicinal extract, third extraction medicinal extract and the 4th mention
It takes the gross weight of medicinal extract and hydrogel weight ratio is 1:2.By above-mentioned uniformly mixed activity extract and hydrogel even spread
In on 20 non-woven fabrics, release paper is covered, the Medical-use cold compress note for improving children's functions of intestines and stomach is made.
Embodiment 4
Material preparation step: taking the hyacinth bean 70g dried, rhizome of chuanxiong 80g, semen coicis 80g, curcuma zedoary 20g and Rhizoma Gastrodiae 60g constituent component A,
The Schisandra chinensis 130g dried, fennel seeds 20g, Kadsura Root-bark 480g and leech 80g constituent component B are taken, rheum officinale 100g, the ice dried is taken
Piece 40g and Herba Cistanches 100g constituent component C.Component A, component B and component C are pulverized using grinding machine for Chinese herb medicines, cross 30 mesh
Sieve, it is spare.
Preparation the first extraction medicinal extract step: component A is transferred in round-bottomed flask, 3.5mol/L is added into round-bottomed flask
Ammonium hydroxide 120ml.Round-bottomed flask 2h is shaken with the revolving speed of 120r/min, the mixed liquor in round-bottomed flask is used into double gauze mistake
Filtrate is collected in filter, and filtrate, which is transferred to Rotary Evaporators and be concentrated under reduced pressure into, thick (concentrate wall built-up occurs in evaporative flask
Phenomenon), thickening temperature is 70 DEG C, and vacuum degree is -0.1MPa, is thus made first and extracts medicinal extract.
Preparation the second extraction medicinal extract step: extracting the filter residue collected in medicinal extract step for first and be transferred in round-bottomed flask,
Into round-bottomed flask add 420ml ether be uniformly mixed, round-bottomed flask is transferred in 37 DEG C of thermostat water bath rotated,
Refluxing extraction 2h.After refluxing extraction process, by heating evaporation ether, remaining extract is in medicinal extract shape in round-bottomed flask
If (it is too thick or in bulk, 75% a small amount of ethyl alcohol can be added, reconcile into medicinal extract shape), thus be made second extract leaching
Cream.
Preparation third extracts medicinal extract step: component B being transferred in round-bottomed flask, adds 120ml into the round-bottomed flask
The ethanol solution that mass fraction is 70% is uniformly mixed.The thermostat water bath that round-bottomed flask is transferred to 83 DEG C is carried out reflux to mention
2.5h is taken, extraction process terminates.Double gauze filtering, obtains extracting solution.Filtrate is transferred to Rotary Evaporators to be concentrated under reduced pressure,
To extract in thick, stopping reduced pressure, third extraction medicinal extract is made.Wherein, the temperature of reduced pressure is 68 DEG C, decompression
The vacuum degree of concentration is -0.1MPa.
It prepares the 4th extraction medicinal extract step: component C being transferred in casserole medicinal cupping, adds 180ml into the casserole medicinal cupping
Pure water (is also required to guarantee water by addition pure water in decoction process), is stirred to be placed on mild fire and decocts
1.5h is stirred continuously or vibrates casserole medicinal cupping in decoction process.After decoction, natural cooling, by the double-deck yarn of decoction liquor
Cloth filtering, filtrate be transferred to Rotary Evaporators be concentrated under reduced pressure into it is thick.Wherein, the temperature of reduced pressure is 80 DEG C, is subtracted
The vacuum degree of pressure concentration is -0.09MPa.
Coated and molded step: medicinal extract, the second extraction medicinal extract, third are extracted by the first of above-mentioned preparation and extracts medicinal extract, the 4th
It extracts medicinal extract and hydrogel is uniformly mixed, wherein the first extraction medicinal extract, the second extraction medicinal extract, third extraction medicinal extract and the 4th mention
It takes the gross weight of medicinal extract and hydrogel weight ratio is 1:3.By above-mentioned uniformly mixed activity extract and hydrogel even spread
In on 30 non-woven fabrics, release paper is covered, the Medical-use cold compress note for improving children's functions of intestines and stomach is made.
Embodiment 5
Material preparation step: the hyacinth bean 20g dried, rhizome of chuanxiong 50g, semen coicis 90g, cowherb 50g and Rhizoma Gastrodiae 30g constituent component A are taken, is taken
Schisandra chinensis 60g, fennel seeds 50g, Kadsura Root-bark 560g and the leech 40g constituent component B dried, takes rheum officinale 120g, the borneol dried
80g and Herba Cistanches 120g constituent component C.Component A, component B and component C are pulverized using grinding machine for Chinese herb medicines, cross 40 meshes,
It is spare.
Preparation the first extraction medicinal extract step: component A is transferred in round-bottomed flask, adds 5mol/L's into round-bottomed flask
Ammonium hydroxide 100ml.Round-bottomed flask 1.5h is shaken with the revolving speed of 120r/min, the mixed liquor in round-bottomed flask is used into double gauze mistake
Filtrate is collected in filter, and filtrate, which is transferred to Rotary Evaporators and be concentrated under reduced pressure into, thick (concentrate wall built-up occurs in evaporative flask
Phenomenon), thickening temperature is 75 DEG C, and vacuum degree is -0.08MPa, is thus made first and extracts medicinal extract.
Preparation the second extraction medicinal extract step: extracting the filter residue collected in medicinal extract step for first and be transferred in round-bottomed flask,
Into round-bottomed flask add 500ml ether be uniformly mixed, round-bottomed flask is transferred in 35 DEG C of thermostat water bath rotated,
Refluxing extraction 1.5h.After refluxing extraction process, by heating evaporation ether, remaining extract is in medicinal extract in round-bottomed flask
Shape (if it is too thick or in bulk, 75% a small amount of ethyl alcohol can be added, reconcile into medicinal extract shape), thus be made second extract
Medicinal extract.
Preparation third extracts medicinal extract step: component B being transferred in round-bottomed flask, 80ml matter is added into the round-bottomed flask
The ethanol solution that score is 65% is measured, is uniformly mixed.The thermostat water bath that round-bottomed flask is transferred to 85 DEG C is subjected to refluxing extraction
0.5h, extraction process terminate.Double gauze filtering, obtains extracting solution.Filtrate is transferred to Rotary Evaporators to be concentrated under reduced pressure, until
Third extraction medicinal extract is made in thick, stopping reduced pressure in extract.Wherein, the temperature of reduced pressure is 75 DEG C, is depressurized dense
The vacuum degree of contracting is -0.05MPa.
It prepares the 4th extraction medicinal extract step: component C being transferred in casserole medicinal cupping, adds 220ml into the casserole medicinal cupping
Pure water (is also required to guarantee water by addition pure water in decoction process), is stirred to be placed on mild fire and decocts 1h,
Casserole medicinal cupping is stirred continuously or vibrated in decoction process.After decoction, natural cooling, by decoction liquor double gauze mistake
Filter, filtrate be transferred to Rotary Evaporators be concentrated under reduced pressure into it is thick.Wherein, the temperature of reduced pressure is 75 DEG C, is depressurized dense
The vacuum degree of contracting is -0.12MPa.
Coated and molded step: medicinal extract, the second extraction medicinal extract, third are extracted by the first of above-mentioned preparation and extracts medicinal extract, the 4th
It extracts medicinal extract and hydrogel is uniformly mixed, wherein the first extraction medicinal extract, the second extraction medicinal extract, third extraction medicinal extract and the 4th mention
It takes the gross weight of medicinal extract and hydrogel weight ratio is 1:1.By above-mentioned uniformly mixed activity extract and hydrogel even spread
In on 20 non-woven fabrics, release paper is covered, the Medical-use cold compress note for improving children's functions of intestines and stomach is made.
Effect example
Case selection: 267 Hospitalized Childrens stored selected from April, 2013 in December, 2017, diagnostic criteria foundation " in
State children functions of intestines and stomach abnormity diagnosis therapeutic scheme ".267 infants are randomly divided into two groups, respectively test group 185, the positive
Control group 82.Two groups of children ages are between 2 months to 3 years old, without significant meaning (P in age, gender and clinical manifestation
>0.05)。
Therapeutic scheme: test group infant sticks improvement children's functions of intestines and stomach of the preparation of embodiment 3 at SHENQUE acupoint daily
Medical-use cold compress note one pastes, cleaning skin surface before sticking.Positive controls infant takes orally children's stomach health, and the age was less than 3 months
Each oral 2.5g, twice daily；Infant promotion dosage of the age between 3 months to 1 years old is each to 5g/, twice daily；
Infant of the age greater than 1 years old takes orally 5g every time, three times a day.
Curative effect judgement: effective, times of defecation reduces to 1~2 times/day within 1~3 day, and appearance is normal, and clinical symptoms disappear, stool
Routine inspection is normal；Effectively, 2~3 days times of defecation reduce to 1~2 times/day, and stool moisture disappears substantially, clinical symptoms improve or
Person disappears substantially, and stool routine examination checks that normal or fat globule is a little；In vain, 3 days times of defecation are still greater than 5 times, stool property
Shape is in dilute water egg soup sample, and clinical symptoms are unchanged or aggravate.Before statistics treatment and two groups of infants of after one week treatment are in defecation
On difference, the results are shown in Table 1.
Table 1
By above-mentioned table 1 it is found that compared to being traditionally used for improving drug-children's stomach health of children's functions of intestines and stomach exception,
The Medical-use cold compress note of improvement children's functions of intestines and stomach prepared by embodiment 3 had both had the characteristics that convenient and practical, and using effect is also more excellent,
In particular up to the probability of significant levels will be significantly greater than children's stomach health, and nearly all children is suitble to use.
The times of defecation, stool and feces examination result for counting above-mentioned test group and control group infant restore to normal
Number of days needed for numberical range.
Table 2
* indicate that compared with the control group, experimental group have significant difference (P < 0.05)；* is indicated compared with the control group
Compared with experimental group has extremely significant difference (P < 0.01).
As shown in Table 2, compared to children's stomach health, make the Medical cold prepared with embodiment 3 for improving children's functions of intestines and stomach
It applies and has a clear superiority in terms of being posted on fast quick-recovery times of defecation compared with control group；It is real in terms of fast quick-recovery stool function
The Medical-use cold compress note for applying improvement children's functions of intestines and stomach of the preparation of example 3 is obviously improved compared to children's stomach health, and the time significantly contracts
It is short；On fast quick-recovery stool laboratory indexes, the Medical-use cold compress note of improvement children's functions of intestines and stomach prepared by embodiment 3 is compared to small
Youngster's stomach health has extremely significant promotion, recovery time extremely significant shortening.
The above embodiment is only the preferred embodiment of the present invention, and the scope of protection of the present invention is not limited thereto,
The variation and replacement for any unsubstantiality that those skilled in the art is done on the basis of the present invention belong to institute of the present invention
Claimed range.
Claims (10)
1. a kind of Medical-use cold compress note for improving children's functions of intestines and stomach, which is characterized in that including non-woven fabrics, be coated on non-woven fabrics
Activity extract and hydrogel, and the release paper being bonded with non-woven fabrics；
The activity extract is hyacinth bean, rhizome of chuanxiong, semen coicis, curcuma zedoary, rheum officinale, borneol, fennel seeds, Rhizoma Gastrodiae, Schisandra chinensis, meat desert
The extract of Rong, Kadsura Root-bark and leech；
Weight ratio 1:1~5 of the activity extract and hydrogel.
2. the Medical-use cold compress note according to claim 1 for improving children's functions of intestines and stomach, which is characterized in that by weight,
The hyacinth bean is 2~10 parts, and the rhizome of chuanxiong is 5~20 parts, and the semen coicis is 3~9 parts, and the curcuma zedoary is 1~5 part, described
Rheum officinale is 4~12 parts, and the borneol is 2~8 parts, and the fennel seeds are 1~5 part, and the Rhizoma Gastrodiae is 3~15 parts, the five tastes
Son is 6~16 parts, and the Herba Cistanches are 3~12 parts, and the Kadsura Root-bark is 32~56 parts, and the leech is 4~20 parts.
3. the Medical-use cold compress note according to claim 2 for improving children's functions of intestines and stomach, which is characterized in that by weight,
The hyacinth bean is 3~7 parts, and the rhizome of chuanxiong is 8~15 parts, and the semen coicis is 5~8 parts, and the curcuma zedoary is 2~4 parts, described big
Huang is 6~10 parts, and the borneol is 4~6 parts, and the fennel seeds are 2~4 parts, and the Rhizoma Gastrodiae is 6~10 parts, the Schisandra chinensis
It is 8~13 parts, the Herba Cistanches are 5~10 parts, and the Kadsura Root-bark is 40~48 parts, and the leech is 8~15 parts.
4. the Medical-use cold compress note according to claim 3 for improving children's functions of intestines and stomach, which is characterized in that by weight,
The hyacinth bean is 5 parts, and the rhizome of chuanxiong is 12 parts, and the semen coicis is 7 parts, and the curcuma zedoary is 3 parts, and the rheum officinale is 8 parts, described
Borneol is 5 parts, and the fennel seeds are 3 parts, and the Rhizoma Gastrodiae is 8 parts, and the Schisandra chinensis is 11 parts, and the Herba Cistanches are 7 parts, described
Kadsura Root-bark is 46 parts, and the leech is 12 parts.
5. the preparation method of the Medical-use cold compress note according to claim 1-4 for improving children's functions of intestines and stomach, special
Sign is, includes the following steps,
Stock: hyacinth bean, rhizome of chuanxiong, semen coicis, curcuma zedoary and Rhizoma Gastrodiae constituent component A are taken, Schisandra chinensis, fennel seeds, Kadsura Root-bark and leech are taken
Constituent component B takes rheum officinale, borneol and Herba Cistanches constituent component C, component A, B and C is pulverized, and crosses 10~40 meshes；
Medicinal extract is extracted in preparation first: Xiang Zufen A adds 100~200 parts of ammonium hydroxide of 1~5mol/L, impregnates 0.5~2.5h, filter,
Collect filtrate, filtrate be transferred to Rotary Evaporators be concentrated under reduced pressure into it is thick, thickening temperature be 55~75 DEG C, vacuum degree
For -0.08~-0.16MPa, it is made first and extracts medicinal extract；
Medicinal extract is extracted in preparation second: adding 200~500 parts of ether in the filter residue of Xiang Zufen A after filtering and carries out refluxing extraction 1.5
~4.5h, Extracting temperature are 35~45 DEG C, separate ether and extract, are made second and extract medicinal extract；
Preparation third extracts medicinal extract: adding to flow back mentioning in Xiang Zufen B at 80~150 parts of ethyl alcohol, 70~85 DEG C of 60%~80%
Take 0.5~3h, filtering, filtrate is transferred to Rotary Evaporators and be concentrated under reduced pressure into thick, and thickening temperature is 55~75 DEG C, very
Reciprocal of duty cycle is -0.05~-0.12MPa, and third is made and extracts medicinal extract；
It prepares the 4th extraction medicinal extract: adding 100~220 parts of pure water in Xiang Zufen C, decoct 1~3.5h, decoction liquor is transferred to
Rotary Evaporators be concentrated under reduced pressure into it is thick, thickening temperature be 75~95 DEG C, vacuum degree be -0.02~-0.12MPa, system
It obtains the 4th and extracts medicinal extract；
Coated and molded: medicinal extract, the second extraction medicinal extract, third are extracted by first and extracts medicinal extract, the 4th extraction medicinal extract and hydrogel and mixes
It closes uniformly, is spread evenly across on non-woven fabrics, be bonded release paper, the Medical-use cold compress note for improving children's functions of intestines and stomach is made.
6. the preparation method of the Medical-use cold compress note according to claim 5 for improving children's functions of intestines and stomach, which is characterized in that
Preparation first is extracted in medicinal extract step, and the dosage of ammonium hydroxide is 120~150 parts, and the concentration of ammonium hydroxide is 2~3.5mol/L, when immersion
Between be 1.5h, thickening temperature be 65 DEG C, vacuum degree be -0.1MPa.
7. the preparation method of the Medical-use cold compress note according to claim 5 for improving children's functions of intestines and stomach, which is characterized in that
Preparation second is extracted in medicinal extract step, and ether dosage is 320 parts, reflux extracting time 3h, and Extracting temperature is 39 DEG C.
8. the preparation method of the Medical-use cold compress note according to claim 5 for improving children's functions of intestines and stomach, which is characterized in that
It prepares third to extract in medicinal extract step, the dosage of 75% ethyl alcohol is 100~120 parts, and refluxing extraction temperature is 80 DEG C, and reflux mentions
Taking the time is 1.5~2.5h, and thickening temperature is 63~68 DEG C, and vacuum degree is -0.08~-0.1MPa.
9. the preparation method of the Medical-use cold compress note according to claim 5 for improving children's functions of intestines and stomach, which is characterized in that
It prepares in the 4th extraction medicinal extract step, the dosage of pure water is 140~180 parts, and decocting time is 1.5~2.5h, thickening temperature
It is 80~85 DEG C, vacuum degree is -0.05~-0.09MPa.
10. the preparation method of the Medical-use cold compress note according to claim 5 for improving children's functions of intestines and stomach, which is characterized in that
In coated and molded step, by weight, first, which extracts medicinal extract, the second extraction medicinal extract, third, extracts medicinal extract and the 4th extraction
The ratio between the summation of medicinal extract and hydrogel are 1:2.
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| CN102430009A (en) * | 2008-12-24 | 2012-05-02 | 天津中新药业集团股份有限公司乐仁堂制药厂 | Traditional Chinese medicinal composition for treating gastrointestinal disease and preparation method thereof |
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2018
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| CN102430009A (en) * | 2008-12-24 | 2012-05-02 | 天津中新药业集团股份有限公司乐仁堂制药厂 | Traditional Chinese medicinal composition for treating gastrointestinal disease and preparation method thereof |
| CN103405743A (en) * | 2013-08-23 | 2013-11-27 | 尹永红 | Drug preparation for infantile diarrhea |
| CN204581655U (en) * | 2015-01-12 | 2015-08-26 | 杭州济迩斯生物科技有限公司 | Medical cold is applied ointment or plaster |
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Application publication date: 20190301 |