CN104399040A - Drug for treating gastrectasia and preparation method thereof - Google Patents
Drug for treating gastrectasia and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a drug for treating gastrectasia and a preparation method thereof. The drug is prepared from bighead atractylodes rhizome, pinellia ternate, endothelium corneum gigeriae galli, raw yam, rhizoma zingiberis, reddle, radices paeoniae alba, mangnolia officinalis and ginger by combination, can invigorate the spleen, supplement qi, eliminate dampness, induce diuresis, invigorate the spleen and the stomach, promote salivation, benefit lung, reinforce kidneys, arrest seminal emission, accelerate peristalsis hyperfunction, invigorate qi, benefit blood, regulate the blood qi, soothe liver of people, remove liver deficiency fire, relieve pain, diminish inflammation, promote the circulation of qi and remove qi stagnation, dry dampness, eliminate fullness, appetize and strengthen spleen, promote appetite and treat dyspepsia, has an exact curative effect of treating stomach duct pain, nausea, emesis, aphagosis and the like and has no side effects.
Description
Technical field
The present invention relates to a kind of is Chinese medicine composition of crude drug and preparation method thereof by Chinese herbal medicine, relates to a kind of medicine for the treatment of flatulence and preparation method thereof specifically.
Background technology
Flatulence refers to that patient feels that gastral cavilty support is swollen, and outward appearance has again a kind of disease of the morphologic appearance of distension, can simultaneously with gastralgia, Nausea and vomiting, the clinical manifestation such as can not to take food.Flatulence is generally glutted after meal, belch, and uneasy in either sitting or lying, has lost all desire for food and drink; The repeatability of flatulence and chronicity can cause gastritis, digestive tract ulcer, even can develop into gastric cancer.Western medicine flatulence adopts usually accelerates the Drug therapy of enterokinesia, can only shor time treatment flatulence, can only take stopgap measures and can not effect a permanent cure, and side effect is larger.And Western medicine is as reached happiness in treatment flatulence mostly, patient can not drink water.
Summary of the invention
The present invention, from clinical treatment medication demand and the dialectical principle of traditional Chinese medical science prescription, proposes a kind of medicine for the treatment of flatulence and preparation method thereof.It is the medicament be prepared from by the crude drug of following parts by weight proportioning: Rhizoma Atractylodis Macrocephalae 3-15g, Rhizoma Pinelliae 3-8g, Endothelium Corneum Gigeriae Galli 3-9g, Rhizoma Dioscoreae 7-13g, Rhizoma Zingiberis 2-5g, Haematitum 9-15g, Radix Paeoniae Alba 3-9g, Cortex Magnoliae Officinalis 3-9g, Rhizoma Zingiberis Recens 3-9g.Optimum ratio is: Rhizoma Atractylodis Macrocephalae 12g, Rhizoma Pinelliae 5g, Endothelium Corneum Gigeriae Galli 6g, Rhizoma Dioscoreae 10g, Rhizoma Zingiberis 3g, Haematitum 12g, Radix Paeoniae Alba 6g, Cortex Magnoliae Officinalis 6g, Rhizoma Zingiberis Recens 6g.Described medicament is decoction, capsule, tablet or pill.
The preparation method step of described capsule, tablet, pill is as follows:
(1) in the side of getting, screen analysis pulverized by the Rhizoma Atractylodis Macrocephalae, the Rhizoma Pinelliae, Endothelium Corneum Gigeriae Galli, Rhizoma Dioscoreae, Rhizoma Zingiberis, Haematitum, the Radix Paeoniae Alba, Cortex Magnoliae Officinalis, Rhizoma Zingiberis Recens;
(2) decocted with water 2-3 time by the mixture of sieve series in step (1), collecting decoction, filtration, worry liquid is condensed into 70-80 when spending, capsule, pill relative density are the thick paste of 1.0-1.6, and tablet relative density is the thick paste of 1.0-1.4;
(3) when making capsule, pill:
By thick paste separation and purification, drying, make dry granule; By dry for step granule mix homogeneously, in filled capsules, namely make capsule; Dry granule spray is added refined honey, mix homogeneously, makes piller and namely make pill;
When making tablet:
2-4 part starch is mixed homogeneously with the thick paste in step (2), makes granule, drying, make dry granule, dry granule is pressed into tablet, sugar coating, namely makes tablet.
Mixture described in step (2), the preferred number of times decocted with water is 2 times, and first time is 60-80 minute, and second time is 40-60 minute.
the pharmacology of medicine material medicine of the present invention is as follows:
The Rhizoma Atractylodis Macrocephalae: there is invigorating the spleen and benefiting QI, dampness diuretic, antiperspirant efficacy, for insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema;
The Rhizoma Pinelliae: there is drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass effect, for vomitting regurgitation, breast gastral cavity painful abdominal mass is vexed;
Endothelium Corneum Gigeriae Galli: for dyspepsia;
Rhizoma Dioscoreae: there is spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, effect of the kidney invigorating arresting seminal emission, breathes with cough, deficiency-heat quenches one's thirst for insufficiency of the spleen lack of appetite, chronic diarrhea not less than, the deficiency of the lung;
Rhizoma Zingiberis: acrid in the mouth, hot in nature.Return spleen, stomach, the heart, lung meridian, cure mainly coldness and pain in the epigastrium, vomit, have loose bowels, YANG-depletion faint inverse, cold fluid-retention is breathed with cough, arthralgia due to cold-dampnes;
Haematitum: nature and flavor, bitter sweet; Flat, be included into liver, stomach, heart born of the same parents warp; Modern medicine confirms, enterokinesia can be made hyperfunction, also have appreciable stimulating action to small intestinal;
The Radix Paeoniae Alba: have invigorating qi and benefiting blood, nourish conditioning vim and vigour, liver's asthenic fire is calmed down by the liver of dredging people, analgesic antiphlogistic, has therapeutical effect well to the cloudy gas of human body especially women.
Cortex Magnoliae Officinalis: there is circulation of qi promoting removing food stagnancy, dampness is except full, and lowering the adverse QI to relieve asthma effect, has therapeutical effect to diseases such as stagnation of QI due to dyspepsia, abdominal distention constipation, retention of dampness in middle-JIAO;
Rhizoma Zingiberis Recens: have disperse, preventing or arresting vomiting, cough-relieving, appetite promoting and the spleen strengthening, promote the effect such as appetite, its effective ingredient is zingiberene, has the effect of protection Gastric Mucosal Cells.
The present invention is with the Rhizoma Atractylodis Macrocephalae, Haematitum for monarch drug, and for invigorating the spleen and benefiting QI, dampness diuretic, accelerates enterokinesia hyperfunction; With Rhizoma Dioscoreae, the Radix Paeoniae Alba, Cortex Magnoliae Officinalis, Rhizoma Zingiberis Recens, Endothelium Corneum Gigeriae Galli for ministerial drug, spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission, invigorating qi and benefiting blood, nourish conditioning vim and vigour, liver's asthenic fire is calmed down by the liver of dredging people, analgesic antiphlogistic, circulation of qi promoting removing food stagnancy, dampness is except full, and appetite promoting and the spleen strengthening, promotes appetite, dyspepsia; Assistant, with the Rhizoma Pinelliae, makes with Rhizoma Zingiberis, drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass, coldness and pain in the epigastrium, vomiting.Medicine of the present invention holds the marrow of the traditional Chinese medical science, rigorous prescription, and all medicine monarch share, and mends broken combination, brings out the best in each other, meet the principle of traditional Chinese medical science medicine law and determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs.
beneficial effect
Chinese medicine composition of the present invention can invigorating the spleen and benefiting QI, dampness diuretic, spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission, accelerates enterokinesia hyperfunction, invigorating qi and benefiting blood, nourish conditioning vim and vigour, liver's asthenic fire is calmed down by the liver of dredging people, analgesic antiphlogistic, circulation of qi promoting removing food stagnancy, dampness is removed full, appetite promoting and the spleen strengthening, promote appetite, treatment dyspepsia, has special efficacy to treatment gastralgia, Nausea and vomiting, can not take food etc., and has no side effect.
Acute toxicity test: larger dose and take to the growth of rat without remarkable toxicity compared with long-term therapy, have no overt toxicity damage to the chip form inspection such as brain, the heart, liver, kidney of rat and change, test display, this drug toxicity is very little.
clinical trial:
select case
Clinical gastralgia, Nausea and vomiting patient 223 example, 37 years old mean age.
diagnostic criteria
Gastralgia, Nausea and vomiting, can not to take food.
Therapeutic scheme
Embodiment 2 capsule, each 4, every 0.3g, morning, noon and afternoon one after each meal 3 days is a course for the treatment of, takes 2 courses for the treatment of.
the standard of curative effect evaluation
Recovery from illness: stomachache, Nausea and vomiting transference cure, had appetite, without recurrence in 3 months;
Effective: stomachache, Nausea and vomiting slow down; But do not disappear;
Invalid: stomachache, Nausea and vomiting symptom is unchanged;
Total effective rate=cure rate+effective percentage.
data statistics
| Case load | Recovery from illness | Effectively | Invalid | Cure rate | Total effective rate |
| 223 examples | 211 | 12 | 0 | 94.62% | 100.00% |
conclusion
In clinical 223 routine cases, after 1-2 the course for the treatment of of taking medicine continuously, 211 example recoveries from illness, stomachache, Nausea and vomiting transference cure, have appetite, and follow up a case by regular visits to without recurrence in 3 months, cure rate reaches 94.62; Effective 12 examples, stomach pain, Nausea and vomiting symptom slow down, and invalid 0 example, total effective rate reaches 100%.Above-mentioned clinical data reflects, and Chinese medicine composition of the present invention can invigorating the spleen and benefiting QI, dampness diuretic, spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission, acceleration enterokinesia is hyperfunction, invigorating qi and benefiting blood, nourishes conditioning vim and vigour, and liver's asthenic fire is calmed down by the liver of dredging people, analgesic antiphlogistic, circulation of qi promoting removing food stagnancy, dampness is except full, appetite promoting and the spleen strengthening, promotes appetite, treatment dyspepsia, there is special efficacy to treatment gastralgia, Nausea and vomiting, can not take food etc., and have no side effect.
Detailed description of the invention
embodiment 1:a kind of medicine for the treatment of flatulence and preparation method thereof.It is the medicament be prepared from by the crude drug of following parts by weight proportioning: Rhizoma Atractylodis Macrocephalae 3-15g, Rhizoma Pinelliae 3-8g, Endothelium Corneum Gigeriae Galli 3-9g, Rhizoma Dioscoreae 7-13g, Rhizoma Zingiberis 2-5g, Haematitum 9-15g, Radix Paeoniae Alba 3-9g, Cortex Magnoliae Officinalis 3-9g, Rhizoma Zingiberis Recens 3-9g.Described medicament is capsule, tablet or pill.
According to following portions by weight proportioning weighting raw materials:
Rhizoma Atractylodis Macrocephalae 3-15g, Rhizoma Pinelliae 3-8g, Endothelium Corneum Gigeriae Galli 3-9g, Rhizoma Dioscoreae 7-13g, Rhizoma Zingiberis 2-5g, Haematitum 9-15g, Radix Paeoniae Alba 3-9g, Cortex Magnoliae Officinalis 3-9g, Rhizoma Zingiberis Recens 3-9g.
The preparation method step of described capsule, tablet, pill is as follows:
(1) in the side of getting, screen analysis pulverized by the Rhizoma Atractylodis Macrocephalae, the Rhizoma Pinelliae, Endothelium Corneum Gigeriae Galli, Rhizoma Dioscoreae, Rhizoma Zingiberis, Haematitum, the Radix Paeoniae Alba, Cortex Magnoliae Officinalis, Rhizoma Zingiberis Recens;
(2) decocted with water 2-3 time by the mixture of sieve series in step (1), collecting decoction, filtration, worry liquid is condensed into 70-80 when spending, capsule, pill relative density are the thick paste of 1.0-1.6, and tablet relative density is the thick paste of 1.0-1.4;
(3) when making capsule, pill:
By thick paste separation and purification, drying, make dry granule; By dry for step granule mix homogeneously, in filled capsules, namely make capsule; Dry granule spray is added refined honey, mix homogeneously, makes piller and namely make pill;
When making tablet:
2-4 part starch is mixed homogeneously with the thick paste in step (2), makes granule, drying, make dry granule, dry granule is pressed into tablet, sugar coating, namely makes tablet.
Mixture described in step (2), the preferred number of times decocted with water is 2 times, and first time is 60-80 minute, and second time is 40-60 minute.
embodiment 2:a kind of medicine for the treatment of flatulence and preparation method thereof.It is the medicament be prepared from by the crude drug of following parts by weight proportioning: Rhizoma Atractylodis Macrocephalae 12g, Rhizoma Pinelliae 5g, Endothelium Corneum Gigeriae Galli 6g, Rhizoma Dioscoreae 10g, Rhizoma Zingiberis 3g, Haematitum 12g, Radix Paeoniae Alba 6g, Cortex Magnoliae Officinalis 6g, Rhizoma Zingiberis Recens 6g.Described medicament is capsule, tablet or pill.
According to following portions by weight proportioning weighting raw materials:
Rhizoma Atractylodis Macrocephalae 12g, Rhizoma Pinelliae 5g, Endothelium Corneum Gigeriae Galli 6g, Rhizoma Dioscoreae 10g, Rhizoma Zingiberis 3g, Haematitum 12g, Radix Paeoniae Alba 6g, Cortex Magnoliae Officinalis 6g, Rhizoma Zingiberis Recens 6g.
The preparation method step of described capsule, tablet, pill is as follows:
(1) in the side of getting, screen analysis pulverized by the Rhizoma Atractylodis Macrocephalae, the Rhizoma Pinelliae, Endothelium Corneum Gigeriae Galli, Rhizoma Dioscoreae, Rhizoma Zingiberis, Haematitum, the Radix Paeoniae Alba, Cortex Magnoliae Officinalis, Rhizoma Zingiberis Recens;
(2) decocted with water 2-3 time by the mixture of sieve series in step (1), collecting decoction, filtration, worry liquid is condensed into 70-80 when spending, capsule, pill relative density are the thick paste of 1.0-1.6, and tablet relative density is the thick paste of 1.0-1.4;
(3) when making capsule, pill:
By thick paste separation and purification, drying, make dry granule; By dry for step granule mix homogeneously, in filled capsules, namely make capsule; Dry granule spray is added refined honey, mix homogeneously, makes piller and namely make pill;
When making tablet:
2-4 part starch is mixed homogeneously with the thick paste in step (2), makes granule, drying, make dry granule, dry granule is pressed into tablet, sugar coating, namely makes tablet.
Mixture described in step (2), the preferred number of times decocted with water is 2 times, and first time is 60-80 minute, and second time is 40-60 minute.
Embodiment 3: medicine of the present invention can also be decoction, oral liquid, granule etc.
Claims (5)
1. treat a medicine for flatulence, it is characterized in that it is the medicament be prepared from by the crude drug of following parts by weight proportioning: Rhizoma Atractylodis Macrocephalae 3-15g, Rhizoma Pinelliae 3-8g, Endothelium Corneum Gigeriae Galli 3-9g, Rhizoma Dioscoreae 7-13g, Rhizoma Zingiberis 2-5g, Haematitum 9-15g, Radix Paeoniae Alba 3-9g, Cortex Magnoliae Officinalis 3-9g, Rhizoma Zingiberis Recens 3-9g.
2. the medicine for the treatment of flatulence according to claim 1, is characterized in that it is the medicament be prepared from by the crude drug of following parts by weight proportioning: Rhizoma Atractylodis Macrocephalae 12g, Rhizoma Pinelliae 5g, Endothelium Corneum Gigeriae Galli 6g, Rhizoma Dioscoreae 10g, Rhizoma Zingiberis 3g, Haematitum 12g, Radix Paeoniae Alba 6g, Cortex Magnoliae Officinalis 6g, Rhizoma Zingiberis Recens 6g.
3. the medicine for the treatment of flatulence according to claim 1 and 2, is characterized in that: described medicament is decoction, capsule, tablet or pill.
4. the medicine for the treatment of flatulence according to claim 3, is characterized in that: the preparation method step of described capsule, tablet, pill is as follows:
(1) in the side of getting, screen analysis pulverized by the Rhizoma Atractylodis Macrocephalae, the Rhizoma Pinelliae, Endothelium Corneum Gigeriae Galli, Rhizoma Dioscoreae, Rhizoma Zingiberis, Haematitum, the Radix Paeoniae Alba, Cortex Magnoliae Officinalis, Rhizoma Zingiberis Recens;
(2) decocted with water 2-3 time by the mixture of sieve series in step (1), collecting decoction, filtration, worry liquid is condensed into 70-80 when spending, capsule, pill relative density are the thick paste of 1.0-1.6, and tablet relative density is the thick paste of 1.0-1.4;
(3) when making capsule, pill:
By thick paste separation and purification, drying, make dry granule; By dry for step granule mix homogeneously, in filled capsules, namely make capsule; Dry granule spray is added refined honey, mix homogeneously, makes piller and namely make pill;
When making tablet:
2-4 part starch is mixed homogeneously with the thick paste in step (2), makes granule, drying, make dry granule, dry granule is pressed into tablet, sugar coating, namely makes tablet.
5. the preparation method of the medicine for the treatment of flatulence according to claim 4, is characterized in that the mixture described in step (2), and the number of times decocted with water is 2 times, and first time is 60-80 minute, and second time is 40-60 minute.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105168709A (en) * | 2015-08-21 | 2015-12-23 | 霍传生 | Traditional Chinese medicine composition for treating stomach distension |
| CN105435072A (en) * | 2015-12-25 | 2016-03-30 | 梁献彬 | Method for preparing gasteremphraxis-eliminating oral solution |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103536753A (en) * | 2013-09-28 | 2014-01-29 | 王纯治 | Traditional Chinese medicine mixture for treating chronic gastroenteritis |
| CN103800611A (en) * | 2012-11-20 | 2014-05-21 | 李永胜 | Granules and powder for treating chronic gastritis and gastric ulcer |
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2014
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| CN105168709A (en) * | 2015-08-21 | 2015-12-23 | 霍传生 | Traditional Chinese medicine composition for treating stomach distension |
| CN105435072A (en) * | 2015-12-25 | 2016-03-30 | 梁献彬 | Method for preparing gasteremphraxis-eliminating oral solution |
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