CN103920114A

CN103920114A - Traditional Chinese medicinal composition for treating pulmonary fibrosis

Info

Publication number: CN103920114A
Application number: CN201410138995.8A
Authority: CN
Inventors: 李树民; 苏俊红; 于惠玲; 沈辉; 何秀玉
Original assignee: 李树民
Current assignee: Jiamusi University
Priority date: 2014-03-31
Filing date: 2014-03-31
Publication date: 2014-07-16
Anticipated expiration: 2034-03-31
Also published as: CN103920114B

Abstract

The invention discloses a traditional Chinese medicinal composition for treating pulmonary fibrosis, and belongs to the technical field of a traditional Chinese medicine. The traditional Chinese medicinal composition is characterized by being prepared into a gastrointestinal-delivery dosage form from the following traditional Chinese medicinal raw materials by weight: 15-20g of codonopsis pilosula, 15-20g of fruits of Chinese magnoliavine, 15-20g of trichosanthes kirilowii maxim, 15-20g of radix ophiopogonis, 10-12g of rhizoma pinellinae praeparata, 10-12g of radix trichosanthis, 10-12g of thunberg fritillary bulb, 10-12g of cassia twig, 10-12g of nutgrass galingale rhizome, 6-9g of scutellaria baicalensis, 6-9g of dried ginger and 6-9g of honey-fried liquorice. The traditional Chinese medicinal composition disclosed by the invention can significantly improve such symptoms caused by pulmonary fibrosis as chest distress, shortness of breath, chronic cough and gasp syndrome, and can improve pulmonary functions of patients remarkably after long-term use.

Description

A kind of Chinese medicine composition for the treatment of pulmonary fibrosis

Technical field

The present invention relates to a kind of Chinese medicine composition for the treatment of pulmonary fibrosis, belong to technical field of Chinese medicines.

Background technology

Pulmonary fibrosis be one group with the disease that interstitial lung diffusivity is oozed out, infiltration and fiber turn to major lesions, comprise idiopathic pulmonary fibrosis and Secondary cases pulmonary fibrosis, cardinal symptom is carrying out property dyspnea, finally causes respiratory failure and wishes.Its cause of disease complexity, poor prognosis, lacks effective treatment means clinically, is classified as refractory disease by World Health Organization (WHO).In recent years, Chinese traditional treatment pulmonary fibrosis comes into one's own day by day, and receives satisfactory effect.

Applicant retrieves prior art for Chinese traditional treatment pulmonary fibrosis, is now summarized as follows:

1. retrieve in Chinese patent database taking " pulmonary fibrosis " as key word, the number of patent application relating to has: 200410016139.1, 200610020716.3, 201310466775.3, 200410093218.2, 201110162621.6, 200710062958.3, 201110162761.3, 201210323169.1, 200810146820.6, 201010531346.6, 200810226292.5, 201110244047.9, 200910172434.9, 200910172430.0, 201210046990.3, 201110322037.2, 200810103844.3, 201110109179.0, 200410041132.5.Applicant analyzes relating to Chinese medicine formula in above-mentioned patent, does not find and the similar Chinese prescription of the present invention.

2. retrieve at Chinese periodical paper database taking " pulmonary fibrosis " as key word.

" Treatment Pulmonary F ibrosis by Chinese Herbs progress " (Zhang Juan, Yan Yongjian " Shandong Traditional Chinese Medicine University's journal " the 33rd the 1st phase of volume of January in 2009) summarized the progress of Chinese medicine pulmonary fibrosis in nearly 10 years.

" literature research of modern Chinese medicine treatment idiopathic pulmonary fibrosis " (quiet 2012 Shandong Traditional Chinese Medicine University's Master's thesis of State of Zhao) is in conjunction with modern statistics method, the angle using from square medicine, has carried out the frequency, frequency analysis to the square medicine of idiopathic pulmonary fibrosis.The Chinese medicine frequency of usage relating to is as follows:

Above-mentioned data searching is quoted at this as prior art.

Summary of the invention

The invention provides a kind of Chinese medicine composition for the treatment of pulmonary fibrosis, to pulmonary fibrosis cause uncomfortable in chest, breathe hard, the symptom such as chronic cough, the syndrome of dyspnea improves obviously, long-term taking can obviously improve Pulmonary Function.

The concrete technical scheme adopting of the present invention is:

A Chinese medicine composition for the treatment of pulmonary fibrosis, is characterized in that, is made up the dosage form of intestines and stomach administration of the raw material of Chinese medicine of following part by weight:

Radix Codonopsis, Fructus Schisandrae Chinensis, Semen Trichosanthis, Radix Ophiopogonis each 15-20g

Rhizoma Pinelliae Preparatum, Radix Trichosanthis, Bulbus Fritillariae Thunbergii, Ramulus Cinnamomi, the each 10-12g of Rhizoma Cyperi;

Radix Scutellariae, Rhizoma Zingiberis, the each 6-9g of Radix Glycyrrhizae Preparata.

The preferred dosage form of the present invention is: decoction, mixture, syrup, electuary, capsule.Described dosage form is prepared according to prior art, wherein also comprises necessary adjuvant.

In the present invention, adopt the latin name of raw material of Chinese medicine as follows:

Radix Scutellariae RADIX SCUTELLARIAE, Radix Codonopsis RADIX CODONOPSIS, Rhizoma Pinelliae Preparatum RHIZOMAPINELLIAE, Radix Trichosanthis RADIX TRICHOSANTHIS, Ramulus Cinnamomi RAMULUS CINNAMOMI, Fructus Schisandrae Chinensis FRUCTUS SCHISANDRAE CHINENSIS, Rhizoma Zingiberis RHIZOMA ZINGIBERIS, Semen Trichosanthis SEMEN TRICHOSANTHIS, Rhizoma Cyperi RHIZOMA CYPERI, Radix Glycyrrhizae Preparata RADIXGLYCYRRHIZAE, Bulbus Fritillariae Thunbergii BULBUS FRITILLARIAE THUNBERGII, Radix Ophiopogonis RADIXOPHIOPOGONIS.

The nature and flavor of the Chinese medicinal components adopting in the present invention with return through, function and cure mainly as follows:

Radix Scutellariae

[nature and flavor with return footpath] hardship, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian.

[function with cure mainly] heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.For hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood is told nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.

Radix Codonopsis

[nature and flavor with return through] are sweet, flat.Return spleen, lung meridian.

[function with cure mainly] invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, the cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency cough, interior-heat is quenched one's thirst.

Rhizoma Pinelliae Preparatum

[nature and flavor with return through] are pungent, temperature; Poisonous.Return spleen, stomach, lung meridian.

[function with cure mainly] drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.For abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm headache, vomiting regurgitation, breast gastral cavity painful abdominal mass is vexed, globus hystericus; Raw with external treatment carbuncle sucutaneous nodule.Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) is used for stopping nausea and vomiting by lowering the adverse flow of QI.

Radix Trichosanthis

[nature and flavor with return through] sweet, micro-hardship, is slightly cold.Attach to the lung and stomach meridians.

[function with cure mainly] clearing away heat and promoting production of body fluid, detumescence and apocenosis.For calentura excessive thirst, lung-heat type cough, interior-heat is quenched one's thirst, sore swollen toxin.

Ramulus Cinnamomi

[nature and flavor with return through] acrid, sweet, warm.GUIXIN, lung, urinary bladder channel.

[function with cure mainly] diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.

Fructus Schisandrae Chinensis

[nature and flavor with return through] acid, sweet, temperature.Return lung, the heart, kidney channel.

[function with cure mainly] restrains astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, the deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.

Rhizoma Zingiberis

[nature and flavor with return through] are pungent, hot.Return spleen, stomach, kidney, the heart, lung meridian.

[function with cure mainly] Rhizoma Zingiberis warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, dampness expectorant.For coldness and pain in the epigastrium, vomiting is had loose bowels, cold extremities faint pulse, and phlegm retention is breathed with cough.

Semen Trichosanthis

[nature and flavor with return through] are sweet, cold.Return lung, stomach, large intestine channel.

[function with cure mainly] moistening the lung and resolving phlegm, laxation relieving constipation.Glutinous for cough caused by dryness expectorant, dryness of the intestine constipation.Rhizoma Cyperi Radix Glycyrrhizae Preparata

[nature and flavor with return through] are sweet, flat.GUIXIN, lung, spleen, stomach warp.

[function with cure mainly] invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.

Bulbus Fritillariae Thunbergii

[nature and flavor with return through] hardship, cold.Return lung, heart channel.

[function with cure mainly] heat clearing away eliminating stagnation, preventing phlegm from forming and stopping coughing, for wind-heat invading the lung, phlegm-fire cough, lung abscess, acute mastitis, scrofula, sore.

Radix Ophiopogonis

[nature and flavor with return through] are sweet, and micro-hardship, is slightly cold.GUIXIN, lung, stomach warp.

[function with cure mainly] YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.For dryness of the lung dry cough.Chronic consumptive disease cough, Tianjin wound is thirsty, vexed insomnia, interior-heat is quenched one's thirst, dryness of the intestine constipation; Pharyngeal diphtheria.

Below further set forth beneficial effect of the present invention by clinical observation on the therapeutic effect, concrete case.

One, clinical observation on the therapeutic effect test

1. clinical data

Select 2004～2012 patient's 35 examples, wherein male 20 examples, female's 15 examples, 45～65 years old age, average 54.2 years old.Patient derives from applicant place hospital.

2 treatment and methods

Radix Scutellariae 9g, Radix Codonopsis 15g, Rhizoma Pinelliae Preparatum 12g, Radix Trichosanthis 12g, Ramulus Cinnamomi 12g, Fructus Schisandrae Chinensis 15g, Rhizoma Zingiberis 6g, Semen Trichosanthis 15g, Rhizoma Cyperi 12g, Radix Glycyrrhizae Preparata 6g, Bulbus Fritillariae Thunbergii 12g, Radix Ophiopogonis 15g.Get the prepared slices of Chinese crude drugs of each raw material, above-mentioned consumption is potion consumption, is cooked into decoction with decocting.

Take two doses every day, noon, evening, respectively once every 5 days was a course for the treatment of.Take continuously two courses for the treatment of.

3. clinical observation is summed up

Through clinical observation, 88.5% patient continued to take medicine after the course for the treatment of, uncomfortable in chest, breathe hard, cough, asthma symptom alleviate; 97.1% the patient symptom after two courses for the treatment of that continues to take medicine obviously alleviates.

Two, medical record for example

1. Lee X, man, 60 years old.When medical, private prosecution is suffered from pulmonary fibrosis and is had half a year, within nearly one week, carrys out chest and extremely feels oppressed, and tells white sticky expectorant, and night, asthma was acute, and sweating due to debility is many, and chronic cough is more than.Take medicine after the course for the treatment of, symptom alleviates, and can put down night and crouch, and adheres to taking two courses for the treatment of, and all symptoms obviously alleviate.

2. high XX, female, 46 years old.When first visit, x-ray is diagnosed as pulmonary fibrosis, and private prosecution is breathed with cough incessantly recently, and can not lie flat night, and cushion is slept less, the cardiopalmus of breathing hard, and movable rear aggravation, abundant expectoration, takes repeatly Chinese medicine and western medicine and does not imitate.Enlarged tongue, limit has tooth to print, floating and tense pulse.Take medicine two courses for the treatment of, symptom alleviates.

Detailed description of the invention

Embodiment

Claims

1. a Chinese medicine composition for the treatment of pulmonary fibrosis, is characterized in that, is made up the dosage form of intestines and stomach administration of the raw material of Chinese medicine of following part by weight:

Radix Codonopsis, Fructus Schisandrae Chinensis, Semen Trichosanthis, Radix Ophiopogonis each 15-20g; Rhizoma Pinelliae Preparatum, Radix Trichosanthis, Bulbus Fritillariae Thunbergii, Ramulus Cinnamomi, the each 10-12g of Rhizoma Cyperi; Radix Scutellariae, Rhizoma Zingiberis, the each 6-9g of Radix Glycyrrhizae Preparata.

2. the Chinese medicine composition for the treatment of pulmonary fibrosis according to claim 1, is characterized in that, the dosage form of described Chinese medicine composition is decoction, mixture, syrup, electuary or capsule.