CN109091609A - A kind of Chinese medicine composition and preparation method thereof with anti-oxidant blood fat reducing function - Google Patents
A kind of Chinese medicine composition and preparation method thereof with anti-oxidant blood fat reducing function Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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- A61K36/88—Liliopsida (monocotyledons)
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Abstract
The invention discloses a kind of Chinese medicine composition and preparation method thereof with anti-oxidant blood fat reducing function, the polysaccharide composition includes: Baical Skullcap root P.E, peony root extractive, ophiopogon japonicus extract, Magnolia cortex P.E, loquat-leaf extract, Megranate Seed P.E, safflower extract, perilla leaf extract, gives full play to its synergistic effect by different ratio combination.It is obtained by zoopery, Chinese medicine composition prepared by the present invention can effectively remove free radical, and have significant blood fat reducing function.Chinese medicine composition preparation process is simple, can carry out large-scale industrial production, be with a wide range of applications in the health medicine or food for preparing anti-oxidant blood fat reducing function.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, and in particular to a kind of Chinese medicine group with anti-oxidant blood fat reducing function
Close object and preparation method thereof.
Background technique
Free radical refers to that reactivity is high containing atom, molecule or the ionic group of one or more unpaired electronics, is
The mesostate of many biochemical reactions, usually unstable in tissue, is easy voluntarily to be combined into stable molecule,
Or another free radical of generation is reacted with other molecules.Active oxygen refers to certain metabolites of oxygen and the oxygen-containing production of some reactions
Object, some active oxygens are also free radical, and oxygen containing free radical is known as oxygen radical, and free radical is in normal life process
It necessary to sustaining life, but needs to maintain the balance of a physiological level, otherwise living organism can also be generated a series of
Illeffects, such as: causing lipid peroxidation, lead to the change of biofilm structure and function, injury protein enzymatic activity leads to cell
Mutation etc..Therefore, the generation of biological interior free yl is highly important to being normally carried out for life process with the balance removed.
Blood lipid is primarily referred to as total cholesterol and triglycerides in serum, and hyperlipemia is primarily referred to as total cholesterol in serum
Or triglyceride levels are excessively high and serum High Density Lipoprotein Cholesterol too high levels, it is artery congee that blood lipid, which increases, in organism
The Major Risk Factors that sample hardening and cardiovascular disease generate, studies have shown that the raising of blood lipid level is internal freedom in body
The balance that base is generated and removed is destroyed, and is caused many activities of antioxidant enzymes to reduce, is generated a large amount of lipid peroxide and third
Dialdehyde, and the formation of these lipid peroxide and atherosclerosis is closely related.The cholesterol of normal human increases by 1%, suffers from
The risk of the cardiovascular diseases such as coronary heart disease increases by 3%, therefore, removes intracorporal free radical to maintenance blood lipid level and reduces the heart
The disease incidence of cranial vascular disease plays the role of positive.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine compositions with anti-oxidant blood fat reducing function, pass through Chinese medicine composition
Synergistic effect, reach anti-oxidant and reducing blood lipid double effects.
Technical solution: the invention discloses a kind of Chinese medicine composition with anti-oxidant blood fat reducing function, the Chinese traditional medicine compositions
Object is grouped as by the group of following parts by weight: 10 ~ 20 parts of Baical Skullcap root P.E, 5 ~ 10 parts of peony root extractive, ophiopogon japonicus extract 10 ~ 18
Part, 8 ~ 15 parts of Magnolia cortex P.E, 5 ~ 15 parts of loquat-leaf extract, 5 ~ 10 parts of Megranate Seed P.E, 10 ~ 20 parts of safflower extract,
12 ~ 18 parts of perilla leaf extract.
A kind of Chinese medicine composition with anti-oxidant blood fat reducing function of the present invention, the Chinese medicine composition by weighing as follows
Amount part group be grouped as: 15 parts of Baical Skullcap root P.E, 8 parts of peony root extractive, 12 parts of ophiopogon japonicus extract, 10 parts of Magnolia cortex P.E,
7 parts of loquat-leaf extract, 8 parts of Megranate Seed P.E, 13 parts of safflower extract, 14 parts of perilla leaf extract.
Radix scutellariae: cold in nature, bitter, energy heat-clearing and damp-drying drug, purging fire for removing toxin, hemostasis, miscarriage prevention and other effects.Cure mainly warm heat disease, upper breathing
The diseases such as road infection, cough with lung heat, neonatal jaundice caused by dampness-heat, pneumonia, dysentery, hemoptysis, hot eyes, threatened abortion, hypertension, carbuncle swells furuncle sore.
Tree peony root: cold in nature, bitter has clearing heat and cooling blood, analgesia dispersing blood stasis and other effects, while having anti-inflammatory, anti-aging, guarantor
Liver, cardioprotection, antineoplastic action.
Radix Ophiopogonis: sweet in flavor, slight bitter cold nature, steroid saponin, flavones, carrotene, carbohydrate effective component containing there are many, Mai Men
There is an increasing leukocyte in winter, and extending antibody, there are the effects of time, improve immune function and nucleic acid synthetic ratio, promote antibody, complement,
The immune substances such as interferon, lysozyme generate.Therefore the tuber of dwarf lilyturf has enhancing healthy tendency, reinforces anti-evil effect, to reduce disease
It generates.
Cortex Magnoliae Officinalis: it is warm-natured, it is bitter, pungent, there is CNS inhibition, of flaccid muscles, antiulcer, antibacterial, antiviral, anticancer, anti-mistake
The effects of quick, has decompression, anti-platelet aggregation, antagonism calmodulin to act on cardiovascular system.
Loguat leaf: mild-natured, bitter has the function of diuresis, heat-clearing, quenches the thirst, antibechic.
Pomegranate seed: warm-natured, sweet,sour and puckery taste cures mainly body fluid deficiency dryness of the mouth and throat, and polydipsia draws drink, chronic diarrhea, protracted dysentery, hematochezia, metrorrhagia and metrostaxis etc.
Illness.
Safflower: warm-natured, acrid flavour has and adjusts immune, reducing blood lipid, decompression, anti-inflammatory, analgesia, inhibits platelet aggregation, enhancing
Body's hypoxia tolerance and other effects.
Perilla leaf: it is acrid flavour, warm-natured, can qi-regulating, He Ying, for treating the diseases such as cold, fever with aversion to cold, cough, asthma
Disease.
In Chinese medicine composition of the present invention with anti-oxidant blood fat reducing function, the system of each component extract
Preparation Method are as follows: each component extract is prepared separately, weighs dry radix scutellariae, tree peony root, Radix Ophiopogonis, Cortex Magnoliae Officinalis, loquat respectively
Leaf, pomegranate seed, safflower, perilla leaf after being crushed, 5 ~ 10 times of ethanol solution are added thereto and extracts, mentions altogether
It taking 3 times, 1 ~ 2h, combined extract remove the dregs of a decoction, extracting solution are concentrated under reduced pressure, then is freeze-dried every time, respectively
To each component extract.
In Chinese medical extract preparation process of the present invention, the concentration of ethanol solution used in the extraction is 60 ~
95%。
In Chinese medical extract preparation process of the present invention, the method for the removal dregs of a decoction is to remove medicine by filtering
Slag, or pass through the centrifugation removal dregs of a decoction.
In Chinese medical extract preparation process of the present invention, the centrifugal rotational speed is 5000r/min, and centrifugation time is
10min。
Chinese medicine composition of the present invention with anti-oxidant blood fat reducing function is processed into oral solution, capsule, pulvis, piece
Agent or granule.
Chinese medicine composition of the present invention with anti-oxidant blood fat reducing function is preparing anti-oxidant and reducing blood lipid guarantor
Application in strong drug or food.
The utility model has the advantages that the present invention provides a kind of Chinese medicine composition with anti-oxidant blood fat reducing function and its preparation sides
Method, which includes: Baical Skullcap root P.E, peony root extractive, ophiopogon japonicus extract, Magnolia cortex P.E, loguat leaf extract
Object, Megranate Seed P.E, safflower extract, perilla leaf extract give full play to its synergistic effect by different ratio combination.Through
It crosses zoopery to obtain, Chinese medicine composition prepared by the present invention can effectively remove free radical, and have significant reducing blood lipid
Effect.Chinese medicine composition preparation process is simple, can carry out large-scale industrial production, is preparing anti-oxidant blood fat reducing function
Health medicine or food in be with a wide range of applications.
Specific embodiment
Embodiment 1
A kind of Chinese medicine composition with anti-oxidant blood fat reducing function, the Chinese medicine composition are grouped as by the group of following parts by weight:
Baical Skullcap root P.E 15g, peony root extractive 8g, ophiopogon japonicus extract 12g, Magnolia cortex P.E 10g, loquat-leaf extract 7g, pomegranate
Seed extract 8g, safflower extract 13g, perilla leaf extract 14g.
The each component extract the preparation method comprises the following steps: each component extract is prepared separately, weigh respectively dry
Dry radix scutellariae, tree peony root, Radix Ophiopogonis, Cortex Magnoliae Officinalis, loguat leaf, pomegranate seed, safflower, perilla leaf, after being crushed, are added thereto
5 times of 95% ethanol solution extracts, and extracts 3 times, each 2h altogether, combined extract, removes the dregs of a decoction by filtering, will extract
Liquid is concentrated under reduced pressure, then is freeze-dried, and each component extract is respectively obtained.
Each component is weighed according to mass parts and is mixed, 10g sodium benzoate is added thereto, and water for injection is added and is stirring
It is dissolved by heating in the state of mixing, 100 DEG C of sterilizing 30min are to get the oral solution for arriving sugar composite.
Embodiment 2
A kind of Chinese medicine composition with anti-oxidant blood fat reducing function, prepares each component extract according to the method for embodiment 1, presses
Each component extract is mixed according to following weight, Baical Skullcap root P.E 12g, peony root extractive 5g, Radix Ophiopogonis extract
Object 13g, Magnolia cortex P.E 10g, loquat-leaf extract 15g, Megranate Seed P.E 7g, safflower extract 18g, perilla leaf extract
17g。
Weigh each component according to mass parts and mix, be added thereto 95% ethanol solution solid mixture is prepared into it is soft
Material, squeezed the granulation of 20 ~ 25 meshes, and 50 DEG C of dry 4h cross 20 mesh whole grains, obtain the granule of polysaccharide composition.
Embodiment 3
A kind of Chinese medicine composition with anti-oxidant blood fat reducing function, prepares each component extract according to the method for embodiment 1, presses
Each component extract is mixed according to following weight, Baical Skullcap root P.E 18g, peony root extractive 5g, Radix Ophiopogonis extract
Object 18g, Magnolia cortex P.E 15g, loquat-leaf extract 9g, Megranate Seed P.E 10g, safflower extract 11g, perilla leaf extract
12g。
Each component is weighed according to mass parts and is mixed, and water for injection 1L is added thereto, after mixing evenly, with 0.22 μm
Filtering with microporous membrane, it is aseptic subpackaged, it is lyophilized up to pulvis.
Embodiment 4
A kind of Chinese medicine composition with anti-oxidant blood fat reducing function, prepares each component extract according to the method for embodiment 1, presses
Each component extract is mixed according to following weight, Baical Skullcap root P.E 13g, peony root extractive 6g, Radix Ophiopogonis extract
Object 15g, Magnolia cortex P.E 9g, loquat-leaf extract 14g, Megranate Seed P.E 6g, safflower extract 13g, perilla leaf extract
16g。
Each component is weighed according to mass parts and is mixed, 200 meshes are smashed it through, and is distributed into capsule up to capsule.
(2) free-radical scavenging activity
By embodiment 1 ~ 4 prepare Chinese medicine composition be each configured to 0mg/mL, 0.2mg/mL, 0.4mg/mL, 0.6mg/mL,
The concentration of 0.8mg/mL, 1.0mg/mL draw 2mL in test tube respectively, the DPPH solution of 2mL 0.2mM are added thereto,
15min is placed after mixing, is returned to zero with dehydrated alcohol, the light absorption value (A sample) of 517nm is measured, and then measures 2mL extract
With the light absorption value (A control) of the mixed liquor of 2mL dehydrated alcohol, the suction of the mixed liquor of 2mL dehydrated alcohol and 2mL DPPH solution
Light value (A blank), the calculating of clearance rate: DPPH clearance rate/%=(1-) × 100%.The results are shown in Table 1, from
It is obtained in table 1, extract of the present invention has effects that preferably to remove free radical, and with the increase of extract concentrations, clearly
Except the effect of free radical gradually increases.
Table 1
Lipid lowering properties evaluation:
50 male rats that total cholesterol level is more than 1.5mM are chosen to be tested, wherein 40 are divided into 4 groups, every 10 works
Chinese medicine composition prepared by stomach-filling embodiment 1 ~ 4 is distinguished for experimental group, in addition 10 is only used as control group and is given pure water, it is real
Testing group given low is 0.5g/kg, and daily stomach-filling is primary, altogether stomach-filling 30 days, and Rat Fast can't help water before last time stomach-filling
10h continues to be deprived of food but not water rear 2h after stomach-filling, and the total cholesterol in the hematological indices and serum of rat is measured after blood sampling
(TC), triglycerides (TG) content.The testing result of total cholesterol (TC) and triglycerides (TG) is as shown in table 2, from table
Out, after the administration of experimental group rat, TC and TG content shows significantly to decline, to show health care product pair prepared by the present invention
Blood lipid has apparent reduction effect.
Table 2
Claims (8)
1. a kind of Chinese medicine composition with anti-oxidant blood fat reducing function, which is characterized in that the Chinese medicine composition is by following weight
The group of part is grouped as: 10 ~ 20 parts of Baical Skullcap root P.E, 5 ~ 10 parts of peony root extractive, 10 ~ 18 parts of ophiopogon japonicus extract, Cortex Magnoliae Officinalis are extracted
8 ~ 15 parts of object, 5 ~ 15 parts of loquat-leaf extract, 5 ~ 10 parts of Megranate Seed P.E, 10 ~ 20 parts of safflower extract, perilla leaf extract
12 ~ 18 parts.
2. a kind of Chinese medicine composition with anti-oxidant blood fat reducing function according to claim 1, which is characterized in that in this
Drug composition is grouped as by the group of following parts by weight: 15 parts of Baical Skullcap root P.E, 8 parts of peony root extractive, 12 parts of ophiopogon japonicus extract,
10 parts of Magnolia cortex P.E, 7 parts of loquat-leaf extract, 8 parts of Megranate Seed P.E, 13 parts of safflower extract, perilla leaf extract 14
Part.
3. a kind of Chinese medicine composition with anti-oxidant blood fat reducing function according to claim 1, it is characterised in that described
Each component extract the preparation method comprises the following steps: each component extract is prepared separately, weigh dry radix scutellariae, tree peony respectively
After being crushed, 5 ~ 10 times of ethyl alcohol is added in root, Radix Ophiopogonis, Cortex Magnoliae Officinalis, loguat leaf, pomegranate seed, safflower, perilla leaf thereto
Solution extracts, and extracts altogether 3 times, and 1 ~ 2h, combined extract remove the dregs of a decoction, extracting solution are concentrated under reduced pressure every time, then into
Row freeze-drying, respectively obtains each component extract.
4. a kind of Chinese medicine composition with anti-oxidant blood fat reducing function according to claim 3, it is characterised in that described
Extraction used in ethanol solution concentration be 60 ~ 95%.
5. a kind of Chinese medicine composition with anti-oxidant blood fat reducing function according to claim 3, it is characterised in that described
Removal the dregs of a decoction method be by filter remove the dregs of a decoction, or by centrifugation removal the dregs of a decoction.
6. a kind of Chinese medicine composition with anti-oxidant blood fat reducing function according to claim 5, it is characterised in that described
Centrifugal rotational speed be 5000r/min, centrifugation time 10min.
7. the Chinese medicine composition with anti-oxidant blood fat reducing function as described in any one of claim 1 ~ 6 claim is processed into
Oral solution, capsule, pulvis, tablet or granule.
8. prepared by the Chinese medicine composition with anti-oxidant blood fat reducing function as described in any one of claim 1 ~ 6 claim
Anti-oxidant and reducing blood lipid health medicine or the application in food.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116172194A (en) * | 2021-11-28 | 2023-05-30 | 南京艾德凯腾生物医药有限责任公司 | Health food containing broad bean pod extract and application thereof |
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|---|---|---|---|---|
| CN1310019A (en) * | 2001-02-28 | 2001-08-29 | 南京中医药大学 | Maizhenhua extract as coronary heart disease treating medicine and its preparation |
| CN103828990A (en) * | 2014-03-26 | 2014-06-04 | 印江土家族苗族自治县鸿达文化旅游开发有限公司 | Radix ophiopogonis and wolfberry tea |
| CN103877152A (en) * | 2014-04-01 | 2014-06-25 | 包头市千年健医药科技有限公司 | Composition containing pomegranate seed oil and purple perilla seed oil, as well as preparation method and use thereof |
| CN108409878A (en) * | 2018-01-31 | 2018-08-17 | 湖北民族学院 | Cortex magnoliae officinalis polysaccharide and its preparation and use |
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2018
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|---|---|---|---|---|
| CN1310019A (en) * | 2001-02-28 | 2001-08-29 | 南京中医药大学 | Maizhenhua extract as coronary heart disease treating medicine and its preparation |
| CN103828990A (en) * | 2014-03-26 | 2014-06-04 | 印江土家族苗族自治县鸿达文化旅游开发有限公司 | Radix ophiopogonis and wolfberry tea |
| CN103877152A (en) * | 2014-04-01 | 2014-06-25 | 包头市千年健医药科技有限公司 | Composition containing pomegranate seed oil and purple perilla seed oil, as well as preparation method and use thereof |
| CN108409878A (en) * | 2018-01-31 | 2018-08-17 | 湖北民族学院 | Cortex magnoliae officinalis polysaccharide and its preparation and use |
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| Title |
|---|
| 元勋: "《中国分子中药学》", 31 August 2017 * |
| 易磊: "《妙用本草良方》", 31 March 2017 * |
| 陈明岭等: "《皮肤病常用中药药理及临床第2版》", 31 October 2017 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116172194A (en) * | 2021-11-28 | 2023-05-30 | 南京艾德凯腾生物医药有限责任公司 | Health food containing broad bean pod extract and application thereof |
| CN116172194B (en) * | 2021-11-28 | 2024-06-04 | 南京艾德凯腾生物医药有限责任公司 | Health food containing broad bean pod extract and application thereof |
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Application publication date: 20181228 |