CN104857154A - Traditional Chinese medicine composition for treating three-high diseases and preparation method therefor - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composition for treating three-high diseases and a preparation method therefor. The traditional Chinese medicine composition comprises the following raw materials: red sage root, pseudo-ginseng, radix polygoni multiflori, haws, wolfberries and cassia seeds. The traditional Chinese medicine composition can be prepared into any common oral administration dosage form or health product, has functions of promoting blood circulation to remove blood stasis, benefiting liver and kidney, raising internal organ functions and promoting metabolism, and can lower blood glucose and blood fat and inhibit blood medicine rise. The traditional Chinese medicine composition has substantial curative effects of treating hypertension, hyperlipidemia and diabetes, the total effective rate for three-high diseases can reach more than 90% and no rebound is generated after the medicine is stopped. The Traditional Chinese medicine composition has minimal side effects and can be taken for a long time.

Description

Chinese medicine composition of a kind for the treatment of " three-hypers " disease and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine composition and preparation method thereof, particularly a kind of Chinese medicine composition and preparation method thereof being used for the treatment of hypertension, hyperlipidemia, hyperglycaemic conditions.

Background technology

Three-hypers disease refers to hypertension, hyperglycemia, hyperlipidemia, they be modern society derive from " affluenza ", possible individualism, also may be interrelated.Three-hypers disease is the arch-criminal causing the cardiovascular and cerebrovascular disease such as apoplexy, heart disease, and along with the raising of people's living standard, the ratio that hyperlipidemia, hypertension and hyperglycemia are suffered from simultaneously is more and more higher, and the abnormal trouble for the treatment of.

Suffer from that to send out hypertension, hyperlipidemia, hypercholesterolemia and a cerebral thrombosis, cardiopathic crowd increasing in recent years, and also more and more rejuvenation, according to medical survey statistics, on average had more than 6% age to suffer from hypertension, hypercholesterolemia the people of 25 years old-35 years old.Fat has ambiguity male in the majority, accounts for 3.8% of number, and crowd's hypertension, hyperlipidemia, hypercholesterolemia, the fatty liver of 35 years old-45 years old.The diseases such as heart disease account for crowd's more than 15%, wherein, hold concurrently and suffer from hypertension, cardiopathicly account for more than 4.5%, and middle-aged and elderly people suffers from hypertension, cardiac cerebral arteriosclerosis, hyperlipidemia, cerebral thrombosis, cardiopathic number accounts for crowd's 18.7%, wherein, more than 55 years old account for 14.5% of sum, and to increase year by year with the rate of climb of 1.2% every year, had a strong impact on the life and health of people.

Hypertension a kind ofly continues to raise as the chronic disease of main manifestations with arteriotony, often causes the pathological changes of the vitals such as the heart, brain, kidney and occur corresponding consequence.Many by emotional maladjustment, excessive rising of liver-YANG, liver-wind stirring up internally, flaming up of liver-fire, depression of liver-QI, ponders over transition; The hepatic and renal YIN deficiency, deficiency of kidney-essence, kidney yang deficiency, deficiency of marrow-reservoir or addicted to food delicious food, stagnation of phlegm-damp in middle-JIAO, dysfunction of the spleen in transportation, essence of water and grain can not change angry blood, causes the formation of hypertension; Can show as headache, dizziness, tinnitus, cardiopalmus, dim eyesight, the symptom such as absent minded in early days, later stage blood pressure often continues in higher level, and with impaired organ such as brain, the heart, kidneys.

Hyperglycemia is because insulin is relatively or definitely not enough, makes that the one of the nutrient metabolic exceptions such as carbohydrate in body, fat, protein is chronic, lifelong disease.This disease can cause multiple complications, can cause systemic disease time serious, people is disabled, blinding, even lethal.The diabetes of diabetes traditional Chinese medical science meaning, contain in phlegm-damp, dysfunction of the spleen in transportation and transformation, eating and drinking without temperance, greasy and surfeit flavour, stasis heat-dissipating, injuring YIN due to production of dryness, rapid digestion of food and polyorexia, disturbance in functioning of QI, causes drinking water copiously frequent micturition, the disease of quenching one's thirst gradually life.

Hyperlipemia is due to eating and drinking without temperance, and addicted to food greasy and surfeit flavour, transporting and transforming function of the spleen and stomach is not normal, and phlegm-damp hinders and forms heart arteries and veins stasis blocking in venation, and mind is failed to understand; Or aged debility, natural endowment is not enough, kidney Qi deficiency, and kidney yang is agitated unfavorable, the hepatic and renal YIN deficiency, and liquid is hindered in bright Tianjin, old temper transporting mistake department, forms hyperlipemia.Hyperlipidemia can give rise to diseases, and comprises coronary atherosclerosis, heart infarction, hypertensive cardiopathy, cardiomyopathy, cerebrovascular, cerebral arteriosclerosis, cerebral thrombosis, liver cirrhosis, renal arteriosclerosis, diabetes etc., serious harm people life and health.

That supplies in the market is most just for the medicine of single disease a certain in three-hypers disease, and the needs of patients for the various disease conditions suffered from hypertension, hyperlipidemia, hyperglycemia simultaneously takes multi-medicament simultaneously, brings great inconvenience to patient.These medicines are generally in the majority with Western medicine, such as, prevent and treat the Western medicine of cardiovascular and cerebrovascular disease, and mainly with Diastolic arterial blood vessel and anticoagulant, it is main for reducing blood viscosity, as nitroglycerin, and aspirin etc.Chinese patent medicine is mainly with blood circulation promoting and blood stasis dispelling, and thrombolytic is promoted blood circulation, as Radix Salviae Miltiorrhizae drop pill, and FUFANG DANSHEN PIAN etc.The weak point of Western medicine is: although Western medicine energy quick symptom relief, relapse rate is high, and will rebound after drug withdrawal, can not play radical cure effect, must uninterruptedly take medicine for a long time, to patient with larger financial burden.Meanwhile, Western medicine toxic and side effects is comparatively large, and long-term prescription also can cause certain infringement to patient body; Though and Chinese patent medicine can blood circulation promoting and blood stasis dispelling, thrombolytic is promoted blood circulation, blood fat reducing, blood pressure lowering, medicine a multitude of names that market is sold, and mostly compares specificity, and in blood fat reducing, blood pressure lowering, softening tremulous pulse and the most effect of thrombolytic and elimination blood molten rubbish aspect not ideal enough.

Prove according to medical research, hyperlipidemia, hypercholesterolemia, the formation of fatty liver is mainly because of a large amount of high fat of surfeit in daily life, high heat food, and lack certain sports, significant quantities of fat in body is made to can not get active combustion metabolism, cause piling up precipitation in internal organs and blood, and accumulate increase gradually, form internal organs and blood rubbish, As time goes on, these blood rubbish can slowly along with blood vessel and blocking human circulation, especially microcirculation, as cerebral thrombosis, artery plaque etc., because blood fat and blood viscosity raise, blood circulation resistance strengthens, heart will inevitably strengthen contraction dynamics, to such an extent as to blood pressure raises, in high strength, under prolonged exercise, namely heart arter is subject to grievous injury.Especially person in middle and old age and the excessive crowd of tobacco and wine, due to organ senescence or in advance so that heart infarction, cerebral infarction aging, M & M account for this and first of.Therefore develop a kind of efficient and treating both the principal and secondary aspects of a disease safely and fast and there is the Chinese patent medicine of prevention and health care performance, being of great immediate significance.

Summary of the invention

Primary and foremost purpose of the present invention is Chinese medicine composition providing a kind for the treatment of " three-hypers " disease and preparation method thereof for the problems referred to above, compositions of the present invention is for the pathogenesis etiology of hypertension, hyperglycemia, hyperlipidemia, employing plurality of Chinese cooperatively interacts, the mutual Synergistic of its active component, effectively reduce blood pressure, blood glucose and blood fat, the curative effect of the present composition to prevention and therapy " three-hypers " disease is high, without any side effects, and after drug withdrawal, blood pressure, blood glucose and blood fat do not rebound.

For realizing object of the present invention, one aspect of the present invention provides a kind of Chinese medicine composition for the treatment of " three-hypers " disease, comprises following raw material: Radix Salviae Miltiorrhizae, Radix Notoginseng, the Radix Polygoni Multiflori, Fructus Crataegi, Fructus Lycii, Semen Cassiae.

Wherein, the weight of the crude drug of the Chinese medicine composition of described treatment " three-hypers " disease is: Radix Salviae Miltiorrhizae 5-35, Radix Notoginseng 7-20, Radix Polygoni Multiflori 5-30, Fructus Crataegi 10-30, Fructus Lycii 10-25, Semen Cassiae 7-30.

Particularly, the weight of described crude drug is preferably: Radix Salviae Miltiorrhizae 10-20, Radix Notoginseng 10-15, Radix Polygoni Multiflori 10-20, Fructus Crataegi 20-30, Fructus Lycii 10-15, Semen Cassiae 10-25.

Especially, the weight of described crude drug is: Radix Salviae Miltiorrhizae 15, Radix Notoginseng 10, the Radix Polygoni Multiflori 15, Fructus Crataegi 20, Fructus Lycii 15, Semen Cassiae 15.

The Chinese medicine composition for the treatment of of the present invention " three-hypers " disease is to hypertension based on the traditional Chinese medical science, diabetes and diabetes and the pathogenetic of hyperlipidemia fully realize and study, in conjunction with the achievement of modern pharmacy and pharmaceutical research, selectively Radix Salviae Miltiorrhizae, Radix Notoginseng, the Radix Polygoni Multiflori, Fructus Crataegi, Fructus Lycii, Semen Cassiae carries out scientific composition and is prepared from, with the Chinese crude drug of pure natural for raw material, have no side effect, it passes through blood circulation promoting and blood stasis dispelling, the liver and the kidney tonifying, improve organ function, enhance metabolism, reach treatment hypertension, hypercholesterolemia, arteriosclerosis and cerebral thrombosis, the object of hyperlipidemia and complication.

Wherein, Radix Salviae Miltiorrhizae is the dry root and rhizome of labiate Radix Salviae Miltiorrhizae, cold nature, bitter in the mouth, and GUIXIN, Liver Channel, have stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, the effect of the relieving restlessness that clears away heart-fire, is mainly used in menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris etc.

Containing liposoluble constituent in Radix Salviae Miltiorrhizae: tanshinone Ⅰ, II A, II B, Isotanshinone I., II A, cryptotanshinone, different cryptotanshinone, methyltanshinone, hydroxytanshinone ⅡA Hydroxytanshinone IIA., danshenxinkun A, B, C, Dihydroisotanshinone Ⅰ, new cryptotanshinone, remove the new cryptotanshinone of hydroxyl etc.; Water miscible phenol acid compound: Salvianic acidA, B, C, salviol acid A, B, C, D, E, G, rosmarinic acid, methyl rosmarinate, alkannic acid mono methyl ester, alkannic acid dimethyl ester, alkannic acid ethyl ester, alkannic acid, protocatechualdehyde, caffeic acid, Hesperetic acid etc.

Radix Salviae Miltiorrhizae has antitumor, resists myocardial ischemia, anti-heart infarction, anticoagulation, activation fibrinolytic, stablize erythrocyte membrane, anti-liver pulmonary fibrosis, antiinflammatory, antibacterial, antiulcer and resisting oxygen lack.Experimentally study proof, Radix Salviae Miltiorrhizae obviously can reduce the serum-concentration of blood urea nitrogen, creatinine methylguanidine, guanidine radicals succinic acid, both improves hyperphosphatemia, which in turn improves the crystal formation of blood Free Amino Acids, effectively promotes graft function.There is adjustment Coagulation Fibrinolysis; the state of platelet system; there are increase flow and dilate coronary effect also can reduce coronary resistance to coronary artery circulation; stronger protective effect is had to heart infarction and myocardial ischemia; Radix Salviae Miltiorrhizae has anticoagulant, activates fibrinolytic, stablizes the effect of erythrocyte membrane; and have antibacterial, antiinflammatory and the effect to organs and tissues fibrosis.

Radix Notoginseng, also known as Radix Notoginseng, Yunnan seven, Radix Notoginseng, Radix Notoginseng, is the dry root of panax araliaceae plant.Warm in nature, sweet in the mouth, micro-hardship, returns liver, stomach warp.There is dissipating blood stasis hemostasis, subduing swelling and relieving pain.For spitting of blood, spit blood, epistaxis, has blood in stool, metrorrhagia, traumatic hemorrhage, and breast abdomen twinges, tumbling and swelling.The main active component containing multiple dammarane type four-ring triterpenoid Saponin in Radix Notoginseng.As arasaponin A, arasaponin B, after the two hydrolysis, generate ruscogenin A respectively, ruscogenin B and a part glucose; Also containing ginsenoside-Rb1 ,-Rb2 ,-Rd ,-Re ,-Rg1, Herb Gynostemmae Pentaphylli glycoside, there is the necessary aminoacid (as glutamic acid, arginine, lysine, leucine etc.) of the dencichine (i.e. dencichine) of anastalsis, sanchinan-A, B and multiple human body, also contain.

Modern pharmacological research shows that Radix Notoginseng can improve the immunocompetence of body, can significantly improve phagocytic rate and the phagocytic index of Turnover of Mouse Peritoneal Macrophages.Wherein, it is active that sanchinan-A obviously can reduce natural killer cell (NKC), and when drug dose strengthens, inhibitory action is strengthened.Obviously can promote during Polysaccharide B low concentration that natural killer cell (NKC) is active, increase facilitation with concentration and weaken.Polysaccharide A makes serum lysozyme content increase when 25mg/kg, other dosage is without impact; Polysaccharide B also has facilitation to lysozyme.Polysaccharide A can make peritoneal exudate cells lysozyme content increase when 5mg/kg, and endocellular enzyme content can be made significantly to increase when more than 25mg/kg, and enzyme content can be made during Polysaccharide B low dosage to increase, and high dose is then without impact.Two kinds of Polysaccharides on Mice antigen binding cell all have inhibitory action, and the inhibitory action of Polysaccharide A is strengthened with the increase of dosage, and Polysaccharide B inhibitory action when more than 25mg/kg dosage is plateau phenomenon.Radix Notoginseng two kinds of polysaccharide antagonist secretory cells all have obvious inhibitory action.Two kinds of polysaccharide also all have obvious inhibitory action to Plaque forming cell (PFC).Radix Notoginseng total arasaponins (PNS) can also significantly improve the effect of pulmonary alveolar macrophage phagocytic rate, to Wistar rats by intraperitoneal injection Radix Notoginseng total arasaponins, result shows, administration group pulmonary alveolar macrophage phagocytic rate significantly improves, and after administration, blood leucocyte sum improves obviously.To the rat oral gavage Radix Notoginseng total arasaponins of Ovum Gallus domesticus album pedal swelling, result illustrates that Radix Notoginseng fibrous root Total saponin has obvious antiinflammatory inhibitory action to rat paw swelling induced by egg.Radix Notoginseng extract can improve body hepatic glycogen, and normal mouse gavage Radix Notoginseng extract 15 days and 25 days, hepatic glycogen improves 80.8% and 71% respectively.Result illustrates that Radix Notoginseng extract can promote that mice utilizes exogenous glucose to synthesize hepatic glycogen, and in the hepatocyte of the mice of administration Radix Notoginseng extract, most glycogen granule is thick full.Radix Notoginseng has arrhythmia, coronary artery dilating and increase coronary flow, anti-impatient ischemia and increasing myocardial contraction, improve the effect of myocardial hypoxia tolerance, especially animal content of triglyceride and atherosclerosis can significantly be reduced, the formation of endarterium speckle also reduces platelet, thromboxane A2 (TXA2) content.Radix Notoginseng has antithrombotic, atherosclerosis and effect for reducing blood fat and antibacterial, antiinflammatory, improves immunity and antioxidation and antidotal effect.

Radix Polygoni Multiflori is the dried root of polygonum multiflorum thunb Polygonum multiflorum Thunb., warm in nature, bitter in the mouth, sweet, puckery; Return liver, the heart, kidney channel.Have removing toxic substances, eliminating carbuncle, loosening bowel to relieve constipation, tonifying liver, kidney tonifying, nourishes blood, the effect of dispeling the wind, and is mainly used in treating hepatic and renal YIN deficiency, and sending out must be early white, and blood deficiency is dizzy, and waist knee joint is weak, and muscles and bones is ached, seminal emission, metrorrhagia and leukorrhagia, chronic malaria, chronic dysentery, chronic hepatitis, carbuncle, scrofula, hemorrhoidal hamorrhage, haemorrhoids.Radix Polygoni Multiflori Preparata invigorating the liver and kidney, benefiting essence-blood, black beard and hair, strengthening bone and muscle; For vertigo and tinnitus, early whitening of beard and hair, soreness of the waist and knees, numb limbs and tense tendons, neurasthenia, scrofula carbuncle sore, rubella pruritus, dryness of the intestine constipation; Hyperlipidemia.

The root welding technology of Radix Polygoni Multiflori, containing Anthraquinones, is mainly chrysophanol and emodin, is secondly (without chrysophanic acid after processing) such as the physcione of chrysophanic acid, trace and chrysophanic acid anthrones.In addition, starch-containing 45.2%, crude fat 3.1%, lecithin 3.7% etc.

Modern pharmacological research shows: Radix Polygoni Multiflori has the effect of blood fat reducing, to rabbit feed Radix Polygoni Multiflori and cholesterol simultaneously, the matched group that the tremulous pulse medicated porridge sample pathological changes that it is formed more singly feeds cholesterol is light, serum cholesterol levels is also lower, in vitro tests Radix Polygoni Multiflori can be combined with cholesterol, can reduce cholesteric absorption at rabbit intestinal; No matter Shouwuyishoudan, to the Columba livia of experimental atherosclerosis, is that medicine and cholesterol are applied simultaneously, or with administration after cholesterol formation hypercholesterolemia, all can show reduction serum ornitrol; Shouwuyishoudan has the formation of the aortic tunica intima speckle of Experimental Atherosclerotic Rabbits and lipidosis and alleviates effect; Have hypoglycemic effect, rising to blood glucose amount in after the oral Radix Polygoni Multiflori decoct of rabbit 30 ~ 60 minutes reaches topnotch, and then reduce gradually, after 6 hours, blood glucose amount is lower by 0.03% than normally; Antibacterial action, Radix Polygoni Multiflori has inhibitory action to mycobacterium hominis, bacterium flexneri tube assay; And the chrysophanol proposed in Radix Polygoni Multiflori, the motion of intestinal tube can be promoted, and neural duration of die-offing, impel neural excitation, increase muscle duration, make muscular paralysis.Radix Polygoni Multiflori has excitation to isolated frog heart, and especially to the heart of fatigue, cardiotonic is more remarkable.Radix Polygoni Multiflori stem fresh milk is applied in the outside of belly of mouse ear, after smearing medicine, the outside of belly of ear and the back side are all seen and are thickened, and its change is histologically similar to by the result of phospholipid gained; Can be used to treat scrofula.。

Fructus Crataegi another name red fruit, Fructus Crataegi are the dry mature fruit of rosaceous plant Fructus Pyri Pashiae or Fructus Crataegi, slightly warm in nature; Sour in the mouth, sweet; Return spleen, stomach, Liver Channel.Fructus Crataegi has promoting digestion and invigorating the stomach, effect of circulation of qi promoting dissipating blood stasis, for meat stagnation, and gastral cavilty distension, dysentery is suffered from abdominal pain, gastric acid, dysentery, hemorrhoidal hamorrhage, hernia, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, hernia pain; Hyperlipemia.

Fructus Crataegi mainly contains epicatechin, Quercetin, hyperin, chlorogenic acid, Crataegolic acid, citric acid, citric acid mono-methyl, citric acid dimethyl ester, trimethyl citrate, ursolic acid, amygdalin, flavan polymers, digestive enzyme and trace element, copper, zinc, ferrum etc.According to pharmacological research, Fructus Crataegi have anticancer, antibacterial, strengthen myocardial contraction, blood pressure lowering, blood fat reducing, cholesterol reducing, diuresis, arteriosclerosis, contained lipase can promote steatolysis and strengthen digestion and metabolism function.The lipase that Fructus Crataegi contains can promote lipid metabolism, and can increase the secretion of peptic digestion enzyme, facilitating digestion, has certain regulating action to gastrointestinal function; Crataegus pin natifida var. Major extract and the oral lecithin that to make in atherosclerosis rabbits blood of alcohol extractum improve, and cholesterol and the lipid deposition on organ reduces.Fructus Crataegi water decoction has inhibitory action to cholesterol biosynthesis enzyme activity, and the 3-hydroxy-3-methylglutaryl coenzyme A reductase vigor of its hepatocyte microsome and mucous membrane of small intestine can be made to decline.Fructus Crataegi aqueous extract can show reduction serum total cholesterol content, and its effect is significantly higher than pantethine, and obviously can increase HDL-C, HDL2-C, HDL3-C concentration in serum; Fructus Crataegi aqueous extract has scavenging activated oxygen, suppresses mouse liver lipid peroxidation, lowers the hyaluronic acid depolymerisation through oxygen-derived free radicals induction.Fructus Crataegi has anticancer antibiotic, blood fat reducing, blood pressure lowering, strengthens myocardial contraction and cholesterol reducing, arteriosclerosis, and contained lipase can promote steatolysis and strengthen digestion and metabolism function;

Fructus Lycii is the dry mature fruit of plant of Solanaceae lycium barbarum, and property is put down, and sweet in the mouth, returns liver, kidney channel.There is nourishing the liver and kidney, the function of replenishing vital essence to improve eyesight, be mainly used in asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand, seminal emission, night sweat, blood deficiency yellowish complexion, neurasthenia, hepatitis, carbuncle, chilblain, scald, decubital ulcer, chronic atrophic gastritis, stomach and duodenal bulbar ulcer, be used for the treatment of hepatic and renal YIN deficiency, soreness of the waist and knees, have a dizzy spell, cough due to consumptive disease, quench one's thirst seminal emission, blood deficiency and yellow complexion, neurasthenia etc.Be usually used in the hepatic and renal YIN deficiency, soreness of the waist and knees, have a dizzy spell.

Containing containing carotene, thiamine, riboflavin, nicotinic acid, ascorbic acid, betanin, atropine, hyoscyamine, physalin etc. in the fruit of Fructus Lycii; Containing aminoacid in the seed of Fructus Lycii: aspartic acid, proline, alanine, leucine, phenylalanine, serine, glycine, glutamic acid, cysteine, lysine, arginine, isoleucine, threonine, histidine, tyrosine, tryptophan, methionine etc.

Modern pharmacological research shows that Fructus Lycii has lipotropic effect, the infusion (20%, 8 milliliters of/day gavages) of Fructus Lycii, to the mice poisoned by carbon tetrachloride, has the effect suppressing fat deposition, promotion hepatocyte new life in hepatocyte.The lipotropic effect of water extract also shows, prevents the liver dysfunction that carbon tetrachloride causes.Fructus Lycii is to lipid metabolism or lipotropic effect, and mainly caused by wherein contained betanin, betanin plays methyl supplying in vivo.Lycium barbarum polysaccharide has the effect of significant immunostimulant and regulating action, reduction blood glucose, blood fat to mice nonspecific immunity and specific immunity, can the effect of slow down aging and resisting fatigue.Experimental study proves: Fructus Lycii effectively can improve hepatic and renal function and there is immunoloregulation function and defying age, short hemopoietic, blood fat reducing and protect the liver, lipotropic effect, and there is significant blood sugar decreasing effect, its mechanism of action is, contained guanidine derivatives can effectively suppress animal blood glucose to raise, and animal is improved the tolerance of carbohydrate.Fructus Lycii also has anticancer, promotes immunity moderation function and defying age, blood fat reducing, the effect of anti-fatty liver and promotion hemopoietic;

Semen Cassiae, also known as Horse hoof Semen Cassiae, blunt leaf Semen Cassiae, false Semen phaseoli radiati, Semen Cassiae, is the dry mature seed of pulse family annual herb plant Semen Cassiae or little Semen Cassiae, cold nature, sweet in the mouth, hardship, salty; Return liver, kidney, large intestine channel.Have clearing away heat to improve acuity of vision, effect of loosening bowel to relieve constipation, be mainly used in the puckery pain of conjunctival congestion, the many tear of photophobia, has a headache dizzy, poor vision, constipation.There is effect of fat-reducing.Control wind heat acute conjunctivitis, optic atrohic blindness, nyctalopia, hypertension, hepatitis, cirrhotic ascites, habitual constipation etc.The chemical composition of Semen Cassiae is mainly containing emodin, chrysophanol, physcione, obtusin, obtusin and glycoside thereof; Also containing multivitamin and abundant aminoacid, fat, carbohydrate etc., its health care is subject to people's attention day by day.

Pharmacological research shows that Semen Cassiae has blood pressure lowering, blood fat reducing, cholesterol reducing, protects the liver, the effect of loosening bowel to relieve constipation and promotion gastric secretion: infusion, the alcohol immersion of Semen Cassiae all have hypotensive effect to anesthetized dog, cat, rabbit etc., and hypotensive effect is obvious, and the persistent period is longer; Mice fed by high fat beverage containing Semen Cassiae, and energy is increasing serum highdensity lipoprotein-cholesterol (HDL-C) content and raising HDL-C/TC ratio obviously, namely obviously improves the distribution situation of body inner cholesterol, be conducive to prevention of arterial atherosis; Semen Cassiae is loose the effect reducing experimental atherosclerosis rats total plasma cholesterol and triacylglycerol (triglyceride), can also reduce the effect of triacylglycerol and anticoagulant in liver.In Semen Cassiae, anthraquinone analog compound has effect for reducing blood fat to have data to prove.Under the rushing down of Semen Cassiae, composition and the Sennoside A model of action in mice is identical, namely under intestinal bacterium effect, generates and plays a role to the material of intestinal tube effect.One of material under the rushing down that Semen Cassiae contains is the chrysophanol dianthrone glycoside being equivalent to Sennoside A.The fluid extract of Semen Cassiae also can promote the secretion of gastric juice.Semen Cassiae alcohol extract all has inhibitory action to staphylococcus, diphtheria corynebacterium, Bacillus typhi, Salmonella paratyphi, escherichia coli; Semen Cassiae water logging agent and ethanol immersion all have hypotensive effect to anesthesia Canis familiaris L., cat, rabbit.Semen Cassiae decoct or Trial On The Action of Semen Cassiae Powder 6g/ feed rat 8 weeks, can reduce blood plasma ornitrol, triglyceride to Experimental Hyperlipemia disease rat, and reduce the content of triglyceride in liver.Semen Cassiae decoct or powder 6g/kg feed rat 8 weeks, have inhibitory action to the rat platelet aggregation of ADP induction.

The present invention's treatment " three-hypers " disease Chinese medicine composition (i.e. herbal three-hypers Yikang ball) forms according to the function of above medicine and the special role compatibility of chemical composition, is with Radix Salviae Miltiorrhizae, Radix Notoginseng, blood circulation promoting and blood stasis dispelling, unimpeded passages through which vital energy circulates, falls clearly blood rubbish silt resistance; The Radix Polygoni Multiflori, Fructus Lycii the liver and the kidney tonifying, blood-supplementing blood-nourishing, blood fat reducing, cholesterol reducing, collaborative Fructus Crataegi, Semen Cassiae blood fat reducing, blood pressure lowering, softening tremulous pulse, full side's compatibility is by the synergism of medicine, and to human body heart and brain tremulous pulse, blood circulation has attacked benefit, effectively purify, cleaning and reparation, make the blood clean of people, trickle smooth and easy, without hindrance, the heart can not obstruct, brain can not be filled in, and pressure can not be high, effectively reaches the object for the treatment of both the principal and secondary aspects of a disease.Crowd's experimentation according to herbal three-hypers Yikang ball proves, not only drug treatment is short for this Yikang ball, instant effect, and safe without toxic side effect.

The present invention provides a kind of preparation method of Chinese medicine composition for the treatment of " three-hypers " disease on the other hand, comprises the steps:

1) raw material: 105-25, Semen Cassiae 7-30 is prepared according to following weight

2) by after Radix Salviae Miltiorrhizae, Radix Polygoni Multiflori, Fructus Lycii and Semen Cassiae mix homogeneously, heating extraction is carried out to mixed material medicine, collect extracting solution;

3) concentration is carried out to the extracting solution collected, obtained Radix Salviae Miltiorrhizae-Radix Polygoni Multiflori-Fructus Lycii-Semen Cassiae concentrated solution;

4) crude drug Fructus Crataegi, Radix Notoginseng are carried out pulverization process, obtained Fructus Crataegi fine powder, Radix Notoginseng fine powder;

5) Fructus Crataegi fine powder, Radix Notoginseng fine powder and Radix Salviae Miltiorrhizae-Radix Polygoni Multiflori-Fructus Lycii-Semen Cassiae concentrated solution are mixed, to obtain final product.

Wherein, step 1) described in crude drug weight be preferably: Radix Salviae Miltiorrhizae 10-20, Radix Notoginseng 10-15, Radix Polygoni Multiflori 10-20, Fructus Crataegi 20-30, Fructus Lycii 10-15, Semen Cassiae 10-25.

Particularly, the weight of described crude drug is: Radix Salviae Miltiorrhizae 15, Radix Notoginseng 10, the Radix Polygoni Multiflori 15, Fructus Crataegi 20, Fructus Lycii 15, Semen Cassiae 15.

Wherein, step 2) described in heating extraction comprise the step that following order carries out:

A) mixture of Radix Salviae Miltiorrhizae, Radix Polygoni Multiflori, Fructus Lycii and Semen Cassiae is added water soaking, the weight of the water added is 6-8:1 with the ratio of the weight of mixture, soak and carry out first time heating extraction after 1-3 hour, heating-up temperature is 100 DEG C, under maintenance temperature is the condition of 100 DEG C, extract 1-3 hour;

B) first time extracting solution is filtered, collect filtrate;

C) in filtering residue, add water, carry out second time heating extraction, wherein, the weight of the water added is 5-7:1 with the ratio of the weight of mixture, and heating-up temperature is 100 DEG C, under maintenance temperature is the condition of 100 DEG C, extract 1-3 hour;

D) filter, the filtrate of twice filtration is merged.

Particularly, steps A) described in soak time be preferably 2 hours; Described first time heating extraction time 2 h; The weight of the water added is preferably 8:1 with the ratio of the weight of mixture; Step C) in the weight of water that adds be 6:1 with the ratio of the weight of mixture; The time of second time heating extraction is 2 hours.

Wherein, step 3) described in filtrate concentration process in control temperature be 80-100 DEG C, relative pressure is lower than-0.05MPa.

Particularly, described relative pressure is preferably-0.05 ~-0.1MPa, more preferably-0.05 ~-0.095MPa.

Described relative pressure is a kind of using atmospheric pressure as the pressure represented by benchmark, is the one of the method for expressing of pressure.Relative pressure=absolute pressure-atmospheric pressure.

Particularly, step 3) described in the weight of concentrated solution be 0.4-0.7:1 with the ratio of the gross weight of crude drug Radix Salviae Miltiorrhizae, Radix Polygoni Multiflori, Fructus Lycii and Semen Cassiae, be preferably 0.5-0.6:1, more preferably 0.6:1.

Wherein, the granularity of Fructus Crataegi described in step 4, Radix Notoginseng fine powder is less than 100 orders, is preferably less than 200 orders, more preferably 200-300 order.

Particularly, also comprise step 6) in Radix Salviae Miltiorrhizae-Radix Polygoni Multiflori-Fructus Lycii-Semen Cassiae concentrated solution and Fructus Crataegi, Radix Notoginseng fine powder mixture, add pharmaceutically acceptable adjuvant, mix.

Particularly, after adding food preservative mix homogeneously, in pellet processing machine, pill is made.

Particularly, after adding adjuvant dextrin and food preservative mix homogeneously, in pellet processing machine, pill is made.

Especially, the weight proportion of described crude drug gross weight and dextrin is 10:100; Described crude drug gross weight is 100:0.05-0.5 with the ratio of the weight of food preservative.

Particularly, described food preservative selects potassium sorbate, sodium diacetate, benzoic acid and salt thereof, calcium propionate, sodium lactate or dehydro sodium acetate.

Another aspect of the invention provide a kind for the treatment of " three-hypers " disease of being made up of acceptable auxiliary material combination on above-mentioned arbitrary described Chinese medicine composition and pharmaceutics pharmaceutical preparation.

Wherein, pharmaceutical composition of the present invention can with acceptable adjuvant on pharmaceutics by tradition or the oral type of the clinical acceptable of modern production process processing procedure.As capsule, tablet, granule, pill, oral liquid etc.Excipient substance used can be starch, dextrin, lactose, microcrystalline cellulose, gelatin, sucrose, magnesium stearate etc.Need long-term prescription clinically, it is convenient to make solid preparation storage, and patient takes facility, also more meeting the market requirement.Preferred dosage form is capsule, granule, tablet.

Further aspect of the present invention provides a kind of above-mentioned arbitrary described Chinese medicine compositions in the application of the medicine of preparation treatment " three-hypers " disease.

Drug regimen of the present invention is that tool has the following advantages:

1, medicament composing prescription compatibility science of the present invention, determined curative effect, safety is high, quality controllable;

2, pharmaceutical composition of the present invention has blood circulation promoting and blood stasis dispelling, the liver and the kidney tonifying, raising organ function, effect of enhancing metabolism, there is the effect of excellent anti-" three-hypers (i.e. resisting hypertension, lipidemia, hypercholesterolemia, arteriosclerosis and thrombosis) ", the Be very effective for the treatment of " three-hypers " disease;

3, pharmaceutical composition action pathway of the present invention is many, drug target is many, mechanism of action is unique, medicine is for key pathological link, medicine resists the evident in efficacy of " three-hypers ", and the clinical symptoms of hypertension, hyperlipidemia, hyperglycemia obviously reduces, and effective percentage reaches more than 90%, and without repeatedly after treatment, without any side effects.

4, drug medication amount of the present invention is low, with low cost.

5, the process of preparing of the Chinese medicine composition of the present invention's treatment " three-hypers " disease is simple, constant product quality successful, and easy to use.

Detailed description of the invention

Set forth the beneficial effect of medicine of the present invention further below by way of test example, these test examples include the pharmacodynamics test of medicine of the present invention.

Test example 1 treats the clinical observation on the therapeutic effect of " three-hypers " disease

1, object of study

Choose tested case 410 example of year July in April, 2010 to 2013 in Gate of Pervasive Peace Affiliated Hospital of Beijing University of Chinese Medicine, patient age 35-70 year, accept voluntarily to observe treatment.

Tested patients 210 example, wherein male patient 122 example; Female patient 88 example.Patient age 35-70 year, average 49.5 years old, course of disease 1-23.Wherein, type Ⅱdiabetes mellitus complicated hypertension 43 example; Diabetes with Hypertension, hyperlipidemia 67 example; Essential hypertension complication with diabetes, hyperlipidemia 55 example; Diabetes and hyperlipidemia complications disease 45 example.

Matched group patient 200 example, wherein male patient 128 example; Female patient 72 example.Patient age 35-70 year, average 47.2 years old, course of disease 1-20.Wherein, type Ⅱdiabetes mellitus complicated hypertension 41 example; Diabetes with Hypertension, hyperlipidemia 70 example; Essential hypertension complication with diabetes, hyperlipidemia 48 example; Diabetes and hyperlipidemia complications disease 41 example.

2 groups of cases there are no significant in sex, the course of disease, age distribution etc. difference, has comparability.

Wherein patient age is less than 35 years old, is greater than 70 years old; Be in gestation or women breast-feeding their children; Merge the serious diseases such as the heart, liver, kidney, brain; Other goods fat-reducing medicament of stopping using is being used to be discontented with the patient of 1 month not in this trial stretch.

2, case selection

The diagnosis of type Ⅱdiabetes mellitus meet 1997 ADA (ADA) standard (money is honourably obtained, diabetes clinical guidelines [M]. Beijing: publishing house of Beijing Medical University.2000.214-218)。Hyperlipidemia diagnosis reference " traditional Chinese medical science Clinical Researches of New Drugs guideline " (Ministry of Health of the People's Republic of China. traditional Chinese medical science Clinical Researches of New Drugs guideline. second volume of [S] .1995.171-174.) middle related standards: in normal diet situation, as 2 times are surveyed serum total cholesterol (TC) >=6.0mmol/L in 2 weeks, or serum levels of triglyceride (TG) >=1.54mmol/L or highdensity lipoprotein-cholesterol (HDL-C): male≤1.04mmol/L, women≤1.77mmol/L person.Hypertensive diagnosis meet WHO1999 announce " Hypertension Guideline " (WHO.1999 World Health Organization (WHO)/international hypertension alliance is about Treatment Guidelines for Hypertension [J]. hypertension magazine .1999. (7): 97-100) in hypertension definition and classification, criteria for classification.

The Syndrome Differentiation of Traditional Chinese Medicine of " three-hypers " disease is with hyperactivity of YANG due to deficiency of YIN, and syndrome of liver-stomach heat, the types such as the qi-asthenia phlegm stasis of blood are main, and the state of an illness belongs to deficiency in origin and excess in superficiality, and disease is positioned at liver,kidney,spleen.Therapeutic Principle is Replenishing QI and nourishing YIN, suppressing the hyperactive liver to relieve the wind syndrome, dissipating phlegm and removing blood stasis, clearing away heat-damp and promoting diuresis.

3, Therapeutic Method

3.1 trial drugs and usage:

Tested group of other herbal three-hypers Yikang ball adopting the embodiment of the present invention 1 to prepare, every day 3 times, each 6 grams, equal half an hour ante cibum takes after mixing it with water, and other medicines of stopping using, observe 8 weeks cycles.

The employing Western medicine therapeutic alliance of diabetes is had, metformin hydrochloride tablet (Shanghai Shi Guibao pharmaceutical Co. Ltd of Sino-U.S. produces, 0.5 gram * 20/box) in matched group patient, each 0.25g, every day 3 times, oral after the meal, 4 courses for the treatment of Monday, observe 2 courses for the treatment of altogether; Benazepril hydrochloride contents in tablets (Novartis Pharma AG produces, 10mg*14s/ box), each 10mg, every day 1 time, 4 courses for the treatment of Monday, observes 2 courses for the treatment of altogether.

All cases, at treatments period, all require diet control, and participate in suitable physical training.Patient is regular weekly to be followed up a case by regular visits at special outpatient clinic, carries out clinical observation.

3.2 health giving quality observations

2 groups of patient view treat front and back fasting glucose (FBG), after the meal 2 hours blood glucoses (P2BG), serum total cholesterol (TC), triglyceride (TG), highdensity lipoprotein-cholesterol (HDL-C), LDL-C (LDL-C), blood pressure: measure weekly once and record, time is fixed, special messenger is responsible for, instrument, pressure value before treatment gets the intermediate value of first 3 days, then gets the peak for the treatment of and stopping in latter 5 days after treatment; Adverse reaction monitoring: the large conventional and hepatic and renal function for the treatment of before and after look 3, and record in therapeutic process with or without toxicity.

Every detection data with represent, and adopt t to check.

3.3 clinical efficacy criterion

Efficacy assessment standard: reference " traditional Chinese medical science Clinical Researches of New Drugs guideline " (Ministry of Health of the People's Republic of China. traditional Chinese medical science Clinical Researches of New Drugs guideline. second volume of [S] .1995.171-174.) middle related standards.

1. effective: clinical symptoms disappears substantially: blood fat, fasting glucose and after the meal 2 hours blood glucoses etc. improve more than 30% or reach normal value; Blood pressure reaches following any one person (1) diastolic pressure more than decline 10mmHg, and reaches normal range; (2) although diastolic pressure is for reaching normal, decline 20mmHg or more.

2. effective: treatment symptom is improved: blood fat, fasting glucose and after the meal 2 hours blood glucoses etc. improve more than 10%, but do not reach effective standard; Blood pressure reaches following any one person (1) diastolic pressure and declines not as good as 10mmHg, but reaches range of normal value; (2) diastolic pressure comparatively treats front decline 10-19mmHg, but does not reach range of normal value; (3) systolic pressure comparatively treats front more than decline 30mmHg.

3. invalid: after treatment, clinical symptoms is not improved, blood fat, fasting glucose and after the meal 2 hours blood glucoses etc. improve below 10%, blood pressure detecting systolic pressure comparatively treats front below decline 30mmHg or without improvement.

4, test results and analysis

The testing result of blood glucose, blood fat indices before and after table 12 groups of subject

The testing result of table 22 groups of subject's forward backward averaging pressure value indexs

Test example 2 present composition is to the clinical observation on the therapeutic effect of pure hypertension, hyperlipidemia, diabetes

1, object of study

Choose tested case 258 example of year July in April, 2010 to 2013 in Gate of Pervasive Peace Affiliated Hospital of Beijing University of Chinese Medicine, patient age 20-65 year, accept voluntarily to observe treatment.

Primary hypertension patient 94 example, wherein male patient 51 example, female patient 43 example.Be divided at random 2 groups (namely tested group, matched groups), often organize 47 examples;

Diabetics 96 example, wherein male patient 62 example, female patient 34 example.Be divided at random 2 groups (namely tested group, matched groups), often organize 48 examples;

Hyperlipemic patients 68 example, wherein male patient 43 example, female patient 25 example.Be divided at random 2 groups (namely tested group, matched groups), often organize 33 examples.

2 groups of cases there are no significant in sex, the course of disease, age distribution etc. difference, has comparability.

Wherein patient age is less than 20 years old, is greater than 65 years old; Be in gestation or women breast-feeding their children; Merge the serious diseases such as the heart, liver, kidney, brain; Other goods fat-reducing medicament of stopping using is being used to be discontented with the patient of 1 month not in this trial stretch.

2, case selection

The diagnosis of type Ⅱdiabetes mellitus meet 1997 ADA (ADA) standard (money is honourably obtained, diabetes clinical guidelines [M]. Beijing: publishing house of Beijing Medical University.2000.214-218)。Hyperlipidemia diagnosis reference " traditional Chinese medical science Clinical Researches of New Drugs guideline " (Ministry of Health of the People's Republic of China. traditional Chinese medical science Clinical Researches of New Drugs guideline. second volume of [S] .1995.171-174.) middle related standards: in normal diet situation, as 2 times are surveyed serum total cholesterol (TC) >=6.0mmol/L in 2 weeks, or serum levels of triglyceride (TG) >=1.54mmol/L or highdensity lipoprotein-cholesterol (HDL-C): male≤1.04mmol/L, women≤1.77mmol/L person.Hypertensive diagnosis meet WHO1999 announce " Hypertension Guideline " (WHO.1999 World Health Organization (WHO)/international hypertension alliance is about Treatment Guidelines for Hypertension [J]. hypertension magazine .1999. (7): 97-100) in hypertension definition and classification, criteria for classification.

3, Therapeutic Method

3.1 trial drugs and usage:

Tested group of other herbal three-hypers Yikang ball adopting the embodiment of the present invention 1 to prepare, every day 3 times, each 6 grams, equal half an hour ante cibum takes after mixing it with water, and other medicines of stopping using, observe 8 weeks cycles.

The patient only suffering from diabetes in matched group patient takes JIANGTANGSHU JIAONANG, and (Tian Tai Pharmaceutical limited company of Jilin Province produces, 0.3g*60 grain./ box), each 5, every day 3 times, oral after the meal, 4 courses for the treatment of Monday, observe 2 courses for the treatment of altogether; Only suffer from hypertensive patient and take Nifedipine Tablets (Zhongnuo Pharmaceutical (Shijiazhuang) Co., Ltd., Shiyao Group produces, 10mg*100 sheet/box), each 10mg, every day 3 times, 4 courses for the treatment of Monday, observe 2 courses for the treatment of altogether; The patient only suffering from hyperlipidemia takes lovastatin tablet (BeiJing WanSheng Pharmacy Co., Ltd's production), 20mg*10s/ box), each 10mg (half), every day 1 time, takes during dinner, 4 courses for the treatment of Monday, observes 2 courses for the treatment of altogether.

3.2 health giving quality observations

2 groups of patient view treat front and back fasting glucose (FBG), after the meal 2 hours blood glucoses (P2BG), serum total cholesterol (TC), triglyceride (TG), highdensity lipoprotein-cholesterol (HDL-C), LDL-C (LDL-C), blood pressure: measure weekly once and record, time is fixed, special messenger is responsible for, instrument, pressure value before treatment gets the intermediate value of first 3 days, then gets the peak for the treatment of and stopping in latter 5 days after treatment; Adverse reaction monitoring: the large conventional and hepatic and renal function for the treatment of before and after look 3, and record in therapeutic process with or without toxicity.

Every detection data with represent, and adopt t to check.

3.3 clinical efficacy criterion

3.3.1 hypertensive clinical efficacy criterion

1. effective: diastolic pressure more than decline 10mmHg, and reach normal range; (2) although diastolic pressure is for reaching normal, more than decline 20mmHg (possess above-mentioned any one); 2. effective: diastolic pressure declines not as good as 10mmHg, but reaches range of normal value; (2) diastolic pressure comparatively treats front decline 10-19mmHg, but does not reach range of normal value; (3) systolic pressure comparatively treats front more than decline 30mmHg (possess above-mentioned any one); 3. invalid: not reach above-mentioned standard.

3.3.2 the clinical efficacy criterion of diabetes

1. effective: treatment after symptom substantially disappear, fasting glucose < 7.0mmol/L, after the meal 2 hours blood glucose < 8.3mmol/L, glycolated hemoglobin and the full recovery of blood fat (TC, TG) laboratory indexes normal; 2. effective: after treatment, symptom is obviously improved, fasting glucose < 8.0mmol/L, after the meal 2 hours blood glucose < 10mmol/L, glycolated hemoglobin and blood fat (TC, TG) laboratory indexes makes moderate progress before comparatively treating, but does not recover normal; 3. invalid: after treatment, symptom is not improved, blood glucose, glycolated hemoglobin and blood fat (TC, TG) decline and do not reach above-mentioned standard.

3.3.3 the clinical efficacy criterion of hyperlipidemia

1. effective: TC declines >=20%; TG declines >=40%; HDL-C rising >=0.26mmol/L; LDL-C declines >=20% (possess above-mentioned any one); 2. effective: TC declines >=10%, but <20%; TG declines >=20%, but <40%; HDL-C rising >=0.104mmol/L, but <0.26mmol/L; LDL-C declines >=10%, but <20% (possess above-mentioned any one); 3. invalid: not reach above-mentioned standard.

4, test results and analysis

4.1 pure diabetics result of the tests

The testing result of blood glucose, post-prandial glycemia index before and after table 32 groups of pure diabetic subjects treatments

Therapeutic evaluation situation after the medication of table 42 groups of pure diabetic subjects

Group	Effective	Effectively	Invalid	Total effective rate (%)
					Tested group	41	5	2	95.8
Matched group	39	5	4	91.7

4.2 pure primary hypertension patient result of the tests

The testing result of blood markers before and after table 52 groups of pure essential hypertension subject

Therapeutic evaluation situation after the simple primary hypertension patient medication of 2 groups, table 6

Group	Effective	Effectively	Invalid	Total effective rate (%)
					Tested group	40	6	1	97.8

Matched group

38

5

4

91.5

4.3 pure hyperlipemic patients result of the tests

The testing result of blood lipids index before and after table 72 groups of simple hyperlipemia subject

Therapeutic evaluation situation after the medication of table 82 groups of pure hyperlipemic patients

Group	Effective	Effectively	Invalid	Total effective rate (%)
					Tested group	24	7	2	93.9
Matched group	21	9	3	90.9

Test example 3

Test method: choose 35 years old age and suffered from hyperlipidemia to 45 years old, hypercholesterolemia simultaneously, hypertension (low pressure 110mmHg, high pressure 160mmHg), patient 100 people of fatty liver is first tested group; Choose 50 years old age and suffered from hypertension to 65 years old, hyperlipidemia, heart disease simultaneously, patient 100 people of cerebral thrombosis (wherein, blood pressure low pressure 120mmHg, high pressure 180mmHg) is second tested group.2 to 3 months test periods, often organize everyone and take herbal three-hypers Yikang ball 3 times prepared by the embodiment of the present invention 1, each 6 grams, equal half an hour ante cibum takes after mixing it with water, and other medicines of stopping using.

Everyone takes blood test after 30 days continuously.Result of laboratory test shows: two groups of tested crowd's results are substantially identical, the blood fat of experimenter and cholesterol on average reduce by 1.2% and 0.8%, blood pressure is substantially steady, in two groups of experimenters only 3% because of work and diet can not the reason such as rule, the partner treatment and the Western medicine taken in the past when taking herbal three-hypers Yikang ball Chinese medicine of the present invention reduces by half.

Tested patients everyone take blood test after 60 days continuously, tested crowd's result of laboratory test display in 2nd month: the blood fat of more than 97% patient in first tested group, cholesterol index recovers normal completely, blood pressure, heart rate all replys normal level, advises its drug withdrawal, only have the patient of 3% due to the state of an illness heavier, though alleviate to some extent through symptom after taking medicine, still have symptom to feel, suggestion continues observation of taking medicine; The blood fat of more than 93% patient in second tested group, cholesterol is down to normally, carotid artery checks that blood speckle substantially disappears or disappears completely, it is normal that blood pressure enters this recovery, heart substantially without malaise symptoms, although there is patient's blood fat of 7%, cholesterol and carotid artery blood rubbish speckle all have reduction, blood pressure and heart disease comparatively before take a favorable turn, but still need take medicine, and consumption of taking medicine comparatively before reduces by half.

Observe the blood test result after 3 months, wherein take medicine in first tested group 2 months namely rehabilitation the patient of drug withdrawal no case was recurrence, the state of an illness heavier 3% experimenter, blood pressure, heart also all full recoveries after continuing to take medicine, without malaise symptoms, the every index of correlation of examination in hospital is all in normal range; In second tested group more than 87% patients with lipid, cholesterol, blood pressure recovers normal, and carotid atherosclerotic plaque disappears, heart without malaise symptoms, image check, heart recovers normal, although separately there is patient's blood fat of 13%, cholesterol is normally near; Blood pressure and heart disease improvement degree feel and reach more than 70%, but still can not withdraw medicine, need continue to strengthen.According to testing proof above, herbal three-hypers benefit sugar pill is not only to hypertension, and hyperlipidemia, hypercholesterolemia has remarkable result, and simultaneously to arteriosclerosis, cerebral thrombosis, heart disease also has great repair.

Above clinical efficacy result shows: Chinese medicine composition prepared by technical solution of the present invention is in treatment " three-hypers " disease, especially have obvious therapeutic effect to hypertension, hyperlipidemia, hyperglycemia and fatty liver conditions, each embodiment group medicine all has curing protrusion effect.Result shows, Chinese medicine composition of the present invention has the advantages such as preparation technology is scientific and reasonable, drug effect is clear and definite, stable curative effect is reliable, no matter its beneficial effect is from the treatment process of medicine, or on the forming technique of finished product preparation, all effectively ensure that the excellent results of Chinese medicine composition of the present invention, this proves further, Chinese medicine composition of the present invention is a kind of determined curative effect, prevent and treat " three-hypers " disease drug safely and effectively, there is huge market potential, be worth further genralrlization.

Test example 4 the present invention treatment " three-hypers " disease Chinese medicine composition toxicological test

(1) acute toxicity test

The Chinese medicine composition pill for the treatment of of the present invention " three-hypers " disease is gavaged 1000g (crude drug)/kg to kunming mice.There is not any toxic reaction, without animal dead in one week.

(2) long term toxicity test

The Chinese medicine composition pill for the treatment of of the present invention " three-hypers " disease is carried out long term toxicity test to rat, continuous heavy dose (100 times of adult human dose) gastric infusion, administration time long (90 days), with the general performance before and after animals administer, body weight, food ration, hematology and Biochemical Indices In Serum, routine urinalysis, bone marrow classification, organ weights, organ coefficient for Testing index, and be aided with the pathological examination that animal respectively organizes internal organs, the toxicity profile of overall merit medicine.The indices of result display rat is all normal.Histopathologic examination's result display, rat respectively organizes internal organs no abnormality seen.

In sum: the Chinese medicine composition toxicity for the treatment of of the present invention " three-hypers " disease is low, safety range is wide, and the Chinese medicine composition edible safety of the present invention's treatment " three-hypers " disease is reliable.

Further illustrate the preparation method of the present composition by the following examples.

Prepared by embodiment 1 present composition pill

1) raw material (unit: × 10g) is taken according to following proportioning

Radix Salviae Miltiorrhizae 15, Radix Notoginseng 10, Radix Polygoni Multiflori 15, Fructus Crataegi 20, Fructus Lycii 15, Semen Cassiae 15

2) by after medical material Radix Salviae Miltiorrhizae, Radix Polygoni Multiflori, Fructus Lycii, Semen Cassiae rinsing, be placed in Multifunctional Chinese medicine and extract still and mix homogeneously, add tap water and soak 2 hours, wherein, the ratio of the weight of the tap water added and the weight (dry weight) of medicinal material mixture is 8:1;

3) open multi-functional extraction still power supply to heat, be heated to 100 DEG C, keep constant temperature at this temperature to extract 2 hours, then filter, obtain first time extracting solution for subsequent use;

4) in filtering residue, add tap water, the ratio of the weight of the tap water added and the weight (dry weight) of medicinal material mixture is 6:1, heating extraction, keeps heating-up temperature to be extract 2 hours at 100 DEG C, filters and obtain second time extracting solution;

5) 2 extracting solution are merged to be placed in vacuum high energy evaporation concentrator carry out concentrating under reduced pressure, obtained Radix Salviae Miltiorrhizae-the Radix Polygoni Multiflori-Fructus Lycii-Semen Cassiae mixed concentrated liquid, wherein, the relative pressure of concentrating under reduced pressure be-0.07MPa (namely with an atmospheric pressure for 0, pressure when controlling concentrating under reduced pressure is-0.07MPa relative to an atmospheric pressure), be heated to 80 DEG C, the weight of mixed concentrated liquid is 0.6:1 with the ratio of the weight of medicinal material mixture, namely carries out being evaporated to 60% of crude drug in whole weight;

6) crude drug Fructus Crataegi, Radix Notoginseng are placed in respectively pulverizer to carry out pulverizing and sieving process, cross 200 mesh sieves, then mix homogeneously, obtained granularity is less than 200 object Fructus Crataegi-panax mixed fine powders;

Fructus Crataegi of the present invention, Radix Notoginseng adopt 100 mesh sieves to sieve after pulverizing, and the powder particle size after pulverizing is more thin better, selects 200 mesh sieves to be that example is described in the embodiment of the present invention.

7) Radix Salviae Miltiorrhizae-Radix Polygoni Multiflori-Fructus Lycii-Semen Cassiae mixed concentrated liquid is mixed with Fructus Crataegi-panax mixed fine powder, and stir, obtained Radix Salviae Miltiorrhizae-the Radix Polygoni Multiflori-Fructus Lycii-Semen Cassiae-Fructus Crataegi-panax mixed thing, then pharmaceutically acceptable adjuvant (such as potassium sorbate is added, consumption is 0.05%) and appropriate water, after mix homogeneously in pellet processing machine pill, obtain the Chinese medicine composition book on Chinese herbal medicine three-hypers Yikang ball for the treatment of of the present invention " three-hypers " disease.

By oral 3 times for each person every day after sampling quality inspection is qualified, each 6 grams, the consumption that children reduce by half is monthly pack a course for the treatment of.

Prepared by embodiment 2 present composition granule

1) raw material (unit: × 10g) is taken according to following proportioning

Radix Salviae Miltiorrhizae 20, Radix Notoginseng 10, Radix Polygoni Multiflori 10, Fructus Crataegi 20, Fructus Lycii 15, Semen Cassiae 10

2) by after medical material Radix Salviae Miltiorrhizae, Radix Polygoni Multiflori, Fructus Lycii, Semen Cassiae rinsing, be placed in Multifunctional Chinese medicine and extract still and mix homogeneously, add tap water and soak 1 hour, wherein, the ratio of the weight of the tap water added and the weight (dry weight) of medicinal material mixture is 7:1;

3) open multi-functional extraction still power supply to heat, be heated to 100 DEG C, keep constant temperature at this temperature to extract 3 hours, then filter, obtain first time extracting solution for subsequent use;

4) in filtering residue, add tap water, the ratio of the weight of the tap water added and the weight (dry weight) of medicinal material mixture is 7:1, heating extraction, keeps heating-up temperature to be extract 3 hours at 100 DEG C, filters and obtain second time extracting solution;

5) 2 extracting solution are merged to be placed in vacuum high energy evaporation concentrator carry out concentrating under reduced pressure, obtained Radix Salviae Miltiorrhizae-the Radix Polygoni Multiflori-Fructus Lycii-Semen Cassiae mixed concentrated liquid, wherein, the relative pressure of concentrating under reduced pressure be-0.05MPa (namely with an atmospheric pressure for 0, pressure when controlling concentrating under reduced pressure is-0.05MPa relative to an atmospheric pressure), be heated to 100 DEG C, the weight of mixed concentrated liquid is 0.5:1 with the ratio of the weight of medicinal material mixture, namely carry out being evaporated to Radix Salviae Miltiorrhizae, Radix Polygoni Multiflori, Fructus Lycii, Semen Cassiae 4 taste crude drug in whole weight 50%;

6) crude drug Fructus Crataegi, Radix Notoginseng are placed in respectively pulverizer to carry out pulverizing and sieving process, cross 200 mesh sieves, then mix homogeneously, obtained granularity is less than 200 object Fructus Crataegi-panax mixed fine powders;

7) Radix Salviae Miltiorrhizae-Radix Polygoni Multiflori-Fructus Lycii-Semen Cassiae mixed concentrated liquid is mixed with Fructus Crataegi-panax mixed fine powder, and stir, obtained Radix Salviae Miltiorrhizae-the Radix Polygoni Multiflori-Fructus Lycii-Semen Cassiae-Fructus Crataegi-panax mixed thing, then pharmaceutically acceptable adjuvant (such as microcrystalline Cellulose is added, 10% and food preservative potassium sorbate, 0.05%), in making granule after mix homogeneously, the Chinese medicine composition book on Chinese herbal medicine three-hypers Yikang granule for the treatment of of the present invention " three-hypers " disease is obtained.

Prepared by embodiment 3 present composition pill

1) raw material (unit: × 10g) is taken according to following proportioning

Radix Salviae Miltiorrhizae 10, Radix Notoginseng 10, Radix Polygoni Multiflori 20, Fructus Crataegi 20, Fructus Lycii 10, Semen Cassiae 25

2) by after medical material Radix Salviae Miltiorrhizae, Radix Polygoni Multiflori, Fructus Lycii, Semen Cassiae rinsing, be placed in Multifunctional Chinese medicine and extract still and mix homogeneously, add tap water and soak 3 hours, wherein, the ratio of the weight of the tap water added and the weight (dry weight) of medicinal material mixture is 6:1;

3) open multi-functional extraction still power supply to heat, be heated to 100 DEG C, keep constant temperature at this temperature to extract 1 hour, then filter, obtain first time extracting solution for subsequent use;

4) in filtering residue, add tap water, the ratio of the weight of the tap water added and the weight (dry weight) of medicinal material mixture is 5:1, heating extraction, keeps heating-up temperature to be extract 1 hour at 100 DEG C, filters and obtain second time extracting solution;

5) 2 extracting solution are merged to be placed in vacuum high energy evaporation concentrator carry out concentrating under reduced pressure, obtained Radix Salviae Miltiorrhizae-the Radix Polygoni Multiflori-Fructus Lycii-Semen Cassiae mixed concentrated liquid, wherein, the relative pressure of concentrating under reduced pressure be-0.095MPa (namely with an atmospheric pressure for 0, pressure when controlling concentrating under reduced pressure is-0.095MPa relative to an atmospheric pressure), be heated to 80 DEG C, the weight of mixed concentrated liquid is 0.4:1 with the ratio of the weight of medicinal material mixture, namely carries out being evaporated to 40% of crude drug in whole weight;

6) crude drug Fructus Crataegi, Radix Notoginseng are placed in respectively pulverizer to carry out pulverizing and sieving process, cross 200 mesh sieves, then mix homogeneously, obtained granularity is less than 200 object Fructus Crataegi-panax mixed fine powders;

7) Radix Salviae Miltiorrhizae-Radix Polygoni Multiflori-Fructus Lycii-Semen Cassiae mixed concentrated liquid is mixed with Fructus Crataegi-panax mixed fine powder, and stir, obtained Radix Salviae Miltiorrhizae-the Radix Polygoni Multiflori-Fructus Lycii-Semen Cassiae-Fructus Crataegi-panax mixed thing, then pharmaceutically acceptable adjuvant (such as potassium sorbate is added, consumption is 0.05%) and appropriate water, after mix homogeneously in pellet processing machine pill, obtain the Chinese medicine composition book on Chinese herbal medicine three-hypers Yikang ball for the treatment of of the present invention " three-hypers " disease.

Prepared by embodiment 4 present composition capsule

1) raw material (unit: × 10g) is taken according to following proportioning

Radix Salviae Miltiorrhizae 35, Radix Notoginseng 10, Radix Polygoni Multiflori 30, Fructus Crataegi 10, Fructus Lycii 15, Semen Cassiae 30

2) by after medical material Radix Salviae Miltiorrhizae, Radix Polygoni Multiflori, Fructus Lycii, Semen Cassiae rinsing, be placed in Multifunctional Chinese medicine and extract still and mix homogeneously, add tap water and soak 2 hours, wherein, the ratio of the weight of the tap water added and the weight (dry weight) of medicinal material mixture is 8:1;

3) open multi-functional extraction still power supply to heat, be heated to 100 DEG C, keep constant temperature at this temperature to extract 2 hours, then filter, obtain first time extracting solution for subsequent use;

4) in filtering residue, add tap water, the ratio of the weight of the tap water added and the weight (dry weight) of medicinal material mixture is 6:1, heating extraction, keeps heating-up temperature to be extract 2 hours at 100 DEG C, filters and obtain second time extracting solution;

5) 2 extracting solution are merged to be placed in vacuum high energy evaporation concentrator carry out concentrating under reduced pressure, obtained Radix Salviae Miltiorrhizae-the Radix Polygoni Multiflori-Fructus Lycii-Semen Cassiae mixed concentrated liquid, wherein, the relative pressure of concentrating under reduced pressure be-0.07MPa (namely with an atmospheric pressure for 0, pressure when controlling concentrating under reduced pressure is-0.07MPa relative to an atmospheric pressure), be heated to 80 DEG C, the weight of mixed concentrated liquid is 0.7:1 with the ratio of the weight of medicinal material mixture, namely carries out being evaporated to 70% of crude drug in whole weight;

6) crude drug Fructus Crataegi, Radix Notoginseng are placed in respectively pulverizer to carry out pulverizing and sieving process, cross 200 mesh sieves, then mix homogeneously, obtained granularity is less than 200 object Fructus Crataegi-panax mixed fine powders;

7) Radix Salviae Miltiorrhizae-Radix Polygoni Multiflori-Fructus Lycii-Semen Cassiae mixed concentrated liquid is mixed with Fructus Crataegi-panax mixed fine powder, and stir, obtained Radix Salviae Miltiorrhizae-the Radix Polygoni Multiflori-Fructus Lycii-Semen Cassiae-Fructus Crataegi-panax mixed thing, then pharmaceutically acceptable adjuvant (microcrystalline Cellulose 10% and potassium sorbate 0.5%) is added, dry after mix homogeneously, obtain the Chinese medicine composition book on Chinese herbal medicine three-hypers Yikang capsules for the treatment of of the present invention " three-hypers " disease in incapsulating.

Prepared by embodiment 5 present composition pill

1) raw material (unit: × 10g) is taken according to following proportioning

Radix Salviae Miltiorrhizae 5, Radix Notoginseng 20, Radix Polygoni Multiflori 5, Fructus Crataegi 30, Fructus Lycii 25, Semen Cassiae 7

2) by after medical material Radix Salviae Miltiorrhizae, Radix Polygoni Multiflori, Fructus Lycii, Semen Cassiae rinsing, be placed in Multifunctional Chinese medicine and extract still and mix homogeneously, add tap water and soak 2 hours, wherein, the ratio of the weight of the tap water added and the weight (dry weight) of medicinal material mixture is 8:1;

3) open multi-functional extraction still power supply to heat, be heated to 100 DEG C, keep constant temperature at this temperature to extract 3 hours, then filter, obtain first time extracting solution for subsequent use;

4) in filtering residue, add tap water, the ratio of the weight of the tap water added and the weight (dry weight) of medicinal material mixture is 6:1, heating extraction, keeps heating-up temperature to be extract 3 hours at 100 DEG C, filters and obtain second time extracting solution;

5) 2 extracting solution are merged to be placed in vacuum high energy evaporation concentrator carry out concentrating under reduced pressure, obtained Radix Salviae Miltiorrhizae-the Radix Polygoni Multiflori-Fructus Lycii-Semen Cassiae mixed concentrated liquid, wherein, the relative pressure of concentrating under reduced pressure be-0.07MPa (namely with an atmospheric pressure for 0, pressure when controlling concentrating under reduced pressure is-0.07MPa relative to an atmospheric pressure), be heated to 80 DEG C, the weight of mixed concentrated liquid is 0.6:1 with the ratio of the weight of medicinal material mixture, namely carries out being evaporated to 60% of crude drug in whole weight;

6) crude drug Fructus Crataegi, Radix Notoginseng are placed in respectively pulverizer to carry out pulverizing and sieving process, cross 200 mesh sieves, then mix homogeneously, obtained granularity is less than 200 object Fructus Crataegi-panax mixed fine powders;

7) Radix Salviae Miltiorrhizae-Radix Polygoni Multiflori-Fructus Lycii-Semen Cassiae mixed concentrated liquid is mixed with Fructus Crataegi-panax mixed fine powder, and stir, obtained Radix Salviae Miltiorrhizae-the Radix Polygoni Multiflori-Fructus Lycii-Semen Cassiae-Fructus Crataegi-panax mixed thing, then pharmaceutically acceptable adjuvant (such as potassium sorbate is added, consumption is 0.05%) and appropriate water, after mix homogeneously in pellet processing machine pill, obtain the Chinese medicine composition book on Chinese herbal medicine three-hypers Yikang ball for the treatment of of the present invention " three-hypers " disease.

Claims (10)

1. treat a compositions for the Chinese medicine of " three-hypers " disease, it is characterized in that comprising following raw material: Radix Salviae Miltiorrhizae, Radix Notoginseng, the Radix Polygoni Multiflori, Fructus Crataegi, Fructus Lycii, Semen Cassiae.

2. compositions as claimed in claim 1, is characterized in that the weight of described crude drug is: Radix Salviae Miltiorrhizae 5-35, Radix Notoginseng 7-20, Radix Polygoni Multiflori 5-30, Fructus Crataegi 10-30, Fructus Lycii 10-25, Semen Cassiae 7-30.

3. compositions as claimed in claim 1 or 2, is characterized in that the weight of described crude drug is preferably: Radix Salviae Miltiorrhizae 10-20, Radix Notoginseng 10-15, Radix Polygoni Multiflori 10-20, Fructus Crataegi 20-30, Fructus Lycii 10-15, Semen Cassiae 10-25.

4. compositions as claimed in claim 3, is characterized in that the weight of described crude drug is: Radix Salviae Miltiorrhizae 15, Radix Notoginseng 10, the Radix Polygoni Multiflori 15, Fructus Crataegi 20, Fructus Lycii 15, Semen Cassiae 15.

5. treat a preparation method for the compositions of the Chinese medicine of " three-hypers " disease, comprise the steps:

1) raw material is prepared according to following weight:

Radix Salviae Miltiorrhizae 5-35, Radix Notoginseng 7-20, Radix Polygoni Multiflori 5-30, Fructus Crataegi 10-30, Fructus Lycii 10-25, Semen Cassiae 7-30

2) by after Radix Salviae Miltiorrhizae, Radix Polygoni Multiflori, Fructus Lycii and Semen Cassiae mix homogeneously, heating extraction is carried out to mixed material medicine, collect extracting solution;

3) concentration is carried out to the extracting solution collected, obtained Radix Salviae Miltiorrhizae-Radix Polygoni Multiflori-Fructus Lycii-Semen Cassiae concentrated solution;

4) crude drug Fructus Crataegi, Radix Notoginseng are carried out pulverization process, obtained Fructus Crataegi fine powder, Radix Notoginseng fine powder;

5) Fructus Crataegi fine powder, Radix Notoginseng fine powder and Radix Salviae Miltiorrhizae-Radix Polygoni Multiflori-Fructus Lycii-Semen Cassiae concentrated solution are mixed, to obtain final product.

6. preparation method as claimed in claim 5, is characterized in that, step 2) described in heating extraction comprise the step that following order carries out:

A) mixture of Radix Salviae Miltiorrhizae, Radix Polygoni Multiflori, Fructus Lycii and Semen Cassiae is added water soaking, the weight of the water added is 6-8:1 with the ratio of the weight of mixture, soak and carry out first time heating extraction after 1-3 hour, heating-up temperature is 100 DEG C, under maintenance temperature is the condition of 100 DEG C, extract 1-3 hour;

B) first time extracting solution is filtered, collect filtrate;

C) in filtering residue, add water, carry out second time heating extraction, wherein, the weight of the water added is 5-7:1 with the ratio of the weight of mixture, and heating-up temperature is 100 DEG C, under maintenance temperature is the condition of 100 DEG C, extract 1-3 hour;

D) filter, the filtrate of twice filtration is merged.

7. preparation method as claimed in claim 6, is characterized in that, steps A) described in heating extraction time 2 h, the weight of the water added is preferably 8:1 with the ratio of the weight of mixture; Step C) in the weight of water that adds be 6:1 with the ratio of the weight of mixture.

8. the preparation method as described in claim 5 or 6, is characterized in that, step 3) described in filtrate concentration process in control temperature be 80-100 DEG C, relative pressure is lower than-0.05MPa.

9. the preparation method as described in claim 5 or 6, is characterized in that, step 3) described in the weight of concentrated solution be 0.4-0.7:1 with the ratio of the gross weight of crude drug Radix Salviae Miltiorrhizae, Radix Polygoni Multiflori, Fructus Lycii and Semen Cassiae.

10. treat the application of compositions in preparation treatment hypertension, hyperlipidemia, diabetes medicament and health product of the Chinese medicine of " three-hypers " disease as claimed in claim 1 for one kind.