CN105213758A - A kind of Chinese medicine composition for the treatment of chronic pneumonia and preparation method thereof - Google Patents
A kind of Chinese medicine composition for the treatment of chronic pneumonia and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine composition for the treatment of chronic pneumonia and preparation method thereof, belong to technical field of Chinese medicines.Described a kind of Chinese medicine composition for the treatment of chronic pneumonia, be made up of the raw material of the adjuvant pharmaceutically commonly used and following weight portion: Radix Astragali 15-20 part, Carapax Trionycis 15-20 part, Poria 10-20 part, Radix Bupleuri 10-20 part, Radix Paeoniae 10-20 part, Ramulus Cinnamomi 10-15 part, Pericarpium Citri Reticulatae 10-15 part, Rhizoma Atractylodis Macrocephalae 10-15 part, Radix Rehmanniae 10-15 part, Bulbus Fritillariae Uninbracteatae shellfish river 10-15 part, Radix Platycodonis 10-15 part, Semen Armeniacae Amarum 10-15 part, Radix Ginseng 5-10 part, Radix Glycyrrhizae 5-15 part, then be prepared from through processing technology disclosed by the invention.The present invention is made up of 13 taste medicines, and by mutual collaborative promotion again between each flavour of a drug, balance, the good relief of symptoms of energy, cure rate are high, and treatment cycle is short and side effect is little, has actual application value and major and immediate significance.
Description
Technical field
The present invention relates to technical field of Chinese medicines, is a kind of Chinese medicine composition for the treatment of chronic pneumonia and preparation method thereof specifically.
Background technology
Pneumonia, refers to that the symptom of inflammation appears in the alveolar of pulmonary, and the course of disease is chronic pneumonia more than 3 months persons.Chronic pneumonia easily periodically recurs and worsens, and passes through in undaform.Due to the difference of period of pathological changes, age and individuality, symptom is varied.Resting stage body temperature normal, without obvious sign, almost do not cough, but easily pant when running and upstairs.In the deterioration phase often with pulmonary insufficiency, there is cyanosis and dyspnea, and due to vital capacity and breathing reserve minimizing and breath holding time shortening etc., cause the external respiration dysfunction of hyperventilation.Taking a turn for the better after worsening very slow, even there is puffiness of face, cyanosis, thoracic deformity and drumstick finger, toe in frequent expectoration.Due to emphysema, pulmonary insufficiency and cause pulmonary vascular resistance to increase, pulmonary artery pressure increases, right heart burden, can in half a year in two years pulmonary heart disease occur.Also hepatic insufficiency may be had.Leukocyte increases, and erythrocyte sedimentation rate moderate speeds.X-ray chest films showed is marched off into political wilderness in two lungs and hilus pulumonis district lung marking in cellular, can occur little panacinar emphysema, simultaneously also can with substantive inflammation foci.Hilar shadow visible symmetry in both sides increases.Also can there is the x-ray sign of the pulmonary heart disease such as bronchiectasis, right ventricular hypertrophy and pulmonary artery section are outstanding in the development with pathological changes.
At present, the medicine for the treatment of this disease mostly is the medicine of antiviral class, antibiotic infection control is applied during repeated infection, adrenocortical hormone also can play Inhibiting proliferation and promote the effect that focus is breathed, in addition electromagnetic therapy, ultrashort wave diathermy, massage and mustard apply etc. the auxiliary treatment such as physiotherapy.But, above Therapeutic Method DeGrain, and easily recur, the medicine of a large amount of antibiotics also has certain injury to human body.
The traditional Chinese medical science is thought, chronic pneumonia belongs to pyretic pulmonary disease, and as heavy cold, pulmonary tuberculosis, bronchitis, chronic malaria etc. can cause the symptom such as chronic cough, remittent fever, clear heat dissipation, slowly development forms chronic pneumonia.Therefore, treatment chronic pneumonia should be set about from heat clearing away, QI invigorating, the many-side such as to invigorate blood circulation, also for this disease for the treatment of proposes a kind of new thinking.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of Chinese medicine composition for the treatment of chronic pneumonia and preparation method thereof, is made up of the raw material of the adjuvant pharmaceutically commonly used and following weight portion: Radix Astragali 15-20 part, Carapax Trionycis 15-20 part, Poria 10-20 part, Radix Bupleuri 10-20 part, Radix Paeoniae 10-20 part, Ramulus Cinnamomi 10-15 part, Pericarpium Citri Reticulatae 10-15 part, Rhizoma Atractylodis Macrocephalae 10-15 part, Radix Rehmanniae 10-15 part, Bulbus Fritillariae Uninbracteatae shellfish river 10-15 part, Radix Platycodonis 10-15 part, Semen Armeniacae Amarum 10-15 part, Radix Ginseng 5-10 part, Radix Glycyrrhizae 5-15 part.
As preferred technical scheme, described a kind of Chinese medicine composition for the treatment of chronic pneumonia, is made up of the raw material of the adjuvant pharmaceutically commonly used and following weight portion: the Radix Astragali 17 parts, Carapax Trionycis 17 parts, 15 parts, Poria, Radix Bupleuri 15 parts, Radix Paeoniae 15 parts, Ramulus Cinnamomi 13 parts, Pericarpium Citri Reticulatae 13 parts, the Rhizoma Atractylodis Macrocephalae 13 parts, the Radix Rehmanniae 13,13 parts, Bulbus Fritillariae Uninbracteatae shellfish river, Radix Platycodonis 13 parts, Semen Armeniacae Amarum 13 parts, Radix Ginseng 8 parts, 10 parts, Radix Glycyrrhizae.
As preferred technical scheme, described a kind of Chinese medicine composition tablet, capsule, pill, granule for the treatment of chronic pneumonia.
Present invention also offers above-mentioned preparation method, comprise the following steps:
(1) Radix Astragali, Carapax Trionycis, Poria, Radix Bupleuri, Radix Paeoniae, Ramulus Cinnamomi, Pericarpium Citri Reticulatae, the Rhizoma Atractylodis Macrocephalae, the Radix Rehmanniae, Bulbus Fritillariae Uninbracteatae Bei Chuan, Radix Platycodonis, Semen Armeniacae Amarum, Radix Ginseng, Radix Glycyrrhizae is taken, for subsequent use;
(2) medical material weighed up is added soak by water 2-3 time of 3-5 times of weight, each 1-2 hour, filter;
(3) filtrate in step (2) is merged, in the filtrate merged, add the ethanol of 90%, and concentrated under the condition of steam pressure≤0.20Mpa, vacuum≤-0.10Mpa;
(4) by the medicinal liquid reflux, extract, after concentrated in step (3) 2 times, and then add the alcohol reflux 2 times of 75%, reclaim ethanol and consider liquid;
(5) the ethanol filtrate cold drying of will reclaim, pulverizes, adds pharmaceutically acceptable adjuvant, and mixing, makes medicament.
Adjuvant pharmaceutically conventional is in the present invention selected from one or more in filler, binding agent, disintegrating agent, lubricant, surfactant or correctives.
Purposes in the medicine of the hectic fever due to YIN-deficiency that the Chinese medicine composition that the present invention is a kind of treats chronic pneumonia causes in preparation treatment pulmonary tuberculosis, chronic pneumonia, chronic bronchitis, chronic malaria, pulmonary tuberculosis.
The property of medicine of crude drug that the present invention adopts, pharmacology and effect are as follows:
The Radix Astragali: sweet in the mouth slightly warm in nature.Return lung, spleen, liver, kidney channel.Polishing consolidating superficial resistance, holder skin ulcer granulation promoting.Cure mainly the empty spontaneous perspiration of body, chronic diarrhea, proctoptosis, uterine prolapse, chronic nephritis, body is impractical swollen, chronic ulcer, open sore part disunion of a specified duration.The life Radix Astragali, has effect of benefiting QI for strengthening the superficies, inducing diuresis to remove edema, detoxification, granulation promoting.
Carapax Trionycis: salty in the mouth, property is put down.Effect: nourishing YIN for suppressing the hyperactive YANG, hard masses softening and resolving.
Poria: sweet in the mouth, light, property are put down, can eliminating dampness and diuresis; Invigorating the spleen and regulating the stomach; Mind tranquilizing and the heart calming.Cure mainly dysuria; Edema distension; Phlegm retention cough with dyspnea; Vomiting; Insufficiency of the spleen lack of appetite; Have loose bowels; Palpitation and restlessness; Insomnia forgetfulness; Seminal emission nebulousurine.
Radix Bupleuri: induce sweat and bring down a fever; Dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy.Main fever caused by exogenous pathogens; Alternate attack of chill and fever; Malaria; Hypochondriac pain due to stagnation of liverQI mammary swelling; Headache dizziness; Menoxenia; The proctoptosis of collapse of QI; Uterine prolapse; Gastroptosis.
Radix Paeoniae: there is spasmolytic, ease pain, the effect of stimulating the menstrual flow.The disease such as right stomachache, stomach spasm, dizzy, gout, diuresis is effective.
Ramulus Cinnamomi: acrid in the mouth, sweet, warm in nature; GUIXIN, lung, urinary bladder channel.Diaphoresis expelling pathogenic factors from muscles, warming the meridian and promoting blood circulation.Control exterior syndrome due to wind-cold, shoulder back of the body podomere ache, thoracic obstruction phlegm retention, amenorrhea lump in the abdomen.
The Rhizoma Atractylodis Macrocephalae: there is air making-up and spleen enlivening, dampness diuretic, hidroschesis, antiabortive effect.
The Radix Rehmanniae: removing heat from blood YIN nourishing.
Bulbus Fritillariae Uninbracteatae Bei Chuan: lung moistening eliminating stagnation, antitussive reduces phlegm.Control cough due to consumptive disease, spitting of blood of spitting, ambition pent-up, consumptive lung disease, lung abscess, goiter, honest and clean scrofula, sore throat, acute mastitis.
Radix Platycodonis: property is flat, bitter in the mouth, pungent, slightly poisonous.Attach to the lung and stomach meridians.Have eliminate the phlegm, sore-throat relieving, lung qi dispersing, evacuation of pus, sharp the five internal organs, the effect that fills blood.
Semen Armeniacae Amarum: the effect such as have anti-inflammatory and antalgic, relieving asthma, has anticancer, blood sugar lowering, blood fat reducing and the effects such as beauty treatment.
Radix Ginseng: property is flat, sweet in the mouth, micro-hardship, tepor.Return spleen, lung meridian.Effect: strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, invigorating the spleen to benefit the lung, promoting the production of body fluid to quench thirst, Fructus Alpiniae Oxyphyllae of calming the nerves.Cure mainly: impairment caused by overstrain is deficient, food is told in lack of appetite, asthenia, regurgitation, stool lingering diarrhea, empty cough with asthma are short, spontaneous perspiration sudden collapse, palpitation with fear, forgetful, dizziness and headache, sexual impotence, frequent micturition, quench one's thirst, woman uterine bleeding, children's's intermittent infantile convulsion and prolonged deficiency be multiple, the card of all qi-blood-body fluid deficiencies.
Radix Glycyrrhizae: nature and flavor are sweet flat, GUIXIN, lung, spleen, stomach warp.The merit of tool invigorating the spleen and replenishing QI, nourishing the lung to arrest cough, relieving spasm to stop pain, the mitigation property of medicine.
According to the general layout of the traditional Chinese medical science, Chinese medicine determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, monarch, scientific compatibility is carried out to above-mentioned Chinese medicine and proposes effective drug regimen, be made up of 13 taste medicines as the present invention, can nourishing kidney, separate Liver Channel and lung meridian stagnant heat, wherein, the Radix Rehmanniae, Semen Armeniacae Amarum and Bulbus Fritillariae Uninbracteatae river mother separate lung-heat, and Bulbus Fritillariae Uninbracteatae river mother can relieving cough and resolving phlegm; Radix Bupleuri and Radix Paeoniae solution liver-heat, and Radix Paeoniae can be invigorated blood circulation; Consolidating superficial resistance QI invigorating, the spleen reinforcing such as the Radix Astragali, Poria, Radix Bupleuri, Ramulus Cinnamomi, Radix Ginseng, Radix Glycyrrhizae, enter lung meridian, Ramulus Cinnamomi and Pericarpium Citri Reticulatae can be regulated the flow of vital energy, Poria diuresis.By mutual collaborative promotion again between each flavour of a drug, balance, the good relief of symptoms of energy, cure rate are high, and treatment cycle is short and side effect is little, has actual application value and major and immediate significance.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described further.
embodiment 1
Take Radix Astragali 150g, Carapax Trionycis 150g, Poria 100g, Radix Bupleuri 100g, Radix Paeoniae 100g, Ramulus Cinnamomi 100g, Pericarpium Citri Reticulatae 100g, Rhizoma Atractylodis Macrocephalae 100g, Radix Rehmanniae 100g, Bulbus Fritillariae Uninbracteatae shellfish river 100g, Radix Platycodonis 100g, Semen Armeniacae Amarum 100g, Radix Ginseng 50g, Radix Glycyrrhizae 50g, add the soak by water 2 times of 5 times of weight, each 2 hours, filter; Filtrate merges, and adds the ethanol of 90% in the filtrate merged, and concentrated under the condition of steam pressure≤0.20Mpa, vacuum≤-0.10Mpa; By the medicinal liquid reflux, extract, after concentrated 2 times, and then add the alcohol reflux 2 times of 75%, reclaim ethanol and consider liquid.By the ethanol filtrate cold drying of reclaiming, pulverize, add pharmaceutically acceptable adjuvant, pill after mix homogeneously, cold drying, granulate, packaging, obtain compositions of the present invention, it is pill.
embodiment 2
Take Radix Astragali 170g, Carapax Trionycis 170g, Poria 150g, Radix Bupleuri 150g, Radix Paeoniae 150g, Ramulus Cinnamomi 130g, Pericarpium Citri Reticulatae 130g, Rhizoma Atractylodis Macrocephalae 130g, Radix Rehmanniae 130g, Bulbus Fritillariae Uninbracteatae shellfish river 130g, Radix Platycodonis 130g, Semen Armeniacae Amarum 130g, Radix Ginseng 80g, Radix Glycyrrhizae 100g, add the soak by water 2 times of 4 times of weight, each 1.5 hours, filter; Filtrate merges, and adds the ethanol of 90% in the filtrate merged, and concentrated under the condition of steam pressure≤0.20Mpa, vacuum≤-0.10Mpa; By the medicinal liquid reflux, extract, after concentrated 2 times, and then add the alcohol reflux 2 times of 75%, reclaim ethanol and consider liquid.By the ethanol filtrate cold drying of reclaiming, pulverize, add pharmaceutically acceptable adjuvant, film-making after mix homogeneously, cold drying, tabletting, packaging, obtain compositions of the present invention, it is tablet form.
embodiment 3
Take Radix Astragali 180g, Carapax Trionycis 180g, Poria 160g, Radix Bupleuri 160g, Radix Paeoniae 160g, Ramulus Cinnamomi 140g, Pericarpium Citri Reticulatae 140g, Rhizoma Atractylodis Macrocephalae 140g, Radix Rehmanniae 140g, Bulbus Fritillariae Uninbracteatae shellfish river 140g, Radix Platycodonis 140g, Semen Armeniacae Amarum 140g, Radix Ginseng 90g, Radix Glycyrrhizae 120g, add the soak by water 3 times of 3 times of weight, each 1 hour, filter; Filtrate merges, and adds the ethanol of 90% in the filtrate merged, and concentrated under the condition of steam pressure≤0.20Mpa, vacuum≤-0.10Mpa; By the medicinal liquid reflux, extract, after concentrated 2 times, and then add the alcohol reflux 2 times of 75%, reclaim ethanol and consider liquid.By the ethanol filtrate cold drying of reclaiming, pulverize, add pharmaceutically acceptable adjuvant, granulate after mix homogeneously, cold drying, granulate, packaging, obtain compositions of the present invention, it is Capsule form.
embodiment 4
Take Radix Astragali 200g, Carapax Trionycis 200g, Poria 200g, Radix Bupleuri 200g, Radix Paeoniae 200g, Ramulus Cinnamomi 150g, Pericarpium Citri Reticulatae 150g, Rhizoma Atractylodis Macrocephalae 150g, Radix Rehmanniae 150g, Bulbus Fritillariae Uninbracteatae shellfish river 150g, Radix Platycodonis 150g, Semen Armeniacae Amarum 150g, Radix Ginseng 100g, Radix Glycyrrhizae 150g, add the soak by water 2 times of 5 times of weight, each 2 hours, filter; Filtrate merges, and adds the ethanol of 90% in the filtrate merged, and concentrated under the condition of steam pressure≤0.20Mpa, vacuum≤-0.10Mpa; By the medicinal liquid reflux, extract, after concentrated 2 times, and then add the alcohol reflux 2 times of 75%, reclaim ethanol and consider liquid.By the ethanol filtrate cold drying of reclaiming, pulverize, add pharmaceutically acceptable adjuvant, granulate after mix homogeneously, cold drying, granulate, packaging, obtain compositions of the present invention, it is granular form.
Medicine pharmacy and clinical trial
1, acute toxicity test:
Embodiment 1-3 gained medicament is pulverized respectively, is dissolved in appropriate pure water, be mixed with the suspension that concentration is 2.5g/ml; Choose cleaning grade Kunming mouse 40, male and female half and half, body weight 18 ~ 22g, be divided into two groups at random, be respectively test group and matched group, often organize 20, male and female sub-cage rearing, rearing conditions: temperature 20 ~ 24 DEG C, relative humidity 40% ~ 60%, adopts manually round the clock, early 6 extremely 6 illumination in evening, all the other 12 h dark, freely drink water, without feed; Overdose gastric infusion is carried out to test group mice, administration concentration is 45ml/kg, gavage three times in 24h, every minor tick 6h, the administration concentration of test group is 100g/kg, this dosage is 5000 times of the daily dosage (0.02g/kg) of being equivalent to be grown up, and matched group gives distilled water according to same method with dosage, Continuous Observation 7 days;
Observed result: test group mice administration first day, comparatively control group mice activity reduces, and normally, after second day, outward appearance, excretion etc. are all normal for outward appearance, excretion;
Conclusion: the maximum administration concentration of test group mice is 100g/kg(LD
50>100g/kg), this dosage is 5000 times of the daily dosage (0.02g/kg) of being equivalent to be grown up, but mice none is dead, behavior is normal, points out this Chinese medicine preparation toxicity extremely low, clinical drug safety.
Long-term Clinical Observation
Inventor once repeatedly changed prescription of the present invention, was finally defined as compatible combination disclosed by the invention, and the nearly 300 many cases patients of sequential treatment, through follow-up investigation statistics for many years, medication initial stage effective percentage reaches 98%, and after adhering to treatment, cure rate is up to more than 94%.Due to patient itself, some patient does not adhere to successional taking medicine, and has not yet fully recovered so far, but Be very effective.By observation in recent years, almost there is no toxic and side effects, patient do not occur disease relapse or other etc. symptom.
The equipment used in the present invention is the common equipment of this area, does not repeat them here.
The foregoing is only the schematic detailed description of the invention of the present invention, and be not used to limit scope of the present invention.Any those skilled in the art, equivalent variations done under the prerequisite not departing from design of the present invention and principle and amendment, all should belong to the scope of protection of the invention.
Claims (6)
1. treat the Chinese medicine composition of chronic pneumonia for one kind, it is characterized in that, be made up of the raw material of the adjuvant pharmaceutically commonly used and following weight portion: Radix Astragali 15-20 part, Carapax Trionycis 15-20 part, Poria 10-20 part, Radix Bupleuri 10-20 part, Radix Paeoniae 10-20 part, Ramulus Cinnamomi 10-15 part, Pericarpium Citri Reticulatae 10-15 part, Rhizoma Atractylodis Macrocephalae 10-15 part, Radix Rehmanniae 10-15 part, Bulbus Fritillariae Uninbracteatae shellfish river 10-15 part, Radix Platycodonis 10-15 part, Semen Armeniacae Amarum 10-15 part, Radix Ginseng 5-10 part, Radix Glycyrrhizae 5-15 part.
2. treat the Chinese medicine composition of chronic pneumonia for one kind, it is characterized in that, be made up of the raw material of the adjuvant pharmaceutically commonly used and following weight portion: the Radix Astragali 17 parts, Carapax Trionycis 17 parts, 15 parts, Poria, Radix Bupleuri 15 parts, Radix Paeoniae 15 parts, Ramulus Cinnamomi 13 parts, Pericarpium Citri Reticulatae 13 parts, the Rhizoma Atractylodis Macrocephalae 13 parts, the Radix Rehmanniae 13,13 parts, Bulbus Fritillariae Uninbracteatae shellfish river, Radix Platycodonis 13 parts, Semen Armeniacae Amarum 13 parts, Radix Ginseng 8 parts, 10 parts, Radix Glycyrrhizae.
3. a kind of Chinese medicine composition for the treatment of chronic pneumonia according to claim 1 and 2, is characterized in that, said composition is tablet, capsule, pill, granule.
4. a kind of Chinese medicine composition for the treatment of chronic pneumonia and preparation method thereof as claimed in claim 1 or 2, preparation method, it is characterized in that, comprise the following steps:
(1) Radix Astragali, Carapax Trionycis, Poria, Radix Bupleuri, Radix Paeoniae, Ramulus Cinnamomi, the Rhizoma Atractylodis Macrocephalae, the Radix Rehmanniae, Bulbus Fritillariae Uninbracteatae Bei Chuan, Radix Platycodonis, Semen Armeniacae Amarum, Radix Ginseng, Radix Glycyrrhizae is taken, for subsequent use;
(2) medical material weighed up is added soak by water 2-3 time of 3-5 times of weight, each 1-2 hour, filter;
(3) filtrate in step (2) is merged, in the filtrate merged, add the ethanol of 90%, and concentrated under the condition of steam pressure≤0.20Mpa, vacuum≤-0.10Mpa;
(4) by the medicinal liquid reflux, extract, after concentrated in step (3) 2 times, and then add the alcohol reflux 2 times of 75%, reclaim ethanol and consider liquid;
(5) the ethanol filtrate cold drying of will reclaim, pulverizes, adds pharmaceutically acceptable adjuvant, and mixing, makes medicament.
5. a kind of Chinese medicine composition for the treatment of chronic pneumonia according to claim 1 and 2, is characterized in that, described pharmaceutically conventional adjuvant is be selected from one or more in filler, binding agent, disintegrating agent, lubricant, surfactant or correctives.
6. the purposes in the medicine of the hectic fever due to YIN-deficiency that the Chinese medicine composition that a kind of according to claim 1-2 treats chronic pneumonia causes in preparation treatment pulmonary tuberculosis, chronic pneumonia, chronic bronchitis, chronic malaria, pulmonary tuberculosis.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107174629A (en) * | 2016-08-03 | 2017-09-19 | 李欣 | The foster lung of chronic pneumonia is slow to cough Chinese medicine |
| CN111467459A (en) * | 2020-03-31 | 2020-07-31 | 西安市中医医院 | Traditional Chinese medicine composition for treating novel coronavirus pneumonia at recovery stage, application and preparation method thereof |
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| CN103520694A (en) * | 2013-10-25 | 2014-01-22 | 梁轶聪 | Traditional Chinese medicine composition capable of treating chronic obstructive pulmonary disease in stabilization period and preparation method of composition |
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2015
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103520694A (en) * | 2013-10-25 | 2014-01-22 | 梁轶聪 | Traditional Chinese medicine composition capable of treating chronic obstructive pulmonary disease in stabilization period and preparation method of composition |
Non-Patent Citations (1)
| Title |
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| 刘五一等: "清热活血化癖治疗慢性肺炎21 例疗效分析", 《实用医学杂志》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107174629A (en) * | 2016-08-03 | 2017-09-19 | 李欣 | The foster lung of chronic pneumonia is slow to cough Chinese medicine |
| CN111467459A (en) * | 2020-03-31 | 2020-07-31 | 西安市中医医院 | Traditional Chinese medicine composition for treating novel coronavirus pneumonia at recovery stage, application and preparation method thereof |
| CN111467459B (en) * | 2020-03-31 | 2021-07-23 | 西安市中医医院 | Traditional Chinese medicine composition for treating novel coronavirus pneumonia at recovery stage, application and preparation method thereof |
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Application publication date: 20160106 |