CN108853607A - A kind of insulin needle surface siliconization inorganic agent - Google Patents

A kind of insulin needle surface siliconization inorganic agent Download PDF

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Publication number
CN108853607A
CN108853607A CN201811141510.5A CN201811141510A CN108853607A CN 108853607 A CN108853607 A CN 108853607A CN 201811141510 A CN201811141510 A CN 201811141510A CN 108853607 A CN108853607 A CN 108853607A
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sodium
acid
peg
inorganic agent
needle surface
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王述林
王敏
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Guangzhou Ai Chuang Medical Technology Co Ltd
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Guangzhou Ai Chuang Medical Technology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/10—Materials for lubricating medical devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2420/00—Materials or methods for coatings medical devices
    • A61L2420/06—Coatings containing a mixture of two or more compounds

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cosmetics (AREA)

Abstract

The present invention relates to equipment surfaces processing technology fields, and in particular to a kind of insulin needle surface siliconization inorganic agent.The insulin needle surface siliconization inorganic agent, in parts by weight, including organic silicone oil 5~10, diluent 75~90.

Description

A kind of insulin needle surface siliconization inorganic agent
Technical field
The present invention relates to equipment surfaces processing technology fields, and in particular to a kind of insulin needle surface siliconization inorganic agent.
Background technique
The syringe needle of injection needle, transfusion needle, blood taking needle in medical field is generally drawn by stainless steel pipe, through later It after continuous processing, is cleaned, also silicidation is carried out to syringe needle after assembling, it is smooth outer to allow syringe needle to be formed Surface reduces its frictional resistance in puncture process as far as possible.The purpose of silicidation is to form one layer on the surface of syringe needle Very thin organosilicon oil reservoir.But this organosilicon oil reservoir cannot directly adopt organic silicone oil smearing, but organic silicone oil is dissolved In a kind of volatile solvent, the weak solution of organic silicone oil is formed, when syringe needle being then immersed in one section in this solution again Between, allow syringe needle to attach one layer of solution, dry a period of time, after the volatile solvent in solution is evaporated completely, just in syringe needle table Face leaves one layer of very thin organic silicone oil, forms extremely smooth surface.The prior art in the weak solution for preparing organic silicone oil, Trifluorotrichloroethane is usually used as solvent, the popular name of trifluorotrichloroethane is freon 113, abbreviation F113.F113 makees It is for the advantages of solvent, it does not burn, does not explode, and use is fool proof：It is nontoxic, good biocompatibility；It is organosilicon The fine solvent of oil, and boiling point is appropriate, it is volatile, it will not remain on disposable medical equipment.Therefore, F113 is disposably being cured It treats and is widely applied in instrument industry.But conventional organic silicone oil is weaker to the adhesiveness of syringe needle, in puncture process It is easy to be rubbed by skin, the people being had an injection can experience pain in the same old way, therefore researching and developing one kind keeps insulin needle head surface smooth, needle It will not meet obstructions when thorn, be truly realized the problem of painless technology is urgent need to resolve.
Summary of the invention
In order to solve the above-mentioned technical problem, the first aspect of the present invention provides a kind of insulin needle surface siliconization processing Agent, the insulin needle surface siliconization inorganic agent, in parts by weight, including organic silicone oil 5~10, diluent 75~90.
As a kind of perferred technical scheme, the organic silicone oil includes dimethyl silicone polymer and functional siloxane.
As a kind of perferred technical scheme, the kinematic viscosity of the dimethyl silicone polymer is 350~1500cSt.
As a kind of perferred technical scheme, reactive methylol is contained in the functional siloxane strand.
As a kind of perferred technical scheme, primaquine group is also contained in the functional siloxane strand.
As a kind of perferred technical scheme, also contain secondary amino group in the functional siloxane strand.
As a kind of perferred technical scheme, the diluent by 80~90 parts by weight nonpolar solvent and 10~20 weights Measure the polar solvent composition of part.
As a kind of perferred technical scheme, the diluent is by the nonpolar solvent of 85 parts by weight and the pole of 15 parts by weight Property solvent composition.
As a kind of perferred technical scheme, the insulin needle surface siliconization inorganic agent further includes the table of 1~3 parts by weight Face activating agent.
The second aspect of the invention provides the application method of insulin needle surface siliconization inorganic agent as described above, packet It includes, following steps：
(1) each raw material of insulin needle surface siliconization inorganic agent is mixed to get uniform bath foam；
(2) it will be kept at least half a minute in bath foam that needle point is impregnated in (1) step, then taken out；
It (3) is 20~40 DEG C in temperature, relative humidity solidifies 12~24 hours under the conditions of being 55~70%.
Beneficial effect：Insulin needle surface siliconization inorganic agent provided by the invention to the adhesive capacity of insulin needle syringe needle very By force, it can be adhered on syringe needle strongly, syringe needle will not be rubbed when to promoting inside skin by skin, can be significant Frictional resistance when subtracting stylet, bring real painless picotement to the person of being needled.Furthermore insulin provided by the invention Wire surface silicidation agent raw material is environmentally friendly, nontoxic, safe, inorganic agent using simple to operate, cost is small to be easy to industrialize Production.
Specific embodiment
It is further clear, complete that the technical characteristic work in technical solution is provided to the present invention With reference to embodiment Description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Based on this Embodiment in invention, every other reality obtained by those of ordinary skill in the art without making creative efforts Example is applied, shall fall within the protection scope of the present invention.
Word " preferred ", " preferably ", " preferred " in the present invention etc. refer to, can provide certain in some cases The embodiment of the present invention of a little beneficial effects.However, other embodiments may also under identical circumstances or in the case of other It is preferred.In addition, not implying that other embodiments are unavailable to the statement of one or more preferred embodiments, it is not yet It is intended to exclude other embodiments except the scope of the present invention.
In order to solve the above-mentioned technical problem, the first aspect of the present invention provides a kind of insulin needle surface siliconization processing Agent, the insulin needle surface siliconization inorganic agent, in parts by weight, including organic silicone oil 5~10, diluent 75~90.
Heretofore described organic silicone oil refers to the polysiloxane of different polymerization degree chain structure, the poly organo The organic group of alkane can be methyl or other function group.
In some embodiments, the organic silicone oil includes dimethyl silicone polymer and functional siloxane；Preferably, institute The weight ratio for stating dimethyl silicone polymer and the functional siloxane is 1：2~2：1；It is further preferred that the poly- diformazan The weight ratio of radical siloxane and the functional siloxane is 2：1.2.
In some embodiments, the kinematic viscosity of the dimethyl silicone polymer is 350~1500cSt；It is further excellent Choosing, the kinematic viscosity of the dimethyl silicone polymer is 1000cSt, and can select the DOW CORNING trade mark is 360 silicone oil.
Heretofore described kinematic viscosity refers to the dynamic viscosity and the ratio between synthermal lower fluid density ρ of fluid, should Kinematic viscosity is to be tested to obtain according to method described in chemical industry standard (HG/T 2363-92).
In some embodiments, reactive methylol is contained in the functional siloxane strand；Preferably, the function Primaquine group can also be contained in siloxane molecule chain；It is furthermore preferred that also containing secondary amino group in the functional siloxane strand.
Primaquine group of the present invention refers to-NH2Group, the secondary amino group refer to-NH- group.Institute in the present invention It states reactive methylol and refers to the methylol connected with silicon atom, such as-Si-OCH3Etc. structures, can be a reactive hydroxyl Methyl is also possible to multiple reactive methylols.It is 4159 silicone oil that functional siloxane in the present invention, which can be the DOW CORNING trade mark,.
In some embodiments, the diluent by 80~90 parts by weight nonpolar solvent and 10~20 parts by weight Polar solvent composition；Preferably, the diluent is made of the nonpolar solvent of 85 parts by weight and the polar solvent of 15 parts by weight.
Nonpolar solvent in the present invention refers to the low a kind of solvent of dielectric constant, can be molten for aliphatic nonpolarity Agent, or aromatic nonpolar solvent, such as fat oil, atoleine, ethyl acetate, petroleum ether, ether etc..This hair Polar solvent in bright refers to the higher a kind of solvent of dielectric constant, can be propyl alcohol, isopropanol, ethyl alcohol, hexafluoroisopropanol etc..
In some embodiments, the insulin needle surface siliconization inorganic agent further includes the surface-active of 1~3 parts by weight Agent.
In the present invention any restriction is not carried out to the surfactant, not influenced at insulin needle surface siliconization It can be almond amido propyl amine oxide, almond amido propyl betaine, aminopropyl laurel under the premise of managing agent correlated performance Base glutamine, C12-15Alkylsurfuric acid ammonium, C12-16Alkylsurfuric acid ammonium, ammonium cocoyl ammonium sulfate, cocoyl ammonium sulfate, coconut palm Oleoylsarcosine ammonium, C12-15Alkyl sulfonic acid ammonium, C9-10Perfluoro alkyl sulfonic acid ammonium, nonyl sulfosuccinic acid ammonium, detergent alkylate Ichthyodin, isostearic acid ammonium, -6 carboxylic acid ammonium of laureth 9, -8 carboxylate of ammonium laureth 9, poly- second two 12 ether ammonium sulfate of alcohol list, -5 ammonium sulfate of laureth 9, -7 ammonium sulfate of laureth 9, polyethyleneglycol - 9 ammonium sulfate of ten diether, -12 ammonium sulfate of laureth, Hamposyl L ammonium, Texapon Special, lauryl sulfosuccinic Sour ammonium, myristyl alcohol polyethers ammonium sulfate, myristyl sulfate ester, -4 sulfuric ester of ammonium nonoxinol, -30 sulfuric acid of ammonium nonoxinol Ammonium, ammonium oleate, palm kernel ammonium sulfate, ammonium stearate, sorbic acid ammonium, AMPD- isostearoyl hydrolytic collagen, the hydrolysis of AMPD- rosin Collagen, AMP- isostearoyl hydrolytic collagen, AMP- isostearoyl hydrolysis of keratin, AMP- isostearoyl hydrolytic soya bean protein, AMP- isostearoyl hydrolyzed wheat protein, almond amido propyl betaine, arachidic acid, arginine hexyl decylphosphonic acid ester, avocado Amido propyl betaine, -8 ester of avocado oil glycerin polyether, Babassu acid, Babassu amido propyl amine oxide, Babassu amide Propyl betaine, beeswax acid, behenyl amido propyl betaine, behenamide oxide, docosyl alcohol polyethers -25, docosyl alcohol are poly- Ether-docosyl dimethyl silicone polymer polyglycereol -3, -5 carboxylic acid of butylphenol polyethers, -19 carboxylic acid of butylphenol polyethers, fourth Base dimethyl hydroxypropyl butyl glucoside chloride, Butyldimethyl hydroxypropyl lauryl glucoside chloride, butyl glucoside, Butyl glucoside caprate, butyl glucoside hydroxypropyl-trimethyl ammonium chloride, butyl octanoic acid, C18-36Acid, C20-40Acid, C30-50Acid, C16-22Sour amide MEA, calcium dodecyl benzene sulfonate, lauroyl calcium taurinate, C9-16Alkane/cycloalkane, C10-14Alkyl benzene sulphonate, C12-14Alkyl diamino ethyl glycines hydrochloride, C9-15Alkylphosphonic, candida albicans Candida/glucose/methyl vegetable seed Fry dried food ingredients ferment, canolamidopropyl glycine betaine, capric acid, caproic acid, caproyl ethyl cyclophosphadenosine glycoside, decoyl/caprinoyl aminopropyl It is glycine betaine, -4 carboxylic acid of octanol polyethers, -6 carboxylic acid of octanol polyethers, -9 carboxylic acid of octanol polyethers, octanoic acid, caprylyl collagen amino acid, pungent Acylglycine, caprylyl hydrolytic collagen, caprylyl hydrolysis of keratin, caprylyl Keratin amino acids class, caprylyl silk ammonia It is base acids, octyl/Plantacare 818, octyl/decyl wheat bran/straw glycoside, caprylyl glucoside, laurylpropylene glycol ether, pungent Acyl pyrroline alkanone, meat (poison) alkali, ceteareth -20, ceteareth -23, ceteareth -24, Ceteareth -25, ceteareth -27, ceteareth -28, ceteareth -29, spermaceti Stereth -30, ceteareth -33, ceteareth -34, ceteareth -40, cetearyl alcohol Alcohol polyethers -50, ceteareth -55, ceteareth -60, ceteareth -80, cetostearyl alcohol are poly- Ether -100, -25 carboxylic acid of ceteareth, -2 phosphate of ceteareth, -4 phosphate of ceteareth, whale - 5 phosphate of wax stereth, -10 phosphate of ceteareth, ceteth -20, ceteth -23, spermaceti Alcohol polyethers -24, ceteth -25, ceteth -30, ceteth -40, ceteth -45, ceteth - 150, -8 phosphate of ceteth, -10 phosphate of ceteth, -20 phosphate of ceteth, spermaceti oleth - 22, spermaceti oleth -24, spermaceti oleth -25, spermaceti oleth -30, cetyl betaine, chrysanthemum extract, C12-14Hydroxyalkyl ethoxy Beta-alanine, C12-14Hydroxyalkyl ethoxy sarcosine, cocoamidoethyl betaine, cocounut oil acyl Amidopropyl amine oxide, Cocamidopropyl coconut oleoyl amine MEA chloride, cocoamidopropyl, cocounut oil acyl ammonia Base hydroxysultaine, cocamidopropyl propyl amide hydroxyl sulfo betaine, cocoamido propionic acid, carboxyl lauric alcohol are poly- - 4 glucoside of ether, cocounut oil both sexes dipropionic acid, cocoamido both sexes propionate, coco betaine, cocodimonium hydroxyl Propyl hydrolysed rice albumen, cocodimonium hydroxypropyl base hydrolytic soya bean protein, cocoyl dimethyl Hydroxypropyl Hydrolyzed Wheat Albumen, cocoyl glucoside, cocoyl glucoside hydroxypropyl-trimethyl ammonium chloride, Coco-Hydroxysultaine, cocoyl Morpholine oxide, coconut acid, coconut oil glyceryl -8- ester, cocounut oil/oleamide propyl betaine, coco sultaine, coconut palm Oil/sunflower seeds aminopropyl glycine betaine, cocoyl choline Methylsulfate, coco group Hydrolyzed Collagen, coco group hydrolytic collagen Albumen, cocounut oil acyl hydrolysis of keratin, cocoyl hydrolysis avenin, cocoyl hydrolyze rice gluten, cocoyl hydrolyzed-silk, cocoyl Hydrolytic soya bean protein, cocoyl hydrolyzed wheat protein, cocoyl sarcosine, maizenic acid, cottonseed oil, -8 ester of cottonseed oil glycerin ether, C10-16Alkanol polyethers -1, C10-16Alkanol polyethers -2, C11-13Alkanol polyethers -6, C11-13Alkanol polyethers -9, C11-13Alkanol polyethers- 10、C11-15Alkanol polyethers -30, C11-15Alkanol polyethers -40, C12-13Alkanol polyethers -1, C12-13Alkanol polyethers -23, C12-14Alkanol Polyethers -5, C12-14Alkanol polyethers -9, C13-15Alkanol polyethers -21, C14-15Alkanol polyethers -8, C20-22Alkanol polyethers -30, C20-40Alkane Alcohol polyethers -40, C20-40Alkanol polyethers -95, C22-24Alkanol polyethers -33, C30-50Alkanol polyethers -40, C9-11- 6 carboxylic of alkanol polyethers Acid, C9-11- 8 carboxylic acid of alkanol polyethers, C12-15- 7 carboxylic acid of alkanol polyethers, C12-13- 5 carboxylic acid of alkanol polyethers, C12-13- 7 carboxylic of alkanol polyethers Acid, C12-13- 8 carboxylic acid of alkanol polyethers, C12-13- 12 carboxylic acid of alkanol polyethers, C12-15- 7 carboxylic acid of alkanol polyethers, C12-15Alkanol polyethers -8 Carboxylic acid, C12-15- 12 carboxylic acid of alkanol polyethers, C14-15- 8 carboxylic acid of alkanol polyethers, C6-10- 4 phosphate of alkanol polyethers, C12-13Alkanol is poly- - 2 phosphate of ether, C12-13- 10 phosphate of alkanol polyethers, C12-15- 6 phosphate of alkanol polyethers, C12-15- 8 phosphate of alkanol polyethers, C12-15- 10 phosphate of alkanol polyethers, C12-16- 6 phosphate of alkanol polyethers, C4-18The thio Hydroxyproyl Trimethyl chlorine of perfluor alkyl ethide Change ammonium, great Hua cocoa fat amido propyl betaine, DEA-C12-13Alkyl sulfate, DEA-C12-15Alkyl sulfate, DEA- whale - 2 phosphate of wax stereth, DEA- cetyl sulfate, DEA- cocounut oil both sexes dipropionate, DEA-C12-13Alkanol is poly- - 3 sulfate of ether, DEA- cyclo-dodecyl acrylate, DEA- dodecyl benzene sulfonate, DEA- lauryl sulfate, DEA- Lauryl sulfate, DEA- linoleate, DEA- methyl myristate, DEA- myristyl alcohol polyethers sulfate, DEA- nutmeg Hydrochlorate, DEA- myristyl sulfate, -5 phosphate of DEA- oleth, DEA- oleth -20PhosDEAPG- oleate, - 7 carboxylic acid of decyl alcohol polyethers, -7 glucoside of decyl alcohol polyethers, -9 phosphate of decyl alcohol polyethers, decyl amine oxide, decyl betaine, decyl Portugal Glucosides, decyl alkyl polyoxyethylene ether -30, decyl alkyl amine oxide, diammonium lauramide-MEA sulfosuccinic acid Salt, diammonium lauryl sulfosuccinates, diammonium oleoyl amino PEG-2 sulfosuccinate, dibutoxy methane, two-C12-15 - 2 phosphate of alkanol polyethers, two-C12-15- 4 phosphate of alkanol polyethers, two-C12-15- 6 phosphate of alkanol polyethers, two-C12-15Alkanol - 8 phosphate of polyethers, two-C12-15- 10 phosphate of alkanol polyethers, dilauryl butane propane tetracarboxylic acid tetra-ethyl ester, laureth Sulfuric ester diethylamine salt, sulfosuccinic acid ethylhexyl sodium, dihydroxy ethyl C8-10Alkoxy propyl amine oxide, dihydroxy second Base C9-11Alkoxy propyl amine oxide, dihydroxy ethyl C12-15Alkoxypropan amine oxide, dihydroxy ethyl cocoamine oxide, Dihydroxy ethyl lauryl amine oxide, dihydroxy ethyl tristearin amine oxide, dihydroxy ethyl tallow amine oxide, dimethyl silicone polymer PEG-7 phosphate, dimethyl silicone polymer PEG-10 phosphate, dimethyl silicone polymer PEG/PPG-7/4 phosphate, poly- diformazan Radical siloxane PEG/PPG-12/ phosphate, -3 cross-linked polymer of dimethyl silicone polymer/polyglycereol, dimethyl silicone polymer third Base PG- glycine betaine, dimethyl phosphate, dioleoyl amino-ethyl hydroxyethyl methyl ammonium sulfate, DIPA- hydrogenated coco acid esters, DIPA- Wool acid esters, myristic acid dipotassium, caprylyl capryl glutamic acid dipotassium, lauryl sulfosuccinic acid dipotassium, endecatylene acyl Glutamic acid dipotassium, Babassu amide MEA- disodium sulfosuccinate, caprinoyl both sexes base diethyl acid disodium, caprinoyl both sexes base dipropionic acid Disodium, decoyl both sexes base diethyl acid disodium, decoyl both sexes base disodium beclomethasone, glutamic acid Fructus Forsythiae ester disodium, cetostearyl alcohol sulphur Base succinate disodium, cetyl phenyl ether disulfonate, disodium sulfosuccinate, cocoamido MEA- sulfosuccinic Acid disodium, cocoamido MIPAPEG-4 disodium sulfosuccinate, cocoamido MIPA- disodium sulfosuccinate, cocounut oil acyl Amino PEG-3 disodium sulfosuccinate, -3 disodium sulfosuccinate of coceth, cocounut oil acyl both sexes base carboxy ethyl hydroxyl third Base sodium sulfonate, cocounut oil acyl both sexes base diethyl acid disodium, cocounut oil both sexes disodium beclomethasone, cocoyl disodium sulfosuccinate, cocounut oil - 10 disodium sulfosuccinate of base butyl glucitol polyethers, cocoyl glutamate disodium, C12-14- 1 sulfosuccinic acid two of alkanol polyethers Sodium, C12-14- 2 disodium sulfosuccinate of alkanol polyethers, C12-15Alkanol polyethers disodium sulfosuccinate, C12-14Secondary chain-alkanol is poly- - 3 disodium sulfosuccinate of ether, C12-14Secondary chain--5 disodium sulfosuccinate of alkanol polyethers, C12-14Secondary chain--7 sulfo group of alkanol polyethers Disodium succinate, C12-14Secondary chain--9 disodium sulfosuccinate of alkanol polyethers, C12-14Secondary chain--12 sulfosuccinic acid of alkanol polyethers Disodium, decyl -5- disodium sulfosuccinate, decyl -6- disodium sulfosuccinate, decyl phenyl ether disulfonate, vulcanization amber Double hard bis- disodium sulfates of amide PEG-15 of amber acyl endecatylene acid disodium, ethylene glycol, hydrogenated cotton seeds glyceride sulfosuccinic acid two Sodium, hydrogenated tallow disodium glutamate, hydroxydecyl D-sorbite disodium citrate, isodecyl disodium sulfosuccinate, different tristearin Amide MEA- disodium sulfosuccinate, disodium sulfosuccinate, -5 disodium sulfosuccinate of lanolin alcohol polyethers, lauramide MEA- disodium sulfosuccinate, lauramide MIPA glycerol disodium sulfosuccinate, lauramide PEG-2 sulfosuccinic acid two Sodium, lauramide PEG-5 disodium sulfosuccinate, -5 carboxyl both sexes diethyl acid disodium of laureth 9, polyethylene glycol - 7 disodium citrate of single ten diether, laureth 9 disodium sulfosuccinate, -6 sulfo group amber of laureth 9 Amber acid disodium, -9 disodium sulfosuccinate of laureth 9, -12 disodium sulfosuccinate of laureth 9, Lauryl dihydroxypropyl disodium sulfonate, lauryl dihydroxypropionic acid disodium, lauryl disodium beclomethasone, lauryl dipropionic acid two Sodium, lauryl disodium beclomethasone, lauryl disodium beclomethasone, lauryl both sexes diethyl acid disodium, lauryl both sexes dipropionic acid two Sodium, N- lauroyl aspartic acid disodium, lauroyl glutamate disodium, lauryl phenyl ether disulfonate, lauryl sulphur Base disodium succinate, myristamide MEA- disodium sulfosuccinate, -10 disodium sulfosuccinate of nonoxinol, oleoyl amino MEA- disodium sulfosuccinate, oleoyl amido MIPA- disodium sulfosuccinate, oleoyl amido PEG-2 disodium sulfosuccinate, oil Acyl group both sexes disodium beclomethasone, oleyl alcohol ether -3- disodium sulfosuccinate, oil base disodium hydrogen phosphate, oil base disodium sulfosuccinate, palm fibre Palmitic acid amide groups PEG-2 disodium sulfosuccinate, PEG-4 cocamidopropyl MIPA- disodium sulfosuccinate, PEG-12 poly dimethyl Siloxanes disodium sulfosuccinate, PEG-8 palm glycerides disodium sulfosuccinate, PPG-2- isodecyl -7- carboxyl both sexes two Acetic acid disodium, castor oil acylamino- disodium MEA- disodium sulfosuccinate, Sitostereth-14 disodium sulfosuccinate, soybean Oleoyl both sexes base diethyl acid disodium, stearmide MEA- disodium sulfosuccinate, stearic iminodipropionate, stearoyl two Property base diethyl acid disodium, stearoyl-glutamic acid disodium, stearyl sulfosuccinamic acid disodium, stearic acid sulfosuccinic acid two Sodium, 2- disodium sulfosuccinate, 2- sulfo group palm acid disodium, Carvedilol oleamide MEA disodium-disodium sulfosuccinate, The double propionic acid disodiums of TallowamidoMEA- disodium sulfosuccinate, tallow acyl both sexes base diethyl acid disodium, tallow imino group, ox Rouge sulfosuccinamic acid disodium, tridecyl disodium sulfosuccinate, undecyl acylamino- MEA- disodium sulfosuccinate, Endecatylene acylamino- PEG-2 disodium sulfosuccinate, endecatylene acyl disodium glutamate, MEA- disodium sulfosuccinate, wheat Embryo oleamide PEG-2 disodium sulfosuccinate, wheat germ oleoyl both sexes base diethyl acid disodium, two TEA- cocounut oil diacetates, two TEA- oleoyl amino PEG-2 sulfo group, two TEA palm aspartic acids, double 13 ester sodium sulfonates, dodecyl benzene sulfonic acid, erucic acid acyl Amine propyl betaine, ethyl hexanol polyethers -3- carboxylic acid, ethyl ester, PEG-15 coco amine sulfate, glycerol octyl ether, hexyldecanoic acid, hydrogen Change coconut acid, hydrogenated lanolin alcohol polyethers -25, hydrogenation Pacific herring acid, hydrogenated palm acid, hydrogenated palm kernel amine oxide, hydrogenated tallow it is sour, Hydrogenated tallow amine oxide, hydrogenated tallow glycine betaine, h-tallow rouge -25, h-tallow acyl glutamic acid, hydrolysis Candida Extract, hydroxyl cetyl ether -60, ethoxy acetyl Mo PG- dimethyl silicone polymer, ethoxy butylamine polyethyleneglycol 12 Ether sulfate, hydroxyethyl-carboxymethyl cocamidopropyl propyl amide amine, hydroxyethyl hydroxypropyl base C12-15Alkoxy propyl amine oxide, hydroxylauric Base/hydroxyl myristyl betaine, hydroxystearic acid, HOSu NHS C10-40Isoalkyl acid, HOSu NHS C21-22 Isoalkyl acid esters, hydroxyl sulfo betaine, IPDI/PEG-15 soybean amine oxide copolymer, IPDI/ phosphate, different polyglycereol- 3 dimethyl silicone polymers, -3 dimethiconol of different polyglycereol, isopropanolamine wool acid esters, isopropylamine detergent alkylate Sulfonate, isostearoyl amine propyl amine oxide, isostearoyl amine propyl betaine, isostearoyl amine propylmorpholin oxide, Isosteareth -8, isosteareth -16, isosteareth -22, isosteareth -25, isosteareth - 50, Iso stearic acid, isostearoyl hydrolytic collagen, SIMMONDSIA CHINENSIS SEED OIL PEG-150 ester, jojoba waxes PEG-80 ester, jojoba waxes PEG- 120 esters, lanolin alcohol polyethers -20, lanolin alcohol polyethers -25, lanolin alcohol polyethers -40, lanolin alcohol polyethers -50, lanolin Alcohol polyethers -60, lanolin alcohol polyethers-lanoceric acid, dodecanamide propyl amine oxide, lauroylamidopropyl betaine, laurel Amido propyl hydroxyl sulfo betaine, lauryl amine oxide, lauryl amino propionic acid, lauryl dimethyl hydroxypropyl decyl Portugal Glucosides chloride, lauryl dimethyl hydroxypropyl lauryl lauryl alcohol -4, ethoxylated dodecyl alcohol 13, polyethyleneglycol ten Diether-16, laureth 9-20, laureth 9-21, laureth 9-23, polyethylene glycol Single ten diether-25, laureth 9-30, laureth 9-38 ,-6 carboxylic of carboxylic acid laureth 9 - 11 poly- second two of carboxylic acid of -10 carboxylic acid laureth 9 of acid polyethylene glycol list -8 carboxylic acid laureth 9 of ten diether - 14 carboxylic acid polyethyleneglycol 12 of -13 carboxylic acid laureth 9 of alcohol list -12 carboxylic acid laureth 9 of ten diether - 17 carboxylic acid of ether, -6 citrate of laureth 9, -7 citrate of laureth 9, polyethyleneglycol ten - 1 phosphate of diether, -2 phosphate of laureth 9, -3 phosphate of laureth 9, polyethyleneglycol 12 - 4 phosphate of ether, -7 phosphate of laureth 9, -8 phosphate of laureth 9, polyethyleneglycol 12 - 7 tartrate of ether, lauric acid, laurel imino-diacetic lauroyl dimethyl siloxane/polyglycereol-lauryl dimethyl silicon oxygen Alkane/polyglycereol-lauryl dimethicone/lauroyl dimethyl siloxane/lauroyl dimethyl siloxane/lauroyl Base sarcosine, lauroyl sarcosine, lauroyl silk amino acid, lauroyl glycine betaine, lauryl dimethicone/poly- - 3 cross-linked polymer of glycerol, cocoyl glucoside lauryl dimethyl hydroxypropyl ammonium chloride, laurel ethyl glycol hydroxypropyl ether, the moon Osmanthus base hydroxyl sulfo betaine, lauryl maleic amide, lauryl methyl glucamide, lauryl/myristyl ethylene glycol hydroxyl Propyl ether, lauryl/myristyl wheat bran/straw glucosides, -3 poly dimethyl siloxy ethyl of lauryl polyglyceryl are poly- Dimethyl siloxane, Lauryl pyrolidone, lauryl betaine, linoleic acid, linolenic acid, linseed acid, lysine coconut oil Ester ,-8 ester of Queensland nut seed oil glyceride, magnesium dodecyl benzene sulfonate, magnesium dodecyl benzene sulfonate, laureth 9- 11 magnesium carboxylates, laureth 9 magnesium sulfate, -5 magnesium sulfate of laureth 9, -8 sulphur of laureth 9 Sour magnesium, -16 magnesium sulfate of laureth 9, -3 sulfosuccinic acid magnesium of laureth 9, lauryl hydroxypropyl sulphur Sour magnesium, Stepanol MG, lauryl magnesium sulfate, methyl cocoyl base magnesium taurate, lauryl polyoxyethylene wax, sulfuric acid laurel Base magnesium, TEA- cocounut oil magnesium sulfate, Ma Nikua root clay, MEA- cocounut oil acid esters, -6 carboxylate of MEA- laureth, MEA- laurel Alcohol sulfuric ester, MEA- lauryl sulfate ester, -7 carboxylate of MEA-PPG-6 laureth, MEA-PPG-8- stereth -7 Carboxylate, MEA- undecylenate, Metro bed ripples 108, Metro bed ripples 174, Metro bed ripples 178, Metro bed ripples 254, Metro Bed ripples 255, Metro bed ripples 258, Metro bed ripples 314, methoxyl group PEG-450 amino glutaryl succinimide, methoxyl group PEG-450 acylamino- hydroxysuccinimidyl acylimino Succinamate, methoxyl group PEG-450 maleimide, methyl morpholine oxygen Compound, milk amido propyl amine oxide, milk amido propyl betaine, ermine oil amide propylamine oxide, ermine oil amido propyl Glycine betaine, MIPA- dodecyl benzene sulfonate, MIPA- dodecyl benzene sulfonate, MIPA- lauryl sulfate, the MIPA- month Osmanthus base sulfate, mixing isopropanolamine wool hydrochlorate, mixing isopropanolamine lauryl sulfate, mixing isopropanolamine nutmeg Hydrochlorate, morpholine oleate, morpholine stearate, -3 carboxylic acid of myristyl alcohol polyethers, myristamide propyl-dimethyl amine phosphate, Myristamide hydroxysultaine, myristamide propyl pg dimonium chloride phosphate, nutmeg amine oxygen Compound, nutmeg amine propionate, myristate, myristoyl ethyl trimethyl ammonium methylsulfate, myristoyl paddy Propylhomoserin, myristoyl hydrolytic collagen, myristoyl-N-methylaminoacetic acid salt, myristyl betaine, myristyl/cetyl oxidation Amine, myristyl dimethyl hydroxyl propyl cocoyl glucoside chloride, myristyl glucoside, myristyl phosphate, nonyl Menthylphenoxypolyethoxy ethanol -20, nonoxinol -23, nonoxinol -25, nonoxinol -30, nonoxinol -35, nonoxinol -40, nonylbenzene alcohol Ether -44, nonoxinol -50, nonoxinol -100, nonoxinol -120, -5 carboxylic acid of nonoxinol, -8 carboxylic acid of nonoxinol, nonyl - 10 carboxylic acid of menthylphenoxypolyethoxy ethanol, -3 phosphate of nonoxinol, -4 phosphate of nonoxinol, -6 phosphate of nonoxinol, Nonoxynol-9 phosphorus Hydrochlorate, -10 phosphate of nonoxinol, nonyl nonoxinol 30, nonyl nonoxinol 49, nonyl nonoxinol 10 0, nonyl nonylbenzene Alcohol ether 150, the phosphate of nonyl nonoxinol 7, -8 phosphate of nonyl nonoxinol, nonyl Nonoxynol-9 phosphate, nonyl Nonoxinol 10 phosphate, 11 phosphate of nonyl nonoxinol, nonyl nonoxinol 15 phosphate, 24 phosphoric acid of nonyl nonoxinol Salt, oat oil amido propyl betaine, Octoxinol 16, Octoxinol 25, Octoxinol 30, Octoxinol 33, Octoxinol 40, Octoxinol 70,20 carboxylic acid of Octoxinol, octyl dodecanol polyethers -20, octyl dodecanol polyethers -25, octyl dodecanol are poly- Ether -30, oleamide propyl oxide, oleamide propyl betaine, oleamide propyl hydroxy sulphur, oleyl amine oxide, oleic acid, oleoyl Hydrolyzed Collagen, oleoyl sarcosine, oleth -20, oleth -23, oleth -24, oleth -25, oleyl alcohol Polyethers -30, oleth -35, oleth -40, oleth -44, oleth -50, -3 carboxylic acid of oleth, oleyl alcohol are poly- - 6 carboxylic acid of ether, -10 carboxylic acid of oleth, oil-based betaine, oleamide propyl oxide, olivamidopropyl propyl betaine, olive Olive acid, olive oil hydrolysis wheat gluten, tuber of dwarf lilyturf extract, stearic acid ozonisation oleth -10, ozonisation PEG-10 oleic acid Ester, ozonisation PEG-14 oleate, ozonisation Tween 80, palmitinic acid, palmitamide propyl betaine, 2 phosphate of palmityl, palm fibre Palmitic acid amido propyl amine oxide, palmitamide propyl betaine, palm amine oxide, palmitinic acid, palmityl collagen amino acid, palm fibre Palmitic acid acyl glycine, palmityl Hydrolyzed Collagen, the lactoprotein of palmityl hydrolysis, palmityl hydrolyzed wheat protein, palmityl Keratin amino acids, palmitoyl oligopeptide, palmityl silk amino acid, palm kernel acid, palmitamide propyl betaine, persic oil are sweet - 8 ester of grease, arachidic acid, PEG-10 castor oil, PEG-40 castor oil, PEG-44 castor oil, PEG-54 castor oil, PEG-55 castor Sesame oil, PEG-60 castor oil, PEG-80 castor oil, PEG-100 castor oil, PEG-200 castor oil, PEG-11 coconut oleoyl amine, PEG-6 coconut oleoyl amine PhoPEG-12 coco amine, PEG-12 coco amine, bis- behenate of PEG-150, bis- isostearic acid of PEG-90 Ester, PEG-75 dilaurate, PEG-150 dilaurate, PEG-75 dioleate, PEG-150 dioleate, PEG-75 bis- Stearate, PEG-120 distearate, PEG-150 distearate, PEG-175 distearate, PEG-190 distearyl Acid esters, PEG-250 distearate, PEG-30 cocounut oil acid glyceride, PEG-40 cocounut oil acid glyceride, PEG-78 cocounut oil acid glycerol Ester, PEG-80 cocounut oil acid glyceride, PEG-30 iso stearic acid of glycerine ester, PEG-40 glyceryl isostearate, PEG-50 glycerol are different Stearate, PEG-60 iso stearic acid of glycerine ester, PEG-30 glyceryl isostearate, PEG-23 glyceryl laurate, PEG-30 glyceryl laurate, PEG-25 glyceryl oleate, PEG-30 glyceryl oleate, PEG-30 glyceryl behenic acid Ester, PEG-25 glyceryl monostearate, 40 tristerins, PEG-120 tristerin, PEG-200 glycerol stearate Ester, PEG-28 glycerin fatty acid ester, PEG-80 glycerin fatty acid ester, PEG-82 glycerin fatty acid ester, PEG-130 glycerol Base aliphatic ester, PEG-200 glycerin fatty acid ester, PEG- castor oil, PEG-50 rilanit special, PEG-54 hydrogenated castor Oil, PEG-55 rilanit special, PEG-60 rilanit special, PEG-80 rilanit special, PEG-100 rilanit special, PEG- 200 rilanit specials, PEG-30 hydrogenated lanolin, PEG-70 hydrogenated lanolin, PEG-50 hydrogenated palm amide, PEG-2 are different hard Resin acid ester, PEG-3 isostearate, PEG-4 isostearate, PEG-6 isostearate, PEG-8 isostearate, PEG-10 Isostearate, PEG-12 isostearate, PEG-20 isostearate, PEG-30 isostearate, PEG-40 isostearic acid Ester, PEG-26 Jojoba acid, PEG-40 Jojoba acid, PEG-25 Jojoba alcohol, PEG-26 Jojoba alcohol, PEG-40 Jojoba Alcohol, PEG-35 lanolin, PEG-40 lanolin, PEG-50 lanolin, PEG-55 lanolin, PEG-60 lanolin, PEG-70 sheep Hair rouge, PEG-75 lanolin, PEG-85 lanolin, PEG-100 lanolin, PEG-150 lanolin, PEG-75 lanolin oil, PEG-2 Laura amine, PEG-3 Laura amine oxide, PEG-20 laurate, PEG-32 laurate, PEG-, PEG-150 laurel Acid esters, PEG-70 mango glyceride, PEG-20 mannosan laurate, PEG-8 methyl ether dimethicone, PEG- 120 methyl glucose dioleates, two acid esters of PEG-80 methyl, PEG-120 methyl glucoside trioleate, PEG-4 are brown Coal acid esters, PEG-30 oleyl amine, PEG-20 oleate, PEG-23 oleate, PEG-32 oleate, PEG-36 oleate, PEG-75 Oleate, PEG-150 oleate, PEG-20 palmitate, -2 tristearate of PEG-150 polyglyceryl, PEG/PPG-28/21 Acetic acid dimethyl silicone polymer, PEG/PPG-24/18 butyl ether dimethyl silicone polymer, PEG/PPG-3/17 copolymer, PEG/ PPG-5/35 copolymer, PEG/PPG-8/55 copolymer, PEG/PPG-10/65 copolymer, PEG/PPG-12/35 copolymer, PEG/PPG-16/17 copolymer, PEG/PPG-20/9 copolymer, PEG/PPG-20/20 copolymer, PEG/PPG-20/65 copolymerization Object, PEG/PPG-22/25 copolymer, PEG/PPG-28/30 copolymer, PEG/PPG-35/40 copolymer, PEG/PPG-50/40 Copolymer, PEG/PPG-150/35 copolymer, PEG/PPG-160/30 copolymer, PEG/PPG-190/60 copolymer, PEG/ PPG-300/55 copolymer, PEG/PPG-20/22 methyl ether dimethicone, PEG-26-PPG-30 phosphate, PEG/ PPG-4/2 propylheptyl ether, PEG/PPG-6/2 propylheptyl ether, PEG-7/PPG-2 propylheptyl ether, PEG/PPG-8/2 propyl Heptyl ether, PEG/PPG-10/2 propylheptyl ether, PEG/PPG-14/2 propylheptyl ether, PEG/PPG-40/2 propylheptyl ether, PEG/PPG-10/2 ricinoleate ester, PEG/PPG-32/3 ricinoleate ester, PEG-55 propylene glycol oleate, PEG-25 propylene glycol Stearate, PEG-75 propylene glycol stearate, PEG-120 propylene glycol stearate, PEG-5 brassicasterol, PEG-10 vegetable seed Sterol, PEG-40 ricinoleamide, PEG-75 missible oil glyceride, PEG-75 shore milk fatty acids glyceride, PEG-20 are dehydrated mountain Pears sugar alcohol cocounut oil acid esters, PEG-40 sorbitan isostearate, PEG-40 dehydrated sorbitol mono-fatty acid ester, PEG-75 Dehydrated sorbitol mono-fatty acid ester, PEG-10 sorbitan laurate esters, PEG-40 sorbitan laurate esters, PEG-44 sorbitan laurate, PEG-20 sorbitanoleate, PEG-80 sorbitan palmitinic acid Ester, PEG-40 sorbitan stearate, PEG-60 stearic acid sorbitan ester, PEG-160 sorbitan Three isostearates, PEG-40 sojasterol, PEG-2 stearic amide carboxylic acid, PEG-20 stearate, PEG-23 stearic acid Ester, PEG-25 stearate, PEG-30 stearate, PEG-32 stearate, PEG-35 stearate, PEG-36 stearic acid Ester, PEG-40 stearate, PEG-45 stearate, PEG-50 stearate, PEG-55 stearate, PEG-75 stearic acid Ester, PEG-90 stearate, PEG-100 stearate, PEG-120 stearate, PEG-150 stearate, PEG-45 are stearic Acid esters phosphate, PEG-20 aliphatic ester, PEG-50 tallow amide, PEG-2 tallow amine DEA, PEG-20 tallow acid, PEG-66 tri- Hydroxystearin, PEG-200 trihydroxy tristerin, PEG-60Tsubakiate glyceride, Pelardonic Acid, pentadecyl phenol polyethers -200, -6 phosphate of phenethyl, poloxamer 105, poloxamer 108, poloxamer 182, pool Luo Shamu 183, poloxamer 184, PLURONICS F87, poloxamer 217, poloxamer 234, poloxamer 235, Bo Luosha Nurse 237, poloxamer 238, poloxamer 288, poloxamer 334, poloxamer 335, Pluronic/Lutrol F 108, poloxamer 908, poloxamer 1508, polydimethylsiloxanes base PEG/PPG-24/19 butyl ether silsesquioxane, polydimethylsiloxanes base PPG-13 butyl ether silsesquioxane, -6 decylate of polyglyceryl, -10 dilaurate of polyglyceryl, -20 heptyl of polyglyceryl Caprylate, -20 hexacosane acid esters of polyglyceryl, -2 lauryl ether of polyglyceryl, -10 lauryl ether of polyglyceryl, polyglycereol - 20 caprylatecaprates, -6 caprylate of polyglycereol, Natrulon H-10 caprylate, -3 poly- diformazan of polydimethylsiloxanes base ethyl of polyglycereol Radical siloxane, four caprylate of polyglycereol -6, four glyceride of Natrulon H-10, polyquaternium -79, polyquaternium -80, polyquaternium - 81, polyquaternium -82, library horse traction lotus/leaf extract, tuckahoe extracts, fir acyl Hydrolyzed Collagen, Babassu potassium, Shan Yu Sour potassium, C9-15Alkyl phosphoric acid potassium, C11-15Alkylphosphonate, C12-13Alkyl phosphoric acid potassium, C12-14Alkyl phosphoric acid potassium, Capric acid potassium salt, decoyl Base potassium glutamate, Capric acid potassium salt hydrolysed rice albumen, potassium potassium ricinoleate, coconut oil potassium, cocoyl glutamate potassium, the sweet ammonia of cocoyl Sour potassium, cocoyl caseinhydrolysate, cocoyl Hydrolyzed Collagen, cocoyl hydrolysed corn albumen, cocoyl hydrolysed corn egg White, cocoyl hydrolysis avenin potassium, cocoyl hydrolyze potassium potassium cocounut oil acyl hydrolysed rice albumen, cocoyl hydrolysed rice albumen Potassium, cocounut oil acyl hydrolyze serine potassium, cocounut oil acyl hydrolytic soya bean protein, cocounut oil acyl hydrolyzed wheat protein, cocounut oil acyl hydrolyzed wheat egg White, cocoyl hydrolyzed yeast albumen potassium, cocoyl coconut oil potassium, cocoyl taurine potassium, Cornate potassium, ring carboxylic propyl Potassium oleate, dihydroxy ethyl cocoamine oxide phosphate potassium, dimethyl silicone polymer PEG-7 potassium phosphate, dodecyl benzene sulfonic acid Potassium, enanthic acid potassium, hydrogenated coconut acid potassium, hydrogenated palm acid potassium, h-tallow acid potassium, hydroxy stearic acid potassium, isostearic acid potassium, wool Sour potassium, potassium laurate, -3 carboxylate of laureth, -4 carboxylate of laureth, -5 carboxylate of laureth, laruyl alcohol - 6 carboxylate of polyethers, -10 carboxylic acid potassium of laureth 9, laureth 9 potassium phosphate, lauroyl collagen egg Casamino acid, lauroyl glutamate potassium, lauroyl Hydrolyzed Collagen, lauroyl hydrolysis of pea protein, lauroyl hydrolysis are big Legumin matter, lauroyl PCA lauroyl pea amino acid, potassium lauroyl sarcosine, lauroyl serine potassium, lauroyl wheat Amino acid, lauryl potassium phosphate, lauryl potassium sulfate, linoleic acid potassium, potassium metaphosphate, methyl cocoyl base taurine potassium, nutmeg Sour potassium, myristoyl glutamate potassium, myristoyl potassium cinnamate solution rouge collagen, -12 potassium phosphate of octyl phenol, potassium oleate, Oleoyl Hydrolyzed Collagen, Olivanic Acid potassium, olive oil sour water solution avenin, olive oil acid hydrolyzed wheat protein, olive oil Acyl/lauroyl wheat amino acid, olive potassium oleate, potassium palmitate, palmityl hydrolysed corn albumen, palmityl hydrolyze oat egg White, palmityl hydrolysed rice albumen, palmityl hydrolyze almond protein, palmityl hydrolyzed wheat protein, palmitinic acid sylvite, arachidic acid Potassium, rapic acid potassium, potassium ricinoleate, myristic acid potassium, potassium stearate, stearoyl hydrolytic collagen potassium, taurine potassium, tallow fatty acid potassium, Taurine potassium, taurine potassium, -3 carboxylic acid potassium of Sodium Trideceth, -4 carboxylic acid potassium of Sodium Trideceth, 13 - 7 carboxylic acid potassium of alkyl polyoxyethylene ether, -15 carboxylic acid potassium of Sodium Trideceth, -19 potassium carboxylic of Sodium Trideceth Hydrochlorate, -6 potassium phosphate of Sodium Trideceth, -7 potassium phosphate of Sodium Trideceth, Tsubakiate potassium, 11 Carbon enoic acid potassium, endecatylene acyl Hydrolyzed Collagen, undecylenoyl hydrolysed rice albumen, PPG-30- butyl -30, PPG- 36- butyl -36, PPG-38- butyl -37, -4 phosphoric acid of PPG-30- octyl, PPG-10 cetyl ether phosphate, PPG-2C9-11 Alkanol polyethers -8, PPG-1- decyl alcohol polyethers -5, -2 carboxylic acid of PPG-3- decyl alcohol polyethers, PPG-30 ethylhexyl -4- phosphate, PPG- 20- glyceryl ether -30, PPG-2 ethoxy cocoa/isostearoyl amine, PPG-2- isodecyl ester -8, PPG-2- isodecyl ether -10, PPG- 2- isodecyl ester -18, PPG-2- isodecyl ether -25, PPG-4- isodecyl ether -10- oxypropyl trimethyl ammonium hydrolytic collagen, quaternary ammonium salt -24, season Ammonium salt -52, quaternary ammonium salt -87, rapic acid, rice bran acid, -8 ester of rice bran oil glycerin ether, castor oil amido propyl betaine, castor-oil plant Oleic acid, ricinoleic acid -40, safflower acid, Honolulu soapberry fruit extract, crystal soda grass roots powder, saponins, soap-K, soap-Na/ K, soap base, soap base-K, -8 ester of sesame oil glycerin ether, sesame amido propyl amine oxide, sesame amido propyl betaine, Butyrospermum Rouge amido propyl betaine, -8 ester of shea butter glycerin ether, Morocco's nut acyl both sexes guanidine-acetic acid sodium salt, wooden Shandong star fruit palm fibre oleic acid Sodium salt, avocado acid sodium-salt, babassu oil acyl group both sexes guanidine-acetic acid sodium salt, babassu oil acid sodium-salt, Babassu sodium sulfate salt, behenyl Acid sodium-salt, Docusate Sodium salt, dihydroxy glycine ethyl ester cocoa-portugal glycoside cross-linked polymer, the sweet ammonia of dihydroxy ethyl Sour sodium lauryl glucoside cross-linked polymer, alkyl dimethyl ammonium chloride sodium phosphate, -12 sodium sulphate of butylbenzene alcohol ether, butyl glucoside Hydroxypropyl phosphate sodium, C13-17Sodium alkyl sulfonate, C14-18Sodium alkyl sulfonate, C12-15Alkylsurfuric acid sodium salt, C10-16Sodium alkyl sulfate Salt, C11-15Sodium alkyl sulfate, C12-13Sodium alkyl sulfate, C12-15Sodium alkyl sulfate, C12-18Sodium alkyl sulfate, C16-20Alkylsurfuric acid Sodium, C9-22Alkyl sodium disulfonate, C14-17Alkyl sodium disulfonate, sodium caprate, caprinoyl both sexes guanidine-acetic acid salt, caprinoyl both sexes base hydroxypropyl Sodium sulfonate, hexyl both sexes propionate, hexanoyl N-methyltaurine sodium, Sodium Caprylate, -2 carboxylic acid sodium of octanol polyethers, -9 carboxylic acid of octanol polyethers Sodium, decoyl both sexes guanidine-acetic acid sodium, decoyl both sexes base hydroxypropyl azochlorosulfonate acid sodium, caprinoyl sodium propionate, caprylyl sodium glutamate, capryl water Solve wheat gluten sodium, octanoic acid PG- sodium sulfonate, Sodium Caprylate, -13 carboxylic acid sodium of ceteareth, cetostearyl alcohol sodium sulphate, whale - 13 carboxylic acid sodium of ceryl alcohol polyethers, sodium hexadecyl sulfate, bis- cocoyl sodium phosphate of Cocamidopropyl PG-, cocoyl third Sour sodium, cocoyl sodium propionate, -30 sodium sulphate of coceth, -30 sodium sulphate of coceth, cocoamphoacetate Sodium, cocounut oil ethyl acetoacetic acid sodium, sodium cocoamphoacetate, cocounut oil acyl both sexes base hydroxypropyl azochlorosulfonate acid sodium, cocoyl both sexes sodium acetate, Sodium coconut, coconut/Babassu/An Dila wood sodium sulphate, coconut/Babassu sodium sulphate, cocoyl glucoside Hydroxypropyl phosphate sodium, Cocoyl glucoside hydroxypropyl azochlorosulfonate acid sodium, cocoyl glucoside sodium tartrate, sodium cocoglyceryl base ether sulfonic acid sodium, cocounut oil/hydrogenation ox Rouge sodium sulphate, cocounut oil iminodiacetic acid sodium, sodium cocoglyceryl diester sodium sulphate, sodium cocoglyceryl diester sodium sulfonate, cocounut oil PG- diformazan Ammonium chloride sodium phosphate, cocoyl sodium sulfosuccinate, cocoyl sulfoacetic acid sodium, cocoyl Sodium L-alaninate, cocoyl amino Sour sodium, cocoyl collagen amino acid sodium, sodium cocoyl glutamate, sodium cocoyl glutamate, cocoyl Sodium Glycinate, cocoyl/ Hydrogenated tallow sodium glutamate, cocoyl hydrolytic collagen sodium, cocoyl hydrolyze sodium keratin, cocoyl hydrolysed rice albumen sodium, coconut palm Oil base hydrolyzed-silk sodium, cocoyl hydrolytic soya bean protein sodium, cocoyl hydrolyze dessert almond protein, cocoyl hydrolyzed wheat protein matter Sodium, cocoyl hydrolyzed wheat protein matter sodium glutamate, cocoyl isethionate, sodium cocoyl methyl alanine sodium, ammonia Base acid, cocoyl/palmityl/sunflower sodium glutamate, cocoyl Sodium proline, cocoylsarcosine, cocoyl taurine Sodium, cocoyl Sodium L-threonine, cocoyl wheat amino acid sodium, C12-14Alkene sulfonic acid sodium, C14-16Alkene sulfonic acid sodium, C14-18Alkene Sulfonate, C16-18Alkene sulfonic acid sodium, corn oleoyl both sexes base sodium propionate, cotton seeds acyl both sexes guanidine-acetic acid sodium, C13-15Alkanol is poly- - 8 butyl phosphoric acid sodium of ether, C9-11- 6 carboxylic acid sodium of alkanol polyethers, C11-15- 7 carboxylic acid sodium of alkanol polyethers, C12-13- 5 carboxylic acid of alkanol polyethers Sodium, C12-13- 8 carboxylic acid sodium of alkanol polyethers, C12-13- 12 carboxylic acid sodium of alkanol polyethers, C12-15- 6 carboxylic acid sodium of alkanol polyethers, C12-15Alkanol - 7 carboxylic acid sodium of polyethers, C12-15- 8 carboxylic acid sodium of alkanol polyethers, C14-15- 8 carboxylate of alkanol polyethers sodium, C12-14Secondary chain-alkanol polyethers -8 Carboxylic acid sodium, C14-15Alkanol polyethers-PG sodium sulfonate, C12-13- 2 sodium phosphate of alkanol polyethers, C13-15- 8 sodium phosphate of alkanol polyethers, C9-15 - 3 sodium sulphate of alkanol polyethers, C10-15Alkanol polyethers sodium sulphate, C10-16- 2 sodium sulphate of alkanol polyethers, C12-13Alkanol polyethers sodium sulphate, C12-15Alkanol polyethers sodium sulphate, C12-15- 3 sodium sulphate of alkanol polyethers, C13-15- 3 sodium sulphate of alkanol polyethers, C12-14Secondary tridecyl Sodium sulphate, C12-15- 3 sodium sulfonate of alkanol polyethers, C12-15- 7 sodium sulfonate of alkanol polyethers, C12-15- 15 sodium sulfonate of alkanol polyethers, decyl alcohol - 2 carboxylic acid sodium of polyethers, lauryl sodium sulfate, decylbenzene sulfonate, Plantacare 818 phosphoric acid hydroxypropyl acrylate sodium, Plantacare 818 hydroxyl Propyl sulfonic acid sodium, -7 sodium citrate of dilauryl polyoxyethylene ether, -10 sodium phosphate of dilauryl polyoxyethylene ether, dilinoleic acid Aminopropyl pg dimonium chloride sodium phosphate, dilinoleic acid sodium, -8 phosphate of two oleic acid disodiums, neopelex, 2- Ethylsulfonic acid sodium ethyl ester, phosphoglycerol enuatrol, grape seed oil amido propyl pg dimonium chloride phosphate, grape pip two Property acetate, grape pip enuatrol, sorbic acid both sexes sodium acetate, Hexeth-4 carboxylic acid sodium, sodium hydride coconut oil sodium, hydrogenated coco Sulfonylmethyl sodium isethionate, hydrogenated palm acid sodium, h-tallow acid sodium, hydrogenated tallow acyl glutamic acid sodium, hydroxy stearate Base dimethyl sodium phosphate ethyl ester, hydroxypropyl palmitate, Hydroxypropyl phosphate sodium Plantacare 818 cross-linked polymer, Hydroxypropyl phosphate Sodium lauryl glucoside cross-linked polymer, hydroxypropyl azochlorosulfonate acid sodium coco glucoside cross-linked polymer, hydroxypropyl azochlorosulfonate acid sodium decyl Portugal It is glucosides cross-linked polymer, hydroxypropyl azochlorosulfonate acid sodium lauryl glucoside cross-linked polymer, hydroxyl sodium stearate, isostearic acid sodium, different It is -6 carboxylic acid sodium of steareth, -11 carboxylic acid sodium of iso stearyl polyoxyethylene ether, isostearoyl both sexes guanidine-acetic acid sodium, different Stearoyl both sexes base sodium propionate, N- isostearic acid N-methyltaurine sodium, lanolin alcohol sulphate sodium, lanolin fatty acid sodium, 12 Sour sodium, lauroyl sodium diacelate, sodium dodecyl aminopropionitrile, sodium laurate, -3 carboxylic acid sodium of laureth 9, poly- second - 4 carboxylic acid sodium of ten diether of glycol list, -5 carboxylic acid sodium of laureth 9, -6 carboxylic acid sodium of laureth 9, poly- second two - 8 carboxylic acid sodium of ten diether of alcohol list, -11 carboxylic acid sodium of laureth 9, -12 carboxylic acid sodium of laureth 9, poly- second two - 13 carboxylic acid sodium of ten diether of alcohol list, -14 carboxylic acid sodium of laureth 9, -16 carboxylic acid sodium of laureth 9, poly- second - 17 carboxylic acid sodium of ten diether of glycol list, NaLS ,-5 sodium sulphate of laureth 9, laureth 9- 7 sodium sulphate ,-8 sodium sulphate of laureth 9 ,-8 sodium sulphate of laureth 9, laureth 9-12 Sodium sulphate, -40 sodium sulphate of laureth 9, -7 sodium tartrate of laureth 9, laurel dipropionic acid Sodium, lauryl both sexes sodium acetate, lauryl both sexes hydroxypropyl sulfonate, lauroyl Sodium L-alaninate, lauroyl methyl ammonia Base sodium propionate, lauroyl methyl thio sodium phosphate, lauroyl methyl sodium sulphate, lauroyl methyl sodium sulphate, lauroyl Ylmethyl sodium sulphate, sodium lauroyl glutamate, lauroyl/myristoyl NaAsp, lauroyl oat amino acid lauroyl Sodium sarcosinate, lauroyl L-Serine sodium, laurel sodium acyl taurine, lauroyl wheat amino acid sodium, dodecyl diethylidene two Amino glycine sodium, lauryl glucose carboxylic acid sodium, Dodecyl Polyglucosides Hydroxypropyl phosphate sodium, Dodecyl Polyglucosides hydroxypropyl Base sodium sulfonate, laurel ethyl glycol carboxylic acid sodium, lauryl hydroxyl acetamide sodium sulphate, lauryl sodium sulfate, dodecyl sulphur Sour sodium, lauryl sodium sulfate, sodium stearyl sulfate, sodium stearyl sulfate, sodium hexadecyl sulfate, dodecyl sulphate Sodium, lauryl sodium sulfate, lauryl sodium sulfate, lauryl sodium sulfate, methyl lauroyl sodium taurocholate, methyl Pork and beans Cool acyl taurines sodium, methyl oleoyl taurate, sodium methyl palmitoyl taurate, methyl stearyl sodium taurocholate, Methyl 2- sulfolauric acid sodium, methyl 2- sulfo group sodium palmitate, the different palmitamide of N-methyltaurine sodium, N-methyltaurine cocounut oil Sulfonylmethyl sodium taurocholate, Sodium myristate, myristyl both sexes sodium acetate, myristoyl sodium glutamate, myristoyl water Solve collagen, myristoyl sodium salicylate, myristoyl-N-methylaminoacetic acid sodium, sodium tetradecyl sulfate, -6 sodium phosphate of nonoxinol, Nonoxynol-9 sodium phosphate, -1 sodium sulphate of nonoxinol, -3 sodium sulphate of nonoxinol, -4 sodium sulphate of nonoxinol, nonoxinol - 6 sodium sulphate, -8 sodium sulphate of nonoxinol, -10 sodium sulphate of nonoxinol, -25 sodium sulphate of nonoxinol, pungent -2 ethane of benzene alcoholic solution Sodium sulfonate, pungent -2 sodium sulphate of benzene alcoholic solution, pungent -6 sodium sulphate of benzene sodium alkoxide, pungent -9 sodium sulphate of benzene sulphur sodium alkoxide, enuatrol, oleoyl both sexes Sodium acetate, oleoyl both sexes hydroxypropyl azochlorosulfonate acid sodium, oleic acid both sexes sodium phosphate enuatrol, enuatrol, sodium palmitate, sodium palmitate, palm fibre Palmitic acid acid sodium, sodium palmitate, sodium palmitate, sodium palmitate, sodium palmitate, sodium palmitate, sodium palmitate, sodium palmitate, palmitinic acid Sodium, Hydrolyzed Collagen, palmityl hydrolyzed wheat protein sodium, palmitoyl sarcosine sodium, sodium palmitate, cocoyl pyrophosphoric acid Sodium, palmityl Sodium L-tyrosinate, palmityl sodium glutamate, theobromic acid sodium, peanut oleoyl both sexes guanidine-acetic acid sodium, arachic acid sodium, PEG-6 coconut oleoyl amine carboxylic acid sodium, PEG-8 coconut oleoyl amine carboxylic acid sodium, PEG-4 coconut oleoyl amine sodium sulphate, PEG-3 lauramide carboxylic acid Sodium, PEG-4 lauramide carboxylic acid sodium, PEG-8 palm glycerides carboxylic acid sodium, pentaerythrite hydroxypropyl iminodiacetic acid sodium tree Branch shape macromolecular, propoxyl group PPG-2 sodium acetate, vegetable seed enuatrol, sodium ricinoleate, ricinoleic acid Sodium Glycinate, fructus rosae Soybean protein, the sesame oil sodium, sesame oleoyl both sexes guanidine-acetic acid that sodium acetate, sodium abietate, safflower acid sodium, safflower acid sodium hydrolyze Sodium, Butyrospermum acyl both sexes guanidine-acetic acid sodium, soy acid sodium, the collagenic acid sodium of soy hydrolysate, odium stearate, stearoyl both sexes base second Sour sodium, stearyl sodium salicylate, stearoyl hydrolytic soya bean protein, stearoyl hydrolyzed wheat protein sodium, stearyl whey egg White sodium, stearyl sodium salicylate, stearoyl sodium salicylate, stearyl sodium salicylate, stearyl sodium salicylate, stearoyl Ylmethyl sodium sulphate, stearoyl avenin, stearoyl pea protein sodium, stearoyl soybean protein sodium, stearyl dimethyl are sweet Propylhomoserin sodium, sodium stearyl sulfate, heronsbill both sexes both sexes sodium acetate, Surfactin sodium, sweet taste diacetyl acetate sodium, sweet tea acid Almond sodium, Carvedilol oleoyl both sexes base sodium propionate, sodium soap, tallow vinegar both sexes guanidine-acetic acid sodium, tallow fatty acid sodium, tallow sodium sulphate, Sodium taurocholate, sodium taurocholate, taurine cocoa ylmethyl sodium taurocholate, taurine sodium taurocholate, sodium/TEA- lauroyl collagen ammonia Base acid, sodium/TEA- lauroyl hydrolytic collagen, sodium/TEA- lauroyl hydrolysis of keratin, sodium/TEA- lauroyl Keratin amino acids, Sodium/TEA- endecatylene acyl collagen amino acid, sodium/TEA- endecatylene acyl hydrolytic collagen, sodium/TEA- endecatylene acyl hydrolysis are beautiful Rice gluten, sodium/TEA- endecatylene acyl hydrolytic soya bean protein, sodium/TEA- endecatylene acyl hydrolyzed wheat protein, tridecyl are poly- - 3 carboxylic acid sodium of ethylene oxide ether, -4 carboxylic acid sodium of Sodium Trideceth, -6 carboxylic acid sodium of Sodium Trideceth, tridecane - 7 carboxylic acid sodium of base polyoxyethylene ether, -8 carboxylic acid sodium of Sodium Trideceth, -12 carboxylic acid sodium of Sodium Trideceth, - 15 carboxylic acid sodium of Sodium Trideceth, -19 carboxylic acid sodium of Sodium Trideceth, tridecyl benzene sulfonate, 13 Sodium alkyl sulfate, tridecyl benzene sulfonate, tridecyl sulfate, trimethylolpropane hydroxypropyl iminodiacetic acid (salt) acid esters Dendritic macromole, undecyl -5- carboxylic acid sodium, sodium undecylenate, undecenyl both sexes sodium acetate, undecenyl two Property sodium propionate, endecatylene acyl sodium glutamate, wheat-based sodium diacelate, -160 tristearate of sorbeth, soy acid, big Beans amidopropyl amine oxide, soy amide propyl betaine, soybean oil stearamide propyl amine oxide, stearamidopropyl Glycine betaine, octadecylamine oxide, stereth -15, stereth -16, stereth -20, stereth -21, Stereth -25, stereth -27, stereth -30, stereth -40, stereth -50, stearyl alcohol Polyethers -80, stereth -100, -2 phosphate of stereth, -3 phosphate of stereth, stearic acid, stearic oxygen third Base trimethyl ammonium chloride, stearoyl-glutamic acid, Hamposyl S, stearyl betaine, stearyl dimethyl hydroxypropyl butyl Glucoside ammonium chloride, stearyl dimethyl hydroxypropyl Plantacare 818 chloride, stearyl dimethyl lauryl glucoside chlorine Compound, sulfurized castor oil, sulphation coconut oil, sulphation glyceryl oleate, sulphation olive oil, sulphation peanut oil, Xiang Certain herbaceous plants with big flowers amide MEA, sunflower seeds acid, sunflower seed oleamidopropyl hydroxyethyl dimethyl ammonium chloride, -8 ester of sunflower oil glyceride, Tall oil acid, tallow fatty acid, butter amidopropyl amine oxide, butter amido propyl betaine, butter amidopropyl hydroxyl Base sulfobetaines, tallow amine oxide, tallow glycine betaine, butter dihydroxy ethyl glycine betaine, C12-14Alkylphosphonic, TEA- C10-15Alkyl sulfate, TEA-C11-15Alkyl sulfate, TEA-C12-13Alkyl sulfate, TEA-C12-14Alkyl sulfate, TEA- C12-15Alkyl sulfate, TEAC14-17TEA- cocounut oil acid esters, TEA- cocoyl diacetate esters, TEA- cocounut oil acid esters, TEA- coconut palm Oil base-sulfuric ester, TEA- cocoyl alanine ester, TEA- cocoyl glutamate ester, TEA- cocoyl glutamate ester, TEA- coconut palm Oil base glycinate, TEA- cocoyl hydrolytic collagen, TEA cocoyl sarcosine salt, TEA- dimethyl silicone polymer PEG-7 phosphorus Hydrochlorate, TEA- dodecyl benzene sulfonate, TEA- hydrogenated coco acid esters, TEA- hydrogenated tallow acyl glutamate, the different tristearin of TEA- Hydrochlorate, TEA- isostearoyl hydrolytic collagen, TEA- Laura aminopropionate, TEA- laurate, TEA- lauric acid/myristic acid Ester, TEA- lauroyl sulfuric ester, TEA- lauroyl collagen amino acid, TEA- lauroyl glutamate ester, TEA- lauroyl Base hydrolytic collagen, TEA- lauroyl Keratin amino acids, TEA- lauroyl methylaminopropionic ester, TEA- lauroyl/asparagus fern Aminoacyl aspartate, Hamposyl L salt, TEA- dodecylphosphoric acid salt, TEA- lauryl sulfate, TEA- Pork and beans Cool amino acid propionate, TEA- myristate, TEA- myristoyl hydrolytic collagen, TEA- oleate, TEA- oleoyl hydrolytic collagen, TEA- oleoyl sarcosinates, TEA- oleyl sulfate, TEA- palmitate, TEA- palm kernel myristinate, TEA-PEG-3 coconut palm Oleamide sulfate, TEA- rosin ester, TEA- stearate, TEA- talcum acid esters, TEA- tridecyl benzene sulfonate, TEA- Undecylenate, TEA- undecylenoyl Hydrolyzed Collagen, tetramethyl decynediol, tetrabasic carboxylic acid ethyl octadecyl sulphur Base Succinamate, TIPA- lauryl sulfate, TIPA- lauryl sulfate, TIPA- myristate, TIPA- are stearic Hydrochlorate, tocopheryl phosphate, three-C12-15- 2 phosphate of Pareth, three-C12-15- 6 phosphate of Pareth, three- C12-15- 8 phosphate of Pareth, three-C12-15- 10 phosphate of Pareth, Sodium Trideceth -20,13 Alkyl polyoxyethylene ether -50, -3 carboxylic acid of Sodium Trideceth, dodecyl polyoxyethylene ether dendritic, ten Dialkyl group polyoxyethylene lauryl base polyoxyethylene ether dendritic macromole, dodecyl polyoxyethylene lauryl base polyoxyethylene Ether dendritic, dodecyl polyoxyethylene lauryl base polyoxyethylene ether dendritic, triethanolamine lauryl acyl PG- acetate chloride phosphate, undecanoic acid, undecenoic acid -5, endecatylene amidopropyl amine oxide, endecatylene amide Propyl betaine, undecenoic acid, endecatylene acyl collagen amino acid, undecenyl glycine, endecatylene undecyl Glucoside, wheat embryo acid, wheat amide propylamine oxide, wheat amide propylamine glycine betaine, west ground Ge Silanye/root/stem Any one or more in extract, west ground lattice yucca stem extraction, copper sulphate zinc and cocounut oil zinc sulfate.
The second aspect of the invention provides the application method of insulin needle surface siliconization inorganic agent as described above, packet It includes, following steps：
(1) each raw material of insulin needle surface siliconization inorganic agent is mixed to get uniform bath foam；
(2) it will be kept at least half a minute in bath foam that needle point is impregnated in (1) step, then taken out；
It (3) is 20~40 DEG C in temperature, relative humidity solidifies 12~24 hours under the conditions of being 55~70%.
The present invention is specifically described below by embodiment.It is necessarily pointed out that following embodiment is only used In the invention will be further described, it should not be understood as limiting the scope of the invention, professional and technical personnel in the field The some nonessential modifications and adaptations made according to the content of aforementioned present invention, still fall within protection scope of the present invention.
In addition, if without other explanations, it is raw materials used to be all commercially available, it is purchased from traditional Chinese medicines chemical reagent.
Embodiment
Embodiment 1
Embodiment 1 provides a kind of insulin needle surface siliconization inorganic agent, the insulin needle surface siliconization inorganic agent, with Parts by weight meter, including organic silicone oil 5, diluent 75.
The silicone oil group that the dimethyl silicone polymer silicone oil and the trade mark that the organic silicone oil is 360 by the DOW CORNING trade mark are 4159 At weight ratio 1：2；The diluent is made of the isopropanol of 10 parts by weight and the ether of 80 parts by weight.
This example additionally provides the application method of the insulin needle surface siliconization inorganic agent, includes the following steps：
(1) each raw material of insulin needle surface siliconization inorganic agent is mixed to get uniform bath foam；
(2) needle point is impregnated in the bath foam in (1) step and is kept for 45 seconds, then taken out；
It (3) is 20 DEG C in temperature, relative humidity solidifies 12 hours under the conditions of being 55%.
Embodiment 2
Embodiment 2 provides a kind of insulin needle surface siliconization inorganic agent, the insulin needle surface siliconization inorganic agent, with Parts by weight meter, including organic silicone oil 10, diluent 90.
The silicone oil group that the dimethyl silicone polymer silicone oil and the trade mark that the organic silicone oil is 360 by the DOW CORNING trade mark are 4159 At weight ratio 2：1；The diluent is made of the isopropanol of 20 parts by weight and the ether of 90 parts by weight.
This example additionally provides the application method of the insulin needle surface siliconization inorganic agent, includes the following steps：
(1) each raw material of insulin needle surface siliconization inorganic agent is mixed to get uniform bath foam；
(2) needle point is impregnated in the bath foam in (1) step and is kept for 45 seconds, then taken out；
It (3) is 40 DEG C in temperature, relative humidity solidifies 24 hours under the conditions of being 70%.
Embodiment 3
Embodiment 3 provides a kind of insulin needle surface siliconization inorganic agent, the insulin needle surface siliconization inorganic agent, with Parts by weight meter, including organic silicone oil 8, diluent 85.
The silicone oil group that the dimethyl silicone polymer silicone oil and the trade mark that the organic silicone oil is 360 by the DOW CORNING trade mark are 4159 At weight ratio 2：1.2；The diluent is made of the isopropanol of 15 parts by weight and the ether of 85 parts by weight.
This example additionally provides the application method of the insulin needle surface siliconization inorganic agent, includes the following steps：
(1) each raw material of insulin needle surface siliconization inorganic agent is mixed to get uniform bath foam；
(2) needle point is impregnated in the bath foam in (1) step and is kept for 45 seconds, then taken out；
It (3) is 25 DEG C in temperature, relative humidity solidifies 24 hours under the conditions of being 60%.
Embodiment 4
Embodiment 4 provides a kind of insulin needle surface siliconization inorganic agent, the insulin needle surface siliconization inorganic agent, with Parts by weight meter, including organic silicone oil 8, diluent 85, surfactant 2.5.
The silicone oil group that the dimethyl silicone polymer silicone oil and the trade mark that the organic silicone oil is 360 by the DOW CORNING trade mark are 4159 At weight ratio 2：1.2；The diluent is made of the isopropanol of 15 parts by weight and the ether of 85 parts by weight；The table Face activating agent is lauryl sodium sulfate.
This example additionally provides the application method of the insulin needle surface siliconization inorganic agent, includes the following steps：
(1) each raw material of insulin needle surface siliconization inorganic agent is mixed to get uniform bath foam；
(2) needle point is impregnated in the bath foam in (1) step and is kept for 45 seconds, then taken out；
It (3) is 25 DEG C in temperature, relative humidity solidifies 24 hours under the conditions of being 60%.
Comparative example 1
Comparative example 1 provides a kind of insulin needle surface siliconization inorganic agent, the insulin needle surface siliconization inorganic agent, with Parts by weight meter, including organic silicone oil 8, diluent 85, surfactant 2.5.
The dimethyl silicone polymer silicone oil that the organic silicone oil is 360 by the DOW CORNING trade mark；The diluent is by 15 weight The isopropanol of part and the ether composition of 85 parts by weight；The surfactant is lauryl sodium sulfate.
This example additionally provides the application method of the insulin needle surface siliconization inorganic agent, includes the following steps：
(1) each raw material of insulin needle surface siliconization inorganic agent is mixed to get uniform bath foam；
(2) needle point is impregnated in the bath foam in (1) step and is kept for 45 seconds, then taken out；
It (3) is 25 DEG C in temperature, relative humidity solidifies 24 hours under the conditions of being 60%.
Comparative example 2
Comparative example 2 provides a kind of insulin needle surface siliconization inorganic agent, the insulin needle surface siliconization inorganic agent, with Parts by weight meter, including organic silicone oil 8, diluent 85, surfactant 2.5.
The organic silicone oil is that 4159 silicone oil form by the DOW CORNING trade mark；The diluent by 15 parts by weight isopropanol and The ether of 85 parts by weight forms；The surfactant is lauryl sodium sulfate.
This example additionally provides the application method of the insulin needle surface siliconization inorganic agent, includes the following steps：
(1) each raw material of insulin needle surface siliconization inorganic agent is mixed to get uniform bath foam；
(2) needle point is impregnated in the bath foam in (1) step and is kept for 45 seconds, then taken out；
It (3) is 25 DEG C in temperature, relative humidity solidifies 24 hours under the conditions of being 60%.
Performance evaluation
The insulin needle surface siliconization inorganic agent that the embodiment of the present invention 1~4 provides carries out at surface siliconization insulin needle The frictional resistance being substantially reduced in acupuncture course after reason brings Painfree needle to pierce experience sense to the person of being needled, and wherein embodiment 4 mentions This effect is most obvious when the insulin needle surface siliconization inorganic agent of confession pierces needle after insulin needle progress surface siliconization processing. And the insulin needle that the inorganic agent for using comparative example 1~2 to provide obtains after being handled will not bring significant Painfree needle to pierce Sense.
The above described is only a preferred embodiment of the present invention, being not that the invention has other forms of limitations, appoint What those skilled in the art changed or be modified as possibly also with the technology contents of above-mentioned enlightenment equivalent variations etc. Imitate embodiment.But everything is without departing from technical solution of the present invention content, according to the technical essence of the invention to above embodiments institute The simple modification made, equivalent variations and remodeling, still fall within the protection scope of technical solution of the present invention.

Claims (10)

1. a kind of insulin needle surface siliconization inorganic agent, which is characterized in that the insulin needle surface siliconization inorganic agent, with weight Part meter, including organic silicone oil 5~10, diluent 75~90.
2. insulin needle surface siliconization inorganic agent as described in claim 1, which is characterized in that the organic silicone oil includes poly- two Methylsiloxane and functional siloxane.
3. insulin needle surface siliconization inorganic agent as claimed in claim 2, which is characterized in that the dimethyl silicone polymer Kinematic viscosity is 350~1500cSt.
4. insulin needle surface siliconization inorganic agent as claimed in claim 2, which is characterized in that the functional siloxane strand In contain reactive methylol.
5. insulin needle surface siliconization inorganic agent as claimed in claim 4, which is characterized in that the functional siloxane strand In also contain primaquine group.
6. insulin needle surface siliconization inorganic agent as claimed in claim 5, which is characterized in that the functional siloxane strand In also contain secondary amino group.
7. insulin needle surface siliconization inorganic agent as described in claim 1, which is characterized in that the diluent is by 80~90 weights Measure the nonpolar solvent of part and the polar solvent composition of 10~20 parts by weight.
8. insulin needle surface siliconization inorganic agent as claimed in claim 7, which is characterized in that the diluent is by 85 parts by weight Nonpolar solvent and 15 parts by weight polar solvent composition.
9. insulin needle surface siliconization inorganic agent as described in claim 1, which is characterized in that the insulin needle surface siliconization Inorganic agent further includes the surfactant of 1~3 parts by weight.
10. the application method of insulin needle surface siliconization inorganic agent as claimed in any one of claims 1 to 9 wherein, feature exist In, including, following steps：
(1) each raw material of insulin needle surface siliconization inorganic agent is mixed to get uniform bath foam；
(2) it will be kept at least half a minute in bath foam that needle point is impregnated in (1) step, then taken out；
It (3) is 20~40 DEG C in temperature, relative humidity solidifies 12~24 hours under the conditions of being 55~70%.
CN201811141510.5A 2018-09-28 2018-09-28 A kind of insulin needle surface siliconization inorganic agent Pending CN108853607A (en)

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5911711A (en) * 1998-06-29 1999-06-15 Becton, Dickinson And Company Lubricant system for hypodermic needles and method for its application
CN1684726A (en) * 2002-07-24 2005-10-19 舍伍德服务公开股份有限公司 Medical device lubricant comprising radiation curable silicon material
CN1978566A (en) * 2005-12-08 2007-06-13 上海康德莱企业发展集团有限公司 Needle head siliconizing keagent, and its siliconizing method
CN106039423A (en) * 2016-06-02 2016-10-26 江苏吉春医用器材有限公司 Silicification liquid for injector needle tip
CN106221976A (en) * 2016-07-26 2016-12-14 温州科技职业学院 A kind of insulin needle surface siliconization inorganic agent
CN108310473A (en) * 2018-01-31 2018-07-24 采纳科技股份有限公司 Injection needle silicone coating material and the injection needle for coating this coating

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5911711A (en) * 1998-06-29 1999-06-15 Becton, Dickinson And Company Lubricant system for hypodermic needles and method for its application
CN1684726A (en) * 2002-07-24 2005-10-19 舍伍德服务公开股份有限公司 Medical device lubricant comprising radiation curable silicon material
CN1978566A (en) * 2005-12-08 2007-06-13 上海康德莱企业发展集团有限公司 Needle head siliconizing keagent, and its siliconizing method
CN106039423A (en) * 2016-06-02 2016-10-26 江苏吉春医用器材有限公司 Silicification liquid for injector needle tip
CN106221976A (en) * 2016-07-26 2016-12-14 温州科技职业学院 A kind of insulin needle surface siliconization inorganic agent
CN108310473A (en) * 2018-01-31 2018-07-24 采纳科技股份有限公司 Injection needle silicone coating material and the injection needle for coating this coating

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