CN108836882A - A kind of lipoid plastid and composite skin care product with whitening spot-removing function - Google Patents
A kind of lipoid plastid and composite skin care product with whitening spot-removing function Download PDFInfo
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Abstract
The invention discloses a kind of lipoid plastid and composite skin care product with whitening spot-removing function.Lipoid plastid of the invention has multilayer phospholipid bilayer, is specifically made of the raw material of following weight percent：Compound whitening spot-removing ingredient：10%~40%；Soybean lecithin：10%~25%；Sodium Hyaluronate：0.1%~5%；Hydrolytic collagen：0.1%~5%；Grease：0.1%~5%；Water：Surplus.Lipoid plastid as described above is added in composite skin care product of the invention.Not only whitening spot-removing effect is good for lipoid plastid and composite skin care product of the invention, but also helps to increase skin elasticity and water content of stratum corneum, and preparation process is simple, is appropriate for industrialization large-scale production.
Description
Technical field
The present invention relates to a kind of lipoid plastid and composite skin care product with whitening spot-removing function.
Background technique
Skin is made of epidermis, corium and subcutaneous tissue three-decker.Epidermis is outmost one layer of skin, from outside to inside
Five layers can be divided into again：Cuticula, hyaline layer, stratum granulosum, stratum aculeatum and basal layer.Cuticula is located at epidermis outermost layer, by 4~8
The flat cytode of layer is constituted；Hyaline layer is made of 2~4 layers of flat cytode；Stratum granulosum is thin by 2~4 layers of shuttle shape or diamond shape
Born of the same parents are constituted；Stratum aculeatum is by 4~8 layers of polygonal cell composition；Basal layer is located at epidermis bosom, by single layer cylindrical cell structure
At.Melanocyte is also known as dentritic cell, is predominantly located at basal layer, accounts for the 4%~10% of entire basal layer cell, function
It is mature melanin to be passed into keratinocyte, and then play a protective role.Skin color is total to by gene and environment
With what is determined, everyone melanocyte quantity variance is little in fact, but the yield of melanin is different with distribution, just causes
Colour of skin difference.
Whitening and skin-protecting is usually started in terms of following three：Inhibit melanin to be formed, interfere melanin transfer and accelerate black
Pigment degradation.Common whitening spot-removing ingredient mainly has vitamin C and its derivative, arbutin, kojic acid, tartaric acid, natural herb
Class, Trenaxmine, niacinamide, Symwhite-337, undecylenoyl phenylalanine, fullerene etc..Wherein, arbutin, song
Acid, natural herb class, Symwhite-337 and undecylenoyl phenylalanine can inhibit melanin to be formed, niacinamide and
Tartaric acid can accelerate cutin to form cell metabolism, and the keratinocyte containing melanin is promoted to fall off, and inhibit melanin transfer,
Vitamin C and its derivative, natural herb class, Trenaxmine and fullerene have stronger reproducibility, in addition to that can inhibit black
Pigment is formed, and established melanin can also be restored.The effect of single whitening spot-removing ingredient, is limited, and is oxidized easily and loses
Whitening function, and a variety of whitening spot-removing ingredients are applied in combination can play synergistic function.
Liposome is a kind of double-deck rouge molecule spherical vesicles, and 25~1000nm of diameter is differed, it can and cell membrane fusion,
Content is sent into cell interior, so being usually used in medically preparing drug or other biological engineering.
Arbutin also known as Arbutin, white acicular crystal or powder, it can rapidly permeate into skin, not influence cell
While being proliferated concentration, it can effectively inhibit the activity of tyrosinase in skin, block the formation of melanin, it can also be with junket ammonia
Sour enzyme combines, and accelerates the decomposition and excretion of melanin, so that Skin pigmentation is reduced, dispelling stain and freckle, and will not be right
Melanocyte generates the side effects such as toxic, irritation, sensitization.Arbutin is divided into alpha-arbutin, β-arbutin and deoxidation
Three kinds of arbutin.In the case where guaranteeing 95% cell survival, the effect that deoxyarbutin inhibits tyrosinase activity is best, is
10 times of quinhydrones, 38.5 times of alpha-arbutin, 350 times of β-arbutin, and 4 times bigger than quinhydrones of safe concentration or more, but deoxidation
Arbutin is easy to decompose under light conditions.
Fullerene also known as football alkene are made of 60 carbon atoms, and oxidation resistance is extremely strong, are ascorbic 172 times, and
And can Scavenger of ROS, even if still can stablize the potent antioxidation of performance under ultraviolet light irradiation.Fullerene can be with
The various damages for blocking free radical to generate skin from source have multiple skin makeup effect, such as：Whitening, crease-resistant, treatment is green
Spring acne, promotion hair growth, careful pore and moisturizing etc..
Summary of the invention
The purpose of the present invention is to provide a kind of lipoid plastid and composite skin care product with whitening spot-removing function.
The technical solution adopted by the present invention is that：
A kind of lipoid plastid with whitening spot-removing function, with multilayer phospholipid bilayer, specifically by following weight
The raw material of percentage is made：
Compound whitening spot-removing ingredient：10%~40%；
Soybean lecithin：10%~25%；
Sodium Hyaluronate：0.1%~5%；
Hydrolytic collagen：0.1%~5%；
Grease：0.1%~5%；
Water：Surplus.
The phospholipid bilayer has 12~24 layers.
The partial size of the lipoid plastid is 500~1000nm.
The compounding whitening spot-removing ingredient is by deoxyarbutin, niacinamide, vitamin C, water-soluble fullerene, glycyrrhiza glabra
Extract, mulberry tree root extract and rice tunning compound.
The water-soluble fullerene is surface through the processed fullerene of polyvinyl pyrrolidone modified.
The Sodium Hyaluronate is the digestion oligomerization Sodium Hyaluronate that molecular weight is less than 10000Da.
The grease is compounded by ceramide, tocopherol acetate, saualane, cod-liver oil and jojoba oil.
The preparation method of the above-mentioned lipoid plastid with whitening spot-removing function, includes the following steps：
1) Sodium Hyaluronate, hydrolytic collagen and water are uniformly mixed at 60~70 DEG C, obtain buffer solution；
2) a part of buffer solution is taken, compounding whitening spot-removing ingredient is added, is uniformly mixed at 40~50 DEG C, obtains content
Liquid；
3) soybean lecithin and grease are uniformly mixed, then evaporated under reduced pressure at 40~50 DEG C, obtain phospholipid membrane；
4) a part of phospholipid membrane is taken, content liquid is added, obtains single layer package using supercritical fluid reverse evaporation
Lipoid plastid；
5) lipoid plastid for taking a part of buffer solution dispersion single layer package, adds a part of phospholipid membrane, utilization is thin
Film extrusion obtains the lipoid plastid of double wrapped, repeats the operation, obtains the lipoid plastid of multilayer package, then with hollow fibre
Dimension ultrafiltration membrane is filtered for multiple times, and is removed partial size and is less than 500nm and the lipoid plastid greater than 1000nm, obtains with whitening spot-removing
The lipoid plastid of function.
A kind of composite skin care product with whitening spot-removing function, is made of the raw material of following weight percent：
Lipoid plastid as described above：15%~25%；
Glycerol：2%~7%；
Butanediol：2%~6%；
Glycine betaine：2%~4%；
Purslane extract：0.1%~0.3%；
Carbomer：0.1%~0.3%；
Arginine：0.1%~0.3%；
Gorgonian extract：0.1%~0.3%；
Panthenol：0.3%~0.7%；
Hexylene glycol：0.3%~0.7%；
Pungent glycol：0.3%~0.7%；
Phenoxyethanol：0.4%~0.7%；
Water：Surplus.
A kind of composite skin care product with whitening spot-removing function, is made of the raw material of following weight percent：
A phase：
Glycerol：4%~6%；
Butanediol：2%~4%；
Glycerin polyether -26：2%~4%；
Carbomer：0.1%~0.3%；
Water：Surplus；
B phase：
Cocoyl glucoside：0.3%~0.7%；
Stearine：0.3%~0.7%；
Cetostearyl alcohol：0.3%~0.7%；
Ethylhexyl palmitate：2%~6%；
Caprylic/capric triglyceride：2%~4%；
Butyrospermum parkii fruit rouge：0.5%~1.5%；
C phase：
Panthenol：0.3%~0.7%；
Purslane extract：0.1%~0.2%；
Arginine：0.1%~0.2%；
Hexylene glycol：0.3%~0.7%；
Pungent glycol：0.3%~0.7%；
Phenoxyethanol：0.4%~0.7%；
Gorgonian extract：0.3%~0.7%；
Lipoid plastid as described above：15%~20%.
The beneficial effects of the invention are as follows：Not only whitening spot-removing effect is good for lipoid plastid and composite skin care product of the invention,
And help to increase skin elasticity and water content of stratum corneum, preparation process is simple, is appropriate for industrialization large-scale production.
1) lipoid plastid of the invention wraps up whitening spot-removing ingredient by multiple phospholipid bilayer, not only can be to avoid
Whitening spot-removing ingredient oxygenolysis or illumination are decomposed, and are also solved traditional single layer phospholipid bilayer wrappage and permeated
Easily rupturable the problem of discharging in advance in the process, enable the deep enough basal layer of whitening spot-removing ingredient, significantly improves whitening spot-removing
Effect；
2) lipoid plastid of the invention has amphiphilic, can be applied in most cosmetics；
3) it is enclosed with compounding whitening spot-removing ingredient in lipoid plastid of the invention, has between each whitening spot-removing ingredient good
Complementation, synergistic effect, can from inhibit melanin formed, interference melanin transfer and accelerate melanin degrade three aspect together
When start with and eliminate melanin, whitening spot-removing effect is more excellent；
4) it is enclosed with Sodium Hyaluronate, hydrolytic collagen and grease in lipoid plastid of the invention, helps to increase skin bullet
Property and water content of stratum corneum；
5) present invention screens lipoid plastid by Ultra filtration membrane technology, by size controlling 500~
1000nm facilitates lipoid plastid and preferably penetrates to the skin that (partial size of lipoid plastid is too big, then is unfavorable for permeating for epidermis internal layer
It absorbs；The partial size of lipoid plastid is too small, then self stability is poor).
Specific embodiment
A kind of lipoid plastid with whitening spot-removing function, with multilayer phospholipid bilayer, specifically by following weight
The raw material of percentage is made：
Compound whitening spot-removing ingredient：10%~40%；
Soybean lecithin：10%~25%；
Sodium Hyaluronate：0.1%~5%；
Hydrolytic collagen：0.1%~5%；
Grease：0.1%~5%；
Water：Surplus.
It is further preferred that a kind of lipoid plastid with whitening spot-removing function, with multilayer phospholipid bilayer, tool
Body is made of the raw material of following weight percent：
Compound whitening spot-removing ingredient：35%~40%；
Soybean lecithin：20%~25%；
Sodium Hyaluronate：0.3%~0.7%；
Hydrolytic collagen：0.3%~0.7%；
Grease：4%~5%；
Water：Surplus.
Preferably, the phospholipid bilayer has 12~24 layers.
Preferably, the partial size of the lipoid plastid is 500~1000nm.
Preferably, the compounding whitening spot-removing ingredient by deoxyarbutin, niacinamide, vitamin C, water-soluble fullerene,
Glycyrrhiza glabra extract, mulberry tree root extract and rice tunning compound.
It is further preferred that the compounding whitening spot-removing ingredient is by deoxyarbutin, niacinamide, vitamin C, water-soluble richness
Alkene, glycyrrhiza glabra extract, mulberry tree root extract and rice tunning are strangled according to mass ratio 1：(0.5~0.9)：(0.3~
0.4)：(0.3~0.5)：(0.3~0.5)：(0.3~0.5)：(0.4~0.6) compounds.
Preferably, the water-soluble fullerene is surface through the processed fullerene of polyvinyl pyrrolidone modified.
Preferably, the Sodium Hyaluronate is the digestion oligomerization Sodium Hyaluronate that molecular weight is less than 10000Da.
Preferably, the grease by ceramide, tocopherol acetate, saualane, cod-liver oil and jojoba oil compound and
At.
The preparation method of the above-mentioned lipoid plastid with whitening spot-removing function, includes the following steps：
1) Sodium Hyaluronate, hydrolytic collagen and water are uniformly mixed at 60~70 DEG C, obtain buffer solution；
2) a part of buffer solution is taken, compounding whitening spot-removing ingredient is added, is uniformly mixed at 40~50 DEG C, obtains content
Liquid；
3) soybean lecithin and grease are uniformly mixed, then evaporated under reduced pressure at 40~50 DEG C, obtain phospholipid membrane；
4) a part of phospholipid membrane is taken, content liquid is added, obtains single layer package using supercritical fluid reverse evaporation
Lipoid plastid；
5) lipoid plastid for taking a part of buffer solution dispersion single layer package, adds a part of phospholipid membrane, utilization is thin
Film extrusion obtains the lipoid plastid of double wrapped, repeats the operation, obtains the lipoid plastid of multilayer package, then with hollow fibre
Dimension ultrafiltration membrane is filtered for multiple times, and is removed partial size and is less than 500nm and the lipoid plastid greater than 1000nm, obtains with whitening spot-removing
The lipoid plastid of function.
A kind of composite skin care product with whitening spot-removing function, is made of the raw material of following weight percent：Institute as above
The lipoid plastid stated：15%~25%；
Glycerol：2%~7%；
Butanediol：2%~6%；
Glycine betaine：2%~4%；
Purslane extract：0.1%~0.3%；
Carbomer：0.1%~0.3%；
Arginine：0.1%~0.3%；
Gorgonian extract：0.1%~0.3%；
Panthenol：0.3%~0.7%；
Hexylene glycol：0.3%~0.7%；
Pungent glycol：0.3%~0.7%；
Phenoxyethanol：0.4%~0.7%；
Water：Surplus.
A kind of composite skin care product with whitening spot-removing function, is made of the raw material of following weight percent：A phase：
Glycerol：4%~6%；
Butanediol：2%~4%；
Glycerin polyether -26：2%~4%；
Carbomer：0.1%~0.3%；
Water：Surplus；
B phase：
Cocoyl glucoside：0.3%~0.7%；
Stearine：0.3%~0.7%；
Cetostearyl alcohol：0.3%~0.7%；
Ethylhexyl palmitate：2%~6%；
Caprylic/capric triglyceride：2%~4%；
Butyrospermum parkii fruit rouge：0.5%~1.5%；
C phase：
Panthenol：0.3%~0.7%；
Purslane extract：0.1%~0.2%；
Arginine：0.1%~0.2%；
Hexylene glycol：0.3%~0.7%；
Pungent glycol：0.3%~0.7%；
Phenoxyethanol：0.4%~0.7%；
Gorgonian extract：0.3%~0.7%；
Lipoid plastid as described above：15%~20%.
The present invention will be further explained combined with specific embodiments below and explanation.
Embodiment 1：
A kind of lipoid plastid with whitening spot-removing function has 12 layers of phospholipid bilayer, specific raw material composition
As shown in the table：
A kind of raw material of the lipoid plastid with whitening spot-removing function of table 1 forms table
Embodiment 2：
A kind of lipoid plastid with whitening spot-removing function has 15 layers of phospholipid bilayer, specific raw material composition
As shown in the table：
A kind of raw material of the lipoid plastid with whitening spot-removing function of table 2 forms table
Embodiment 3：
A kind of lipoid plastid with whitening spot-removing function has 20 layers of phospholipid bilayer, specific raw material composition
As shown in the table：
A kind of raw material of the lipoid plastid with whitening spot-removing function of table 3 forms table
Embodiment 4：
A kind of lipoid plastid with whitening spot-removing function has 24 layers of phospholipid bilayer, specific raw material composition
As shown in the table：
A kind of raw material of the lipoid plastid with whitening spot-removing function of table 4 forms table
Embodiment 5：
A kind of composite skin care product (smoothing toner) with whitening spot-removing function, raw material composition are as shown in the table：
A kind of raw material of the composite skin care product with whitening spot-removing function of table 5 forms table
| Raw material | Weight percent (%) |
| The lipoid plastid of embodiment 1 | 20 |
| Glycerol | 5 |
| Butanediol | 4 |
| Glycine betaine | 3 |
| Purslane extract | 0.1 |
| Carbomer | 0.1 |
| Arginine | 0.1 |
| Gorgonian extract | 0.1 |
| Panthenol | 0.5 |
| Hexylene glycol | 0.5 |
| Pungent glycol | 0.5 |
| Phenoxyethanol | 0.6 |
| Deionized water | 65.5 |
The preparation method of above-mentioned composite skin care product is as follows：Above-mentioned each component is accurately weighed, is sequentially added in deionized water,
It is uniformly mixed.
Embodiment 6：
A kind of composite skin care product (lotion) with whitening spot-removing function, raw material composition are as shown in the table：
A kind of raw material of the composite skin care product with whitening spot-removing function of table 6 forms table
The preparation method of above-mentioned composite skin care product is as follows：
1) each component in precise A phase is heated to 75~80 DEG C and stirs evenly, spare；
2) each component in precise B is heated to 75~80 DEG C and stirs evenly, spare；
3) A being added to emulsion pot, temperature maintains 80 DEG C, opens homogeneous and stirring, and mixing speed is 30 turns/min, then
B phase is slowly added into emulsion pot, homogeneous 5min, then persistently insulated and stirred 20min；
4) temperature of material in emulsion pot is down to 40 DEG C, then emulsion pot is added in each component in C phase, lasting stirring is equal
It is even, it is cooled to room temperature.
Comparative example 1：
A kind of lipoid plastid of single layer cladding, raw material composition is identical with embodiment 1, and preparation method is as follows：
1) by Sodium Hyaluronate, hydrolytic collagen, deionized water, deoxyarbutin, niacinamide, vitamin C, water-soluble fowler
Alkene, glycyrrhiza glabra extract, mulberry tree root extract and the mixing of rice tunning, stirring and dissolving is uniform at 40~50 DEG C, obtains
To content liquid；
2) soybean lecithin, ceramide, tocopherol acetate, saualane, cod-liver oil and jojoba oil are mixed, 40~
Stirring and dissolving is uniform at 50 DEG C, then evaporated under reduced pressure, obtains phospholipid membrane；
3) content liquid is added in phospholipid membrane, obtains the lipoids of single layer cladding using supercritical fluid reverse evaporation
Body.Comparative example 2：
A kind of common whitening spot-eliminating composition, raw material composition are as shown in the table：
A kind of raw material of the common whitening spot-eliminating composition of table 7 forms table
The preparation method of above-mentioned common whitening spot-eliminating composition is as follows：Accurately weigh above-mentioned each component, sequentially add from
In sub- water, 40~50 DEG C are uniformly mixed.
Comparative example 3：
A kind of composite skin care product (smoothing toner), in addition to addition be comparative example 1 single layer cladding lipoid plastid other than,
It is remaining identical with embodiment 5.
Comparative example 4：
A kind of composite skin care product (smoothing toner), in addition to addition be comparative example 2 common whitening spot-eliminating composition other than,
It is remaining identical with embodiment 5.
Comparative example 5：
A kind of composite skin care product (lotion), in addition to addition be comparative example 1 single layer cladding lipoid plastid other than, remaining
It is identical with embodiment 6.
Comparative example 6：
A kind of composite skin care product (lotion), in addition to addition be comparative example 2 common whitening spot-eliminating composition other than, remaining
It is identical with embodiment 6.
Test case：
1) different whitening spot-removing ingredients test the maximum inhibition of tyrosinase：
Test sample：The sample solution containing whitening spot-removing ingredient prepared with the phosphate buffer solution of pH=6.8.
Test philosophy：Since l-tyrosine can be catalyzed into levodopa by tyrosinase, and further it is catalyzed into DOPA
Quinone so the absorption value using DOPA quinone in UV-visible region can measure the concentration variation of DOPA quinone, and then obtains tyrosine
The maximum inhibition of enzyme.
Testing procedure：It takes 3mL sample solution to be added in test tube respectively, is set as sample sets and sample controls group, every group each
Contain 3 sample tubes；It takes 3mL phosphate buffer solution to be added in test tube, is set as blank group and blank control group, every group each
Contain 3 sample tubes；The levodopa solution and 0.5mL concentration of 0.5mL concentration 0.02mol/L are added in each group test tube
The l-tyrosine solution of 0.02mol/L, concussion shake up, constant temperature 10min under the conditions of 30 DEG C；Respectively add in sample sets and blank group
The tyrosine enzyme solution for entering 0.5mL concentration 0.35mol/L, is respectively added 0.5mL phosphate in sample controls group and blank control group
Buffer solution, concussion shake up, the reaction was continued 5min, and light absorption value is then measured at wavelength 475nm with spectrophotometer.
Inhibitory activity against tyrosinase is calculated according to the following formula：
In formula, M1For sample sets absorption value, M0For sample controls group absorption value, N1For blank group absorption value, N0For blank pair
According to a group absorption value.
Different whitening spot-removing ingredients are as shown in the table to the maximum inhibition of tyrosinase：
Maximum inhibition test result of the different whitening spot-removing ingredients of table 8 to tyrosinase
As shown in Table 8：Different whitening spot-removing ingredients is used in compounding in ratio of the present invention can obtain preferably
The effect inhibited tyrosinase activity, inhibiting rate can achieve 80% or more, compare with using single whitening spot-removing ingredient, effect
It is obviously improved, illustrates that there is good complementary, synergistic effect between each whitening spot-removing ingredient.
2) different whitening spot-removing ingredients test the reduction rate of melanin：
Test sample：The sample solution containing whitening spot-removing ingredient prepared with the phosphate buffer solution of pH=6.8.
Test philosophy：Since melanin has the ability for absorbing ultraviolet light, the absorption using melanin in UV-visible region
Value can measure the concentration variation of melanin, and then obtain melanin reduction rate.
Test procedure：It takes 3mL sample solution to be added in test tube respectively, is set as sample sets and sample controls group, every group each
Contain 3 sample tubes；It takes 3mL phosphate buffer solution to be added in test tube, is set as blank group and blank control group, every group each
Contain 3 sample tubes；The melanin solution of 500 μ g/mL of 1mL concentration is added in each group test tube, concussion shakes up, in 35 DEG C of items
Then constant temperature 30min under part measures light absorption value with spectrophotometer at wavelength 400nm.
Inhibitory activity against tyrosinase is calculated according to the following formula：
In formula, B1For sample sets absorption value, B0For sample controls group absorption value, A1For blank group absorption value, A0For blank pair
According to a group absorption value.
Different whitening spot-removing ingredients are as shown in the table to the reduction rate of melanin：
Reduction rate test result of the different whitening spot-removing ingredients of table 9 to melanin
As shown in Table 9：Different whitening spot-removing ingredients is used in compounding going back for melanin in ratio of the present invention
Former function and effect are better than using single whitening spot-removing ingredient, illustrate there is good complementary, collaboration between each whitening spot-removing ingredient
Effect.
3) the assimilation effect test of whitening spot-removing ingredient：
Test sample：The lipoid plastid of 12 layers of package prepared by embodiment 1, material composition and proportion referring to embodiment 1
The lipoid plastid of 20 layers of package of the lipoid plastid of 15 layers of package of preparation, the material composition of reference embodiment 1 and proportion preparation,
Referring to the class of single layer cladding prepared by the lipoid plastid of 24 layers of package of the material composition and proportion preparation of embodiment 1, comparative example 1
Common whitening spot-eliminating composition prepared by liposome, comparative example 2.
Test method：12 layers wrap up lipoid plastids, 15 layers package lipoid plastids, 20 layers package lipoid plastids,
Fluorescein is set in the lipoid plastid of the single layer cladding of 24 layers of lipoid plastid wrapped up and comparative example 1,1mL is taken uniformly to be applied to people
It makes on skin, after 12h is cultivated, fluorescein is measured, determine transdermal absorption factor and arrive at basal layer accounting rate；It takes
Common whitening spot-eliminating composition prepared by 1mL comparative example 2, is uniformly applied on artificial skin, after 12h is cultivated, scrapes skin
The remaining whitening spot-eliminating composition in skin surface layer calculates average transdermal absorption factor using high effective liquid chromatography for measuring residual components,
Then basal layer artificial skin is intercepted, through crushing, dissolution, filtering, utilizes high effective liquid chromatography for measuring whitening spot-removing ingredient, meter
It calculates and arrives at basal layer accounting rate.
Test result is as follows for the assimilation effect of whitening spot-removing ingredient shown in table：
The assimilation effect test result of 10 whitening spot-removing ingredient of table
As shown in Table 10：Whitening spot-removing ingredient transdermal absorption factor after phospholipid bilayer wraps up is all 80% or more
Twice of common whitening spot-eliminating composition, and the number of plies accounting rates for arriving at basal layer of the phospholipid bilayer wrapped up more more
Height, but the partial size for wrapping up the number of plies more multiclass liposome is bigger, and transdermal absorption factor can be declined；It dispels by the whitening of multiple package
The arrival basal layer accounting rate of spot ingredient is higher by about one time than the whitening spot-removing ingredient that single layer wraps up.Illustrate lipoids of the invention
Body chooses 12~24 layers of the package number of plies, control 500~1000nm of partial size, can obtain very high transdermal absorption factor and take
Very high arrival basal layer accounting rate is obtained, can effectively improve the function and effect of whitening spot-removing ingredient, is reduced in process of osmosis
Loss.
4) stability test：
Test sample：The lipoid plastid of Examples 1 to 4；Skin care item group prepared by embodiment 5, comparative example 3 and comparative example 4
It closes object (smoothing toner)；Composite skin care product (lotion) prepared by embodiment 6, comparative example 5 and comparative example 6；Blank whitening and smoothing toner
(replacing lipoid plastid with the deionized water of equivalent, remaining component is identical with embodiment 5)；Blank emulsion is (with going for equivalent
Ionized water replaces lipoid plastid, remaining component is identical with embodiment 6).
Test method：Test sample is packed into colorimetric cylinder, 6 groups of experimental groups are respectively set in each sample, take 2 groups of carry out slight
It solar illumination 28 days, takes 2 groups of room temperature to be protected from light storage 28 days, takes 2 groups successively to carry out 45 DEG C of storages 3 days, 10 DEG C of storages 2 days and room temperature
Storage 2 days, and 4 heat-resisting cold-resistant circulations are carried out according to this, then observe sample discoloration degree degree.
Stability test result is as shown in the table：
11 stability test result of table
| Sample | Slight solar illumination | Room temperature is protected from light storage | It is heat-resisting cold-resistant |
| Embodiment 1 | Color is unchanged | Color is unchanged | Color is unchanged |
| Embodiment 5 | Color is unchanged | Color is unchanged | Color is unchanged |
| Embodiment 6 | Color is unchanged | Color is unchanged | Color is unchanged |
| Comparative example 1 | Light discolouration | Light discolouration | Color is unchanged |
| Comparative example 2 | Serious discoloration | Obvious discoloration | Light discolouration |
| Comparative example 3 | Light discolouration | Light discolouration | Color is unchanged |
| Comparative example 4 | Serious discoloration | Obvious discoloration | Light discolouration |
| Comparative example 5 | Light discolouration | Light discolouration | Color is unchanged |
| Comparative example 6 | Serious discoloration | Obvious discoloration | Light discolouration |
| Blank whitening and smoothing toner | Color is unchanged | Color is unchanged | Color is unchanged |
| Blank whitening emulsion | Color is unchanged | Color is unchanged | Color is unchanged |
As shown in Table 11：The lipoid plastid and common whitening spot-eliminating composition of single layer cladding are followed by illumination and heat-resisting resist cold
All there is discoloration in ring, and comparatively the discoloration of the lipoid plastid of single layer cladding is smaller；By the class of multiple package
Liposome color as blank control group is unchanged.Illustrate that the lipoid plastid with whitening spot-removing function of the invention has very
Good stability.
5) whitening effect is tested：
Test sample：Composite skin care product (smoothing toner) prepared by embodiment 5, comparative example 3 and comparative example 4；Embodiment 6,
Composite skin care product (lotion) prepared by comparative example 5 and comparative example 6；Commercially available whitening lotion；Commercially available whitening emulsion.
Test object：Choose that 168 colours of skin are partially deep, the volunteer without allergies, men and women's accounting 1:2,8 groups are randomly divided into,
Every group of 21 people, men and women's accounting 1:2.
Test method：8 groups of volunteers use above-mentioned 8 kinds of test samples respectively, respectively use once after daily morning and evening face cleaning, even
It is continuous to use 12 weeks, it during which avoids using German CK company dermal melanin tester MEXAMETERMX using other cosmetics
18 probes measure three times in the quantity of the same position measurement melanin of face, exclude different item, be averaged, surveyed within every 4 weeks
Examination；The content of deactivated melanin after a week is tested simultaneously as a comparison；Changing value is the 12nd week and the preceding 0th week difference of use
Value.
Test result is as follows for whitening effect shown in table：
12 whitening effect test result of table
As shown in Table 12：The whitening effect of embodiment 5 and embodiment 6 is the most prominent, and volunteer used by 12 weeks, black
It is the most obvious that cellulose content reduces effect.Illustrate that the present invention wraps up whitening spot-removing ingredient by multiple phospholipid bilayer, it can be with
The osmotic absorption for effectively facilitating whitening spot-removing ingredient reaches better whitening effect.
6) skin elasticity is tested：
Test sample：Composite skin care product (smoothing toner) prepared by embodiment 5, comparative example 3 and comparative example 4；Embodiment 6,
Composite skin care product (lotion) prepared by comparative example 5 and comparative example 6；Commercially available whitening lotion；Commercially available whitening emulsion.
Test object：160 female volunteers, age are 35 years old, and health is randomly divided into 8 groups.
Test equipment：Reviscometer RV600 (the elastomer of German CK company skin elasticity tester MPA580
Tested tissue probe), it surveys five times and is averaged.
Test condition：1) indoor environment；2) without sunburst or light direct projection；3) 20 ± 2 DEG C of environment temperature, ambient humidity
40%~60%.
Test zone：Left cheekbone portion.
Testing procedure：First measure the blank value (R of 30min after being tested region clean2、R5、R7), then provide volunteer
Adhered to sooner or later daily using test sample, test zone skin elasticity index R after testing 1 week, 2 weeks, 3 weeks, 4 weeks respectively2、R5、R7
Value (it is 450mbar that negative pressure is constant in test process).
Index explanation：Skin elasticity index R2、R5、R7Closer to 1, the elasticity of skin is better.
R2=Ua/Uf；R5=Ur/Ue；R7=Ur/Uf；
Uf--- skin maximum tension amount；
Ue--- after constant negative pressure is added on skin, the amount of tension of skin, positioning elastic part amount of tension at 0.1 second；
Ur--- after cancelling negative pressure, skin will restore to the original state rapidly state, equally be divided into elastic portion score value Ur, that is, cancel negative
Pressure is after 0.1 second, the recovery value and visco-elastic portions value or plastic value of skin；
Ua--- from cancellation negative pressure to the recovery value of skin when follow-on test skin surface adds negative pressure again next time.
Test result：
13 skin elasticity test result of table
As shown in Table 13：Volunteer is using after composite skin care product 4 weeks of embodiment 5 and embodiment 6, skin elasticity index
Rising is the most obvious, and skin elasticity has very big promotion, illustrates that the present invention wraps up beauty by multiple phospholipid bilayer
White nti-freckle ingredient, can not only promote the osmotic absorption of whitening spot-removing ingredient, additionally aid Sodium Hyaluronate, hydrolytic collagen and oil
The osmotic absorption of rouge increases skin elasticity and water content of stratum corneum.
The above embodiment is a preferred embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment
Limitation, other any changes, modifications, substitutions, combinations, simplifications made without departing from the spirit and principles of the present invention,
It should be equivalent substitute mode, be included within the scope of the present invention.
Claims (10)
1. a kind of lipoid plastid with whitening spot-removing function, it is characterised in that：Its with multilayer phospholipid bilayer, specifically by
The raw material of following weight percent is made：
Compound whitening spot-removing ingredient：10%~40%；
Soybean lecithin：10%~25%；
Sodium Hyaluronate：0.1%~5%；
Hydrolytic collagen：0.1%~5%；
Grease：0.1%~5%；
Water：Surplus.
2. the lipoid plastid according to claim 1 with whitening spot-removing function, it is characterised in that：The phospholipid bilayer
Layer has 12~24 layers.
3. the lipoid plastid according to claim 1 or 2 with whitening spot-removing function, it is characterised in that：The lipoids
The partial size of body is 500~1000nm.
4. the lipoid plastid according to claim 1 or 2 with whitening spot-removing function, it is characterised in that：The compounding beauty
White nti-freckle ingredient is extracted by deoxyarbutin, niacinamide, vitamin C, water-soluble fullerene, glycyrrhiza glabra extract, Mulberry Roots
Object and rice tunning compound.
5. the lipoid plastid according to claim 4 with whitening spot-removing function, it is characterised in that：The water solubility fowler
Alkene is surface through the processed fullerene of polyvinyl pyrrolidone modified.
6. the lipoid plastid according to claim 1 or 2 with whitening spot-removing function, it is characterised in that：The hyalomitome
Sour sodium is the digestion oligomerization Sodium Hyaluronate that molecular weight is less than 10000Da.
7. the lipoid plastid according to claim 1 or 2 with whitening spot-removing function, it is characterised in that：The grease by
Ceramide, tocopherol acetate, saualane, cod-liver oil and jojoba oil compound.
8. the preparation method of the lipoid plastid described in any one of claim 1~7 with whitening spot-removing function, feature
It is：Include the following steps：
1) Sodium Hyaluronate, hydrolytic collagen and water are uniformly mixed at 60~70 DEG C, obtain buffer solution；
2) a part of buffer solution is taken, compounding whitening spot-removing ingredient is added, is uniformly mixed at 40~50 DEG C, obtains content liquid；
3) soybean lecithin and grease are uniformly mixed, then evaporated under reduced pressure at 40~50 DEG C, obtain phospholipid membrane；
4) a part of phospholipid membrane is taken, content liquid is added, obtains the lipoid of single layer package using supercritical fluid reverse evaporation
Plastid；
5) lipoid plastid for taking a part of buffer solution dispersion single layer package, is added a part of phospholipid membrane, is squeezed using film
Platen press obtains the lipoid plastid of double wrapped, repeats the operation, obtains the lipoid plastid of multilayer package, then super with doughnut
Filter membrane is filtered for multiple times, and is removed partial size and is less than 500nm and the lipoid plastid greater than 1000nm, obtains having the function of whitening spot-removing
Lipoid plastid.
9. a kind of composite skin care product with whitening spot-removing function, it is characterised in that：By the raw material system of following weight percent
At：
The lipoid plastid of claim 1~7：15%~25%；
Glycerol：2%~7%；
Butanediol：2%~6%；
Glycine betaine：2%~4%；
Purslane extract：0.1%~0.3%；
Carbomer：0.1%~0.3%；
Arginine：0.1%~0.3%；
Gorgonian extract：0.1%~0.3%；
Panthenol：0.3%~0.7%；
Hexylene glycol：0.3%~0.7%；
Pungent glycol：0.3%~0.7%；
Phenoxyethanol：0.4%~0.7%；
Water：Surplus.
10. a kind of composite skin care product with whitening spot-removing function, it is characterised in that：By the raw material system of following weight percent
At：
A phase：
Glycerol：4%~6%；
Butanediol：2%~4%；
Glycerin polyether -26：2%~4%；
Carbomer：0.1%~0.3%；
Water：Surplus；
B phase：
Cocoyl glucoside：0.3%~0.7%；
Stearine：0.3%~0.7%；
Cetostearyl alcohol：0.3%~0.7%；
Ethylhexyl palmitate：2%~6%；
Caprylic/capric triglyceride：2%~4%；
Butyrospermum parkii fruit rouge：0.5%~1.5%；
C phase：
Panthenol：0.3%~0.7%；
Purslane extract：0.1%~0.2%；
Arginine：0.1%~0.2%；
Hexylene glycol：0.3%~0.7%；
Pungent glycol：0.3%~0.7%；
Phenoxyethanol：0.4%~0.7%；
Gorgonian extract：0.3%~0.7%；
The lipoid plastid of claim 1~7：15%~20%.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109481321A (en) * | 2018-12-17 | 2019-03-19 | 广州市晨茜化工有限公司 | A kind of Trenaxmine flexible lipidosome of whitening spot-removing and its preparation method and application |
| CN110151646A (en) * | 2019-05-13 | 2019-08-23 | 广州丽彦妆生物科技有限公司 | A kind of edible surface film liquid and preparation method thereof |
| CN110339085A (en) * | 2019-02-20 | 2019-10-18 | 广东芭薇生物科技股份有限公司 | A kind of composition and its application containing ceramide liposome |
| CN112891270A (en) * | 2021-01-29 | 2021-06-04 | 洪怡 | Cosmetic composition and preparation method and application thereof |
| CN113440450A (en) * | 2021-07-15 | 2021-09-28 | 广东雷诺化妆品研究院有限公司 | Whitening composition containing fullerene and preparation method and application thereof |
| CN114588054A (en) * | 2022-03-11 | 2022-06-07 | 广东丸美生物技术股份有限公司 | Whitening and moisturizing composition and preparation method and application thereof |
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1408338A (en) * | 2001-09-28 | 2003-04-09 | 上海知菲化妆品有限公司 | Liposome beauty cosmetic and its producing method |
| CN103432009A (en) * | 2013-09-12 | 2013-12-11 | 广东轻工职业技术学院 | Whitening agent liposome coating micro-capsule composition as well as preparation method and application thereof |
| CN103932908A (en) * | 2014-04-25 | 2014-07-23 | 北京博辉瑞进生物科技有限公司 | Composition for face whitening and preparation method thereof |
| CN107405282A (en) * | 2015-03-02 | 2017-11-28 | 株式会社爱茉莉太平洋 | Nanometer multilayer liposome containing skin lipid composition and preparation method thereof |
| CN107970131A (en) * | 2018-01-12 | 2018-05-01 | 连云港本草美汇医药科技有限公司 | A kind of whitening spot-removing liposome and its preparation method and application |
| CN108113899A (en) * | 2018-02-24 | 2018-06-05 | 广州市茗妍化妆品有限公司 | A kind of skin whitener and preparation method thereof |
| CN108210356A (en) * | 2017-12-29 | 2018-06-29 | 上海乐宝日化股份有限公司 | A kind of whitening emulsion and preparation method thereof |
-
2018
- 2018-08-30 CN CN201811005830.8A patent/CN108836882B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1408338A (en) * | 2001-09-28 | 2003-04-09 | 上海知菲化妆品有限公司 | Liposome beauty cosmetic and its producing method |
| CN103432009A (en) * | 2013-09-12 | 2013-12-11 | 广东轻工职业技术学院 | Whitening agent liposome coating micro-capsule composition as well as preparation method and application thereof |
| CN103932908A (en) * | 2014-04-25 | 2014-07-23 | 北京博辉瑞进生物科技有限公司 | Composition for face whitening and preparation method thereof |
| CN107405282A (en) * | 2015-03-02 | 2017-11-28 | 株式会社爱茉莉太平洋 | Nanometer multilayer liposome containing skin lipid composition and preparation method thereof |
| CN108210356A (en) * | 2017-12-29 | 2018-06-29 | 上海乐宝日化股份有限公司 | A kind of whitening emulsion and preparation method thereof |
| CN107970131A (en) * | 2018-01-12 | 2018-05-01 | 连云港本草美汇医药科技有限公司 | A kind of whitening spot-removing liposome and its preparation method and application |
| CN108113899A (en) * | 2018-02-24 | 2018-06-05 | 广州市茗妍化妆品有限公司 | A kind of skin whitener and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 方亮: "《药剂学》", 31 March 2016 * |
| 谢成等: "《纳米医药应用》", 31 October 2005, 海南出版社 * |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109481321A (en) * | 2018-12-17 | 2019-03-19 | 广州市晨茜化工有限公司 | A kind of Trenaxmine flexible lipidosome of whitening spot-removing and its preparation method and application |
| CN110339085A (en) * | 2019-02-20 | 2019-10-18 | 广东芭薇生物科技股份有限公司 | A kind of composition and its application containing ceramide liposome |
| CN110151646A (en) * | 2019-05-13 | 2019-08-23 | 广州丽彦妆生物科技有限公司 | A kind of edible surface film liquid and preparation method thereof |
| CN112891270A (en) * | 2021-01-29 | 2021-06-04 | 洪怡 | Cosmetic composition and preparation method and application thereof |
| CN113440450A (en) * | 2021-07-15 | 2021-09-28 | 广东雷诺化妆品研究院有限公司 | Whitening composition containing fullerene and preparation method and application thereof |
| CN114588054A (en) * | 2022-03-11 | 2022-06-07 | 广东丸美生物技术股份有限公司 | Whitening and moisturizing composition and preparation method and application thereof |
| CN114588054B (en) * | 2022-03-11 | 2023-11-21 | 广东丸美生物技术股份有限公司 | Whitening and moisturizing composition and preparation method and application thereof |
| CN116139036A (en) * | 2022-12-17 | 2023-05-23 | 上海优康化妆品有限公司 | Vitamin C-containing coated particles, preparation method thereof and vitamin C-containing essence |
| CN116139036B (en) * | 2022-12-17 | 2024-02-27 | 上海优康化妆品有限公司 | Vitamin C-containing coated particles, preparation method thereof and vitamin C-containing essence |
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Denomination of invention: Liposome-like and skincare composition with whitening and freckle-removing function Effective date of registration: 20230222 Granted publication date: 20210323 Pledgee: China Co. truction Bank Corp Guangzhou green finance reform and innovation pilot area Huadu Branch Pledgor: GUANGZHOU MEICHI COSMETICS Co.,Ltd. Registration number: Y2023980033167 |
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