CN103432009A - Whitening agent liposome coating micro-capsule composition as well as preparation method and application thereof - Google Patents
Whitening agent liposome coating micro-capsule composition as well as preparation method and application thereof Download PDFInfo
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- CN103432009A CN103432009A CN2013104144074A CN201310414407A CN103432009A CN 103432009 A CN103432009 A CN 103432009A CN 2013104144074 A CN2013104144074 A CN 2013104144074A CN 201310414407 A CN201310414407 A CN 201310414407A CN 103432009 A CN103432009 A CN 103432009A
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Abstract
The invention discloses a whitening agent liposome coating micro-capsule composition as well as a preparation method and an application thereof. The whitening agent liposome coating micro-capsule composition comprises 5-30% of whitening agent, 2-50% of polyhydric alcohol, 1-30% of phospholipids, 1-30% of grease, 1-10% of emulsifying agent and 1-30% of deionized water, wherein the whitening agent is coated by lecithin which is very similar to a skin lipid structure and is prone to penetrating into the deep layer of skin, thus the defect that the whitening agent is unlikely to be absorbed by the skin is overcome; the whitening agent coated by lecithin is isolated from oxygen in air, thus the detect that the whitening agent is prone to being oxidized and discoloring is solved; when whitening products containing the whitening agent liposome coating micro-capsule composition are used, the whitening agent is slowly released and has a long-time whitening effect.
Description
Technical field
The present invention relates to a kind of whitening agent liposomal microcapsule composition, be specifically related to a kind of whitening agent liposomal microcapsule composition and its preparation method and application.
Background technology
The color of human body skin depends mainly on melanic content and distribution situation in skin.Melanin is produced by the melanocyte that is present in stratum basale, the adjusting of nerve-endocrine factor and the impact of external environment condition in its metabolism receptor.While as skin, being subject to the external ultraviolet radiation irradiation, can activate the tryrosinase in skin, accelerate melanic generation, tanned and mottle reaction occur.The effect of the whitening active component in skin-lightening cosmetic is to stop melanic biosynthesis, or by human activin epidermis and hypodermal cell antiradical activities, promote the metabolic turnover of tegumentary chromatophore, reduce pigmentation degree and the excessive keratinization of epidermis, make Skin Cell high resilience and gloss.
Whitening composition mainly contains in the market: arbutin, vitamin C, kojic acid, ferulic acid etc.These whitening agents all have good whitening effect, but these whitening agents all exist easily by dioxygen oxidation in air, variable color and difficulty such as are absorbed by the skin at the defect, as being unfavorable for skin, vitamin C absorbs, and the very easily oxidation stain and lose whitening effect of heat, light time.
Summary of the invention
The problem existed in order to solve existing whitening composition, the performance such as the object of the invention is to provide a kind of whitening agent liposomal microcapsule composition, and said composition has stimulates little, stable in properties, easily be absorbed by the skin, whitening effect is good.
Another object of the present invention be by above-mentioned whitening agent liposomal microcapsule composition for skin-lightening cosmetic, make that zest is little, stable in properties, respond well skin-lightening cosmetic.
For realizing the first purpose of the present invention, the present invention has adopted following technical scheme: a kind of whitening agent liposomal microcapsule composition is characterized in that the component that comprises following percentage by weight:
Whitening agent 5-30%;
Polyhydric alcohol 2-50%;
Phosphatidase 11-30%;
Oils and fats 1-30%;
Emulsifying agent 1-10%;
Deionized water 1-40%.
Described whitening agent is one or both and the above mixture in arbutin, vitamin C, kojic acid, ferulic acid, glabridin, phenethanol resorcinol, nicotiamide.
Described polyhydric alcohol is one or both and the above mixture in glycerol, 1,2-PD, 1,3 butylene glycol.
Described phospholipid is one or both mixture in soybean lecithin, Ovum Gallus domesticus Flavus lecithin.
Described oils and fats is one or both and the above mixture in caprylic/capric triglyceride, C12-15 alcohol benzoate, tocopherol acetas, isopropyl palmitate, Oleum Camelliae, Fructus Maydis oil.
Described emulsifying agent is one or both and the above mixture in cetyl polyethylene/polypropylene glycol-10/1 polydimethylsiloxane, methyl glucose sesquistearate, glyceryl monostearate, iso stearic acid of glycerine ester, glyceryl oleate.
A kind of manufacture method of whitening agent liposomal microcapsule composition comprises the following steps:
(1) whitening agent, polyhydric alcohol, water are mixed, even 60-80 ℃ of lower stirring and dissolving, be water.
(2) oils and fats, phospholipid, emulsifying agent are mixed, even 60-80 ℃ of lower stirring and dissolving, be oil phase.
(3) water is mixed with oil phase, after stirring, process by high pressure homogenizer, high pressure homogenize pressure is 80-150MPa, and cycle-index is 1-10 time, obtains whitening agent liposomal microcapsule composition of the present invention.
For realizing the second purpose of the present invention, the present invention has adopted following technical scheme: the application by above-mentioned whitening agent liposomal microcapsule composition in the preparation skin-lightening cosmetic, it is characterized in that in skin-lightening cosmetic containing above-mentioned whitening agent liposomal microcapsule composition, its consumption is 0.1-40%, and preferable amount is 5-20%.Except containing above-mentioned whitening agent liposomal microcapsule composition, can suitably add as required and be applicable to the common composition that skin-lightening cosmetic is used, as matrix components such as wetting agent, emollient, water, emulsifying agents.
The dosage form of skin-lightening cosmetic is not particularly limited, and can be solution, emulsion, cream frost shape, spray etc.
The invention has the beneficial effects as follows: whitening agent is coated by lecithin, and lecithin is very similar to the skin lipid structure, is easy to the deep layer that penetrates to the skin, thereby overcomes the defect that whitening agent is difficult to be absorbed by the skin; In whitening agent after being coated by lecithin and air, oxygen is isolated, thereby has overcome the defect of the easy oxidized variable colors of these whitening agents; During the whitening product that contains whitening agent liposomal microcapsule composition of the present invention in use, whitening agent slowly discharges, and can keep long-time white-skinned face function.
The specific embodiment
Below come by specific embodiment that the present invention is further illustrated, but these embodiment are not limitations of the present invention just in order to illustrate.
the preparation of embodiment 1 whitening agent liposomal microcapsule composition (I)
(1) by 5% vitamin C, 8% ferulic acid, 5% glabridin, 10%1,2-propylene glycol, 8%1,3-butanediol, 31% deionized water mix, even 60-80 ℃ of lower stirring and dissolving, are water.
(2) 15% isopropyl palmitate, 10% caprylic/capric triglyceride, 6% soybean lecithin, 2% glyceryl monostearate are mixed, even 60-80 ℃ of lower stirring and dissolving, be oil phase.
(3) water is mixed with oil phase, after stirring, process by high pressure homogenizer, high pressure homogenize pressure is 90MPa, and cycle-index is 4 times, obtains whitening agent liposomal microcapsule composition of the present invention (I).
the preparation of embodiment 2 whitening agent liposomal microcapsule compositions (II)
(1), by 6% kojic acid, 6% arbutin, 4% nicotiamide, 15% glycerol, 6%1,3-butanediol, 30% deionized water mix, even 60-80 ℃ of lower stirring and dissolving, are water.
(2) 6% tocopherol acetas, 12% caprylic/capric triglyceride, 8% Oleum Camelliae, 4% soybean lecithin, 3% methyl glucose sesquistearate are mixed, even 60-80 ℃ of lower stirring and dissolving, be oil phase.
(3) water is mixed with oil phase, after stirring, process by high pressure homogenizer, high pressure homogenize pressure is 100MPa, and cycle-index is 3 times, obtains whitening agent liposomal microcapsule composition of the present invention (II).
The preparation of embodiment 3 whitening and skin-protecting breasts
Table 1 provides the whitening and skin-protecting breast formula that contains whitening agent liposomal microcapsule composition, and the consumption of each material means with mass fraction.
Table 1
The preparation method of whitening and skin-protecting breast: the dimethyl siloxane in formula table, isopropyl palmitate, caprylic/capric glyceride, monoglyceride, glyceryl oleate citrate, methyl hydroxybenzoate, propylparaben are mixed, be heated to 80 ℃, fusing stirs, as oil phase; 1,3 butylene glycol in formula table, deionized water are mixed, be heated to 85 ℃, stirring and dissolving is even, as water.Oil phase and water are added in the emulsifying pot, stir, add whitening agent liposomal microcapsule composition, emulsifying homogeneous, after 10 minutes, stirs while being cooled to 50 ℃, adds essence, stirs, and is cooled to 38 ℃, is the whitening and skin-protecting breast.
the preparation of the common whitening and skin-protecting breast of Comparative Examples 1
Table 2 provides common whitening and skin-protecting breast formula, and the consumption of each material means with mass fraction.
Table 2
The preparation method of whitening and skin-protecting breast: the dimethyl siloxane in formula table, isopropyl palmitate, caprylic/capric glyceride, monoglyceride, glyceryl oleate citrate, methyl hydroxybenzoate, propylparaben are mixed, be heated to 80 ℃, fusing stirs, as oil phase; 1,3 butylene glycol in formula table, vitamin C, ferulic acid, glabridin, deionized water are mixed, be heated to 85 ℃, stirring and dissolving is even, as water.Oil phase and water are added in the emulsifying pot, stir, emulsifying homogeneous, after 10 minutes, stirs while being cooled to 50 ℃, adds essence, stirs, and is cooled to 38 ℃, is the whitening and skin-protecting breast.
embodiment 4 heat-resistant stability evaluations
By the whitening and skin-protecting that the contains whitening agent liposomal microcapsule composition breast of embodiment 3 preparations and the common whitening and skin-protecting breast of Comparative Examples 1 preparation, be placed on respectively in transparent plastic bottle, be placed in 48 ℃ of calorstats, the outward appearance of every 3 days, observing primary production.Found that: the common whitening and skin-protecting breast of Comparative Examples 1 preparation is in the time of 5 days, and product color starts to become micro-yellow by white, and along with the passage of time color is deepened gradually; And the whitening and skin-protecting breast Continuous Observation of embodiment 3 preparation 20 days, the color and luster of product still keeps white, the phenomenon of color change do not occur.This explanation, after liposomal, the whitening agent microcapsule is better than the heat-resistant stability of the whitening agent that does not have to coat.
embodiment 5 light fastness stability evaluations
By the whitening and skin-protecting that the contains whitening agent liposomal microcapsule composition breast of embodiment 3 preparation and the common whitening and skin-protecting breast of Comparative Examples 1 preparation, be placed on respectively in transparent plastic bottle, be placed in the sunlight place of being exposed to the sun, every the outward appearance of 1 day observation primary production.Found that: the common whitening and skin-protecting breast of Comparative Examples 1 preparation is in the time of 2 days, and product color starts to become micro-yellow by white, and along with the passage of time color is deepened gradually; And the whitening and skin-protecting breast Continuous Observation of embodiment 3 preparation is in the time of 18 days, product color starts to become micro-yellow by white.This explanation, after liposomal, the whitening agent microcapsule is better than the light fastness stability of the whitening agent that does not have to coat.
Claims (3)
1. a whitening agent liposomal microcapsule composition, is characterized in that the component that comprises following percentage by weight: whitening agent 5-30%, polyhydric alcohol 2-50%, phosphatidase 11-30%, oils and fats 1-30%, emulsifying agent 1-10%, deionized water 1-40%; Described whitening agent is one or both and the above mixture in arbutin, vitamin C, kojic acid, ferulic acid, glabridin, phenethanol resorcinol, nicotiamide; Described polyhydric alcohol is one or both and the above mixture in glycerol, 1,2-PD, 1,3 butylene glycol; Described phospholipid is one or both mixture in soybean lecithin, Ovum Gallus domesticus Flavus lecithin; Described oils and fats is one or both and the above mixture in caprylic/capric triglyceride, C12-15 alcohol benzoate, tocopherol acetas, isopropyl palmitate, Oleum Camelliae, Fructus Maydis oil; Described emulsifying agent is one or both and the above mixture in cetyl polyethylene/polypropylene glycol-10/1 polydimethylsiloxane, methyl glucose sesquistearate, glyceryl monostearate, iso stearic acid of glycerine ester, glyceryl oleate.
2. the preparation method of a kind of whitening agent liposomal microcapsule composition claimed in claim 1 is characterized in that comprising the following steps:
(1) whitening agent, polyhydric alcohol, water are mixed, even 60-80 ℃ of lower stirring and dissolving, be water;
(2) oils and fats, phospholipid, emulsifying agent are mixed, even 60-80 ℃ of lower stirring and dissolving, be oil phase;
(3) water is mixed with oil phase, after stirring, process by high pressure homogenizer, high pressure homogenize pressure is 80-150MPa, and cycle-index is 1-10 time, obtains whitening agent liposomal microcapsule composition of the present invention.
3. the application of whitening agent liposomal microcapsule composition claimed in claim 1 in the preparation skin-lightening cosmetic, is characterized in that in skin-lightening cosmetic containing above-mentioned whitening agent liposomal microcapsule composition, and its consumption is 0.1-40%, and preferable amount is 5-20%.
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