CN108815314A - A kind of Chinese medicine preparation for treating duckling infection salmonella enteritidis - Google Patents
A kind of Chinese medicine preparation for treating duckling infection salmonella enteritidis Download PDFInfo
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- CN108815314A CN108815314A CN201810978019.1A CN201810978019A CN108815314A CN 108815314 A CN108815314 A CN 108815314A CN 201810978019 A CN201810978019 A CN 201810978019A CN 108815314 A CN108815314 A CN 108815314A
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/85—Verbenaceae (Verbena family)
- A61K36/855—Clerodendrum, e.g. glorybower
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Abstract
The invention discloses a kind of Chinese medicine preparation for treating duckling infection salmonella enteritidis, proportion is by weight:10~20 parts of granatum, 1~5 part of scutellaria, 5~10 parts of kuh-seng, 12~20 parts of folium isatidis, 5~8 parts of folium artemisiae argyi, 8~15 parts of myrobalan, 10~20 parts of the Chinese bulbul, 1~2 part of Radix Glycyrrhizae.The Chinese medicine preparation for the treatment of duckling infection salmonella enteritidis disclosed by the invention, medical fluid made from it is after drink-service, SOD activity in duckling liver can be made to significantly decrease during the administration, and MDA content is in the significant raising for the treatment of early stage, stage is substantially reduced, the results showed that the antibacterial action of Chinese herbal compound preparation and side effect is lower.
Description
Technical field
The present invention relates to animal doctor's technical field of traditional Chinese medicine preparation, in particular to a kind of to treat duckling infection salmonella enteritidis
Chinese medicine preparation.
Background technique
Fowl salmonellosis is a kind of global poultry diease, is of great significance in public health, it has been found that sramana
There are about 2213 serotypes for family name bacillus, but in different countries and regions, the predominant serotype for causing the disease often has certain difference
Not, there is its particularity.40%~80% is drawn by fowl Salmonella in the food poisoning that the developed countries such as Japan and the United States occur
It rises, wherein main pathogen is salmonella enteritidis.All the time, people are mostly from cause of disease, lesion characteristics, clinical symptoms and prevention and treatment
Method etc. is studied, there is not yet inquiring into drug Florfenicol or Chinese herbal compound preparation treatment to infection duckling liver
The influence of anti-oxidation function.
Summary of the invention
The Chinese medicine preparation for the treatment of duckling infection salmonella enteritidis provided by the invention, infected duckling are taking this
After medical fluid made of Chinese medicine preparation, superoxide dismutase (SOD) is able to maintain puts down compared with bottom water, and lipid peroxidation product
(MDA) first increasing in a short time then reduces, and shows that the Chinese medicine preparation curative effect is good and toxic side effect is lower.
The invention discloses a kind of Chinese medicine preparations for treating duckling infection salmonella enteritidis, and proportion is by weight
For:10~20 parts of granatum, 1~5 part of scutellaria, 5~10 parts of kuh-seng, 12~20 parts of folium isatidis, 5~8 parts of folium artemisiae argyi, myrobalan 8~15
Part, 10~20 parts of the Chinese bulbul, 1~2 part of Radix Glycyrrhizae.
It by above-mentioned Chinese medicine preparation, is decocted medicinal herbs with the 15 of raw material gross weight extraordinarily water, wherein Radix Glycyrrhizae is to be decocted first, after granatum is
Under, boil with strong fire moderate heat after water and boil 1~2 hour, it is rear under when be adjusted to intense fire again and kept for 10 minutes, filter residue.Medical fluid obtained
By 1:10 mix with clear water and freely drink for duckling.
It is disclosed by the invention treatment duckling infection salmonella enteritidis Chinese medicine preparation, made from medical fluid in drink-service
Afterwards, SOD activity in duckling liver can be made to significantly decrease during the administration, and MDA content is significantly increased in treatment early stage,
Stage is substantially reduced, the results showed that the antibacterial action of Chinese herbal compound preparation and side effect is lower.
Specific embodiment
It is carried out below with reference to technical effect of the embodiment to design of the invention, specific structure and generation clear, complete
Ground description, to be completely understood by the purpose of the present invention, feature and effect.Obviously, described embodiment is of the invention one
Section Example, rather than whole embodiments, the embodiment of the present invention, those skilled in the art are not making the creative labor
Under the premise of other embodiments obtained, belong to the scope of protection of the invention.In addition, all connections being previously mentioned in text/
Connection relationship not singly refers to that component directly connects, and referring to can be auxiliary by adding or reducing connection according to specific implementation situation
Part, to form more preferably coupling structure.Each technical characteristic in the invention, can under the premise of not conflicting conflict
With combination of interactions.
Embodiment 1, Chinese medicine preparation No.1, by 15 parts of granatum, 3 parts of scutellaria, 7 parts of kuh-seng, 16 parts of folium isatidis, 6 parts of folium artemisiae argyi,
11 parts of myrobalan, 15 parts of the Chinese bulbul, 1 part of preparation raw material of Radix Glycyrrhizae and clean drain, decocted medicinal herbs with the 15 of raw material gross weight extraordinarily water, wherein
Radix Glycyrrhizae is to be decocted first, granatum be after under, boil with strong fire moderate heat after water and boil 1.5 hours, it is rear under when be adjusted to intense fire again and keep 10
Minute, filter residue, by 1:10 are mixed into No.1 medical fluid with clear water.
Embodiment 2, Chinese medicine preparation two, by 10 parts of granatum, 5 parts of scutellaria, 5 parts of kuh-seng, 20 parts of folium isatidis, 5 parts of folium artemisiae argyi,
8 parts of myrobalan, 10 parts of the Chinese bulbul, 2 parts of preparation raw materials of Radix Glycyrrhizae and clean drain, decocted medicinal herbs with the 15 of raw material gross weight extraordinarily water, wherein
Radix Glycyrrhizae is to be decocted first, granatum be after under, boil with strong fire moderate heat after water and boil 2 hours, it is rear under when be adjusted to intense fire again and kept for 10 points
Clock, filter residue, by 1:10 are mixed into No. two medical fluids with clear water.
Embodiment 3, Chinese medicine preparation three, by 20 parts of granatum, 1 part of scutellaria, 9 parts of kuh-seng, 13 parts of folium isatidis, 8 parts of folium artemisiae argyi,
15 parts of myrobalan, 20 parts of the Chinese bulbul, 1 part of preparation raw material of Radix Glycyrrhizae and clean drain, decocted medicinal herbs with the 15 of raw material gross weight extraordinarily water, wherein
Radix Glycyrrhizae is to be decocted first, granatum be after under, boil with strong fire moderate heat after water and boil 1 hour, it is rear under when be adjusted to intense fire again and kept for 10 points
Clock, filter residue, by 1:10 are mixed into No. three medical fluids with clear water.
Embodiment 4, contrast verification.
The duckling for taking same batch hatching breeding is randomly divided into healthy control group (1. group), western medicine group (2. group), No.1
Liquid medicine applying group (3. group), No. two liquid medicine applying groups (4. group) and No. three liquid medicine applying groups (5. group).It is right in addition to healthy control group
All ducklings with chest muscle inject artificial challenge's salmonella enteritidis, dosage be 500,000,000/only.Infection starts continuous drinking water administration 4
It, 12 hours, 36 hours, 60 hours and 84 hours each groups compel to kill 4 ducklings and acquire liver organization to be used to prepare enzyme after administration
Liquid.
Pass through artificial challenge's salmonella enteritidis, the results showed that, duckling liver SOD activity increased before infecting 36h and
It is reduced after 60h, and MDA content then increases before 12h, then declines, and illustrates that hepatic antioxidative function is obtained in the infection later period
It significantly improves.Meanwhile the duckling of artificial challenge's salmonella enteritidis is carried out with Western medicine Florfenicol and compound Chinese medicinal preparation
Drinking water administration treatment, can enhance the anti-oxidation function of liver, and the effect of Western medicine Florfenicol as the result is shown to a certain extent
Rapidly and the effect of Chinese herbal compound preparation is slow, but from lipid peroxidation product MDA containing taking temperature, the pair of Chinese herbal compound preparation
It acts on smaller.
Better embodiment of the invention is illustrated above, but the invention is not limited to the implementation
Example, those skilled in the art can also make various equivalent modifications on the premise of without prejudice to spirit of the invention or replace
It changes, these equivalent variation or replacement are all included in the scope defined by the claims of the present application.
Claims (5)
1. a kind of Chinese medicine preparation for treating duckling infection salmonella enteritidis, it is characterised in that including granatum, scutellaria, hardship
Ginseng, folium isatidis, folium artemisiae argyi, myrobalan, the Chinese bulbul, Radix Glycyrrhizae.
2. the Chinese medicine preparation for the treatment of duckling infection salmonella enteritidis according to claim 1, which is characterized in that it is matched
Than being by weight:10~20 parts of granatum, 1~5 part of scutellaria, 5~10 parts of kuh-seng, 12~20 parts of folium isatidis, 5~8 parts of folium artemisiae argyi,
8~15 parts of myrobalan, 10~20 parts of the Chinese bulbul, 1~2 part of Radix Glycyrrhizae.
3. the Chinese medicine preparation for the treatment of duckling infection salmonella enteritidis according to claim 2, which is characterized in that it is matched
Than being by weight:15 parts of granatum, 3 parts of scutellaria, 7 parts of kuh-seng, 16 parts of folium isatidis, 6 parts of folium artemisiae argyi, 11 parts of myrobalan, the Chinese bulbul 15
Part, 1 part of Radix Glycyrrhizae.
4. the Chinese medicine preparation for the treatment of duckling infection salmonella enteritidis according to claim 2, which is characterized in that it is matched
Than being by weight:10 parts of granatum, 5 parts of scutellaria, 5 parts of kuh-seng, 20 parts of folium isatidis, 5 parts of folium artemisiae argyi, 8 parts of myrobalan, the Chinese bulbul 10
Part, 2 parts of Radix Glycyrrhizae.
5. the Chinese medicine preparation for the treatment of duckling infection salmonella enteritidis according to claim 2, which is characterized in that it is matched
Than being by weight:20 parts of granatum, 1 part of scutellaria, 9 parts of kuh-seng, 13 parts of folium isatidis, 8 parts of folium artemisiae argyi, 15 parts of myrobalan, the Chinese bulbul 20
Part, 1 part of Radix Glycyrrhizae.
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Citations (4)
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2018
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Patent Citations (4)
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CN103372075A (en) * | 2012-04-11 | 2013-10-30 | 广东省农业科学院畜牧研究所 | Traditional Chinese medicine superfine powder composition resistant to chicken colibacillosis and preparation method thereof |
CN102670762A (en) * | 2012-05-23 | 2012-09-19 | 天津生机集团股份有限公司 | Chinese medicinal composition for treating drug-resistant Salmonellosis avium, and preparation method thereof |
CN103272052A (en) * | 2013-05-31 | 2013-09-04 | 天津生机集团股份有限公司 | Traditional Chinese medicinal oral preparation for treating poultry salmonella infection and preparation method thereof |
CN103405536A (en) * | 2013-08-14 | 2013-11-27 | 北京元亨神农科技发展有限公司 | Chinese herbal veterinary drug used for treating diarrhoea and preparation method thereof |
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Title |
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