CN104840624A - Traditional Chinese medicine composition for treating rheumatoid arthritis and preparation method thereof - Google Patents

Abstract

The invention provides a traditional Chinese medicine composition for treating rheumatoid arthritis. The traditional Chinese medicine composition is prepared from the following active pharmaceutical ingredients in parts by weight: 18-20 parts of long stephania herb, 18-20 parts of root of tubeflower duchmans pipe, 25-28 parts of girardinia diversifolia, 25-28 parts of calyx-shaped daphniphyllum, 12-15 parts of papermulberry fruit, 10-12 parts of dried oviduct of Chinese forest frog, 12-15 parts of pleurotus citrinopileatus, 8-10 parts of seed of flax and 15-18 parts of grape seed oil. The traditional Chinese medicine composition has the beneficial effects that through compatibility of the medicines, the traditional Chinese medicine composition has the functions of dispelling wind and removing obstruction in the meridians, promoting qi circulation to relieve pain, dispelling wind and eliminating dampness and strengthening the body and preventing inflammation; the synergistic effects of the medicine components are very prominent; the traditional Chinese medicine composition has small side effects and has very obvious treatment effects on rheumatoid arthritis.

Description

A kind of Chinese medicine composition for the treatment of rheumatoid arthritis and preparation method thereof

Technical field

The invention belongs to field of medicaments, be specially a kind of Chinese medicine composition for the treatment of rheumatoid arthritis and preparation method thereof.

Background technology

Rheumatoid arthritis, also known as rheumatoid, is the chronic systemic inflammation disease that a kind of cause of disease not yet understands, for main clinical manifestation, belongs to autoimmune inflammatory disease with pathological changes outside chronic, symmetry, many synovial jointss inflammation and joint.This disease is apt to occur in the Minor articulus such as hands, wrist, foot, and recurrent exerbation, is symmetric.

It is the prerequisite of all rehabilitations that rheumatoid arthritis is treated, and for rheumatoid patient, application has the Chinese medicine of spleen invigorating, removing dampness, dredging collateral effect, to improve arthralgia, swelling, the symptom such as stiff.Meanwhile, can damp be dispelled, benefiting QI and nourishing blood, obviously strengthen patient's reticuloendothelial system phagocytic function, promote lymphocyte transformation and form active garland.Pain relieving Western medicine: can only pain relieving, can not control pain, long-term taking easily produces dependency and toxic and side effects, not only unhelpful but also stimulating intestine and stomach, damage Liver and kidney.Naturopathy: naturopathy comprises the methods such as electrotherapy, infrared ray radiation, thermotherapy, and all patients doing physical therapy know, can be more comfortable when doing physical therapy, again can be as before after not doing.Massage acupuncture: substantially identical with naturopathy object.Be exactly the clinical symptoms to alleviate patient, but not radical cure means.Operative treatment: because indication requires very strict, the features such as the crowd being applicable to clinically performing an operation, less than 5%, adds costly, and wound is large, and convalescent period is long, easy recurrence, so cannot popularize in an all-round way at all.

Summary of the invention

The object of this invention is to provide a kind of Chinese medicine composition for the treatment of rheumatoid arthritis and preparation method thereof.

The present invention treats the Chinese medicine composition of rheumatoid arthritis; Be made up of the crude drug of following parts by weight: 18 ~ 20 parts, mouldboard rattan, Radix aristolochiae tubiflorae 18 ~ 20 parts, stinging nettle 25 ~ 28 parts, Daphniphyllum calycinum 25 ~ 28 parts, Fructus Broussonetiae 12 ~ 15 parts, Oviductus Ranae 10 ~ 12 parts, Pleurotus citrinopileatus 12 ~ 15 parts, Semen Lini 8 ~ 10 parts, Oleum Vitis viniferae 15 ~ 18 parts.

As optimization, the Chinese medicine composition of this treatment rheumatoid arthritis, the crude drug by following parts by weight: 19 parts, mouldboard rattan, Radix aristolochiae tubiflorae 19 parts, stinging nettle 26 parts, Daphniphyllum calycinum 26 parts, Fructus Broussonetiae 13 parts, Oviductus Ranae 11 parts, Pleurotus citrinopileatus 13 parts, Semen Lini 9 parts, Oleum Vitis viniferae 16 parts.

Prepare the method for the Chinese medicine composition of this treatment rheumatoid arthritis, comprise the following steps:

A, by the mouldboard rattan of described parts by weight, Radix aristolochiae tubiflorae, stinging nettle, Daphniphyllum calycinum, Fructus Broussonetiae, Oviductus Ranae, Pleurotus citrinopileatus, Semen Lini pulverize after mixing, by solid-liquid ratio 1:9, add 70% ethanol, reflux, extract, 3 times, each 2 ~ 3 hours, merge backflow; Be condensed into the extractum that relative density is 1.25 ~ 1.32 (35 DEG C);

B, by the Oleum Vitis viniferae of described parts by weight with the extractum in step a, after mix homogeneously, load in soft capsule according to 0.48 gram one.

The present invention treats in the Chinese medicine composition prescription of rheumatoid arthritis, and mouldboard rattan is taken heat-clearing and toxic substances removing, dampness removing, detumescence, relieving constipation, dispelling wind and removing obstruction in the collateral orally, goes long-pending pain relieving; Cure mainly: diarrhoea, acute nephritis, bacillary dysentery, mastitis, carbuncle skin ulcer redness, rheumatic arthritis, sciatica, hernia, dysuria, finger skin ulcer, traumatic injury, dog bite.Radix aristolochiae tubiflorae heat-clearing and toxic substances removing; Promoting the circulation of QI to relieve pain; Main venom; Skin infection furuncle and phyma; Have a stomach-ache pain; Enteritis and dysentery; Diarrhoea; Fengshi Guanjie pain; Dysmenorrhea; Traumatic injury.Stinging nettle expelling wind and removing dampness, promoting blood circulation and stopping pain is antipruritic; Cure mainly rheumatic numbness, arthralgia, impairment caused by overstrain pain, colic, edema, venom, skin pruritus, infantile convulsion milk regurgitation, women's puerperal asthenia.Daphniphyllum calycinum heat-clearing and toxic substances removing, relaxing muscles and tendons to promote blood circulation; For cold, fever, tonsillitis, rheumatic arthritis; Treating swelling and pain by traumatic injury is controlled in external, fracture, venom, sore swollen toxin.Fructus Broussonetiae the kidney invigorating liver heat removing, improving eyesight, diuresis; For soreness of the waist and knees, asthenia hectic fever due to YIN-deficiency, dizzy blurred vision, the raw nebula film of order, edema distension.Pleurotus citrinopileatus has high medical value, containing polysaccharide body first in the mucus on its cap, can prevent the infection of grape grape coccus, escherichia coli, pneumobacillus and tubercule bacillus; Also containing a kind of nucleic acid in mucus, it is mental to human body, energy has restitution; Therefore, Pleurotus citrinopileatus has effect of anticancer, anti-inflammation, brain-strengthening, strong body.Semen Lini moisturizes laxation, nourishing the liver and kidney; For depletion of body fluid causing lack of blood, constipation, empty, the dizzy disease such as weak of body after being ill.Oviductus Ranae the kidney invigorating and essence nourishing, nourishing YIN and moistening the lung; Weak for the deficiency of YIN, spiritlessness and weakness, palpitation and insomnia, night sweat is more than, and consumptive disease is coughed hemoptysis.Semen Vitis viniferae free radical resisting, reduction blood fat, protection skin, protection brain, antiallergic, protection blood vessel, radioprotective, protective tissue, protection eyes; Effective ingredient procyanidin is high-efficiency antioxidant agent, is the most effective free radical scavenger, has very strong activity in vivo; The initiation potential of the diseases such as heart disease, cancer, senilism, arthritis can be reduced; Strengthen blood vessel wall resistance; Reduce the initiation potential of diabetes; Strengthen skin elasticity and smoothness, prevention sunray is to effects such as the radiation damagies of skin.

All medicine compatibilities above, have effect of dispelling wind and removing obstruction in the collateral, promoting the circulation of QI to relieve pain, expelling wind and removing dampness, the strong anti-inflammation of body; Each ingredient synergism is very outstanding, and side effect is little, and treatment rheumatoid arthritis effect is very remarkable.

Detailed description of the invention

The invention will be further described for embodiment plan given below; but can not be interpreted as it is limiting the scope of the invention; those skilled in the art to nonessential improvement and adjustment more of the present invention, still belong to protection scope of the present invention according to content of the present invention.

Embodiment 1, a, by 190 grams, mouldboard rattan, Radix aristolochiae tubiflorae 190 grams, stinging nettle 260 grams, Daphniphyllum calycinum 260 grams, Fructus Broussonetiae 130 grams, Oviductus Ranae 110 grams, Pleurotus citrinopileatus 130 grams, Semen Lini 90 grams pulverize after mixing, by solid-liquid ratio 1:9, add 70% ethanol, reflux, extract, 3 times, each 2 ~ 3 hours, merge backflow; Be condensed into the extractum that relative density is 1.25 ~ 1.32 (35 DEG C);

B, by Oleum Vitis viniferae 160 grams with the extractum in step a, after mix homogeneously, load in soft capsule according to 0.48 gram one.

Embodiment 2, a, by 180 grams, mouldboard rattan, Radix aristolochiae tubiflorae 180 grams, stinging nettle 250 grams, Daphniphyllum calycinum 250 grams, Fructus Broussonetiae 120 grams, Oviductus Ranae 100 grams, Pleurotus citrinopileatus 120 grams, Semen Lini 80 grams pulverize after mixing, by solid-liquid ratio 1:9, add 70% ethanol, reflux, extract, 3 times, each 2 ~ 3 hours, merge backflow; Be condensed into the extractum that relative density is 1.25 ~ 1.32 (35 DEG C);

B, by Oleum Vitis viniferae 150 grams with the extractum in step a, after mix homogeneously, load in soft capsule according to 0.48 gram one.

Embodiment 3, a, by 200 grams, mouldboard rattan, Radix aristolochiae tubiflorae 200 grams, stinging nettle 280 grams, Daphniphyllum calycinum 280 grams, Fructus Broussonetiae 150 grams, Oviductus Ranae 120 grams, Pleurotus citrinopileatus 150 grams, Semen Lini 100 grams pulverize after mixing, by solid-liquid ratio 1:9, add 70% ethanol, reflux, extract, 3 times, each 2 ~ 3 hours, merge backflow; Be condensed into the extractum that relative density is 1.25 ~ 1.32 (35 DEG C);

B, by Oleum Vitis viniferae 180 grams with the extractum in step a, after mix homogeneously, load in soft capsule according to 0.48 gram one.

Pertinent clinical data is as follows: physical data: patient with rheumatoid arthritis 338 example.Wherein male 137 example, women 201 example, 27 years old ~ 73 years old age, 47 years old mean age.The course of disease 3 months ~ 19 years, average course of disease 4.8 years.Be divided into 2 groups at random, often organize 169 examples.

Diagnosis basis: Western medicine diagnose was both diagnosed according to American Rheumatism Association's revision diagnosis of rheumatoid arthritis standard in 1987.Diagnostic criteria comprises: (1) deadlock in morning is 1h (course of disease >=6 week) at least; (2) 3 or 3 delete with upper joint; (3) wrist, metacarpophalangeal joints or near-end refer to ask swollen joint; (4) symmetry swollen joint; (5) subcutaneous nodule; (6) hands x line sheet changes; (7) rheumatoid factor positive (titre >1:32).All possess above 4 standards, and patient with connection portion symptom for main person examines as rheumatoid arthritis.

Tcm diagnosis is ridiculed according to the diagnosis basis of arthromyodynia in disease of tcm Standardization of diagnosis and curative effect and is diagnosed.Patients is joint swelling and pain, localized pain, and morning, stiff joint stuffiness, met then pain play of trembling with fear, and local fear of cold is afraid of cold, thin white fur of tongue, and floating and tense pulse or heavy tight person are diagnosed as wind-cold-damp retention type arthromyodynia.Door bolt.Possess above condition, and patient with knee symptom for main person examines as rheumatoid gonarthritis.Inclusive criteria: simultaneously meet Western medicine diagnose standard and tcm diagnosis standard.

Therapeutic Method: matched group, simple oral ZHENGQINGFENGTONGNING PIAN, each two, every day three times.Treatment group, adopts the capsule in the embodiment of the present invention, each three, every day three times, observe the curative effect after month.

Efficacy evaluation: efficacy evaluation is evaluated according to the efficacy assessment standard of arthromyodynia in disease of tcm Standardization of diagnosis and curative effect.(1) clinical cure: arthralgia, swelling disappear, and movable function is normal, and lab testing is normal; (2) take a turn for the better: arthralgia, swelling alleviate, movable function takes a turn for the better, and lab testing is improved; (3) do not heal: arthralgia, swelling and lab testing are unchanged.Two groups of patient's efficacy results are in table 1.

Claims (3)

1. treat the Chinese medicine composition of rheumatoid arthritis for one kind; It is characterized in that being made up of the crude drug of following parts by weight: 18 ~ 20 parts, mouldboard rattan, Radix aristolochiae tubiflorae 18 ~ 20 parts, stinging nettle 25 ~ 28 parts, Daphniphyllum calycinum 25 ~ 28 parts, Fructus Broussonetiae 12 ~ 15 parts, Oviductus Ranae 10 ~ 12 parts, Pleurotus citrinopileatus 12 ~ 15 parts, Semen Lini 8 ~ 10 parts, Oleum Vitis viniferae 15 ~ 18 parts.

2. the Chinese medicine composition for the treatment of rheumatoid arthritis according to claim 1, it is characterized in that by the crude drug of following parts by weight: 19 parts, mouldboard rattan, Radix aristolochiae tubiflorae 19 parts, stinging nettle 26 parts, Daphniphyllum calycinum 26 parts, Fructus Broussonetiae 13 parts, Oviductus Ranae 11 parts, Pleurotus citrinopileatus 13 parts, Semen Lini 9 parts, Oleum Vitis viniferae 16 parts.

3. prepare the method that power requires the Chinese medicine composition for the treatment of rheumatoid arthritis described in 1, it is characterized in that comprising the following steps:

A, by the mouldboard rattan of described parts by weight, Radix aristolochiae tubiflorae, stinging nettle, Daphniphyllum calycinum, Fructus Broussonetiae, Oviductus Ranae, Pleurotus citrinopileatus, Semen Lini pulverize after mixing, by solid-liquid ratio 1:9, add 70% ethanol, reflux, extract, 3 times, each 2 ~ 3 hours, merge backflow; Be condensed into the extractum that relative density is 1.25 ~ 1.32 (35 DEG C);

B, by the Oleum Vitis viniferae of described parts by weight with the extractum in step a, mix homogeneously loads in soft capsule.