CN106074785A - A kind of Chinese medicinal formulae treating cattle diarrhea due to damp-heat and preparation method thereof - Google Patents

A kind of Chinese medicinal formulae treating cattle diarrhea due to damp-heat and preparation method thereof Download PDF

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Publication number
CN106074785A
CN106074785A CN201610612165.3A CN201610612165A CN106074785A CN 106074785 A CN106074785 A CN 106074785A CN 201610612165 A CN201610612165 A CN 201610612165A CN 106074785 A CN106074785 A CN 106074785A
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China
Prior art keywords
damp
heat
preparation
diarrhea due
cattle
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Pending
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CN201610612165.3A
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Chinese (zh)
Inventor
魏彦明
胡俊杰
纪鹏
华永丽
姚万玲
张晓松
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Gansu Agricultural University
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Gansu Agricultural University
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Priority to CN201610612165.3A priority Critical patent/CN106074785A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/739Sanguisorba (burnet)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/235Foeniculum (fennel)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/53Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

A kind of herbal mixture treating cattle diarrhea due to damp-heat and preparation method thereof, it is provided that it is clinical dilute half congealed to rush down excrement that one treats cattle, and abnormal smells from the patient is smelt as of rotten fish, oliguria with yellow urine;Appetite, ruminate minimizing or useless absolutely, lassitude;Body heat is thirsty, mouth color reddish yellow, yellowish fur, and asoscope antiperspirant waits prescription and the preparation method of diarrhea due to damp-heat less.This pharmaceutical preparation is simple, and preparation is convenient, and clinical practice is safe efficient, cheap.

Description

A kind of Chinese medicinal formulae treating cattle diarrhea due to damp-heat and preparation method thereof
Technical field
The invention belongs to veterinary drug, relate generally to a kind of prescriptions of Chinese medicine treating cattle diarrhea due to damp-heat and preparation method thereof.
Background technology
In recent years, diarrhea due to damp-heat is a kind of common clinical in cattle-raising and frequently-occurring disease, and it is dilute half congealed that clinical card one's own judgment rushes down excrement, Abnormal smells from the patient is smelt as of rotten fish, oliguria with yellow urine;Other Symptoms are lassitude, appetite, ruminate minimizing or useless absolutely;Body heat is thirsty, and mouth color is red Huang, yellowish fur, the symptoms such as asoscope antiperspirant is few.Along with cattle intensive culture and the increase of mobility, cattle suffers from and diarrhea due to damp-heat The disease that card is relevant is notable ascendant trend, the acute chronic gastroenteritis on modern veterinary clinic, acute and chronic bacillary dysentery, infection Property gastroenteritis, the disease such as ulcerative colitis all may occur in which assertive evidence.This card damp pathogen being heavy and turbid in nature, viscous, damp be disease, the course of disease the most relatively Recurrent exerbation long, normal, very difficult healing.In cattle-raising, owing to pursuing economic interests simply on producing, cause abuse of antibiotics, Cause and make antibacterials decline evident in efficacy because drug resistance increases, cause tremendous economic to lose modern farming enterprise's aquaculture, and Owing to drug residue can produce toxic and side effects, serious harm human health.Chinese herbal medicine inherently natural plants, and be through Long-term clinical practice preserves.Its aboundresources, with a long history, have with food homology, consubstantiality, with feature, hold concurrently The nutritious dual function with medicine.Thus, the preparation developing safe and efficient preventing and treating cattle diarrhea due to damp-heat has preferable market Prospect.Four taste Chinese medicines in this prescription are both from natural plants, and price is low, and noresidue, has no side effect, and has no drug resistance. In vivo test shows, this medicine has good therapeutical effect to diarrhea due to damp-heat card rat, may be used for treating cattle diarrhea due to damp-heat card.
Summary of the invention
The cattle diarrhea due to damp-heat that it is an object of the invention to substitute antibiotics preventing and treating veterinary clinic common for developing Chinese medicine is demonstrate,proved.Should Chinese herb prevention cattle diarrhea due to damp-heat card will not produce toxic and side effects, in cattle body and products thereof in noresidue, cattle-raising can be promoted Develop in a healthy way, the products such as safe milk, meat are provided for human lives.
The present invention is achieved in that the feature according to veterinary clinic diarrhea due to damp-heat card, according to the dialectical opinion of traditional Chinese veterinary medicine Administer opinion, regulate the flow of vital energy with spleen invigorating, dampness of detoxifying, promoting blood circulation and stopping pain is principle, selects wide material sources, cheap Herba Erodii 40 g, Radix Sanguisorbae 40 g, Radix Glycyrrhizae 25 g, Fructus Foeniculi 30 g, totally 4 taste Chinese medicine.By water boiling and extraction active ingredient, go the removal of impurity, prepare water Decoct.
Water decoction preparation method is as follows: (1) weighs Herba Erodii 40 g in prescription, Radix Sanguisorbae 40 g, Radix Glycyrrhizae 25 g, Fructus Foeniculi Above-mentioned four taste Chinese medicines are mixed by 30 g;(2) first time adds water after 1300 mL soak 1 h and decocts, after intense fire boils, Slow fire boiling 1.5 h, filters, takes filtrate;Second time adds 1040 mL soak by water, after intense fire boils, and slow fire boiling 1 h, filter, Take filtrate;(3) decocting medicinal liquid by twice to merge, utilize 8 layers of filtered through gauze, filtrate is centrifuged 10 min with 3000 r/min, takes Clear liquid, abandons precipitation;(4) utilize Rotary Evaporators by supernatant concentration to 67.5 mL water decoctions;(5) to prepared decocting Agent packs, it is thus achieved that commodity Chinese medicine decoction.Preparing crude drug content is 2.0g/mL oral liquid.
The principle of this compound Chinese medicinal preparation: diarrhea due to damp-heat card be Niu Changjian disorder of gastrointestinal tract, its with stomachache of having loose bowels, rush down lower urgency Compel or rush down and not well, abnormal smells from the patient is stench, oliguria with yellow urine is main clinic symptoms.According to the dialectical argumentation theory of traditional Chinese veterinary medicine, prescription should Regulating the flow of vital energy with spleen invigorating, dampness of detoxifying, promoting blood circulation and stopping pain is principle.Among this prescription, Herba Erodii, Radix Sanguisorbae have relieving diarrhea with astringents effect, For ministerial drug;Fructus Foeniculi has effect of stomach invigorating, circulation of qi promoting, it is possible to be in harmonious proportion owing to Herba Erodii causes the card of taste discomfort, for adjuvant drug;Sweet Grass has the effect of coordinating the actions of various ingredients in a prescription, for making medicine.Four taste Chinese medicine combinations, have good therapeutic effect to cattle diarrhea due to damp-heat card.
The invention have the advantages that in (1) food, the chemical medicinal residue such as antibiotic is to endanger food safety at present, enters And one of principal element affecting human health, use Chinese medicine to substitute antibiotic therapy cattle diarrhea due to damp-heat card, cattle can be significantly reduced Antibiotic remains in derived food;(2) in cattle gastrointestinal disease is treated, abuse of antibiotics is easily generated Resistant strain, at milk, beef Remain Deng in product, serious threat human health, use Chinese medicine substitute antibiotics treatment cattle diarrhea due to damp-heat card, fastbacteria can be prevented The generation of strain and warrantor's antibiotic effective;(3) chemical medicinal residue such as antibiotic in the food such as milk, beef, people eats Easily cause allergic reaction with rear, threaten human health, use Chinese medicine to replace antibiotics that the residual caused allergy of medicine can be avoided anti- Should;(4) pharmacodynamics and clinical test results show, this Drug therapy cattle diarrhea due to damp-heat card is evident in efficacy, effective percentage 100%, cure Rate reaches more than 90%;(5) four taste Chinese medicines in we are the most cheap, easy popularization and application.
Detailed description of the invention
Below embodiment of the present invention is described in detail.
A kind of herbal mixture treating cattle diarrhea due to damp-heat card and preparation method thereof, its prescription is by Herba Erodii 40 g, Radix Sanguisorbae 40 G, Radix Glycyrrhizae 25 g, Fructus Foeniculi 30 g, four taste Chinese medicine compositions.
A kind of herbal mixture treating cattle diarrhea due to damp-heat and preparation method thereof is as follows: (1) weighs the Herba Erodii 40 in prescription Above-mentioned four taste Chinese medicines are mixed by g, Radix Sanguisorbae 40 g, Radix Glycyrrhizae 25 g, Fructus Foeniculi 30 g;(2) add water 1300 mL leachings for the first time Decoct after steeping 1 h, after intense fire boils, slow fire boiling 1.5 h, filters, takes filtrate;Second time adds 1040 mL soak by water, After intense fire boils, slow fire boiling 1 h, filters, takes filtrate;(3) decoct medicinal liquid by twice to merge, utilize 8 layers of filtered through gauze, filtrate It is centrifuged 10 min with 3000 r/min, takes supernatant, abandon precipitation;(4) utilize Rotary Evaporators by supernatant concentration to 67.5 ML, preparing crude drug content is 2.0 g/mL water decoctions;(5) prepared water decoction is packed, it is thus achieved that in commodity Liquid medicine decoct.
The range of application of this medicine: cattle diarrhea due to damp-heat card is had therapeutical effect is the most notable to calf effect especially.
The using method of this medicine: when being used for treating cattle diarrhea due to damp-heat, gavage crude drug content is that 2.0 g/mL are administered orally every time Liquid, by 0.5 mL/kg body weight, is used in conjunction 3-5 days and can cure.
Clinical efficacy: to cattle diarrhea due to damp-heat common to veterinary clinic, clinical manifestation have loose bowels stomachache, rush down lower urgent or rush down and Sick cattle not well, that abnormal smells from the patient stench, oliguria with yellow urine is main clinic symptoms, effective percentage 100%, cure rate reaches 90%;To calf large intestine Bacilus diarrhoea and mixed infection diarrhoea have good therapeutical effect, and effective percentage 100%, cure rate reaches 90%.
Toxicity or side effect: utilizing white mice to do acute toxicity and long term toxicity test, result shows: this herbal mixture mouth Take liquid and do not show any toxicity or side effect.
Hypersensitive test: utilizing Cavia porcellus to do hypersensitive test, result shows: this herbal mixture oral liquid does not has anaphylaxis.

Claims (2)

1. herbal mixture treating cattle diarrhea due to damp-heat and preparation method thereof, its prescription is by Herba Erodii 40g, Radix Sanguisorbae 40 g, sweet Grass 25 g, Fructus Foeniculi 30 g, four taste Chinese medicine compositions.
2. herbal mixture treating cattle diarrhea due to damp-heat and preparation method thereof is as follows: (1) weigh Herba Erodii 40 g in prescription, Above-mentioned four taste Chinese medicines are mixed by Radix Sanguisorbae 40 g, Radix Glycyrrhizae 25 g, Fructus Foeniculi 30 g;(2) 1300 mL that add water for the first time soak 1 Decoct after h, after intense fire boils, slow fire boiling 1.5 h, filters, takes filtrate;Second time adds 1040 mL soak by water, intense fire After boiling, slow fire boiling 1 h, filters, takes filtrate;(3) by twice decoct medicinal liquid merge, utilize 8 layers of filtered through gauze, filtrate with 3000 r/min are centrifuged 10 min, take supernatant, abandon precipitation;(4) utilize Rotary Evaporators by supernatant concentration to 67.5 mL, Preparing crude drug content is 2.0 g/mL water decoctions;(5) prepared water decoction is packed, it is thus achieved that liquid medicine in commodity Decoct.
CN201610612165.3A 2016-07-31 2016-07-31 A kind of Chinese medicinal formulae treating cattle diarrhea due to damp-heat and preparation method thereof Pending CN106074785A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107362241A (en) * 2017-06-30 2017-11-21 河南黑马动物药业有限公司 A kind of ox heat for the treatment of rushes down Chinese traditional medicine composition side of disease and preparation method thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102894229A (en) * 2012-10-24 2013-01-30 刘向前 Natural feed additive with functions of relieving diarrhea, resisting bacteria and eliminating inflammation and preparation method thereof
CN103028069A (en) * 2010-12-01 2013-04-10 苏州知微堂生物科技有限公司 Preparation technology and production method of integrated new dosage form of Tieshua decoction

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103028069A (en) * 2010-12-01 2013-04-10 苏州知微堂生物科技有限公司 Preparation technology and production method of integrated new dosage form of Tieshua decoction
CN102894229A (en) * 2012-10-24 2013-01-30 刘向前 Natural feed additive with functions of relieving diarrhea, resisting bacteria and eliminating inflammation and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
廖振云 等: "一起中猪特殊腹泻病例的诊治" *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107362241A (en) * 2017-06-30 2017-11-21 河南黑马动物药业有限公司 A kind of ox heat for the treatment of rushes down Chinese traditional medicine composition side of disease and preparation method thereof

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Application publication date: 20161109