CN108785633A - 一种治疗慢性腹泻的中药组合物及其制剂 - Google Patents
一种治疗慢性腹泻的中药组合物及其制剂 Download PDFInfo
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Abstract
本发明公开了一种治疗慢性腹泻的中药组合物及其制剂,由以下重量份数的原料组成:黄芪10~30份,白术5~20份,薏苡仁12~25份,广藿香4~18份,升麻3~18份,陈皮1~15份,白芍8~24份,荆芥穗6~24份,乌梅10~28份,石榴皮10~28份,桂枝5~16份,干姜5~16份。本发明提供了一种治疗慢性腹泻的中药组合物及其制剂,该中药制剂健脾温肾,益火培土,化湿止泻,用于泄泻病脾胃虚弱证、肾阳虚衰证引起的慢性腹泻。
Description
技术领域
本发明涉及医药制作的技术领域,特别涉及一种治疗慢性腹泻的中药组合物及其制剂。
背景技术
慢性腹泻是临床上常见症状,只要是以大便次数增多,粪质稀薄,甚至泻出如水样为主症的病证,病程一般超过3月以上。症状以大便次数增多,粪质稀薄为主要症状,可伴有腹痛肠鸣、脘痞食少、泛恶纳呆;或胸胁胀闷、喜叹息、嗳气、矢气频作、肠鸣即泻、泻后则安;形寒肢冷、腰膝酸软或面色萎黄、肢倦乏力等症状。致泻的病因是多方面的,主要有感受外邪,饮食所伤,情志失调,脾胃虚弱,命门火衰等等。这些病因导致脾虚夹湿,脾失健运,大小肠传化失常,升降失调,清浊不分,而成泄泻。
而脾肾阳虚,水湿内盛是本病最多见、最重要的原因。命门之火,助脾胃之运化以腐熟水谷。若年老体弱,肾气不足;或久病之后,肾阳受损;或房室无度,命门火衰,致脾失温煦,运化失职,水谷不化,升降失调,清浊不分,而成泄泻。且肾为胃之关,主司二便,若肾气不足,关门不利,则可发生大便滑泄、洞泄。《景岳全书·泄泻》曰:“肾为胃关,开窍于二阴,所以二便之开闭,皆肾脏之所主,今肾中阳气不足,则命门火衰,而阴寒独盛,故于子丑五更之后,当阳气未复,阴气盛极之时,即令人洞泄不止也。”本病既为脾肾阳虚,寒湿内盛所致,故当以健脾温肾,益火培土,化湿止泻,佐以缓急止痛为法,止泻颗粒组方正是遵循上述中医理论基础而成。
发明内容
本发明的目的在于:针对上述存在的问题,提供一种治疗慢性腹泻的中药组合物及其制剂,该中药制剂健脾温肾,益火培土,化湿止泻,用于泄泻病脾胃虚弱证、肾阳虚衰证引起的慢性腹泻。
为了实现上述发明目的,本发明采用的技术方案如下:
一种治疗慢性腹泻的中药组合物,由以下重量份数的原料组成:黄芪10~30份,白术5~20份,薏苡仁12~25份,广藿香4~18份,升麻3~18份,陈皮1~15份,白芍8~24份,荆芥穗6~24份,乌梅10~28份,石榴皮10~28份,桂枝5~16份,干姜5~16份。
所述中药组合物具体由以下重量份数的原料组成:黄芪15~22份,白术8~15份,薏苡仁15~22份,广藿香6~15份,升麻5~15份,陈皮3~10份,白芍10~20份,荆芥穗10~20份,乌梅15~25份,石榴皮15~25份,桂枝8~12份,干姜8~12份。
所述中药组合物具体由以下重量份数的原料组成:黄芪18~20份,白术10~12份,薏苡仁18~20份,广藿香8~12份,升麻8~12份,陈皮5~8份,白芍13~18份,荆芥穗13~18份,乌梅16~20份,石榴皮16~20份,桂枝9~10份,干姜9~10份。
以下是本发明中药组合物药材的来源:
黄芪,拉丁名为Leguminosae,别名北芪、北蓍,黄芪属,为豆科草本植物蒙古黄芪、膜荚黄芪的干燥根。性温、味甘、微甜。具有具有补气固表,利尿托毒,排脓,敛疮生肌的作用。
白术,拉丁学名Atractylodes macrocephala。别名桴蓟,于术,冬白术,淅术,杨桴,吴术,片术、苍术等,属于菊科、苍术属多年生草本植物。喜凉爽气候,以根茎入药,具有多项药用功能。
薏苡仁,为禾本科植物薏苡Coix lacryma-jobi L.var.mayuen(Roman.)Stapf的干燥成熟种仁。秋季果实成熟时采割植株,晒干,打下果实,再晒干,除去外壳、黄褐色种皮和杂质,收集种仁。
广藿香,中药名。为唇形科植物广藿香Pogostemon cablin(Blanco)Benth.的干燥地上部分。枝叶茂盛时采割,日晒夜闷,反复至干。
升麻,别名:龙眼根、周麻、窟窿牙根,为毛茛科、升麻属植物大三叶升麻、兴安升麻或升麻的根茎。
陈皮,中药名。为芸香科植物橘Citrus reticulataBlanco及其栽培变种的干燥成熟果皮。药材分为“陈皮”和“广陈皮”。采摘成熟果实,剥取果皮,晒干或低温干燥。
白芍是毛茛科白芍属植物,是毛莨科植物芍药的干燥根。夏、秋二季采挖,洗净,除去头尾和细根,置沸水中煮后除去外皮或去皮后再煮,晒干。
荆芥穗,中药名。为唇形科植物荆芥Schizonepeta tenusfolia Briq.的干燥花穗。夏、秋二季花开到顶、穗绿时采摘,除去杂质,晒干。
乌梅,中药名。为蔷薇科植物梅Prunus mume(Sieb.)Sieb.etZuce.的干燥近成熟果实。
石榴皮,中药名。为石榴科植物石榴Punica granatum L.的干燥果皮。
桂枝,别名:柳桂(学名:Cinnamomum cassia Presl)为樟科植物肉桂Cinnamomumcassia Presl的干燥嫩枝。
干姜,为姜科植物姜Zingiber officinale Rosc.的干燥根茎。辛、热。干姜温中散寒,回阳通脉,燥湿消痰。用于脘腹冷痛,呕吐泄泻,肢冷脉微,痰饮喘咳。
本发明的另一目的是提供本发明中药组合物制成制剂的有效成分的制备方法,该方法是采用水或者50~60%的乙醇提取制备而成。具体制备方法如下:
方案一:取全部中药切成饮片,加入清水浸泡20~30min,使用武火煎煮使药液沸腾,使用文火煎煮30~40min,添加适量清水,继续煎煮40~50min,每次添加的清水量为中药总质量的8~10倍,过滤的,将滤液蒸发浓缩得到清膏即为有效成分。
方案二:取全部药材切成饮片,加入50~60%的乙醇渗漉提取3~5次,每次使用乙醇的量为药材总质量的8~10倍,过滤,合并提取液,浓缩至密度为1.08~1.15得到清膏即为有效成分。
方案三:取全部药材加入水煎煮2次,每次加水的量为中药的8~10倍,每次煎煮40~50min,煎煮完成后过滤,将滤渣使用50~60%的乙醇渗漉提取2~3次,每次使用乙醇的量为药材总质量的8~10倍,过滤,合并所有的提取液,蒸发浓缩至密度为1.08~1.15得到的浸膏即为有效成分。
方案四:所述中药制剂通过以下方法制备而成:去全部药材加入乙醇渗漉提取2~3次,每次使用乙醇的量为药材总质量的8~10倍,过滤,得到的滤渣在加入8~10倍的水煎煮2次,每次煎煮40~50min,过滤,将所有提取液混合蒸发浓缩至密度为1.08~1.15得到的浸膏即为有效成分。
本发明所述的治疗慢性腹泻的中药组合物,还可以与医药学上可接受的载体配合,制成各种制剂,如片剂、胶囊剂、口服液、糖浆剂、合剂、颗粒剂等。
本发明的药学上可接受的载体包括但不限于以下:
稀释剂:淀粉、糖粉、乳糖、糊精、微晶纤维素、无机盐、糖醇类等。
润湿剂与粘合剂:纯化水、乙醇、明胶、聚乙二醇、纤维素衍生物等。
崩解剂:淀粉、羧甲基淀粉钠、纤维素衍生物、交联聚维酮等。
润滑剂:硬脂酸镁、微粉硅胶、滑石粉、聚乙二醇等。
助溶剂:水、乙醇、甘油、丙二醇、液状石蜡、植物油等。
矫味剂:蔗糖、单糖、芳香剂等。
防腐剂:苯甲酸、山梨酸、甲酯、乙酯、丙酯等。
方法1:片剂
取方案一至方案三所得有效成分之一,加入片剂常用辅料,按常规生产方法制备得本发明片剂。
上述片剂常用辅料包括稀释剂、润湿剂、粘合剂、崩解剂、润滑剂之一或全部。
方法2:胶囊剂
取方案一至方案三所得有效成分之一,加入胶囊剂常用辅料,按常规生产方法制备得本发明胶囊剂。
上述胶囊剂常用辅料包括稀释剂、润湿剂、粘合剂、崩解剂、润滑剂之一或全部。
方法3:糖浆剂
取方案一至方案三所得有效成分之一,加入糖浆剂常用辅料,按常规生产方法制备得本发明糖浆剂。
上述糖浆剂常用辅料包括矫味剂、防腐剂、助溶剂之一或全部。
方法4:合剂
取方案一至方案三所得有效成分之一,加入合剂常用辅料,按常规生产方法制备得本发明合剂。
上述合剂常用辅料包括矫味剂、防腐剂之一或全部。
方法5:口服液
取方案一至方案三所得有效成分之一,溶解后净化、浓缩,加入口服液常用辅料,按常规生产方法制备得本发明口服液。
上述口服液常用辅料包括矫味剂、防腐剂、助溶剂之一或全部。
方法6:颗粒剂
取方案一至方案三所得有效成分之一,加入颗粒剂常用辅料,按常规生产方法制备得本发明颗粒剂。
上述颗粒剂常用辅料包括稀释剂、润湿剂、粘合剂、崩解剂、润滑剂之一或全部。
本发明的中药组合物主要由黄芪、白术、薏苡仁、广藿香、升麻、陈皮、白芍、荆芥穗、乌梅、石榴皮、桂枝、干姜十二味中药材中药组成,具有健脾温肾,益火培土,化湿止泻之功效,主要用于脾胃虚弱、肾阳虚衰证引起的慢性腹泻病的治疗。本发明的中药组合物及其制剂是为脾肾阳虚,水湿内盛引起的慢性腹泻而设,以黄芪、干姜为君药;以薏苡仁、桂枝为臣药;以广藿香、升麻、陈皮、白芍、荆芥穗、乌梅、石榴皮为佐药,白术为使药,共成健脾温肾,益火培土,化湿止泻,缓急止痛之剂。其中黄芪,甘,微温。归脾、肺经。有健脾补中,升阳举陷的功效。薏苡仁性甘、淡,凉,归脾、胃、肺经功在利水渗湿,健脾,淡渗甘补,既利水,又健脾补中,能渗除脾湿,健脾止泻,尤宜治脾虚夹湿之泄泻。桂枝性辛、甘,温。归心、肺、膀胱经。能温通经脉,助阳化气,既可温扶脾阳以助运水,又可温肾阳、逐寒邪以助膀胱气化,而行水湿痰饮之邪。广藿香性辛,微温。归脾、胃、肺经。长于化湿,本品气味芳香,为芳香化湿浊要药。又因其性微温,故多用于寒湿困脾所致的泄泻、脘腹痞闷,少食体倦等症。升麻辛、微甘,微寒。归肺、脾、胃、大肠经。在此用其升举阳气之功,本品入脾胃经,善引脾胃清阳之气上升,其升提之力较强。故常用治中气不足,气虚下陷所致的久泄,甚至久泻脱肛,脏器下垂、脱垂等,多与黄芪同用,以补气升阳。陈皮性辛、苦,温,归脾、肺经,能理气健脾,燥湿化痰。本品辛行温通,有行气止痛、健脾和中之功,因其苦温而燥,故寒湿阻中之气滞最宜。白芍性味苦、酸,微寒,归肝、脾经,功效养血敛阴,柔肝止痛,平抑肝阳。本品酸敛肝阴,养血柔肝,缓急止痛,疗脾虚肝旺,腹痛泄泻,缓解胃肠痉挛。荆芥穗性味辛,微温,归肺、肝经,长于祛风止痛。陈皮、白芍、荆芥橞三者合为痛泻要方之意,可以补脾土而泻肝木,调气机以止痛泻。乌梅酸、涩,平,归肝、脾、肺、大肠经,功在涩肠止泻,用于久泻,久痢。石榴皮酸、涩,温。归大肠经,亦善于涩肠止泻,收敛止血。本品酸涩收敛,入大肠经,能涩肠道,止泻痢,为治疗久泻久痢之常用药物。诸药合用共成健脾温肾,益火培土,化湿止泻之剂,用于脾肾阳虚,水湿内盛引起的慢性腹泻病的治疗。白术甘苦温无毒,调和诸药。
综上所述,由于采用了上述技术方案,具有以下有益效果:
(1)本发明组方严谨,其中黄芪甘温,善入脾胃,为补中益气要药。脾气虚弱,倦怠乏力,食少便溏、适合泄泻者使用,故长于治疗脾虚中气下陷之久泻脱肛,内脏下垂。对于脾虚失水,以致久泄者,既能补脾益气,又能升阳举陷,标本兼治,为治慢性泄泻之要药。干姜具有温中散寒,回阳通脉的功效,用于脘腹冷痛,呕吐泄泻,肢冷脉微,寒饮喘咳。主入脾胃而长于温中散寒、健运脾阳,为温暖中焦之主药,通过健脾渗湿而止泻,尤宜于脾虚夹湿泄泻;薏苡仁用与助黄芪健脾之力,桂枝可温扶脾阳以助运水,又可温肾阳、逐寒邪以助膀胱气化;广藿香入脾胃经,善引脾胃清阳之气上升,其升提之力较强,多与黄芪同用;陈皮有行气止痛、健脾和中的功效,白芍酸敛肝阴,养血柔肝,缓急止痛,疗脾虚肝旺,腹痛泄泻,缓解胃肠痉挛;荆芥穗补脾土而泻肝木,调气机以止痛泻;乌梅有良好的涩肠止泻痢作用。
(2)本发明的中药组合物及其制剂经临床试验证明,对慢性腹泻的治愈率达61.6%,总有效率为91.9%,可见本发明中药组合物及其制剂可以有效治疗慢性腹泻,经临床观察表明,本发明中药组合物及其制剂对慢性腹泻有显著疗效,疗效迅速,患者普遍在服药1个疗程后就可感到明显减轻或消失,且未见异常变化和不良反应,停药后病情不出现副作用,临床服用安全可靠。
(3)本发明的中药组合物制成多种制剂,服用、携带方便,满足不同病况的病患服用和携带,适用人群广。
(4)本发明的中药组合物及其制剂配方科学合理,副作用小,制备方法简单,制备成本低,可大大减轻患者的身体和经济负担,具有很大的推广价值。
具体实施方式
为使本发明的目的、技术方案及优点更加清楚明白,以下举出优选实施例,对本发明进一步详细说明。然而,需要说明的是,说明书中列出的许多细节仅仅是为了使读者对本发明的一个或多个方面有一个透彻的理解,即便没有这些特定的细节也可以实现本发明的这些方面。
一、制备治疗痛风及风湿疼痛的民族药泡洗液
实施例1片剂
黄芪10份,白术5份,薏苡仁12份,广藿香4份,升麻3份,陈皮1份,白芍8份,荆芥穗6份,乌梅10份,石榴皮10份,桂枝5~16份,干姜5份。
取全部中药切成饮片,加入清水浸泡20min,使用武火煎煮使药液沸腾,使用文火煎煮30min,添加适量清水,继续煎煮40min,每次添加的清水量为中药总质量的8倍,过滤的,将滤液蒸发浓缩得到清膏即为有效成分,加入片剂辅料糊精、滑石粉、羧甲基淀粉钠、纤维素衍生物,按常规方案制得片剂。
实施例2片剂
黄芪30份,白术20份,薏苡仁25份,广藿香18份,升麻18份,陈皮15份,白芍24份,荆芥穗24份,乌梅28份,石榴皮28份,桂枝16份,干姜16份。
取全部中药切成饮片,加入清水浸泡30min,使用武火煎煮使药液沸腾,使用文火煎煮40min,添加适量清水,继续煎煮50min,每次添加的清水量为中药总质量的10倍,过滤的,将滤液蒸发浓缩得到清膏即为有效成分,加入片剂辅料糊精、滑石粉、羧甲基淀粉钠、纤维素衍生物,按常规方案制得片剂。
实施例3胶囊剂
黄芪15份,白术8份,薏苡仁15份,广藿香6份,升麻5份,陈皮3份,白芍10份,荆芥穗10份,乌梅15份,石榴皮15份,桂枝8份,干姜8份。
取全部药材切成饮片,加入50%的乙醇渗漉提取3次,每次使用乙醇的量为药材总质量的8倍,过滤,合并提取液,浓缩至密度为1.08得到清膏即为有效成分,加入胶囊剂辅料淀粉、乙醇、硬脂酸镁,按常规方案制得胶囊剂。
实施例4胶囊剂
黄芪22份,白术15份,薏苡仁22份,广藿香15份,升麻15份,陈皮10份,白芍20份,荆芥穗20份,乌梅25份,石榴皮25份,桂枝12份,干姜12份。
取全部药材切成饮片,加入60%的乙醇渗漉提取5次,每次使用乙醇的量为药材总质量的10倍,过滤,合并提取液,浓缩至密度为1.15得到清膏即为有效成分,在清膏中加入胶囊剂辅料羧甲基淀粉钠、微晶纤维素、微粉硅胶、聚乙二醇,按常规方案制得胶囊剂。
实施例5糖浆剂
黄芪18份,白术10份,薏苡仁18份,广藿香8份,升麻8份,陈皮5份,白芍13份,荆芥穗13份,乌梅16份,石榴皮16份,桂枝9份,干姜9份。
取全部药材加入水煎煮2次,每次加水的量为中药的8倍,每次煎煮40min,煎煮完成后过滤,将滤渣使用50%的乙醇渗漉提取2次,每次使用乙醇的量为药材总质量的8倍,过滤,合并所有的提取液,蒸发浓缩至密度为1.08得到的浸膏即为有效成分,在清膏中加入糖浆剂辅料单糖、山梨酸及水搅拌均匀,制得糖浆剂。
实施例6
黄芪20份,白术12份,薏苡仁20份,广藿香12份,升麻12份,陈皮8份,白芍18份,荆芥穗18份,乌梅20份,石榴皮20份,桂枝10份,干姜10份。
取全部药材加入水煎煮2次,每次加水的量为中药的10倍,每次煎煮50min,煎煮完成后过滤,将滤渣使用60%的乙醇渗漉提取3次,每次使用乙醇的量为药材总质量的10倍,过滤,合并所有的提取液,蒸发浓缩至密度为1.15得到的浸膏即为有效成分,在清膏中加入糖浆剂辅料单糖、山梨酸及水搅拌均匀,制得糖浆剂。
实施例7合剂
黄芪18~20份,白术10~12份,薏苡仁18~20份,广藿香8~12份,升麻8~12份,陈皮5~8份,白芍13~18份,荆芥穗13~18份,乌梅16~20份,石榴皮16~20份,桂枝9~10份,干姜9~10份。
去全部药材加入乙醇渗漉提取2~3次,每次使用乙醇的量为药材总质量的8~10倍,过滤,得到的滤渣在加入8~10倍的水煎煮2次,每次煎煮40~50min,过滤,将所有提取液混合蒸发浓缩至密度为1.08~1.15得到的浸膏即为有效成分,在浸膏中加入合剂辅料蔗糖、苯甲酸,搅拌均匀,制得合剂。
实施例8口服液
黄芪15份,白术12份,薏苡仁18份,广藿香12份,升麻10份,陈皮7份,白芍15份,荆芥穗15份,乌梅18份,石榴皮18份,桂枝10份,干姜10份。
去全部药材加入乙醇渗漉提取2次,每次使用乙醇的量为药材总质量的9倍,过滤,得到的滤渣在加入9倍的水煎煮2次,每次煎煮40min,过滤,将所有提取液混合蒸发浓缩至密度为1.10得到的浸膏即为有效成分,在清膏中加入口服液辅料山梨酸、甲酯、水搅拌均匀,分装,制得口服液。
实施例9颗粒剂
黄芪15份,白术12份,薏苡仁18份,广藿香12份,升麻10份,陈皮7份,白芍15份,荆芥穗15份,乌梅18份,石榴皮18份,桂枝10份,干姜10份。
取全部药材加入乙醇渗漉提取3次,每次使用乙醇的量为药材总质量的10倍,过滤,得到的滤渣在加入10倍的水煎煮2次,每次煎煮50min,过滤,将所有提取液混合蒸发浓缩至密度为1.10得到的浸膏即为有效成分,在清膏中加入辅料乳糖、明胶、淀粉、微晶纤维素,制粒、干燥、整粒,制得颗粒剂。
实施例10颗粒剂
黄芪15份,白术12份,薏苡仁18份,广藿香12份,升麻10份,陈皮7份,白芍15份,荆芥穗15份,乌梅18份,石榴皮18份,桂枝10份,干姜10份。
取全部药材加入乙醇渗漉提取3次,每次使用乙醇的量为药材总质量的10倍,过滤,得到的滤渣在加入10倍的水煎煮2次,每次煎煮50min,过滤,将所有提取液混合蒸发浓缩至密度为1.10得到的浸膏即为有效成分,在浸膏中加入辅料糊精、水、聚乙二醇、交联聚维酮,制粒、干燥、整粒,制得颗粒剂。
二、临床实验总结
(1)基本资料
选择慢性腹泻临床观察病例86例,其中男45例,女43例,年龄25~50岁。病程最短者60天,最长者长达3年,平均1.1年。
(2)诊断标准
1、大便稀薄如水样,次数增多。可伴腹胀腹痛等症;
2、慢性久泻起病缓慢,病程较长,反复发作,时轻时重;
3、饮食不当、受寒凉或情绪变化可诱发;
4、必要时作X线钡剂灌肠或纤维肠镜检查。
(3)治疗方法
使用本发明实施例3给予治疗,每天3次,早中晚各一次,每次2g,5天为一疗程。
(4)疗效判断标准
主要依据该疾病症状是否消失,具体分为三个等级:
痊愈:大便正常,其他症状消失,临床检验正常;
好转:大便次数明显减少,其他症状改善;
未愈:症状未见改善。
(3)治疗效果见表1
效果 | 痊愈 | 好转 | 未愈 |
人数/人 | 53 | 26 | 7 |
占比/% | 61.6 | 30.3 | 8.1 |
由上表可知,用本发明制备的治疗慢性腹泻的中药制剂的有效率占比91.9%,治疗效果明显且无副作用。
四、典型病例:
病例1:李某,男,42岁,半年前无明显诱因的情况下出现腹泻,进食后腹泻次数增多达6次,伴乏力、腹中肠鸣,无腹痛、腹胀,无恶心、呕吐,无发热畏寒,半年内,体重明显减轻5kg。使用本发明实施例3的胶囊服用一个疗程后,腹泻次数明显减少,服用4个疗程后慢性腹泻症状消失,精力有所改善。
病例2:陈某,女,49岁,长期腹泻有2年余,病情迁延反复,大便次数5~7次/日,粪质稀薄,肠鸣即泻,泻后则安,伴有肠鸣、脘痞食少、泛恶纳呆,腰膝酸软,面色萎黄、肢倦乏力,服用本发明实施例4制备的胶囊一个疗程后,每日大便次数减少为2~3次,服用三个疗程后痊愈,且无其他不适症状出现。
病例3:黄某,女,32岁,多年大便溏薄,夹有不消化食物,稍有油腻则大便次数多,伴有神疲乏力,舌质淡,脉细,服用本发明中实施例10制备的颗粒一个疗程后,大便明显减少,继续服用2个疗程,痊愈且未见复发。
综合以上所述,本发明的治疗慢性腹泻的中药组合物及其制剂治疗效果好,安全可靠,无副作用。
以上所述仅是本发明的优选实施方式,应当指出,对于本技术领域的普通技术人员来说,在不脱离本发明原理的前提下,还可以作出若干改进和润饰,这些改进和润饰也应视为本发明的保护范围。
Claims (9)
1.一种治疗慢性腹泻的中药组合物,其特征在于:由以下重量份数的原料组成:黄芪10~30份,白术5~20份,薏苡仁12~25份,广藿香4~18份,升麻3~18份,陈皮1~15份,白芍8~24份,荆芥穗6~24份,乌梅10~28份,石榴皮10~28份,桂枝5~16份,干姜5~16份。
2.根据权利要求1所述的一种治疗慢性腹泻的中药组合物,其特征在于:所述中药组合物具体由以下重量份数的原料组成:黄芪15~22份,白术8~15份,薏苡仁15~22份,广藿香6~15份,升麻5~15份,陈皮3~10份,白芍10~20份,荆芥穗10~20份,乌梅15~25份,石榴皮15~25份,桂枝8~12份,干姜8~12份。
3.根据权利要求2所述的一种治疗慢性腹泻的中药组合物,其特征在于:所述中药组合物具体由以下重量份数的原料组成:黄芪18~20份,白术10~12份,薏苡仁18~20份,广藿香8~12份,升麻8~12份,陈皮5~8份,白芍13~18份,荆芥穗13~18份,乌梅16~20份,石榴皮16~20份,桂枝9~10份,干姜9~10份。
4.一种治疗慢性腹泻的中药制剂,由权利要求1~3中任一项所述的治疗慢性腹泻的中药组合物与医药学上可接受的载体配合制备而成。
5.根据权利要求4所述的一种治疗慢性腹泻的中药制剂,其特征在于:所述中药制剂的有效成分是由其中药组合物采用水或者50~60%的乙醇提取制备而成。
6.根据权利要求5所述的一种治疗慢性腹泻的中药组合物及其制剂,其特征在于:所述中药制剂通过以下方法制备而成:取全部中药切成饮片,加入清水浸泡20~30min,使用武火煎煮使药液沸腾,使用文火煎煮30~40min,添加适量清水,继续煎煮40~50min,每次添加的清水量为中药总质量的8~10倍,过滤的,将滤液蒸发浓缩得到清膏即为有效成分。
7.根据权利要求5所述的一种治疗慢性腹泻的中药组合物及其制剂,其特征在于:所述中药制剂通过以下方法制备而成:取全部药材切成饮片,加入50~60%的乙醇渗漉提取3~5次,每次使用乙醇的量为药材总质量的8~10倍,过滤,合并提取液,浓缩至密度为1.08~1.15得到清膏即为有效成分。
8.根据权利要求5所述的一种治疗慢性腹泻的中药组合物及其制剂,其特征在于:所述中药制剂通过以下方法制备而成:取全部药材加入水煎煮2次,每次加水的量为中药的8~10倍,每次煎煮40~50min,煎煮完成后过滤,将滤渣使用50~60%的乙醇渗漉提取2~3次,每次使用乙醇的量为药材总质量的8~10倍,过滤,合并所有的提取液,蒸发浓缩至密度为1.08~1.15得到的浸膏即为有效成分。
9.根据权利要求5所述的一种治疗慢性腹泻的中药组合物及其制剂,其特征在于:所述中药制剂通过以下方法制备而成:取全部药材加入乙醇渗漉提取2~3次,每次使用乙醇的量为药材总质量的8~10倍,过滤,得到的滤渣在加入8~10倍的水煎煮2次,每次煎煮40~50min,过滤,将所有提取液混合蒸发浓缩至密度为1.08~1.15得到的浸膏即为有效成分。
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