CN108771658A - A kind of bowel relaxing oral liquid and preparation method - Google Patents

A kind of bowel relaxing oral liquid and preparation method Download PDF

Info

Publication number
CN108771658A
CN108771658A CN201810943118.6A CN201810943118A CN108771658A CN 108771658 A CN108771658 A CN 108771658A CN 201810943118 A CN201810943118 A CN 201810943118A CN 108771658 A CN108771658 A CN 108771658A
Authority
CN
China
Prior art keywords
parts
fruit
oral liquid
spare
bowel relaxing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201810943118.6A
Other languages
Chinese (zh)
Inventor
秦令祥
高鹏
高愿军
崔胜文
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Henan Sunset Blue Food Technology Co Ltd
Original Assignee
Henan Sunset Blue Food Technology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Henan Sunset Blue Food Technology Co Ltd filed Critical Henan Sunset Blue Food Technology Co Ltd
Priority to CN201810943118.6A priority Critical patent/CN108771658A/en
Publication of CN108771658A publication Critical patent/CN108771658A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/733—Fructosans, e.g. inulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
    • A61K35/644—Beeswax; Propolis; Royal jelly; Honey
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/285—Aucklandia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A61K36/428—Trichosanthes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488—Pueraria (kudzu)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/64—Orobanchaceae (Broom-rape family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708—Rheum (rhubarb)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815—Lycium (desert-thorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/84—Valerianaceae (Valerian family), e.g. valerian
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8964—Anemarrhena
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Molecular Biology (AREA)
  • Insects & Arthropods (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a kind of bowel relaxing oral liquid, contained component raw material and its parts by weight are：2 ~ 5 parts of oligofructose, 0.5 ~ 0.9 part of xylo-oligosaccharide, 0.5 ~ 2.5 part of stachyose, 2 ~ 5 parts of inulin, 5 ~ 9 parts of honey, 30 ~ 45 parts of Herba Cistanches, 25 ~ 30 parts of the fruit of Chinese wolfberry, 25 ~ 35 parts of pueraria lobata, 10 ~ 15 parts of rheum officinale, Rhizoma Atractylodis Macrocephalae 25 ~ 30,15 ~ 25 parts of Radix Angelicae Sinensis, 20 ~ 28 parts of Poria cocos, 8 ~ 16 parts of corydalis tuber, 5 ~ 9 parts of root of Aucklandia lappa Decne, 6 ~ 10 parts of rhizoma anemarrhenae, 5 ~ 9 parts of full Snakegourd Fruit, 5 ~ 7 parts of field pennycress, 5 ~ 7 parts of rice bean flower, 4 ~ 6 parts of Radix Glycyrrhizae.Bowel relaxing oral liquid provided by the invention prepares simple, active constituent content height, and intestines peristalsis, invigorating the kidney and spleen, clearing heat and moistening lung, enhancing contraction of muscle ability can be promoted to improve the feeling kinetic energy of rectum, have apparent therapeutic effect to constipation and multiple complications.

Description

A kind of bowel relaxing oral liquid and preparation method
Technical field
The present invention relates to technical field of traditional Chinese medicines, and in particular to a kind of bowel relaxing oral liquid and preparation method.
Background technology
Constipation refers to that moisture was made the excessively dry scleroma of excrement, made large intestine by excessive consumption too long the residence time in enteric cavity At difficult defecation.Constipation influences health huge：For constipation patient since the excrement block length time is detained enteron aisle, abnormal fermentation is rotten A large amount of harmful toxin can be generated after losing, easily raw acne, facial pigmentation, fash etc.；Toxin leads to large intestine oedema, the lower part of the body Blood circulation slows down, and easily forms pyriform stature and fat belly；Constipation can make abdomen turgor, generate nausea, apocleisis, food and it is tasteless； Constipation patient can have the symptoms such as irritated, confused and worried, insomnia；Chronic constipation patient is since long-term pelvic muscle stimulates, Chang Keyin Sore warp；Constipation patient can concurrently anal intestine disease, such as hemorrhoid, anal fissure, rectal prolapse；Harmful toxins persistently stimulate intestinal mucosa, easily Lead to colorectal cancer.
The drug of existing treatment constipation is mostly the drug for rushing down lower function, easy tos produce pharmacological dependence, and long term usage consumes human body Vigour, other such as probiotics conditioning, food therapy slowly effects, and these therapies are not thorough in the presence for the treatment of, are easy lacking for recurrence Point.Chinese herbs decoction has certain therapeutic effect, but is difficult to the deficiency swallowed, medicining cycle is grown in the presence of time-consuming, taste bitterness is decocted. It finds that convenient to take, in good taste, curative effect is ideal, toxic side effect is small, functions of intestines and stomach, radical cure constipation can be improved, improve physical function Drug it is very necessary.
Invention content
In view of the deficiency of existing treatment constipation drug, present invention offer one kind is in good taste, toxic side effect is small, constipation cure rate High bowel relaxing oral liquid and preparation method thereof, specific technical solution are as follows：
A kind of bowel relaxing oral liquid, contained component raw material and its parts by weight are：2~5 parts of oligofructose, xylo-oligosaccharide 0.5~0.9 part, 0.5~2.5 part of stachyose, 2~5 parts of inulin, 5~9 parts of honey, 30~45 parts of Herba Cistanches, the fruit of Chinese wolfberry 25~30 Part, 25~35 parts of pueraria lobata, 10~15 parts of rheum officinale, Rhizoma Atractylodis Macrocephalae 25~30,15~25 parts of Radix Angelicae Sinensis, 20~28 parts of Poria cocos, corydalis tuber 8~16 Part, 5~9 parts of root of Aucklandia lappa Decne, 6~10 parts of rhizoma anemarrhenae, 5~9 parts of full Snakegourd Fruit, 5~7 parts of field pennycress, 5~7 parts of rice bean flower, Radix Glycyrrhizae 4~6 Part.
A kind of preparation method of bowel relaxing oral liquid, includes the following steps：
Step 1: bulk pharmaceutical chemicals are handled：The fruit of Chinese wolfberry cleans, cleans, it is spare to dry；Full Snakegourd Fruit, rice bean flower removal of impurities, clean, Drying in the shade, it is spare to smash to pieces；Herba Cistanches, Radix Angelicae Sinensis, Poria cocos, Radix Glycyrrhizae removal of impurities, are cleaned, cut into serving pieces pueraria lobata；Bighead atractylodes rhizome piece bran is fried, and is fried to Rhizoma Atractylodis Macrocephalae In yellowish-brown, takes out, weed out wheat bran, cool spare；Corydalis tuber vinegar system dries in the air to sixty percent dry, cuts sheet, smashed to pieces after drying spare； Root of Aucklandia lappa Decne simmers system, cools, spare；Rhizoma anemarrhenae piece salt system, dries in the air cool, weeds out clast；Field pennycress removes impurity, sprays clear water, slightly moistens, cut Section, is dried, and is fried to black with the slow fire of firewood, micro- watering is dried spare；
Step 2: traditional Chinese medicine extraction：By the processed each component of step 1, the clear water of 4 times of amounts is added to impregnate 1~2h, then 20kHz, 120W are ultrasonically treated 40min, filtering, and then 40kHz, 120W supersound process 20min, filtering filtrate will merge twice, The liquid of relative density 1.2 when being concentrated under reduced pressure into 60 DEG C stands cooling and takes supernatant, add ethyl alcohol, stand 24 hours, filter, returns Ethyl alcohol is to get the concentrated liquid of tradition Chinese medicine in receipts filtrate；
Step 3: allotment, homogeneous：The oligomeric fruit of corresponding parts by weight is added in the concentrated liquid of tradition Chinese medicine obtained to step 1 Sugar, xylo-oligosaccharide, stachyose, inulin, honey, add water to stir, homogeneous under the conditions of 40~50 DEG C of temperature, 25~40MPa of pressure；
Step 4: packing, sterilizing：Mixed liquor after homogeneous is subjected to filling, sterilizing, thus obtaining the product product.
Preferably, add ethyl alcohol to alcohol content 70% in step 2.
Chinese medicine thinks, large intestine is the organ in charge of transportation, compound go out here, post transmits waste matter, and in lung each other table.The respectful drop of lung qi Then big internal organs gas is unobstructed, and discrepancy has often.If intemperance of taking food, work and rest immoderation, taking good care of oneself improper causes damp and hot heresy to tie in large intestine, body fluid It is short, venation block, qi depression to blood stasis, FU QI being obstructed then constipation are caused, internal harmful substance is made to can not rule out and influence other Internal organs extend cause the more viscera function obstacles of taste kidney at any time.Though therefore constipation disease in large intestine, with other internal organs, channels and collaterals, gas Blood, body fluid are closely related, be negative and positive, internal organs, Qi dysfunction a kind of topical manifestations.
Chinese prescription of the present invention is seted forth one's views, with " kidney-replenishing blood-nourishing, invigorating the spleen benefit from entirety with " kidney and spleen invigorating, the ease constipation of reason lung " Gas, nourishing Yin and moistening lung, clearing heat and promoting fluid " is the rules for the treatment of, enriching yin and nourishing kidney, tonify deficiency benefit health, strengthening spleen and nourishing stomach, clearing heat and moistening lung, makes that kidney qi is sufficient, spleen The strong fortune of gas, the smooth blood of gas is living, body fluid is full, internal organs transporting degree of having, large intestine degree of having actuated, lifting orderly, folding have often, be with profit Main, defaecation is not hindered just, and qi-restoratives does not love heresy, and to treating both manifestation and root cause of disease, constipation must disappear.
Chinese angelica blood supplementing promoting blood circulation, moisturize laxation, Herba Cistanches kidney-replenishing, benefiting essence-blood relax bowel in the Chinese prescription of the present invention, The two is monarch drug in a prescription, kidney-replenishing blood-nourishing, reinvigoration altogether；Pueraria lobata rising Yang, matrimony vine are supporing yang, and drug effect is improved after the two compatibility, Outside principal drug assistance tonifying kidney and nourishing liver, can Yin Yang balancing, the gas of tonifying five zang organs；Rheum officinale purges heat logical intestines, pueraria lobata Shengyang Zhixie, and one rushes down and stops, and makes There is section under rushing down；Rhizoma Atractylodis Macrocephalae, Poria cocos, root of Aucklandia lappa Decne match, and energy enriching yin supports Tianjin, strengthening the spleen and replenishing qi, improves a poor appetite, and gain monarch drug in a prescription does not reach, this five Person is ministerial drug, tonify deficiency benefit health, strengthening spleen and nourishing stomach；Corydalis tuber helps Radix Angelicae Sinensis to invigorate blood circulation, and matches Rhizoma Atractylodis Macrocephalae qi-regulating, rhizoma anemarrhenae, Poria cocos, full Snakegourd Fruit enter lung Through fluid dryness, the wide chest of sharp gas, field pennycress, rice bean flower are clearing heat and detoxicating, are altogether adjutant, clearing heat and moistening lung；Licorice coordinating the drug actions of a prescription To make medicine；The benefits of cold temperature collocation of drug, rushes down receipts and is used in combination, and kidney-replenishing blood-nourishing, strengthening the spleen and replenishing qi, nourishing Yin and moistening lung, clearing heat and promoting fluid are played altogether by full side.
Oligofructose, xylo-oligosaccharide, stachyose used in the present invention not only can serve as sweetener instead of sucrose, and mouthfeel is more clear Refreshing, oligofructose has the adipose fragrance of class and tasty and refreshing soapy feeling, and can adjust the mouthfeel of oral solution, moreover it is possible to improve Microbial population ratio in enteron aisle.The molecular structure of each oligosaccharide is different, and the beneficial bacterium strain of proliferation is also different, this is this The major reason that invention is combined using a variety of oligosaccharide.Oligofructose is enteral bifidobacterium breve, bifidobacterium longum, baby's bifid Bacillus, bifidobacterium adolescentis, lactobacillus acidophilus, Lactobacillus salivarius the activation and proliferation factor, can reduce and inhibit enteral putrefaction The generation of matter inhibits the growth of harmful bacteria, adjusts enteron aisle inner equilibrium；It is preferential that xylo-oligosaccharide can be directly entered big enteral after taking It is utilized by bifidobacterium longum, bifidobacterium adolescentis, Lactobacillus salivarius, beneficial bacterium is promoted to generate a variety of organic acids simultaneously, reduced Gut pH inhibits harmful bacteria growth；Stachyose can be proliferated intestinal bifidobacteria and lactic acid bacteria with 40 times of increasing velocities, inhibit production The generation of the spoilage organisms such as the sour clostridium of gas production, checks spoilage product generation, inhibits endogenous carcinogenic generation and absorption, And decomposite Multiple immunizations function factor.
Inulin also has enhancing gastrointestinal motility, improves in addition to having effects that oligosaccharide and adjusting intestinal microflora Functions of intestines and stomach, the effect of promoting digestion and increase appetite, improve immunity of organisms.
Honey energy oral liquid for adjusting sugariness in side, improves the mouthfeel of oral solution, moreover it is possible to cooperate with, play with remaining traditional Chinese medicinal components The effect of bowl spares is moisturized, analgesic, removing toxic substances alleviates dry constipation of intestines.
Passed through when being included into the heart, liver, lung three, fragrance can with promoting the circulation of qi, it is sweet in flavor can with emergency, Chinese Angelica blood replonishing and blood, with the body of tonifying liver, There is promoting blood circulation to adjust then tonifying Qi in the Qi-tonifying drug that enters of work(of blood again, then enrich blood in the antianaemics entered, compatibility Herba Cistanches, can kidney-replenishing blood-nourishing, Keep internal Tianjin blood full, moisturizes logical intestines；Compatibility Rhizoma Atractylodis Macrocephalae, Poria cocos, invigorating the spleen green blood.
Matrimony vine is sweet in flavor, mild-natured, Return liver, kidney, lung channel, and nourishing the liver, nourshing kidney, moistening lung are supporing yang, compatibility Herba Cistanches nourishing kidney-YIN；Match Kidney, strengthen immunity are supported in 5 pueraria lobatas, YIN and YANG balance regulating, liver protection.
Rheum officinale can not only purge heat logical intestines, can also match Radix Angelicae Sinensis dispelling stasis of blood and stimulating the menstrual flow, improve anal intestine, pelvic diaphragm muscle and nerve conduction work( Energy；With rhizoma anemarrhenae, field pennycress, rice bean flower removing pattogenic heat from the blood and toxic material from the body, enterotoxin is expelled.
Rhizoma Atractylodis Macrocephalae bitter, sweet, warm, returns spleen, stomach have effects that air making-up and spleen enlivening, eliminate dampness and have diuretic effect, and Poria cocos slightly sweet flavor is flat, Such as the heart, lung, the spleen channel, have effects that eliminating dampness and diuresis, strengthening the spleen and stomach and antitoxic heart-soothing and sedative, root of Aucklandia lappa Decne have promoting qi circulation and relieving pain, reinforcing spleen to promote digestion Function, three's compatibility, can facilitaing lung invigorating the spleen, promote stomach, improve a poor appetite.
Corydalis tuber property and flavor of peppery and warm, bitter, Return liver, the spleen channel, can the stagnation of the circulation of vital energy in promoting circulation of blood, stasis in gas, Chinese medicine thinks：" bitterly then not It is logical, no pain by smooth breath ", whether blood is gas, and for product without dissipating person, taking this power can be sensible, warm-natured with its, then can manage it in qi and blood can be smooth, Acrid flavour, which can then moisten in qi and blood, to be dissipated, and compatibility Radix Angelicae Sinensis, Herba Cistanches, pueraria lobata, matrimony vine increase the justice for supporting battalion, and compatibility Rhizoma Atractylodis Macrocephalae, Poria cocos, root of Aucklandia lappa Decne add The feelings of QI invigorating, it is solidifying by stagnant to attack, make up and down qi and blood a surname reach.
Poria cocos slightly sweet flavor is flat, such as the heart, lung, the spleen channel, has effects that eliminating dampness and diuresis, strengthening the spleen and stomach and antitoxic heart-soothing and sedative, matches Rhizoma Atractylodis Macrocephalae, rhizoma anemarrhenae bitter, sweet, cold in nature, distributed in lung channel, stomach, kidney channel, clearing heat-fire, fluid dryness, full Snakegourd Fruit, clearing away heat and eliminating phlegm, wide chest Dissipating bind, moisturize laxation, four medicine compatibilities, mutual reinforcement between are to use, and mend earth generating metal, moistening lung qi-regulating, lung qi and then mechanism of qi is unobstructed, the five internal organs could just Often activity, and the lung and the large intestine being interior-exteriorly related, lung qi, which is declared, to be sent out respectful and drops normally, then large intestine conduction is smooth, and it is unfavorable that large intestine on the contrary conducts, then lung It loses a surname and send out respectful drop, this is " treating the upper part for diseases of the lower part ".
Field pennycress enters stomach, large intestine, Liver Channel, promotes the blood circulation of large intestine inner membrance, promoting blood circulation with Radix Angelicae Sinensis, corydalis tuber, with red Jelly palm flower controls accumulated heat in intestines, blood under hemorrhoid impotence, and the two is clearing heat and detoxicating, can remuval of damp and hot cult poison, accelerate metabolism.Red bean little Hua is at this Poria cocos inducing diuresis for removing edema can also be matched in side, promote the production of body fluid with rhizoma anemarrhenae, help digestion with root of Aucklandia lappa Decne, improve prescription overall efficacy.
Bowel relaxing oral liquid provided by the invention be under guidance of traditional Chinese medicine theory, in conjunction with a large amount of modern sciences practice and Research obtains, and can promote intestines peristalsis, improves intestinal environment, reduces toxin accumulation, can invigorating the kidney and spleen, clearing heat and moistening lung, make The smooth blood of gas is living, body fluid is full, internal organs transporting degree of having, and enhances contraction of muscle ability, improves the feeling kinetic energy of rectum, improves Pelvic floor The excitability of meat, keeps defecation power sufficient, has apparent therapeutic effect to constipation and multiple complications, moreover it is possible to improve constipation trouble The immune function and physical function of person reduces recurrence probability.
Each raw material pharmacology is as follows in Chinese medicine preparation of the present invention：
Honey：It is sweet in flavor, it is mild-natured；Return lung, spleen, large intestine channel；Bowl spares is moisturized, and is relieved pain, removing toxic substances.For the empty pain of gastral cavity abdomen, the dryness of the lung is dry Cough, dry constipation of intestines；It controls sore outside not hold back, scald.
Radix Angelicae Sinensis：It is sweet in flavor, pungent, it is warm-natured；Return liver, the heart, the spleen channel.Replenishing and activating blood, menstruction regulating and pain relieving relax bowel.It withers for the deficiency of blood Huang, dizziness palpitaition, irregular menstruation, closed dysmenorrhea, asthenia cold abdominalgia, dry constipation of intestines, arthralgia pain due to rheumatism injury from falling down, ulcer sores.
Herba Cistanches：It is sweet in flavor, salty, it is warm-natured；Return kidney, large intestine channel.Kidney-replenishing, benefiting essence-blood relax bowel.It is infertile for impotence, Soreness and weakness of waist and knees, muscles and bones is powerless, dry constipation of intestines.
Matrimony vine：It is sweet in flavor, mild-natured；Return liver and kidney channel；It is nourishing liver and kidney, benefiting shrewd head.For consumption consumptive loss, soreness of waist and knee joint, dizziness Tinnitus, Heat Diabetes, blood deficiency chlorosis, blurred vision.Amino acid and glycine betaine in containing 14 in the fruit of Chinese wolfberry, provitamin A (Hu Luo Blood can drop in Bu Su), zeaxanthin, niacin, vitamin B1, B2, C, phosphorus, calcium, iron, organic germanium, physalin and linoleic acid etc. It is pressure, reducing fat, hypoglycemic, inhibit fatty liver and antitumor etc..Chinese medicine thinks its flat property and sweet taste, can nourishing yin and supplementing the kidney improving eyesight.
Pueraria lobata：It is sweet in flavor, pungent, it is mild-natured；Returns spleen, stomach.Expelling pathogenic factors from muscles and skin is brought down a fever, and is promoted the production of body fluid, promoting eruption, Shengyang Zhixie.For fever caused by exogenous pathogens Headache, stiff nape and back, it is thirsty, it quenches one's thirst, measles without adequate eruption, hot dysentery, diarrhea；Hypertension neck pain.Energy sending up the lucid yang, inspires taste Yang-energy rises, and plays the role of preventing diarrhea, the treatment splenasthenic diarrheas such as clinical often cooperation Radix Codonopsis, Rhizoma Atractylodis Macrocephalae；But the coptis, radix scutellariae can be matched Deng for diseases such as damp-heat dysenteries.
Rheum officinale：Bitter, it is cold in nature；Returns spleen, stomach, large intestine, pericardium, Liver Channel.Purge heat logical intestines, removing pattogenic heat from the blood and toxic material from the body, dispelling stasis of blood and stimulating the menstrual flow.With In：Real heat constipation, stagnate abdominal pain, and rush down dysentery is not well, damp and hot yellow subcutaneous ulcer, blood-head tells nosebleed, hot eyes, pharynx swelling, abdominalgia with intestinal abscess, carbuncle swells furunculosis, Blood stasis closed, injury from falling down control scald outside；Upper gastrointestinal bleeding.
Rhizoma Atractylodis Macrocephalae：It is sweet in flavor, bitter, slightly warm in nature；Returns spleen, stomach.Tonifying middle-Jiao and Qi, strengthening the spleen and stomach, eliminate dampness and have diuretic effect, antiemetic rush down, hidroschesis, Tocolysis.It is weak for the middle deficiency of vital energy, indigestion caused by dysfunction of the spleen, oedema turgor, vomiting dysentery, fetal irritability, physically weak spontaneous perspiration Equal diseases.Contain volatile oil about 1.5% in Rhizoma Atractylodis Macrocephalae, main component is atractylone, atractylol etc..Another active component of Rhizoma Atractylodis Macrocephalae is Lactone compound.For Rhizoma Atractylodis Macrocephalae after stir-bake to brown, soil are fried, bran is fried, volatile oil about loses 15%, to reach mitigation " dry property ", subtract Few irritating processing purpose to stomach and intestine, while also playing the role of fragrant spleen benefiting and stimulating the appetite.
Corydalis tuber：Acrid flavour temperature, bitter, Return liver, the spleen channel；Promoting blood circulation, sharp gas, analgesic.For chest side of body, epigastric pain, Amenorrhea pain Through, postpartum stasis, tumbling and swelling.《Medicine origin》:Control taste it is depressed it is stagnant do not dissipate, main consumptive disease is cold to rush down, pain in the chest and abdomen, and lower gas helps digestion.
Poria cocos：It is sweet in flavor, light, it is mild-natured；The thoughts of returning home, lung, spleen, kidney channel.Clearing damp and promoting diuresis, invigorating the spleen calming heart.For oedema oliguria, phlegm and retained fluid Feel dizzy and heart palpitations, spleen eating less, loose stool diarrhea, confused and worried, insomnia of palpitating with fear.
Root of Aucklandia lappa Decne：Acrid flavour, hardship, it is warm-natured；Converge to the spleen channel, stomach, large intestine, gallbladder channel.With promoting qi circulation and relieving pain, the function of reinforcing spleen to promote digestion. For losing the appetite, accumulation of food in the stomach and intes tine due to indigestion, abdominal distention, increased borborygmus and diarrhea, tenesmus or distending pain in hypochondrium etc..Roasted RADIX AUCKLANDIAE removes part Oil enhances the effect of real intestines antidiarrheal, is chiefly used in splenasthenic diarrhea, borborygmus abdominal pain etc..With Rhizoma Atractylodis Macrocephalae, Poria cocos with using, stop with invigorating the spleen The effect rushed down loses fortune, diarrhea with loose stool for spleen deficiency, and abdominal distension secret anguish receives the cards such as poor gastral cavity ruffian；With pueraria lobata with using, it is used for diarrhea due to damp-heat, Rush down the dilute water of lower yellow, the cards such as burning sensation of the anus.
Full Snakegourd Fruit:It is sweet in flavor, it is cold in nature；Return lung, stomach, large intestine channel.Clearing lung and eliminating phlegm, the sharp wide chest of gas；Moistening lung for removing phlegm, laxation defaecation, Mass dissipating and swelling eliminating.For phlegm-heat cough, the obstruction of qi in the chest, accumulation of pathogens in chest, chest diaphragm ruffian pain, dry constipation of intestines, lung carbuncle, acute mastitis.With anti-aging effects, resist Pathogenic microorganism effect improves cardiovascular function, anti-ulcer effect, expelling phlegm and arresting coughing effect.
Rhizoma anemarrhenae：It is bitter, sweet, it is cold in nature.Distributed in lung channel, stomach, kidney channel.With clearing heat-fire, the function of fluid dryness.For outer Sensible heat disease, hyperpyrexia polydipsia, lung-heat type cough, hectic fever due to yin labor heat, Heat Diabetes, dry constipation of intestines etc..The Qing Dynasty《Herbal lease making》Record rhizoma anemarrhenae " moisturizing enriching yin, profit two is just ".Rhizoma anemarrhenae has both sugariness, sweet cold yin-nourishing, the heat-clearing not anti-enriching yin of impairment of yin simultaneously, Chinese medicine preparation scientific principle simultaneously By think after rhizoma anemarrhenae salt system can priming downlink enter kidney channel, nourishing yin and lessening fire effect enhancing, therefore treat lung-heat type cough, osteopyrexia and fever, Salt product is mostly used when Heat Diabetes, dry constipation of intestines.
Field pennycress：Acrid flavour, hardship, it is cool in nature；Enter stomach, large intestine, Liver Channel.It is clearing heat and detoxicating, the carbuncle that disappears apocenosis, blood circulation promoting competent silt.For intestines Carbuncle, lung carbuncle and sore and toxic, the chest and abdomen pain caused by the real heat stasis of blood is stagnant, the diseases such as postpartum stasis of blood.
Rice bean flower：Acrid flavour, slightly cool in nature；The thoughts of returning home, spleen, stomach, large intestine channel.Heat-clearing is quenched the thirst, and is sobered up, removing toxic substances.Preventing and curing malaria disease, dysentery Disease is quenched one's thirst, and liver heat, hot eyes is dim-sighted, abdominal distention and little diet, headache due to excessive drinking, blood under hemorrhoid complicated by anal fistula, erysipelas, furunculosis.
Radix Glycyrrhizae：It is sweet in flavor, it is mild-natured；The thoughts of returning home, lung, spleen, stomach.It invigorates the spleen and benefits qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain is adjusted With all medicines.For weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity abdomen, four limbs contraction, carbuncle sore tumefacting virus, delay Solve drug toxicity, strong.
Bowel relaxing oral liquid provided by the invention and preparation method thereof has below compared with prior art beneficial to effect Fruit：
1. the method that bowel relaxing oral liquid provided by the invention abandons conventional therapy constipation " based on rushing down ", by middle medical knowledge It is combined by with modern science, traditional Chinese medicine extracting solution and new type functional sugar source is compounded, acted synergistically between each component, promoted The performance of drug effect, can enriching yin and nourishing kidney, tonify deficiency benefit health, strengthening spleen and nourishing stomach, clearing heat and moistening lung and promote intestines peristalsis, promote the production of body fluid, it is not only right Constipation has apparent therapeutic effect, and simultaneous can control various constipation complication, improves the physical function of constipation patient；
2. bowel relaxing oral liquid preparation method provided by the invention, first carries out processing processing to Chinese medicine material, then adopts It is carried with ultrasonic method water, can fully extract the active ingredient in Chinese medicine material, promoted to interact between active ingredient, shorten extraction Time reduces energy consumption, then can remove most of impurity through alcohol precipitation without heating, moreover it is possible to the stability of oral solution is improved and enhances, And the addition of polysaccharide is optimized from quality control, products obtained therefrom clear, without layering and impurity, uniformly without heavy It forms sediment, smell faint scent is in good taste during hardship is comfortable；
3. bowel relaxing oral liquid provided by the invention, Component Source is wide, prepares simply, at low cost, clinical application shows Taking has significant curative effect, total effective rate 93.3% for one week.
Specific implementation mode
Further to illustrate the technological means and its effect of the invention taken, below in conjunction with the preferred implementation of the present invention Example is described in detail.
Embodiment 1
A kind of bowel relaxing oral liquid, contained component raw material and its parts by weight are：2 parts of oligofructose, xylo-oligosaccharide 0.5 Part, 0.5 part of stachyose, 2 parts of inulin, 5 parts of honey, 30 parts of Herba Cistanches, 25 parts of the fruit of Chinese wolfberry, 25 parts of pueraria lobata, 10 parts of rheum officinale, Rhizoma Atractylodis Macrocephalae 25,15 parts of Radix Angelicae Sinensis, 20 parts of Poria cocos, 8 parts of corydalis tuber, 5 parts of root of Aucklandia lappa Decne, 6 parts of rhizoma anemarrhenae, 5 parts of full Snakegourd Fruit, 5 parts of field pennycress, rice bean flower 5 Part, 4 parts of Radix Glycyrrhizae.
A kind of preparation method of bowel relaxing oral liquid, includes the following steps：
Step 1: bulk pharmaceutical chemicals are handled：The fruit of Chinese wolfberry cleans, cleans, it is spare to dry；Full Snakegourd Fruit, rice bean flower removal of impurities, clean, Drying in the shade, it is spare to smash to pieces；Herba Cistanches, rheum officinale, Radix Angelicae Sinensis, Poria cocos, Radix Glycyrrhizae removal of impurities, are cleaned, cut into serving pieces pueraria lobata；Bighead atractylodes rhizome piece bran is fried, and is fried It is in yellowish-brown to Rhizoma Atractylodis Macrocephalae, takes out, weed out wheat bran, cool spare；Corydalis tuber vinegar system dries in the air to sixty percent dry, cuts sheet, smashed to pieces after drying It is spare；Root of Aucklandia lappa Decne simmers system, cools, spare；Rhizoma anemarrhenae piece salt system, dries in the air cool, weeds out clast；Field pennycress removes impurity, sprays clear water, slightly Profit, segment are dried, and are fried to black with the slow fire of firewood, micro- watering is dried spare；
Step 2: traditional Chinese medicine extraction：By the processed each component of step 1, the clear water of 4 times of amounts is added to impregnate 1h, then 20kHz, 120W is ultrasonically treated 40min, filtering, and then 40kHz, 120W supersound process 20min, filtering filtrate will merge twice, and decompression is dense The liquid of relative density 1.2 when being reduced to 60 DEG C, stands cooling and takes supernatant, add ethyl alcohol, stand 24 hours, and filtrate is recycled in filtering Middle ethyl alcohol is to get the concentrated liquid of tradition Chinese medicine；
Step 3: allotment, homogeneous：The oligomeric fruit of corresponding parts by weight is added in the concentrated liquid of tradition Chinese medicine obtained to step 1 Sugar, xylo-oligosaccharide, stachyose, inulin, honey, add water to stir, homogeneous under the conditions of 40 DEG C of temperature, pressure 25MPa；
Step 4: packing, sterilizing：Mixed liquor after homogeneous is subjected to filling, sterilizing, thus obtaining the product product.
Preferably, add ethyl alcohol to alcohol content 70% in step 2.
Embodiment 2
A kind of bowel relaxing oral liquid, contained component raw material and its parts by weight are：3 parts of oligofructose, xylo-oligosaccharide 0.6 Part, 1.0 parts of stachyose, 3 parts of inulin, 6 parts of honey, 32 parts of Herba Cistanches, 26 parts of the fruit of Chinese wolfberry, 28 parts of pueraria lobata, 12 parts of rheum officinale, Rhizoma Atractylodis Macrocephalae 26,16 parts of Radix Angelicae Sinensis, 22 parts of Poria cocos, 9 parts of corydalis tuber, 6 parts of root of Aucklandia lappa Decne, 7 parts of rhizoma anemarrhenae, 6 parts of full Snakegourd Fruit, 5.5 parts of field pennycress, rice bean flower 5.5 parts, 4.5 parts of Radix Glycyrrhizae.
A kind of preparation method of bowel relaxing oral liquid, includes the following steps：
Step 1: bulk pharmaceutical chemicals are handled：The fruit of Chinese wolfberry cleans, cleans, it is spare to dry；Full Snakegourd Fruit, rice bean flower removal of impurities, clean, Drying in the shade, it is spare to smash to pieces；Herba Cistanches, rheum officinale, Radix Angelicae Sinensis, Poria cocos, Radix Glycyrrhizae removal of impurities, are cleaned, cut into serving pieces pueraria lobata；Bighead atractylodes rhizome piece bran is fried, and is fried It is in yellowish-brown to Rhizoma Atractylodis Macrocephalae, takes out, weed out wheat bran, cool spare；Corydalis tuber vinegar system dries in the air to sixty percent dry, cuts sheet, smashed to pieces after drying It is spare；Root of Aucklandia lappa Decne simmers system, cools, spare；Rhizoma anemarrhenae piece salt system, dries in the air cool, weeds out clast；Field pennycress removes impurity, sprays clear water, slightly Profit, segment are dried, and are fried to black with the slow fire of firewood, micro- watering is dried spare；
Step 2: traditional Chinese medicine extraction：By the processed each component of step 1, the clear water of 4 times of amounts is added to impregnate 1.2h, then 20kHz, 120W are ultrasonically treated 40min, filtering, and then 40kHz, 120W supersound process 20min, filtering filtrate will merge twice, The liquid of relative density 1.2 when being concentrated under reduced pressure into 60 DEG C stands cooling and takes supernatant, add ethyl alcohol, stand 24 hours, filter, returns Ethyl alcohol is to get the concentrated liquid of tradition Chinese medicine in receipts filtrate；
Step 3: allotment, homogeneous：The oligomeric fruit of corresponding parts by weight is added in the concentrated liquid of tradition Chinese medicine obtained to step 1 Sugar, xylo-oligosaccharide, stachyose, inulin, honey, add water to stir, homogeneous under the conditions of 42 DEG C of temperature, pressure 30MPa；
Step 4: packing, sterilizing：Mixed liquor after homogeneous is subjected to filling, sterilizing, thus obtaining the product product.
Preferably, add ethyl alcohol to alcohol content 70% in step 2.
Embodiment 3
A kind of bowel relaxing oral liquid, contained component raw material and its parts by weight are：4 parts of oligofructose, xylo-oligosaccharide 0.7 Part, 1.5 parts of stachyose, 4 parts of inulin, 8 parts of honey, 40 parts of Herba Cistanches, 28 parts of the fruit of Chinese wolfberry, 32 parts of pueraria lobata, 14 parts of rheum officinale, Rhizoma Atractylodis Macrocephalae 29,22 parts of Radix Angelicae Sinensis, 27 parts of Poria cocos, 14 parts of corydalis tuber, 8 parts of root of Aucklandia lappa Decne, 8 parts of rhizoma anemarrhenae, 8 parts of full Snakegourd Fruit, 6.5 parts of field pennycress, rde bean Spend 6.5 parts, 5 parts of Radix Glycyrrhizae.
A kind of preparation method of bowel relaxing oral liquid, includes the following steps：
Step 1: bulk pharmaceutical chemicals are handled：The fruit of Chinese wolfberry cleans, cleans, it is spare to dry；Full Snakegourd Fruit, rice bean flower removal of impurities, clean, Drying in the shade, it is spare to smash to pieces；Herba Cistanches, rheum officinale, Radix Angelicae Sinensis, Poria cocos, Radix Glycyrrhizae removal of impurities, are cleaned, cut into serving pieces pueraria lobata；Bighead atractylodes rhizome piece bran is fried, and is fried It is in yellowish-brown to Rhizoma Atractylodis Macrocephalae, takes out, weed out wheat bran, cool spare；Corydalis tuber vinegar system dries in the air to sixty percent dry, cuts sheet, smashed to pieces after drying It is spare；Root of Aucklandia lappa Decne simmers system, cools, spare；Rhizoma anemarrhenae piece salt system, dries in the air cool, weeds out clast；Field pennycress removes impurity, sprays clear water, slightly Profit, segment are dried, and are fried to black with the slow fire of firewood, micro- watering is dried spare；
Step 2: traditional Chinese medicine extraction：By the processed each component of step 1, the clear water of 4 times of amounts is added to impregnate 1.6h, then 20kHz, 120W are ultrasonically treated 40min, filtering, and then 40kHz, 120W supersound process 20min, filtering filtrate will merge twice, The liquid of relative density 1.2 when being concentrated under reduced pressure into 60 DEG C stands cooling and takes supernatant, add ethyl alcohol, stand 24 hours, filter, returns Ethyl alcohol is to get the concentrated liquid of tradition Chinese medicine in receipts filtrate；
Step 3: allotment, homogeneous：The oligomeric fruit of corresponding parts by weight is added in the concentrated liquid of tradition Chinese medicine obtained to step 1 Sugar, xylo-oligosaccharide, stachyose, inulin, honey, add water to stir, homogeneous under the conditions of 40~50 DEG C of temperature, pressure 35MPa；
Step 4: packing, sterilizing：Mixed liquor after homogeneous is subjected to filling, sterilizing, thus obtaining the product product.
Preferably, add ethyl alcohol to alcohol content 70% in step 2.
Embodiment 4
A kind of bowel relaxing oral liquid, contained component raw material and its parts by weight are：5 parts of oligofructose, xylo-oligosaccharide 0.9 Part, 2.5 parts of stachyose, 5 parts of inulin, 9 parts of honey, 45 parts of Herba Cistanches, 30 parts of the fruit of Chinese wolfberry, 35 parts of pueraria lobata, 15 parts of rheum officinale, Rhizoma Atractylodis Macrocephalae 30,25 parts of Radix Angelicae Sinensis, 28 parts of Poria cocos, 16 parts of corydalis tuber, 9 parts of root of Aucklandia lappa Decne, 10 parts of rhizoma anemarrhenae, 9 parts of full Snakegourd Fruit, 7 parts of field pennycress, rice bean flower 7 parts, 6 parts of Radix Glycyrrhizae.
A kind of preparation method of bowel relaxing oral liquid, includes the following steps：
Step 1: bulk pharmaceutical chemicals are handled：The fruit of Chinese wolfberry cleans, cleans, it is spare to dry；Full Snakegourd Fruit, rice bean flower removal of impurities, clean, Drying in the shade, it is spare to smash to pieces；Herba Cistanches, rheum officinale, Radix Angelicae Sinensis, Poria cocos, Radix Glycyrrhizae removal of impurities, are cleaned, cut into serving pieces pueraria lobata；Bighead atractylodes rhizome piece bran is fried, and is fried It is in yellowish-brown to Rhizoma Atractylodis Macrocephalae, takes out, weed out wheat bran, cool spare；Corydalis tuber vinegar system dries in the air to sixty percent dry, cuts sheet, smashed to pieces after drying It is spare；Root of Aucklandia lappa Decne simmers system, cools, spare；Rhizoma anemarrhenae piece salt system, dries in the air cool, weeds out clast；Field pennycress removes impurity, sprays clear water, slightly Profit, segment are dried, and are fried to black with the slow fire of firewood, micro- watering is dried spare；
Step 2: traditional Chinese medicine extraction：By the processed each component of step 1, the clear water of 4 times of amounts is added to impregnate 2h, then 20kHz, 120W is ultrasonically treated 40min, filtering, and then 40kHz, 120W supersound process 20min, filtering filtrate will merge twice, and decompression is dense The liquid of relative density 1.2 when being reduced to 60 DEG C, stands cooling and takes supernatant, add ethyl alcohol, stand 24 hours, and filtrate is recycled in filtering Middle ethyl alcohol is to get the concentrated liquid of tradition Chinese medicine；
Step 3: allotment, homogeneous：The oligomeric fruit of corresponding parts by weight is added in the concentrated liquid of tradition Chinese medicine obtained to step 1 Sugar, xylo-oligosaccharide, stachyose, inulin, honey, add water to stir, homogeneous under the conditions of temperature 50 C, pressure 40MPa；
Step 4: packing, sterilizing：Mixed liquor after homogeneous is subjected to filling, sterilizing, thus obtaining the product product.
Preferably, add ethyl alcohol to alcohol content 70% in step 2.
Comparative example 1
Comparative example 1 and the technical solution of embodiment 3 are essentially identical, the difference is that without Fructooligosaccharides, xylo-oligosaccharide, Stachyose, inulin component.
Comparative example 2
Comparative example 2 and the technical solution of embodiment 3 are essentially identical, the difference is that being free of the concentrated liquid of tradition Chinese medicine.
Comparative example 3
Comparative example 3 and the technical solution of embodiment 3 are essentially identical, the difference is that in traditional Chinese medicinal components without Radix Angelicae Sinensis, Herba Cistanches.
Comparative example 4
Comparative example 3 and the technical solution of embodiment 3 are essentially identical, prolong recklessly the difference is that being free of in traditional Chinese medicinal components Rope.
The ease constipation that above example, comparative example are prepared in terms of animal experiment and clinical application two separately below Defaecation oral solution is analyzed.
Animal experiment
1. intestinal motility is tested
Experiment grouping and dosage：ICR male mices 176 are taken, 11 groups, i.e. blank control group, model are randomly divided into Control group, positive controls are test group 1, test group 2, test group 3, test group 4, contrast groups 1, contrast groups 2, contrast groups 3, right Than group 4.Every group 16, each 8 points of cages are fed.Each group gives basal feed, and blank control group, model control group are given once daily The physiological saline of capacity, positive controls fill Maren wan test solution (pressing the daily 12g recommended doses of people), examination with identical capacity daily Test group and contrast groups daily respectively the test solution with identical capacity containing corresponding oral solution (by the daily 10mL recommended doses of people) to mouse Give tested material gavage, continuous gavage 7d.
Modeling and testing index：After tested material 7d, each group mouse is deprived of food but not water 16h.Model control group, positive control Group, test group and contrast groups gavage give compound diphenoxylate (10mg/kg), and blank control group gives distilled water.After 0.5h, examination It tests group and contrast groups gives the prepared Chinese ink (containing 5% activated carbon, 10% arabia gum) containing corresponding tested oral solution respectively, it is positive Control group gives the prepared Chinese ink containing positive drug, blank control group and model control group and gives prepared Chinese ink gavage.It is 0.2mL/ that capacity, which is administered, 10g.Observe and record every rat arrange the black time for the first time, defecation grain number and quality in 5h, calculate excrement water content and defaecation accelerate Rate.
Grouping and drug dose, modeling method are same as above, and cervical dislocation immediately is administered after 25min and puts to death mouse, opening abdominal cavity point From mesenterium, clip upper end from pylorus, the intestinal tube of lower end to ileocecus, measurement Length of intestine be total small intestinal length, from pylorus to Prepared Chinese ink forward position is that prepared Chinese ink promotes length, calculates ink progradation：
Ink progradation/%=prepared Chinese ink promotes length (cm)/total small intestinal length (cm) × 100.
Statistical method：Test data withIt indicates, one-way analysis of variance is carried out using 17.0 statistical softwares of SPSS.
Interpretation of result：Statistical result is shown in Table 1.
The influence of 1~4 pair of Constipation Model rat defecation of 1 Examples 1 to 4 of table and comparative example
Note：Defecation time is compared with blank group for the first time, and compared with model group, * is significant difference P for other<0.05；* is The extremely notable P of difference<0.01, * * * are difference highly significant P<0.001.
As shown in Table 1, defecation grain number and excrement water content, prepared Chinese ink promote the time required to model group arranges melena for the first time, in 5h Rate and the extremely notable P of blank group difference<0.01, illustrate Constipation Model success.Each index is the result shows that positive controls, each test group To small mouse's head, just there is shortening effect in the time with control group, or has increased effect to feces volume, excrement water content.Test group all compares Positive group is short, and all statistically significant (P<0.05), contrast groups and positive group difference are little.It is to refer to mouse 5h defecation grain numbers Mark, each test group of row's melena grain number are highly higher than model control group (P<0.001), control group is significantly higher than positive group.Experiment Group 1~4 is compared with model group, and ink progradation is higher, and the statistically significant (P of difference<0.01).1~4 prepared Chinese ink of contrast groups pushes away It is higher than model group, and the statistically significant (P of difference into rate<0.05), but it is significantly lower than test group.
It is obviously promoted intestinal motility, the row of raising from oral liquid energy provided by the invention known to the analysis of above-mentioned results of animal Just amount and excrement water content, and control group and the difference on effect of test group show there is synergistic effect between each component.
2. swimming time is tested
Experiment grouping and dosage：ICR male mices 48 are taken, 6 groups, i.e. blank control group, model pair are randomly divided into According to group, positive controls, low dose group, middle dose group, high dose group, every group 8.Each group gives basal feed, model comparison Group, positive controls, each dosage group gavage give compound diphenoxylate (10mg/kg), and blank control group gives distilled water.10d The physiological saline for the capacity such as each group gives basal feed afterwards, and blank control group, model control group are given once daily, positive controls are every It fills Maren wan test solution (pressing the daily 12g recommended doses of people) with identical capacity, and each dosage group is pressed with identical capacity respectively daily Oral solution test solution made from embodiment 3 gives tested material gavage to mouse, and low dose group presses people by the daily 5mL of people, middle dose group Daily 10mL, high dose group dilute or are condensed into identical capacity, continuous gavage 7d by the daily 20mL of people.After the last administration by mouse It is put into 15 DEG C of water, record was put into the death time, the results are shown in Table 2.
Table 2 influences mouse swimming time
Group Dosage Swimming time/min
Blank control group __ 27.32±6.98
Model control group __ 18.76±7.01△
Positive controls __ 32.45±6.37*
Low dose group 5mL 30.62±7.49
Middle dose group 10mL 35.77±5.44*
High dose group 15mL 38.59±7.52*
Note：△For compared with blank group,△For significant difference P<0.05；△△For the extremely notable P of difference<0.01；* it is and model Group compares, and * is significant difference P<0.05；* is the extremely notable P of difference<0.01.
As known from Table 2, after 7d being administered, compared with naive mice swimming time, model group mouse swimming time obviously contracts It is short, P<0.05；Compared with model group, positive group, each dosage group swimming time extend, P<0.05, show the mouth that relaxes bowel The body activities time can be extended by taking liquid, and dosage is bigger, and the activity time is longer, show the increase with dosage, the body of mouse Function increases.
Clinical application
Choose constipation patient 149, man 72, female 77,24~69 years old age, averagely 43 years old；The infrequent defecation time 3~ It differs within 10 days；The course of disease is most 3 months short, longest 9 years, 3.4 years average.Organic cause is excluded, is simple constipation.149 Patient is divided into two groups on a voluntary basis, treatment group 75, control group 74, and the offer of the embodiment of the present invention 3 is given by treatment group Bowel relaxing oral liquid is treated, and once a day, each 10mL, control group uses Bisacody enteric coatel tablets, once a day, every time one Piece is taken two weeks.
Observation index：Defecation frequency, defecation degree of mobility, feeling, curative effect are held time after an action of the bowels.
Statistical analysis：It is for statistical analysis with SPSS17.0 statistical softwares, enumeration data Chi-square Test.
Efficacy assessment standard：Reference《New drug (Chinese medicine) treats constipation guideline of clinical investigations》It formulates.Clinical recovery：Row Just without discomfort, one time a day, soft stool is discharged, defecates after being discontinued 4 weeks still unobstructed；It is effective：After taking 1 course for the treatment of, times of defecation restores just Often, fecal character is normal, and defecation is unobstructed, no difficulty；Effectively：Reach 1~2 person in 3 listed by effective；In vain：Take 1 course for the treatment of Afterwards, symptom is not improved.
Interpretation of result：Analysis result is shown in Table 3, treatment group's clinical cure 21, effective 35, effective 14, total effective rate 93.3%；Control group clinical recovery 7, effective 22, effective 27, total effective rate 75.6%.Two groups of curative effects are relatively total more effective Rate there were significant differences (P<0.05) it is 74.7% that, treatment group, which cures with effective accounting, hence it is evident that cures more than control group and is accounted for effective Than 39.2%.
3 treatment group of table is compared with control group therapeutic effect
Group n It cures It is effective Effectively In vain Total effective rate (%)
Treatment group 75 21 35 14 7 93.3
Control group 74 7 22 27 18 72.2
Adverse reaction treatment group and control group adverse reaction situation, are shown in Table 4.It can see by table 4, treatment group's adverse reaction 2, incidence 2.7%；Adverse reaction 13, incidence 17.6% occur for control group.Two groups of adverse reaction rates pair Than there were significant differences (P<0.01).
3 two groups of adverse reaction situations of table
Group n Abdominal pain Abdominal distension Diarrhea Incidence (%)
Treatment group 75 0 2 0 2.7
Control group 74 4 6 3 17.6
To sum up, the present invention is compared with Bisacody enteric coatel tablets, and clinical treatment anti-constipation effect is more notable, and adverse reaction Incidence is low, and patient compliance is good.
Model case
Case 1：Korea Spro so-and-so, female, 29 years old, Hebei people from Handan, constipation half a year was more, abdominal distension, often has awareness of defecation but is difficult to be discharged, long Phase takes a variety of cathartics and causes abdominal pain, is recurred once cutting out cathartic, and it is every after 3 days to take bowel relaxing oral liquid of the present invention There is awareness of defecation smooth can be discharged, continue to take after a week, abdominal distension and colic symptoms disappear, and 03 months 1 year so far without recurrence.
Case 2：Mr. Li, male, 58 years old, Henan people from Shangqiu, prolonged constipation, dry and hard excrement, defecation time was long and with pain Pain, it is dizzy, it is listless, enema defecation is relied on always, takes bowel relaxing oral liquid of the present invention free movement of the bowels after a week, Feeling of pain disappears, and continues to take half a month constipation recovery from illness, dizziness mitigates, and energetic, seven months so far without recurrence.
Case 3：Mr. Wang, male, 62 years old, Nanyang, henan people, left leg was not nimble caused by apoplexy, and long-term wheelchair causes just Secret, each two weeks relies on bowel lavage and helps defecation, take bowel relaxing oral liquid of the present invention after 6 days can voluntarily defecation, one month Constipation is cured afterwards, and than before flexibly, effectively, ten months so far without recurrence for legs and feet.
Case 4：Slowly so-and-so, female, 35 years old, Heze City, Shandong Province people ate bubble face and causes just as food because staying up late for work for a long time Secret, fat, each defecation time is more than 40 minutes, and internal piles is caused to deviate from, and mood unhappiness, insomnia and dreamful sleep take ease constipation of the present invention Defecation time restores normal after defaecation oral solution 3 days, continues to take one week, constipation recovery from illness, internal piles return, weight loss, so far A year and a half is without recurrence.
The above description is merely a specific embodiment, but scope of protection of the present invention is not limited thereto, ability Other modifications or equivalent replacement that domain those of ordinary skill makes technical scheme of the present invention, without departing from skill of the present invention The spirit and scope of art scheme, are intended to be within the scope of the claims of the invention.

Claims (7)

1. a kind of bowel relaxing oral liquid, which is characterized in that contained component raw material and its parts by weight are：2 ~ 5 parts of oligofructose, 0.5 ~ 0.9 part of xylo-oligosaccharide, 0.5 ~ 2.5 part of stachyose, 2 ~ 5 parts of inulin, 5 ~ 9 parts of honey, 30 ~ 45 parts of Herba Cistanches, the fruit of Chinese wolfberry 25 ~ 30 parts, 25 ~ 35 parts of pueraria lobata, 10 ~ 15 parts of rheum officinale, Rhizoma Atractylodis Macrocephalae 25 ~ 30,15 ~ 25 parts of Radix Angelicae Sinensis, 20 ~ 28 parts of Poria cocos, 8 ~ 16 parts of corydalis tuber, 5 ~ 9 parts of root of Aucklandia lappa Decne, 6 ~ 10 parts of rhizoma anemarrhenae, 5 ~ 9 parts of full Snakegourd Fruit, 5 ~ 7 parts of field pennycress, 5 ~ 7 parts of rice bean flower, 4 ~ 6 parts of Radix Glycyrrhizae.
2. a kind of bowel relaxing oral liquid according to claim 1, which is characterized in that contained component raw material and its parts by weight Number is：2 parts of oligofructose, 0.5 part of xylo-oligosaccharide, 0.5 part of stachyose, 2 parts of inulin, 5 parts of honey, 30 parts of Herba Cistanches, the fruit of Chinese wolfberry 25 parts, it is 25 parts of pueraria lobata, 10 parts of rheum officinale, Rhizoma Atractylodis Macrocephalae 25,15 parts of Radix Angelicae Sinensis, 20 parts of Poria cocos, 8 parts of corydalis tuber, 5 parts of root of Aucklandia lappa Decne, 6 parts of rhizoma anemarrhenae, complete 5 parts of Snakegourd Fruit, 5 parts of field pennycress, 5 parts of rice bean flower, 4 parts of Radix Glycyrrhizae.
3. a kind of bowel relaxing oral liquid according to claim 1, which is characterized in that contained component raw material and its parts by weight Number is：3 parts of oligofructose, 0.6 part of xylo-oligosaccharide, 1.0 parts of stachyose, 3 parts of inulin, 6 parts of honey, 32 parts of Herba Cistanches, the fruit of Chinese wolfberry 26 parts, it is 28 parts of pueraria lobata, 12 parts of rheum officinale, Rhizoma Atractylodis Macrocephalae 26,16 parts of Radix Angelicae Sinensis, 22 parts of Poria cocos, 9 parts of corydalis tuber, 6 parts of root of Aucklandia lappa Decne, 7 parts of rhizoma anemarrhenae, complete 6 parts of Snakegourd Fruit, 5.5 parts of field pennycress, 5.5 parts of rice bean flower, 4.5 parts of Radix Glycyrrhizae.
4. a kind of bowel relaxing oral liquid according to claim 1, which is characterized in that contained component raw material and its parts by weight Number is：4 parts of oligofructose, 0.7 part of xylo-oligosaccharide, 1.5 parts of stachyose, 4 parts of inulin, 8 parts of honey, 40 parts of Herba Cistanches, the fruit of Chinese wolfberry 28 parts, it is 32 parts of pueraria lobata, 14 parts of rheum officinale, Rhizoma Atractylodis Macrocephalae 29,22 parts of Radix Angelicae Sinensis, 27 parts of Poria cocos, 14 parts of corydalis tuber, 8 parts of root of Aucklandia lappa Decne, 8 parts of rhizoma anemarrhenae, complete 8 parts of Snakegourd Fruit, 6.5 parts of field pennycress, 6.5 parts of rice bean flower, 5 parts of Radix Glycyrrhizae.
5. a kind of bowel relaxing oral liquid according to claim 1, which is characterized in that contained component raw material and its parts by weight Number is：5 parts of oligofructose, 0.9 part of xylo-oligosaccharide, 2.5 parts of stachyose, 5 parts of inulin, 9 parts of honey, 45 parts of Herba Cistanches, the fruit of Chinese wolfberry 30 parts, 35 parts of pueraria lobata, 15 parts of rheum officinale, Rhizoma Atractylodis Macrocephalae 30,25 parts of Radix Angelicae Sinensis, 28 parts of Poria cocos, 16 parts of corydalis tuber, 9 parts of root of Aucklandia lappa Decne, 10 parts of rhizoma anemarrhenae, Complete 9 parts of Snakegourd Fruit, 7 parts of field pennycress, 7 parts of rice bean flower, 6 parts of Radix Glycyrrhizae.
6. a kind of preparation method according to any bowel relaxing oral liquid of claim 1 ~ 5, which is characterized in that including following Step：
Step 1: bulk pharmaceutical chemicals are handled：The fruit of Chinese wolfberry cleans, cleans, it is spare to dry；Full Snakegourd Fruit, rice bean flower clean, clean, dry in the shade It smashs to pieces spare；Herba Cistanches, Radix Angelicae Sinensis, Poria cocos, Radix Glycyrrhizae removal of impurities, are cleaned, cut into serving pieces pueraria lobata；Bighead atractylodes rhizome piece bran is fried, and is fried to Rhizoma Atractylodis Macrocephalae in Huang Brown is taken out, weeds out wheat bran, cool spare；Corydalis tuber vinegar system dries in the air to sixty percent dry, cuts sheet, smashed to pieces after drying spare；Root of Aucklandia lappa Decne System is simmered, is cooled, it is spare；Rhizoma anemarrhenae piece salt system, dries in the air cool, weeds out clast；Field pennycress removes impurity, sprays clear water, slightly moistens, segment, shines It is dry, it is fried to black with the slow fire of firewood, micro- watering is dried spare；
Step 2: traditional Chinese medicine extraction：By the processed each component of step 1, the clear water of 4 times of amounts is added to impregnate 1 ~ 2 h, then 20 kHz, 120 W are ultrasonically treated 40 min, filtering, and then 40 kHz, 120 W, 20 min of supersound process, filtering filtrate will merge twice, The liquid of relative density 1.2 when being concentrated under reduced pressure into 60 DEG C stands cooling and takes supernatant, add ethyl alcohol, stand 24 hours, filter, returns Ethyl alcohol is to get the concentrated liquid of tradition Chinese medicine in receipts filtrate；
Step 3: allotment, homogeneous：The oligofructose, low of corresponding parts by weight is added in the concentrated liquid of tradition Chinese medicine obtained to step 1 Xylan, stachyose, inulin, honey, add water to stir, homogeneous under the conditions of 40 ~ 50 DEG C of temperature, 25 ~ 40 MPa of pressure；
Step 4: packing, sterilizing：Mixed liquor after homogeneous is subjected to filling, sterilizing, thus obtaining the product product.
7. the preparation method of bowel relaxing oral liquid according to claim 6, which is characterized in that in step 2 plus ethyl alcohol is to containing Alcohol amount 70%.
CN201810943118.6A 2018-08-17 2018-08-17 A kind of bowel relaxing oral liquid and preparation method Pending CN108771658A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810943118.6A CN108771658A (en) 2018-08-17 2018-08-17 A kind of bowel relaxing oral liquid and preparation method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201810943118.6A CN108771658A (en) 2018-08-17 2018-08-17 A kind of bowel relaxing oral liquid and preparation method

Publications (1)

Publication Number Publication Date
CN108771658A true CN108771658A (en) 2018-11-09

Family

ID=64028817

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201810943118.6A Pending CN108771658A (en) 2018-08-17 2018-08-17 A kind of bowel relaxing oral liquid and preparation method

Country Status (1)

Country Link
CN (1) CN108771658A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109998068A (en) * 2019-04-04 2019-07-12 北京紫云英保健品开发有限责任公司 A kind of preparation process of relax bowel and defecation honey

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1748768A (en) * 2004-09-17 2006-03-22 杜正东 Chinese patented medicine for catharsis and toxin expelling face nourishing and beauty
CN101103811A (en) * 2007-08-09 2008-01-16 修正药业集团股份有限公司 Health food capable of relaxing the bowels
CN105456341A (en) * 2014-09-28 2016-04-06 张秋云 Decoction for treating infant constipation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1748768A (en) * 2004-09-17 2006-03-22 杜正东 Chinese patented medicine for catharsis and toxin expelling face nourishing and beauty
CN101103811A (en) * 2007-08-09 2008-01-16 修正药业集团股份有限公司 Health food capable of relaxing the bowels
CN105456341A (en) * 2014-09-28 2016-04-06 张秋云 Decoction for treating infant constipation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
孟景春: "白术为治气虚便秘专药", 《江苏中医》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109998068A (en) * 2019-04-04 2019-07-12 北京紫云英保健品开发有限责任公司 A kind of preparation process of relax bowel and defecation honey

Similar Documents

Publication Publication Date Title
CN102048933B (en) Chinese medicinal composition for treating infantile diarrhea and preparation method thereof
CN103432475B (en) Traditional Chinese medicine composition for treating allergic rhinitis and preparation method thereof
CN103690919A (en) Medicine for treating piglet iron-deficiency anemia and preparation method of medicine
CN104840935B (en) Prevent and treat Chinese herbs paste of grice diarrhoea and its preparation method and application
CN103977372A (en) Traditional Chinese medicine additive used for treating porcine epizootic diarrhea and preparing method thereof
CN103920027A (en) Medicament for treating acute jaundice hepatitis B and preparation method thereof
CN106038820A (en) Edible and medicinal traditional Chinese medicine composition for improving functional constipation and preparation method thereof
CN103656315B (en) Medicine being used for the treatment of porcine contagious pleuropneumonia and preparation method thereof
CN108771658A (en) A kind of bowel relaxing oral liquid and preparation method
CN114712219A (en) Acupoint pressure stimulation patch with effect of conditioning infantile pneumonia and cough
CN108714182A (en) Bowel relaxing oral liquid and preparation method
CN103040975B (en) Traditional Chinese medicine composition for nursing and treating infantile diarrhea
CN103330925B (en) A kind of medicine for the treatment of chorea minor and preparation method thereof
CN103007145B (en) Traditional Chinese medicine composition for treating children rotavirus enteritis and preparation method of composition
CN105327261A (en) Semen raphani traditional Chinese medicine combination capable of nourishing stomach and preparation method thereof
CN105343754A (en) Agilawood stomach nourishing traditional Chinese medicine composition and preparation method thereof
CN104888132A (en) Traditional Chinese medicine composition for treatment of chronic gastritis
CN109662229A (en) A kind of selenium-rich Poria cocos seed of jog&#39;s tears drinks of health care clearing damp and preparation method thereof
CN104587369B (en) A kind of pharmaceutical composition for treating visceral dysfunction halitosis disease and preparation method thereof
CN103690771B (en) Be used for the treatment of medicine of lamb colibacillosis and preparation method thereof
CN107362301A (en) Fragrant Siberian cocklebur appetizing particle
CN105412643A (en) Spray for treating pediatric water pathogen attacking heart type asthma and preparation method thereof
CN106620266A (en) Traditional Chinese medicine composition for treating mycoplasmal pneumonia of swine
CN106344680A (en) Traditional Chinese medicinal composition with effects of expelling wind and relieving cold-aggravated arthralgia and preparation method thereof
CN106310172A (en) Ointment medicine for treating painful diseases and preparing method and use thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20181109

RJ01 Rejection of invention patent application after publication