CN108714180A - Treat essential oil composition, preparation method and the preparation and application method of dysmenorrhoea - Google Patents
Treat essential oil composition, preparation method and the preparation and application method of dysmenorrhoea Download PDFInfo
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Abstract
The present invention provides a kind of essential oil composition for treating dysmenorrhoea, preparation method and preparation and application methods, are related to essential oil composition technical field, and the essential oil composition includes following component according to the mass fraction：1-3 parts of angelica essential oil, 0.6-1.5 parts of Rhizoma Chuanxiong essential oil, 0.3-0.7 parts of root bark of tree peony essential oil, 0.2-0.4 parts of rhizoma cyperi essential oil, 0.4-1 parts of 0.25-0.8 parts of P-Cymene and Lavender, it alleviates and takes anodyne treatment dysmenorrhoea for a long time, though symptom can be alleviated, but it cannot effect a radical cure, and the technical issues of will produce side reaction, essential oil composition provided by the invention not only has very strong fat-soluble and penetrating power, it is quickly absorbed by body, and it walks to alter with pungent perfume (or spice), fragrant qi-regulating and promoting blood circulation and stopping pain effect, it is notable to relieve pain regulating menoxenia, it can also pass through external medication simultaneously, it is simple and efficient, patient acceptance's higher, compliance is stronger.
Description
Technical field
The present invention relates to essential oil composition technical fields, more particularly, to a kind of essential oil composition for treating dysmenorrhoea, prepare
Method and preparation and application method.
Background technology
Dysmenorrhoea refers to front and back or painful menstrual periods of passing through, and in hypogastralgia, falling inflation, the soreness of waist, other symptoms include having a headache, being weary
Power, dizziness, nausea etc., pelvic cavity, genital tract are without organic disease.Dysmenorrhoea is that women is common, high morbidity, mostly occurs in puberty
Women shows that China dysmenorrhoea women accounts for 33.19%, and wherein dysmenorrhea accounts for 75% according to investigations.
With China's expanding economy, the realistic problems such as women work and life dual-pressure are big easily cause or aggravate pain
Through.Dysmenorrhoea is long-term, recurrent exerbation not only brings great body and mind pain to women, often because pain compared with acutely due to influence patient normal
Live and work.
Currently for the treatment of dysmenorrhoea, modern medicine is mainly sharp using prostaglandin synthase inhibitor, non-steroidal is taken orally
The analgesic drug products such as plain class drug, spasmolysis and analgesia class drug and calcium and magnesium preparation are treated, though however anodyne can alleviate symptom,
But it cannot effect a radical cure, and the long-term analgesic drug product that relies on will produce the side reactions such as nausea, the reduction of gastrointestinal mucosa ulcer, abdominal pain, granulocyte,
And curative effect cannot be lasting, is not suitable for being used for a long time.
In view of this, special propose the present invention.
Invention content
One of the objects of the present invention is to provide a kind of essential oil compositions for treating dysmenorrhoea, and analgesic is taken for a long time to alleviate
The technical issues of medicine treatment dysmenorrhoea cannot effect a radical cure, and will produce side reaction though can alleviate symptom, be not suitable for being used for a long time.
The essential oil composition for the treatment of dysmenorrhoea provided by the invention, including following component according to the mass fraction：Angelica essential oil
1-3 parts, 0.6-1.5 parts of Rhizoma Chuanxiong essential oil, 0.3-0.7 parts of root bark of tree peony essential oil, 0.2-0.4 parts of rhizoma cyperi essential oil, P-Cymene 0.25-0.8
0.4-1 parts of part and Lavender.
Further, the essential oil composition of the treatment dysmenorrhoea, including following component according to the mass fraction：Angelica essential oil
1.5-2.5 parts, 0.7-1.2 parts of Rhizoma Chuanxiong essential oil, 0.4-0.6 parts of root bark of tree peony essential oil, 0.25-0.4 parts of rhizoma cyperi essential oil, P-Cymene 0.2-
0.7 part and 0.45-0.8 parts of Lavender.
Further, the essential oil composition of the treatment dysmenorrhoea, including following component according to the mass fraction：Angelica essential oil
2-2.5 parts, 0.7-1 parts of Rhizoma Chuanxiong essential oil, 0.45-0.55 parts of root bark of tree peony essential oil, 0.25-0.35 parts of rhizoma cyperi essential oil, P-Cymene 0.2-
0.5 part and 0.45-0.7 parts of Lavender.
Further, the essential oil composition of the treatment dysmenorrhoea further includes 90-98 parts of base oil according to the mass fraction, excellent
92.5-97.5 parts are selected as, is still more preferably 93-97 parts；
Preferably, the base oil in Sweet Almond Oil, He Baba oil, grape seed oil or wheat-germ oil at least one
Kind, preferably SIMMONDSIA CHINENSIS SEED OIL.
The second object of the present invention is to provide the preparation method of the essential oil composition of above-mentioned treatment dysmenorrhoea, including walks as follows
Suddenly：Angelica essential oil, Rhizoma Chuanxiong essential oil, root bark of tree peony essential oil, rhizoma cyperi essential oil, P-Cymene, Lavender and optional base oil are mixed
Close uniformly to get to treatment dysmenorrhoea essential oil composition.
Further, the preparation method of the essential oil composition of the treatment dysmenorrhoea, includes the following steps：By angelica essential oil,
Rhizoma Chuanxiong essential oil, root bark of tree peony essential oil, rhizoma cyperi essential oil, P-Cymene and Lavender sequentially add in base oil, are uniformly mixed, that is, make
The essential oil composition of dysmenorrhoea must be treated.
The third object of the present invention is to provide a kind of essential oil formulation for treating dysmenorrhoea, including treatment provided by the invention pain
The essential oil composition of warp.
Further, the essential oil formulation of the treatment dysmenorrhoea, further includes pharmaceutically acceptable auxiliary material；
Preferably, the auxiliary material includes excipient, binder, filler, lubricant, antioxidant, preservative or thickening
At least one of agent.
Further, the dosage form of the essential oil formulation of the treatment dysmenorrhoea is external preparation；
Preferably, the dosage form of the preparation is essential oil agent, patch, cream, micro emulsion gels or suspension.
The fourth object of the present invention is to provide the application method of the essential oil composition of above-mentioned treatment dysmenorrhoea, including walks as follows
Suddenly：In menalgia or 3-7 days before menstrual period, essential oil is applied to the Guanyuan point of navel and the lower three cun of underbellies of navel.
The fifth purpose of the present invention is to provide the application method of the essential oil formulation of above-mentioned treatment dysmenorrhoea, including walks as follows
Suddenly：In menalgia or 3-7 days before menstrual period, essential oil is applied to the Guanyuan point of navel and the lower three cun of underbellies of navel.
For the essential oil composition for the treatment of dysmenorrhoea provided by the invention using theory of traditional Chinese medical science as principle, formula is reasonable, it then follows " palpus person,
Watching class can not be from " principle choose different essential oils, pass through angelica essential oil, Rhizoma Chuanxiong essential oil, root bark of tree peony essential oil, rhizoma cyperi essential oil, Chinese mugwort
Leaf essential oil and Lavender coordinated not only have very strong fat-soluble and penetrating power, are quickly absorbed by body, and
Walk to alter with pungent perfume (or spice), fragrant qi-regulating and promoting blood circulation and stopping pain effect, analgesic regulating menoxenia it is notable, while can also by external medication,
Safe and efficient, simple and efficient, patient acceptance's higher, compliance is stronger.
The preparation method of the essential oil composition for the treatment of dysmenorrhoea provided by the invention is simple for process, easy to operate, can be applicable in
In industrialized production, production efficiency is improved.
The essential oil formulation for the treatment of dysmenorrhoea provided by the invention, the essential oil composition with treatment dysmenorrhoea provided by the invention is to have
Ingredient is imitated, by angelica essential oil, Rhizoma Chuanxiong essential oil, root bark of tree peony essential oil, rhizoma cyperi essential oil, P-Cymene and Lavender coordinated,
Not only there is very strong fat-soluble and penetrating power, quickly absorbed by body, and walk to alter with pungent perfume (or spice), fragrant qi-regulating and promoting blood circulation
Analgesic efficacy, analgesic regulating menoxenia is notable, while can also be by external medication, and simple and efficient, patient acceptance's higher is complied with
Property is stronger.
Specific implementation mode
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the invention.It is not specified in embodiment specific
Condition person carries out according to conventional conditions or manufacturer's recommended conditions.Reagents or instruments used without specified manufacturer is
The conventional products that can be obtained by commercially available purchase.
According to an aspect of the present invention, the essential oil composition of dysmenorrhoea is treated the present invention provides a kind of, including presses quality
The following component of number meter：1-3 parts of angelica essential oil, 0.6-1.5 parts of Rhizoma Chuanxiong essential oil, 0.3-0.7 parts of root bark of tree peony essential oil, rhizoma cyperi essential oil
0.2-0.4 parts, 0.4-1 parts of 0.25-0.8 parts of P-Cymene and Lavender.
In the present invention, angelica essential oil, Rhizoma Chuanxiong essential oil, root bark of tree peony essential oil, rhizoma cyperi essential oil, P-Cymene and Lavender are equal
It is obtained respectively by extraction by steam distillation from Radix Angelicae Sinensis, Rhizoma Chuanxiong, the root bark of tree peony, rhizoma cyperi, folium artemisiae argyi and lavender.
In the present invention, various essential oils can also extract to obtain by supercritical extraction.
In the present invention, the typical but non-limiting mass fraction of angelica essential oil as 1,1.1,1.2,1.3,1.4,
1.5,1.6,1.71.8,1.9,2,2.1,2.2,2.3,2.4,2.5,2.6,2.7,2.8,2.9 or 3 part.
Angelica essential oil replenishing and activating blood, menstruction regulating and pain relieving, relax bowel, for blood deficiency chlorosis, dizziness palpitaition, irregular menstruation, warp
Close dysmenorrhoea, asthenia cold abdominalgia, dry constipation of intestines, arthralgia pain due to rheumatism, ulcer sores.
In the present invention, the typical but non-limiting mass fraction of Rhizoma Chuanxiong essential oil as 0.6,0.65,0.7,0.75,
0.8,0.85,0.9,0.95,1,1.05,1.1,1.15,1.2,1.25,1.3,1.35,1.4,1.45 or 1.5 part.
Rhizoma Chuanxiong essential oil blood-activating and qi-promoting, wind-expelling pain-stopping.For irregular menstruation, closed dysmenorrhea, abdominal mass abdominal pain, chest side of body shouting pain.
In the present invention, the typical but non-limiting mass fraction of root bark of tree peony essential oil as 0.3,0.35,0.38,0.4,
0.42,0.45,0.48,0.5,0.52,0.55,0.58,0.6,0.62,0.65,0.68 or 0.7 part.
Root bark of tree peony essential oil clearing heat and cooling blood, it is promoting blood circulation and removing blood stasis.For febrile virulent maculae, hematemesis and epistaxis, night fever abating at dawn, lossless hectic fever due to yin, warp
Close dysmenorrhoea, carbuncle sore tumefacting virus, the pain of injury caused by falling and tumbling.
In the present invention, the typical but non-limiting mass fraction of rhizoma cyperi essential oil as 0.2,0.21,0.22,0.23,
0.24、0.25、0.26、0.27、0.28、0.29、0.3、0.31、0.32、0.33、0.34、0.35、0.36、0.37、0.38、
0.39 or 0.4 part.
Rhizoma cyperi essential oil promoting qi circulation and removing obstruction in the collateral, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, chest, the side of body, abdominal distention, indigestion, chest gastral cavity ruffian
It is bored, cold hernia stomachache, swollen breasts, irregular menstruation, closed dysmenorrhea.
In the present invention, the typical but non-limiting mass fraction of P-Cymene as 0.25,0.3,0.35,0.4,
0.45,0.5,0.55,0.6,0.65,0.7,0.75 or 0.8 part.
P-Cymene eliminating cold to stop pain, warming channel for arresting bleeding.
In the present invention, the typical but non-limiting mass fraction of Lavender as 0.45,0.48,0.5,
0.52,0.55,0.58,0.6,0.62,0.65,0.68,0.7,0.72,0.75,0.78 or 0.8 part.
Lavender is releived intense strain, the calm mind, calms down pneumostatic, also has spasmolysis to ileum and uterine smooth muscle
Effect.
In the present invention, the reason of selecting essential oil to prepare treatment dysmenorrhoea drug as bulk pharmaceutical chemicals includes the following aspects：
(1) essential oil, which is derived from, is naturally attributed to health：Plants essential oil is the secondary metabolites in plant, opposite by molecular weight
Smaller simple compounds composition, has certain aromatic odor, the oily liquids substance that can be volatilized at normal temperatures, have flavouring,
Sterilization, antiviral and anti-oxidant etc. bioactivity.There is the essential oil of " liquid golden " good reputation by green, natural, safely, effectively
Etc. advantages received by more and more people；
(2) using instruction of Chinese Medicine theory as principle, formula is reasonable：Pass through angelica essential oil, Rhizoma Chuanxiong essential oil, root bark of tree peony essential oil, rhizoma cyperi
Essential oil, P-Cymene and Lavender mutually cooperate with medication, effect multiplication to be more suitable for needed for illness, therapeutic effect is more preferably；
(3) safe and efficient：Essential oil is originated from draft, is the essence of effective ingredients in plant concentration, more efficiently, and essential oil is transdermal
Property it is good, work faster, effect is more preferable.
In the preferred embodiment of the present invention, the essential oil composition for treating dysmenorrhoea further includes according to the mass fraction
90-98 parts of base oil.
By the way that base oil is added in the essential oil composition for the treatment of dysmenorrhoea, so that the skin-friendly of essential oil composition is more preferable,
It more being capable of rapid osmotic skin.
In the preferred embodiment of the present invention, in the essential oil composition for treating dysmenorrhoea, the typical but non-limit of base oil
The mass fraction of property processed as 90,90.5,91,91.5,92,92.5,93,93.5,94,94.5,95,95.5,96,96.5,97,
97.5 or 98 parts.
In present invention further optimization embodiment, base oil be selected from Sweet Almond Oil, He Baba oil, grape seed oil or
At least one of wheat-germ oil, preferably SIMMONDSIA CHINENSIS SEED OIL.
Due to SIMMONDSIA CHINENSIS SEED OIL neutrality non-greasy, there is good skin-friendly, can moisten and soften skin quality, therefore, selects
Oil is better based on SIMMONDSIA CHINENSIS SEED OIL.
According to the second aspect of the invention, the present invention provides a kind of preparation sides of essential oil composition that treating dysmenorrhoea
Method includes the following steps：By angelica essential oil, Rhizoma Chuanxiong essential oil, root bark of tree peony essential oil, rhizoma cyperi essential oil, P-Cymene, Lavender and appoint
The base oil of choosing is uniformly mixed to get to the essential oil composition for the treatment of dysmenorrhoea.
The preparation method of the essential oil composition for the treatment of dysmenorrhoea provided by the invention is simple for process, easy to operate, can be applicable in
In industrialized production, production efficiency is improved.
In the preferred embodiment of the present invention, prepare treatment dysmenorrhoea essential oil composition when, by angelica essential oil,
Rhizoma Chuanxiong essential oil, root bark of tree peony essential oil, rhizoma cyperi essential oil, P-Cymene and Lavender sequentially add in base oil, are uniformly mixed, that is, make
The essential oil composition of dysmenorrhoea must be treated.
In present invention further optimization embodiment, base oil is placed in suitable container, sequentially adds Radix Angelicae Sinensis
Essential oil, Rhizoma Chuanxiong essential oil, root bark of tree peony essential oil, rhizoma cyperi essential oil, P-Cymene and Lavender after fully shaking up, obtain treatment pain
The essential oil composition of warp, it is spare after closed preservation.
According to the third aspect of the present invention, the present invention provides a kind of essential oil formulations for treating dysmenorrhoea, including the present invention
The essential oil composition of the treatment dysmenorrhoea of offer.
The essential oil formulation for the treatment of dysmenorrhoea provided by the invention, the essential oil composition with treatment dysmenorrhoea provided by the invention is to have
Ingredient is imitated, by angelica essential oil, Rhizoma Chuanxiong essential oil, root bark of tree peony essential oil, rhizoma cyperi essential oil, P-Cymene and Lavender coordinated,
Not only there is very strong fat-soluble and penetrating power, quickly absorbed by body, and walk to alter with pungent perfume (or spice), fragrant qi-regulating and promoting blood circulation
Analgesic efficacy, analgesic regulating menoxenia is notable, while can also be by external medication, and simple and efficient, patient acceptance's higher is complied with
Property is stronger.
In the preferred embodiment of the present invention, the essential oil formulation for treating dysmenorrhoea further includes pharmaceutically acceptable auxiliary
Material.
By the way that pharmaceutically acceptable auxiliary material is added in the essential oil formulation for the treatment of dysmenorrhoea, so that preparation can be made not
Same dosage form, meets the use needs of patient.
In present invention further optimization embodiment, auxiliary material includes excipient, binder, filler, lubricant, resists
At least one of oxidant or thickener.
In the preferred embodiment of the present invention, treat the essential oil agent of dysmenorrhoea dosage form be external preparation, pass through by
The essential oil formulation for the treatment of dysmenorrhoea is set as external preparation, safer convenient, avoid Long-term taking medicine and caused by drug resistance and liver
The side effects such as toxicity.
In the preferred embodiment of the present invention, the essential oil formulation for treating dysmenorrhoea is patch, cream, micro emulsion gel
Agent, suspension or microcapsule formulations.
According to the fourth aspect of the present invention, the present invention provides the application method of above-mentioned treatment dysmenorrhoea essential oil composition,
Include the following steps：In menalgia or 3-7 days before menstrual period, essential oil is applied to the Guanyuan point of navel and the lower three cun of underbellies of navel
?.
According to the fifth aspect of the present invention, the present invention provides the application method of the essential oil formulation of above-mentioned treatment dysmenorrhoea,
Include the following steps：In menalgia or 3-7 days before menstrual period, essential oil is applied to the Guanyuan point of navel and the lower three cun of underbellies of navel
?.
The essential oil composition and essential oil formulation for the treatment of dysmenorrhoea provided by the invention by smearing administration in vitro, it is safer just
Victory, the side effects such as drug resistance and hepatotoxicity wind agitation caused by avoiding long-term endo-medicine.
Technical solution provided by the invention is further described with reference to embodiment and comparative example.
Embodiment 1
Present embodiments provide a kind of essential oil composition for treating dysmenorrhoea, including following component according to the mass fraction：When
Return 1 part of essential oil, 1.5 parts of Rhizoma Chuanxiong essential oil, 0.6 part of root bark of tree peony essential oil, 0.4 part of rhizoma cyperi essential oil, 0.7 part of P-Cymene, Lavender
0.8 part and 95 parts of SIMMONDSIA CHINENSIS SEED OIL, the sum of above-mentioned each component are 100 parts.
Embodiment 2
Present embodiments provide a kind of essential oil composition for treating dysmenorrhoea, including following component according to the mass fraction：When
Return 3 parts of essential oil, 0.6 part of Rhizoma Chuanxiong essential oil, 0.4 part of root bark of tree peony essential oil, 0.25 part of rhizoma cyperi essential oil, 0.3 part of P-Cymene, Lavender
0.45 part and 95 parts of SIMMONDSIA CHINENSIS SEED OIL, the sum of above-mentioned each component are 100 parts.
Embodiment 3
Present embodiments provide a kind of essential oil composition for treating dysmenorrhoea, including following component according to the mass fraction：When
Return 1.5 parts of essential oil, 1.2 parts of Rhizoma Chuanxiong essential oil, 0.4 part of root bark of tree peony essential oil, 0.4 part of rhizoma cyperi essential oil, 0.2 part of P-Cymene, lavender essence
95.5 parts of 0.8 part of oil and SIMMONDSIA CHINENSIS SEED OIL, the sum of above-mentioned each component are 100 parts.
Embodiment 4
Present embodiments provide a kind of essential oil composition for treating dysmenorrhoea, including following component according to the mass fraction：When
Return 2 parts of essential oil, 1 part of Rhizoma Chuanxiong essential oil, 0.45 part of root bark of tree peony essential oil, 0.35 part of rhizoma cyperi essential oil, 0.3 part of P-Cymene, Lavender
0.5 part and 95.5 parts of SIMMONDSIA CHINENSIS SEED OIL, the sum of above-mentioned each component are 100 parts.
Embodiment 5
Present embodiments provide a kind of essential oil composition for treating dysmenorrhoea, including following component according to the mass fraction：When
Return 2.5 parts of essential oil, 0.7 part of Rhizoma Chuanxiong essential oil, 0.5 part of root bark of tree peony essential oil, 0.3 part of rhizoma cyperi essential oil, 0.4 part of P-Cymene, lavender essence
95 parts of 0.6 part of oil and SIMMONDSIA CHINENSIS SEED OIL, the sum of above-mentioned each component are 100 parts.
Embodiment 6
A kind of preparation method of essential oil composition that treating dysmenorrhoea is present embodiments provided, is included the following steps：It will be basic
Oil is placed in suitable container, is sequentially added angelica essential oil, Rhizoma Chuanxiong essential oil, root bark of tree peony essential oil, rhizoma cyperi essential oil, P-Cymene and is smoked clothing
Careless essential oil, fully shakes up, closed preservation, obtains the essential oil composition for the treatment of dysmenorrhoea.
Comparative example 1
This comparative example provides a kind of ibuprofen granule.
Comparative example 2
This comparative example provides a kind of essential oil composition for treating dysmenorrhoea, and the difference of this comparative example and embodiment 5 exists
In 5 parts of angelica essential oil, 95 parts of SIMMONDSIA CHINENSIS SEED OIL is not added with other essential oils.
Comparative example 3
This comparative example provides a kind of essential oil composition for treating dysmenorrhoea, and the difference of this comparative example and embodiment 5 exists
In 5 parts of Rhizoma Chuanxiong essential oil, 95 parts of SIMMONDSIA CHINENSIS SEED OIL is not added with other essential oils.
Comparative example 4
This comparative example provides a kind of essential oil composition for treating dysmenorrhoea, and the difference of this comparative example and embodiment 5 exists
In 5 parts of root bark of tree peony essential oil, 95 parts of SIMMONDSIA CHINENSIS SEED OIL is not added with other essential oils.
Comparative example 5
This comparative example provides a kind of essential oil composition for treating dysmenorrhoea, and the difference of this comparative example and embodiment 5 exists
In 5 parts of rhizoma cyperi essential oil, 95 parts of SIMMONDSIA CHINENSIS SEED OIL is not added with other essential oils.
Comparative example 6
This comparative example provides a kind of essential oil composition for treating dysmenorrhoea, and the difference of this comparative example and embodiment 5 exists
In 5 parts of P-Cymene, 95 parts of SIMMONDSIA CHINENSIS SEED OIL is not added with other essential oils.
Comparative example 7
This comparative example provides a kind of essential oil composition for treating dysmenorrhoea, and the difference of this comparative example and embodiment 5 exists
In 5 parts of Lavender, 95 parts of SIMMONDSIA CHINENSIS SEED OIL is not added with other essential oils.
Comparative example 8
This comparative example provides a kind of essential oil composition for treating dysmenorrhoea, including following component according to the mass fraction, when
Return 4 parts of essential oil, 0.3 part of Rhizoma Chuanxiong essential oil, 0.2 part of root bark of tree peony essential oil, 0.2 part of rhizoma cyperi essential oil, 0.1 part of P-Cymene, Lavender
0.2 part and 95 parts of SIMMONDSIA CHINENSIS SEED OIL.
Difference lies in the content of each essential oil component is different with embodiment 5 for this comparative example.
Comparative example 9
This comparative example provides a kind of essential oil composition for treating dysmenorrhoea, including following component according to the mass fraction, when
Return 0.5 part of essential oil, 2 parts of Rhizoma Chuanxiong essential oil, 0.8 part of root bark of tree peony essential oil, 0.5 part of rhizoma cyperi essential oil, 0.1 part of P-Cymene, Lavender
1.1 parts and 95 parts of SIMMONDSIA CHINENSIS SEED OIL.
Difference lies in the content of each essential oil component is different with embodiment 5 for this comparative example.
Comparative example 10
This comparative example provides a kind of essential oil composition for treating dysmenorrhoea, including following component according to the mass fraction：When
Return 3 parts of essential oil, 0.6 part of root bark of tree peony essential oil, 0.4 part of rhizoma cyperi essential oil, 0.4 part of P-Cymene, 0.6 part of Lavender and SIMMONDSIA CHINENSIS SEED OIL
95 parts, the sum of above-mentioned each component is 100 parts.
Difference lies in a little higher than realities of content of angelica essential oil, root bark of tree peony essential oil and rhizoma cyperi essential oil with embodiment 5 for this comparative example
Example 5 is applied, but Rhizoma Chuanxiong essential oil is not added.
Comparative example 11
This comparative example provides a kind of essential oil composition for treating dysmenorrhoea, including following component according to the mass fraction：When
Return 2.5 parts of essential oil, 0.7 part of Rhizoma Chuanxiong essential oil, 0.4 part of rhizoma cyperi essential oil, 0.6 part of P-Cymene, 0.8 part of Lavender and Jojoba
95 parts of oil, the sum of above-mentioned each component are 100 parts.
Difference lies in the content of rhizoma cyperi essential oil, P-Cymene and Lavender is a little higher than with embodiment 5 for this comparative example
Embodiment 5, but root bark of tree peony essential oil is not added.
Comparative example 12
This comparative example provides a kind of essential oil composition for treating dysmenorrhoea, including following component according to the mass fraction：When
Return 2.5 parts of essential oil, 0.8 part of Rhizoma Chuanxiong essential oil, 0.6 part of root bark of tree peony essential oil, 0.5 part of P-Cymene, 0.6 part of Lavender and Jojoba
95 parts of oil, the sum of above-mentioned each component are 100 parts.
Difference lies in a little higher than realities of content of Rhizoma Chuanxiong essential oil, root bark of tree peony essential oil and P-Cymene with embodiment 5 for this comparative example
Example 5 is applied, but rhizoma cyperi essential oil is not added.
Comparative example 13
This comparative example provides a kind of essential oil composition for treating dysmenorrhoea, including following component according to the mass fraction：When
Return 2.5 parts of essential oil, 0.8 part of Rhizoma Chuanxiong essential oil, 0.6 part of root bark of tree peony essential oil, 0.4 part of rhizoma cyperi essential oil, 0.8 part of Lavender and Jojoba
95 parts of oil, the sum of above-mentioned each component are 100 parts.
Difference lies in, Rhizoma Chuanxiong essential oil, root bark of tree peony essential oil, rhizoma cyperi essential oil and Lavenders for this comparative example and embodiment 5
The a little higher than embodiment 5 of content, but P-Cymene is not added.
Comparative example 14
This comparative example provides a kind of essential oil composition for treating dysmenorrhoea, including following component according to the mass fraction：When
Return 2.5 parts of essential oil, 0.8 part of Rhizoma Chuanxiong essential oil, 0.6 part of root bark of tree peony essential oil, 0.4 part of rhizoma cyperi essential oil, 0.8 part of P-Cymene and Jojoba
95 parts of oil, the sum of above-mentioned each component are 100 parts.
Difference lies in, Rhizoma Chuanxiong essential oil, root bark of tree peony essential oil, rhizoma cyperi essential oil and P-Cymene to contain for this comparative example and embodiment 5
A little higher than embodiment 5 is measured, but Lavender is not added.
Comparative example 15
This comparative example provides a kind of essential oil composition for treating dysmenorrhoea, including following component according to the mass fraction：When
95 parts of 3 parts of essential oil, 1 part of Rhizoma Chuanxiong essential oil, 0.6 part of root bark of tree peony essential oil, 0.4 part of rhizoma cyperi essential oil and SIMMONDSIA CHINENSIS SEED OIL, above-mentioned each group is returned to divide it
Be 100 parts.
Difference lies in, a little higher than embodiments 5 of content for this comparative example and embodiment 5, but Lavender and Chinese mugwort are not added
Leaf essential oil.
Comparative example 16
This comparative example provides a kind of essential oil composition for treating dysmenorrhoea, including following component according to the mass fraction：When
Return 1 part of 3 parts of essential oil, 0.4 part of rhizoma cyperi essential oil, 0.6 part of P-Cymene and Lavender and 95 parts of SIMMONDSIA CHINENSIS SEED OIL, above-mentioned each component
The sum of be 100 parts.
Difference lies in angelica essential oil, rhizoma cyperi essential oil and P-Cymene and Lavender contain this comparative example with embodiment 5
A little higher than embodiment 5 is measured, but Rhizoma Chuanxiong essential oil and root bark of tree peony essential oil are not added.
Embodiment 7-11
Embodiment 7-11 each provides a kind of essential oil patch for treating dysmenorrhoea, the essence provided respectively by embodiment 1-5
Fluid composition is prepared.
Comparative example 17-32
Comparative example 17-32 each provides a kind of essential oil patch for treating dysmenorrhoea, is provided respectively by comparative example 1-16
The medicine preparation for the treatment of dysmenorrhoea forms.
Test example 1
Mice clinical experiment is carried out to each embodiment and comparative example, to measure therapeutic effect of the different groups for dysmenorrhoea.
1.1 material
1.1.1 animal
Healthy adult female Wistar rats, cleaning grade, weight 180-200g.
1.1.2 reagent and material
Ibuprofen granule；Rat blood serum IFN- kits；IL-4ELISA kits；P of Rats GF2 enzyme linked immunosorbent detections are tried
Agent box；L-arginine methyl esters (L-NAME) and Rockwell liquid (Locke's solu-tion)；
1.1.3 instrument
MacLab/4e channel polygraphs；
1.2 mouse analgesic tests
1.2.1 pain model in mice is established using 55 DEG C of thermostimulations
Female mice is placed on the constant temperature hot-plate instrument for being preheating to 55 DEG C, to lick metapedes as pain reaction, is to lick metapedes
Pain reaction, to there is licking incubation period of metapedes as the mean of pain threshold 2 threshold of pains using before medicine as the basic threshold of pain.
1.2.2 influence of the essential oil composition to mouse pain threshold is measured
The mouse for choosing the preceding Basic Pain Threshold value of administration qualified (threshold of pain is more than 5s, is less than 30s), is randomly divided into 22 groups, every group
10, give embodiment 7-11 and comparative example the 17-32 patch provided to 1-21 groups, wherein 1-5 groups give embodiment 7-11 groups
The essential oil composition of offer, (3.2g/kg) 6-21 groups give the treatment dysmenorrhoea drug (0.06g/ of comparative example 17-32 groups offer
Kg), the 22nd group is blank control group, gives same dosage distilled water, records 22 groups of mouse reactions respectively, sees that the results are shown in Table 1：
The pain threshold of 22 groups of mouse after table 1 is administered
1-5 groups and 22 groups of comparison can be seen that the essential oil composition for the treatment dysmenorrhoea that embodiment 1-5 is provided from table 1
The threshold value of mouse can be significantly improved, this illustrates that there is the essential oil composition for the treatment of dysmenorrhoea provided by the invention apparent analgesic to imitate
Fruit.
The 6th group and the 22nd group of comparison can be seen that the brufen group threshold of pain and anticipate without statistics with blank control group from table 1
Justice.
5 groups of essential oil compositions that can be seen that the treatment dysmenorrhoea that embodiment 5 provides with the comparison of 7-21 groups from table 1
It is assisted by the angelica essential oil of extra fine quality number, Rhizoma Chuanxiong essential oil, root bark of tree peony essential oil, rhizoma cyperi essential oil, P-Cymene and Lavender
With cooperation, more preferably to the analgesic effect of mouse.
1.3 rat analgesic experiments
1.3.1 rat dysmenorrhea model is established using oxytocin method
Using dysmenorrhea model Isolated Rat Uterus smooth muscle contraction amplitude, frequency as index, embodiment 1-5 and comparative example are evaluated
Influence of the drug that 1-16 is provided to the smooth musculation of rat uterus
1.3.2 experimental method
The female sd inbred rats that oxytocin is induced to dysmenorrhea model are randomly divided into 22 groups, every group 10, respectively 1-22 groups,
In the 22nd group be blank control group, in addition to the 22nd group, other rats are subcutaneously injected diethylstilbestrol 2mg/kg daily, continuous 10
It.Since diethylstilbestrol being subcutaneously injected the 6th, 1-5 groups give the embodiment 7-11 essential oil composition patches provided, 6- respectively
21 groups are given the comparative example 17-32 medicine patch provided respectively.22 groups of injection same volume distilled water, continuous 5 days.After the last administration
1h, intraperitoneal injection oxytocin 20U/kg.There is the incubation period of pain reaction (writhing response) in immediate record rat, writhing in 30min
Number calculates the inhibiting rate of writhing number.Writhing number inhibiting rate=(model group writhing number-administration group writhing number)/mould
Type group writhing number × 100%.PGF2 in rat blood serumαThe above-mentioned rat of assay injects 30min after oxytocin, ether fiber crops
Liquor-saturated, abdominal vein takes blood, after processing, measures PGF2 in each group rat blood serumαContent.After above-mentioned animal pattern takes blood simultaneously,
It is rapid to take out rat uterus, it is placed in cold Rockwell liquid and cleans, take every side cornua uteri stage casing 2cm, be fixed on and fill 10mL Rockwell liquid
Thermostatic bath in, on the tonotransducer that is connected with MecLab/4e.Solution temperature is 37.5-38 DEG C in bath, and constant is logical
Enter 95%O2+ 5%CO2Mixed gas.It adjusts micro actuator and adds preload 1g, balance 40min, wait for that spontaneous rhythm is restored in uterus, shrink
After frequency and amplitude stabilization, the contraction frequency and amplitude of each group animal uterus are recorded.
Influence of 2 drug of table to rat model
Note:Compared with blank control group:* P < 0.05；* P < 0.01
From table 2 1-5 groups and the 22nd group of blank can be seen that essential oil composition that embodiment 1-5 is provided can be notable
In the incubation period for extending rat pain, the writhing number of rat is reduced, it is notable that this illustrates that the essential oil composition that embodiment 1-5 is provided has
Analgesic activity.
From 1-5 groups and 6 groups of the analgesic effect for comparing the essential oil composition that can be seen that embodiment 1-5 offers and cloth Lip river
Fragrant particle is suitable.
The essential oil composition that can be seen that the treatment dysmenorrhoea that embodiment 1-5 is provided from the comparison of 1-5 groups and 7-21 groups passes through
Angelica essential oil, Rhizoma Chuanxiong essential oil, root bark of tree peony essential oil, rhizoma cyperi essential oil, P-Cymene and the Lavender collaboration of extra fine quality number are matched
It closes, more preferably to the analgesic effect of rat.
3 drug of table is to PEG2 in Isolated Rat Uterus contraction frequency and amplitude and serumαInfluence
From table 3 it is observed that the uterine myometrium frequency of 1-5 group rats is substantially less than 22 groups, PGF2αIt is significantly low
In 22 groups, this illustrates that the essential oil composition that embodiment 1-5 is provided can significantly reduce oxytocin to rat uterus smooth muscle contraction
Influence, inhibit rat body in PEG2αSynthesis or release, reduce pain.
By 1-5 groups with 6 groups of comparison as can be seen that the essential oil composition that embodiment 1-5 is provided to smooth muscle contraction
Inhibition it is suitable with ibuprofen granule.
The essential oil composition that can be seen that the treatment dysmenorrhoea that embodiment 1-5 is provided from the comparison of 1-5 groups and 7-21 groups passes through
Angelica essential oil, Rhizoma Chuanxiong essential oil, root bark of tree peony essential oil, rhizoma cyperi essential oil, P-Cymene and the Lavender collaboration of extra fine quality number are matched
It closes, more can significantly reduce influence of the oxytocin to rat uterus smooth muscle contraction, inhibit PEG2 in rat bodyαSynthesis or release
It puts, reduces pain.
Test example 2
Choose the female patient 76 with dysmenorrhoea history, age 17-38 Sui, experimental group 40, control group 36, experimental group
With control group patient on age, the course of disease and pain degree no significant difference (P>0.05) it, is comparable, wherein testing component
The essential oil composition of the offer of embodiment 5 is not given, and control group gives equivalent distilled water, and measures record observation reaction and refer to
Mark, as a result as shown in Table 4-6.
4 pretherapy and post-treatment menses prostaglandin (PGF2 of tableα) horizontal comparison (x ± s, pg/mL)
| Number of cases (people) | Before treatment | After treatment | |
| Experimental group (embodiment 5) | 40 | 448.80±53.76 | 372.01±64.53 |
| Control group (distilled water) | 36 | 462.6±55.29 | 431.81±35.03 |
The comparison of experimental group and control group can be seen that experimental group from table 4 can significantly reduce PGF2 after the treatmentα,
This illustrates that the essential oil composition that experimental group provides has therapeutic effect to human body dysmenorrhoea.
5 pretherapy and post-treatment erythrocyte sedimentation rate numerical value of table compares
| Number of cases (people) | Before treatment | After treatment | |
| Experimental group (embodiment 5) | 40 | 24.38±5.45 | 12.23±6.17 |
| Control group (distilled water) | 36 | 23.74±5.18 | 19.32±6.83 |
As can be seen from Table 5, the essential oil composition that embodiment 5 provides can increase blood perfusion amount, improve microcirculation,
Coordinate uterine function activity, dysmenorrhoea is made to alleviate.
6 patient clinical efficacy data table (example %) of table
As can be seen from Table 6, the essential oil composition that embodiment 5 provides total effective rate in using crowd reaches 90%, this
Illustrate that the essential oil composition can adjust prostate levels in blood, to alleviate smooth muscle tone state, and can dredge through adjusting blood to make
Uterus microcirculating state is effectively improved.
Finally it should be noted that：The above embodiments are only used to illustrate the technical solution of the present invention., rather than its limitations；To the greatest extent
Present invention has been described in detail with reference to the aforementioned embodiments for pipe, it will be understood by those of ordinary skill in the art that：Its according to
So can with technical scheme described in the above embodiments is modified, either to which part or all technical features into
Row equivalent replacement；And these modifications or replacements, various embodiments of the present invention technology that it does not separate the essence of the corresponding technical solution
The range of scheme.
Claims (10)
1. it is according to claim 1 treatment dysmenorrhoea essential oil composition, which is characterized in that including according to the mass fraction as
Lower component：1-3 parts of angelica essential oil, 0.6-1.5 parts of Rhizoma Chuanxiong essential oil, 0.3-0.7 parts of root bark of tree peony essential oil, 0.2-0.4 parts of rhizoma cyperi essential oil, Chinese mugwort
0.4-1 parts of 0.25-0.8 parts of leaf essential oil and Lavender.
2. it is according to claim 1 treatment dysmenorrhoea essential oil composition, which is characterized in that including according to the mass fraction as
Lower component：1.5-2.5 parts of angelica essential oil, 0.7-1.2 parts of Rhizoma Chuanxiong essential oil, 0.4-0.6 parts of root bark of tree peony essential oil, rhizoma cyperi essential oil 0.25-0.4
Part, 0.45-0.8 parts of 0.2-0.7 parts of P-Cymene and Lavender.
3. it is according to claim 1 treatment dysmenorrhoea essential oil composition, which is characterized in that including according to the mass fraction as
Lower component：2-2.5 parts of angelica essential oil, 0.7-1 parts of Rhizoma Chuanxiong essential oil, 0.45-0.55 parts of root bark of tree peony essential oil, rhizoma cyperi essential oil 0.25-0.35
Part, 0.45-0.7 parts of 0.2-0.5 parts of P-Cymene and Lavender.
4. treating the essential oil composition of dysmenorrhoea according to claim 1-3 any one of them, which is characterized in that further include by quality
90-98 parts of the base oil of number meter, preferably 92.5-97.5 parts, be still more preferably 93-97 parts；
Preferably, the base oil is selected from least one of Sweet Almond Oil, He Baba oil, grape seed oil or wheat-germ oil,
Preferably SIMMONDSIA CHINENSIS SEED OIL.
5. treating the preparation method of the essential oil composition of dysmenorrhoea according to claim 1-3 any one of them, which is characterized in that packet
Include following steps：By angelica essential oil, Rhizoma Chuanxiong essential oil, root bark of tree peony essential oil, rhizoma cyperi essential oil, P-Cymene, Lavender and optional
Base oil be uniformly mixed to get to treatment dysmenorrhoea essential oil composition.
6. the preparation method of the essential oil composition for the treatment of dysmenorrhoea according to claim 5, which is characterized in that including walking as follows
Suddenly：
Angelica essential oil, Rhizoma Chuanxiong essential oil, root bark of tree peony essential oil, rhizoma cyperi essential oil, P-Cymene and Lavender are sequentially added into base oil
In, it is uniformly mixed, obtains the essential oil composition for the treatment of dysmenorrhoea.
7. a kind of essential oil formulation for treating dysmenorrhoea, which is characterized in that treat dysmenorrhoea including claim 1-4 any one of them
Essential oil composition.
8. the essential oil formulation for the treatment of dysmenorrhoea according to claim 7, which is characterized in that further include pharmaceutically acceptable auxiliary
Material；
Preferably, the auxiliary material includes in excipient, binder, filler, lubricant, antioxidant, preservative or thickener
At least one.
9. the essential oil formulation for the treatment of dysmenorrhoea according to claim 7, which is characterized in that the dosage form of the preparation is external application system
Agent；
Preferably, the dosage form of the preparation is essential oil agent, patch, cream, micro emulsion gels or suspension.
10. being treated described in essential oil composition or the claim any one of 7-9 of dysmenorrhoea according to claim 1-4 any one of them
Treatment dysmenorrhoea essential oil formulation application method, which is characterized in that include the following steps：3- in menalgia or before menstrual period
7 days, essential oil is applied to the Guanyuan point of navel and the lower three cun of underbellies of navel.
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